CA2379276C - Procede et dispositif de fermeture de capsules, et capsules destinees a ce procede et ce dispositif - Google Patents
Procede et dispositif de fermeture de capsules, et capsules destinees a ce procede et ce dispositif Download PDFInfo
- Publication number
- CA2379276C CA2379276C CA002379276A CA2379276A CA2379276C CA 2379276 C CA2379276 C CA 2379276C CA 002379276 A CA002379276 A CA 002379276A CA 2379276 A CA2379276 A CA 2379276A CA 2379276 C CA2379276 C CA 2379276C
- Authority
- CA
- Canada
- Prior art keywords
- capsule
- capsules
- gap
- sealing
- drying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 191
- 238000007789 sealing Methods 0.000 title claims abstract description 70
- 238000000034 method Methods 0.000 title claims abstract description 37
- 239000002904 solvent Substances 0.000 claims abstract description 81
- 238000001035 drying Methods 0.000 claims abstract description 62
- 239000007788 liquid Substances 0.000 claims abstract description 44
- 239000007887 hard shell capsule Substances 0.000 claims abstract description 5
- 239000007921 spray Substances 0.000 claims description 24
- 239000007787 solid Substances 0.000 claims description 2
- 230000001143 conditioned effect Effects 0.000 claims 1
- 238000013461 design Methods 0.000 description 20
- 239000000463 material Substances 0.000 description 18
- 239000012530 fluid Substances 0.000 description 15
- 230000009471 action Effects 0.000 description 11
- 230000008569 process Effects 0.000 description 9
- 230000007246 mechanism Effects 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 229910001220 stainless steel Inorganic materials 0.000 description 5
- 238000001816 cooling Methods 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 239000002699 waste material Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 239000007903 gelatin capsule Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 239000013557 residual solvent Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 230000007723 transport mechanism Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 238000012769 bulk production Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 230000008646 thermal stress Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Closing Of Containers (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention concerne un procédé de fermeture d'une capsule à enveloppe rigide comprenant des parties de corps coaxiales qui se superposent lorsqu'on les joint l'une à l'autre de manière télescopique, d'où la formation d'un espace autour de la capsule. Ledit procédé consiste à appliquer individuellement et uniformément un liquide d'étanchéité contenant un solvant sur le rebord externe de l'espace d'une capsule à fermer hermétiquement de manière à former un anneau liquide autour de la capsule, à extraire le liquide d'étanchéité excessif de l'extérieur de la capsule, puis à sécher ladite capsule par application d'une énergie thermique depuis l'extérieur tout en faisant tourner et circuler la capsule sur un chemin spiral.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99401949A EP1072245A1 (fr) | 1999-07-30 | 1999-07-30 | Procédé et appareil pour sceller des capsules et capsules aptes à être utilisées dans ce procédé et appareil |
| EP99401949.5 | 1999-07-30 | ||
| PCT/EP2000/006098 WO2001008631A1 (fr) | 1999-07-30 | 2000-06-30 | Procede et dispositif de fermeture de capsules, et capsules destinees a ce procede et ce dispositif |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2379276A1 CA2379276A1 (fr) | 2001-02-08 |
| CA2379276C true CA2379276C (fr) | 2008-09-30 |
Family
ID=8242076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002379276A Expired - Fee Related CA2379276C (fr) | 1999-07-30 | 2000-06-30 | Procede et dispositif de fermeture de capsules, et capsules destinees a ce procede et ce dispositif |
Country Status (12)
| Country | Link |
|---|---|
| EP (2) | EP1072245A1 (fr) |
| JP (1) | JP4684509B2 (fr) |
| KR (1) | KR100789431B1 (fr) |
| CN (1) | CN1213714C (fr) |
| AT (1) | ATE310487T1 (fr) |
| CA (1) | CA2379276C (fr) |
| DE (1) | DE60024272T2 (fr) |
| DK (1) | DK1202699T3 (fr) |
| EA (1) | EA003124B1 (fr) |
| ES (1) | ES2250152T3 (fr) |
| MX (1) | MXPA02001062A (fr) |
| WO (1) | WO2001008631A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1459725B1 (fr) | 2003-03-21 | 2007-10-17 | Warner-Lambert Company LLC | Dispositif et procédé pour sceller des gélules |
| US8377471B2 (en) * | 2005-08-09 | 2013-02-19 | Capsugel Belgium Nv | Container |
| EP1752140A1 (fr) * | 2005-08-12 | 2007-02-14 | Warner-Lambert Company LLC | Procédé de fermeture de capsules dures utilisant une composition à base d'hydroxypropylméthyl cellulose (HPMC) |
| EP1886657A1 (fr) * | 2006-08-11 | 2008-02-13 | Pfizer Products Inc. | Dispositif et méthode pour sceller des capsules |
| CA2666926C (fr) | 2006-10-24 | 2014-06-17 | Pfizer Products Inc. | Chaine de tranfert |
| CN106619128B (zh) * | 2015-11-04 | 2019-12-06 | 曹荣华 | 胶囊的封存组合物及其封存方法 |
| EP3219300B1 (fr) | 2016-03-15 | 2019-06-19 | Capsugel Belgium NV | Appareil de scellement de capsule dure aseptique et procédés |
| CN108451016B (zh) * | 2018-05-29 | 2021-01-29 | 云南中烟工业有限责任公司 | 一种预成型烟用包水爆珠的制备方法 |
| CN113647674B (zh) * | 2021-07-27 | 2023-08-29 | 常德市雄鹰科技有限责任公司 | 一种控制香烟爆珠大小的装置及方法 |
| CN113995677B (zh) * | 2021-11-23 | 2023-09-26 | 河北睿济堂中药股份有限公司 | 一种中药饮片润药机 |
| CN117860579B (zh) * | 2024-02-23 | 2026-03-17 | 武汉恺来科技有限公司 | 一种充液硬胶囊填充与密封方法及系统 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4823890B1 (fr) * | 1970-12-26 | 1973-07-17 | ||
| NL7803331A (nl) * | 1977-05-20 | 1978-11-22 | Capsugel Ag | Werkwijze voor het vervaardigen van een samengestelde capsule. |
| DE2722807A1 (de) * | 1977-05-20 | 1978-11-23 | Capsugel Ag | Verfahren zum herstellen einer mit viskosem stoff gefuellten steckkapsel |
| EP0116744A1 (fr) | 1982-12-20 | 1984-08-29 | Warner-Lambert Company | Dispositif et méthode pour sceller des capsules |
| US4656066A (en) * | 1982-12-20 | 1987-04-07 | Warner-Lambert Company | Apparatus and method for sealing capsules |
| US4539060A (en) | 1983-02-18 | 1985-09-03 | Warner-Lambert Company | Apparatus and method of sealing capsules |
| IE58468B1 (en) * | 1984-10-25 | 1993-09-22 | Warner Lambert Co | Method for sealing capsules and capsule |
| DE3543956A1 (de) * | 1985-12-12 | 1987-06-19 | Scherer R P Hartkapsel Gmbh | Zweiteilige steckkapsel und verfahren zum versiegeln einer solchen steckkapsel |
| US4734149A (en) * | 1987-03-20 | 1988-03-29 | Warner-Lambert Company | Apparatus for heatsealing gelatin capsules containing a medicament |
| US4724019A (en) * | 1987-03-20 | 1988-02-09 | Warner-Lambert Company | Method and apparatus for sealing capsules |
| JP2675142B2 (ja) * | 1989-06-12 | 1997-11-12 | 日本エランコ株式会社 | カプセルの封緘機 |
| JPH0765846B2 (ja) * | 1989-09-26 | 1995-07-19 | 日本エランコ株式会社 | 固型製剤乾燥装置 |
-
1999
- 1999-07-30 EP EP99401949A patent/EP1072245A1/fr not_active Withdrawn
-
2000
- 2000-06-30 CA CA002379276A patent/CA2379276C/fr not_active Expired - Fee Related
- 2000-06-30 EP EP00943950A patent/EP1202699B1/fr not_active Expired - Lifetime
- 2000-06-30 AT AT00943950T patent/ATE310487T1/de active
- 2000-06-30 WO PCT/EP2000/006098 patent/WO2001008631A1/fr not_active Ceased
- 2000-06-30 DK DK00943950T patent/DK1202699T3/da active
- 2000-06-30 CN CNB008110476A patent/CN1213714C/zh not_active Expired - Fee Related
- 2000-06-30 JP JP2001513364A patent/JP4684509B2/ja not_active Expired - Fee Related
- 2000-06-30 MX MXPA02001062A patent/MXPA02001062A/es active IP Right Grant
- 2000-06-30 DE DE60024272T patent/DE60024272T2/de not_active Expired - Lifetime
- 2000-06-30 KR KR1020027001347A patent/KR100789431B1/ko not_active Expired - Fee Related
- 2000-06-30 EA EA200200195A patent/EA003124B1/ru not_active IP Right Cessation
- 2000-06-30 ES ES00943950T patent/ES2250152T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02001062A (es) | 2003-04-10 |
| DE60024272T2 (de) | 2006-06-14 |
| EA200200195A1 (ru) | 2002-06-27 |
| CN1213714C (zh) | 2005-08-10 |
| JP4684509B2 (ja) | 2011-05-18 |
| EA003124B1 (ru) | 2003-02-27 |
| ES2250152T3 (es) | 2006-04-16 |
| DK1202699T3 (da) | 2006-04-03 |
| ATE310487T1 (de) | 2005-12-15 |
| CA2379276A1 (fr) | 2001-02-08 |
| WO2001008631A1 (fr) | 2001-02-08 |
| JP2003505204A (ja) | 2003-02-12 |
| EP1202699A1 (fr) | 2002-05-08 |
| CN1365268A (zh) | 2002-08-21 |
| EP1072245A1 (fr) | 2001-01-31 |
| DE60024272D1 (de) | 2005-12-29 |
| EP1202699B1 (fr) | 2005-11-23 |
| KR100789431B1 (ko) | 2007-12-28 |
| KR20020035844A (ko) | 2002-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150630 |