CA2303797A1 - Procede de production d'intermediaires d'epoxydes - Google Patents

Procede de production d'intermediaires d'epoxydes Download PDF

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Publication number
CA2303797A1
CA2303797A1 CA002303797A CA2303797A CA2303797A1 CA 2303797 A1 CA2303797 A1 CA 2303797A1 CA 002303797 A CA002303797 A CA 002303797A CA 2303797 A CA2303797 A CA 2303797A CA 2303797 A1 CA2303797 A1 CA 2303797A1
Authority
CA
Canada
Prior art keywords
ring
aliphatic ring
lower alkyl
prostaglandin
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002303797A
Other languages
English (en)
Inventor
Mitchell Anthony Delong
Yili Wang
Biswanath De
Jack S. Amburgey, Jr.
Haiyan George Dai
John August Wos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2303797A1 publication Critical patent/CA2303797A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)

Abstract

On a découvert avec surprise que les inconvénients des longues procédures actuellement documentées pour synthétiser les dérivés 13,14-dihydro de prostaglandine A, E et F peuvent être éliminés grâce à un intermédiaire d'heptanoate de méthyle 7-(2-hydroxy-5-(2-(2-oxiranyl)éthyl)-4-(1,1,2,2-tétraméthyl-1-silapropoxy)cyclopentyl), qui peut être synthétisé à partir d'heptanoate de méthyle 7-[3-(R)-hydroxy-5-oxo-1-cyclopent-1-yl] disponible dans le commerce. Ce nouvel intermédiaire peut être couplé à des nucléophiles d'oxygène, de carbone, de soufre et d'azote, en présence d'une base ou d'un acide de Lewis, dans un procédé à ouverture de cycle, pour fournir des dérivés 13,14-dihydro de prostaglandine A, E et F.
CA002303797A 1997-09-09 1998-09-04 Procede de production d'intermediaires d'epoxydes Abandoned CA2303797A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5825497P 1997-09-09 1997-09-09
US60/058,254 1997-09-09
PCT/US1998/018593 WO1999012897A1 (fr) 1997-09-09 1998-09-04 Procede de production d'intermediaires d'epoxydes

Publications (1)

Publication Number Publication Date
CA2303797A1 true CA2303797A1 (fr) 1999-03-18

Family

ID=22015649

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002303797A Abandoned CA2303797A1 (fr) 1997-09-09 1998-09-04 Procede de production d'intermediaires d'epoxydes

Country Status (16)

Country Link
US (1) US6066751A (fr)
EP (1) EP1012138A1 (fr)
JP (1) JP2001515884A (fr)
CN (1) CN1269783A (fr)
AU (1) AU9305798A (fr)
BR (1) BR9811771A (fr)
CA (1) CA2303797A1 (fr)
HU (1) HUP0003578A2 (fr)
ID (1) ID24840A (fr)
IL (1) IL134864A0 (fr)
NO (1) NO20001140L (fr)
PE (1) PE121499A1 (fr)
PL (1) PL339220A1 (fr)
SK (1) SK3392000A3 (fr)
TR (1) TR200000672T2 (fr)
WO (1) WO1999012897A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000051980A1 (fr) 1999-03-05 2000-09-08 The Procter & Gamble Company Analogues de prostaglandines c16 fp selectives insaturees
US6894175B1 (en) 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
KR100437873B1 (ko) * 2001-05-08 2004-06-26 연성정밀화학(주) 프로스타글란딘 유도체의 제조방법 및 그의 입체특이적출발물질

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3776938A (en) * 1958-05-28 1973-12-04 S Bergstrom Dihydro-pge1
US3505386A (en) * 1965-12-29 1970-04-07 Upjohn Co Compounds related to prostaglandins
US3435053A (en) * 1966-06-06 1969-03-25 Upjohn Co Cyclopenta(b)pyrans

Also Published As

Publication number Publication date
EP1012138A1 (fr) 2000-06-28
WO1999012897A1 (fr) 1999-03-18
BR9811771A (pt) 2000-08-29
CN1269783A (zh) 2000-10-11
SK3392000A3 (en) 2000-09-12
IL134864A0 (en) 2001-05-20
PL339220A1 (en) 2000-12-04
JP2001515884A (ja) 2001-09-25
TR200000672T2 (tr) 2000-07-21
HUP0003578A2 (hu) 2001-02-28
US6066751A (en) 2000-05-23
PE121499A1 (es) 2000-02-03
ID24840A (id) 2000-08-24
NO20001140L (no) 2000-05-04
NO20001140D0 (no) 2000-03-06
AU9305798A (en) 1999-03-29

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued