CA2237618C - Mch3, an apoptotic protease, nucleic acids encoding and methods of use - Google Patents

Mch3, an apoptotic protease, nucleic acids encoding and methods of use Download PDF

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Publication number: CA2237618C
Authority: CA; Canada
Prior art keywords: mch3; mch3a; seq; cpp32; functional fragment
Prior art date: 1995-11-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA2237618A

Other languages

English (en)

French (fr)

Other versions

CA2237618A1 (en

Inventor

Emad S. Alnemri

Teresa Fernandez-Alnemri

Gerald Litwack

Robert Armstrong

Kevin Tomaselli

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Thomas Jefferson University

Idun Pharmaceuticals Inc

Original Assignee

Thomas Jefferson University

Idun Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-13

Filing date

1996-11-12

Publication date

2011-04-19

1996-11-12 Application filed by Thomas Jefferson University, Idun Pharmaceuticals Inc filed Critical Thomas Jefferson University

1997-05-22 Publication of CA2237618A1 publication Critical patent/CA2237618A1/en

2011-04-19 Application granted granted Critical

2011-04-19 Publication of CA2237618C publication Critical patent/CA2237618C/en

2016-11-12 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

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239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
238000002823 phage display Methods 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
230000026731 phosphorylation Effects 0.000 description 1
238000006366 phosphorylation reaction Methods 0.000 description 1
239000013600 plasmid vector Substances 0.000 description 1
230000004481 post-translational protein modification Effects 0.000 description 1
238000011533 pre-incubation Methods 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
108010031719 prolyl-serine Proteins 0.000 description 1
108010004914 prolylarginine Proteins 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000002285 radioactive effect Effects 0.000 description 1
230000010837 receptor-mediated endocytosis Effects 0.000 description 1
238000010188 recombinant method Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
238000012163 sequencing technique Methods 0.000 description 1
239000003001 serine protease inhibitor Substances 0.000 description 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
238000002741 site-directed mutagenesis Methods 0.000 description 1
210000000813 small intestine Anatomy 0.000 description 1
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108010051110 tyrosyl-lysine Proteins 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
- C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Tea And Coffee (AREA)
Confectionery (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

CA2237618A 1995-11-13 1996-11-12 Mch3, an apoptotic protease, nucleic acids encoding and methods of use Expired - Lifetime CA2237618C (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/556,627		1995-11-13
US08/556,627 US6462175B1 (en)	1995-11-13	1995-11-13	Mch3, a novel apoptotic protease, nucleic acids encoding and methods of use
PCT/US1996/018118 WO1997018313A1 (en)	1995-11-13	1996-11-12	Mch3, an apoptotic protease, nucleic acids encoding and methods of use

Publications (2)

Publication Number	Publication Date
CA2237618A1 CA2237618A1 (en)	1997-05-22
CA2237618C true CA2237618C (en)	2011-04-19

Family

ID=24222154

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2237618A Expired - Lifetime CA2237618C (en)	1995-11-13	1996-11-12	Mch3, an apoptotic protease, nucleic acids encoding and methods of use

Country Status (9)

Country	Link
US (4)	US6462175B1 (de)
EP (1)	EP0866866B1 (de)
JP (1)	JP2000500338A (de)
AT (1)	ATE271609T1 (de)
AU (1)	AU728859C (de)
CA (1)	CA2237618C (de)
DE (1)	DE69632963T2 (de)
NZ (1)	NZ322796A (de)
WO (1)	WO1997018313A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7097972B1 (en)	1995-02-13	2006-08-29	Regents Of The University Of Michigan	Method and composition for regulating apoptosis
US6060238A (en) *	1995-02-13	2000-05-09	The Regents Of The University Of Michigan	Method and composition for regulating apoptosis
US6015665A (en) *	1995-02-13	2000-01-18	The Regents Of The University Of Michigan	Method and composition for regulating apoptosis
US6747138B1 (en)	1995-04-03	2004-06-08	Regents Of The University Of Michigan	Methods and compositions for regulating Fas-associated apoptosis
US7807783B1 (en)	1995-04-03	2010-10-05	The Regents Of The University Of Michigan	Methods and compositions for regulating FAS-associated apoptosis
US6462175B1 (en) *	1995-11-13	2002-10-08	Thomas Jefferson University	Mch3, a novel apoptotic protease, nucleic acids encoding and methods of use
DK0977846T3 (da)	1997-04-25	2002-10-14	Wyeth Corp	Neuronale MORT1-isoformer
US6270980B1 (en)	1997-06-05	2001-08-07	Idun Pharmaceuticals, Inc.	Rapid methods for identifying modifiers of cellular apoptosis activity
EP1232253A2 (de) *	1999-11-16	2002-08-21	Vertex Pharmaceuticals Incorporated	Caspase-7 enthaltende kristallisierbare zusammensetzungen
US20040241088A1 (en) *	2003-01-28	2004-12-02	Georgetown University	Method for evaluating the efficacy of certain cancer treatments

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6538121B1 (en)	1994-11-01	2003-03-25	Human Genome Sciences, Inc.	Interleukin-1 β converting enzyme like apoptosis protease-3 and 4
JPH11514883A (ja) *	1995-11-03	1999-12-21	バーテックスファーマシューティカルズインコーポレイテッド	アポトーシスに関与するシステインプロテアーゼ、ｃｍｈ−１をコードするｄｎａ配列
US6462175B1 (en) *	1995-11-13	2002-10-08	Thomas Jefferson University	Mch3, a novel apoptotic protease, nucleic acids encoding and methods of use

1995
- 1995-11-13 US US08/556,627 patent/US6462175B1/en not_active Expired - Lifetime
1996
- 1996-11-12 EP EP96939666A patent/EP0866866B1/de not_active Expired - Lifetime
- 1996-11-12 JP JP9518998A patent/JP2000500338A/ja active Pending
- 1996-11-12 AU AU76782/96A patent/AU728859C/en not_active Expired
- 1996-11-12 DE DE69632963T patent/DE69632963T2/de not_active Expired - Lifetime
- 1996-11-12 WO PCT/US1996/018118 patent/WO1997018313A1/en not_active Ceased
- 1996-11-12 NZ NZ322796A patent/NZ322796A/xx not_active IP Right Cessation
- 1996-11-12 AT AT96939666T patent/ATE271609T1/de not_active IP Right Cessation
- 1996-11-12 CA CA2237618A patent/CA2237618C/en not_active Expired - Lifetime
1998
- 1998-09-29 US US09/163,099 patent/US6686459B1/en not_active Expired - Lifetime
2001
- 2001-08-31 US US09/944,851 patent/US20020102648A1/en not_active Abandoned
2003
- 2003-01-02 US US10/337,060 patent/US6716960B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US20020102648A1 (en)	2002-08-01
NZ322796A (en)	1999-06-29
AU728859B2 (en)	2001-01-18
US6686459B1 (en)	2004-02-03
AU728859C (en)	2003-01-09
DE69632963T2 (de)	2005-07-28
ATE271609T1 (de)	2004-08-15
EP0866866A1 (de)	1998-09-30
US6716960B2 (en)	2004-04-06
AU7678296A (en)	1997-06-05
US6462175B1 (en)	2002-10-08
US20030119169A1 (en)	2003-06-26
DE69632963D1 (de)	2004-08-26
JP2000500338A (ja)	2000-01-18
EP0866866B1 (de)	2004-07-21
WO1997018313A1 (en)	1997-05-22
CA2237618A1 (en)	1997-05-22

Legal Events

Date	Code	Title	Description
2001-11-02	EEER	Examination request
2017-01-16	MKEX	Expiry	Effective date: 20161114

Publication	Publication Date	Title
CA2249233C (en)	2012-05-22	Mch4 and mch5, apoptotic protease, nucleic acids encoding and methods of use
US6716960B2 (en)	2004-04-06	Mch3, a novel apoptotic protease, nucleic acids encoding and methods of use
WO1997018313A9 (en)	1997-07-10	Mch3, an apoptotic protease, nucleic acids encoding and methods of use
US6340740B1 (en)	2002-01-22	Caspase-14, an apoptotic protease, nucleic acids encoding and methods of use
EP0814832A1 (de)	1998-01-07	Isoforme des menschlichen interleukin-1-g(b)-converting enzyms und methoden zu dessen verwendung
US5851815A (en)	1998-12-22	MCH4 and MCH5, apoptotic proteases
US6271361B1 (en)	2001-08-07	Apoptotic protease Mch6, nucleic acids encoding same and methods of use
JP5085570B2 (ja)	2012-11-28	Ｍｃｈ４およびＭｃｈ５、アポトーシス性プロテアーゼ、コードする核酸、および使用方法
US6642368B1 (en)	2003-11-04	Programmed cell death and caspase-12
AU720077B2 (en)	2000-05-25	DNA sequences encoding CMH-1, a cysteine protease involved in apoptosis
AU2922502A (en)	2002-05-16	Caspase-14, an apoptotic protease, nucleic acids encoding and methods of use