CA2293712C - Urees cycliques benzo(5,6)cycloheptapyridine et lactames utiles comme inhibiteurs de farnesyl proteine transferase - Google Patents

Urees cycliques benzo(5,6)cycloheptapyridine et lactames utiles comme inhibiteurs de farnesyl proteine transferase Download PDF

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Publication number
CA2293712C
CA2293712C CA002293712A CA2293712A CA2293712C CA 2293712 C CA2293712 C CA 2293712C CA 002293712 A CA002293712 A CA 002293712A CA 2293712 A CA2293712 A CA 2293712A CA 2293712 C CA2293712 C CA 2293712C
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CA
Canada
Prior art keywords
compound
bromo
chloro
mmol
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002293712A
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English (en)
Other versions
CA2293712A1 (fr
Inventor
F. George Njoroge
Bancha Vibulbhan
Patrick A. Pinto
Viyyoor M. Girijavallabhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
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Publication date
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Publication of CA2293712A1 publication Critical patent/CA2293712A1/fr
Application granted granted Critical
Publication of CA2293712C publication Critical patent/CA2293712C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La présente invention concerne des composés représentés par la formule (I) destinés à inhiber la fonction Ras et donc à inhiber ou traiter la croissance anormale des cellules, ou un sel ou un solvate pharmaceutiquement acceptable de ceux-ci. Dans la formule (I), R et R?2¿ sont halo; R?1¿ et R?3¿ sont H et halo, pour autant qu'au moins un soit H; W est N, CH ou C lorsque la double liaison est présente à la position C-11; R?4¿ est -(CH¿2?)¿n?-R?5¿ ou (II); R?5¿ est (III); R?6¿ est R?5¿ ou (IV); Z?1¿ et Z?2¿ sont indépendamment sélectionnés dans le groupe constitué de =O et =S; n est 1-6; et n¿1? est 0 ou 1.
CA002293712A 1997-06-17 1998-06-15 Urees cycliques benzo(5,6)cycloheptapyridine et lactames utiles comme inhibiteurs de farnesyl proteine transferase Expired - Fee Related CA2293712C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/877,399 US5852034A (en) 1997-06-17 1997-06-17 Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors
US08/877,399 1997-06-17
PCT/US1998/011502 WO1998057963A1 (fr) 1997-06-17 1998-06-15 Urees cycliques benzo(5,6)cycloheptapyridine et lactames utiles comme inhibiteurs de farnesyl proteine transferase

Publications (2)

Publication Number Publication Date
CA2293712A1 CA2293712A1 (fr) 1998-12-23
CA2293712C true CA2293712C (fr) 2004-01-06

Family

ID=25369892

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002293712A Expired - Fee Related CA2293712C (fr) 1997-06-17 1998-06-15 Urees cycliques benzo(5,6)cycloheptapyridine et lactames utiles comme inhibiteurs de farnesyl proteine transferase

Country Status (14)

Country Link
US (2) US5852034A (fr)
EP (1) EP0991644B1 (fr)
JP (1) JP3515787B2 (fr)
KR (1) KR20010013892A (fr)
CN (1) CN1267297A (fr)
AT (1) ATE237611T1 (fr)
AU (1) AU744182B2 (fr)
CA (1) CA2293712C (fr)
DE (1) DE69813554T2 (fr)
ES (1) ES2195352T3 (fr)
HU (1) HUP0004521A3 (fr)
IL (1) IL133414A0 (fr)
NZ (1) NZ501570A (fr)
WO (1) WO1998057963A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524832B1 (en) * 1994-02-04 2003-02-25 Arch Development Corporation DNA damaging agents in combination with tyrosine kinase inhibitors
US6130229A (en) * 1996-10-09 2000-10-10 Schering Corporation Tricyclic compounds having activity as RAS-FPT inhibitors
US6211193B1 (en) * 1997-06-17 2001-04-03 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6632455B2 (en) 1997-12-22 2003-10-14 Schering Corporation Molecular dispersion composition with enhanced bioavailability
US6271378B1 (en) 1998-12-18 2001-08-07 Schering Corporation Process for preparing tricyclic compounds having antihistaminic activity
US6316462B1 (en) 1999-04-09 2001-11-13 Schering Corporation Methods of inducing cancer cell death and tumor regression
JP5491681B2 (ja) * 2000-02-04 2014-05-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 乳ガンの治療のためのファルネシルタンパク質トランスフェラーゼ阻害剤
EP1337522B1 (fr) 2000-11-29 2007-08-29 Schering Corporation Inhibiteurs de farnesyl proteine transferase
US20070148660A1 (en) * 2005-06-16 2007-06-28 The Regents Of The University Of California Treatment of maladaptive substance use with H-ras antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5661152A (en) * 1993-10-15 1997-08-26 Schering Corporation Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
AU4801197A (en) * 1996-09-13 1998-04-02 Schering Corporation Tricyclic antitumor compounds being farnesyl protein transferase inhibit ors

Also Published As

Publication number Publication date
DE69813554D1 (de) 2003-05-22
KR20010013892A (ko) 2001-02-26
JP2000513033A (ja) 2000-10-03
US6039683A (en) 2000-03-21
ES2195352T3 (es) 2003-12-01
EP0991644A1 (fr) 2000-04-12
HK1024909A1 (en) 2000-10-27
HUP0004521A3 (en) 2002-01-28
EP0991644B1 (fr) 2003-04-16
ATE237611T1 (de) 2003-05-15
JP3515787B2 (ja) 2004-04-05
NZ501570A (en) 2001-06-29
WO1998057963A1 (fr) 1998-12-23
US5852034A (en) 1998-12-22
AU7953898A (en) 1999-01-04
CA2293712A1 (fr) 1998-12-23
IL133414A0 (en) 2001-04-30
HUP0004521A2 (hu) 2001-10-28
CN1267297A (zh) 2000-09-20
DE69813554T2 (de) 2004-02-26
AU744182B2 (en) 2002-02-14

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