CA2372393A1 - Nouvelles proteines a action insulinoide utilisees dans le traitement du diabete - Google Patents

Nouvelles proteines a action insulinoide utilisees dans le traitement du diabete Download PDF

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Publication number: CA2372393A1
Authority: CA; Canada
Prior art keywords: protein; insulin; sequence; amino acid; residues
Prior art date: 1999-05-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002372393A

Other languages

English (en)

Inventor

Bassil I. Dahiyat

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Xencor Inc

Original Assignee

Xencor Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-19

Filing date

2000-05-19

Publication date

2000-11-23

2000-05-19 Application filed by Xencor Inc filed Critical Xencor Inc

2000-11-23 Publication of CA2372393A1 publication Critical patent/CA2372393A1/fr

Status Abandoned legal-status Critical Current

Links

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VBIZUNYMJSPHBH-OQLLNIDSSA-N salinazid Chemical compound OC1=CC=CC=C1\C=N\NC(=O)C1=CC=NC=C1 VBIZUNYMJSPHBH-OQLLNIDSSA-N 0.000 description 1
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IHQKEDIOMGYHEB-UHFFFAOYSA-M sodium dimethylarsinate Chemical compound [Na+].C[As](C)([O-])=O IHQKEDIOMGYHEB-UHFFFAOYSA-M 0.000 description 1
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JBQYATWDVHIOAR-UHFFFAOYSA-N tellanylidenegermanium Chemical compound [Te]=[Ge] JBQYATWDVHIOAR-UHFFFAOYSA-N 0.000 description 1
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FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
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MEYZYGMYMLNUHJ-UHFFFAOYSA-N tunicamycin Natural products CC(C)CCCCCCCCCC=CC(=O)NC1C(O)C(O)C(CC(O)C2OC(C(O)C2O)N3C=CC(=O)NC3=O)OC1OC4OC(CO)C(O)C(O)C4NC(=O)C MEYZYGMYMLNUHJ-UHFFFAOYSA-N 0.000 description 1
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241000701447 unidentified baculovirus Species 0.000 description 1
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230000002792 vascular Effects 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Obesity (AREA)
Public Health (AREA)
Toxicology (AREA)
Emergency Medicine (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

CA002372393A 1999-05-19 2000-05-19 Nouvelles proteines a action insulinoide utilisees dans le traitement du diabete Abandoned CA2372393A1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US13493099P	1999-05-19	1999-05-19
US60/134,930		1999-05-19
PCT/US2000/013764 WO2000069901A2 (fr)	1999-05-19	2000-05-19	Nouvelles proteines a action insulinoide utilisees dans le traitement du diabete

Publications (1)

Publication Number	Publication Date
CA2372393A1 true CA2372393A1 (fr)	2000-11-23

Family

ID=22465651

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002372393A Abandoned CA2372393A1 (fr)	1999-05-19	2000-05-19	Nouvelles proteines a action insulinoide utilisees dans le traitement du diabete

Country Status (4)

Country	Link
JP (1)	JP2003518917A (fr)
AU (1)	AU5144400A (fr)
CA (1)	CA2372393A1 (fr)
WO (1)	WO2000069901A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2329220T3 (es)	1999-01-06	2009-11-24	Genentech, Inc.	Variantes mutantes del factor de crecimiento similar a insulina (igf) i.
AU762351B2 (en)	1999-01-06	2003-06-26	Genentech Inc.	Insulin-like growth factor (IGF) I mutant variants
AU2001263215A1 (en)	2000-05-16	2001-11-26	Genentech Inc.	Method for treating cartilage disorders
EP1644411A2 (fr) *	2003-07-11	2006-04-12	Novo Nordisk A/S	Compositions d'insuline stabilisee
CN101541830A (zh)	2006-09-22	2009-09-23	诺沃-诺迪斯克有限公司	蛋白酶抗性的胰岛素类似物
CN101970477B (zh)	2008-03-14	2014-12-31	诺沃-诺迪斯克有限公司	蛋白酶稳定的胰岛素类似物
HUE032284T2 (en)	2008-03-18	2017-09-28	Novo Nordisk As	Protease-stabilized, acylated insulin analogues
EP2376531A1 (fr) *	2008-12-09	2011-10-19	Novo Nordisk A/S	Nouveaux analogues de l'insuline
CN103533952B (zh)	2011-03-15	2017-02-15	诺沃—诺迪斯克有限公司	包含半胱氨酸置换的人胰岛素类似物和衍生物
CA2926701A1 (fr)	2013-10-07	2015-04-16	Novo Nordisk A/S	Nouveau derive d'un analogue de l'insuline
ES2886837T3 (es)	2016-12-16	2021-12-21	Novo Nordisk As	Composiciones farmacéuticas que contienen insulina
CA3071686A1 (fr) *	2017-08-17	2019-02-21	Novo Nordisk A/S	Nouveaux analogues d'insuline acyles et leurs utilisations
CN112843081B (zh) *	2021-02-02	2022-07-05	四川大学	一种dna四面体-白藜芦醇复合物及其制备方法和用途
CN112843082B (zh) *	2021-02-02	2022-07-05	四川大学	Dna四面体在制备治疗糖尿病的药物中的用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5268453A (en) *	1991-08-08	1993-12-07	Scios Inc.	Tissue-selective insulin analogs

2000
- 2000-05-19 CA CA002372393A patent/CA2372393A1/fr not_active Abandoned
- 2000-05-19 WO PCT/US2000/013764 patent/WO2000069901A2/fr not_active Ceased
- 2000-05-19 AU AU51444/00A patent/AU5144400A/en not_active Abandoned
- 2000-05-19 JP JP2000618317A patent/JP2003518917A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
WO2000069901A3 (fr)	2002-09-12
AU5144400A (en)	2000-12-05
WO2000069901A2 (fr)	2000-11-23
JP2003518917A (ja)	2003-06-17

Legal Events

Date	Code	Title	Description
2001-11-14	EEER	Examination request
2003-05-20	FZDE	Dead

Publication	Publication Date	Title
US6746853B1 (en)	2004-06-08	Proteins with insulin-like activity useful in the treatment of diabetes
US7101974B2 (en)	2006-09-05	TNF-αvariants
US6514729B1 (en)	2003-02-04	Recombinant interferon-beta muteins
US7056695B2 (en)	2006-06-06	TNF-α variants
US7244823B2 (en)	2007-07-17	TNF-alpha variants proteins for the treatment of TNF-alpha related disorders
US7687461B2 (en)	2010-03-30	Treatment of TNF-α related disorders with TNF-α variant proteins
CA2401683A1 (fr)	2001-09-07	Conception et decouverte de variants du tnf-.alpha. a base de proteines destines au traitement des pathologies liees au tnf-.alpha.
AU5144400A (en)	2000-12-05	Novel proteins with insulin-like activity useful in the treatment of diabetes
US6946265B1 (en)	2005-09-20	Nucleic acids and proteins with growth hormone activity
AU2009203094A1 (en)	2009-08-20	Protein based TNF-alpha variants for the treatment of TNF-alpha related disorders
CA2372881A1 (fr)	2000-11-16	Nouveaux acides nucleiques et proteines ayant une activite p53 et comportant des domaines de tetramerisation modifies
WO2000068385A9 (fr)	2002-04-18	Nouveaux acides nucleiques et proteines a activite d'hormone de croissance
AU2001245411B2 (en)	2005-09-01	Design and discovery of protein based TNF-alpha variants for the treatment of TNF-alpha related disorders
AU2002334766B2 (en)	2007-03-08	Protein based TNF-alpha variants for the treatment of TNF-alpha related disorders
AU2001245411A1 (en)	2001-11-22	Design and discovery of protein based TNF-alpha variants for the treatment of TNF-alpha related disorders
AU2005239700A1 (en)	2005-12-22	Design and discovery of protein based TNF-alpha variants for the treatment of TNF-alpha related disorders
AU2002334766A1 (en)	2003-07-03	Protein based TNF-alpha variants for the treatment of TNF-alpha related disorders
KR19980701798A (ko)	1998-06-25	비만 억제 단백질