ATE237611T1 - Cyclische harnstoff- und lactamderivate von benzo(5,6)cycloheptapyridinen zur verwendung als farnesyl-protein-transferase-hemmer - Google Patents

Cyclische harnstoff- und lactamderivate von benzo(5,6)cycloheptapyridinen zur verwendung als farnesyl-protein-transferase-hemmer

Info

Publication number: ATE237611T1
Authority: AT; Austria
Prior art keywords: cycloheptapyridines; benzo; protein transferase; transferase inhibitors; cyclic urea
Prior art date: 1997-06-17

Application number

AT98930064T

Other languages

English (en)

Inventor

F George Njoroge

Bancha Vibulbhan

Patrick A Pinto

Viyyoor M Girijavallabhan

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-17

Filing date

1998-06-15

Publication date

2003-05-15

1998-06-15 Application filed by Schering Corp filed Critical Schering Corp

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE237611T1 publication Critical patent/ATE237611T1/de

Links

ZMGMDXCADSRNCX-UHFFFAOYSA-N 5,6-dihydroxy-1,3-diazepan-2-one Chemical class OC1CNC(=O)NCC1O ZMGMDXCADSRNCX-UHFFFAOYSA-N 0.000 title 1
150000003951 lactams Chemical class 0.000 title 1
239000003528 protein farnesyltransferase inhibitor Substances 0.000 title 1
125000001475 halogen functional group Chemical group 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
230000002159 abnormal effect Effects 0.000 abstract 1
230000010261 cell growth Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Enzymes And Modification Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT98930064T 1997-06-17 1998-06-15 Cyclische harnstoff- und lactamderivate von benzo(5,6)cycloheptapyridinen zur verwendung als farnesyl-protein-transferase-hemmer ATE237611T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/877,399 US5852034A (en)	1997-06-17	1997-06-17	Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors
PCT/US1998/011502 WO1998057963A1 (en)	1997-06-17	1998-06-15	Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors

Publications (1)

Publication Number	Publication Date
ATE237611T1 true ATE237611T1 (de)	2003-05-15

Family

ID=25369892

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98930064T ATE237611T1 (de)	1997-06-17	1998-06-15	Cyclische harnstoff- und lactamderivate von benzo(5,6)cycloheptapyridinen zur verwendung als farnesyl-protein-transferase-hemmer

Country Status (14)

Country	Link
US (2)	US5852034A (de)
EP (1)	EP0991644B1 (de)
JP (1)	JP3515787B2 (de)
KR (1)	KR20010013892A (de)
CN (1)	CN1267297A (de)
AT (1)	ATE237611T1 (de)
AU (1)	AU744182B2 (de)
CA (1)	CA2293712C (de)
DE (1)	DE69813554T2 (de)
ES (1)	ES2195352T3 (de)
HU (1)	HUP0004521A3 (de)
IL (1)	IL133414A0 (de)
NZ (1)	NZ501570A (de)
WO (1)	WO1998057963A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6524832B1 (en)	1994-02-04	2003-02-25	Arch Development Corporation	DNA damaging agents in combination with tyrosine kinase inhibitors
US6130229A (en) *	1996-10-09	2000-10-10	Schering Corporation	Tricyclic compounds having activity as RAS-FPT inhibitors
US6211193B1 (en) *	1997-06-17	2001-04-03	Schering Corporation	Compounds useful for inhibition of farnesyl protein transferase
US6632455B2 (en)	1997-12-22	2003-10-14	Schering Corporation	Molecular dispersion composition with enhanced bioavailability
US6271378B1 (en)	1998-12-18	2001-08-07	Schering Corporation	Process for preparing tricyclic compounds having antihistaminic activity
US6316462B1 (en)	1999-04-09	2001-11-13	Schering Corporation	Methods of inducing cancer cell death and tumor regression
EP1255537B1 (de) *	2000-02-04	2006-04-19	Janssen Pharmaceutica N.V.	Farnesyl protein transferase inhibitoren zur behandlung von brustkrebs
AR035660A1 (es)	2000-11-29	2004-06-23	Schering Corp	Compuestos 3,10-dibromo-8-cloro-11h-benzo[5,6]ciclohepta[1,2-b]piridin-11-il-4-piperidinilos o sus sales farmaceuticamente aceptables, composiciones farmaceuticas que los comprenden, usos de los mismos para preparar medicamentos, y un procedimiento para producir un compuesto intermediario para produ
US20070148660A1 (en) *	2005-06-16	2007-06-28	The Regents Of The University Of California	Treatment of maladaptive substance use with H-ras antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5089496A (en) *	1986-10-31	1992-02-18	Schering Corporation	Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5661152A (en) *	1993-10-15	1997-08-26	Schering Corporation	Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5719148A (en) *	1993-10-15	1998-02-17	Schering Corporation	Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) *	1993-10-15	2001-03-19	Schering Plough Corp	Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
KR20000036111A (ko) *	1996-09-13	2000-06-26	둘락 노먼 씨.	파네실 단백질 트랜스페라제 억제제인 트리사이클릭 항종양성화합물

1997
- 1997-06-17 US US08/877,399 patent/US5852034A/en not_active Expired - Lifetime
1998
- 1998-06-15 AU AU79538/98A patent/AU744182B2/en not_active Ceased
- 1998-06-15 AT AT98930064T patent/ATE237611T1/de not_active IP Right Cessation
- 1998-06-15 CA CA002293712A patent/CA2293712C/en not_active Expired - Fee Related
- 1998-06-15 DE DE69813554T patent/DE69813554T2/de not_active Expired - Lifetime
- 1998-06-15 CN CN98808187A patent/CN1267297A/zh active Pending
- 1998-06-15 ES ES98930064T patent/ES2195352T3/es not_active Expired - Lifetime
- 1998-06-15 HU HU0004521A patent/HUP0004521A3/hu unknown
- 1998-06-15 JP JP50449799A patent/JP3515787B2/ja not_active Expired - Fee Related
- 1998-06-15 EP EP98930064A patent/EP0991644B1/de not_active Expired - Lifetime
- 1998-06-15 WO PCT/US1998/011502 patent/WO1998057963A1/en not_active Ceased
- 1998-06-15 NZ NZ501570A patent/NZ501570A/en unknown
- 1998-06-15 KR KR1019997011914A patent/KR20010013892A/ko not_active Ceased
- 1998-06-15 IL IL13341498A patent/IL133414A0/xx unknown
- 1998-09-29 US US09/162,839 patent/US6039683A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HUP0004521A3 (en)	2002-01-28
US5852034A (en)	1998-12-22
DE69813554T2 (de)	2004-02-26
KR20010013892A (ko)	2001-02-26
AU744182B2 (en)	2002-02-14
EP0991644B1 (de)	2003-04-16
IL133414A0 (en)	2001-04-30
US6039683A (en)	2000-03-21
DE69813554D1 (de)	2003-05-22
HUP0004521A2 (hu)	2001-10-28
JP3515787B2 (ja)	2004-04-05
NZ501570A (en)	2001-06-29
AU7953898A (en)	1999-01-04
CN1267297A (zh)	2000-09-20
CA2293712A1 (en)	1998-12-23
WO1998057963A1 (en)	1998-12-23
EP0991644A1 (de)	2000-04-12
JP2000513033A (ja)	2000-10-03
ES2195352T3 (es)	2003-12-01
CA2293712C (en)	2004-01-06
HK1024909A1 (en)	2000-10-27

Legal Events

Date	Code	Title	Description
2003-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
AU554362B2 (en)	1986-08-21	Carboxyalkyl dipeptides
BG101833A (bg)	1998-04-30	Гуаниново производно
ES2082780T3 (es)	1996-04-01	Derivados de acido bisfosfonico heterociclicos.
TW368501B (en)	1999-09-01	7-(2-aminoethyl)-benzothiazolones
NZ332658A (en)	2000-05-26	Halo-substituted bis-indolylmaleimide derivatives and pharmaceutical compositions
ATE237611T1 (de)	2003-05-15	Cyclische harnstoff- und lactamderivate von benzo(5,6)cycloheptapyridinen zur verwendung als farnesyl-protein-transferase-hemmer
ATE209201T1 (de)	2001-12-15	Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren
NO991235L (no)	1999-05-10	Forbindelser anvendelige for inhibering av farnesylproteintransferase
MX9804828A (es)	1998-09-30	Benzotiazolona etanaminas biologicamente activas.
BG103271A (en)	2000-05-31	Derivatives of n-(benzothiazol-2-yl) piperidine-1-ethaneamines, method for their preparation and application as therapeutical means
DE69201184D1 (de)	1995-02-23	5- Piperazinylalkyl-1,5-Benzothiazepinone verwendbar als Calciumantagonisten.
UA26459C2 (uk)	1999-08-30	Іhгібітор впливу амілоїдhих білків
FI953618A0 (fi)	1995-07-28	Kondensoituneita heterosyklisiä glutamiinijohdannaisia antiproliferatiivisina aineina
ATE94050T1 (de)	1993-09-15	Mittel zur verhinderung von zahnbelagbildung.
DE3770481D1 (de)	1991-07-11	Verwendung von imidazochinazolinen zur behandlung und verhinderung von nephritis.
DE69528984D1 (de)	2003-01-09	Hemmung der leukotrienbiosynthese mittels harnstoffderivaten
AU1847401A (en)	2001-06-12	Diketopiperazine derivatives to inhibit thrombin
DE69724130D1 (de)	2003-09-18	Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl protein transferase inhibitoren
NO991231D0 (no)	1999-03-12	Forbindelser for inhibering av farnesylproteintransferase