CA2323151C - Serpentins a base de proteines ou de polymeres biodegradables pour implants intraluminaux - Google Patents

Serpentins a base de proteines ou de polymeres biodegradables pour implants intraluminaux Download PDF

Info

Publication number: CA2323151C
Authority: CA; Canada
Prior art keywords: biocompatible; growth factor; coil; protein; separable
Prior art date: 1999-01-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA002323151A

Other languages

English (en)

Other versions

CA2323151A1 (fr

Inventor

Yuichi Murayama

Fernando Vinuela

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of California San Diego UCSD

Original Assignee

University of California San Diego UCSD

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-27

Filing date

1999-09-27

Publication date

2007-04-10

1999-01-27 Priority claimed from PCT/US1999/001790 external-priority patent/WO1999044538A1/fr

1999-09-27 Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD

2000-08-03 Publication of CA2323151A1 publication Critical patent/CA2323151A1/fr

2007-04-10 Application granted granted Critical

2007-04-10 Publication of CA2323151C publication Critical patent/CA2323151C/fr

2019-09-27 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

102000004169 proteins and genes Human genes 0.000 title claims abstract description 31
108090000623 proteins and genes Proteins 0.000 title claims abstract description 31
239000007943 implant Substances 0.000 title claims description 36
229920002988 biodegradable polymer Polymers 0.000 title description 12
239000004621 biodegradable polymer Substances 0.000 title description 11
229920000642 polymer Polymers 0.000 claims abstract description 43
239000003102 growth factor Substances 0.000 claims abstract description 22
239000000463 material Substances 0.000 claims abstract description 19
102000003974 Fibroblast growth factor 2 Human genes 0.000 claims abstract description 13
108090000379 Fibroblast growth factor 2 Proteins 0.000 claims abstract description 13
108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims abstract description 13
102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims abstract description 13
108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims abstract description 13
201000008450 Intracranial aneurysm Diseases 0.000 claims abstract description 12
229920001432 poly(L-lactide) Polymers 0.000 claims abstract description 12
229920000954 Polyglycolide Polymers 0.000 claims abstract description 11
239000004633 polyglycolic acid Substances 0.000 claims abstract description 11
229920001577 copolymer Polymers 0.000 claims abstract description 8
108010010803 Gelatin Proteins 0.000 claims abstract description 7
229920000159 gelatin Polymers 0.000 claims abstract description 7
235000019322 gelatine Nutrition 0.000 claims abstract description 7
235000011852 gelatine desserts Nutrition 0.000 claims abstract description 7
108010049003 Fibrinogen Proteins 0.000 claims abstract description 6
102000008946 Fibrinogen Human genes 0.000 claims abstract description 6
102100037362 Fibronectin Human genes 0.000 claims abstract description 6
108010067306 Fibronectins Proteins 0.000 claims abstract description 6
102000007547 Laminin Human genes 0.000 claims abstract description 6
108010085895 Laminin Proteins 0.000 claims abstract description 6
229920002732 Polyanhydride Polymers 0.000 claims abstract description 6
229920000331 Polyhydroxybutyrate Polymers 0.000 claims abstract description 6
102100035140 Vitronectin Human genes 0.000 claims abstract description 6
108010031318 Vitronectin Proteins 0.000 claims abstract description 6
229940012952 fibrinogen Drugs 0.000 claims abstract description 6
239000008273 gelatin Substances 0.000 claims abstract description 6
239000005015 poly(hydroxybutyrate) Substances 0.000 claims abstract description 6
229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims abstract description 6
-1 polycaprolactive Polymers 0.000 claims abstract description 6
229920000515 polycarbonate Polymers 0.000 claims abstract description 6
239000004417 polycarbonate Substances 0.000 claims abstract description 6
239000000622 polydioxanone Substances 0.000 claims abstract description 6
230000029663 wound healing Effects 0.000 claims description 11
208000021138 brain aneurysm Diseases 0.000 claims description 5
230000002757 inflammatory effect Effects 0.000 claims description 2
230000004044 response Effects 0.000 claims description 2
206010002329 Aneurysm Diseases 0.000 abstract description 54
230000028709 inflammatory response Effects 0.000 abstract description 13
230000001413 cellular effect Effects 0.000 abstract description 6
108010035532 Collagen Proteins 0.000 abstract description 5
102000008186 Collagen Human genes 0.000 abstract description 5
229920001436 collagen Polymers 0.000 abstract description 5
238000002513 implantation Methods 0.000 abstract description 3
230000002792 vascular Effects 0.000 abstract description 3
230000002885 thrombogenetic effect Effects 0.000 abstract description 2
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 abstract 2
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 18
230000000694 effects Effects 0.000 description 10
208000007536 Thrombosis Diseases 0.000 description 9
229910052697 platinum Inorganic materials 0.000 description 9
210000003739 neck Anatomy 0.000 description 8
238000000034 method Methods 0.000 description 7
229920000249 biocompatible polymer Polymers 0.000 description 6
238000000576 coating method Methods 0.000 description 4
230000035876 healing Effects 0.000 description 4
208000032851 Subarachnoid Hemorrhage Diseases 0.000 description 3
238000005056 compaction Methods 0.000 description 3
239000002131 composite material Substances 0.000 description 3
108010009583 Transforming Growth Factors Proteins 0.000 description 2
102000009618 Transforming Growth Factors Human genes 0.000 description 2
230000001133 acceleration Effects 0.000 description 2
230000008901 benefit Effects 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
239000008280 blood Substances 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
230000017531 blood circulation Effects 0.000 description 2
210000004204 blood vessel Anatomy 0.000 description 2
210000004556 brain Anatomy 0.000 description 2
210000005013 brain tissue Anatomy 0.000 description 2
230000036755 cellular response Effects 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
210000003792 cranial nerve Anatomy 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
238000012377 drug delivery Methods 0.000 description 2
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
230000003902 lesion Effects 0.000 description 2
230000007774 longterm Effects 0.000 description 2
229910052751 metal Inorganic materials 0.000 description 2
239000002184 metal Substances 0.000 description 2
150000002739 metals Chemical class 0.000 description 2
230000001737 promoting effect Effects 0.000 description 2
230000036573 scar formation Effects 0.000 description 2
238000006467 substitution reaction Methods 0.000 description 2
241000282465 Canis Species 0.000 description 1
208000000483 Central Nervous System Vascular Malformations Diseases 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
108090000695 Cytokines Proteins 0.000 description 1
102000004127 Cytokines Human genes 0.000 description 1
229920004934 Dacron® Polymers 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
229920001963 Synthetic biodegradable polymer Polymers 0.000 description 1
108090000190 Thrombin Proteins 0.000 description 1
230000004913 activation Effects 0.000 description 1
230000004075 alteration Effects 0.000 description 1
230000002491 angiogenic effect Effects 0.000 description 1
230000008321 arterial blood flow Effects 0.000 description 1
238000011888 autopsy Methods 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
230000002490 cerebral effect Effects 0.000 description 1
230000004087 circulation Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000005520 electrodynamics Effects 0.000 description 1
238000005868 electrolysis reaction Methods 0.000 description 1
230000003073 embolic effect Effects 0.000 description 1
230000010102 embolization Effects 0.000 description 1
238000012282 endovascular technique Methods 0.000 description 1
239000004744 fabric Substances 0.000 description 1
230000006870 function Effects 0.000 description 1
229910052737 gold Inorganic materials 0.000 description 1
239000010931 gold Substances 0.000 description 1
238000010562 histological examination Methods 0.000 description 1
230000006872 improvement Effects 0.000 description 1
238000007917 intracranial administration Methods 0.000 description 1
230000005923 long-lasting effect Effects 0.000 description 1
238000007726 management method Methods 0.000 description 1
230000005012 migration Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000008692 neointimal formation Effects 0.000 description 1
230000008520 organization Effects 0.000 description 1
210000003101 oviduct Anatomy 0.000 description 1
239000005020 polyethylene terephthalate Substances 0.000 description 1
239000004814 polyurethane Substances 0.000 description 1
229920002635 polyurethane Polymers 0.000 description 1
239000011527 polyurethane coating Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000000541 pulsatile effect Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
241000894007 species Species 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
229910052715 tantalum Inorganic materials 0.000 description 1
GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
229960004072 thrombin Drugs 0.000 description 1
WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
229910052721 tungsten Inorganic materials 0.000 description 1
239000010937 tungsten Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/1215—Coils or wires comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/3008—Properties of materials and coating materials radio-opaque, e.g. radio-opaque markers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
- A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical & Material Sciences (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Surgery (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Medical Informatics (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Rheumatology (AREA)
Oral & Maxillofacial Surgery (AREA)
Transplantation (AREA)
Materials For Medical Uses (AREA)
Surgical Instruments (AREA)
Prostheses (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA002323151A 1999-01-27 1999-09-27 Serpentins a base de proteines ou de polymeres biodegradables pour implants intraluminaux Expired - Lifetime CA2323151C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/US1999/001790 WO1999044538A1 (fr)	1998-01-27	1999-01-27	Serpentins biodegradables a base de polymeres/proteines pour implants endoluminaux
PCT/US1999/022420 WO2000044306A1 (fr)	1999-01-27	1999-09-27	Spirales a base de polymere/proteine biodegradable, pour implants endoluminaux

Publications (2)

Publication Number	Publication Date
CA2323151A1 CA2323151A1 (fr)	2000-08-03
CA2323151C true CA2323151C (fr)	2007-04-10

Family

ID=22272061

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002323151A Expired - Lifetime CA2323151C (fr)	1999-01-27	1999-09-27	Serpentins a base de proteines ou de polymeres biodegradables pour implants intraluminaux

Country Status (5)

Country	Link
EP (1)	EP1156759A4 (fr)
JP (3)	JP2003524456A (fr)
AU (1)	AU6402699A (fr)
CA (1)	CA2323151C (fr)
WO (1)	WO2000044306A1 (fr)

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US7070607B2 (en)	1998-01-27	2006-07-04	The Regents Of The University Of California	Bioabsorbable polymeric implants and a method of using the same to create occlusions
US7018401B1 (en)	1999-02-01	2006-03-28	Board Of Regents, The University Of Texas System	Woven intravascular devices and methods for making the same and apparatus for delivery of the same
US6368346B1 (en)	1999-06-03	2002-04-09	American Medical Systems, Inc.	Bioresorbable stent
US20030004533A1 (en) *	2001-05-04	2003-01-02	Concentric Medical	Bioactive polymer vaso-occlusive device
US6585754B2 (en)	2001-05-29	2003-07-01	Scimed Life Systems, Inc.	Absorbable implantable vaso-occlusive member
EP1411861B1 (fr)	2001-06-29	2012-04-04	Medgraft Microtech, Inc.	Implants injectables biodegradables et procedes de fabrication et d'utilisation associes
US8252040B2 (en)	2001-07-20	2012-08-28	Microvention, Inc.	Aneurysm treatment device and method of use
US7572288B2 (en)	2001-07-20	2009-08-11	Microvention, Inc.	Aneurysm treatment device and method of use
US8715312B2 (en)	2001-07-20	2014-05-06	Microvention, Inc.	Aneurysm treatment device and method of use
EP1793744B1 (fr)	2004-09-22	2008-12-17	Dendron GmbH	Implant medical
US8845676B2 (en)	2004-09-22	2014-09-30	Micro Therapeutics	Micro-spiral implantation device
CA2649702C (fr)	2006-04-17	2014-12-09	Microtherapeutics, Inc.	Systeme et procede destines a positionner mecaniquement des implants intravasculaires
MX344492B (es)	2006-10-22	2016-12-16	Idev Tech Inc *	Dispositivos y métodos para el avance de stent.
CA2934202A1 (fr)	2006-10-22	2008-05-02	Idev Technologies, Inc.	Procedes de fixation d'extremites de brins et dispositifs resultants
JP5249249B2 (ja)	2007-03-13	2013-07-31	コヴィディエンリミテッドパートナーシップ	コイルと耐伸張性部材とが含まれているインプラント
EP2162101B1 (fr)	2007-06-25	2019-02-20	MicroVention, Inc.	Prothèse auto-expansible
US9023095B2 (en)	2010-05-27	2015-05-05	Idev Technologies, Inc.	Stent delivery system with pusher assembly
DE102011007134A1 (de)	2011-04-11	2012-10-11	Basf Se	Verfahren zur Herstellung eines Polyamids durch anionische Polymerisation
CA2835427A1 (fr)	2011-05-11	2012-11-15	Microvention, Inc.	Dispositif permettant d'occlure une lumiere
US9579104B2 (en)	2011-11-30	2017-02-28	Covidien Lp	Positioning and detaching implants
US9011480B2 (en)	2012-01-20	2015-04-21	Covidien Lp	Aneurysm treatment coils
US9687245B2 (en)	2012-03-23	2017-06-27	Covidien Lp	Occlusive devices and methods of use
WO2014165023A1 (fr)	2013-03-12	2014-10-09	Carnegie Mellon University	Dispositif vaso-occlusif enduit pour le traitement d'anévrysmes
US9713475B2 (en)	2014-04-18	2017-07-25	Covidien Lp	Embolic medical devices

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US4994069A (en) *	1988-11-02	1991-02-19	Target Therapeutics	Vaso-occlusion coil and method
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US5853418A (en) *	1995-06-30	1998-12-29	Target Therapeutics, Inc.	Stretch resistant vaso-occlusive coils (II)
ATE197388T1 (de) *	1995-06-30	2000-11-11	Target Therapeutics Inc	Ausdehnungswiderstandsfähige vaso-okklusive spirale
CA2186768C (fr) *	1995-09-29	2000-12-12	Pete Phong Pham	Dispositifs pour occlusion vasculaire, de forme anatomique
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US6007573A (en) *	1996-09-18	1999-12-28	Microtherapeutics, Inc.	Intracranial stent and method of use
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JP4355038B2 (ja) *	1997-09-01	2009-10-28	株式会社カネカメディックス	血管塞栓用具
AU2565099A (en) *	1998-01-27	1999-09-20	Regents Of The University Of California, The	Biodegradable polymer/protein based coils for intralumenal implants
US5935145A (en) *	1998-02-13	1999-08-10	Target Therapeutics, Inc.	Vaso-occlusive device with attached polymeric materials
US6015424A (en) *	1998-04-28	2000-01-18	Microvention, Inc.	Apparatus and method for vascular embolization

1999
- 1999-09-27 JP JP2000595611A patent/JP2003524456A/ja active Pending
- 1999-09-27 CA CA002323151A patent/CA2323151C/fr not_active Expired - Lifetime
- 1999-09-27 WO PCT/US1999/022420 patent/WO2000044306A1/fr not_active Ceased
- 1999-09-27 AU AU64026/99A patent/AU6402699A/en not_active Abandoned
- 1999-09-27 EP EP99951622A patent/EP1156759A4/fr not_active Ceased
2004
- 2004-02-26 JP JP2004051278A patent/JP2004223268A/ja active Pending
2005
- 2005-08-03 JP JP2005225833A patent/JP4751661B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2004223268A (ja)	2004-08-12
EP1156759A4 (fr)	2002-11-20
WO2000044306A1 (fr)	2000-08-03
CA2323151A1 (fr)	2000-08-03
JP4751661B2 (ja)	2011-08-17
EP1156759A1 (fr)	2001-11-28
JP2006021052A (ja)	2006-01-26
AU6402699A (en)	2000-08-18
JP2003524456A (ja)	2003-08-19

Legal Events

Date	Code	Title	Description
2000-09-06	EEER	Examination request
2019-12-01	MKEX	Expiry	Effective date: 20190927

Publication	Publication Date	Title
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ES2391763T3 (es)	2012-11-29	Dispositivo de embolización
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JP2010012282A (ja)	2010-01-21	吸収性移植可能血管閉塞部材
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Krings et al.	2006	Long-term histological and scanning electron microscopy results of endovascular and operative treatments of experimentally induced aneurysms in the rabbit
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JP2004261218A (ja)	2004-09-24	血管塞栓用組成物
EP1543783A1 (fr)	2005-06-22	Dispositif médical implantable activable et biologiquement actif et procédé d'utilisation