CA2328598A1 - Preparation microbienne de substances a partir de metabolisme iii aromatique - Google Patents

Preparation microbienne de substances a partir de metabolisme iii aromatique Download PDF

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Publication number
CA2328598A1
CA2328598A1 CA002328598A CA2328598A CA2328598A1 CA 2328598 A1 CA2328598 A1 CA 2328598A1 CA 002328598 A CA002328598 A CA 002328598A CA 2328598 A CA2328598 A CA 2328598A CA 2328598 A1 CA2328598 A1 CA 2328598A1
Authority
CA
Canada
Prior art keywords
glucose
gene
activity
enzyme
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002328598A
Other languages
English (en)
Inventor
Marco Kraemer
Martin Karutz
Georg Sprenger
Hermann Sahm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forschungszentrum Juelich GmbH
DSM Verwaltungs GmbH
Holland Sweetener Co VOF
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2328598A1 publication Critical patent/CA2328598A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/222—Phenylalanine

Landscapes

  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne un procédé de préparation microbienne de substances à partir d'un métabolisme aromatique, plus particulièrement d'acides aminés aromatiques. L'invention concerne, en outre, les structures géniques et les cellules transformées. Selon l'invention, on observe une augmentation de la production de substances, notamment d'acides aminés aromatiques, suite à l'introduction ou à l'augmentation de l'activité d'une glucose déhydrogénase. Cette augmentation de l'activité d'une enzyme catalysant l'oxydation du glucose entraîne la formation intracellulaire de gluconolactone et d'acide gluconique à partir de substrats renfermant du glucose. Selon un mode de réalisation préférentiel, la glucose déhydrogénase est dérivée du Bacillus megaterium. Le procédé peut être mis en oeuvre pour fournir une gamme plus variée de substances.
CA002328598A 1998-04-24 1999-04-22 Preparation microbienne de substances a partir de metabolisme iii aromatique Abandoned CA2328598A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19818541.3 1998-04-24
DE19818541A DE19818541C2 (de) 1998-04-24 1998-04-24 Mikrobielle Herstellung von Substanzen aus dem aromatischen Stoffwechsel / III
PCT/NL1999/000232 WO1999055877A1 (fr) 1998-04-24 1999-04-22 Preparation microbienne de substances a partir de metabolisme iii aromatique

Publications (1)

Publication Number Publication Date
CA2328598A1 true CA2328598A1 (fr) 1999-11-04

Family

ID=7865779

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002328598A Abandoned CA2328598A1 (fr) 1998-04-24 1999-04-22 Preparation microbienne de substances a partir de metabolisme iii aromatique

Country Status (8)

Country Link
EP (1) EP1090126A1 (fr)
JP (1) JP2002512802A (fr)
KR (1) KR100567120B1 (fr)
CN (1) CN1289675C (fr)
AU (1) AU3445699A (fr)
CA (1) CA2328598A1 (fr)
DE (1) DE19818541C2 (fr)
WO (1) WO1999055877A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19958159A1 (de) 1999-12-02 2001-06-07 Degussa Neue für das glk-Gen codierende Nukleotidsequenzen
DE10047403A1 (de) * 2000-09-26 2002-04-11 Degussa Neue für das ppgK-Gen kodierende Nukleotidsequenzen
ATE421577T1 (de) 2001-04-04 2009-02-15 Genencor Int Entkoppelte anabole und katabole stoffwechselwege in wirtszellen
CN1298855C (zh) 2001-04-04 2007-02-07 金克克国际有限公司 在宿主细胞中生成产物的方法
KR100433134B1 (ko) * 2002-03-05 2004-05-27 김병기 신규한 호열성 미생물 및 이를 이용한 방향족ｌ-아미노산의 제조 방법
US7572607B2 (en) 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US8372989B2 (en) 2002-04-23 2013-02-12 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
CN1890377B (zh) 2003-10-21 2013-06-05 嘉吉有限公司 生产莫纳甜和莫纳甜前体
RU2004105179A (ru) * 2004-02-25 2005-08-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) 6-фосфоглюконолактоназа из escherichia coli, фрагмент днк, бактерия, принадлежащая к роду escherichia, -продуцент l-аминокислоты, и способ получения l-аминокислоты
BRPI0507978A (pt) * 2004-02-25 2007-07-24 Ajinomoto Kk bactéria produtora de l-aminoácido pertencente à famìlia enterobacteriaceae, e, método para produzir um l-aminoácido
US8158389B2 (en) 2005-04-20 2012-04-17 Cargill, Incorporated Products and methods for in vivo secretion of monatin
WO2006113897A2 (fr) 2005-04-20 2006-10-26 Cargill, Incorporated Produits et procedes de secretion de monatine in vivo
US7582455B2 (en) 2005-04-26 2009-09-01 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
US8076108B2 (en) 2005-04-26 2011-12-13 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
KR101324369B1 (ko) 2008-11-05 2013-11-01 미쓰이 가가쿠 가부시키가이샤 2-디옥시-실로-이노소스（ｄｏｉ） 생산 세균 및 이를 이용한 2-디옥시-실로-이노소스（ｄｏｉ） 생산 방법
KR102105532B1 (ko) * 2013-10-17 2020-04-29 (주)아모레퍼시픽 만능 줄기세포의 유도 방법 및 상기 방법에 의해 제조된 만능줄기세포
KR102134418B1 (ko) * 2019-06-17 2020-07-16 씨제이제일제당 주식회사 L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법
CN120536329B (zh) * 2025-05-20 2026-01-06 湖北大学 一种生产黑色素的运动发酵单胞菌重组菌株构建方法及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3711881A1 (de) * 1987-04-08 1988-10-27 Merck Patent Gmbh Verfahren zur herstellung von glucosedehydrogenase aus bacillus megaterium
US5032514A (en) * 1988-08-08 1991-07-16 Genentech, Inc. Metabolic pathway engineering to increase production of ascorbic acid intermediates
JPH0286779A (ja) * 1988-09-22 1990-03-27 Amano Pharmaceut Co Ltd 改良型組換えｄｎａ、それを含む形質転換体及びそれを用いた耐熱性グルコースデヒドロゲナーゼの製造法
US5437083A (en) 1993-05-24 1995-08-01 Advanced Cardiovascular Systems, Inc. Stent-loading mechanism

Also Published As

Publication number Publication date
EP1090126A1 (fr) 2001-04-11
KR20010042974A (ko) 2001-05-25
AU3445699A (en) 1999-11-16
WO1999055877A1 (fr) 1999-11-04
DE19818541C2 (de) 2003-04-10
CN1289675C (zh) 2006-12-13
KR100567120B1 (ko) 2006-03-31
JP2002512802A (ja) 2002-05-08
CN1298448A (zh) 2001-06-06
DE19818541A1 (de) 1999-11-11

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