CA2308069A1 - Antagonistes de la gonadoliberine - Google Patents

Antagonistes de la gonadoliberine Download PDF

Info

Publication number
CA2308069A1
CA2308069A1 CA002308069A CA2308069A CA2308069A1 CA 2308069 A1 CA2308069 A1 CA 2308069A1 CA 002308069 A CA002308069 A CA 002308069A CA 2308069 A CA2308069 A CA 2308069A CA 2308069 A1 CA2308069 A1 CA 2308069A1
Authority
CA
Canada
Prior art keywords
substituted
alkyl
aryl
compound
aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002308069A
Other languages
English (en)
Inventor
Lin Chu
Mark T. Goulet
Thomas F. Walsh
Stephanie L. Witkin
Matthew J. Wyvratt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9806694.7A external-priority patent/GB9806694D0/en
Application filed by Individual filed Critical Individual
Publication of CA2308069A1 publication Critical patent/CA2308069A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des composés représentés par la formule générale (I) ainsi que certains de leurs sels pharmaceutiquement admis. Ces produits conviennent comme antagonistes de la gonadolibérine (Gn-RH), et partant, pour le traitement d'une variété d'états en relation notamment avec l'hormone sexuelle, tant chez l'homme que chez la femme.
CA002308069A 1997-10-28 1998-10-23 Antagonistes de la gonadoliberine Abandoned CA2308069A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6331297P 1997-10-28 1997-10-28
US60/063,312 1997-10-28
GBGB9806694.7A GB9806694D0 (en) 1998-03-27 1998-03-27 Antagonists of gonadotropin releasing hormone
GB9806694.7 1998-03-27
PCT/US1998/022487 WO1999021557A1 (fr) 1997-10-28 1998-10-23 Antagonistes de la gonadoliberine

Publications (1)

Publication Number Publication Date
CA2308069A1 true CA2308069A1 (fr) 1999-05-06

Family

ID=26313385

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002308069A Abandoned CA2308069A1 (fr) 1997-10-28 1998-10-23 Antagonistes de la gonadoliberine

Country Status (5)

Country Link
EP (1) EP1049472A4 (fr)
JP (1) JP2001520997A (fr)
AU (1) AU1197299A (fr)
CA (1) CA2308069A1 (fr)
WO (1) WO1999021557A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20000778B1 (en) * 1998-05-15 2004-10-31 Wyeth Corp 2-phenyl-1-/4-(2-aminoethoxy)-benzyl/-indole in combination with estrogens
US6479535B1 (en) 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
GB0017256D0 (en) 2000-07-13 2000-08-30 Merck Sharp & Dohme Therapeutic agents
GB0022670D0 (en) 2000-09-15 2000-11-01 Astrazeneca Ab Molecules
SE0100566D0 (sv) 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
SE0101692D0 (sv) 2001-05-14 2001-05-14 Astrazeneca Ab Compounds
TW200413351A (en) 2002-08-21 2004-08-01 Astrazeneca Ab Chemical compounds
GB0219472D0 (en) 2002-08-21 2002-10-02 Astrazeneca Ab Chemical compounds
ES2298545T3 (es) 2002-08-21 2008-05-16 Astrazeneca Ab Compuestos de tieno-pirrol como antagonistas de la hormona liberadora de gonadotropina.
TW200407127A (en) 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds
US7253290B2 (en) 2002-08-21 2007-08-07 Astrazeneca Ab Pyrazole derivatives as GnRH inhibitors
GB0307777D0 (en) 2003-04-04 2003-05-07 Medical Res Council Conjugate compounds
WO2005118539A1 (fr) 2004-06-01 2005-12-15 F.Hoffmann-La Roche Ag 3-amino-1-arylpropyl indoles utiles comme inhibiteurs de la reabsorption de la monoamine
BRPI0619263A2 (pt) 2005-11-30 2011-09-27 Hoffmann La Roche indóis de 3-amino-1-arilpropila e indóis aza-substituìdos, métodos para prepará-los, composição farmacêutica e uso dos referidos indóis
CA2632284A1 (fr) 2005-11-30 2007-06-07 F. Hoffmann-La Roche Ag 3-amino-2-arylpropyl azaindoles et leurs utilisations
CA2631048A1 (fr) 2005-11-30 2007-06-07 F. Hoffmann-La Roche Ag Procede de synthese de 3-amino-1-arylpropyle indoles
US8378107B2 (en) 2008-10-01 2013-02-19 Panmira Pharmaceuticals, Llc Heteroaryl antagonists of prostaglandin D2 receptors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2181559A1 (en) * 1972-04-28 1973-12-07 Aec Chimie Organique Bio N-Phenylalkyl-N-3-indolylalkyl-alkylamines - with sedative, neuroleptic, analgesic, hypotensive, antiserotonin, adrenolytic activity
IE43725B1 (en) * 1975-10-29 1981-05-06 Lilly Co Eli N-/2-(5-methoxy-6-halo-indol-3-yl)ethyl/-amides,methods for their preparation and their use
DE2933636A1 (de) * 1978-08-30 1980-03-20 Sandoz Ag Neue n-phenylindolinderivate, ihre herstellung und pharmazeutische praeparate, welche diese verbindungen enthalten
US4255432A (en) * 1979-09-06 1981-03-10 Syntex (U.S.A.) Inc. 8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof
US4544663A (en) * 1984-05-07 1985-10-01 Sandoz, Inc. Indolamine derivatives as anti-fertility agents
US5030640A (en) * 1989-01-05 1991-07-09 Merck & Co., Inc. Novel β-adrenergic agonists and pharmaceutical compositions thereof
US5604253A (en) * 1995-05-22 1997-02-18 Merck Frosst Canada, Inc. N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors
SK77298A3 (en) * 1995-12-14 1999-01-11 Merck & Co Inc Nonpeptide derivatives, pharmaceutical composition containing them and their use
US5756507A (en) * 1995-12-14 1998-05-26 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
EE9800181A (et) * 1995-12-14 1998-12-15 Merck & Co., Inc. Gonadotropiini riliisinghormooni antagonist, selle kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod
EP1011667A4 (fr) * 1997-06-05 2001-03-28 Merck & Co Inc Antagonistes de l'hormone de liberation de la gonadotrophine

Also Published As

Publication number Publication date
AU1197299A (en) 1999-05-17
EP1049472A4 (fr) 2002-04-03
JP2001520997A (ja) 2001-11-06
EP1049472A1 (fr) 2000-11-08
WO1999021557A1 (fr) 1999-05-06

Similar Documents

Publication Publication Date Title
CA2292881A1 (fr) Antagonistes de gonadoliberine
EP0871624A1 (fr) Antagonistes de l'hormone de liberaiton de la gonadotropine
CA2291647A1 (fr) Antagonistes de la gonadoliberine
WO1997021435A1 (fr) Antagonistes de la gonadoliberine
US6288078B1 (en) 6-azaindole compounds as antagonists of gonadotropin releasing hormone
CA2292605A1 (fr) Antagonistes de l'hormone de liberation des gonadotrophines
CA2366615A1 (fr) Composes 6-azaindole utilises comme antagonistes d'une hormone liberant la gonadotropine
CA2308454A1 (fr) Antagonistes de l'hormone de liberation de la gonadothrophine
US6156772A (en) Antagonists of gonadotropin releasing hormone
CA2308069A1 (fr) Antagonistes de la gonadoliberine
CA2291829A1 (fr) Antagonistes de l'hormone de liberation de la gonadotrophine
US5981550A (en) Antagonists of gonadotropin releasing hormone
CA2326184A1 (fr) Antagonistes de l'hormone liberant la gonadotropine (gnrh)
US6159989A (en) Antagonists of gonadotropin releasing hormone
CA2367113A1 (fr) Composes 6-azaindole utilises comme antagonistes d'une hormone liberant la gonadotropine
US6180642B1 (en) 6-azaindole compounds as antagonists of Gonadotropin releasing hormone
US6004984A (en) Antagonists of gonadotropin releasing hormone
CA2318957A1 (fr) Antagonistes de l'hormone de liberation de la gonadotrophine
CA2317451A1 (fr) Antagonistes de l'hormone de liberation de la gonadotrophine
CA2367116A1 (fr) Composes 6-azaindole utilises comme antagonistes d'une hormone liberant la gonadotropine
EP1165076A1 (fr) Composes de 6-azaindole comme antagonistes de la gonadoliberine
AU728811B2 (en) Antagonists of gonadotropin releasing hormone
US6211224B1 (en) Antagonists of gonadotropin releasing hormone

Legal Events

Date Code Title Description
FZDE Dead