CA2350233A1 - Mammiferes transgeniques et clones - Google Patents

Mammiferes transgeniques et clones Download PDF

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Publication number
CA2350233A1
CA2350233A1 CA002350233A CA2350233A CA2350233A1 CA 2350233 A1 CA2350233 A1 CA 2350233A1 CA 002350233 A CA002350233 A CA 002350233A CA 2350233 A CA2350233 A CA 2350233A CA 2350233 A1 CA2350233 A1 CA 2350233A1
Authority
CA
Canada
Prior art keywords
cell
human
mammal
promoter
somatic cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002350233A
Other languages
English (en)
Inventor
Yann Echelard
Esmail Behbodi
Carol Ziomek
William Gavin
David Melican
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
GTC Biotherapeutics Inc
Tufts University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/298,971 external-priority patent/US6580017B1/en
Application filed by GTC Biotherapeutics Inc, Tufts University filed Critical GTC Biotherapeutics Inc
Priority to CA002431859A priority Critical patent/CA2431859C/fr
Publication of CA2350233A1 publication Critical patent/CA2350233A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8772—Caprine embryos
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0273—Cloned vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/102—Caprine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention présente des procédés permettant de produire des mammifères (p.ex. chèvres) clonés ou transgéniques. Parmi les procédés figurent la réalisation d'une lignée cellulaire somatique, p.ex. une lignée cellulaire somatique transgénique pouvant être utilisée comme cellule donneuse; des procédés de production d'un mammifère cloné ou transgénique par l'introduction du génome d'une cellule somatique dans un ovocyte énucléé, de préférence ayant atteint maturation de manière naturelle en au stade de télophase, afin de former un embryon reconstitué; ainsi que des procédés de transfert de l'embryon reconstitué. L'invention concerne aussi des lignées cellulaires, des embryons reconstitués et des mammifères clonés ou transgéniques.
CA002350233A 1998-11-02 1999-11-02 Mammiferes transgeniques et clones Abandoned CA2350233A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002431859A CA2431859C (fr) 1998-11-02 1999-11-02 Mammiferes transgeniques et clones

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US10672898P 1998-11-02 1998-11-02
US60/106,728 1998-11-02
US29850899A 1999-04-22 1999-04-22
US09/298,508 1999-04-22
US09/298,971 US6580017B1 (en) 1998-11-02 1999-04-23 Methods of reconstructed goat embryo transfer
US09/298,971 1999-04-23
US13132899P 1999-04-26 1999-04-26
US60/131,328 1999-04-26
PCT/US1999/025710 WO2000026357A2 (fr) 1998-11-02 1999-11-02 Mammiferes transgeniques et clones

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002431859A Division CA2431859C (fr) 1998-11-02 1999-11-02 Mammiferes transgeniques et clones

Publications (1)

Publication Number Publication Date
CA2350233A1 true CA2350233A1 (fr) 2000-05-11

Family

ID=27493534

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002350233A Abandoned CA2350233A1 (fr) 1998-11-02 1999-11-02 Mammiferes transgeniques et clones

Country Status (5)

Country Link
EP (1) EP1127113A2 (fr)
JP (2) JP4523165B2 (fr)
AU (1) AU1462200A (fr)
CA (1) CA2350233A1 (fr)
WO (1) WO2000026357A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6781030B1 (en) 1998-11-02 2004-08-24 Trustee Of Tufts College, Ballou Hall Methods for cloning mammals using telophase oocytes
US8030537B1 (en) * 2000-07-27 2011-10-04 Apogene Gmbh & Co. Kg Somatic cloning gene transfer for the production of recombinant proteins, cells and organs
KR20040065214A (ko) * 2001-11-06 2004-07-21 샹하이 세컨드 메디컬 유니버시티 토끼 난모세포를 이용한 체세포 배아의 제조방법
US7612250B2 (en) 2002-07-29 2009-11-03 Trustees Of Tufts College Nuclear transfer embryo formation method
EP1534065A4 (fr) * 2002-08-01 2005-11-09 Gtc Biotherapeutics Inc Procede destine a selectionner de facon rapide des lignes de cellules primaires homozygotes en vue de produire des animaux transgeniques par transfert nucleaire de cellules somatiques
WO2011060489A1 (fr) * 2009-11-18 2011-05-26 Murray Goulburn Co-Operative Co. Limited Animaux transgéniques non humains
CN104082239B (zh) * 2014-06-10 2016-01-20 张海员 一种原生态生猪专用菌种养殖方法
FR3025515B1 (fr) 2014-09-05 2016-09-09 Lab Francais Du Fractionnement Procede de purification d'un anticorps monoclonal
JP6929527B2 (ja) 2015-03-04 2021-09-01 株式会社ポル・メド・テック 安定した表現型を示す疾患モデルブタおよびその作製方法
FR3034420A1 (fr) 2015-03-31 2016-10-07 Lab Francais Du Fractionnement Anticorps monoclonaux anti-cd303
EP3497230A1 (fr) 2016-08-15 2019-06-19 Danmarks Tekniske Universitet Procédé de réduction de la production d'ammonium et de lactate dans des cellules de cho
FR3060395B1 (fr) 2016-12-16 2019-05-24 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Combinaison d'anticorps anti-cd303 et anti-her2
FR3060394B1 (fr) 2016-12-16 2019-05-24 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Combinaison d'anticorps anti-cd303 et anti-amhrii
FR3076294B1 (fr) 2017-12-29 2022-01-28 Lab Francais Du Fractionnement Procede de purification d'anticorps a partir de lait brut
CN109315355A (zh) * 2018-11-21 2019-02-12 江西和乐园生态农业科技发展有限公司 一种山羊养殖方法
CA3223956A1 (fr) 2021-12-20 2023-06-29 Vetoquinol Sa Anticorps anti-recepteur a de l'interleukine-31 canin (il-31ra) et leurs utilisations
EP4662240A2 (fr) 2023-02-09 2025-12-17 Commissariat à l'Energie Atomique et aux Energies Alternatives Fragment fab mutant pour l'obtention de conjugués mono- ou bi-fonctionnalisés site-spécifiques
WO2025114614A1 (fr) 2023-11-30 2025-06-05 Vetoquinol Sa Anticorps anti-récepteurs alpha de l'interleukine-4 canins (il-4rα) et leurs utilisations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843705A (en) * 1995-02-21 1998-12-01 Genzyme Transgenic Corporation Transgenically produced antithrombin III
GB9517780D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US5907080A (en) * 1995-11-30 1999-05-25 Nexia Biotechnologies, Inc. Method for development of transgenic dwarf goats

Also Published As

Publication number Publication date
EP1127113A2 (fr) 2001-08-29
JP2002528117A (ja) 2002-09-03
AU1462200A (en) 2000-05-22
JP4523165B2 (ja) 2010-08-11
JP4068516B2 (ja) 2008-03-26
JP2004073189A (ja) 2004-03-11
WO2000026357A3 (fr) 2000-11-23
WO2000026357A2 (fr) 2000-05-11

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued