CA2325045C - Compositions solides contenant des derives de l'acide gamma-aminobutyrique, et procede de preparation associe - Google Patents

Compositions solides contenant des derives de l'acide gamma-aminobutyrique, et procede de preparation associe Download PDF

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Publication number
CA2325045C
CA2325045C CA002325045A CA2325045A CA2325045C CA 2325045 C CA2325045 C CA 2325045C CA 002325045 A CA002325045 A CA 002325045A CA 2325045 A CA2325045 A CA 2325045A CA 2325045 C CA2325045 C CA 2325045C
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CA
Canada
Prior art keywords
group
amino
humectant
butanoic acid
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002325045A
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English (en)
Other versions
CA2325045A1 (fr
Inventor
Akira Aomatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15097314&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2325045(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Priority claimed from PCT/US1999/010186 external-priority patent/WO1999059572A1/fr
Publication of CA2325045A1 publication Critical patent/CA2325045A1/fr
Application granted granted Critical
Publication of CA2325045C publication Critical patent/CA2325045C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Body Structure For Vehicles (AREA)
  • Arrangement Of Transmissions (AREA)

Abstract

L'invention concerne une composition solide stabilisée contenant un dérivé de l'acide 4-amino-3-substitué-butanoïque, que l'on peut obtenir en incorporant un humectant en tant que stabilisant.
CA002325045A 1998-05-15 1999-05-10 Compositions solides contenant des derives de l'acide gamma-aminobutyrique, et procede de preparation associe Expired - Lifetime CA2325045C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP13312298A JP3761324B2 (ja) 1998-05-15 1998-05-15 乗用田植機
JP10/133112 1998-05-15
PCT/US1999/010186 WO1999059572A1 (fr) 1998-05-15 1999-05-10 Compositions solides contenant des derives de l'acide gamma-aminobutyrique, et procede de preparation associe

Publications (2)

Publication Number Publication Date
CA2325045A1 CA2325045A1 (fr) 1999-11-25
CA2325045C true CA2325045C (fr) 2005-05-03

Family

ID=15097314

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002325045A Expired - Lifetime CA2325045C (fr) 1998-05-15 1999-05-10 Compositions solides contenant des derives de l'acide gamma-aminobutyrique, et procede de preparation associe

Country Status (16)

Country Link
JP (1) JP3761324B2 (fr)
CN (1) CN1171587C (fr)
AT (1) ATE407668T1 (fr)
CA (1) CA2325045C (fr)
CY (1) CY1108488T1 (fr)
DE (1) DE69939532D1 (fr)
DK (1) DK1077691T3 (fr)
EA (1) EA006553B1 (fr)
EE (1) EE05530B1 (fr)
EG (1) EG26287A (fr)
ES (1) ES2312208T3 (fr)
GE (1) GEP20032987B (fr)
IL (2) IL139202A0 (fr)
NZ (1) NZ507162A (fr)
PT (1) PT1077691E (fr)
UA (1) UA76398C2 (fr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4904636B2 (ja) * 2001-05-29 2012-03-28 井関農機株式会社 トラクタフレーム
JP5047022B2 (ja) * 2008-03-24 2012-10-10 ヤンマー株式会社 上下分割式のエンジン収納用パッケージの結合構造
WO2013008182A1 (fr) * 2011-07-10 2013-01-17 Mahesh Kandula Précurseurs d'analogues de l'acide γ-aminobutyrique (gaba)
US9303038B2 (en) 2011-09-06 2016-04-05 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy and neurological diseases
JP2015522531A (ja) 2012-05-07 2015-08-06 セリックスビオ プライヴェート リミテッド 神経筋疾患及び神経変性疾患の治療のための組成物及び方法
WO2013167990A1 (fr) 2012-05-07 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement de la dépression
WO2013168019A1 (fr) * 2012-05-07 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement de la douleur neuropathique
US9738631B2 (en) 2012-05-07 2017-08-22 Cellix Bio Private Limited Compositions and methods for the treatment of neurological disorders
US9266823B2 (en) 2012-05-08 2016-02-23 Cellix Bio Private Limited Compositions and methods for the treatment of parkinson's disease
US9434704B2 (en) 2012-05-08 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of neurological degenerative disorders
US9403826B2 (en) 2012-05-08 2016-08-02 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory disorders
US9309233B2 (en) 2012-05-08 2016-04-12 Cellix Bio Private Limited Compositions and methods for the treatment of blood clotting disorders
US9522884B2 (en) 2012-05-08 2016-12-20 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic disorders
WO2013168004A2 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement de la douleur fibromyalgique
US9315461B2 (en) 2012-05-10 2016-04-19 Cellix Bio Private Limited Compositions and methods for the treatment of neurologic diseases
US9242939B2 (en) 2012-05-10 2016-01-26 Cellix Bio Private Limited Compositions and methods for the treatment of respiratory disorders
WO2013168002A1 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement d'affections neurologiques
US9499526B2 (en) 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of neurologic diseases
US9499527B2 (en) 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of familial amyloid polyneuropathy
SG11201407318UA (en) 2012-05-10 2014-12-30 Cellix Bio Private Ltd Compositions and methods for the treatment of metabolic syndrome
US9321775B2 (en) 2012-05-10 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of moderate to severe pain
US20150087674A1 (en) * 2012-05-10 2015-03-26 Mahesh Kandula Compositions and methods for the treatment of severe pain
US9339484B2 (en) 2012-05-10 2016-05-17 Cellix Bio Private Limited Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
WO2013168011A1 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement de la douleur chronique
WO2013167997A2 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement du syndrome métabolique
WO2013168015A1 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes pour le traitement de l'asthme et de l'allergie
WO2013168000A1 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement de la douleur sévère
US9498461B2 (en) 2012-05-23 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
WO2013175347A2 (fr) 2012-05-23 2013-11-28 Mahesh Kandula Compositions et méthodes pour le traitement de troubles respiratoires
AU2013264820A1 (en) 2012-05-23 2014-11-27 Cellixbio Private Limited Compositions and methods for treatment of mucositis
WO2013175344A2 (fr) 2012-05-23 2013-11-28 Mahesh Kandula Compositions et méthodes pour le traitement de la parodontite et de la polyarthrite rhumatoïde
AU2013264896A1 (en) 2012-05-23 2014-11-27 Cellixbio Private Limited Compositions and methods for the treatment of multiple sclerosis
WO2013175376A2 (fr) 2012-05-23 2013-11-28 Mahesh Kandula Compositions et méthodes de traitement de la douleur locale
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
WO2014020480A2 (fr) 2012-08-03 2014-02-06 Mahesh Kandula Compositions et méthodes pour le traitement de la migraine et de maladies neurologiques
US9624168B2 (en) 2012-09-06 2017-04-18 Cellix Bio Private Limited Compositions and methods for the treatment inflammation and lipid disorders
CA2873029A1 (fr) 2012-09-08 2014-03-13 Cellixbio Private Limited Compositions et methodes de traitement d'une inflammation et de troubles lipidiques
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
SG11201509782TA (en) 2013-06-04 2015-12-30 Cellix Bio Private Ltd Compositions and methods for the treatment of diabetes and pre-diabetes
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
EP3240779B1 (fr) 2014-09-26 2020-10-28 Cellixbio Private Limited Compositions et méthodes de traitement de l'épilepsie et de troubles neurologiques
ES2799309T3 (es) 2014-09-29 2020-12-16 Cellix Bio Private Ltd Compuestos y composiciones para el tratamiento de esclerosis múltiple
CN104352476A (zh) * 2014-10-21 2015-02-18 齐宏 一种加巴喷丁胶囊及其制备方法
CA2965449C (fr) 2014-10-27 2020-11-10 Cellix Bio Private Limited Sels ternaires d'ester monomethylique d'acide fumarique associes a la piperazine ou a l'ethylenediamine pour le traitement de la sclerose en plaques
US10208014B2 (en) 2014-11-05 2019-02-19 Cellix Bio Private Limited Compositions and methods for the treatment of neurological disorders
US9175008B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Prodrugs of anti-platelet agents
US9290486B1 (en) 2014-11-05 2016-03-22 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy
US9321716B1 (en) 2014-11-05 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
US9284287B1 (en) 2014-11-05 2016-03-15 Cellix Bio Private Limited Compositions and methods for the suppression of carbonic anhydrase activity
US9173877B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
US9150557B1 (en) 2014-11-05 2015-10-06 Cellix Bio Private Limited Compositions and methods for the treatment of hyperglycemia
CN107207411A (zh) 2014-12-01 2017-09-26 塞尔利克斯生物私人有限公司 用于治疗多发性硬化的组合物和方法
US9206111B1 (en) 2014-12-17 2015-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
ES2905771T3 (es) 2015-01-06 2022-04-12 Cellix Bio Private Ltd Composiciones y procedimientos para el tratamiento de la inflamación y del dolor

Also Published As

Publication number Publication date
CA2325045A1 (fr) 1999-11-25
CN1171587C (zh) 2004-10-20
EA200001154A1 (ru) 2001-06-25
IL139202A (en) 2014-12-31
JPH11318133A (ja) 1999-11-24
ES2312208T3 (es) 2009-02-16
UA76398C2 (en) 2006-08-15
EA006553B1 (ru) 2006-02-24
DK1077691T3 (da) 2008-10-27
IL139202A0 (en) 2001-11-25
NZ507162A (en) 2003-11-28
DE69939532D1 (de) 2008-10-23
ATE407668T1 (de) 2008-09-15
PT1077691E (pt) 2008-11-04
CY1108488T1 (el) 2014-04-09
CN1300213A (zh) 2001-06-20
GEP20032987B (en) 2003-06-25
EG26287A (en) 2013-06-12
EE05530B1 (et) 2012-04-16
EE200000671A (et) 2002-04-15
JP3761324B2 (ja) 2006-03-29

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Effective date: 20190510