CA2305341C - Stabilisation des glycoproteines trimeres d'enveloppe au moyen de liaisons bisulfure introduites dans un ectodomaine de la glycoproteine gp41 - Google Patents

Stabilisation des glycoproteines trimeres d'enveloppe au moyen de liaisons bisulfure introduites dans un ectodomaine de la glycoproteine gp41 Download PDF

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Publication number
CA2305341C
CA2305341C CA002305341A CA2305341A CA2305341C CA 2305341 C CA2305341 C CA 2305341C CA 002305341 A CA002305341 A CA 002305341A CA 2305341 A CA2305341 A CA 2305341A CA 2305341 C CA2305341 C CA 2305341C
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CA
Canada
Prior art keywords
hiv
protein
derivative
glycoprotein
coiled coil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002305341A
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English (en)
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CA2305341A1 (fr
Inventor
Joseph G. Sodroski
Michael Farzan
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Publication of CA2305341A1 publication Critical patent/CA2305341A1/fr
Application granted granted Critical
Publication of CA2305341C publication Critical patent/CA2305341C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention se rapporte à des glycoprotéines trimères d'enveloppe stabilisés. Ces trimères sont stabilisés par l'introduction de liaisons bisulfure dans certains sites de l'ectodomaine de gp41. On peut utiliser les molécules d'ADN codant ces trimères pour déclencher une réponse immunogénique.
CA002305341A 1997-10-01 1998-10-01 Stabilisation des glycoproteines trimeres d'enveloppe au moyen de liaisons bisulfure introduites dans un ectodomaine de la glycoproteine gp41 Expired - Fee Related CA2305341C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6081397P 1997-10-01 1997-10-01
US60/060,813 1997-10-01
US6080897P 1997-10-03 1997-10-03
US60/060,808 1997-10-03
PCT/US1998/020693 WO1999016883A2 (fr) 1997-10-01 1998-10-01 Stabilisation des glycoproteines trimeres d'enveloppe au moyen de liaisons bisulfure introduites dans un ectodomaine de la glycoproteine gp41

Publications (2)

Publication Number Publication Date
CA2305341A1 CA2305341A1 (fr) 1999-04-08
CA2305341C true CA2305341C (fr) 2009-01-06

Family

ID=26740384

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002305341A Expired - Fee Related CA2305341C (fr) 1997-10-01 1998-10-01 Stabilisation des glycoproteines trimeres d'enveloppe au moyen de liaisons bisulfure introduites dans un ectodomaine de la glycoproteine gp41

Country Status (4)

Country Link
EP (1) EP1019511A2 (fr)
AU (1) AU9678598A (fr)
CA (1) CA2305341C (fr)
WO (1) WO1999016883A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2781676B1 (fr) * 1998-07-31 2004-04-02 Pasteur Merieux Serums Vacc Trimere du produit d'expression du gene env de hiv
AU2221600A (en) 1998-12-31 2000-07-31 Chiron Corporation Improved expression of hiv polypeptides and production of virus-like particles
CA2384271A1 (fr) 1999-09-17 2001-03-22 Joseph G. Sodroski Trimeres stabilises solubles de glycoproteines
US7179468B1 (en) 2000-06-08 2007-02-20 Cornell Research Foundation, Inc. Antigen for developing neutralizing antibodies to human immunodeficiency virus
CA2431212A1 (fr) * 2000-12-27 2002-07-25 Richard T. Wyatt Proteoliposomes immunogenes et applications de ceux-ci
EP2412242A3 (fr) 2001-07-05 2012-06-13 Novartis Vaccines and Diagnostics, Inc. Polynucléotides codant pour des polypeptides antigènes de type C du VIH, polypeptides et leurs utilisations
US20030170614A1 (en) 2001-08-31 2003-09-11 Megede Jan Zur Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
US7811577B2 (en) 2004-06-01 2010-10-12 Merck Sharp & Dohme Corp. Covalently stabilized chimeric coiled-coil HIV gp41 N-peptides with improved antiviral activity
ES2324755B1 (es) * 2007-04-04 2010-05-31 Consejo Superior De Investigaciones Cientificas (Csic) Polipeptido de la proteina gp120 capaz de inhibir el ciclo vital del virus del sida.
ATE538129T1 (de) 2007-09-07 2012-01-15 Complix N V Nicht natürliches proteinöses gerüst aus drei nicht kovalent assoziierten peptiden
EP2161278B1 (fr) * 2008-09-08 2012-05-23 Complix N.V. Échafaudage à bobine à une seule chaîne
EP3303367B1 (fr) * 2015-06-08 2025-06-18 New York University Mimétiques de superenroulement minimal stabilisés
US11891422B2 (en) 2018-11-16 2024-02-06 New York University NEMO coiled coil mimics and methods of using same
CN110184298B (zh) * 2019-05-15 2023-05-16 武汉璟泓科技股份有限公司 Hiv突变型表面糖蛋白及其纳米化抗原与制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704694A (en) 1985-12-16 1987-11-03 Automation Intelligence, Inc. Learned part system
US4976778A (en) 1988-03-08 1990-12-11 Scm Metal Products, Inc. Infiltrated powder metal part and method for making same
KR100252547B1 (ko) 1991-09-05 2000-09-01 프레드 마리얀스키 폴리-또는 올리고누클레오티드의 세포로의 표적화된 전달
WO1995022618A1 (fr) 1994-02-22 1995-08-24 Dana-Farber Cancer Institute Systeme de liberation d'acide nucleique, son procede de synthese et ses utilisations

Also Published As

Publication number Publication date
WO1999016883A2 (fr) 1999-04-08
WO1999016883A3 (fr) 1999-06-17
EP1019511A2 (fr) 2000-07-19
AU9678598A (en) 1999-04-23
CA2305341A1 (fr) 1999-04-08

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