CA2283472A1 - Procede permettant d'antagoniser le domaine humain src sh2 - Google Patents
Procede permettant d'antagoniser le domaine humain src sh2 Download PDFInfo
- Publication number
- CA2283472A1 CA2283472A1 CA002283472A CA2283472A CA2283472A1 CA 2283472 A1 CA2283472 A1 CA 2283472A1 CA 002283472 A CA002283472 A CA 002283472A CA 2283472 A CA2283472 A CA 2283472A CA 2283472 A1 CA2283472 A1 CA 2283472A1
- Authority
- CA
- Canada
- Prior art keywords
- glu
- domain
- src
- peptidomimetic
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention concerne une méthode de traitement d'une maladie de résorption osseuse chez un patient, cette méthode consistant à administrer au sujet une dose thérapeutique efficace d'un composé qui forme une fixation ou une liaison covalente avec cys 185 du domaine src SH2. Les composés préférés pour une utilisation dans ladite méthode sont les composés de l'invention qui sont représentés par la formule (I) ou bien leur sel, hydrate ou solvate pharmaceutiquement acceptables. Dans la formule, X représente OR'', SR'', NR'', R'''; R'' représente H, méthyle, alkyle; R''' représente CONH¿2?, CONHMe, CO NHalkyle, SONH¿2?, SONHMe, SONH alkyle, SO¿2?NH¿2?, SO¿2?NHMe, SO¿2?NH alkyle; n représente 0,1 ou 2; R représente H, CH¿2?CH(NHCOR'''')CONHR'''''; une fraction organique; R'''' représente glu-glu-ileu-glu-NH¿2?, peptide, peptidomimétique, alkyle, alkyle substitué, aryle, aryle substitué, hétéroaryle, hétéroaryle substitué; R' représente H, peptidomimétique; ou R, R' représentent un système d'anneau fusionné substitué par H ou peptidomimétique. Cette invention concerne également une composition pharmaceutique contenant un excipient pharmaceutique approprié et un composé de formule (I).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4065897P | 1997-03-10 | 1997-03-10 | |
| US60/040,658 | 1997-03-10 | ||
| PCT/US1998/004699 WO1998040093A1 (fr) | 1997-03-10 | 1998-03-10 | Procede permettant d'antagoniser le domaine humain src sh2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2283472A1 true CA2283472A1 (fr) | 1998-09-17 |
Family
ID=21912217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002283472A Abandoned CA2283472A1 (fr) | 1997-03-10 | 1998-03-10 | Procede permettant d'antagoniser le domaine humain src sh2 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1007076A4 (fr) |
| JP (1) | JP2001514662A (fr) |
| CA (1) | CA2283472A1 (fr) |
| WO (1) | WO1998040093A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1457299A (en) | 1997-11-12 | 1999-05-31 | Ariad Pharmaceuticals, Inc. | Novel signal transduction inhibitors, compositions containing them |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5580979A (en) * | 1994-03-15 | 1996-12-03 | Trustees Of Tufts University | Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions |
| AU4440496A (en) * | 1995-02-10 | 1996-08-22 | Smithkline Beecham Corporation | Use of src SH2 specific compounds to treat a bone resorption disease |
-
1998
- 1998-03-10 CA CA002283472A patent/CA2283472A1/fr not_active Abandoned
- 1998-03-10 EP EP98910294A patent/EP1007076A4/fr not_active Withdrawn
- 1998-03-10 WO PCT/US1998/004699 patent/WO1998040093A1/fr not_active Ceased
- 1998-03-10 JP JP53972698A patent/JP2001514662A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1007076A1 (fr) | 2000-06-14 |
| JP2001514662A (ja) | 2001-09-11 |
| WO1998040093A1 (fr) | 1998-09-17 |
| EP1007076A4 (fr) | 2004-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDC | Correction of dead application (reinstatement) | ||
| FZDE | Dead |