CA2260324A1 - Procede de preparation de polymeres bioactifs - Google Patents

Procede de preparation de polymeres bioactifs Download PDF

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Publication number
CA2260324A1
CA2260324A1 CA002260324A CA2260324A CA2260324A1 CA 2260324 A1 CA2260324 A1 CA 2260324A1 CA 002260324 A CA002260324 A CA 002260324A CA 2260324 A CA2260324 A CA 2260324A CA 2260324 A1 CA2260324 A1 CA 2260324A1
Authority
CA
Canada
Prior art keywords
cellulose
polymer
cover
wounds
reagent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002260324A
Other languages
English (en)
Inventor
Irene Burdygin
Shlomo Margel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bar Ilan University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2260324A1 publication Critical patent/CA2260324A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

La présente invention concerne un procédé de préparation d'un polymère bioactif, en liant par covalence un groupe amine contenant un ligand, à un ou plusieurs polymères contenant un ensemble de groupes hydroxyles, ledit procédé comportant les étapes suivantes : (i) réaction du ou desdits polymères avec un agent activant approprié, (ii) réaction du polymère activé résultant dans une solution aqueuse avec le groupe amine voulu contenant des ligands, (iii) blocage des groupes d'activation par réaction ou retrait par hydrolyse du polymère résiduel non réagi par liaison du ligand. Selon le procédé, ledit agent activant et/ou les sous-produits résiduels de l'étape (i) et/ou de l'étape (ii) et/ou de l'étape (iii) sont des agents de gonflement du polymère support.
CA002260324A 1996-07-14 1997-07-14 Procede de preparation de polymeres bioactifs Abandoned CA2260324A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL118848 1996-07-14
IL11884896A IL118848A0 (en) 1996-07-14 1996-07-14 Method for preparing bioactive polymers

Publications (1)

Publication Number Publication Date
CA2260324A1 true CA2260324A1 (fr) 1998-01-22

Family

ID=11069070

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002260324A Abandoned CA2260324A1 (fr) 1996-07-14 1997-07-14 Procede de preparation de polymeres bioactifs

Country Status (5)

Country Link
EP (1) EP0938340A2 (fr)
AU (1) AU3357497A (fr)
CA (1) CA2260324A1 (fr)
IL (1) IL118848A0 (fr)
WO (1) WO1998002189A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8595055B2 (en) 2001-03-27 2013-11-26 Points.Com Apparatus and method of facilitating the exchange of points between selected entities
US20060216267A1 (en) 2002-08-20 2006-09-28 Kovacs Stephen G Hydrophobic elastomeric polymer chemistry device for inhibiting the growth of onychomycosis and urushiol-induced allergic contact dermatitis
US7714065B2 (en) 2003-12-17 2010-05-11 The Procter & Gamble Company Polymeric structures comprising a hydrophile/lipophile system
US7426775B2 (en) 2003-12-17 2008-09-23 The Procter + Gamble Company Polymeric structures comprising a hydrophile/lipophile system
US7709439B2 (en) * 2004-02-20 2010-05-04 Boston Scientific Scimed, Inc. Biomaterials for enhanced healing
EP2399610A3 (fr) 2007-09-24 2012-09-05 Bar-Ilan University Nanoparticules en polymère recouvertes d'oxyde de métal magnétique et leurs utilisations
US8771725B2 (en) 2007-10-12 2014-07-08 Chesson Laboratory Associates, Inc. Poly(urea-urethane) compositions useful as topical medicaments and methods of using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH453269A4 (fr) * 1968-03-29 1973-01-31
US5475052A (en) * 1988-11-21 1995-12-12 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
FI912858A0 (fi) * 1988-12-20 1991-06-13 Jolla Cancer Res Found Polypeptidpolymerkonjugat aktiva vid botande av saor.
JPH04183392A (ja) * 1990-11-19 1992-06-30 Fuji Photo Film Co Ltd 生理活性物質を固定化した膜の製造方法
IL104734A0 (en) * 1993-02-15 1993-06-10 Univ Bar Ilan Bioactive conjugates of cellulose with amino compounds
ATE215106T1 (de) * 1993-12-01 2002-04-15 Bioartificial Gel Technologies Inc Hydrogel auf basis von albumin
IL111609A0 (en) * 1994-11-11 1995-01-24 Univ Bar Ilan Bioactive conjugates of polyhydroxy-polymers with amines

Also Published As

Publication number Publication date
EP0938340A2 (fr) 1999-09-01
AU3357497A (en) 1998-02-09
WO1998002189A2 (fr) 1998-01-22
WO1998002189A3 (fr) 1998-05-07
IL118848A0 (en) 1996-10-31

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Legal Events

Date Code Title Description
FZDE Discontinued
P22 Classification modified

Free format text: ST27 STATUS EVENT CODE: T-6-6-P10-P22-P110 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CLASSIFICATION MODIFIED

Effective date: 20240827