CA2243577A1 - Procede de purification et d'utilisation de proteines fixant l'erythropoietine - Google Patents

Procede de purification et d'utilisation de proteines fixant l'erythropoietine

Info

Publication number: CA2243577A1
Authority: CA; Canada
Prior art keywords: ebp; protein; epo; methods; binding
Prior art date: 1996-01-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA002243577A

Other languages

English (en)

Other versions

CA2243577C (fr

Inventor

Steven A. Middleton

Dana Johnson

Frank J. Mcmahon

Linda S. Mulkahy

Linda K. Jolliffe

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceuticals Inc

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-23

Filing date

1997-01-22

Publication date

1997-07-31

1997-01-22 Application filed by Individual filed Critical Individual

1997-01-22 Priority to CA002573196A priority Critical patent/CA2573196A1/fr

1997-01-22 Priority claimed from PCT/US1997/000932 external-priority patent/WO1997027219A1/fr

1997-07-31 Publication of CA2243577A1 publication Critical patent/CA2243577A1/fr

2007-06-05 Application granted granted Critical

2007-06-05 Publication of CA2243577C publication Critical patent/CA2243577C/fr

2017-01-22 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

238000000034 method Methods 0.000 title abstract 3
102000003951 Erythropoietin Human genes 0.000 title 1
108090000394 Erythropoietin Proteins 0.000 title 1
238000000746 purification Methods 0.000 title 1
102100031939 Erythropoietin Human genes 0.000 abstract 5
108010092408 Eosinophil Peroxidase Proteins 0.000 abstract 4
235000018102 proteins Nutrition 0.000 abstract 4
102000004169 proteins and genes Human genes 0.000 abstract 4
108090000623 proteins and genes Proteins 0.000 abstract 4
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 3
238000009510 drug design Methods 0.000 abstract 2
238000007876 drug discovery Methods 0.000 abstract 2
241000588724 Escherichia coli Species 0.000 abstract 1
101000852145 Homo sapiens Erythropoietin receptor Proteins 0.000 abstract 1
102000006496 Immunoglobulin Heavy Chains Human genes 0.000 abstract 1
108010019476 Immunoglobulin Heavy Chains Proteins 0.000 abstract 1
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
239000011543 agarose gel Substances 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
238000001516 cell proliferation assay Methods 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
238000002050 diffraction method Methods 0.000 abstract 1
238000006471 dimerization reaction Methods 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
108020001507 fusion proteins Proteins 0.000 abstract 1
102000037865 fusion proteins Human genes 0.000 abstract 1
230000003100 immobilizing effect Effects 0.000 abstract 1
230000003993 interaction Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000012528 membrane Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
239000002287 radioligand Substances 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
238000011084 recovery Methods 0.000 abstract 1
230000000638 stimulation Effects 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Toxicology (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cell Biology (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

CA002243577A 1996-01-23 1997-01-22 Procede de purification et d'utilisation de proteines fixant l'erythropoietine Expired - Lifetime CA2243577C (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA002573196A CA2573196A1 (fr)	1996-01-23	1997-01-22	Procede de purification et d'utilisation de proteines fixant l'erythropoietine

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US1046996P	1996-01-23	1996-01-23
US2212996P	1996-07-18	1996-07-18
US60/022,129		1996-07-18
US60/010,469		1996-07-18
PCT/US1997/000932 WO1997027219A1 (fr)	1996-01-23	1997-01-22	Procede de purification et d'utilisation de proteines fixant l'erythropoietine

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002573196A Division CA2573196A1 (fr)	1996-01-23	1997-01-22	Procede de purification et d'utilisation de proteines fixant l'erythropoietine

Publications (2)

Publication Number	Publication Date
CA2243577A1 true CA2243577A1 (fr)	1997-07-31
CA2243577C CA2243577C (fr)	2007-06-05

Family

ID=38137605

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002243577A Expired - Lifetime CA2243577C (fr)	1996-01-23	1997-01-22	Procede de purification et d'utilisation de proteines fixant l'erythropoietine

Country Status (1)

Country	Link
CA (1)	CA2243577C (fr)

1997
- 1997-01-22 CA CA002243577A patent/CA2243577C/fr not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2243577C (fr)	2007-06-05

Legal Events

Date	Code	Title	Description
2002-01-11	EEER	Examination request
2017-03-27	MKEX	Expiry	Effective date: 20170123

Publication	Publication Date	Title
ATE522610T1 (de)	2011-09-15	Menschliche, metabotrope glutamatrezeptor- subtypen (hmr6) und verwandte dns-verbindungen
Greenlund et al.	1993	Interferon-gamma induces receptor dimerization in solution and on cells.
EP0539530A4 (en)	1993-09-15	Purification directed cloning of peptides.
AU1986588A (en)	1989-01-04	Growth hormone receptor
IL124728A0 (en)	1999-01-26	Diagnosis and treatment of aur-1 and/or aur-2 related disorders
AU5390194A (en)	1994-07-28	Methods for regulating the immune response using CTLA4-binding molecules and IL4-binding molecules
IL107951A (en)	2003-12-10	Mammalian receptors for interleukin-10 (il-10)
EP0871703A4 (fr)	2000-03-01	Adn codant les canaux a chlorure a vanne glutamate
IL123189A0 (en)	1998-09-24	Colon cell and colon cancer cell associated nucleic acid molecules protein and peptides
ATE270330T1 (de)	2004-07-15	Alpha untereinheit des humanen beta-2 integrins
NZ296748A (en)	1999-11-29	Peripheral nervous system specific sodium channel proteins, DNA coding therefor, compositions and methods
DE69939330D1 (de)	2008-09-25	Wachstumsfaktor-homologe zvegf-3
EP1243597A3 (fr)	2004-05-06	Récepteurs pour l'interleukine-12 humaine
EP0909274A4 (fr)	2000-01-19	Procede de purification et d'utilisation de proteines fixant l'erythropoietine
CA2243577A1 (fr)	1997-07-31	Procede de purification et d'utilisation de proteines fixant l'erythropoietine
WO1996023884A3 (fr)	1996-10-03	Recepteurs humains actives par les proliferateurs du peroxisome
AU2818095A (en)	1996-12-24	Colon specific gene and protein
DK326289A (da)	1990-01-02	Fremgangsmaade til fremstilling af et protein ud fra gaersvampe under anvendelse af et inducerbart system, samt vektorer og transformerede stammer til brug ved fremgangsmaaden
EP0643728A4 (fr)	1995-07-19	Proteine apparentee aux molecules d'adhesion intercellulaire.
EP1331265A3 (fr)	2003-08-06	Protéine-tyrosine-phosphatases stimulées par la densité cellulaire
ATE272072T1 (de)	2004-08-15	Verfahren zur reinigung von menschlichem interleukin-1 rezeptor antagonist aus rekombinanten e.coli
ATE339448T1 (de)	2006-10-15	Verfahren zur trennung von glykosylierten und nicht-glykosylierten proteinen
CA2218755A1 (fr)	1997-08-28	Anticorps monoclonal anti-sous-unite alpha de l'integrine beta 2 humaine
WO1996023070A3 (fr)	1996-09-26	RECEPTEUR η DE RETINOIDE X HUMAIN (hRXR-GAMMA)
ATE260339T1 (de)	2004-03-15	Antikörper gegen menschliches restrictin