CA2284119C - Proteine kinase a activite dependante du phosphatidyl-3,4,5-triphosphate - Google Patents

Proteine kinase a activite dependante du phosphatidyl-3,4,5-triphosphate Download PDF

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Publication number
CA2284119C
CA2284119C CA2284119A CA2284119A CA2284119C CA 2284119 C CA2284119 C CA 2284119C CA 2284119 A CA2284119 A CA 2284119A CA 2284119 A CA2284119 A CA 2284119A CA 2284119 C CA2284119 C CA 2284119C
Authority
CA
Canada
Prior art keywords
protein kinase
phosphoinositide
pkba
pdk1
kinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2284119A
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English (en)
Other versions
CA2284119A1 (fr
Inventor
Dario Renato Alessi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United Kingdom Research and Innovation
Original Assignee
Medical Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9705462.1A external-priority patent/GB9705462D0/en
Priority claimed from GBGB9712826.8A external-priority patent/GB9712826D0/en
Priority claimed from GBGB9717253.0A external-priority patent/GB9717253D0/en
Priority claimed from US08/943,667 external-priority patent/US6734001B1/en
Application filed by Medical Research Council filed Critical Medical Research Council
Publication of CA2284119A1 publication Critical patent/CA2284119A1/fr
Application granted granted Critical
Publication of CA2284119C publication Critical patent/CA2284119C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2284119A 1997-03-17 1998-03-16 Proteine kinase a activite dependante du phosphatidyl-3,4,5-triphosphate Expired - Lifetime CA2284119C (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GBGB9705462.1A GB9705462D0 (en) 1997-03-17 1997-03-17 Enzyme
GB9705462.1 1997-03-17
GBGB9712826.8A GB9712826D0 (en) 1997-06-19 1997-06-19 Enyzme
GB9712826.8 1997-06-19
GBGB9717253.0A GB9717253D0 (en) 1997-08-15 1997-08-15 Enzyme
GB9717253.0 1997-08-15
US08/943,667 US6734001B1 (en) 1997-03-17 1997-10-03 3-phosphoinositide-dependent protein kinase
US943,667 1997-10-03
PCT/GB1998/000777 WO1998041638A1 (fr) 1997-03-17 1998-03-16 Proteine kinase a activite dependante du phosphatidyl-3,4.5-triphosphate

Publications (2)

Publication Number Publication Date
CA2284119A1 CA2284119A1 (fr) 1998-09-24
CA2284119C true CA2284119C (fr) 2010-06-15

Family

ID=27451614

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2284119A Expired - Lifetime CA2284119C (fr) 1997-03-17 1998-03-16 Proteine kinase a activite dependante du phosphatidyl-3,4,5-triphosphate

Country Status (10)

Country Link
US (3) US7205390B2 (fr)
EP (1) EP0983363B1 (fr)
JP (2) JP3795535B2 (fr)
AT (1) ATE310825T1 (fr)
AU (1) AU734754B2 (fr)
CA (1) CA2284119C (fr)
DE (1) DE69832484T2 (fr)
DK (1) DK0983363T3 (fr)
ES (1) ES2256931T3 (fr)
WO (1) WO1998041638A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998041638A1 (fr) 1997-03-17 1998-09-24 Medical Research Council Proteine kinase a activite dependante du phosphatidyl-3,4.5-triphosphate
US6682920B1 (en) * 1997-09-26 2004-01-27 Onyx Pharmaceuticals, Inc. Compositions and methods for identifying PKB kinase inhibitors
CA2298854A1 (fr) * 1997-09-26 1999-04-08 Onyx Pharmaceuticals, Inc. Compositions et techniques permettant d'identifier les inhibiteurs de la kinase de la pkb
AU3591799A (en) * 1998-04-27 1999-11-16 University Health Network Gene screening methods and related assays
AU1789400A (en) * 1998-12-14 2000-07-03 Medical Research Council Screening methods
GB9906245D0 (en) * 1999-03-19 1999-05-12 Medical Res Council Enzyme
WO2001044497A2 (fr) * 1999-12-02 2001-06-21 University Of Dundee Regulation de la proteine kinase
GB0213186D0 (en) * 2002-06-08 2002-07-17 Univ Dundee Methods
US9580750B2 (en) * 2005-05-23 2017-02-28 The Johns Hopkins University P13K pathway mutations in cancer
EP2094837B1 (fr) * 2006-12-14 2012-04-25 Medical Research Council Utilisation d'inhibiteurs de pi3k, mtor et akt pour induire l'expression de foxp3 et générer des lymphocytes t régulateurs
EP2182058A1 (fr) 2008-10-17 2010-05-05 Universität des Saarlandes Structure de la protéine kinase PDK1 à haute résolution et effets allostériques d'activateurs à faible masse moléculaire

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5885777A (en) * 1994-10-13 1999-03-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Cloning, expression and characterization of a novel form of phosphatidylinositol-3-kinase
WO1998041638A1 (fr) 1997-03-17 1998-09-24 Medical Research Council Proteine kinase a activite dependante du phosphatidyl-3,4.5-triphosphate
US6734001B1 (en) 1997-03-17 2004-05-11 Medical Research Council 3-phosphoinositide-dependent protein kinase
US6682920B1 (en) * 1997-09-26 2004-01-27 Onyx Pharmaceuticals, Inc. Compositions and methods for identifying PKB kinase inhibitors
CA2298854A1 (fr) 1997-09-26 1999-04-08 Onyx Pharmaceuticals, Inc. Compositions et techniques permettant d'identifier les inhibiteurs de la kinase de la pkb

Also Published As

Publication number Publication date
EP0983363B1 (fr) 2005-11-23
DK0983363T3 (da) 2006-03-06
US20050032185A1 (en) 2005-02-10
JP3795535B2 (ja) 2006-07-12
ATE310825T1 (de) 2005-12-15
US20100093027A1 (en) 2010-04-15
JP2001516218A (ja) 2001-09-25
CA2284119A1 (fr) 1998-09-24
US7842488B2 (en) 2010-11-30
EP0983363A1 (fr) 2000-03-08
JP2005323611A (ja) 2005-11-24
WO1998041638A1 (fr) 1998-09-24
US20030108971A1 (en) 2003-06-12
ES2256931T3 (es) 2006-07-16
AU6412498A (en) 1998-10-12
AU734754B2 (en) 2001-06-21
DE69832484D1 (en) 2005-12-29
US7205390B2 (en) 2007-04-17
US7344870B2 (en) 2008-03-18
DE69832484T2 (de) 2006-08-10

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