CA2376016A1 - Synthese d'oligonucleotides utilisant des acides de lewis comme activateurs - Google Patents

Synthese d'oligonucleotides utilisant des acides de lewis comme activateurs Download PDF

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Publication number
CA2376016A1
CA2376016A1 CA002376016A CA2376016A CA2376016A1 CA 2376016 A1 CA2376016 A1 CA 2376016A1 CA 002376016 A CA002376016 A CA 002376016A CA 2376016 A CA2376016 A CA 2376016A CA 2376016 A1 CA2376016 A1 CA 2376016A1
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CA
Canada
Prior art keywords
group
chloride
composition according
alkoxy
magnesium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002376016A
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English (en)
Inventor
Xiu C. Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2376016A1 publication Critical patent/CA2376016A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé permettant d'effectuer la synthèse d'oligonucléotides par chimie des phosphoramidites, l'amélioration consistant à utiliser des acides de Lewis comme activateurs, afin de créer la liaison phosphore-oxygène.
CA002376016A 1999-06-03 2000-05-08 Synthese d'oligonucleotides utilisant des acides de lewis comme activateurs Abandoned CA2376016A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32505599A 1999-06-03 1999-06-03
US09/325,055 1999-06-03
PCT/US2000/012530 WO2000075157A1 (fr) 1999-06-03 2000-05-08 Synthese d'oligonucleotides utilisant des acides de lewis comme activateurs

Publications (1)

Publication Number Publication Date
CA2376016A1 true CA2376016A1 (fr) 2000-12-14

Family

ID=23266253

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002376016A Abandoned CA2376016A1 (fr) 1999-06-03 2000-05-08 Synthese d'oligonucleotides utilisant des acides de lewis comme activateurs

Country Status (5)

Country Link
EP (1) EP1181301A1 (fr)
JP (1) JP2003514766A (fr)
CA (1) CA2376016A1 (fr)
MX (1) MXPA01012444A (fr)
WO (1) WO2000075157A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5283178B2 (ja) * 2009-03-05 2013-09-04 株式会社島津製作所 マトリックス支援レーザ脱離イオン化質量分析用マトリックス
WO2011035250A1 (fr) 2009-09-21 2011-03-24 Gilead Sciences, Inc. Procédés et intermédiaires pour préparer des analogues de carba-nucléoside 1'-substitués
ES2524356T3 (es) 2010-07-22 2014-12-05 Gilead Sciences, Inc. Métodos y compuestos para tratar infecciones provocadas por virus Paramyxoviridae
TWI740546B (zh) * 2014-10-29 2021-09-21 美商基利科學股份有限公司 製備核糖苷的方法
HRP20220355T1 (hr) 2015-09-16 2022-05-13 Gilead Sciences, Inc. Postupci za liječenje infekcija coronaviridae
CN116036112A (zh) 2017-03-14 2023-05-02 吉利德科学公司 治疗猫冠状病毒感染的方法
WO2018204198A1 (fr) 2017-05-01 2018-11-08 Gilead Sciences, Inc. Formes cristallines de (s) 2 éthylbutyl 2 (((s) (((2r,3s,4r,5r) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazine-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)méthoxy)(phénoxy) phosphoryl)amino)propanoate
EP4512475A3 (fr) 2017-07-11 2025-05-14 Gilead Sciences, Inc. Compositions comprenant un inhibiteur de l'arn polymerase et de la cyclodextrine pour le traitement d'infections virales
AU2021214911A1 (en) 2020-01-27 2022-07-21 Gilead Sciences, Inc. Methods for treating SARS CoV-2 infections
CN118994170A (zh) 2020-03-12 2024-11-22 吉利德科学公司 制备1'-氰基核苷的方法
EP4132651B1 (fr) 2020-04-06 2026-03-18 Gilead Sciences, Inc. Formulations d'inhalation d'analogues de carbanucléosides à substitution 1'-cyano
ES3041698T3 (en) 2020-05-29 2025-11-13 Gilead Sciences Inc Remdesivir for the treatment of viral infections
CA3187821A1 (fr) 2020-06-24 2021-12-30 Gilead Sciences, Inc. Analogues de 1'-cyano nucleoside et leurs utilisations
WO2022047065A2 (fr) 2020-08-27 2022-03-03 Gilead Sciences, Inc. Composés et méthodes de traitement d'infections virales
TW202525810A (zh) 2022-03-02 2025-07-01 美商基利科學股份有限公司 用於治療病毒感染的化合物及方法
US12357577B1 (en) 2024-02-02 2025-07-15 Gilead Sciences, Inc. Pharmaceutical formulations and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08301878A (ja) * 1995-04-28 1996-11-19 Toagosei Co Ltd 三フッ化ホウ素配位化合物およびオリゴヌクレオチドの合成方法

Also Published As

Publication number Publication date
MXPA01012444A (es) 2002-07-30
EP1181301A1 (fr) 2002-02-27
WO2000075157A1 (fr) 2000-12-14
JP2003514766A (ja) 2003-04-22

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Legal Events

Date Code Title Description
FZDE Discontinued