CA2400915A1 - Variants de recepteurs oestrogeniques alpha et procede de detection desdits variants - Google Patents
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- CA2400915A1 CA2400915A1 CA002400915A CA2400915A CA2400915A1 CA 2400915 A1 CA2400915 A1 CA 2400915A1 CA 002400915 A CA002400915 A CA 002400915A CA 2400915 A CA2400915 A CA 2400915A CA 2400915 A1 CA2400915 A1 CA 2400915A1
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- 229960004622 raloxifene Drugs 0.000 description 1
- GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 description 1
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- 229940044601 receptor agonist Drugs 0.000 description 1
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- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000009863 secondary prevention Effects 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 238000009394 selective breeding Methods 0.000 description 1
- 238000002864 sequence alignment Methods 0.000 description 1
- 231100000004 severe toxicity Toxicity 0.000 description 1
- 239000013605 shuttle vector Substances 0.000 description 1
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- 239000010703 silicon Substances 0.000 description 1
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- 230000037439 somatic mutation Effects 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 102000005969 steroid hormone receptors Human genes 0.000 description 1
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- 230000000638 stimulation Effects 0.000 description 1
- 230000004960 subcellular localization Effects 0.000 description 1
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- 208000037369 susceptibility to malaria Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 230000005026 transcription initiation Effects 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000017105 transposition Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- 230000007306 turnover Effects 0.000 description 1
- 238000010798 ubiquitination Methods 0.000 description 1
- 230000034512 ubiquitination Effects 0.000 description 1
- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
- HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
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- 239000011701 zinc Substances 0.000 description 1
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- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- High Energy & Nuclear Physics (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention repose sur le séquençage d'ADN génomique du chromosome 6 humain et d'ADNc pour définir la structure génomique de gènes de récepteurs oestrogéniques alpha et de nouveaux polymorphismes/haplotypes dans le gène ou la protéine de récepteur oestrogénique. Ces polymorphismes/haplotypes peuvent conduire à toute une gamme de troubles qui sont induits/modulés par un récepteur oestrogénique variant, tels qu'une susceptibilité au cancer, à l'ostéoporose, aux maladies cardio-vasculaires, etc. Sur la base de cette approche par séquençage, la présente invention concerne des séquences nucléotidiques génomiques, des séquences d'ADNc, des séquences d'acides aminés et des polymorphismes de séquences/haplotypes dans les gènes de récepteur oestrogénique alpha, des méthodes de détection de ces séquences/polymorphismes/haplotypes dans un échantillon, des méthodes de détermination du risque pour un patient d'être atteint ou de développer un trouble induit par un récepteur oestrogénique variant et des méthodes de criblage de composés destinés à être utilisés pour traiter des troubles induits par un récepteur oestrogénique variant.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18375600P | 2000-02-22 | 2000-02-22 | |
| US60/183,756 | 2000-02-22 | ||
| US69241400A | 2000-10-20 | 2000-10-20 | |
| US09/692,414 | 2000-10-20 | ||
| US76818401A | 2001-01-24 | 2001-01-24 | |
| US09/768,184 | 2001-01-24 | ||
| PCT/US2001/005358 WO2001062969A2 (fr) | 2000-02-22 | 2001-02-20 | Variants de recepteurs oestrogeniques alpha et procede de detection desdits variants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2400915A1 true CA2400915A1 (fr) | 2001-08-30 |
Family
ID=27391734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002400915A Abandoned CA2400915A1 (fr) | 2000-02-22 | 2001-02-20 | Variants de recepteurs oestrogeniques alpha et procede de detection desdits variants |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1259650A2 (fr) |
| JP (1) | JP2004537959A (fr) |
| AU (1) | AU2001243196A1 (fr) |
| CA (1) | CA2400915A1 (fr) |
| WO (1) | WO2001062969A2 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6617162B2 (en) | 2001-12-18 | 2003-09-09 | Isis Pharmaceuticals, Inc. | Antisense modulation of estrogen receptor alpha expression |
| US20020123095A1 (en) * | 1999-10-20 | 2002-09-05 | Pe Corporation (Ny) | Estrogen receptor alpha variants and methods of detection thereof |
| US6897025B2 (en) * | 2002-01-07 | 2005-05-24 | Perlegen Sciences, Inc. | Genetic analysis systems and methods |
| ES2533002T3 (es) | 2004-03-10 | 2015-04-06 | Creighton University | Receptores estrogénicos y métodos de uso |
| JP6153526B2 (ja) | 2011-09-06 | 2017-06-28 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | ポリペプチドワクチン |
-
2001
- 2001-02-20 AU AU2001243196A patent/AU2001243196A1/en not_active Abandoned
- 2001-02-20 JP JP2001561777A patent/JP2004537959A/ja active Pending
- 2001-02-20 EP EP01916135A patent/EP1259650A2/fr not_active Withdrawn
- 2001-02-20 CA CA002400915A patent/CA2400915A1/fr not_active Abandoned
- 2001-02-20 WO PCT/US2001/005358 patent/WO2001062969A2/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1259650A2 (fr) | 2002-11-27 |
| WO2001062969A3 (fr) | 2002-03-14 |
| AU2001243196A1 (en) | 2001-09-03 |
| WO2001062969A2 (fr) | 2001-08-30 |
| JP2004537959A (ja) | 2004-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |