CA2299687C - Formation, tributaire du ph, et a temperature controlee, de gels de polysaccharide ionique - Google Patents
Formation, tributaire du ph, et a temperature controlee, de gels de polysaccharide ionique Download PDFInfo
- Publication number
- CA2299687C CA2299687C CA002299687A CA2299687A CA2299687C CA 2299687 C CA2299687 C CA 2299687C CA 002299687 A CA002299687 A CA 002299687A CA 2299687 A CA2299687 A CA 2299687A CA 2299687 C CA2299687 C CA 2299687C
- Authority
- CA
- Canada
- Prior art keywords
- polysaccharide
- chitosan
- gel solution
- based gel
- phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 239000005017 polysaccharide Substances 0.000 title claims abstract description 87
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- 230000015572 biosynthetic process Effects 0.000 title claims abstract description 20
- 229920001661 Chitosan Polymers 0.000 claims abstract description 209
- 239000000243 solution Substances 0.000 claims abstract description 160
- 150000003839 salts Chemical class 0.000 claims abstract description 57
- 150000003077 polyols Chemical class 0.000 claims abstract description 37
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- 238000011065 in-situ storage Methods 0.000 claims abstract description 32
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- 230000007547 defect Effects 0.000 claims abstract description 10
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- 239000011369 resultant mixture Substances 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000001248 thermal gelation Methods 0.000 description 1
- 230000008542 thermal sensitivity Effects 0.000 description 1
- 230000009772 tissue formation Effects 0.000 description 1
- 239000012443 tonicity enhancing agent Substances 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/49—Phosphorus-containing compounds
- C08K5/51—Phosphorus bound to oxygen
- C08K5/52—Phosphorus bound to oxygen only
- C08K5/521—Esters of phosphoric acids, e.g. of H3PO4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002299687A CA2299687C (fr) | 1997-08-04 | 1998-04-06 | Formation, tributaire du ph, et a temperature controlee, de gels de polysaccharide ionique |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002212300A CA2212300A1 (fr) | 1997-08-04 | 1997-08-04 | Gelification in vitro ou in vivo du chitosane et utilisations therapeutiques du chitosane |
| CA2,212,300 | 1997-08-04 | ||
| CA002299687A CA2299687C (fr) | 1997-08-04 | 1998-04-06 | Formation, tributaire du ph, et a temperature controlee, de gels de polysaccharide ionique |
| PCT/CA1998/000326 WO1999007416A1 (fr) | 1997-08-04 | 1998-04-06 | FORMATION, TRIBUTAIRE DU pH, ET A TEMPERATURE CONTROLEE, DE GELS DE POLYSACCHARIDE IONIQUE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2299687A1 CA2299687A1 (fr) | 1999-02-18 |
| CA2299687C true CA2299687C (fr) | 2009-10-27 |
Family
ID=31888797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002299687A Expired - Lifetime CA2299687C (fr) | 1997-08-04 | 1998-04-06 | Formation, tributaire du ph, et a temperature controlee, de gels de polysaccharide ionique |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2299687C (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9200039B2 (en) | 2013-03-15 | 2015-12-01 | Symic Ip, Llc | Extracellular matrix-binding synthetic peptidoglycans |
| US9217016B2 (en) | 2011-05-24 | 2015-12-22 | Symic Ip, Llc | Hyaluronic acid-binding synthetic peptidoglycans, preparation, and methods of use |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20190691T1 (hr) | 2008-03-27 | 2019-07-12 | Purdue Research Foundation | Sintetički peptidoglikani koji vezuju kolagen, priprema, i postupci upotrebe |
| EA024569B1 (ru) * | 2010-08-27 | 2016-09-30 | Олиго Медик Инк. | Высокобиосовместимые композиции хитозана/солей глюкозамина с двусторонним термогелеобразованием |
| US8506972B2 (en) | 2010-08-27 | 2013-08-13 | Oligo Medic Inc | Highly biocompatible dual thermogelling chitosan/glucosamine salt compositions |
| WO2015164822A1 (fr) | 2014-04-25 | 2015-10-29 | Purdue Research Foundation | Peptidoglycanes synthétiques de liaison au collagène pour le traitement d'un dysfonctionnement endothélial |
| AU2018298224B2 (en) | 2017-07-07 | 2024-08-15 | Symic Ip, Llc | Synthetic bioconjugates |
| CN109957115A (zh) * | 2017-12-25 | 2019-07-02 | 成都昕才医药科技有限公司 | 一种温敏水凝胶 |
| CN114874039A (zh) * | 2022-05-18 | 2022-08-09 | 普洱学院 | 一种咖啡果皮有机肥料及其制备方法 |
| CN114948760A (zh) * | 2022-05-24 | 2022-08-30 | 上海家化联合股份有限公司 | 含有水杨酸的多糖基凝胶及其应用 |
-
1998
- 1998-04-06 CA CA002299687A patent/CA2299687C/fr not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9217016B2 (en) | 2011-05-24 | 2015-12-22 | Symic Ip, Llc | Hyaluronic acid-binding synthetic peptidoglycans, preparation, and methods of use |
| US9200039B2 (en) | 2013-03-15 | 2015-12-01 | Symic Ip, Llc | Extracellular matrix-binding synthetic peptidoglycans |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2299687A1 (fr) | 1999-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20180406 |