CA2391084A1 - High order nucleic acid based structures - Google Patents

High order nucleic acid based structures Download PDF

Info

Publication number: CA2391084A1
Authority: CA; Canada
Prior art keywords: nucleic acid; poly; molecules; structure according; molecule
Prior art date: 1999-11-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002391084A

Other languages

English (en)

French (fr)

Inventor

Frank J. Carr

Graham Carter

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Patent GmbH

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-13

Filing date

2000-11-13

Publication date

2001-05-25

1999-11-13 Priority claimed from GBGB9926810.4A external-priority patent/GB9926810D0/en

2000-05-10 Priority claimed from GB0011126A external-priority patent/GB0011126D0/en

2000-11-13 Application filed by Individual filed Critical Individual

2001-05-25 Publication of CA2391084A1 publication Critical patent/CA2391084A1/en

Status Abandoned legal-status Critical Current

Links

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PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 description 1
238000002255 vaccination Methods 0.000 description 1
239000003981 vehicle Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
- C12N2310/151—Nucleic acids forming more than 2 strands, e.g. TFOs more than 3 strands, e.g. tetrads, H-DNA
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/52—Physical structure branched

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Hematology (AREA)
Rheumatology (AREA)
Crystallography & Structural Chemistry (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

CA002391084A 1999-11-13 2000-11-13 High order nucleic acid based structures Abandoned CA2391084A1 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GB9926810.4		1999-11-13
GBGB9926810.4A GB9926810D0 (en)	1999-11-13	1999-11-13	High order nucleic acid-based structures
GB0011126.0		2000-05-10
GB0011126A GB0011126D0 (en)	2000-05-10	2000-05-10	High order nucleic acid-based structures
PCT/EP2000/011197 WO2001036624A1 (en)	1999-11-13	2000-11-13	High order nucleic acid based structures

Publications (1)

Publication Number	Publication Date
CA2391084A1 true CA2391084A1 (en)	2001-05-25

Family

ID=26244234

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002391084A Abandoned CA2391084A1 (en)	1999-11-13	2000-11-13	High order nucleic acid based structures

Country Status (16)

Country	Link
EP (1)	EP1228201A1 (cs)
JP (1)	JP2003522524A (cs)
KR (1)	KR20020059727A (cs)
CN (1)	CN1390253A (cs)
AU (1)	AU782880B2 (cs)
BR (1)	BR0015484A (cs)
CA (1)	CA2391084A1 (cs)
CZ (1)	CZ20021472A3 (cs)
HK (1)	HK1052529A1 (cs)
HU (1)	HUP0203914A2 (cs)
MX (1)	MXPA02004727A (cs)
NO (1)	NO20022231L (cs)
PL (1)	PL358811A1 (cs)
RU (1)	RU2002113755A (cs)
SK (1)	SK6042002A3 (cs)
WO (1)	WO2001036624A1 (cs)

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EP1141314A2 (en)	1998-12-31	2001-10-10	Chiron Corporation	Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
AU2002320314A1 (en)	2001-07-05	2003-01-21	Chiron, Corporation	Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
CN103889998A (zh) *	2011-08-05	2014-06-25	哈佛学院院长等	涉及核酸纳米和微米技术的组合物和方法
US10604543B2 (en)	2012-07-24	2020-03-31	President And Fellows Of Harvard College	Self-assembly of nucleic acid nanostructures
WO2014074597A1 (en)	2012-11-06	2014-05-15	President And Fellows Of Harvard College	Compositions and methods relating to complex nucleic acid nanostructures
US20160271268A1 (en) *	2013-11-08	2016-09-22	Dana-Farber Cancer Institute, Inc.	Nucleic acid nanostructures for in vivo agent delivery
TWI621584B (zh)	2014-05-22	2018-04-21	President And Fellows Of Harvard College	可縮放核酸奈米製造技術
EP3426598B1 (en)	2016-03-11	2021-07-28	Children's Medical Center Corporation	Nucleic acid nanoswitch catenanes
EP3494124B1 (en)	2016-08-02	2022-03-09	President and Fellows of Harvard College	Crisscross cooperative self-assembly
TWI743518B (zh) *	2018-07-12	2021-10-21	大陸商百藥智達（北京）納米生物技術有限公司	核酸奈米顆粒、包含其的藥物組合物、含阿霉素的藥物及其製備方法
CN110711254B (zh) *	2018-07-12	2022-07-26	百药智达（北京）纳米生物技术有限公司	核酸纳米颗粒及包含其的药物组合物
CN110960542B (zh) *	2018-09-30	2022-07-26	百药智达（北京）纳米生物技术有限公司	含吡柔比星的药物、其制备方法、药物组合物及其应用
CN110960536B (zh) *	2018-09-30	2022-07-26	百药智达（北京）纳米生物技术有限公司	含阿司匹林的药物、其制备方法、药物组合物及应用
CN110960530B (zh) *	2018-09-30	2022-07-22	百药智达（北京）纳米生物技术有限公司	含他克林的药物、其制备方法、药物组合物及其应用
CN110960690B (zh) *	2018-09-30	2022-07-22	百药智达（北京）纳米生物技术有限公司	含表柔比星的药物、其制备方法、药物组合物及其应用
CN110960534B (zh) *	2018-09-30	2022-07-26	百药智达（北京）纳米生物技术有限公司	含五氟尿嘧啶的药物、其制备方法、药物组合物及其应用
CN111053765B (zh) *	2018-10-16	2022-07-26	百药智达（北京）纳米生物技术有限公司	含紫杉醇的药物、其制备方法、药物组合物及应用
CN111068065B (zh) *	2018-10-22	2022-07-26	百药智达（北京）纳米生物技术有限公司	含奥沙利铂的药物、其制备方法、药物组合物及其应用
CN111084887B (zh) *	2018-10-23	2022-07-22	百药智达（北京）纳米生物技术有限公司	含黄酮的药物、其制备方法、药物组合物及应用
CN111096965B (zh) *	2018-10-29	2022-07-26	百药智达（北京）纳米生物技术有限公司	含双氢青蒿素的药物、其制备方法、药物组合物及其应用
WO2020210468A1 (en)	2019-04-10	2020-10-15	President And Fellows Of Harvard College	Nucleic acid nanostructures crosslinked with oligolysine
WO2020247724A1 (en)	2019-06-07	2020-12-10	Dana-Farber Cancer Institute, Inc.	Dna nanostructure-based vaccines

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EP0151631A1 (en) *	1983-08-03	1985-08-21	The Research Foundation Of State University Of New York	Nucleic acid branched junctions with precisely defined migrational mobility
US5386020A (en) *	1991-01-10	1995-01-31	New York University	Multiply connected, three-dimensional nucleic acid structures
US5278051A (en) *	1991-12-12	1994-01-11	New York University	Construction of geometrical objects from polynucleotides
US6072044A (en) *	1996-04-26	2000-06-06	New York University	Nanoconstructions of geometrical objects and lattices from antiparallel nucleic acid double crossover molecules

2000
- 2000-11-13 KR KR1020027006140A patent/KR20020059727A/ko not_active Withdrawn
- 2000-11-13 WO PCT/EP2000/011197 patent/WO2001036624A1/en not_active Ceased
- 2000-11-13 MX MXPA02004727A patent/MXPA02004727A/es unknown
- 2000-11-13 RU RU2002113755/04A patent/RU2002113755A/ru unknown
- 2000-11-13 AU AU20001/01A patent/AU782880B2/en not_active Ceased
- 2000-11-13 HU HU0203914A patent/HUP0203914A2/hu unknown
- 2000-11-13 BR BR0015484-9A patent/BR0015484A/pt not_active IP Right Cessation
- 2000-11-13 PL PL00358811A patent/PL358811A1/xx unknown
- 2000-11-13 JP JP2001538503A patent/JP2003522524A/ja active Pending
- 2000-11-13 CA CA002391084A patent/CA2391084A1/en not_active Abandoned
- 2000-11-13 HK HK03104743.9A patent/HK1052529A1/zh unknown
- 2000-11-13 CZ CZ20021472A patent/CZ20021472A3/cs unknown
- 2000-11-13 CN CN00815433A patent/CN1390253A/zh active Pending
- 2000-11-13 SK SK604-2002A patent/SK6042002A3/sk not_active Application Discontinuation
- 2000-11-13 EP EP00983130A patent/EP1228201A1/en not_active Withdrawn
2002
- 2002-05-10 NO NO20022231A patent/NO20022231L/no unknown

Also Published As

Publication number	Publication date
BR0015484A (pt)	2002-07-02
RU2002113755A (ru)	2004-01-10
JP2003522524A (ja)	2003-07-29
NO20022231D0 (no)	2002-05-10
NO20022231L (no)	2002-05-10
CN1390253A (zh)	2003-01-08
HK1052529A1 (zh)	2003-09-19
AU782880B2 (en)	2005-09-08
PL358811A1 (en)	2004-08-23
KR20020059727A (ko)	2002-07-13
MXPA02004727A (es)	2002-08-30
EP1228201A1 (en)	2002-08-07
AU2000101A (en)	2001-05-30
WO2001036624A1 (en)	2001-05-25
CZ20021472A3 (cs)	2002-07-17
SK6042002A3 (en)	2002-12-03
HUP0203914A2 (en)	2003-03-28

Legal Events

Date	Code	Title	Description
2006-11-14	FZDE	Discontinued

Publication	Publication Date	Title
AU782880B2 (en)	2005-09-08	High order nucleic acid based structures
Brown et al.	2024	Development of better aptamers: structured library approaches, selection methods, and chemical modifications
US8440811B2 (en)	2013-05-14	DNA nanostructures that promote cell-cell interaction and use thereof
AU2009200036B2 (en)	2012-07-26	Modulators of pharmacological agents
Ishikawa et al.	2013	RNA tectonics (tectoRNA) for RNA nanostructure design and its application in synthetic biology
US6180348B1 (en)	2001-01-30	Method of isolating target specific oligonucleotide ligands
US8552167B2 (en)	2013-10-08	Multifunctional aptamer-nucleic acid nanostructures for tumor-targeted killing
CN103403189B (zh)	2015-11-25	用于稳定的多价RNA纳米颗粒中的pRNA多价连接域
US20030027184A1 (en)	2003-02-06	Combinatorial selection of oligonucleotide aptamers
JP2006516151A (ja)	2006-06-22	改良された薬力学的特性を有する多価アプタマー治療剤ならびにそれらの作製方法および使用法
AU2002312059A1 (en)	2003-05-08	Modulators of pharmacological agents
WO1997041142A1 (en)	1997-11-06	Nanoconstructions of geometrical objects and lattices from antiparallel nucleic acid double crossover molecules
CN102459599A (zh)	2012-05-16	糖蛋白vi的核酸调节剂
Nakamura et al.	2012	RNA plasticity and selectivity applicable to therapeutics and novel biosensor development
Zavyalova et al.	2018	DNA aptamer-based molecular nanoconstructions and nanodevices for diagnostics and therapy
WO2005067437A2 (en)	2005-07-28	Methods and compositions for in vitro and in vivo use of parallel stranded hairpins and triplex structures as nucleic acid ligands
ZA200204728B (en)	2003-11-25	High order nucleic acid based structures.
JP7264487B2 (ja)	2023-04-25	キマーゼに対するアプタマー及びその使用
Gat et al.	1999	Template‐Directed Ligation: Towards the Synthesis of Sequence Specific Polymers
AU2012244176B8 (en)	2016-01-28	Modulators of pharmacological agents
AU2012244176B2 (en)	2015-09-17	Modulators of pharmacological agents
WO2020204151A1 (ja)	2020-10-08	Ｆｇｆ９に対するアプタマー及びその使用
Polisky	1998	Progress towards Therapeutic Application of SELEX-derived Aptamers
WO2005056794A2 (en)	2005-06-23	Agents for the regulation of transcription via zinc-finger proteins
Armitage	2001	10 Bioinspired organic chemistry