CA2342072C - Polypeptide zkun6 du domaine de kunitz - Google Patents
Polypeptide zkun6 du domaine de kunitz Download PDFInfo
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- CA2342072C CA2342072C CA002342072A CA2342072A CA2342072C CA 2342072 C CA2342072 C CA 2342072C CA 002342072 A CA002342072 A CA 002342072A CA 2342072 A CA2342072 A CA 2342072A CA 2342072 C CA2342072 C CA 2342072C
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
L'invention concerne des inhibiteurs de protéinase comportant un domaine de Kunitz. Le domaine de Kunitz comporte une séquence de résidus d'acides aminés présentée dans SEQ ID NO:3, la séquence étant à 80 % au moins identique aux résidus 6 à 56 de SEQ ID NO:2. L'invention concerne également des procédés de fabrication des inhibiteurs de protéinase, et des vecteurs d'expression et des cellules cultivées qui sont utiles dans les procédés. Les inhibiteurs de protéinase peuvent être utilisés comme constituants de milieux de culture cellulaire, dans la purification de protéines et dans certaines applications thérapeutiques et diagnostiques.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14809298A | 1998-09-03 | 1998-09-03 | |
| US09/148,092 | 1998-09-03 | ||
| PCT/US1999/020202 WO2000014235A1 (fr) | 1998-09-03 | 1999-09-01 | Polypeptide zkun6 du domaine de kunitz |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2342072A1 CA2342072A1 (fr) | 2000-03-16 |
| CA2342072C true CA2342072C (fr) | 2005-01-11 |
Family
ID=22524234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002342072A Expired - Fee Related CA2342072C (fr) | 1998-09-03 | 1999-09-01 | Polypeptide zkun6 du domaine de kunitz |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1108029A1 (fr) |
| JP (1) | JP2002524076A (fr) |
| AU (1) | AU5805499A (fr) |
| CA (1) | CA2342072C (fr) |
| IL (1) | IL141644A0 (fr) |
| WO (1) | WO2000014235A1 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| WO2003103475A2 (fr) | 2002-06-07 | 2003-12-18 | Dyax Corp. | Prevention et reduction de la perte sanguine |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| JP2005537006A (ja) | 2002-08-28 | 2005-12-08 | ダイアックス、コープ | 臓器及び組織の保存方法 |
| AU2012216529B2 (en) * | 2002-08-28 | 2014-12-11 | Takeda Pharmaceutical Company Limited | Methods for preserving organs and tissues |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| JPWO2009101737A1 (ja) * | 2008-02-14 | 2011-06-02 | 国立大学法人大阪大学 | メチオニン残基含有ペプチドタグ付きタンパク質発現ベクター |
| CA2744235A1 (fr) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Traitement de la mucosite par des inhibiteurs de kallikreine |
| EP3459564B1 (fr) | 2010-01-06 | 2021-10-27 | Takeda Pharmaceutical Company Limited | Protéines de liaison de kallicréine plasmatique |
| CA2823776A1 (fr) | 2011-01-06 | 2012-07-12 | Dyax Corp. | Proteines se liant a la kallikreine plasmatique |
| AU2016366557B2 (en) | 2015-12-11 | 2024-01-25 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
| US12528880B2 (en) | 2020-01-13 | 2026-01-20 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2229236T3 (es) * | 1994-01-11 | 2005-04-16 | Dyax Corporation | Inhibidores de la plasmina humana derivados de los dominios de kunitz. |
-
1999
- 1999-09-01 IL IL14164499A patent/IL141644A0/xx unknown
- 1999-09-01 JP JP2000568978A patent/JP2002524076A/ja active Pending
- 1999-09-01 AU AU58054/99A patent/AU5805499A/en not_active Abandoned
- 1999-09-01 CA CA002342072A patent/CA2342072C/fr not_active Expired - Fee Related
- 1999-09-01 WO PCT/US1999/020202 patent/WO2000014235A1/fr not_active Ceased
- 1999-09-01 EP EP99945458A patent/EP1108029A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU5805499A (en) | 2000-03-27 |
| IL141644A0 (en) | 2002-03-10 |
| JP2002524076A (ja) | 2002-08-06 |
| CA2342072A1 (fr) | 2000-03-16 |
| WO2000014235A1 (fr) | 2000-03-16 |
| EP1108029A1 (fr) | 2001-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |