CA2331370A1 - Compositions a base d'oligomeres proteiniques renfermant la proteine endostatine et procedes d'utilisation - Google Patents
Compositions a base d'oligomeres proteiniques renfermant la proteine endostatine et procedes d'utilisation Download PDFInfo
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- CA2331370A1 CA2331370A1 CA002331370A CA2331370A CA2331370A1 CA 2331370 A1 CA2331370 A1 CA 2331370A1 CA 002331370 A CA002331370 A CA 002331370A CA 2331370 A CA2331370 A CA 2331370A CA 2331370 A1 CA2331370 A1 CA 2331370A1
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- endostatin
- oligomer
- protein
- zinc
- oligomers
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention concerne des compositions à base d'oligomères protéiniques renfermant la protéine endostatine, ainsi que des procédés relatifs à l'utilisation desdites compositions, pour interrompre la formation de tubules et inhiber la tumorigenèse. Ces compositions représentent une nouvelle classe de facteurs de dispersion et comprennent spécifiquement les dimères et les trimères de la protéine endostatine, s'étendant éventuellement à des ions métalliques du type zinc.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8789098P | 1998-06-03 | 1998-06-03 | |
| US60/087,890 | 1998-06-03 | ||
| US9239398P | 1998-07-10 | 1998-07-10 | |
| US60/092,393 | 1998-07-10 | ||
| US9879098P | 1998-09-01 | 1998-09-01 | |
| US60/7098,790 | 1998-09-01 | ||
| PCT/US1999/012278 WO1999062944A2 (fr) | 1998-06-03 | 1999-06-03 | Compositions a base d'oligomeres proteiniques renfermant la proteine endostatine et procedes d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2331370A1 true CA2331370A1 (fr) | 1999-12-09 |
Family
ID=27375776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002331370A Abandoned CA2331370A1 (fr) | 1998-06-03 | 1999-06-03 | Compositions a base d'oligomeres proteiniques renfermant la proteine endostatine et procedes d'utilisation |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP2002517186A (fr) |
| KR (1) | KR20010052566A (fr) |
| AU (1) | AU4414099A (fr) |
| CA (1) | CA2331370A1 (fr) |
| WO (1) | WO1999062944A2 (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6440729B1 (en) | 1995-06-30 | 2002-08-27 | University Of Kansas Medical Center | Treating angiogenesis-mediated diseases with the α2 monomer of type IV collagen |
| US6358735B1 (en) | 1995-06-30 | 2002-03-19 | University Of Kansas Medical Center | Method for inhibiting angiogenesis and tumors with the isolated NC1 α3 chain monomer of type IV collagen |
| ES2590912T3 (es) | 1997-12-08 | 2016-11-24 | Merck Patent Gmbh | Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario |
| AU761027B2 (en) * | 1998-08-25 | 2003-05-29 | Merck Patent Gmbh | Expression and export of angiostatin and endostatin as immunofusis |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| MXPA02001417A (es) | 1999-08-09 | 2002-08-12 | Lexigen Pharm Corp | Complejos multiples de citosina-anticuerpo. |
| CA2391080A1 (fr) | 1999-11-12 | 2001-05-25 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Formes d'erythropoietine dotees de proprietes ameliorees |
| HUP0204475A2 (en) | 2000-02-11 | 2003-04-28 | Merck Patent Gmbh | Enhancing the circulating half-life of antibody-based fusion proteins |
| KR20030064275A (ko) | 2000-06-29 | 2003-07-31 | 메르크 파텐트 게엠베하 | 면역싸이토카인 흡수 증강제와의 조합 치료에 의한항체-싸이토카인 융합 단백질 매개 면역 반응 증강 |
| RU2003129528A (ru) | 2001-03-07 | 2005-04-10 | Мерк Патент ГмбХ (DE) | Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела |
| WO2002079415A2 (fr) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reduction de l'immunogenicite de proteines de fusion |
| EP1383785B1 (fr) | 2001-05-03 | 2011-03-16 | Merck Patent GmbH | Anticorps recombine a specificite tumorale et utilisation correspondante |
| DK1454138T3 (da) | 2001-12-04 | 2012-02-13 | Merck Patent Gmbh | Immunocytokiner med moduleret selektivitet |
| WO2004055056A1 (fr) | 2002-12-17 | 2004-07-01 | Merck Patent Gmbh | Forme humanisee de l'anticorps de souris 14.18 (h14.18) se liant au gd2 et fusion de celle-ci avec il-2 |
| DE602004015142D1 (de) * | 2003-08-29 | 2008-08-28 | Childrens Medical Center | Antiangiogene peptide zur behandlung oder vorbeugung von endometriose |
| US7524811B2 (en) | 2003-08-29 | 2009-04-28 | Children's Medical Center Corporation | Anti-angiogenic peptides from the N-terminus of endostatin |
| FR2898895B1 (fr) * | 2006-03-23 | 2012-04-06 | Univ Reims Champagne Ardenne | Cyclopeptide a activite anti-cancereuse derive du collagene de type iv |
| BRPI0605212B8 (pt) * | 2006-12-12 | 2021-05-25 | Univ Rio De Janeiro | processo de produção de endostatina dimerizada ou oligomerizada, endostatina dimerizada ou oligomerizada e composição farmacêutica |
| EP2270055A4 (fr) | 2008-04-04 | 2011-06-29 | Procell Therapeutics Inc | Protéine recombinante d'endostatine à cellules perméables |
| EP2561888A1 (fr) * | 2011-08-23 | 2013-02-27 | Deutsches Krebsforschungszentrum | Protéine comprenant NC-1 pour traiter des maladies liées à l'angiogenèse |
| MX2016003617A (es) * | 2013-09-30 | 2016-07-21 | Chugai Pharmaceutical Co Ltd | Metodo para producir molecula de enlace al antigeno usando fago auxiliar modificado. |
| CN115925878A (zh) * | 2015-06-05 | 2023-04-07 | 艾比欧公司 | 用于治疗纤维化的内皮抑素片段和变体 |
| CN112236448B (zh) | 2018-04-17 | 2025-02-11 | 海德堡生物技术有限公司 | 用包含NC-1-Fc的蛋白寡聚体治疗血管发生、纤维化和癌症相关疾病的手段和方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3840262B2 (ja) * | 1995-10-23 | 2006-11-01 | ザ チルドレンズ メディカル センター コーポレイション | 治療用の抗血管新生組成物および方法 |
-
1999
- 1999-06-03 CA CA002331370A patent/CA2331370A1/fr not_active Abandoned
- 1999-06-03 KR KR1020007013734A patent/KR20010052566A/ko not_active Ceased
- 1999-06-03 WO PCT/US1999/012278 patent/WO1999062944A2/fr not_active Ceased
- 1999-06-03 AU AU44140/99A patent/AU4414099A/en not_active Abandoned
- 1999-06-03 JP JP2000552154A patent/JP2002517186A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999062944A2 (fr) | 1999-12-09 |
| AU4414099A (en) | 1999-12-20 |
| JP2002517186A (ja) | 2002-06-18 |
| WO1999062944A3 (fr) | 2000-04-06 |
| KR20010052566A (ko) | 2001-06-25 |
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