CA2307541A1 - Immunomodulateurs encapsules utilises comme adjuvants de vaccins - Google Patents
Immunomodulateurs encapsules utilises comme adjuvants de vaccins Download PDFInfo
- Publication number
- CA2307541A1 CA2307541A1 CA002307541A CA2307541A CA2307541A1 CA 2307541 A1 CA2307541 A1 CA 2307541A1 CA 002307541 A CA002307541 A CA 002307541A CA 2307541 A CA2307541 A CA 2307541A CA 2307541 A1 CA2307541 A1 CA 2307541A1
- Authority
- CA
- Canada
- Prior art keywords
- immunomodulator
- composition
- encapsulated
- vaccine
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2006—IL-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55533—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55538—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne des compositions comprenant un immunomodulateur encapsulé, tel que des cytokines et des lymphokines, qui est utilisé comme adjuvant pour stimuler une réponse immunitaire lorsqu'il est administré à un être humain ou à un animal. Par exemple, une lymphokine telle que l'IL-1.alpha. ou l'IL-1.beta. peut être utilisée comme immunomodulateur encapsulé dans une matrice de la présente invention. La composition encapsulée peut comprendre un antigène de vaccin, tel qu'un virus entier inactivé ou atténué, des peptides recombinés ou synthétiques et d'autres matériaux antigéniques. La matrice d'encapsulation peut être naturelle ou synthétique. La présente invention concerne également l'utilisation, chez un être humain ou un animal, d'un immunomodulateur encapsulé comme adjuvant dans le but de stimuler les réponses immunitaires à un antigène ou à un autre matériau envers lequel on désire provoquer une réponse immunitaire.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96240797A | 1997-10-31 | 1997-10-31 | |
| US08/962,407 | 1997-10-31 | ||
| PCT/US1998/023313 WO1999022763A2 (fr) | 1997-10-31 | 1998-11-02 | Immunomodulateurs encapsules utilises comme adjuvants de vaccins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2307541A1 true CA2307541A1 (fr) | 1999-05-14 |
Family
ID=25505819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002307541A Abandoned CA2307541A1 (fr) | 1997-10-31 | 1998-11-02 | Immunomodulateurs encapsules utilises comme adjuvants de vaccins |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1027071A2 (fr) |
| JP (1) | JP2001521908A (fr) |
| AU (1) | AU1208499A (fr) |
| CA (1) | CA2307541A1 (fr) |
| IL (1) | IL135480A0 (fr) |
| WO (1) | WO1999022763A2 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005220156B2 (en) * | 2004-02-27 | 2011-06-02 | Vaxconsulting | Peptides of IL1 beta and TNF alpha and method of treatment using same |
| EP1928418B1 (fr) | 2005-09-30 | 2011-12-21 | Lipoxen Technologies Limited | Compositions vaccinales liposomales comprenant un antigene polysaccharide et un adjuvant proteique |
| EP3067048B1 (fr) * | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Compositions d'induction des réponses immunitaires |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3002213B2 (ja) * | 1989-11-29 | 2000-01-24 | 帝国臓器製薬株式会社 | ペプチドおよびこのペプチドを含有する薬剤 |
| EP0604727A1 (fr) * | 1992-12-31 | 1994-07-06 | American Cyanamid Company | Immunogénéité améliorée d'un vaccin par incorporation d'un cytocine dans un complexe immunostimulant contenant un antigène |
| US5919480A (en) * | 1996-06-24 | 1999-07-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposomal influenza vaccine composition and method |
-
1998
- 1998-11-02 WO PCT/US1998/023313 patent/WO1999022763A2/fr not_active Ceased
- 1998-11-02 CA CA002307541A patent/CA2307541A1/fr not_active Abandoned
- 1998-11-02 IL IL13548098A patent/IL135480A0/xx not_active IP Right Cessation
- 1998-11-02 AU AU12084/99A patent/AU1208499A/en not_active Abandoned
- 1998-11-02 JP JP2000518694A patent/JP2001521908A/ja active Pending
- 1998-11-02 EP EP98955231A patent/EP1027071A2/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999022763A2 (fr) | 1999-05-14 |
| AU1208499A (en) | 1999-05-24 |
| IL135480A0 (en) | 2001-05-20 |
| JP2001521908A (ja) | 2001-11-13 |
| EP1027071A2 (fr) | 2000-08-16 |
| WO1999022763A3 (fr) | 1999-08-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |