CA2302169A1 - Inhibiteurs du phenomene d'activation ne dependant pas de l'androgene et ayant un effet sur le recepteur de l'androgene - Google Patents
Inhibiteurs du phenomene d'activation ne dependant pas de l'androgene et ayant un effet sur le recepteur de l'androgene Download PDFInfo
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- CA2302169A1 CA2302169A1 CA002302169A CA2302169A CA2302169A1 CA 2302169 A1 CA2302169 A1 CA 2302169A1 CA 002302169 A CA002302169 A CA 002302169A CA 2302169 A CA2302169 A CA 2302169A CA 2302169 A1 CA2302169 A1 CA 2302169A1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'activation indépendante de l'androgène du récepteur d'androgène est localisée dans la région comprenant les acides aminés 234-391 de la protéine du récepteur d'androgène humain. L'invention concerne des peptides dérivés et des acides nucléiques codant pour ces peptides. Ces peptides sont utiles comme domaines d'activation, comme inhibiteurs de l'activation indépendante des androgènes du récepteur d'androgène, et comme agents thérapeutiques pour des pathologies d'origine androgénique telles que le cancer de la prostate. L'invention concerne en outre des procédés permettant la sélection de composés affectant l'activation indépendante de l'androgène du récepteur d'androgène.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9187198P | 1998-06-30 | 1998-06-30 | |
| US60/091,871 | 1998-06-30 | ||
| PCT/CA1999/000604 WO2000001813A2 (fr) | 1998-06-30 | 1999-06-30 | Inhibiteurs de l'activation independante de l'androgene du recepteur d'androgene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2302169A1 true CA2302169A1 (fr) | 2000-01-13 |
Family
ID=22230037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002302169A Abandoned CA2302169A1 (fr) | 1998-06-30 | 1999-06-30 | Inhibiteurs du phenomene d'activation ne dependant pas de l'androgene et ayant un effet sur le recepteur de l'androgene |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU4494399A (fr) |
| CA (1) | CA2302169A1 (fr) |
| WO (1) | WO2000001813A2 (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02012605A (es) | 2000-06-28 | 2003-05-14 | Squibb Bristol Myers Co | Moduladores selectivos del receptor androgeno y metodo para su identificacion, dise°o y uso. |
| JP2003018987A (ja) * | 2001-06-25 | 2003-01-21 | Okazaki National Research Institutes | 遺伝子導入細胞及びそれを用いた撹乱物質の検出法 |
| US20100189776A1 (en) | 2007-03-16 | 2010-07-29 | Cancer Research Technology Ltd | Anti-androgen peptides and uses thereof in cancer therapy |
| WO2009033212A1 (fr) * | 2007-09-11 | 2009-03-19 | Christopher Hovens | Utilisation de protéines de liaison aux œstrogènes et aux androgènes dans des procédés et compositions pour le traitement de cancers gynécologiques |
| FR2938334A1 (fr) * | 2008-11-13 | 2010-05-14 | Galderma Res & Dev | Modulateurs de l'adfp dans le traitement de l'acne, d'une dermatite seborrheique ou de l'hyperseborrhee |
| HUE034458T2 (en) | 2008-07-02 | 2018-02-28 | British Columbia Cancer Agency Branch | Diglycidyl ether derivatives, therapeutics and methods for their use |
| CN102131775B (zh) | 2008-08-22 | 2015-12-16 | 不列颠哥伦比亚癌症局分支机构 | 雄激素受体n-末端活化的小分子抑制剂 |
| US9388112B2 (en) | 2010-01-06 | 2016-07-12 | The University Of British Columbia | Bisphenol derivatives and their use as androgen receptor activity modulators |
| EP2693875A4 (fr) | 2011-04-08 | 2014-10-22 | British Columbia Cancer Agency | Composés de bisphénol et leurs procédés d'utilisation |
| US20130045204A1 (en) | 2011-08-19 | 2013-02-21 | The University Of British Columbia | Fluorinated bisphenol ether compounds and methods for their use |
| GB2496135B (en) * | 2011-11-01 | 2015-03-18 | Valirx Plc | Inhibitors of the interaction between a Src family kinase and an androgen receptor or estradiol receptor for treatment of endometriosis |
| US9365510B2 (en) | 2012-04-16 | 2016-06-14 | British Columbia Cancer Agency Branch | Aziridine bisphenol ethers and related compounds and methods for their use |
| GB2513615A (en) | 2013-05-01 | 2014-11-05 | Cancer Rec Tech Ltd | Medical use |
| AU2014262333B2 (en) | 2013-05-10 | 2016-06-16 | British Columbia Cancer Agency Branch | Ester derivatives of androgen receptor modulators and methods for their use |
| WO2015031984A1 (fr) | 2013-09-09 | 2015-03-12 | British Columbia Cancer Agency Branch | Composés halogénés pour imagerie et traitement du cancer, et procédés pour leur utilisation |
| AU2015266654A1 (en) | 2014-05-30 | 2016-12-01 | British Columbia Cancer Agency Branch | Androgen receptor modulators and methods for their use |
| DK3988541T3 (da) | 2015-01-13 | 2024-09-16 | British Columbia Cancer Agency Branch | Heterocycliske forbindelser til billedscanning og behandling af cancer samt fremgangsmåder til anvendelse af disse |
| WO2016141458A1 (fr) | 2015-03-12 | 2016-09-15 | British Columbia Cancer Agency Branch | Dérivés d'éther de bisphénol et leurs procédés d'utilisation |
| US20170298033A1 (en) | 2016-04-15 | 2017-10-19 | The University Of British Columbia | Bisphenol derivatives and their use as androgen receptor activity modulators |
| WO2018029517A1 (fr) * | 2016-08-08 | 2018-02-15 | Olipass Corporation | Oligonucléotides antisens du récepteur des androgènes |
| US11485713B2 (en) | 2018-05-25 | 2022-11-01 | Essa Pharma, Inc. | Androgen receptor modulators and methods for their use |
| WO2020081999A1 (fr) | 2018-10-18 | 2020-04-23 | Essa Pharma, Inc. | Modulateurs du récepteur des androgènes et leurs méthodes d'utilisation |
| WO2020198712A1 (fr) | 2019-03-28 | 2020-10-01 | Essa Pharma, Inc. | Compositions et combinaisons pharmaceutiques comprenant des inhibiteurs du récepteur des androgènes et utilisations de celles-ci |
| CN115916170A (zh) | 2020-04-17 | 2023-04-04 | 埃萨制药股份有限公司 | 固体形式的n-末端结构域雄激素受体抑制剂及其用途 |
| WO2023046283A1 (fr) | 2021-09-22 | 2023-03-30 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | Composés et leur utilisation dans une méthode de modulation de l'activité transcriptionnelle d'ar (récepteur des androgènes) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6307030B1 (en) * | 1988-04-15 | 2001-10-23 | The University Of North Carolina At Chapel Hill | Androgen receptor proteins, recombinant DNA molecules coding for such, and use of such compositions |
| EP0577932A3 (fr) * | 1992-05-08 | 1995-04-19 | American Cyanamid Co | Développement d'un "screening" basé en mécanisme pour identifier agonistes et antagonistes du récepteur d'androgène. |
| US6184205B1 (en) * | 1994-07-22 | 2001-02-06 | University Of North Carolina At Chapel Hill | GRB2 SH3 binding peptides and methods of isolating and using same |
-
1999
- 1999-06-30 CA CA002302169A patent/CA2302169A1/fr not_active Abandoned
- 1999-06-30 AU AU44943/99A patent/AU4494399A/en not_active Abandoned
- 1999-06-30 WO PCT/CA1999/000604 patent/WO2000001813A2/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000001813A2 (fr) | 2000-01-13 |
| AU4494399A (en) | 2000-01-24 |
| WO2000001813A3 (fr) | 2000-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |