CA2245554C - Procede de production de rdspa .alpha.1 - Google Patents

Procede de production de rdspa .alpha.1 Download PDF

Info

Publication number
CA2245554C
CA2245554C CA002245554A CA2245554A CA2245554C CA 2245554 C CA2245554 C CA 2245554C CA 002245554 A CA002245554 A CA 002245554A CA 2245554 A CA2245554 A CA 2245554A CA 2245554 C CA2245554 C CA 2245554C
Authority
CA
Canada
Prior art keywords
rdspa
alpha
resin
buffer
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002245554A
Other languages
English (en)
Other versions
CA2245554A1 (fr
Inventor
Michael Mccaman
Erno Pungor
Carol Souders
Mei P. Tan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Intellectual Property GmbH
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/597,059 external-priority patent/US5731186A/en
Application filed by Schering AG filed Critical Schering AG
Publication of CA2245554A1 publication Critical patent/CA2245554A1/fr
Application granted granted Critical
Publication of CA2245554C publication Critical patent/CA2245554C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

On produit des quantités commerciales de rDSPA alpha possédant une pureté répondant à des normes cliniques. Le procédé de producti on met en application une série d'étapes chromatographiques, à savoir d'abord une chromatographie d'échanges de cations, suivie par une technique de chromatographie d'interaction hydrophobe et, enfin, une chromatographie d'affinité.
CA002245554A 1996-02-05 1997-01-31 Procede de production de rdspa .alpha.1 Expired - Lifetime CA2245554C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/597,059 1996-02-05
US08/597,059 US5731186A (en) 1996-02-05 1996-02-05 Method for the production of rDSPA α1
PCT/EP1997/000441 WO1997029188A1 (fr) 1996-02-05 1997-01-31 PROCEDE DE PRODUCTION DE rDSPA α1

Publications (2)

Publication Number Publication Date
CA2245554A1 CA2245554A1 (fr) 1997-08-14
CA2245554C true CA2245554C (fr) 2006-07-04

Family

ID=36648523

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002245554A Expired - Lifetime CA2245554C (fr) 1996-02-05 1997-01-31 Procede de production de rdspa .alpha.1

Country Status (1)

Country Link
CA (1) CA2245554C (fr)

Also Published As

Publication number Publication date
CA2245554A1 (fr) 1997-08-14

Similar Documents

Publication Publication Date Title
KR900008740B1 (ko) 혈청-비의존성 사람 세포주 및 이의 돌연변이 세포주를 제조하는 방법
JP2631645B2 (ja) 新規化合物、その製法及びそれを含む医薬組成物
JPH0378375B2 (fr)
US5187089A (en) Protease nexin-i variants which inhibit elastase
CA2105282C (fr) Preparation de facteur ix
AU706286B2 (en) Method for the production of rDSPA alpha1
US5432264A (en) Recombinant 3-des-OH-cystatin C produced by expression in a procaryotic host cell
CA2245554C (fr) Procede de production de rdspa .alpha.1
WO2012085933A1 (fr) Compositions pharmaceutiques de ténectéplase
KR900002345B1 (ko) 정상인의 결장세포로 부터 플라스미노겐 활성인자의 대량 생산방법
JPH0223158B2 (fr)
WO1990001333A1 (fr) PROCEDE DE PREPARATION DE COMPOSITIONS DE tPA
JPH07291999A (ja) 血小板安定化因子ｉｘ−フラグメント、その製造方法及びこれを含有する薬剤
HK1018795B (en) METHOD FOR THE PRODUCTION OF rDSPAα I
BG60507B2 (bg) Човешки тъканен плазминогенен активатор
JPS6391080A (ja) ヒト組織プラスミノゲン活性化因子の精製法
GB2153366A (en) Plasminogen activator
EP0307774A2 (fr) Procédé pour la purification de l'activateur du plaminogène
JPH02211870A (ja) 新規なポリペプチド

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20170131