CA2366062C - Proteine humaine et molecules d'acide nucleique associees a dickkopf et leurs utilisations - Google Patents

Proteine humaine et molecules d'acide nucleique associees a dickkopf et leurs utilisations Download PDF

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Publication number
CA2366062C
CA2366062C CA2366062A CA2366062A CA2366062C CA 2366062 C CA2366062 C CA 2366062C CA 2366062 A CA2366062 A CA 2366062A CA 2366062 A CA2366062 A CA 2366062A CA 2366062 C CA2366062 C CA 2366062C
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Canada
Prior art keywords
dkk
seq
protein
nucleic acid
amino acid
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Expired - Lifetime
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CA2366062A
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English (en)
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CA2366062A1 (fr
Inventor
Sean Mccarthy
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Millennium Pharmaceuticals Inc
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Millennium Pharmaceuticals Inc
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Publication of CA2366062A1 publication Critical patent/CA2366062A1/fr
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Publication of CA2366062C publication Critical patent/CA2366062C/fr
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4718—Cytokine-induced proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne de nouveaux polypeptides, de nouvelles protéines et de nouvelles molécules d'acide nucléique Dkk et associées à Dkk. En plus de protéines Dkk et associées à Dkk isolées et complètes, l'invention concerne également des protéines de fusion isolées, des peptides antigéniques et des anticorps. L'invention concerne en outre des molécules d'acide nucléique Dkk et associées à Dkk, des vecteurs d'expression recombinants contenant une molécule d'acide nucléique de la présente invention, des cellules hôtes dans lesquelles on a introduit lesdits vecteurs d'expression et des animaux transgéniques non humains dans lesquels un gène Dkk ou associé à Dkk a été introduit ou dissocié. L'invention concerne par ailleurs des méthodes diagnostiques, thérapeutiques et de criblage qui utilisent les compositions de la présente invention.
CA2366062A 1999-03-05 2000-03-03 Proteine humaine et molecules d'acide nucleique associees a dickkopf et leurs utilisations Expired - Lifetime CA2366062C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26302299A 1999-03-05 1999-03-05
US09/263,022 1999-03-05
PCT/US2000/005452 WO2000052047A2 (fr) 1999-03-05 2000-03-03 Proteine humaine et molecules d'acide nucleique associees a dickkopf et leurs utilisations

Publications (2)

Publication Number Publication Date
CA2366062A1 CA2366062A1 (fr) 2000-09-08
CA2366062C true CA2366062C (fr) 2014-06-17

Family

ID=23000057

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2366062A Expired - Lifetime CA2366062C (fr) 1999-03-05 2000-03-03 Proteine humaine et molecules d'acide nucleique associees a dickkopf et leurs utilisations

Country Status (4)

Country Link
EP (1) EP1161445A2 (fr)
AU (1) AU3510200A (fr)
CA (1) CA2366062C (fr)
WO (1) WO2000052047A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE255229T1 (de) * 2000-02-24 2003-12-15 Oxford Glycosciences Uk Ltd Dpi-6, ein therapeutischer biomarker in neurologischen krankheiten
EP1222933A1 (fr) * 2001-01-15 2002-07-17 Academisch Ziekenhuis Leiden h.o.d.n., Leids Universitair Medisch Centrum Génération et/ou réduction de nouveau tissu pulmonaire dans un poumon atteint, par modulation de la voie Wnt
HUP0303194A2 (hu) * 2001-02-16 2003-12-29 Genentech, Inc. DKK-1 és antagonistái alkalmazásai
EP1573024A4 (fr) 2001-04-10 2007-08-29 Agensys Inc Acides nucleiques et proteines correspondantes utiles pour la detection et le traitement de divers cancers
US20040038860A1 (en) 2002-05-17 2004-02-26 Allen Kristina M. Reagents and methods for modulating dkk-mediated interactions
EP1395285A4 (fr) * 2001-05-17 2005-06-01 Genome Therapeutics Corp Reactifs et procedes destines a moduler des interactions induites par dkk
ES2304210B1 (es) * 2002-10-15 2009-09-28 Genentech, Inc Utilizacion de dkk-5, procedimiento y equipo de diagnostico de trastornos resistentes a la insulina e hibridoma y anticuerpo contra dkk-5.
US7811750B2 (en) * 2002-12-05 2010-10-12 Board Of Trustees Of The University Of Arkansas Molecular determinants of myeloma bone disease and use thereof
US8124087B2 (en) 2002-12-05 2012-02-28 Board Of Trustees Of The University Of Arkansas Methods of controlling bone loss by inhibiting DKK1
MXPA05006033A (es) * 2002-12-05 2006-03-08 Univ Arkansas Determinantes moleculares de enfermedad osea por mieloma, y usos de los mismos.
US8637506B2 (en) * 2003-09-22 2014-01-28 Enzo Biochem, Inc. Compositions and methods for bone formation and remodeling
US7622553B2 (en) 2003-11-17 2009-11-24 Merck & Co., Inc. Rhesus monkey dickkopf-1, nucleotides encoding same, and uses thereof
US7473770B2 (en) 2003-11-17 2009-01-06 Merck & Co., Inc. Cynomolgus monkey dickkopf-4, nucleotides encoding same, and uses thereof
US8343922B2 (en) * 2004-05-19 2013-01-01 Enzo Biochem, Inc. Compositions and methods for the stimulation or enhancement of bone formation and the self-renewal of cells
WO2006010534A1 (fr) * 2004-07-28 2006-02-02 F.Hoffmann-La Roche Ag Dickkopf 3 en tant que cible / marqueur de la defaillance des cellules beta
ES2414460T3 (es) 2004-08-04 2013-07-19 Amgen Inc. Anticuerpos para Dkk-1
US8252267B2 (en) 2005-03-30 2012-08-28 Sagres Discovery, Inc. DKKL-1 splice product modulators for cancer diagnosis and therapy
WO2007104181A1 (fr) * 2006-03-13 2007-09-20 Shanghai Cancer Institute Utilisations de la protéine dkk-1 dans le diagnostic de cancers
CN103080309B (zh) * 2010-07-01 2015-11-25 国立大学法人冈山大学 REIC/Dkk-3蛋白的部分区域多肽
KR20130021315A (ko) * 2011-08-22 2013-03-05 인하대학교 산학협력단 Ｄｋｋ2 단백질 또는 그 유전자를 포함하는 발기부전 예방 또는 치료용 조성물 및 그의 용도
WO2020261100A1 (fr) * 2019-06-25 2020-12-30 Friedrich Miescher Institute For Biomedical Research Promoteur pour l'expression spécifique de gènes dans des cellules exprimant une protéine acide fibrillaire gliale

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998027932A2 (fr) * 1996-12-20 1998-07-02 Human Genome Sciences, Inc. Proteine specifique du cervelet et de l'embryon
DE69842225D1 (de) * 1997-04-16 2011-05-26 Millennium Pharm Inc Zusammensetzung, umfassend einen Antikörper, der selektiv an ein cysteinreiches sekretiertes Protein (CRSP) bindet
DE19747418C1 (de) * 1997-10-27 1999-07-15 Deutsches Krebsforsch Inhibitor-Protein des wnt-Signalwegs
DE19844293C2 (de) * 1998-09-18 2002-03-14 B & S Elektronische Geraete Gm Beleuchtungseinrichtung

Also Published As

Publication number Publication date
EP1161445A2 (fr) 2001-12-12
WO2000052047A9 (fr) 2002-03-14
WO2000052047A3 (fr) 2001-02-01
CA2366062A1 (fr) 2000-09-08
WO2000052047A2 (fr) 2000-09-08
AU3510200A (en) 2000-09-21

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