CA2208233A1 - Utilisation de molecules se fixant a cnh-ii et/ou simulant cnh-ii dans la prevention et/ou le traitement des etats inflammatoires - Google Patents

Utilisation de molecules se fixant a cnh-ii et/ou simulant cnh-ii dans la prevention et/ou le traitement des etats inflammatoires

Info

Publication number
CA2208233A1
CA2208233A1 CA002208233A CA2208233A CA2208233A1 CA 2208233 A1 CA2208233 A1 CA 2208233A1 CA 002208233 A CA002208233 A CA 002208233A CA 2208233 A CA2208233 A CA 2208233A CA 2208233 A1 CA2208233 A1 CA 2208233A1
Authority
CA
Canada
Prior art keywords
mhc
molecules
lps
cell
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002208233A
Other languages
English (en)
Inventor
Roger Pascal Lauener
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires OM SA
DEUTSCHE OM ARZNEIMITTEL GmbH
Original Assignee
Laboratories Om SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratories Om SA filed Critical Laboratories Om SA
Publication of CA2208233A1 publication Critical patent/CA2208233A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)

Abstract

La présente invention se rapporte à des molécules se fixant à CMH-II (complexe majeur d'histocompatibilité) et/ou simulant CMH-II, ces molécules servant à intervenir dans l'interaction entre un stimulus d'activation des cellules porteuses de CMH-II telles que les phagocytes et des molécules de CMH-II liées aux cellules. Ces molécules interviennent également dans l'interaction entre un lipopolysaccharide ou LPS dans un complexe avec d'autres molécules, telles que CD14 et LBP (protéines de liaisons de LPS), et des molécules CMH-II liées aux cellules, ou dans l'interaction entre des produits provenant de bactéries Gram positif ou des complexes de produits provenant de bactéries Gram positif avec des molécules telles que CD14, et des molécules de CMH-II liées aux cellules. La molécule de fixation de CMH-II peut être n'importe quel anticorps ou fragment d'anticorps anti-CMH-II, ou n'importe quelle molécule dérivée de cet anticorps tel que des molécules humanisées, plus spécifiques ou autres molécules mises au point. La molécule de fixation de CMH-II peut être sélectionnée dans le groupe constitué par CD14, des fragments de celui-ci, des versions modifiées de celui-ci ou des peptides possédant des propriétés de fixation à CMH-II.
CA002208233A 1994-12-23 1995-12-27 Utilisation de molecules se fixant a cnh-ii et/ou simulant cnh-ii dans la prevention et/ou le traitement des etats inflammatoires Abandoned CA2208233A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94203755 1994-12-23
EP94203755.7 1994-12-23

Publications (1)

Publication Number Publication Date
CA2208233A1 true CA2208233A1 (fr) 1996-07-04

Family

ID=8217495

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002208233A Abandoned CA2208233A1 (fr) 1994-12-23 1995-12-27 Utilisation de molecules se fixant a cnh-ii et/ou simulant cnh-ii dans la prevention et/ou le traitement des etats inflammatoires

Country Status (11)

Country Link
EP (1) EP0800534A2 (fr)
JP (1) JPH10511652A (fr)
CN (1) CN1171117A (fr)
AU (1) AU4347696A (fr)
BR (1) BR9510554A (fr)
CA (1) CA2208233A1 (fr)
CZ (1) CZ186897A3 (fr)
HU (1) HUT77468A (fr)
PL (1) PL320922A1 (fr)
SK (1) SK80697A3 (fr)
WO (1) WO1996020215A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840835A (en) * 1995-10-30 1998-11-24 Merck & Co., Inc. Inhibitors of peptide binding to MHC class II proteins
US5719296A (en) * 1995-10-30 1998-02-17 Merck & Co., Inc. Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins
US5817757A (en) * 1995-10-30 1998-10-06 Merck & Co., Inc. Inhibitors of peptide binding to MHO class II proteins
EP0889964A1 (fr) 1996-03-28 1999-01-13 The Johns Hopkins University Analogues solubles heterodimeres divalents et multivalents de proteines
US6458354B1 (en) 1996-03-28 2002-10-01 The Johns Hopkins University Molecular complexes which modify immune responses
US6268411B1 (en) 1997-09-11 2001-07-31 The Johns Hopkins University Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses
EP0893507A1 (fr) * 1997-07-25 1999-01-27 Institut Gustave Roussy Utilisation de ligands de MHC classe II (CD4 et LAG-3) comme adjuvants pour la vaccination de LAG-3 dans le traitement du cancer
GB0201896D0 (en) * 2002-01-28 2002-03-13 Ice Biolog Ltd Treatment
HU228957B1 (en) * 2001-07-02 2013-07-29 Aimsco Ltd Use anti-hla-antibody for production of pharmaceutical compotisions for the treatment of diseases involving prolierative immune response
WO2003064472A2 (fr) * 2002-01-28 2003-08-07 Aimsco Limited Traitement
ES2232273B1 (es) * 2003-03-21 2006-07-16 Jose Manuel Fernandez-Real Lemos Nuevas aplicaciones terapeuticas de la glucoproteina cd14s.
WO2004103294A2 (fr) * 2003-05-15 2004-12-02 Tanox, Inc. Procedes et compositions pour la prevention et le traitement de la sepsie

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3269354D1 (en) * 1981-06-25 1986-04-03 Univ Leland Stanford Junior Allele specific immunotherapeutic method and dosage form
GB8310403D0 (en) * 1983-04-18 1983-05-25 Mach B F Cotransformed mouse cells
JPS6225994A (ja) * 1985-05-30 1987-02-03 ジエネテイツク　システムズ　コ−ポレイシヨン Ｈｌａタイプ分け用モノクロ−ナル抗体
JPS63275526A (ja) * 1987-05-03 1988-11-14 Hiroshi Okajima Ｈｉｖウイルス中和抗体
FR2658197B1 (fr) * 1990-02-14 1992-05-22 Inst Nat Sante Rech Med Anticorps monoclonaux restreints reconnaissant un peptide associe a un antigene du complexe majeur d'histocompatibilite - applications au diagnostic et au traitement.
DE4029227A1 (de) * 1990-09-14 1992-03-19 Imtox Gmbh Arzneimittel enthaltend cd14
WO1993010220A1 (fr) * 1991-11-19 1993-05-27 Anergen, Inc. Molecules solubles du complexe majeur d'histocompatibilite et leurs utilisations
WO1993019772A1 (fr) * 1992-04-06 1993-10-14 North Shore University Hospital Research Corporation Nouvelle therapie permettant de traiter la septicemie a l'aide d'une forme soluble de l'antigene myelomonocytique cd14 recombine
DE69332268T2 (de) * 1992-10-15 2003-08-14 Toray Industries, Inc. Verfahren zur herstellung von rekombinant mhcii protein in mikroorganismen
ATE335072T1 (de) * 1993-05-28 2006-08-15 Scripps Research Inst Methoden für inhibition der cd14-abhängigen zellaktivierung
US6180377B1 (en) * 1993-06-16 2001-01-30 Celltech Therapeutics Limited Humanized antibodies

Also Published As

Publication number Publication date
AU4347696A (en) 1996-07-19
HUT77468A (hu) 1998-05-28
WO1996020215A3 (fr) 1996-10-10
BR9510554A (pt) 1999-06-29
JPH10511652A (ja) 1998-11-10
PL320922A1 (en) 1997-11-10
EP0800534A2 (fr) 1997-10-15
WO1996020215A2 (fr) 1996-07-04
CN1171117A (zh) 1998-01-21
SK80697A3 (en) 1997-12-10
CZ186897A3 (cs) 1998-03-18

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Legal Events

Date Code Title Description
FZDE Discontinued