CA2360670A1 - Production de peptides et de proteines biomedicaux dans les plantes par utilisation des systemes de transcomplementation - Google Patents

Production de peptides et de proteines biomedicaux dans les plantes par utilisation des systemes de transcomplementation Download PDF

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Publication number
CA2360670A1
CA2360670A1 CA002360670A CA2360670A CA2360670A1 CA 2360670 A1 CA2360670 A1 CA 2360670A1 CA 002360670 A CA002360670 A CA 002360670A CA 2360670 A CA2360670 A CA 2360670A CA 2360670 A1 CA2360670 A1 CA 2360670A1
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CA
Canada
Prior art keywords
virus
nucleic acid
acid sequence
recombinant
encoding nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002360670A
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English (en)
Inventor
Hilary Koprowski
Vidadi Yusibov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thomas Jefferson University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2360670A1 publication Critical patent/CA2360670A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
    • C12N15/8203—Virus mediated transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne des procédés permettant de produire des polypeptides étrangers dans une plante hôte en utilisant des virus de recombinaison par le biais de systèmes de complémentation fonctionnelle. On construit pour cela des vecteurs viraux de recombinaison appropriés, capables d'engendrer une infection systémique et d'infecter les plantes hôtes par le biais d'un ou plusieurs vecteurs viraux de recombinaison. Par ailleurs, on infecte une plante hôte qui est transgénique pour l'expression des gènes de réplicase de virus, moyennant quoi la plante transgénique exprimant les gènes en question assure la complémentation de la fonction de réplicase de virus. L'invention concerne en outre des compositions renfermant des vecteurs viraux de recombinaison capables d'engendrer une infection systémique, pour la production de polypeptides étrangers dans une plante hôte.
CA002360670A 1999-02-05 2000-02-04 Production de peptides et de proteines biomedicaux dans les plantes par utilisation des systemes de transcomplementation Abandoned CA2360670A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11886799P 1999-02-05 1999-02-05
US60/118,867 1999-02-05
PCT/US2000/002971 WO2000046350A1 (fr) 1999-02-05 2000-02-04 Production de peptides et de proteines biomedicaux dans les plantes par utilisation des systemes de transcomplementation

Publications (1)

Publication Number Publication Date
CA2360670A1 true CA2360670A1 (fr) 2000-08-10

Family

ID=22381232

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002360670A Abandoned CA2360670A1 (fr) 1999-02-05 2000-02-04 Production de peptides et de proteines biomedicaux dans les plantes par utilisation des systemes de transcomplementation

Country Status (4)

Country Link
EP (1) EP1147178A1 (fr)
JP (1) JP2003517280A (fr)
CA (1) CA2360670A1 (fr)
WO (1) WO2000046350A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7193128B2 (en) 1997-06-03 2007-03-20 Chromatin, Inc. Methods for generating or increasing revenues from crops
US7119250B2 (en) 1997-06-03 2006-10-10 The University Of Chicago Plant centromere compositions
US7235716B2 (en) 1997-06-03 2007-06-26 Chromatin, Inc. Plant centromere compositions
US7227057B2 (en) 1997-06-03 2007-06-05 Chromatin, Inc. Plant centromere compositions
WO2004044161A2 (fr) 2002-11-06 2004-05-27 Fraunhofer Usa Expression de sequences etrangeres dans des vegetaux utilisant un systeme de transactivation
US7683238B2 (en) * 2002-11-12 2010-03-23 iBio, Inc. and Fraunhofer USA, Inc. Production of pharmaceutically active proteins in sprouted seedlings
EP1594956A4 (fr) * 2003-02-03 2007-08-01 Fraunhofer Usa Inc Systeme d'expression de genes dans des plantes
CA2526720C (fr) 2003-05-22 2013-10-22 Fraunhofer Usa, Inc. Molecule support recombinee pour l'expression, l'administration et la purification de polypeptides cibles
WO2007117264A2 (fr) 2005-08-03 2007-10-18 Fraunhofer Usa, Inc. Compositions et procedes de production d'immunoglobulines
AU2007215080A1 (en) 2006-02-13 2007-08-23 Fraunhofer Usa, Inc. Influenza antigens, vaccine compositions, and related methods
EP2178558B1 (fr) 2007-07-11 2014-04-30 iBio, Inc. Antigènes yersinia pestis, compositions de vaccins, et méthodes associées
US8734803B2 (en) 2008-09-28 2014-05-27 Ibio Inc. Humanized neuraminidase antibody and methods of use thereof
GB0817978D0 (en) * 2008-10-01 2008-11-05 Imp Innovations Ltd Peptides
EP2456894A4 (fr) 2009-07-23 2013-09-25 Chromatin Inc Séquences de centromère et mini-chromosomes de sorgho
US8784819B2 (en) 2009-09-29 2014-07-22 Ibio Inc. Influenza hemagglutinin antibodies, compositions and related methods
BR112013001544A2 (pt) * 2010-07-19 2016-05-10 Univ California produção baseada em planta de proteínas heterólogas.
AU2014234251A1 (en) 2013-03-22 2015-06-18 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Kits comprising plus-sense single stranded RNA viral vectors and methods for producing polypeptides using the kits
EP3303383A1 (fr) 2015-06-05 2018-04-11 iBio, Inc. Fragments et variants d'endostatine pour utilisation dans le traitement de la fibrose
CA3228786A1 (fr) 2021-08-25 2023-03-02 Ibio, Inc. Anticorps anti-cd25

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5316931A (en) * 1988-02-26 1994-05-31 Biosource Genetics Corp. Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes
US6042832A (en) * 1996-08-28 2000-03-28 Thomas Jefferson University Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins

Also Published As

Publication number Publication date
JP2003517280A (ja) 2003-05-27
WO2000046350A1 (fr) 2000-08-10
EP1147178A1 (fr) 2001-10-24

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