CA2348495C - Lentilles intraoculaires de compositions polymeriques - Google Patents

Lentilles intraoculaires de compositions polymeriques Download PDF

Info

Publication number: CA2348495C
Authority: CA; Canada
Prior art keywords: cross; linked polymeric; polymeric material; monomeric component; ophthalmic lens
Prior art date: 1998-10-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA002348495A

Other languages

English (en)

Other versions

CA2348495A1 (fr

Inventor

Harish C. Makker

Xiugao Liao

Joseph I. Weinschenk, Iii

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Johnson and Johnson Surgical Vision Inc

Original Assignee

Advanced Medical Optics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-29

Filing date

1999-10-25

Publication date

2008-07-15

1999-03-09 Priority claimed from US09/265,720 external-priority patent/US6241766B1/en

1999-04-05 Priority claimed from US09/286,356 external-priority patent/US6245106B1/en

1999-10-25 Application filed by Advanced Medical Optics Inc filed Critical Advanced Medical Optics Inc

2000-05-11 Publication of CA2348495A1 publication Critical patent/CA2348495A1/fr

2008-07-15 Application granted granted Critical

2008-07-15 Publication of CA2348495C publication Critical patent/CA2348495C/fr

2019-10-25 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 44
239000000463 material Substances 0.000 claims abstract description 118
125000000217 alkyl group Chemical group 0.000 claims abstract description 42
239000000470 constituent Substances 0.000 claims abstract description 38
150000001252 acrylic acid derivatives Chemical class 0.000 claims abstract description 18
150000002734 metacrylic acid derivatives Chemical class 0.000 claims abstract description 18
239000004971 Cross linker Substances 0.000 claims abstract description 6
229920001519 homopolymer Polymers 0.000 claims description 17
238000003780 insertion Methods 0.000 claims description 13
230000037431 insertion Effects 0.000 claims description 13
-1 phenoxy alkyl methacrylates Chemical class 0.000 claims description 12
125000003118 aryl group Chemical group 0.000 claims description 9
125000004432 carbon atom Chemical group C* 0.000 claims description 5
230000009477 glass transition Effects 0.000 claims description 5
APAUNQLFVGBQQW-UHFFFAOYSA-N (1,2,2-trimethylcyclohexyl) 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC1(C)CCCCC1(C)C APAUNQLFVGBQQW-UHFFFAOYSA-N 0.000 claims description 3
CLHPBURJMZXHFZ-UHFFFAOYSA-N (1,2,2-trimethylcyclohexyl) prop-2-enoate Chemical compound CC1(C)CCCCC1(C)OC(=O)C=C CLHPBURJMZXHFZ-UHFFFAOYSA-N 0.000 claims description 3
OOHZIRUJZFRULE-UHFFFAOYSA-N 2,2-dimethylpropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(C)(C)C OOHZIRUJZFRULE-UHFFFAOYSA-N 0.000 claims description 3
IJLJDZOLZATUFK-UHFFFAOYSA-N 2,2-dimethylpropyl prop-2-enoate Chemical compound CC(C)(C)COC(=O)C=C IJLJDZOLZATUFK-UHFFFAOYSA-N 0.000 claims description 3
WDQMWEYDKDCEHT-UHFFFAOYSA-N 2-ethylhexyl 2-methylprop-2-enoate Chemical compound CCCCC(CC)COC(=O)C(C)=C WDQMWEYDKDCEHT-UHFFFAOYSA-N 0.000 claims description 3
RUMACXVDVNRZJZ-UHFFFAOYSA-N 2-methylpropyl 2-methylprop-2-enoate Chemical compound CC(C)COC(=O)C(C)=C RUMACXVDVNRZJZ-UHFFFAOYSA-N 0.000 claims description 3
CFVWNXQPGQOHRJ-UHFFFAOYSA-N 2-methylpropyl prop-2-enoate Chemical compound CC(C)COC(=O)C=C CFVWNXQPGQOHRJ-UHFFFAOYSA-N 0.000 claims description 3
ULYIFEQRRINMJQ-UHFFFAOYSA-N 3-methylbutyl 2-methylprop-2-enoate Chemical compound CC(C)CCOC(=O)C(C)=C ULYIFEQRRINMJQ-UHFFFAOYSA-N 0.000 claims description 3
ZVYGIPWYVVJFRW-UHFFFAOYSA-N 3-methylbutyl prop-2-enoate Chemical compound CC(C)CCOC(=O)C=C ZVYGIPWYVVJFRW-UHFFFAOYSA-N 0.000 claims description 3
DQUWHUGMYSBESS-UHFFFAOYSA-N 1,1'-biphenyl;2-methylprop-2-enoic acid Chemical class CC(=C)C(O)=O.C1=CC=CC=C1C1=CC=CC=C1 DQUWHUGMYSBESS-UHFFFAOYSA-N 0.000 claims description 2
QJYBLGMKMPXOEI-UHFFFAOYSA-N 1,1'-biphenyl;prop-2-enoic acid Chemical class OC(=O)C=C.C1=CC=CC=C1C1=CC=CC=C1 QJYBLGMKMPXOEI-UHFFFAOYSA-N 0.000 claims description 2
LTHJXDSHSVNJKG-UHFFFAOYSA-N 2-[2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOCCOC(=O)C(C)=C LTHJXDSHSVNJKG-UHFFFAOYSA-N 0.000 claims description 2
KSXOJSNIDZMWPM-UHFFFAOYSA-N 9h-carbazole;2-methylprop-2-enoic acid Chemical class CC(=C)C(O)=O.C1=CC=C2C3=CC=CC=C3NC2=C1 KSXOJSNIDZMWPM-UHFFFAOYSA-N 0.000 claims description 2
RWMLHXXJCLCEMR-UHFFFAOYSA-N 9h-carbazole;prop-2-enoic acid Chemical class OC(=O)C=C.C1=CC=C2C3=CC=CC=C3NC2=C1 RWMLHXXJCLCEMR-UHFFFAOYSA-N 0.000 claims description 2
AOJOEFVRHOZDFN-UHFFFAOYSA-N benzyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC1=CC=CC=C1 AOJOEFVRHOZDFN-UHFFFAOYSA-N 0.000 claims description 2
GCTPMLUUWLLESL-UHFFFAOYSA-N benzyl prop-2-enoate Chemical compound C=CC(=O)OCC1=CC=CC=C1 GCTPMLUUWLLESL-UHFFFAOYSA-N 0.000 claims description 2
239000007943 implant Substances 0.000 claims description 2
QIWKUEJZZCOPFV-UHFFFAOYSA-N phenyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC1=CC=CC=C1 QIWKUEJZZCOPFV-UHFFFAOYSA-N 0.000 claims description 2
WRAQQYDMVSCOTE-UHFFFAOYSA-N phenyl prop-2-enoate Chemical compound C=CC(=O)OC1=CC=CC=C1 WRAQQYDMVSCOTE-UHFFFAOYSA-N 0.000 claims description 2
FBCQUCJYYPMKRO-UHFFFAOYSA-N prop-2-enyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC=C FBCQUCJYYPMKRO-UHFFFAOYSA-N 0.000 claims description 2
QTECDUFMBMSHKR-UHFFFAOYSA-N prop-2-enyl prop-2-enoate Chemical compound C=CCOC(=O)C=C QTECDUFMBMSHKR-UHFFFAOYSA-N 0.000 claims description 2
GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 claims 2
125000001153 fluoro group Chemical group F* 0.000 claims 2
125000005359 phenoxyalkyl group Chemical group 0.000 claims 1
229920001577 copolymer Polymers 0.000 description 32
230000003287 optical effect Effects 0.000 description 13
230000002829 reductive effect Effects 0.000 description 13
239000000178 monomer Substances 0.000 description 9
238000000034 method Methods 0.000 description 8
239000003999 initiator Substances 0.000 description 7
238000006116 polymerization reaction Methods 0.000 description 7
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
239000003054 catalyst Substances 0.000 description 4
238000004132 cross linking Methods 0.000 description 4
238000002513 implantation Methods 0.000 description 4
239000007788 liquid Substances 0.000 description 4
FIXKCCRANLATRP-UHFFFAOYSA-N 3,5,5-trimethylhexyl prop-2-enoate Chemical compound CC(C)(C)CC(C)CCOC(=O)C=C FIXKCCRANLATRP-UHFFFAOYSA-N 0.000 description 3
NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 3
238000010276 construction Methods 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
238000009832 plasma treatment Methods 0.000 description 3
229920000642 polymer Polymers 0.000 description 3
DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 2
208000002847 Surgical Wound Diseases 0.000 description 2
NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
238000004873 anchoring Methods 0.000 description 2
229910052799 carbon Inorganic materials 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 2
ZYMKZMDQUPCXRP-UHFFFAOYSA-N fluoro prop-2-enoate Chemical compound FOC(=O)C=C ZYMKZMDQUPCXRP-UHFFFAOYSA-N 0.000 description 2
125000000524 functional group Chemical group 0.000 description 2
230000035876 healing Effects 0.000 description 2
238000001746 injection moulding Methods 0.000 description 2
229910052751 metal Inorganic materials 0.000 description 2
239000002184 metal Substances 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
229920000058 polyacrylate Polymers 0.000 description 2
239000004926 polymethyl methacrylate Substances 0.000 description 2
238000011417 postcuring Methods 0.000 description 2
125000001424 substituent group Chemical group 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
AVTLBBWTUPQRAY-UHFFFAOYSA-N 2-(2-cyanobutan-2-yldiazenyl)-2-methylbutanenitrile Chemical compound CCC(C)(C#N)N=NC(C)(CC)C#N AVTLBBWTUPQRAY-UHFFFAOYSA-N 0.000 description 1
OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 1
DTCZVVFWWHAXJK-UHFFFAOYSA-N 2-(4-benzoyl-4-hydroxycyclohexa-1,5-dien-1-yl)oxyethyl prop-2-enoate Chemical compound C=1C=CC=CC=1C(=O)C1(O)CC=C(OCCOC(=O)C=C)C=C1 DTCZVVFWWHAXJK-UHFFFAOYSA-N 0.000 description 1
WYGWHHGCAGTUCH-UHFFFAOYSA-N 2-[(2-cyano-4-methylpentan-2-yl)diazenyl]-2,4-dimethylpentanenitrile Chemical compound CC(C)CC(C)(C#N)N=NC(C)(C#N)CC(C)C WYGWHHGCAGTUCH-UHFFFAOYSA-N 0.000 description 1
CEXQWAAGPPNOQF-UHFFFAOYSA-N 2-phenoxyethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOC1=CC=CC=C1 CEXQWAAGPPNOQF-UHFFFAOYSA-N 0.000 description 1
RZVINYQDSSQUKO-UHFFFAOYSA-N 2-phenoxyethyl prop-2-enoate Chemical compound C=CC(=O)OCCOC1=CC=CC=C1 RZVINYQDSSQUKO-UHFFFAOYSA-N 0.000 description 1
239000004342 Benzoyl peroxide Substances 0.000 description 1
OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
239000004952 Polyamide Substances 0.000 description 1
239000004642 Polyimide Substances 0.000 description 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
JUIBLDFFVYKUAC-UHFFFAOYSA-N [5-(2-ethylhexanoylperoxy)-2,5-dimethylhexan-2-yl] 2-ethylhexaneperoxoate Chemical compound CCCCC(CC)C(=O)OOC(C)(C)CCC(C)(C)OOC(=O)C(CC)CCCC JUIBLDFFVYKUAC-UHFFFAOYSA-N 0.000 description 1
230000002411 adverse Effects 0.000 description 1
239000000956 alloy Substances 0.000 description 1
229910045601 alloy Inorganic materials 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
150000008366 benzophenones Chemical class 0.000 description 1
QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 1
239000012964 benzotriazole Substances 0.000 description 1
235000019400 benzoyl peroxide Nutrition 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
150000001721 carbon Chemical group 0.000 description 1
238000005266 casting Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000005336 cracking Methods 0.000 description 1
229920006037 cross link polymer Polymers 0.000 description 1
238000005520 cutting process Methods 0.000 description 1
125000000753 cycloalkyl group Chemical group 0.000 description 1
230000002542 deteriorative effect Effects 0.000 description 1
230000001627 detrimental effect Effects 0.000 description 1
238000001125 extrusion Methods 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
208000014674 injury Diseases 0.000 description 1
230000002452 interceptive effect Effects 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
230000007774 longterm Effects 0.000 description 1
238000003754 machining Methods 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
238000003801 milling Methods 0.000 description 1
MDYPDLBFDATSCF-UHFFFAOYSA-N nonyl prop-2-enoate Chemical compound CCCCCCCCCOC(=O)C=C MDYPDLBFDATSCF-UHFFFAOYSA-N 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920001721 polyimide Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
229920001343 polytetrafluoroethylene Polymers 0.000 description 1
239000004810 polytetrafluoroethylene Substances 0.000 description 1
229920002981 polyvinylidene fluoride Polymers 0.000 description 1
230000002980 postoperative effect Effects 0.000 description 1
239000002243 precursor Substances 0.000 description 1
150000003254 radicals Chemical class 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
239000010703 silicon Substances 0.000 description 1
229920005573 silicon-containing polymer Polymers 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
229910052715 tantalum Inorganic materials 0.000 description 1
GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
229920001169 thermoplastic Polymers 0.000 description 1
229910052719 titanium Inorganic materials 0.000 description 1
239000010936 titanium Substances 0.000 description 1
230000008733 trauma Effects 0.000 description 1

Classifications

- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Optics & Photonics (AREA)
Dermatology (AREA)
Medicinal Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Transplantation (AREA)
General Physics & Mathematics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Materials For Medical Uses (AREA)
Prostheses (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Eyeglasses (AREA)

CA002348495A 1998-10-29 1999-10-25 Lentilles intraoculaires de compositions polymeriques Expired - Lifetime CA2348495C (fr)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
US10638198P	1998-10-29	1998-10-29
US09/265,720 US6241766B1 (en)	1998-10-29	1999-03-09	Intraocular lenses made from polymeric compositions
US09/265,720		1999-04-05
US60/106,381		1999-04-05
US09/286,356		1999-04-05
US09/286,356 US6245106B1 (en)	1998-10-29	1999-04-05	Intraocular lenses made from polymeric compositions and monomers useful in said compositions
PCT/US1999/024982 WO2000026698A1 (fr)	1998-10-29	1999-10-25	Cristallins artificiels fabriques a partir de compositions polymeres

Publications (2)

Publication Number	Publication Date
CA2348495A1 CA2348495A1 (fr)	2000-05-11
CA2348495C true CA2348495C (fr)	2008-07-15

Family

ID=27380106

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002348495A Expired - Lifetime CA2348495C (fr)	1998-10-29	1999-10-25	Lentilles intraoculaires de compositions polymeriques

Country Status (6)

Country	Link
EP (1)	EP1137956A1 (fr)
JP (2)	JP2002529759A (fr)
AU (1)	AU760960B2 (fr)
BR (1)	BR9914904A (fr)
CA (1)	CA2348495C (fr)
WO (1)	WO2000026698A1 (fr)

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Publication number	Priority date	Publication date	Assignee	Title
US6491721B2 (en)	1998-04-15	2002-12-10	Alcon Manufacturing, Ltd.	Toric intraocular lens material
US6416550B2 (en)	1998-04-15	2002-07-09	Alcon Manufacturing, Ltd.	Method of selecting an intraocular lens material
US6271281B1 (en)	1999-08-26	2001-08-07	Medennium, Inc.	Homopolymers containing stable elasticity inducing crosslinkers and ocular implants made therefrom
ATE291045T1 (de)	1999-09-07	2005-04-15	Alcon Inc	Material für faltbare ophtalmische und otorhinolaryngologische gegenstände
US6679605B2 (en) *	2000-05-22	2004-01-20	Medennium, Inc.	Crystalline polymeric compositions for ophthalmic devices
US7173073B2 (en)	2002-01-14	2007-02-06	Johnson & Johnson Vision Care, Inc.	Ophthalmic devices containing heterocyclic compounds and methods for their production
US20040150788A1 (en)	2002-11-22	2004-08-05	Ann-Margret Andersson	Antimicrobial lenses, processes to prepare them and methods of their use
US7416737B2 (en)	2003-11-18	2008-08-26	Johnson & Johnson Vision Care, Inc.	Antimicrobial lenses, processes to prepare them and methods of their use
US9052438B2 (en)	2005-04-08	2015-06-09	Johnson & Johnson Vision Care, Inc.	Ophthalmic devices comprising photochromic materials with reactive substituents
US8158037B2 (en)	2005-04-08	2012-04-17	Johnson & Johnson Vision Care, Inc.	Photochromic materials having extended pi-conjugated systems and compositions and articles including the same
US7968650B2 (en)	2006-10-31	2011-06-28	Johnson & Johnson Vision Care, Inc.	Polymeric compositions comprising at least one volume excluding polymer
US20080102095A1 (en)	2006-10-31	2008-05-01	Kent Young	Acidic processes to prepare antimicrobial contact lenses
KR100885819B1 (ko) *	2007-12-18	2009-02-26	제일모직주식회사	굴절률이 우수한 분지형 아크릴계 공중합체 및 그 제조방법
US9690115B2 (en)	2010-04-13	2017-06-27	Johnson & Johnson Vision Care, Inc.	Contact lenses displaying reduced indoor glare
US8877103B2 (en)	2010-04-13	2014-11-04	Johnson & Johnson Vision Care, Inc.	Process for manufacture of a thermochromic contact lens material
US8697770B2 (en)	2010-04-13	2014-04-15	Johnson & Johnson Vision Care, Inc.	Pupil-only photochromic contact lenses displaying desirable optics and comfort
WO2012023454A1 (fr) *	2010-08-16	2012-02-23	学校法人愛知学院	Résine à mémoire de forme, appareil orthodontique l'utilisant, et procédé de contrôle de la propriété viscoélastique de la résine à mémoire de forme
WO2012122320A2 (fr) *	2011-03-07	2012-09-13	The Regents Of The University Of Colorado, A Body Corporate	Lentilles intraoculaires en polymère à mémoire de forme
WO2012161100A1 (fr) *	2011-05-23	2012-11-29	パナソニック株式会社	Composition de résine méthacrylique et produit moulé à base de celle-ci
US8865685B2 (en)	2011-06-30	2014-10-21	Johnson & Johnson Vision Care, Inc.	Esters for treatment of ocular inflammatory conditions
US20130083286A1 (en)	2011-09-30	2013-04-04	Johnson & Johnson Vision Care, Inc.	Method of creating a visible mark on lens using a leuco dye
US20130083287A1 (en)	2011-09-30	2013-04-04	Johnson & Johnson Vision Care, Inc.	Method of creating a visible mark on lens using a leuco dye
JP6829958B2 (ja) *	2016-07-11	2021-02-17	大阪有機化学工業株式会社	シクロヘキシル（メタ）アクリレート組成物
US11724471B2 (en)	2019-03-28	2023-08-15	Johnson & Johnson Vision Care, Inc.	Methods for the manufacture of photoabsorbing contact lenses and photoabsorbing contact lenses produced thereby

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Publication number	Priority date	Publication date	Assignee	Title
JP2517281B2 (ja) *	1987-05-28	1996-07-24	富士写真フイルム株式会社	光重合性組成物
US4834750A (en) *	1987-09-17	1989-05-30	Ioptex Research, Inc.	Deformable-elastic intraocular lens
EP0514096A3 (en) *	1991-05-13	1993-03-31	Ioptex Research Inc.	Deformable-elastic intraocular lens
JP3191011B2 (ja) *	1992-06-02	2001-07-23	日立金属株式会社	２成分現像剤
US5331073A (en) *	1992-11-09	1994-07-19	Allergan, Inc.	Polymeric compositions and intraocular lenses made from same
CA2138299C (fr) *	1993-04-30	1998-07-14	Albert R. Leboeuf	Methode pour la reduction du caractere poisseux de polymeres acryliques mous
JP2967093B2 (ja) *	1995-02-23	1999-10-25	ホーヤ株式会社	軟性眼内レンズ
JPH08299373A (ja) *	1995-05-12	1996-11-19	Hoya Corp	軟性眼内レンズ及びその製造方法
JP3429392B2 (ja) *	1995-05-24	2003-07-22	Ｈｏｙａ株式会社	軟性眼内レンズ

1999
- 1999-10-25 JP JP2000580024A patent/JP2002529759A/ja active Pending
- 1999-10-25 EP EP99965729A patent/EP1137956A1/fr not_active Withdrawn
- 1999-10-25 WO PCT/US1999/024982 patent/WO2000026698A1/fr not_active Ceased
- 1999-10-25 AU AU46087/01A patent/AU760960B2/en not_active Ceased
- 1999-10-25 BR BR9914904-4A patent/BR9914904A/pt not_active IP Right Cessation
- 1999-10-25 CA CA002348495A patent/CA2348495C/fr not_active Expired - Lifetime
2007
- 2007-05-16 JP JP2007130415A patent/JP5096793B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP5096793B2 (ja)	2012-12-12
EP1137956A1 (fr)	2001-10-04
BR9914904A (pt)	2001-08-07
WO2000026698A1 (fr)	2000-05-11
JP2007262414A (ja)	2007-10-11
WO2000026698A8 (fr)	2001-09-13
AU4608701A (en)	2002-02-05
CA2348495A1 (fr)	2000-05-11
WO2000026698B1 (fr)	2000-07-13
JP2002529759A (ja)	2002-09-10
AU760960B2 (en)	2003-05-22

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Date	Code	Title	Description
2002-12-18	EEER	Examination request
2019-12-29	MKEX	Expiry	Effective date: 20191025

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