CA2247246A1 - Compositions et procedes de traitement et de diagnostic des maladies cardio-vasculaires - Google Patents

Compositions et procedes de traitement et de diagnostic des maladies cardio-vasculaires Download PDF

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Publication number
CA2247246A1
CA2247246A1 CA002247246A CA2247246A CA2247246A1 CA 2247246 A1 CA2247246 A1 CA 2247246A1 CA 002247246 A CA002247246 A CA 002247246A CA 2247246 A CA2247246 A CA 2247246A CA 2247246 A1 CA2247246 A1 CA 2247246A1
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CA
Canada
Prior art keywords
gene
protein
cardiovascular disease
expression
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002247246A
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English (en)
Inventor
Dean A. Falb
Michael A. Gimbrone, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
The Brigham and Women's Hospital Inc
Millennium Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26682786&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2247246(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2247246A1 publication Critical patent/CA2247246A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention se rapporte à des procédés et à des compositions de traitement et de diagnotic de maladies cardio-vasculaires comprenant, mais pas exclusivement, l'athérosclérose, l'ischémie/reperfusion, l'hypertension, la resténose et l'inflammation artérielle. Dans cette invention on identifie et décrit notamment des gènes qui sont exprimés de manière différentielle dans des états pathologiques cardio-vasculaires, par rapport à leur expression dans des états pathologiques normaux ou non cardio-vasculaires, et/ou en réponse à des manipulations appropriées aux maladies cardio-vasculaires. En outre, dans cette invention on identifie et décrit des gènes par le biais de la capacité de leurs produits géniques à interagir avec les produits géniques impliqués dans les maladies cardio-vasculaires. L'invention se rapporte encore à des procédés d'identification et d'utilisation thérapeutique de composés dans les traitements des maladies cardio-vasculaires, des procédés de contrôle diagnostique de patients subissant des bilans cliniques en vue de traiter la maladie cardio-vasculaire, et à des procédés de contrôle de l'efficacité de ces composés dans les essais cliniques. L'invention se rapporte enfin à des procédés d'évaluation diagnostique et de pronostic de diverses maladies cardio-vasculaires, ainsi qu'à des procédés d'identification de sujets présentant une prédisposition à ces états.
CA002247246A 1996-02-16 1997-02-14 Compositions et procedes de traitement et de diagnostic des maladies cardio-vasculaires Abandoned CA2247246A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1178796P 1996-02-16 1996-02-16
US60/011,787 1996-02-16
US79991097A 1997-02-13 1997-02-13
US08/799,910 1997-02-13

Publications (1)

Publication Number Publication Date
CA2247246A1 true CA2247246A1 (fr) 1997-08-21

Family

ID=26682786

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002247246A Abandoned CA2247246A1 (fr) 1996-02-16 1997-02-14 Compositions et procedes de traitement et de diagnostic des maladies cardio-vasculaires

Country Status (6)

Country Link
US (7) US6759210B1 (fr)
EP (1) EP0904277A4 (fr)
JP (1) JP2001521365A (fr)
AU (1) AU725192B2 (fr)
CA (1) CA2247246A1 (fr)
WO (1) WO1997030065A1 (fr)

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Also Published As

Publication number Publication date
US6492126B2 (en) 2002-12-10
JP2001521365A (ja) 2001-11-06
US6048709A (en) 2000-04-11
US20020102603A1 (en) 2002-08-01
EP0904277A1 (fr) 1999-03-31
US20020016303A1 (en) 2002-02-07
US6087477A (en) 2000-07-11
US20020034736A1 (en) 2002-03-21
US6759210B1 (en) 2004-07-06
US6534641B2 (en) 2003-03-18
WO1997030065A1 (fr) 1997-08-21
US6221628B1 (en) 2001-04-24
AU725192B2 (en) 2000-10-05
AU2124397A (en) 1997-09-02
EP0904277A4 (fr) 2003-01-22

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Effective date: 20040216