CA2249011A1 - Bioconjugues de complexes de manganese ou de fer de ligands macrocycliques contenant de l'azote, efficaces comme catalyseurs pour la dismutation du superoxyde - Google Patents

Bioconjugues de complexes de manganese ou de fer de ligands macrocycliques contenant de l'azote, efficaces comme catalyseurs pour la dismutation du superoxyde Download PDF

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Publication number
CA2249011A1
CA2249011A1 CA002249011A CA2249011A CA2249011A1 CA 2249011 A1 CA2249011 A1 CA 2249011A1 CA 002249011 A CA002249011 A CA 002249011A CA 2249011 A CA2249011 A CA 2249011A CA 2249011 A1 CA2249011 A1 CA 2249011A1
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CA
Canada
Prior art keywords
alkyl
aryl
groups
attached
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002249011A
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English (en)
Inventor
William L. Neumann
Dennis P. Riley
Randy H. Weiss
Susan L. Henke
Patrick J. Lennon
Karl W. Aston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1996/012767 external-priority patent/WO1997006824A2/fr
Application filed by Individual filed Critical Individual
Publication of CA2249011A1 publication Critical patent/CA2249011A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des bioconjugués de faible poids moléculaire qui sont des mimétiques de la superoxyde dismutase (SOD) et qui sont représentés par la formule (I), où R, R', R¿1?, R'¿1?, R¿2?, R'¿2?, R¿3?; R'¿3?, R¿4?, R'¿4?, R¿5?, R'¿5?, R¿6?, R'¿6?, R¿7?, R'¿7?, R¿8?, R'¿8?, R¿9?, R'¿9?, X, Y, Z, M et n ont la signification donnée dans la description. Ces bioconjugués sont utiles comme agents thérapeutiques dans les états et les troubles inflammatoires tels que par lésions ischémiques/plaies de reperfusion, accident vasculaire cérébral, athérosclérose, ainsi que toutes les autres pathologies liées à des lésions ou des plaies tissulaires provoquées par des oxydants.
CA002249011A 1996-03-13 1997-03-04 Bioconjugues de complexes de manganese ou de fer de ligands macrocycliques contenant de l'azote, efficaces comme catalyseurs pour la dismutation du superoxyde Abandoned CA2249011A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1334896P 1996-03-13 1996-03-13
US60/013,348 1996-03-13
WOPCT/US96/12767 1996-08-14
PCT/US1996/012767 WO1997006824A2 (fr) 1995-08-17 1996-08-14 Bioconjugues de complexes de manganese et leur application comme catalyseurs

Publications (1)

Publication Number Publication Date
CA2249011A1 true CA2249011A1 (fr) 1997-09-18

Family

ID=21759507

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002249011A Abandoned CA2249011A1 (fr) 1996-03-13 1997-03-04 Bioconjugues de complexes de manganese ou de fer de ligands macrocycliques contenant de l'azote, efficaces comme catalyseurs pour la dismutation du superoxyde

Country Status (11)

Country Link
EP (1) EP0891338A1 (fr)
JP (1) JP2000508625A (fr)
KR (1) KR19990087784A (fr)
CN (1) CN1225631A (fr)
AU (1) AU1962497A (fr)
BR (1) BR9708179A (fr)
CA (1) CA2249011A1 (fr)
CZ (1) CZ271198A3 (fr)
IL (1) IL125889A0 (fr)
NO (1) NO984164L (fr)
WO (1) WO1997033877A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US6180620B1 (en) 1997-06-20 2001-01-30 G.D. Searle & Co. Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals
US6214817B1 (en) * 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
DE69813898T2 (de) 1997-11-03 2004-03-11 Duke University Substituierte porphyrinen
ATE312103T1 (de) 1999-01-25 2005-12-15 Nat Jewish Med & Res Center Substituierte porphyrine und deren therapeutische verwendungen
WO2000054784A1 (fr) * 1999-03-15 2000-09-21 Abdurafik Bakhramovich Akbarov Complexe comprenant le compose de coordination de manganese, ses effets therapeutiques et son procede de production
ES2240101T3 (es) 1999-05-27 2005-10-16 Monsanto Company Biomateriales modificados con mimeticos de superoxido dismutasa.
US20050176790A1 (en) 2001-02-28 2005-08-11 Johannes Bartholomaus Pharmaceutical salts
EP1439842A4 (fr) 2001-06-01 2009-09-02 Nat Jewish Med & Res Center Capteurs oxydants destines au traitement du diabete ou a etre utilises dans une transplantation ou a induire une tolerance immunitaire
WO2003103680A1 (fr) 2002-06-07 2003-12-18 Duke University Porphyrines substituees
AU2009246397B2 (en) 2008-05-13 2013-01-17 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
DK2300003T3 (da) 2008-05-23 2014-05-26 Nat Jewish Health Forbindelser til anvendelse i behandling af skade forbundet med eksponering for en alkylerende art
WO2013181461A2 (fr) 2012-06-01 2013-12-05 University Of Kansas Peptide de capture de métal avec une activité superoxyde dismutase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69224839T2 (de) * 1991-07-19 1998-10-08 Monsanto Co Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutasekatalysatoren.
HUT67602A (en) * 1991-12-10 1995-04-28 Dow Chemical Co Process for producing bicyclo-polyaza-macrocyclo-carboxylic acid complexes, their conjugates and contrast materials containing them
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
AU6031096A (en) * 1995-06-05 1996-12-24 Duke University Nitrosylated and nitrated superoxide oxidants and reductants
US6525041B1 (en) * 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
EP0830351A1 (fr) * 1995-06-07 1998-03-25 Monsanto Company Procede de preparation de polyazamacrocycles substitues

Also Published As

Publication number Publication date
IL125889A0 (en) 1999-04-11
NO984164D0 (no) 1998-09-10
KR19990087784A (ko) 1999-12-27
EP0891338A1 (fr) 1999-01-20
CZ271198A3 (cs) 1999-01-13
AU1962497A (en) 1997-10-01
WO1997033877A1 (fr) 1997-09-18
CN1225631A (zh) 1999-08-11
NO984164L (no) 1998-11-06
BR9708179A (pt) 1999-07-27
JP2000508625A (ja) 2000-07-11

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Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20010305