CA2372960C - Compositions et procedes immunogenes anti-vih - Google Patents
Compositions et procedes immunogenes anti-vih Download PDFInfo
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- CA2372960C CA2372960C CA002372960A CA2372960A CA2372960C CA 2372960 C CA2372960 C CA 2372960C CA 002372960 A CA002372960 A CA 002372960A CA 2372960 A CA2372960 A CA 2372960A CA 2372960 C CA2372960 C CA 2372960C
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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Abstract
L'invention concerne des compositions immunogènes qui améliorent les taux de beta -chimiokine chez le mammifère. Ces compositions immunogènes contiennent un antigène anti-VIH, une molécule d'acide nucléique isolée contenant une séquence immunostimulante et un adjuvant. L'antigène anti-VIH peut être un virus VIH totalement inactivé, dépourvu de la protéine d'enveloppe extérieure gp120. Par ailleurs, l'antigène anti-VIH peut être un virus VIH totalement inactivé, ou un antigène p24. L'invention concerne également des trousses dont les composants, une fois combinés, produisent les compositions immunogènes selon l'invention. L'invention traite également de procédés de fabrication des compositions immunogènes, en combinant un antigène anti-VIH, une molécule d'acide nucléique isolée contenant une séquence immunostimulante et un adjuvant. L'invention traite également d'un procédé permettant d'immuniser un mammifère, en lui administrant une composition immunogène contenant un antigène anti-VIH, une molécule d'acide nucléique isolée contenant une séquence immunostimulante et un adjuvant. L'invention a aussi pour objet un procédé permettant d'inhiber le SIDA, en renforçant la production de beta -chimiokine chez le mammifère, en administrant à ce dernier une composition immunogène contenant un antigène de VIH, une molécule d'acide nucléique isolée contenant une séquence immunostimulante et un adjuvant.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13276299P | 1999-05-06 | 1999-05-06 | |
| US60/132,762 | 1999-05-06 | ||
| US15066799P | 1999-08-25 | 1999-08-25 | |
| US60/150,667 | 1999-08-25 | ||
| PCT/US2000/012495 WO2000067787A2 (fr) | 1999-05-06 | 2000-05-05 | Compositions et procedes immunogenes anti-vih |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2372960A1 CA2372960A1 (fr) | 2000-11-16 |
| CA2372960C true CA2372960C (fr) | 2006-03-28 |
Family
ID=26830710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002372960A Expired - Fee Related CA2372960C (fr) | 1999-05-06 | 2000-05-05 | Compositions et procedes immunogenes anti-vih |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1176978A2 (fr) |
| AP (1) | AP1891A (fr) |
| AU (1) | AU4992900A (fr) |
| BR (1) | BR0010323A (fr) |
| CA (1) | CA2372960C (fr) |
| CR (1) | CR6491A (fr) |
| OA (1) | OA11937A (fr) |
| WO (1) | WO2000067787A2 (fr) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| SI1077722T1 (sl) | 1998-05-22 | 2007-02-28 | Ottawa Health Research Inst | Metode in produkti za induciranje sluznicne imunosti |
| AU2221600A (en) | 1998-12-31 | 2000-07-31 | Chiron Corporation | Improved expression of hiv polypeptides and production of virus-like particles |
| AU2487300A (en) | 1998-12-31 | 2000-07-31 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| ES2572834T3 (es) | 1999-02-17 | 2016-06-02 | Csl Limited | Complejos inmunogénicos y métodos relacionados con los mismos |
| US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| AU5821000A (en) * | 1999-06-29 | 2001-01-31 | Smithkline Beecham Biologicals (Sa) | Vaccine |
| AU2001227889A1 (en) | 2000-01-14 | 2001-07-24 | The United States of America, represented by The Secretary, Department of Health & Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| KR100881923B1 (ko) | 2000-12-27 | 2009-02-04 | 다이나박스 테크놀로지 코퍼레이션 | 면역자극 폴리뉴클레오티드 및 그것의 사용 방법 |
| SG152045A1 (en) * | 2001-01-26 | 2009-05-29 | Immune Response Corp Inc | Method for treating an hiv-infected individual by combining immunization with structured interruption of anti-retroviral treatment |
| EP2423335B1 (fr) | 2001-06-21 | 2014-05-14 | Dynavax Technologies Corporation | Composés immunomodulateurs chimères et leur procédé d'utilisation |
| EP1411770A4 (fr) | 2001-07-05 | 2006-05-10 | Chiron Corp | Polynucleotides codant des polypeptides de type c du vih antigeniques, polypeptides et leurs utilisations |
| WO2003020884A2 (fr) | 2001-08-14 | 2003-03-13 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Procede de generation rapide de cellules dentritique matures |
| ATE411054T1 (de) | 2001-08-17 | 2008-10-15 | Coley Pharm Gmbh | Kombinations-motif-immunstimulierende oligonukleotide mit verbesserter wirkung |
| US20030170614A1 (en) | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
| AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| WO2003054161A2 (fr) | 2001-12-20 | 2003-07-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Utilisation d'oligodeoxynucleotides cpg en vue d'induire l'angiogenese |
| CA2388049A1 (fr) | 2002-05-30 | 2003-11-30 | Immunotech S.A. | Oligonucleotides immunostimulateurs et utilisations connexes |
| WO2004005476A2 (fr) * | 2002-07-03 | 2004-01-15 | Coley Pharmaceutical Group, Inc. | Compositions d'acide nucleique destinees a stimuler les reponses immunitaires |
| US20040053880A1 (en) | 2002-07-03 | 2004-03-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7807803B2 (en) | 2002-07-03 | 2010-10-05 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7576066B2 (en) | 2002-07-03 | 2009-08-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7569553B2 (en) | 2002-07-03 | 2009-08-04 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7605138B2 (en) | 2002-07-03 | 2009-10-20 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| CN1753687A (zh) | 2002-10-29 | 2006-03-29 | 科勒制药集团股份有限公司 | Cpg寡核苷酸在治疗丙型肝炎病毒感染中的应用 |
| CA2502015A1 (fr) | 2002-12-11 | 2004-06-24 | Coley Pharmaceutical Group, Inc. | Acides nucleiques 5'cpg et leurs methodes d'utilisation |
| US8158768B2 (en) | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
| JP5102959B2 (ja) | 2002-12-23 | 2012-12-19 | ダイナバックス テクノロジーズ コーポレイション | 免疫刺激配列オリゴヌクレオチド及びその使用方法 |
| MXPA06001996A (es) * | 2003-08-28 | 2006-06-20 | Immune Response Corp Inc | Composiciones de hiv inmunogeneticas y metodos relacionados. |
| MY159370A (en) | 2004-10-20 | 2016-12-30 | Coley Pharm Group Inc | Semi-soft-class immunostimulatory oligonucleotides |
| PT2078080E (pt) | 2006-09-27 | 2015-09-18 | Coley Pharm Gmbh | Análogos dos oligonucleotídeos cpg que contêm análogos t hidrofóbicos com atividade imunoestimulante potenciada |
| WO2010051820A1 (fr) * | 2008-11-10 | 2010-05-14 | Aarhus Universitet | Vaccination contre multiplexée par la cytokine |
| MX350258B (es) | 2011-07-06 | 2017-08-31 | Novartis Ag | Emulsiones cationicas de aceite en agua. |
| JP6059220B2 (ja) | 2011-07-06 | 2017-01-18 | ノバルティス アーゲー | 核酸を含む水中油型エマルジョン |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1005368T3 (da) * | 1997-03-10 | 2010-01-04 | Ottawa Hospital Res Inst | Anvendelse af nukleinsyrer, der indeholder ikke-metyleret CpG dinukleotid i kombination med alun som hjælpestoffer |
| EP1003850B1 (fr) * | 1997-06-06 | 2009-05-27 | The Regents of the University of California | Inhibiteurs de l'activite de sequences immunostimulatrices de l'adn |
-
2000
- 2000-05-05 WO PCT/US2000/012495 patent/WO2000067787A2/fr not_active Ceased
- 2000-05-05 CA CA002372960A patent/CA2372960C/fr not_active Expired - Fee Related
- 2000-05-05 BR BR0010323-3A patent/BR0010323A/pt not_active IP Right Cessation
- 2000-05-05 AU AU49929/00A patent/AU4992900A/en not_active Abandoned
- 2000-05-05 EP EP00932163A patent/EP1176978A2/fr not_active Withdrawn
- 2000-05-05 AP APAP/P/2001/002300A patent/AP1891A/en active
- 2000-05-05 OA OA1200100291A patent/OA11937A/en unknown
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2001
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Also Published As
| Publication number | Publication date |
|---|---|
| BR0010323A (pt) | 2002-01-08 |
| AP1891A (en) | 2008-09-23 |
| WO2000067787A2 (fr) | 2000-11-16 |
| AU4992900A (en) | 2000-11-21 |
| EP1176978A2 (fr) | 2002-02-06 |
| CA2372960A1 (fr) | 2000-11-16 |
| OA11937A (en) | 2006-04-12 |
| AP2001002300A0 (en) | 2001-12-31 |
| CR6491A (es) | 2005-05-31 |
| WO2000067787A3 (fr) | 2001-04-26 |
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