CA2398603A1 - Molecules du facteur 23 de croissance de fibroblastes et procedes d'utilisation correspondants - Google Patents
Molecules du facteur 23 de croissance de fibroblastes et procedes d'utilisation correspondants Download PDFInfo
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- CA2398603A1 CA2398603A1 CA002398603A CA2398603A CA2398603A1 CA 2398603 A1 CA2398603 A1 CA 2398603A1 CA 002398603 A CA002398603 A CA 002398603A CA 2398603 A CA2398603 A CA 2398603A CA 2398603 A1 CA2398603 A1 CA 2398603A1
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
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- Chemical & Material Sciences (AREA)
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Abstract
L'invention concerne des polypeptides du facteur 23 de croissance de fibroblastes et des molécules d'acides nucléiques les codant. L'invention concerne aussi des agents liants sélectifs, des vecteurs, des cellules hôtes et des procédés pour produire des polypeptides FGF-23. L'invention concerne aussi des compositions pharmaceutiques et des procédés pour le diagnostic, le traitement, l'amélioration et/ou la prévention de maladies, troubles et états associés aux polypeptides FGF-23.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18244200P | 2000-02-15 | 2000-02-15 | |
| US60/182,442 | 2000-02-15 | ||
| US19890300P | 2000-04-20 | 2000-04-20 | |
| US60/198,903 | 2000-04-20 | ||
| US74858101A | 2001-02-15 | 2001-02-15 | |
| US09/784,581 | 2001-02-15 | ||
| PCT/US2001/004778 WO2001061007A2 (fr) | 2000-02-15 | 2001-02-15 | Molecules du facteur 23 de croissance de fibroblastes et procedes d'utilisation correspondants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2398603A1 true CA2398603A1 (fr) | 2001-08-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002398603A Abandoned CA2398603A1 (fr) | 2000-02-15 | 2001-02-15 | Molecules du facteur 23 de croissance de fibroblastes et procedes d'utilisation correspondants |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1257645A2 (fr) |
| JP (1) | JP2005508131A (fr) |
| AU (1) | AU3976701A (fr) |
| CA (1) | CA2398603A1 (fr) |
| MX (1) | MXPA02007619A (fr) |
| WO (1) | WO2001061007A2 (fr) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001066595A2 (fr) * | 2000-03-08 | 2001-09-13 | Chiron Corporation | Gene humain fgf-23 et produits d'expression associes |
| AU2001245535A1 (en) * | 2000-03-08 | 2001-09-17 | Chiron Corporation | Human fgf-23 gene and gene expression products |
| JP2004504063A (ja) * | 2000-07-19 | 2004-02-12 | アドバンスド リサーチ ＆ テクノロジー インスティテュート | 新規線維芽細胞増殖因子（ｆｇｆ２３）および使用方法 |
| CN101275136A (zh) * | 2000-08-11 | 2008-10-01 | 麒麟医药株式会社 | 调节磷酸代谢,钙代谢,钙化和维生素d代谢的多肽及其编码dna |
| WO2002088358A2 (fr) * | 2001-04-26 | 2002-11-07 | Geneprot, Inc. | Compositions associees au facteur de croissance de fibroblastes humain |
| DE60329070D1 (de) * | 2001-12-28 | 2009-10-15 | Kyowa Hakko Kirin Co Ltd | Antikörper gegen den fibroblastenwachstumsfaktor 23 |
| US7094551B2 (en) | 2002-09-17 | 2006-08-22 | Zahradnik Richard J | Immunoassays, assay methods, antibodies and method of creating antibodies for detecting FGF-23 |
| US7883705B2 (en) | 2007-02-14 | 2011-02-08 | Kyowa Hakko Kirin Co., Ltd. | Anti FGF23 antibody and a pharmaceutical composition comprising the same |
| BRPI0911491A2 (pt) * | 2008-04-29 | 2016-01-05 | Novartis Ag | métodos de monitoramento da modulação de atividade de quinase de receptor de fator de crescimento de fibroblasto e usos dos ditos métodos. |
| US8951966B2 (en) | 2011-07-01 | 2015-02-10 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides, and uses and methods thereof for treatment of metabolic disorders and diseases |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| EP3798228A1 (fr) | 2012-11-28 | 2021-03-31 | NGM Biopharmaceuticals, Inc. | Compositions et procédés pour le traitement de troubles métaboliques et de maladies |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| MX383664B (es) | 2012-12-27 | 2025-03-14 | Ngm Biopharmaceuticals Inc | Uso de un péptido para modular la homeostasis de los ácidos biliares o tratamiento de una enfermedad relacionada con los ácidos biliares. |
| NZ718962A (en) | 2013-10-28 | 2019-12-20 | Ngm Biopharmaceuticals Inc | Cancer models and associated methods |
| RS60593B1 (sr) | 2014-01-24 | 2020-08-31 | Ngm Biopharmaceuticals Inc | Antitela koja vezuju domen 2 beta-kloto i postupci za njihovu upotrebu |
| US10398758B2 (en) | 2014-05-28 | 2019-09-03 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions |
| EP3155005A4 (fr) | 2014-06-16 | 2018-07-11 | NGM Biopharmaceuticals, Inc. | Procédés et utilisations pour la modulation de l'homéostasie de l'acide biliaire et le traitement de troubles et maladies de l'acide biliaire |
| SG11201702757YA (en) | 2014-10-23 | 2017-05-30 | Ngm Biopharmaceuticals Inc | Pharmaceutical compositions comprising peptide variants and methods of use thereof |
| US10434144B2 (en) | 2014-11-07 | 2019-10-08 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| CA2969307A1 (fr) | 2014-12-04 | 2016-06-09 | Novartis Ag | Procedes et compositions employant des polypeptides variants de klotho |
| US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
| JP6728352B2 (ja) | 2015-11-09 | 2020-07-22 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | 胆汁酸に関係した障害の治療方法 |
| US11370841B2 (en) | 2016-08-26 | 2022-06-28 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1032668B1 (fr) * | 1997-11-25 | 2008-05-28 | Genentech, Inc. | Facteur de croissance des fibroblastes 19 |
| WO2000060085A1 (fr) * | 1999-04-02 | 2000-10-12 | Millennium Pharmaceuticals, Inc. | Facteur de croissance 20 des fibroblastes |
| JP2004522402A (ja) * | 1999-06-02 | 2004-07-29 | ジェネンテック・インコーポレーテッド | 同一のものをコードする分泌及び膜貫通ポリペプチドと核酸 |
| EP1246843A1 (fr) * | 2000-01-05 | 2002-10-09 | ZymoGenetics, Inc. | Nouvel homologue du fgf, zfgf12 |
-
2001
- 2001-02-15 CA CA002398603A patent/CA2398603A1/fr not_active Abandoned
- 2001-02-15 JP JP2001560377A patent/JP2005508131A/ja not_active Withdrawn
- 2001-02-15 WO PCT/US2001/004778 patent/WO2001061007A2/fr not_active Ceased
- 2001-02-15 MX MXPA02007619A patent/MXPA02007619A/es unknown
- 2001-02-15 EP EP01914373A patent/EP1257645A2/fr not_active Withdrawn
- 2001-02-15 AU AU39767/01A patent/AU3976701A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001061007A3 (fr) | 2002-03-14 |
| WO2001061007A2 (fr) | 2001-08-23 |
| AU3976701A (en) | 2001-08-27 |
| EP1257645A2 (fr) | 2002-11-20 |
| JP2005508131A (ja) | 2005-03-31 |
| MXPA02007619A (es) | 2002-12-13 |
| WO2001061007A9 (fr) | 2002-04-18 |
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| FZDE | Dead |