CA2336848A1 - Nouveaux inhibiteurs de l'angiogenese - Google Patents

Nouveaux inhibiteurs de l'angiogenese Download PDF

Info

Publication number
CA2336848A1
CA2336848A1 CA002336848A CA2336848A CA2336848A1 CA 2336848 A1 CA2336848 A1 CA 2336848A1 CA 002336848 A CA002336848 A CA 002336848A CA 2336848 A CA2336848 A CA 2336848A CA 2336848 A1 CA2336848 A1 CA 2336848A1
Authority
CA
Canada
Prior art keywords
phenyl
hydroxy
acetamidooxazole
valeramidooxazole
benzamidooxazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002336848A
Other languages
English (en)
Inventor
Mark E. Fraley
Randall W. Hungate
William F. Hoffman
William R. Huckle
Richard L. Kendall
Kenneth A. Thomas, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9822700.2A external-priority patent/GB9822700D0/en
Application filed by Individual filed Critical Individual
Publication of CA2336848A1 publication Critical patent/CA2336848A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des composés inhibant l'enzyme tyrosine kinase, des compositions contenant ces composés inhibant la tyrosine kinase, ainsi que des procédés d'utilisation de ces inhibiteurs pour traiter des maladies et états associés à la tyrosine kinase, tels que l'angiogenèse, le cancer, l'athérosclérose, la rétinopathie diabétique ou les maladies auto-immunes, chez des mammifères.
CA002336848A 1998-07-10 1999-07-06 Nouveaux inhibiteurs de l'angiogenese Abandoned CA2336848A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9228598P 1998-07-10 1998-07-10
US60/092,285 1998-07-10
GB9822700.2 1998-10-16
GBGB9822700.2A GB9822700D0 (en) 1998-10-16 1998-10-16 Novel angiogenesis inhibitors
PCT/US1999/015200 WO2000002871A1 (fr) 1998-07-10 1999-07-06 Nouveaux inhibiteurs de l'angiogenese

Publications (1)

Publication Number Publication Date
CA2336848A1 true CA2336848A1 (fr) 2000-01-20

Family

ID=26314531

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002336848A Abandoned CA2336848A1 (fr) 1998-07-10 1999-07-06 Nouveaux inhibiteurs de l'angiogenese

Country Status (5)

Country Link
EP (1) EP1097147A4 (fr)
JP (1) JP2002520324A (fr)
AU (1) AU747427B2 (fr)
CA (1) CA2336848A1 (fr)
WO (1) WO2000002871A1 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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WO2002050071A1 (fr) 2000-12-21 2002-06-27 Bristol-Myers Squibb Company Inhibiteurs thiazolyl des tyrosine kinases de la famille tec
US7081454B2 (en) 2001-03-28 2006-07-25 Bristol-Myers Squibb Co. Tyrosine kinase inhibitors
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US8030336B2 (en) * 2002-12-13 2011-10-04 Ym Biosciences Australia Pty Ltd Nicotinamide-based kinase inhibitors
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US7312215B2 (en) 2003-07-29 2007-12-25 Bristol-Myers Squibb Company Benzimidazole C-2 heterocycles as kinase inhibitors
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US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
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Also Published As

Publication number Publication date
JP2002520324A (ja) 2002-07-09
AU5208299A (en) 2000-02-01
EP1097147A1 (fr) 2001-05-09
AU747427B2 (en) 2002-05-16
EP1097147A4 (fr) 2001-11-21
WO2000002871A1 (fr) 2000-01-20

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