CA2304117A1 - Integrin receptor antagonists - Google Patents

Integrin receptor antagonists Download PDF

Info

Publication number: CA2304117A1
Authority: CA; Canada
Prior art keywords: 6alkyl; compound according; 4alkyl; compound; compounds
Prior art date: 1997-09-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002304117A

Other languages

English (en)

French (fr)

Inventor

Dirk A. Heerding

James M. Samanen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-04

Filing date

1998-09-03

Publication date

1999-03-11

1998-09-03 Application filed by Individual filed Critical Individual

1999-03-11 Publication of CA2304117A1 publication Critical patent/CA2304117A1/en

Status Abandoned legal-status Critical Current

Links

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OGBMKVWORPGQRR-UMXFMPSGSA-N teriparatide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CNC=N1 OGBMKVWORPGQRR-UMXFMPSGSA-N 0.000 description 1
ROKMMRDVGWRMKJ-UHFFFAOYSA-N tert-butyl 2-amino-3-(3-hydroxypropyl)-2h-pyridine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1C=CC=C(CCCO)C1N ROKMMRDVGWRMKJ-UHFFFAOYSA-N 0.000 description 1
238000012360 testing method Methods 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 description 1
CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
150000003573 thiols Chemical class 0.000 description 1
229930192474 thiophene Natural products 0.000 description 1
230000009424 thromboembolic effect Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
238000002054 transplantation Methods 0.000 description 1
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125000004950 trifluoroalkyl group Chemical group 0.000 description 1
210000001364 upper extremity Anatomy 0.000 description 1
210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
108010047303 von Willebrand Factor Proteins 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

CA002304117A 1997-09-04 1998-09-03 Integrin receptor antagonists Abandoned CA2304117A1 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US5752997P	1997-09-04	1997-09-04
US6352097P	1997-10-29	1997-10-29
US60/057,529		1997-10-29
US60/063,520		1997-10-29
PCT/US1998/018379 WO1999011626A1 (en)	1997-09-04	1998-09-03	Integrin receptor antagonists

Publications (1)

Publication Number	Publication Date
CA2304117A1 true CA2304117A1 (en)	1999-03-11

Family

ID=26736601

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002304117A Abandoned CA2304117A1 (en)	1997-09-04	1998-09-03	Integrin receptor antagonists

Country Status (4)

Country	Link
EP (1)	EP1027337A4 (de)
JP (1)	JP2001514253A (de)
CA (1)	CA2304117A1 (de)
WO (1)	WO1999011626A1 (de)

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AU747503B2 (en)	1999-02-03	2002-05-16	Merck & Co., Inc.	Benzazepine derivatives as alpha-V integrin receptor antagonists
JP2002537260A (ja) *	1999-02-17	2002-11-05	メルクエンドカムパニーインコーポレーテッド	αＶインテグリン受容体拮抗薬としてのジベンゾ−アゼピン誘導体
JP2003506452A (ja) *	1999-08-06	2003-02-18	スミスクライン・ビーチャム・コーポレイション	発作の治療に有用なビトロネクチン受容体アンタゴニスト
DE19936780A1 (de)	1999-08-09	2001-02-15	Basf Ag	Neue Antagonisten von Integrinrezeptoren
US6514964B1 (en)	1999-09-27	2003-02-04	Amgen Inc.	Fused cycloheptane and fused azacycloheptane compounds and their methods of use
DE10039998A1 (de) *	2000-08-11	2002-02-21	Basf Ag	Neue substituierte Diareno-azepin-Derivate als Integrin Liganden
CA2386457A1 (en) *	1999-10-06	2001-04-12	Basf Aktiengesellschaft	Inhibitors of the endothelin signalling pathway and .alpha.v.beta.3 integrin receptor antagonists for combination therapy
DE10028575A1 (de)	2000-06-14	2002-03-14	Basf Ag	Integrinliganden
EP1381384B1 (de)	2001-04-24	2011-05-25	Merck Patent GmbH	KOMBINATIONSTHERAPIE MIT ANTIANGIOGENEN MITTELN UND TNFalpha
DE102004004928A1 (de) *	2004-01-31	2005-08-18	Bayer Healthcare Ag	Dibenzoxazepine II
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
EP1973569B1 (de)	2006-01-18	2013-05-22	Merck Patent GmbH	Spezifische therapie mit integrin-liganden zur krebsbehandlung
JP2010516645A (ja)	2007-01-18	2010-05-20	メルクパテントゲゼルシャフトミットベシュレンクテルハフツング	癌を治療するためのインテグリンリガンドを用いる特異的療法および薬剤
US20120130146A1 (en)	2009-05-25	2012-05-24	Merck Patent Gmbh	Continuous administration of cilengitide in cancer treatments
ES2864079T3 (es)	2014-05-30	2021-10-13	Pfizer	Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
WO2023275715A1 (en)	2021-06-30	2023-01-05	Pfizer Inc.	Metabolites of selective androgen receptor modulators

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BE632563A (de) *	1963-03-26
NL127795C (de) *	1966-01-28
US3905977A (en) *	1974-12-06	1975-09-16	Carter Wallace	Octahydromorphanthridines
IT1207417B (it) *	1982-03-15	1989-05-17	Menarini Sas	Azepina-6-one ad attivita'composti triciclici derivati dalla farmacologica, e procedimenti di 5,6-diidro-11h-dibenzo (b,e)fabbricazione relativi
EP0419861B1 (de) *	1989-08-29	1995-11-02	Boehringer Ingelheim Pharmaceuticals Inc.	Verwendung von Dibenzo[b,f][1,4]oxazepin (und thiazepin)-11(10H)-one und -thione zur Herstellung eines Arzneimittels zur Prävention und Behandlung von AIDS
US5493020A (en) *	1993-07-29	1996-02-20	Genentech, Inc.	Tricyclic inhibitors of the GPIIb IIIa receptor
US5512563A (en) *	1993-07-29	1996-04-30	American Cyanamid Company	Tricyclic benzazepine vasopressin antagonists
EP0910563B1 (de) *	1995-06-29	2003-05-02	Smithkline Beecham Corporation	Integrin-rezeptor-antagonisten
CO4920232A1 (es) *	1997-01-08	2000-05-29	Smithkline Beecham Corp	Acidos aceticos dibenzo [a,d] cicloheptano con actividad antagonista del receptor de vitronectin

1998
- 1998-09-03 WO PCT/US1998/018379 patent/WO1999011626A1/en not_active Ceased
- 1998-09-03 JP JP2000508666A patent/JP2001514253A/ja not_active Withdrawn
- 1998-09-03 CA CA002304117A patent/CA2304117A1/en not_active Abandoned
- 1998-09-03 EP EP98944735A patent/EP1027337A4/de not_active Withdrawn

Also Published As

Publication number	Publication date
WO1999011626A1 (en)	1999-03-11
EP1027337A4 (de)	2002-04-03
JP2001514253A (ja)	2001-09-11
EP1027337A1 (de)	2000-08-16

Legal Events

Date	Code	Title	Description
2004-09-03	FZDE	Dead

Publication	Publication Date	Title
CA2192764C (en)	2008-03-11	Integrin receptor antagonists
WO1999006049A1 (en)	1999-02-11	Integrin receptor antagonists
EP0762882A1 (de)	1997-03-19	Vibronectin-rezeptor-antagonisten
US6239138B1 (en)	2001-05-29	Vitronectin receptor antagonist
US6159964A (en)	2000-12-12	Vitronectin receptor antagonists
AU702661B2 (en)	1999-02-25	Vitronectin receptor antagonists
CA2304117A1 (en)	1999-03-11	Integrin receptor antagonists
US5741804A (en)	1998-04-21	Substituted benzimazoles which inhibit platelet aggrecation
WO1996026190A1 (en)	1996-08-29	Integrin receptor antagonists
EP0702671A1 (de)	1996-03-27	Bicyclische fibrinogen-antagonisten
EP0869787A1 (de)	1998-10-14	Vitronectinrezeptorantagonisten
US6117910A (en)	2000-09-12	Bicyclic fibrinogen antagonists
US5977101A (en)	1999-11-02	Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
US6008213A (en)	1999-12-28	Integrin receptor antagonists
EP1102587A2 (de)	2001-05-30	Vitronectinrezeptorantagonisten
CA2124169A1 (en)	1995-11-25	Chemical compounds
US6458784B1 (en)	2002-10-01	Vitronectin receptor antagonists
US20020055499A1 (en)	2002-05-09	Integrin receptor antagonists
KR100459621B1 (ko)	2005-09-02	인테그린수용체길항제
HK1019594B (en)	2003-12-24	Integrin receptor antagonists
PL191595B1 (pl)	2006-06-30	Antagoniści receptorów integryny i kompozycje je zawierające
CA2241755A1 (en)	1997-07-10	Vitronectin receptor antagonists
MXPA98005254A (en)	1999-02-24	Vitronect receptor antagonists