CA2377131A1 - Agents anti-microbiens, reactifs diagnostiques et vaccins a base de constituants specifiques du parasite apicomplexan - Google Patents

Agents anti-microbiens, reactifs diagnostiques et vaccins a base de constituants specifiques du parasite apicomplexan Download PDF

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Publication number
CA2377131A1
CA2377131A1 CA002377131A CA2377131A CA2377131A1 CA 2377131 A1 CA2377131 A1 CA 2377131A1 CA 002377131 A CA002377131 A CA 002377131A CA 2377131 A CA2377131 A CA 2377131A CA 2377131 A1 CA2377131 A1 CA 2377131A1
Authority
CA
Canada
Prior art keywords
parasite
synthase
inhibitors
gene
chorismate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002377131A
Other languages
English (en)
Inventor
Rima W. Mcleod
Craig Roberts
Fiona Roberts
Jennifer Johnson
Michael Kirisits
David Ferguson
Russell Lyons
Ernest Mui
Doug Mack
Benjamin Samuel
Piotri Gornicki
Ellen Zuther
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2377131A1 publication Critical patent/CA2377131A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des utilisations de constituants de voies métaboliques de type végétal, n'incluant pas la psbA ou PPi phosphofructokinase et généralement inopérants chez les animaux ou qui sont codés par l'ADN plastidial, pour le développement de compositions entravant la croissance et la survie du parasite Apicomplexan. Les constituants de ces voies incluent notamment des enzymes, des peptides de transit et des séquences nucléotidiques codant pour les enzymes et peptides, ou des promoteurs de ces séquences nucléotidiques contre lesquels sont dirigés des anticorps, des molécules anti-sens et d'autres inhibiteurs. L'invention concerne également des réactifs diagnostiques et thérapeutiques et des vaccins développés à base de ces constituants et de leurs inhibiteurs. L'invention concerne enfin une séquence d'ADNc codant pour la charismate synthase exprimée à un stade précoce du développement de l'Apicomplexan, que l'on peut modifier afin de produire un organisme inactivé, utile dans la production de vaccins.
CA002377131A 1999-05-04 2000-04-27 Agents anti-microbiens, reactifs diagnostiques et vaccins a base de constituants specifiques du parasite apicomplexan Abandoned CA2377131A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13250699P 1999-05-04 1999-05-04
US60/132,506 1999-05-04
PCT/US2000/011478 WO2000066154A2 (fr) 1999-05-04 2000-04-27 Agents anti-microbiens, reactifs diagnostiques et vaccins a base de constituants specifiques du parasite apicomplexan

Publications (1)

Publication Number Publication Date
CA2377131A1 true CA2377131A1 (fr) 2000-11-09

Family

ID=22454357

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002377131A Abandoned CA2377131A1 (fr) 1999-05-04 2000-04-27 Agents anti-microbiens, reactifs diagnostiques et vaccins a base de constituants specifiques du parasite apicomplexan

Country Status (4)

Country Link
EP (1) EP1150709A2 (fr)
AU (1) AU767117B2 (fr)
CA (1) CA2377131A1 (fr)
WO (1) WO2000066154A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2498604A1 (fr) * 2002-09-20 2004-04-01 Akzo Nobel N.V. Vaccin de parasite vivant attenue
CN115327099B (zh) * 2022-10-13 2022-12-30 苏州惠中生物科技有限公司 一种抗线粒体抗体m2的检测试剂盒
CN121320099B (zh) * 2025-12-12 2026-03-13 南方医科大学 一种弓形虫体外裂殖子诱导模型及其构建方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2149197A1 (fr) * 1994-06-17 1995-12-18 Irene Popiel Production d'un vaccin efficace contre la forme merozoite de toxoplasma gondii par culture cellulaire
WO1998003661A2 (fr) * 1996-07-19 1998-01-29 Arch Development Corporation Agents antimicrobiens, reactifs de diagnostic et vaccins a base de composants specifiques du parasite apicomplexan

Also Published As

Publication number Publication date
WO2000066154A3 (fr) 2001-03-15
EP1150709A2 (fr) 2001-11-07
AU4676000A (en) 2000-11-17
AU767117B2 (en) 2003-10-30
WO2000066154A2 (fr) 2000-11-09

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead