KR20180093902A - 태아와 임신 여성간에 상이하게 메틸화된 디엔에이 영역을 이용한 태아 염색체 이수성의 검출 - Google Patents

태아와 임신 여성간에 상이하게 메틸화된 디엔에이 영역을 이용한 태아 염색체 이수성의 검출 Download PDF

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KR20180093902A
KR20180093902A KR1020187015371A KR20187015371A KR20180093902A KR 20180093902 A KR20180093902 A KR 20180093902A KR 1020187015371 A KR1020187015371 A KR 1020187015371A KR 20187015371 A KR20187015371 A KR 20187015371A KR 20180093902 A KR20180093902 A KR 20180093902A
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스테피 웨러
웨라 호프만
마티아스 사체스
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Abstract

본 발명은 임신여성이 수태한 태아의 염색체 이수성을 검출하는 방법에 관한 것이다. 이 방법은 한 가지 이상의 특정 구성에 기반하며, 그리고/또는 태아의 세포(및/또는 태아의 태반)로부터 유래된 DNA와 모체 유래 DNA 간에 상이하게 메틸화된(differentially methylated) 둘 이상의 DNA 영역의 검출 및/또는 분석에 기반한다. 이 방법은 임신여성으로부터 채취한 시료를 이용하는데, 이 시료에는 상이하게 메틸화되는 모체 유래 DNA와 혼합된 태아 세포 및/또는 태아 태반 유래 DNA가 포함된다. 이 방법은, 특히, 태아에서의 염색체 이수성(예를 들어, 삼염색체)의 검출/진단을 위한 그리고/또는 임신관련 의학적 증상을 앓거나 발병할 임신여성의 위험 증가를 검출하기 위한 진단적, 예후적, 및/또는 예측적 유용성을 갖는다. 본 발명은 또한, 이러한 방법의 실시에 사용되거나 유용하거나 관련될 수 있는 조성물, 키트, 컴퓨터 프로그램 제품, 및 기타 양태에도 관계된다.

Description

태아와 임신여성 간에 상이하게 메틸화된 디엔에이 영역을 이용한 태아 염색체 이수성의 검출
[1] 본 발명은 임신여성이 수태한 태아의 염색체 이수성을 검출하는 방법에 관한 것이다. 이 방법은 한 가지 이상의 특정적인 구성에 기반하며, 그리고/또는 태아의 세포(및/또는 태아의 태반)로부터 유래된 DNA와 모체 유래 DNA 간에 상이하게 메틸화된(differentially methylated) 둘 이상의 DNA 영역의 검출 및/또는 분석에 기반한다. 이 방법은 임신여성으로부터 채취한 시료를 이용하는데, 이 시료에는 상이하게 메틸화되는 모체 유래 DNA와 혼합된 태아 세포 및/또는 태아 태반 유래 DNA가 포함된다. 이 방법은, 특히, 태아에서의 염색체 이수성(예를 들어, 삼염색체)의 검출/진단을 위한 그리고/또는 임신관련 의학적 증상을 앓거나 발병할 임신여성의 위험 증가를 감지하기 위한 진단적, 예후적, 및/또는 예측적 유용성을 갖는다. 본 발명은 또한, 이러한 방법의 실시에 사용되거나 유용하거나 관련될 수 있는 조성물, 키트, 컴퓨터 프로그램 제품, 및 기타 양태에도 관계된다.
[2] 대부분의 선진국에서는 많은 임신여성들이 출산전 태아 검사를 받는데, 그 주된 목적은 발달중인 태아의 염색체 이수성(chromosomal aneuploidy)을 확인하기 위한 것이다. 최근까지 대부분의 신뢰할만한 태아 검사는 융모막 융모시료 채취(chorionic villus sampling, CVS) 또는 양수천자(amniocentesis)와 같은 침습적이었고, 97.% 내지 99.8%로 보고된 검사 정확도에도 불구하고 시술에 관련하여 유산의 위험은 그리 크지 않았다(Norwitz & Levy 2013, Rev Obs Gyn 6:48 참조). 태아 염색체 이수성에 대한 종래의 비침습적 태아 검사에는, 초음파 및/또는 다양한 모체 혈청 생화학 마커 분석법을 이용한 걸러내기(screening)가 포함된다. 그런데 이들 검사들은 주로 다운증후군(21번 삼염색체(trisomy chromosome 21(T21). 그리고 더 적은 양의 T18)의 검출을 목적으로 한다. 그러나 단지 75~96%의 검출율(사용된 걸러내기 기법에 따라 상이함)과 5%~10%의 거짓양성 비율로 인해, 상기 초음파 및 모체 혈청 분석법은 단지 걸러내기 절차로만 고려되고 있으며, 이들 두 경우에 모두 태아의 염색체 이상의 확진을 위해서는 영상상 양성의 경우에도 CVS 또는 양수천자를 이용한 추적 관찰이 필요하다(Norwitz & Levy, 2013).
[3] 태아로부터 온(유래한) 무세포 DNA(cell-free DNA:cfDNA)가 모체 순환계(materal circulation)에서 발견됨에 따라(Lo 외 1997, Lancet 350:485), 비침습적 출산전 검사(NIPT: non-invasive prenatal testing) 방법의 개발을 위한 대안적 접근법이 제시되었다. 이 접근법에는 태아의 성 판별(Lo 외 1997), 그리고 모체가 Rh D(Rhesus D) 음성인 임신중 태아의 Rh D 테스트(Lo 1998, N Eng J Med 229:1734)가 포함된다. 그러나 이러한 태아의 cfDNA는 모체 혈장으로부터 분리된 총 cfDNA 내에 적은 비율로만 존재하기 때문에(Lo 외 1998, Am J Hum Genet 63:768), 모체 혈장로부터의 태아 cfDNA에 기반하여 태아 염색체 이수성을 검출하는 것에는 어려움이 있다. 높은 처리율의 차세대 시퀀싱(NGS: next generation sequencing) 기술을 적용하여 모체 혈장의 cfDNA에 대한 태아 및 모체의 기여분 모두를 시퀀싱하는 것이 가능하게 되었으며, 최근 몇 년 동안에만도 21번 염색체 및 그 밖에 임신여성에게 일상적인 통상의 태아 이수성에 대한 NGS 기반의 NIPT의 실시가 가능해져, 예컨대 상업적 검사법이 출현하고 일반적인 이용이 가능해졌다. 상업적으로 이용가능한 검사에서는 'MATERNIT21' (www.sequenom.com), 'PRENATEST' (www.lifecodexx.com), 'VERIFI' (www.illumina.com), 'IONA' (www.premaitha.con)와 같은 NGS 기법을 임의로 사용할 수 있다. 또는, 신뢰성있는 통계 분석(예를 들어, 'HARMONY' www.ariosadx.com 또는 'PANORAMA' www.natera.com), 다형성 분석, 또는 디지털 PCR(Go 외 2011, Human Reprod Update 17:372 참조)을 수행하는 데 필요한 서열 태그의 수를 줄이기 위해 시퀀싱 수행 전에 특정 관심 게놈 영역을 농축(enrich) 하는 것을 목적으로 하는 표적 접근법(targeted approach)을 사용할 수도 있다.
[4] 현재까지, 시퀀싱 기법을 따르는 상술한 상업적 NIPT는 대용량 병렬처리 시퀀싱장치 등 복잡하고 매우 고가의 장비의 사용을 필요로 하며, 수 일 내지 10일의 처리기간이 소요되고 분석 전에 상당한 양의 시료 처리가 필요하다. 예를 들어, NGS를 이용한 태아 이수성 NIPT는, 분리된 cfDNA의 각 개별 단편들로 대량의 소위 '시퀀싱 라이브러리(sequencing library)'를 구성하는 시간 및 비용 소모적 단계를 필요로 한다. 디지털 PCR을 따르는 대안적 NIPT도 있지만, 이는 일반적으로 매우 전문화되고 현지화된 연구실 이외의 곳에서는 사용가능하지 않은 장비와 기술을 사용해야 하며 처리율이 비교적 낮다(Hindson 외 2011, Anal Chem 83:8604).
[5] NIPT의 cfDNA에 대한 중대한 한계를 인식하여, 태아 이수성의 검사를 위한 NIPT 실시에 대하여 특히 저렴하고 신속한 대안을 연구 및 개발하고자 하는 많은 시도가 있었다. NIPT에 대한 이러한 대안들 중에서 다수는 모체 혈장에서 발견되는 태아 DNA의 태아특이적 특성(foetal-specific characteristics)(예를 들어, 태아 cfDNA의 특정 종들(species) 또는 태아 cfDNA에 있어서의 다형성(polymorphism))의 이용에 집중하고 있다. 특히, 모체 DNA와 비교하여 태아 DNA에서 특이적으로 메틸화된(methylated) DNA 영역의 존재에 의해, 관심대상 태아 염색체의 NIPT를 위한 상기 후성유전적 마커(epigenetic marker)의 사용에 상당한 노력을 경주하게 되었다.
[6] 임신여성의 혈장에서 태아 DNA를 특이적으로 식별하기 위한 후성유전적 마커의 사용에 대한 최초의 시연(데모)은 2002년에 이루어졌다(Poon 외 2002, Clin CHem 48:35; WO 2003/020974). 그러나 이때 사용된 마커의 유용성은 그것이 다형성 의존적(polymorphic-dependent)이었기 때문에 특정 태아-모체 쌍에만 제한되었다. 보다 범용으로 적용가능한 태아특이적 후성유전적 마커는, 후보 유전자 기법에 이어서 2005년에 알려진 'serpin peptidase inhibitor clade B member 5'(다른 말로, maspin) 유전자('U-maspin' 또는 'U-SERPINB5')의 메틸화된 형태이었다(Chim 외 2005, PNAS 102:14753). 이 maspin 유전자는 인간의 18번 염색체에 위치하며, 그 원리는 상기 후성유전적 마커를 사용하여 태아의 18번 삼염색체(trisomy 18)의 비침습적 식별을 수행할 수 있는 것임을 최초로 밝혔다(Tong 외 2006, Clin Chem 52:2194, WO 2005/118852).
[7] 이러한 원리에 따른 시연을 통해, 또다른 태아 후성유전적 마커, 특히, 21번 염색체와 같이 태아 이수성에 관련된 염색체를 위한 후성유전적 마커를 찾기 위하여 다수의 그룹이 출범하였다(예를 들어, Old 외 2007, Reprod Biomed Online; Chim at al 2008, Clin Chem 54:500; Papageorgiou 외 2009. Am J.Pathol 174:1609; WO 2007/132166; WO 2007/132167; WO 2011/034631; 및 WO 2011/092592). 이들의 목표는, 다른 상염색체 또는 성염색체에서 유래한 기준 서열 대비, 후성유전적으로 식별된 태아 cfDNA 내의 21번 염색체에서 유래한 서열을 정량화함으로써 태아 이수성의 NIPT를 위해 후성유전적 마커를 이용하려는 것이었다(예를 들어, Old 외 2007).
[8] 이러한 후성유전적 마커들 중 일부가 NIPT용 툴로서 연구되었다. 실제로, 포스포디에스테라아제(phosphodiesterase) 9A 유전자(U-PDE9A)의 메틸화되지 않은 형태가 태아의 21번 삼염색체 검사용 NIPT에 이용되었다(Lim 외 2011, PLoS One 6:e27709). 또다른 연구에서는, 유전자 Y 상에서의 태아 유전학적 마커인 징크핑거 단백질(zinc finger protein) Y-Linked(ZFY) 유전자의 농도 대비, 정규화된 상대 염색체 21의 용량을 비교하기 위하여 홀로카르복실라제 신세타제(holocarboxylase synthetase) 유전자(M-HLCS)의 메틸화된 형태가 태아 후성유전적 마커로서 사용되었다. 이 후성유전적/유전적('EGG') 접근법이 태아의 21번 삼염색체의 비침습적 검출에 유용하다는 것이 입증되었다(Tong 외 2010, Clin Chem 56:90). 다른 접근법을 이용하여, Papageorgiou와 그 동료들은 전체 혈액에서 얻은 모체 DNA와 비교하여 태아 특이적인 상이하게 메틸화된 영역(DMR: differentially methylated regioin)의 21번 염색체의 상대적 양을 정량화하기 위하여 면역 침전(immunoprecipitation) 및 실시간 정량적 폴리머라제 연쇄 반응(qPCR: quantitative polymerase chain reaction) 기법의 이용을 설명하여, 삼염색체의 경우에 있어서 21번 염색체가 약간 과도함을 검출할 수 있어 태아의 21번 삼염색체의 진단이 가능함을 주장하였고(Papageorgiou 외 2011, Nat Med 17:510), 단일 DMR이 아닌 DMR들의 조합으로 정상 사례 및 21번 삼염색체 사례의 정확한 NIPD 결과를 얻을 수 있다는 가설을 하였다. 그 이후의 연구에서, 이보다 큰 규모의 블라인드 검증 연구에서 상기 접근법이 100%의 감도(sensitivity)와 99.2%의 특정도(specificity)를 나타냈다는 보고가 있었다(Tsaliki 외 2012, Prenat Diag 21:996). 상기 접근법은 다루기 힘들고 기술적으로 어려운 메틸화된 DNA의 면역 침전(MeDiP) 단계를 필요로 할뿐만 아니라 이 접근법을 이용하는 것에 대한 심각한 기술적 우려가 제기되었다(Tong 외 2012, Nat Med 18:1327). 구체적으로, 이 접근법을 이용하여, 다량의 무세포 태아 DNA 또는 다수의 태아 세포를 모체 혈액 속으로 방출하게 되는 정배수체(euploid) 태아에 비하여 모체 혈액에서 염색체 21 마커의 태아 유래 DNA 메틸화의 양이 증가하는 것은 21번 삼염색체를 갖는 태아의 존재때문이다라는 결론을 내리는 것은 가능하지 않다는 것이다. MeDiP 기법에 대한 논평에서 Tong과 동료들은 염색체 21 외부의 태아 후성유전적 마커를 사용하여 태아 DNA 농도의 변화를 조절하기 위하여 정규화(normalisation) 단계를 포함시킬 수 있으나, 이는 RASSF1, 즉, 염색체 3번 상의 유전자를 이용한 그 전 연구에서, 이러한 정규화의 효과는 대부분 태아 DNA를 포함하고 있는 태반 조직의 경우에서조차도 EGG 기법에 비해 차선적이라는 것으로 나타났다고 제시하였다(Tong 외 2010).
[9] 그러나 모체 프라이머(maternal primer)로부터의 메틸화된 DNA를 농축하는 단계부터 시작하는 최근의 연구에서, Lim과 동료들은 기준 염색체인 3번 염색체(M-RASSF1A) 대비, 21번 염색체의 상대적 용량을 측정하기 위해 (M-HLCS를 사용하는) 기존의 qPCR 법을 사용하였고, 태아의 21번 삼염색체의 비침습적 출산전 검출(NIPD)에서 90%의 감도와 92.5%의 특정도를 보고했다(Lim 외 2014, Clin Chem Lab Med 52:641). Tong과 동료들이 보고한 초기 연구(Tong 외 2010)에서의 일견 개선에도 불구하고 Lim의 접근법에는 개선의 여지가 있다는 보고가 있었다(Chim 2014, Clin Chem Lab Med 52:585). 실제로 Chim은 태아의 21번 삼염색체의 NIPT를 위해 태아 후성유전적 마커를 사용하는 성과를 향상시키는 방법을 모색하기 위해 Lim과 유사한 별도 연구의 두드러진 특징을 정리했다(표 A 참조, 출처: Chim 2014)
표 A: 태아 후성유전적 마커를 이용한 21번 삼염색체의 비침습적 태아 검사에 관한 연구 (출처: Chim 2014)
Figure pct00001
[10] Chim은 다음과 같이 요약했다 ― (1) 디지털 PCR은 기존의 양적 측정과 비교하여 더 나은 감도와 특정도를 제공하며, qPCR의 지수함수적이지만 아날로그적인 성질을 디지털 PCR, 즉, 디지털 계수 플랫폼에서 '1' 또는 '0' 신호로 변환하는 것이 더 정밀하고 정확한 정량화일 것으로 보여진다, (2) 태아 유전적 마커(genetic marker)의 사용이, 상대적 염색체 양 분석을 위한 기준 염색체를 정량화하는 데 있어서 태아 후성유전적 마커보다도 감도와 특정도가 더 나은 것으로 보여진다. 사실상, Tong과 동료들이 유사후성유전적/후성유전적 접근법과 비교되는 EGG 기법의 비교연구(2010)에서 얻은 결과 발표와 유사하게, Chim은 태아 후성유전적 마커, 즉 3번 염색체에 위치하는 M-RASSF1A에 대한 정규화를 통해 Tong과 그의 동료들이 21번 삼염색체에 대한 태반 연구의 절반보다 많은 21번 염색체의 상대량이 정배수체(euploid)의 (정상적인) 기준 간격과 중첩되어 25%의 무용한 감도를 초래한다는 것을 발견했다고 기술하였다(표 B 참조).
표 B: Tong 외(2010)의 태아의 후성유전적 또는 유전적 마커를 기준으로 사용한 21번 삼염색체의 출산전 검사 데이터(출처: Chim 2014)
Figure pct00002
[11] 따라서 태아 이수성 NIPT 검사의 개선 필요성이 오랫동안 있음에도 불구하고 그리고 이를 위한 2002년 이후의 태아 특이적 후성유전적 마커를 사용하는 이론적인 가능성에도 불구하고, 현재까지 만족스럽고 신뢰성있고 감도 및 특정도가 높으며 비용효율적인 그리고/또는 기술적으로 직관적인 방법은 없었다. 사실, Chim은 자신의 최근의 연구에서조차도, 여전히 개선의 필요성이 있다고 주장하면서 디지털 PCR 플랫폼의 사용, 그리고 태아 유전적 마커를 이용한 정규화만이 상기 후성유전 기반 검사의 성능을 더 향상시킬 것이라고 결론지었다. 그러나 디지털 PCR 접근법은, 매우 전문화되고 현지화된 연구 실험실을 제외하고 일반적으로는 이용가능성이 없는 기술적 어려움이 있는 장치의 사용을 필요로 하며, 태아 유전적 마커(즉, 모체 게놈과 유전적으로 다른 마커)를 사용하는 것은 상기 검사법의 적용처를, 유전적 차이가 존재하는 특정 태아-모친 쌍에 대해서만 국한시키며(예를 들어 수컷 포유동물과 ZFY의 유전적 마커로서의 사용), 그러한 유전적 차이를 알기 위한 추가적인 성별 또는 유전자 검사가 이루어진 후에야 태아 이수성 NIPT 검사를 분석할 수 있게 된다.
[12] 이에, 상술한 것과 같이 또는 향후 전망을 볼 때, 비침습적이고 그리고/또는 더 일반적인 처리, 기술, 및/또는 검출 단계/장비를 사용하여 태아 내의 염색체 이수성의 존재를 더 빠르고 비용효율적으로 그리고/또는 더 광범위하게 수행할 수 있는 검출, 지시, 또는 진단 방법 및 이에 관련된 여러 양태들을 개선해야 할 필요성이 있다.
[13] 따라서, 본 발명의 목적은 상술한 또는 다른 문제점들 중 하나 이상을 처리하는 대안적이고 개선된 그리고 더 단순하고 저렴한 그리고/또는 통합된 수단 또는 방법을 제공하는 것이다. 본 발명의 근간을 이루는 이러한 목적은 본 명세서에 개시되거나 정의된 것과 같은 발명 주제, 예를 들어 첨부된 특허청구범위의 발명 주제에 의해 해결된다.
[14] 전반적으로 간단히 기술하면 본 발명의 주된 양태는 다음과 같다.
[15] 제1양태에 있어서, 그리고 이하에서 자세하게 기술하고 정의하였으며 특허청구하거나 그 밖에 개시한 바와 같이, 본 발명은 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법을 제공한다. 이 방법은,
(a) 모체에서 유래한 상이하게 메틸화된 DNA와 혼합된, 태아의 세포 및/또는 태아의 태반으로부터 유래된 DNA가 포함된, 상기 임신여성으로부터 채취한 시료를 제공하는 단계;
(b) 메틸화 및 비메틸화 DNA를 상이하게 변형시키는 시약으로 상기 시료에 존재하는 DNA를 처리하는 단계;
(c) 상기 시료에서 염색체 이수성과 관련된 염색체인 제1 표적 DNA 종의 양을 결정하되, 상기 염색체에 위치하는 둘 이상의 제1 표적의 상이한 메틸화 영역(제1 표적 DMR)에 메틸화가 존재하는지를 상기 시료에서 검출함으로써 결정하는 단계; ― 여기서, 상기 제1 표적 DMR은 태아의 세포 및/또는 태아의 태반에서 유래한 DNA와 모체 유래 DNA 간에 상이하게 메틸화된 영역이고, 제1 표적 DMR의 DNA의 상기 시약에 의한 변형은 DNA의 메틸화에 감응하고, 상기 제1 표적 DMR 중 하나 이상에서의 메틸화 DNA의 검출량은 상기 시료 내의 상기 제1 표적 DNA 종의 양을 나타낸다.
(d) 상기 시료에서 하나 이상의 기준 염색체인 기준 DNA 종의 양을 결정하되, 상기 기준 염색체(들)에 위치하는 둘 이상의 기준 DMR에 메틸화가 존재하는지를 상기 시료에서 검출함으로써 결정하는 단계; ― 여기서, 상기 기준 DMR은 태아의 세포 및/또는 태아의 태반에서 유래한 DNA와 모체 유래 DNA 간에 상이하게 메틸화된 영역이고, 상기 기준 DMR의 DNA의 상기 시약에 의한 변형은 DNA의 메틸화에 감응하고, 상기 기준 DMR 중 하나 이상에서의 메틸화 DNA의 검출량은 상기 시료 내의 상기 기준 DNA 종의 양을 나타낸다.
(e) 단계 (c)에서 결정된 양과 단계 (d)에서 결정된 양의 상대적 양(들), 바람직하게는 비율(들)을 결정하는 단계 ― 여기서, 상기 하나 이상의 상대적 양(들)은 태아 내의 염색체 이수성의 존재 또는 부존재를 지시한다 ― 를 포함한다.
이때, 상기 단계 (c) 및 단계 (d)에서의 상기 검출은 상기 시료의 동일한 DNA 분취량(aliquot)을 사용하여, 그리고 동일 용기에서, 그리고 상기 제1 표적 DMR 및 상기 기준 DMR에 대해 유효하게 동시에 수행되며, 그리고 (x) 상기 기준 DMR의 적어도 두 개에 대해 동일한 검출 표지(들)를 사용하여서 그리고/또는 (y) 상기 제1 표적 DMR의 적어도 두 개에 대해 상이한 검출 표지(들)를 사용하여서 수행된다.
[16] 제2양태에 있어서, 그리고 이하에서 자세하게 기술하고 정의하였으며 특허청구하거나 그 밖에 개시한 바와 같이, 본 발명은 임신여성이 임신관련 의학적 증상을 앓고 있는 또는 발병할 위험의 증가를 감지하는 방법을 제공한다. 이 방법은
(i) 제1양태의 방법(아래의 단계 (f)를 추가로 포함함)을 수행하는 단계 ― 단, 제1양태의 방법에, (f) 상기 시료에서 총 DNA의 양을 결정하되, 태아의 세포 및/또는 태아의 태반으로부터 유래한 DNA와 모체 유래 DNA 간에 상이하게 메틸화되지 않은 적어도 하나의 타영역(OR)을 검출함으로써 결정(여기서 상기 시약에 의한 OR(들)의 변형은 DNA 메틸화에 감응성이 없음)하는 단계 ― 여기서 상기 단계 (c) 및 단계 (d) 및 단계 (f)에서의 상기 검출은 상기 시료의 동일한 분취량의 DNA를 사용하여 그리고 동일한 용기에서, 그리고 효율적으로는 상기 기준 DMR 및 상기 타영역에 대하여 동시에 이루어지며, 그리고 (x) 상기 기준 DMR의 적어도 2개 이상에 대해 동일한 검출 표지(들)가 사용되고, (y) 상기 제1 표적 DMR의 적어도 두 개에 대해 그리고 상기 OR의 적어도 하나에 대해 상이한 검출 표지(들)가 사용됨 ― 가 추가로 포함됨;
(ii) 시료에 존재하는 태아 DNA의 적어도 하나의 양, 특히, 절대적 양 또는 상대적 양을 결정하는 단계; 그리고
(ⅲ) 결정된 태아 DNA의 양을 임계값 및/또는 기준 분포와 비교하는 단계 ― 여기서 상기 임계값 및/또는 기준 분포로부터 상기 태아 DNA의 양이 증가 또는 이탈하는 것은 임신여성이 상기 임신관련 의학적 증상을 앓고 있는 또는 발병할 위험이 증가하는 것을 지시함 ― 를 포함한다.
[17] 그 밖의 양태로서, 본 발명은 또한 조성물, 키트(또는 그 구성품), 및 컴퓨터 프로그램 제품을 제공한다. 이들은 이하에서 자세하게 기술하고 정의하였으며 특허청구하거나 그 밖에 개시한 바와 같고, 이러한 양태들은 본 발명 방법과 연관되거나 유용할 수 있으며, 본 발명 방법의 범위 내에서 또는 연계하여 사용 가능하다.
본 발명에 따르면, 태아에서의 염색체 이수성(예를 들어, 삼염색체)의 검출/진단 뿐만 아니라, 임신관련 의학적 증상을 앓거나 발병할 임신여성의 위험 증가의 감지도 가능한 진단적, 예후적, 및/또는 예측적 유용성을 갖는다. 본 발명은 비침습적이고 더 일반적인 처리, 기술, 및/또는 검출 단계/장비를 사용하여 태아 내의 염색체 이수성의 존재를 더 빠르고 비용효율적으로 그리고 더 광범위하게 수행할 수 있어서, 종래의 방법에 대한 대안이 되며 개선된 그리고 더 단순하고 저렴한 그리고/또는 통합된 방법을 제공한다.
[19] 도 1의 (a)는 제1 메틸화 기반 DNA 검출 방법에 이용되는 상이한 메틸화 영역(들)(DMR) 및 타영역(들)(OR)의 개략도, (b)는 제2 메틸화 기반 DNA 검출 방법에 이용되는 상이한 메틸화 영역(들)(DMR) 및 타영역(들)(OR)의 개략도이다.
[20] 도 2는 실시예 1에 이용된 상이한 메틸화 영역(DMR) 및 타영역(OR)의 개략도이다.
[21] 도 3은 알고 있는 성별의 쌍태아 연구를 위하여 상이한 메틸화 기반 DNA 검출 방법(실시예 1)에 의해 측정된 태아분 cfDNA 대비, 남성 특이적 DNA 양의 상관 관계(Y 염색체 재현)를 나타낸다.
[22] 도 4는 단일 DMR의 개별적 반응을 통해 검출된 기준 염색체 검출 감도에 비해, 다중형의 상이한 메틸화 기반 DNA 검출 방법 사용시에 기준 염색체의 검출 감도가 향상됨을 나타낸다. Cp는, RASSF1A나 TBX3를 단독으로 단일 DMR로서 사용하거나 RASSF1A 및 TBX3의 다중혼합물(동일한 표지를 사용)을 사용하여 시료 내의 기준 염색체에서 도출된 태아 cfDNA의 검출(실시예 2)에 필요한 PCR 사이클 수를 나타낸다.
[23] 도 5는 실시예 3의 컴퓨터 프로그램 제품에 의해 수행되는 연산의 개략도이다.
[24] 도 6은 본 발명 방법으로 실시예 4에서 이용된 상이한 메틸화 영역(DMR)(및 선택적으로 이용되는 타영역(OR))의 개략도이다.
[25] 도 7은 59개 시료의 첫 번째 검사시의 각 시료에 대하여, 기준 염색체(5번 및 12번)의 양에 대한 21번 염색체의 양(21번 염색체에 위치하는 하나의 표적 DMR에 의해 결정됨)의 비율[x축]과, 기준 염색체의 양에 대한 21번 염색체의 양(21번 염색체에 위치한 다른 표적 DMR에 의해 결정됨)의 비율[y축]을 나타내는 산포도이다(여기서 상기 양들은 실시예 4에 기재된 발명 방법에 의해 결정됨). 21번 삼염색체(T21)를 갖는 태아를 수태한 여성을 나타내는 포인트는 '+'로 표시되어 있으며, 이들은 Non-T21 시료들과 구별된다.
[26] 도 8은 총 168개 시료에 대한 총 3회의 검사 실행시의 각 시료에 대하여, 기준 염색체(5번 및 12번)의 양에 대한 21번 염색체의 양(21번 염색체에 위치하는 하나의 표적 DMR에 의해 결정됨)의 정규화된 비율[x축]과, 기준 염색체의 양에 대한 21번 염색체의 양(21번 염색체에 위치한 다른 표적 DMR에 의해 결정됨)의 정규화된 비율을 나타내는 산포도이다(여기서 상기 양들은 실시예 4에 기재된 발명 방법에 의해 결정됨). 21번 삼염색체(T21)를 갖는 태아를 수태한 여성을 나타내는 포인트는 '+'로 표시되어 있으며, 이들은 Non-T21 시료들과 구별되도록 무리지어 있다. 예를 들어, 점선 경계선으로 구획되어 있다. 실시예 4에 언급된 이탈값들인 Non-T21 시료가 x축의 해당 영역 밖에 위치함(T21 무리 안에는 없음)을 주목하라.
[27] 도 9는 도 8의 각 포인트를 구획하는 곡선 구획선의 중심점(0.5,0.55)으로부터의 거리를 검사 실행 횟수에 대해 나타낸 산포도이다. Non-T21 시료(이 그림에서 '+'로 표시)와 9개의 T21 시료(이 그림에서 'o'로 표시) 사이에, 모든 실행에 걸쳐서 명확한 구별이 있음을 나타내고 있다.
[28] 도 10은 총 168개 시료에 대한 총 3회의 검사 실행시의 각 시료에 대하여, 기준 염색체(5번 및 12번)의 양에 대한 21번 염색체의 양(21번 염색체에 위치하는 하나의 표적 DMR에 의해 결정됨)의 비율의 z스코어[x축]와, 기준 염색체의 양에 대한 21번 염색체의 양(21번 염색체에 위치한 다른 표적 DMR에 의해 결정됨)의 비율의 z스코어[y축]를 나타내는 산포도이다(여기서 상기 양들은 실시예 4에 기재된 발명 방법에 의해 결정됨). 21번 삼염색체(T21)를 갖는 태아를 수태한 여성을 나타내는 포인트는 '+'로 표시되어 있으며, 이들은 Non-T21 시료들과 구별되도록 무리지어 있다. 예를 들어, 점선 경계선으로 구획되어 있다. 실시예 4에 언급된 이탈값들인 Non-T21 시료가 x축의 해당 영역 밖에 위치함(T21 무리 안에는 없음)을 주목하라.
[29] 도 11은 총 58개 시료(21번 삼염색체를 갖는 태아를 갖는 여성으로부터 취한 3개의 시료 포함)에 대한 qPCR 실행시 각 시료에 대하여, 기준 염색체(5번 및 12번)의 양에 대한 21번 염색체의 양(21번 염색체:C21orf57에 위치하는 하나의 표적 DMR에 의해 결정됨)의 정규화된 비율[y축]과, 기준 염색체의 양에 대한 21번 염색체의 양(21번 염색체:C21orf57에 위치한 다른 표적 DMR에 의해 결정됨)의 정규화된 비율[x축]을 나타내는 산포도이다. 여기서 상기 양들은 실시예 4에 기재된 분석에 의해 기술되는 발명 방법에 의해 결정되는데, 단, 표 6에 기재된 것은 제외한다. 21번 삼염색체(T21)를 갖는 태아를 수태한 여성을 나타내는 포인트는 빈 사각형으로 표시되어 있으며, 이들은 검정 사각형으로 표시된 Non-T21 시료들과 구별되도록 무리지어 있다. 모든 거짓양성은 '+'로 표시하였고 거짓음성은 'X'로 표시하였다.
[30] 도 12는 실시예 10에서 설명된 분석법 V10.1에 의해 기술된, 총 56개 시료(21번 삼염색체를 갖는 태아를 갖는 여성으로부터 취한 4개의 시료 포함)에 대한 qPCR 실행시 각 시료에 대한 산포도이다. 포인트들은 도 11에서와 같다. 도 11에서와 같이, y축의 염색체 21 DMR은 C21orf57이고, x축의 염색체 21 DMR은 DSCAM이다.
[31] 도 13은 실시예 10에서 설명된 분석법 V10.2에 의해 기술된, 총 58개 시료(21번 삼염색체를 갖는 태아를 갖는 여성으로부터 취한 3개의 시료 포함)에 대한 qPCR 실행시 각 시료에 대한 산포도이다. 포인트들은 도 11에서와 같다. 도 11에서와 같이, y축의 염색체 21 DMR은 C21orf57이고, x축의 염색체 21 DMR은 DSCAM이다.
[32] 도 14는 실시예 10에서 설명된 분석법 V10.3에 의해 기술된, 총 58개 시료(21번 삼염색체를 갖는 태아를 갖는 여성으로부터 취한 2개의 시료 포함)에 대한 qPCR 실행시 각 시료에 대한 산포도이다. 포인트들은 도 11에서와 같다. 도 11에서와 같이, y축의 염색체 21 DMR은 C21orf57이고, x축의 염색체 21 DMR은 DSCAM이다.
[33] 도 15는 실시예 10에서 설명된 분석법 V10.4에 의해 기술된, 총 58개 시료(21번 삼염색체를 갖는 태아를 갖는 여성으로부터 취한 3개의 시료 포함)에 대한 qPCR 실행시 각 시료에 대한 산포도이다. 포인트들은 도 11에서와 같다. 도 11에서와 같이, y축의 염색체 21 DMR은 C21orf57이고, x축의 염색체 21 DMR은 DSCAM이다.
[34] 도 16은 실시예 10에서 설명된 분석법 V10.5에 의해 기술된, 총 58개 시료(21번 삼염색체를 갖는 태아를 갖는 여성으로부터 취한 2개의 시료 포함)에 대한 qPCR 실행시 각 시료에 대한 산포도이다. 포인트들은 도 11에서와 같다. 도 11에서와 같이, y축의 염색체 21 DMR은 C21orf29이고, x축의 염색체 21 DMR은 DSCAM이다.
[35] 도 17은 실시예 10에서 설명된 분석법 V10.6에 의해 기술된, 총 58개 시료(21번 삼염색체를 갖는 태아를 갖는 여성으로부터 취한 2개의 시료 포함)에 대한 qPCR 실행시 각 시료에 대한 산포도이다. 포인트들은 도 11에서와 같다. 도 11에서와 같이, y축의 염색체 21 DMR은 C21orf49이고, x축의 염색체 21 DMR은 DSCAM이다.
[36] 이하, 본 발명의 특정 비제한적 양태 및/또는 구현형태를 상세하게 설명한다.
[37] 제1 양태로서, 본 발명은 임신여성에 수태된 태아의 염색체 이수성(chromosomal aneuploidy)을 검출하는 방법에 관한 것이다. 이 방법은
(a) 모체에서 유래한 상이하게 메틸화된 DNA와 혼합된, 태아의 세포 및/또는 태아의 태반으로부터 유래된 DNA를 포함하는, 상기 임신여성으로부터 채취한 시료를 제공하는 단계;
(b) 메틸화 및 비메틸화된 DNA를 상이하게 변형(modify)시키는 시약으로 상기 시료에 존재하는 DNA를 처리하는 단계;
(c) 상기 시료에서 염색체 이수성과 관련된 염색체인 제1 표적 DNA 종(target species of DNA)의 양(amount)을 결정하되, 상기 염색체에 위치하는 둘 이상의 제1 표적의 상이한 메틸화 영역(제1 표적 DMR)에 메틸화가 존재하는지를 상기 시료에서 검출함으로써 결정하는 단계; 여기서, 상기 제1 표적 DMR은 태아의 세포 및/또는 태아의 태반에서 유래한 DNA와 모체 유래 DNA 간에 상이하게 메틸화된 영역이고, 제1 표적 DMR의 DNA의 상기 시약에 의한 변형은 DNA의 메틸화에 감응한다. 그리고 상기 제1 표적 DMR 중 하나 이상에서의 메틸화 DNA의 검출량은 상기 시료 내의 상기 제1 표적 DNA 종의 양을 나타낸다.
(d) 상기 시료에서 하나 이상의 기준 염색체인 기준 DNA 종의 양을 결정하되, 상기 기준 염색체(들)에 위치하는 둘 이상의 기준 DMR에 메틸화가 존재하는지를 상기 시료에서 검출함으로써 결정하는 단계; 여기서, 상기 기준 DMR은 태아의 세포 및/또는 태아의 태반에서 유래한 DNA와 모체 유래 DNA 간에 상이하게 메틸화된 영역이고 상기 기준 DMR의 DNA의 상기 시약에 의한 변형은 DNA의 메틸화에 감응한다. 그리고 상기 기준 DMR 중 하나 이상에서의 메틸화 DNA의 검출량은 상기 시료 내의 상기 기준 DNA 종의 양을 나타낸다.
(e) 단계 (c)에서 결정된 양과 단계 (d)에서 결정된 양의 상대적 양(들), 바람직하게는 비율(들)을 결정하는 단계; 여기서, 상기 하나 이상의 상대적 양(들)은 태아 내의 염색체 이수성의 존재 또는 부존재를 지시한다(indication).
상기 방법에서 바람직하게는, 단계 (c) 및 단계 (d)에서의 상기 검출은 상기 시료의 동일한 DNA 분취량(aliquot)을 사용하여, 그리고 동일 용기에서, 그리고 상기 제1 표적 DMR 및 상기 기준 DMR에 대해 유효하게 동시에 수행되며, 그리고 선택사항(옵션)으로서 (x) 상기 기준 DMR의 적어도 두 개에 대해 동일한 검출 표지(들)를 사용하여서 그리고/또는 (y) 상기 제1 표적 DMR의 적어도 두 개에 대해 상이한 검출 표지를 사용하여서 수행된다.
[38] 본 명세서에 사용된 용어들은 다른 명시가 없는 한 그들의 일반적인 의미로 이해되어야 한다. 여기서 사용된 용어 '포함하는'(comprising, comprising of)은 다른 구성요소들을 배제하지 않는다는 의미이다. 본 발명의 목적상, '구성되는'(consisting of)이라는 용어는 위 '포함하는'이라는 용어의 특정 구현형태로 간주한다. 이하에서 하나의 그룹이 특정 개수 이상의 구현형태를 포함하도록 정의된 경우에, 이는 또한 이들 구현형태 모두 그리고/또는 오직 이들 구현형태로만 구성되는 그룹을 개시한다는 것으로 이해해야 할 것이다. 본 명세서에서 사용된 '및/또는' 또는 '그리고/또는'은 어떠한 두 개의 특징 또는 구성요소의 어느 하나가 다른 하나와 함께 하거나 함께 하지 않는 것으로 취급되어야 한다. 예를 들어, 'A 및/또는(그리고/또는) B'는 (i) A, (ii) B, (iii) A 및 B와 같이 각각이 모두 개별적으로 개시된 것과 동일하게 취급된다. 본 발명의 맥락에서, '약(about)' 및 '대략(approximately)'은 당해 기술분야의 통상의 지식을 가진 자(당업자)가 해당 특징의 기술적 효과의 보장을 위해서 이해할 정도의 정확도 간극을 나타낸다. 이 용어는 일반적으로, 예를 들어 ±20%, ±15%, ±10%, ±5%와 같이 적시된 수치값의 편차를 나타낸다. 특정 기술 효과에 대한 이러한 수치값의 특정 편차는 해당 기술 효과의 속성에 의존할 것임을 당업자는 알 것이다. 예를 들어, 자연 또는 생물에서의 기술 효과는 일반적으로, 인공적인 또는 엔지니어링적인 기술 효과의 편차보다 더 큰 편차를 가질 수 있다. 단수 명사 언급시에 부정관사 또는 정관사, 예를 들어 'a', 'an', 'the'를 사용한 경우에, 여기에는 특별히 명기되지 않은 한 해당 명사의 복수형도 포함된다.
[39] 본 발명의 특정 구현형태에서, '임신여성(pregnant female)'은 인간이거나 비인간 동물이며, 이 비인간 동물은 특정 구현형태에서 말, 양, 소, 돼지, 닭, 마우스, 및 랫으로 구성된 그룹 중에서 선택할 수 있다. 보다 구체적인 구현형태에서, 임신여성은 의학적 증상(예를 들어, 본 명세서에 개시된 하나 이상의 의학적 증상)을 앓고 있는 위험 또는 그 발병의 위험이 증가하는 것으로 의심될 수 있다. 이러한 본 발명 방법은 인간 또는 동물의 신체에서 실시하는 것으로 의도된 것은 아니다. 예를 들어, 체외(in-vitro) 방식으로도 실시할 수 있도록 의도된 것이다.
[40] 본 발명의 특정 구현형태에서, 전술한 DNA 종(species of DNA) 및/또는 상기 상이하게 메틸화된 DNA는 무세포 DNA이고, 특히 이 구현형태에서는 순환 무세포 DNA(circulating cell-free DNA)이다. 한 특정 구현형태에서, 상기 DNA 종 및 이와 혼합된 상이한 메틸화 DNA는 순환 무세포 DNA이다. '무세포 DNA'(cfDNA) 란 용어는 기술계에서 인정되어 있으며 개체의 체액(예를 들어, 혈액 또는 혈액성분)과 같이, 세포 밖에서 발견되는 DNA라는 의미를 포함한다. '순환(circulating)'도 또한 기술적으로 인정되는 용어이며, 개체의 순환계(혈액 시스템 또는 림프 시스템)에 실체 또는 물질(예를 들어, cfDNA)이 존재하거나 검출 또는 확인되거나 이로부터 분리되어 있다는 의미를 포함한다. 특히, cfDNA가 '순환'하는 경우에는 cfDNA가 세포 내에 위치하지 않고, 따라서, 혈장이나 혈청에 존재하거나 림프액의 림프 내에 존재할 수 있다.
[41] 용어 '상이한 메틸화 영역' 또는 'DMR(differentially(또는 differently) methylated region)'을 당업자는 알고 있을 것이며, 또한, 이 용어는 시료 내에 혼합된 상기 (태아의) DNA 종과 그 외 (모체의) DNA 간에 상이하게 메틸화된(예를 들어, CpG 모티프에서) 염색체 DNA 내의 영역을 의미하는 것으로 의도된 것이다. 예를 들어, 본 발명에서 DMR은 태아 및 모체 DNA 간에 상이하게 메틸화되는데, 본 발명의 특정 구현형태에서 DMR은 태아 DNA에서 과다 메틸화되고(hypermethylated) 모체 DNA에서는 저도 메틸화된다(hypomethylated). 즉, 이러한 영역에서 상기 (태아의) DNA 종에서의 메틸화 정도가 다른 (모체) DNA와 비교하여 더 큰데(즉, 더 높은데), 예를 들어, 주어진 DMR에서, 다른 (모체) DNA 내의 메틸화 가능 부위에 비교하여 약 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 또는 100% 이상의 해당 부위가 상기 (태아의) DNA 종에서 메틸화된다. 특정 구현형태에서, 상기 영역은 모체 DNA에서는 약 10% 미만 메틸화되고, 태아 DNA에서는 약 30% 초과(예를 들어, 약 50% 초과) 메틸화된다.
[42] 당업자가 이해할 수 있는 바, 용어 '양(amount)'은 농도, 게놈 당량, 몰수, 질량 등의 변수, 그리고 이들 변수의 대체값을 나타낼 수 있다. 예를 들어, 아날로그 또는 디지털의 (계수) 정량화 기술로 생성된 것과 같은 (정량적인) 신호 또는 측정치도 또한 '양'으로 간주할 수 있다. 특히, 정량화 PCR(quantitative PCR)을 사용하는 본 발명 방법의 구현형태에서, '양'은 qPCR 장치에 의해 취합된 측정치, 예를 들어 Ct(Threshold cycle)로 나타낼 수 있다. 여기서 Ct는 qPCR로부터의 (형광) 신호가 문턱값을 넘어가는 싸이클(주기)의 수를 나타낸다. (Ct는 LightCycler에서 사용하는 용어로 Cp(크로스포인트 사이클(cross point cycle))라고도 부름) 당업자가 이해할 수 있는 바, 이 Ct(또는 Cp) 수는 정량화된 DNA 템플릿(예를 들어, 상이하게 메틸화된 DNA 종)의 초기 농도(양)와 역상관(inversely correlate)된다.
[43] 본 발명 방법의 단계 (e)에서, 단계 (c)에서 결정된 양과 단계 (d)에서 결정된 양의 상대적 양(relative amount)은 태아 내의 염색체 이수성(aneuploidy)의 존재 또는 부존재를 지시(indicate)한다. 예를 들어, 정배수체(euploid) 시료에서 예상되는 것에 비해 (염색체 이수성에 연관된 염색체인) (제1) 표적 DNA 종의 양이 과다하거나 또는 증가하였다는 것은(예를 들어 하나 이상의 기준 염색체인 기준 DNA 종과의 비교시) 이 표적 DNA 종의 양이 과다하게 존재한다는 것을 나타내고 이는 염색체 이수성에 연관된 염색체의 부분적인 또는 완전한 복사본(copy)이 태아에 있음을 나타낸다. 특히, 이러한 표적 DNA 종의 과다한 양은 인간의 21번 삼염색체(trisomy 21; T21)와 같은 부분적인 또는 완전한 삼염색체를 지시하는 것일 수 있다. 이에 대조적인 예로, 정배수체 시료에서 예상되는 것에 비해 (염색체 이수성에 연관된 염색체인) (제1) 표적 DNA 종의 양이 결핍되거나 또는 감소하였다는 것은(예를 들어 하나 이상의 기준 염색체인 기준 DNA 종의 양과 비교시) 이 표적 DNA 종의 양이 줄어들어 존재한다는 것을 보여주고 이는 염색체 이수성에 연관된 염색체의 적어도 하나의 복사본(copy)의 전부 또는 일부가 태아에 존재하지 않음을 나타낸다. 특히, 표적 DNA 종의 이러한 감소된 양은 터너증후군(45,X)과 같은 부분적 또는 완전한 염색체 손실(예를 들어, 단염색체(monosomy))을 나타낼 수 있다.
[44] 단계 (c)에서 결정된 양 및 단계 (d)에서 결정된 양은 이론적 측면에서 비교할 수 있다. 예를 들어, 인간 삼염색체(예를 들어, T21, T18, 및/또는 T13)의 경우 제1 표적 DNA 종(염색체 이수성과 관련된 염색체임)의 양은 이론적으로 기준 DNA 종(하나 이상의 기준 염색체)의 양에 대해 3:2의 비율을 갖는다. 그러나 표적 염색체 및/또는 기준 염색체의 상이한 영역(및/또는 DMR)에 대한 검출 감도 및 정량화의 차이로 인해, 이러한 이론적 비율은 실제로 일어나지 않을 수도 있다. 따라서, 단계 (c)에서 결정된 양이 단계 (d)에서 결정된 양과 동등(equvalent)하지 않은 경우에 태아에 염색체 이수성이 존재함이 지시될 수 있는데, 이 경우 양이 동등하다고 하여 동일한 값을 가짐을 의미하는 것은 아니다. 실제로, 태아 내의 염색체 이수성의 존재는, 정수배체 태아에 대해서 예상되는 양(가령, 단계 (d)에서 결정된 양)과 단계 (c)에서 결정된 양의 차이, 왜곡, 또는 그 밖의 편차에 의해서도 지시될 수 있는 것이다.
[45] 당업자가 알 수 있듯이, 태아에의 염색체 이수성의 존재(또는 부존재)를 모든 상황 또는 시료에서 명확하게 지시하는 것이 가능하지 않을 수도 있다. 따라서, 본 발명은 또한, 단계 (e)에서 태아 내의 염색체 이수성의 존재(또는 부존재)를 지시하는 것이 결정적인 것이 아닌, 있을 법한 또는 가능성 있는 존재(또는 부존재)를 지시하는 방법을 상정하고자 한다. 이렇게 상정되는 본 방법은, 더 확실하거나 신뢰성있거나 결정적인 진단 결과를 얻기 위해 추가 진단 검사를 수행하기 위한 신호전송 또는 플래그설정 단계를 추가로 포함하는 구현형태를 포함한다. 이러한 후속 검사는 태아의 이수성 검출을 위한 다른 NIPT(실시예 1에 기재된 바와 같은 NGS 기반의 NIPT)를 포함하거나 CVS 또는 양수천자를 포함할 수 있다.
[46] 본 발명 방법의 특정 구현형태에서, 단계 (c) 및 단계 (d)에서의 상기 검출은 (x) 적어도 두 개의 상기 기준 DMR에 대해 동일한 검출 표지(들)를 사용하여서 그리고 (y) 적어도 두 개의 상기 제1 표적 DMR에 대해 상이한 검출 표지를 사용하여서 수행된다. 특히 이 구현형태에서, 단계 (c) 및 단계 (d)에서의 상기 검출은 (x) 상기 적어도 두 개의 기준 DMR의 각각에 대해 동일한 검출 표지(들)를 사용하여서 그리고 (y) 상기 적어도 두 개의 제1 표적 DMR에 대해 상이한 검출 표지를 사용하여서 수행된다.
[47] 위와 같은 본 발명 방법의 대안적 구현형태로서, 단계 (c) 및 단계 (d)에서의 상기 검출은 (x) 적어도 두 개의 상기 제1 표적 DMR에 대해 동일한 검출 표지(들)를 사용하여서 그리고 (y) 적어도 두 개의 상기 기준 DMR에 대해 상이한 검출 표지를 사용하여서 수행된다. 특히 이 구현형태에서, 단계 (c) 및 단계 (d)에서의 상기 검출은 (x) 상기 적어도 두 개의 제1 표적 DMR의 각각에 대해 동일한 검출 표지(들)를 사용하여서 그리고 (y) 상기 적어도 두 개의 기준 DMR에 대해 상이한 검출 표지를 사용하여서 수행된다.
[48] 위와 같은 본 발명 방법의 다른 대안적 구현형태에서, 단계 (c) 및 단계 (d)에서의 상기 검출은 (x) 적어도 두 개의 상기 기준 DMR에 대해(바람직하게는 각각에 대해) 동일한 검출 표지(들)를 사용하여서 그리고 (y) 적어도 두 개의 상기 제1 표적 DMR에 대해(바람직하게는 각각에 대해) 동일한 검출 표지를 사용하여서 수행된다. 여기서 (x)에 사용된 검출 표지(들)는 (y)에 사용된 검출 표지(들)와 상이하다.
[49] 위와 같은 본 발명 방법의 또다른 대안적 구현형태에서, 단계 (c) 및 단계 (d)에서의 상기 검출은 (x) 적어도 두 개의 상기 제1 표적 DMR에 대해(바람직하게는 각각에 대해) 상이한 검출 표지(들)를 사용하여서 그리고/또는 (y) 적어도 두 개의 상기 기준 DMR에 대해(바람직하게는 각각에 대해) 상이한 검출 표지를 사용하여서 수행된다.
[50] 특정 구현형태에서, 상이한 검출 표지(들)는, 기준 DMR에 대해 사용되는 것처럼 ― 만일 본 방법에 OR(들)이 이용되는 경우에는, 이 OR(들)에 대해 사용되는 것처럼 ― 상기 제1 표적 DMR에 대해 사용된다.
[51] 본 발명의 특정 구현형태에서, 단계 (c)에서는 2개보다 많은 제1 표적 DMR이 이용될 수 있다. 예를 들어, 3개, 4개, 5개, 6개, 7개, 8개, 9개, 또는 9개보다 많은 제1 표적 DMR을 이용할 수 있다(예를 들어, 약 10개, 15개, 20개, 30개, 50개, 또는 50개보다 많은 제1 표적 DMR). 적어도 2개의 상기 제1 표적 DMR에 대해 상이한 검출 표지(들)가 사용되는 발명의 구현형태들에서는, 하나 이상의(바람직하게는 2개, 3개, 4개, 5개, 또는 5개 초과의) 다른 제1 표적 DMR을 다른 검출 표지(들)를 사용하여 검출할 수 있다. 이와 다른 대안적 구현형태에서는, 적어도 2개의 상기 제1 표적 DMR에 대해서는 상이한 검출 표지(들)를 사용하고, 하나 이상의(바람직하게는 2개, 3개, 4개, 5개, 6개, 7개, 8개의, 또는 8개 초과의) 다른 제1 표적 DMR에 대해서는 상기 두 개의 제1 표적 DMR 중 하나에 대해 동일한 검출 표지(들)를 사용할 수 있다. 예를 들어, 2개의 제1 표적 DMR에는 동일한 검출 표지(들)를 사용할 수 있고, 2개의 다른 제1 표적 DMR에는 상이한 검출 표지(들)를 사용할 수 있다. 이러한 구현형태는 검출 표지(들)를 추가하지 않고도 특정도와 감도를 더 증가시킬 수 있으며, 표지 개수를 다중 채널 검출 장비의 주어진 비용 및 기술적 요구 그리고 예를 들어 형광 표지의 경우의 검출 스펙트럼 및 탈색의 중첩을 실제적으로 제한할 수 있어서, 본 발명에 추가적인 이점을 제공할 수 있다.
[52] 본 발명에서는, 메틸화되지 않은 DNA에 비해 메틸화된 DNA를 상이하게(예를 들어, 선택적으로) 변형(modify)시키는 시약이 사용된다. 예를 들어, 바이설파이트(bisulphite 또는 bisulfite)가 포함된 시약으로 DNA를 처리하여 시토신 잔기(cytosine residues)를 우라실로 전환시키되, 5-메틸시토신 잔기에는 영향을 주지 않도록 한다. 따라서, 바이설파이트 처리는 개별적인 시토신 잔기의 메틸화 상태에 의존하는 DNA 서열에서의 특이적인 변화를 유도하고, 이로써 DNA 세그먼트의 메틸화 상태에 관한 단일 뉴클레오티드 해상도 정보를 낳게 한다. 이 정보를 검색하기 위해 변경된 서열에 대한 다양한 분석(상기 단일 뉴클레오티드의 변화를 구별할 수 있는 PCR 프라이머 및/또는 프로브의 사용이 포함됨)을 수행할 수 있다.
[53] 이러한 시약은 대안적으로(또는 부가적으로) DNA 메틸화의 상태에 감응성있는 제한효소를 포함할 수 있다. 이러한 제한효소의 인식 서열(recognition sequence)의 분할(cleavage)은 효소의 인식 부위의 특정 염기가 변형될 때(예를 들어, 메틸화) 차단(block)되거나 손상(impair)될 수 있다. 본 발명의 모든 양태의 특정 구현형태에서, 시약은 본 명세서에 개시된 메틸화에 감응하는(methylation-sensitive) 제한효소와 같은 메틸화 감응성 제한효소를 포함한다. 본 발명에는 이러한 메틸화 감응성 제한효소를 2개, 3개, 4개, 5개 또는 그 이상 포함하는 구현형태가 포함된다.
[54] 단계 (b) 이전에, 시료 내 존재하는 DNA를 분리, 농축, 및/또는 정제하기 위해 시료 가공이 이루어질 수 있다. 예를 들어, 혈장 시료를 cfDNA 분리 공정 또는 키트를 사용해 처리하여서 전술한 DNA 종과 태아 및/또는 태아의 태반에서 온 것이 아닌 (예를 들어, 모체 유래의) 상이한 메틸화 DNA의 혼합물을 포함하는 (비자연적인) 후속 용액을 만들 수 있다. (b)의 처리 단계는 상기 시약(예를 들어, 메틸화 감응성 제한효소)을 포함하는 별도의 용액을, 시료의 혼합된 DNA(예를 들어, 상기 혼합된 DNA를 포함하는 비자연적 용액)에 첨가하는 단계를 포함할 수 있으며, 그리고/또는 특정 상태를 유지(또는 특정 상태로 변경)하는 것을 포함할 수 있다. 특히, 상기 시약이 하나 이상의 메틸화 감응성 제한효소를 포함하는 경우, (b)에서의 처리 단계는 DNA 및 효소를 함께 약 37℃에서 약 5분 내지 300분 동안, 가령, 약 30분 내지 90분(또는 60분) 동안 인큐베이팅하는 것을 포함할 수 있다. 그리고, 선택적 임의사항으로서, 효소(들)를 비활성화시키기 위해 더 고온(예를 들어, 약 50℃ 내지 90℃, 예컨대 약 80℃)에서 상기 혼합물을 인큐베이팅하는 것을 포함한다. 특정 구현형태에서, (b)의 처리 단계에서 형성된 조성물은 비자연적으로 형성될 수 있다. 예를 들어, 용액(또는 완충액)의 성분 중의 특정 염 및/또는 하나 이상의 세균 유래 제한효소(또는 그의 비자연적 돌연변이체)와 cfDNA(예를 들어 인간의)의 혼합물은 비자연적 조성물 또는 혼합물일 수 있다. 또한, 본 발명 방법들 중 어느 하나는 체외에서 생성된 핵산 분자, 예를 들어 PCR 반응의 DNA 산물(예를 들어, 'PCR 산물')을 생산할 수 있다(따라서 본 발명의 조성물은 상기 체외에서 생성된 핵산 분자를 포함할 수 있다). 상기 체외에서 생성된 핵산 분자 중 하나 이상은, 적어도 하나의 검출 표지를 포함하는 뉴클레오티드 프라이머 및/또는 프로브를 포함하기 때문에 비자연적일 수 있는데, 여기서, 상기 핵산 분자는 상기 표지처리된 프라이머 및/또는 프로브의 폴리머라제 확장(또는 부분적 핵산 분해(partial nuclease digestion))에 의해 생성된 것으로, 검출 표지를 포함하는 상기 핵산 분자의 적어도 일부분을 제공한다. 이로써 핵산 분자의 핵산 서열이 자연적으로 발생된 서열(또는 그 단편)일지라도, 상기 체외 생성 핵산 분자는 여기에 포함된 (적어도) 비자연적인 검출 표지로 인해서 비자연적이다. 특정 구현형태에서, 단계 (b) 전에, 상기 임신여성으로부터 채취한 시료를 처리하여 상기 시료에 존재하는 DNA를 추출할 수 있다. 예를 들어, 이 처리 단계에서는 상기 시료로부터 전체 무세포 DNA를 추출할 수 있거나, 또는 상기 처리 단계는 태아 무세포 DNA를 추출 및/또는 농축할 수 있다.
[55] 본 발명 방법의 특정 구현형태들에서, 단계 (e)에서 결정된 상대적 양(들) 또는 비율(들)은 임계값(들) 및/또는 기준 분포(들)와 비교되는데, 여기서 상기 임계값 및/또는 기준 분포(들)보다 높거나 낮은 하나 이상의(바람직하게는 둘 이상의) 상기 상대적 양(들) 또는 비율(들)은 태아 내의 염색체 이수성의 존재를 지시한다. 상기 임계값(들) 및/또는 기준 분포(들)는 대조 시료 연구 등 선행 연구로부터 얻거나, 본 발명 방법에 의해 분석된 다수의 시료로부터 생성가능하다. 예를 들어, 다수의 다른 시료들(가령, 약 10, 20, 30, 40, 50, 60, 80, 90, 100, 120, 150, 175, 200, 250, 500개, 또는 500개 초과의 시료, 특히 약 60개의 시료, 더 특별히는 500개 이상의 시료)을 분석하여 하나 또는 다른 개별 시료가 단계 (c)로부터 결정된 양 또는 (e)로부터 결정된 상대적 양이 다른 대부분의 시료들로부터의 유사한 양의 모집단에 대하여 이탈값(outlier)을 보이면, 이는 각 시료가 채취된 임신여성이 수태한 태아가 염색체 이수성을 가지고 있음을 나타내는 것이다. 전술한 바와 같이, 단계 (e)에서 결정된 상대적 양(들) 또는 비율(들)을 임계값(들) 및/또는 기준 분포(들)와 비교하더라도, 태아 내의 염색체 이수성의 존재(또는 부존재)가 모든 상황이나 모든 시료에서 명확하게 지시될 수 있는 것은 아니다. 따라서, 본 발명의 상기 구현형태들에서는 또한, 염색체 이수성의 존재(또는 부존재)를 명확하게 지시하기 보다는 있을 법한 또는 가능성 있는 존재(또는 부존재)를 지시하는 구현형태가 포함된다. 여기에는 더 확실하거나 명확한 진단 결과를 내기 위해 추가적인 진단 검사를 수행하는 신호전송(signalling) 또는 플래그설정(flagging) 단계를 추가로 포함하는 구현형태가 포함된다. 이러한 추가적 진단 검사는 실시예 1에 기재된 바와 같은 NGS 기반의 NIPT와 같이 본 명세서의 다른 곳에서 설명하고 있다.
[56] 이에 대신하여 또는 부가적으로, 염색체 이수성이 태아에 존재함의 지시(indication)는 (i) 기준 DNA 종의 양(예를 들어, 기준 DMR에서 결정된 양)을 나타내는 척도 또는 신호와 관련하여 예상되는 양 대비, 제1 표적 DNA 종의 양(예를 들어, 하나의 제1 표적 DMR 또는 다른 제1 표적 DMR로부터 결정된 양)을 나타내는 척도 또는 신호의 증가(또는 감소)를 고려하여서, 그리고/또는 (ⅱ) 시료에서 결정된 제1 표적 DNA 종의 양(예를 들어, 예를 들어, 기준 분포를 고려하여서 하나의 제1 표적 DMR 또는 다른 제1 표적 DMR로부터 결정된 양)이 감소하였는지를 판단해서 평가할 수 있다.
[57] 특정 구현형태에서, 임계값(들)은 표준 대조군을 이용해 설정할 수 있다. 예를 들어, 기지의 알고 있는 시료(또는 다수의 기지의 시료들)로부터 한 번의(또는 개별적인) 실험을 통해 설정할 수 있으며, 그리고/또는 임계값(들)은 피검 시료(또는 피검 시료들)와 대략 동일한 시간에, (예컨대, 하나의 시료 또는 다수의 기지의 시료들로부터) 설정할 수 있다. 예를 들어, 이러한 임계값(들)의 설정은 동일한 실행(run)에서 가능한데, 구체적으로, 마이크로타이터 플레이트(microtiter plate)의 웰에 시료를 담을 때 하나 이상의 기지의 시료는 하나 이상의(별개의) 웰(well)에 담고 하나 이상의 피검 시료는 다른 웰에 담아서 본 발명 방법을 실시함으로써 가능하다. 본 발명의 다른 구현형태에서, 임계값의 양 및/또는 기준 분포 양과의 비교는 기준 DNA 종(즉, 기준 염색체)의 양에 대한 제1 표적 (또는 제2 표적) DNA 종(즉, 염색체 이수성에 관련된 염색체)의 상대적 양(가령, 비율)으로 얻어진다. 예를 들어, 이론적인 관점에서 볼 때 인간 염색체 21번의 정상적인 이배체(diploid) 군에서 유래한 제1 표적 DNA 종의 양은, 예를 들어 염색체 2번의 기준(이배체) 군에서 유래한 기준 DNA 종의 양에 대해 약 2:2(즉, 1:1)의 비율을 나타낼 것으로 예상된다. 그러나 21번 삼염색체의 경우에 상기 비율은 약 3:2일 것으로 예상된다. 당업자라면 이제 이해할 수 있는 바, 다른 염색체(또는 부분 염색체) 이수성은, 완전한 염색체 손실의 경우에는, 또는 제2 DNA 종의 위치를 포함하는 기준 염색체에 비해 제1 DNA 종의 위치가 부분적으로 삭제되는 부분 손실의 경우에는, 다른 이론비, 가령 1:2를 보일 것으로 예상된다. 특정 구현형태에서, 예를 들어 메틸화의 차이로 인해 상이하게 되지 않는 한, 이수성의 태아 cfDNA와 혼합된 정배수성의 모체 cfDNA와 같은 다른 DNA의 존재(즉, 다른 DNA와의 혼합물에서의 존재)는, (정배수성의) 모체 cfDNA와 (이수성의) 태아 cfDNA의 상대적 양에 따라 상기 비율을 변형시키는 결과를 낳을 수 있다. 당업자가 또한 이해할 수 있는 바, 상기 비율 변형은 각 앰플리콘(amplicon)의 상대적 반응(예를 들어, PCR 반응) 효율과 같은 다른 요인으로부터 일어날 수도 있다. 따라서, 상기 특정 구현형태에서, 임계값은 약 3:2(150%), 약 2:3(66%), 약 1:2(50%), 또는 약 2:1(200%) 등과 같이 (검출가능하게 그리고/또는 중요하게) 2:2(100%)보다 크거나 작은 비율이며, 또한, 이 구현형태에는, 약 200% 초과의, 약 50% 미만의, 또는 약 190%, 180%, 170%, 160%, 150%, 140%, 130%, 120%, 110%, 105%, 95%, 90%, 85%, 80%, 75%, 70%, 65%, 60%, 및 55% 중에서 선택된 하나의 임계값 및/또는 비율이 포함된다. 대안적으로, 특정 구현형태에서, 임계값은 터너증후군(완전 정배수성 '46,XX' 핵형보다는 '45,X' 핵형을 갖는 인간 여성)에서와 같이 오직 제1 표적(또는 제2 표적) DNA 종의 검출 가능한 양이 존재하지 않는 것으로써만 결정할 수도 있다. 그러나, 전술한 바와 같이, 표적 염색체 및/또는 기준 염색체(및/또는 DMR)의 상이한 영역에 대한 검출 감도 및 정량화의 차이인 상기 이론적 비율은 실제로는 일어날 수 없다. 따라서, 태아에서의 염색체 이수성의 존재는, 단계 (c)에서 결정된 양이 단계 (d)에서 결정된 양과 동등하지 않은 경우에 지시될 수 있다. 여기서, 상기 양의 동등성은 동일한 값을 갖는다는 것을 의미하는 것이 아니다. 실제로, 태아에서의 염색체 이수성의 존재는, 이수성 태아에게서 예상되는 양(가령, 단계 (d)에서 결정된 양으로부터 예상되는 양)과 비교하여 단계 (c)에서 결정된 양의 차이, 왜곡, 또는 다른 편차에 의해 지시될 수 있다.
[58] 특정 구현형태에서는, 평균, 중앙값, 표준 편차, 중앙 절대 편차, 또는 z-스코어 등의 파라미터가 각 실행, 플레이트, 또는 검출/분석 데이터 세트 내에서 일군의 시료에 대해서 계산된다. 이러한 특정 구현형태에서, 이와 같이 계산된 파라미터는 상기 실행, 플레이트, 또는 데이터 세트에서 검출/분석(예를 들어, '실행 특화(run-specific)' 분석)된 해당 피검 시료로부터 이탈값(outlier)(예를 들어, 삼염색체 시료)를 식별하는 데 사용된다. 특정 구현형태에서, 이러한 파라미터는 임의의 이탈값의 식별에 관한 지식없이 모든 피검 시료로부터 계산된다(예를 들어, '마스크(masked)' 분석). 다른 특정 구현형태에서, 이러한 파라미터는 (이탈값이 없는) 표준으로 알고 있는 기준 시료(예를 들어, 이수성 태아로부터의 cfDNA를 함유하는 것으로 알고 있는 시료) 또한 이러한 표준으로 추측되는(또는 아닐 수도 있는) 피검 시료들의 세트로부터 계산된다.
[59] 시료 분포와 기준 분포 간의 차이, 또는 기준 분포로부터의 이탈값(outlier)을 비교 및 검출하는 것은 당업자에게 알려져 있을 것이고, (one-tailed 또는 two-tailed의) t-테스트, Mann-Whitney Rank Sum 테스트, 및 기타 테스트(중앙 절대 편차 기반 z스코어(가령, Stumm 외 2014, Prenat Diagn 34:185에서 사용한 것)와 같은 z스코어의 사용이 포함됨). 본 발명의 특정 구현형태에서, 분포를 기준 분포와 비교(또는 기준분포로부터의 이탈값과 비교) 할 때에, 평균, 중앙값, 또는 개별 시료의 분리(separatiopn)가 기준 분포의 표준 분포(SD: standard distribution)보다 약 1.5, 1.6, 1.7, 1.8, 1.9, 1.95, 1.97, 2.0보다 크거나 2.0을 초과하는 경우에, 그리고/또는 개별 시료가 기준 분포로부터 약 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.5, 2.7, 2.8, 2.9, 3.0, 3.1, 3.2, 3.3, 3.5, 3.75, 4.0, 4.5, 5.0보다 크거나 약 5.0을 초과하는 z스코어로 분리되는 경우에 이 비교결과가 판정된다(그리고/또는 현저하게 다르다고 확인된다).
[60] 특정 구현형태에서, 데이터 세트의 맥락에서 z스코어(또는 파라미터 반복의 분포패턴에 기초한 동등한 통계치)는 이탈값 데이터의 포인트(들)(예를 들어, 자간전증(preeclampsia)을 앓고 있는 또는 발병할 위험이 증가할 것으로 예상되는 임신여성을 식별하기 위한 검사의 경우에서와 같이 DNA 종의 양이 과다한 것을 나타내거나, 염색체 이수성을 갖는 태아를 식별하기 위한 검사의 경우에서와 같이 기준 염색체를 넘는 과다한 양의 염색체를 나타내는 데이터)를 확인하기 위해 계산될 수 있다. 데이터 세트로부터 상기 데이터 포인트(표시점)를 제외시키고 나서 이 데이터 세트에 대해서 후속적으로 z스코어 분석을 행하여 추가 이탈값을 찾는다. 이러한 반복적인 z스코어 분석은, 때로는 한 번의 실행에서 2개 이상의 이수성 시료를 취급시에 단일의 z스코어 분석 결과를 왜곡할 수 있고/또는 거짓양성(false positive)을 확인하기 위해 추적 검사가 가능하며 따라서 거짓음성을 회피하는 것이 (초기의) 거짓양성을 식별하는 것보다 잠재적으로 더 중요한 본 발명 방법을 이용하여 태아 염색체 이수성을 검출하는 데 특히 유용할 수 있다.
[61] 본 발명 방법의 실시는 제1 (또는 제2) 표적 DNA 종(예를 들어, 인간의 21번 염색체와 같이 염색체 이수성과 관련된 염색체 또는 그의 일부로부터의)과 기준 DNA 종(예를 들어, 12번, 5번, 또는 2번 염색체와 같은 기준 염색체 또는 그 일부로부터의)의 상대적 검출(또는 양 측정)을 가능하게 하며, 따라서, 태아의 염색체 이수성의 신속하고 간단하며 비용효율적인 검출, 식별, 또는 진단을 돕는다. 이 접근법은, 예를 들어 비교적 간단하고 신뢰성 있고 비용효율적인 qPCR 장비를 필요로 하며 비싸고 전문적인 고처리량의 차세대 시퀀싱 머신을 필요로 하지 않는 많은 실험실에서 더 용이하게 구축하고 실시할 수 있다. 실제로, 본 발명의 이러한 특정 구현형태에서, 상기 제1 표적 DMR의 단계 (c)에서의 검출 및 전술한 기준 DMR의 단계 (d)에서의 검출은, 상기 시료의 동일한 분취량의 DNA를 사용하여 그리고 동일한 반응/검출 용기에서, 그리고 상기 DMR에 대하여 유효하게 동시에 이루어지며, (x) 상기 기준 DMR 2개 이상에 대해 (바람직하게는 각각에 대해) 동일한 검출 표지(들)를 사용하고, (y) 상기 제1 표적 DMR 2개 이상에 대해 (바람직하게는 각각에 대해) 상이한 검출 표지(들)를 사용하여 이루어진다. 이들 구현형태에서 (표적 DMR 및 기준 DMR을 통하여) 제1 (또는 제2) 표적 DNA 종 및 기준 DNA 종을 상대적 검출, 식별, 또는 정량화는 것은, 동일한 반응/검출 용기에서 유효하게 동시에 실시되며, 유리하게는, 기준 DMR로부터 적어도 두 개의 제1 (또는 제2) 표적 DMR을 구별할 수 있는 검출 표지(들)를 사용하여 실시되고, 만일 옵션 단계 (f)가 적용된다면 이 단계에서 검출된 상응하는 OR들을 이용하여 실시된다. 상기 구현형태의 또다른 구현형태에서, 검출 단계 (c) 및 (d)는 동일한 반응/검출 용기에서 효율적으로 동시에 수행되며, 단계 (c)에서의 상기 검출 및 단계 (d)에서의 상기 검출은 다중형(멀티플렉스)의 실시간 정량적 프로브 기반 PCR을 써서 상기 DMR들 각각에 대해 특화된 적어도 하나의 표지처리된 프로브(및 OR 이용시에는 각 OR)를 사용하여 이루어진다.
[62] 본 발명의 모든 양태에는, 염색체 이수성의 존재가 태아 이상 및/또는 선천적 장애와 관련된 염색체 이상에 대한 이수성의 전부 또는 일부인 경우의 구현형태들이 포함된다. 예를 들어, 이러한 염색체 이상은 삼염색체(trisomy 21, trisomy 18, 또는 trisomy 13 등), 성염색체 이상(터너증후군, 클라인펠터 증후군, 누난 증후군, 트리플 X 증후군, XXY 증후군, 또는 취약한 X 증후군 또는 XYY 증후군 또는 XXYY 증후군 등), 염색체 결실(Prader-Willi 증후군, Cris-du-Chat 증후군, Wolf-Hirschhorn 증후군, 또는 22qll 결실 증후군, Duchene 근이영양증 등), Beckwith-Wiedemann 증후군, Canvan 증후군, 및 신경 섬유종증 중에서 선택된 하나일 수 있다. 이러한 이상의 확산 및 그에 따른 의학적, 사회적 중요성 측면에서 염색체 이상은, trisomy 21, trisomy 18, 또는 trisomy 13과 같은 삼염색체이다.
[63] 본 발명의 임신여성이 인간인 구현형태에서, 염색체 이수성과 관련된 염색체는 21번 염색체, 18번 염색체, 13번 염색체, X 염색체, 및 Y 염색체로 구성된 목록, 바람직하게는 21번 염색체, 18번 염색체, 13번 염색체로 구성된 목록에서 선택된 인간 염색체일 수 있다. 특히, 이들 구현형태에서 염색체 이수성과 관련된 염색체는 인간의 21번 염색체이다. 이러한 구현형태 중 특정의 것에서, 상기 염색체 이수성은 상기 염색체의 이(배)수체일 수 있다. 본 발명의 모든 양태에서, 염색체 이수성은 상기 염색체의 단염색체(monosomy) 또는 삼염색체(trisomy)인데, 이는, 당업자에게 공지되어 있겠지만, 상기 염색체의 부분적인 또는 완전한 단염색체 또는 삼염색체 같은 부분 이수성 또는 완전 이수성일 수 있다. 여기서 '부분' 이수성은 염색체의 일부분의 손실 또는 증가로 인한 유전 물질의 불균형이라는 의미를 포함한다. 예를 들어, 부분 이수성은 개체가 두 개의 다른 염색체의 파손과 융합을 통해 형성된 파생 염색체를 가지고 있는 불균형 전위(unbalanced translocation) 상황을 포함할 수 있다. 이 예에서 개체는 한 염색체의 일부의 복사본 3개(2본의 정상 복사본, 1본의 파생 염색체에 존재하는 부분)와, 파생 염색체에 포함된 다른 염색체의 부분에 대한 복사본 1개만 가질 수 있다.
[64] 이에 따라, 임신여성이 인간인 구현형태에서, 하나 이상의 기준 염색체(들)는 인간 염색체 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12번, 인간 염색체 14, 15, 16, 17번, 인간 염색체 19번, 인간 염색체 20번, 인간 염색체 22번, 및 인간 염색체 23번으로 구성된 목록에서 선택된 하나일 수 있다. 이 구현형태에서는 특히, 기준 염색체는 인간 염색체 5번 또는 인간 염색체 12번이다.
[65] 본 발명의 특정 구현형태에서, 상기 2개 이상의 기준 DMR은 상이한 기준 염색체에 위치한다. 예를 들어, 특정 구현형태에서, 상기 기준 DMR 중 하나는 인간 염색체 5번에 위치하고, 상기 기준 DMR의 다른 하나는 인간 염색체 12번에 위치한다.
[66] 그러나, 기준 염색체로서 사용되는 염색체 중 하나(또는 그 이상)의 염색체가 염색체 이수성과 관련될 수 있는 염색체이지만 염색체 이수성과 관련된 염색체와는 상이한 염색체인 구현형태도 본 검출 방법이 적용되는 경우에 본 발명의 범위 내에 포함된다. 예를 들어, 임신한 인간 여성에 의해 임신된 태아에서 21번 삼염색체를 검출하기 위해 본 발명 방법을 실시한다면, 예를 들어 인간 18번 염색체 또는 인간 13번 염색체, 특히 13번 염색체를 '기준' 염색체로 사용할 수 있다. 이러한 예에서, 태아가 21번 삼염색체와 13번 삼염색체 모두를 가지고 있을 가능성을 무시할 만하다면, 염색체 13번에 비해 염색체 21번이 과다하다는 것은 21번 염색체의 삼염색체를 나타내는 것일 것이다. 마찬가지로, 동일한 검사법을 사용하지만 대신에 13번 염색체가 본 검출 방법이 적용되는 염색체 이수성에 관련된 염색체인 것이라고 하면, 염색체 21번에 비해 13번 염색체가 과다하면(이는 염색체 13에 비하여 21번 염색체가 감소된 것과 동등함) 13번 염색체의 삼염색체를 나타내는 것이 될 것이다. 이러한 '기준' 염색체의 선택 및 본 발명 방법의 실행/고려는, 단일 분석에서의 염색체 이수성에 관련된 2 이상의 염색체에서 이수성이 존재(또는 부존재)하는지를 검출할 수 있는 가능성을 제공하는 특별한 이점을 갖게 될 것이다. 이러한 분석은 시간과 비용을 절약할 뿐만 아니라 하나의 시료에서 2 이상의 염색체 이수성의 존재를 검출할 수 있도록 할 것이다. 이에, 모체 시료에 일반적으로 존재하는 비교적 낮은 수준의 태아 유래 DNA가 주어지면, 임신여성에게서 시료를 채취하는 횟수를 줄이거나 더 적은 시료를 필요로 할 수 있게 될 것이다.
[67] 특정 구현형태에서, 본 발명 방법은 다음의 단계를 더 포함한다.
(f) 태아의 세포 및/또는 태아의 태반으로부터 온(유래된) DNA와 모체 유래의 DNA 간에 상이하게 메틸화되지 않은 적어도 하나의 타영역(OR: other region)을 검출함으로써 상기 시료에서 전체 DNA의 양을 결정하는 단계 ― 여기서 상기 시약에 의한 OR(들)의 변형은 DNA의 메틸화에 감응성이 없음.
여기서 바람직하게는 단계 (c) 및 단계 (d) 및 단계 (f)에서의 상기 검출은 상기 시료의 동일한 분취량의 DNA를 사용하여 그리고 동일한 용기에서, 그리고 상기 기준 DMR 및 상기 타영역에 대하여 유효하게 동시에 실시되며, 한 구현형태에서는, (x) 상기 기준 DMR 2개 이상에 대해 (바람직하게는 각각에 대해) 동일한 검출 표지(들)를 사용하고, 그리고/또는 (y) 상기 제1 표적 DMR 2개 이상에 대해 (바람직하게는 각각에 대해) 그리고 상기 OR(들) 하나 이상에 대해 (바람직하게는 각각에 대해) 상이한 검출 표지(들)를 사용하여 실시된다. 다른 대안적 실시예에서, 단계 (c) 및 단계 (d) 및 단계 (f)에서의 검출은 상기 기준 DMR의 2개 이상에 대해 (바람직하게는 각각에 대해), 상기 제1 표적 DMR의 2개 이상에 대해 (바람직하게는 각각에 대해), 그리고 상기 OR(들) 하나 이상에 대해 (바람직하게는 각각에 대해) 상이한 검출 표지(들)를 사용하여 실시될 수 있다.
[68] 본 발명에서 OR이 이용되는 경우에는, DMR과 다르게 '타영역' OR은 태아의 세포 및/또는 태아의 태반으로부터 유래된 DNA 종과 시료 속에서 이와 혼합되어 있는 모체 유래 DNA 간에 (상당량으로) 상이하게 메틸화되지 않는다. 예를 들어, 사용되는 시약의 조건 및 성질에 따라 다르지만, 상기 (태아) DNA 종의 타영역과 이에 혼합된 (모체) DNA의 타영역 간의 시약에 의한 변형에 거의 차이가 없다. 이러한 차이 없음은, 타영역이 메틸화 부위를 포함하지 않는 경우에, 또는 메틸화 부위가 존재한다면 메틸화의 정도에 차이가 없는 경우에, 또는 타영역에 존재하는 메틸화 부위를 인식하지 못하는 시약을 사용함으로써, 달성될 수 있다. 따라서, 본 발명의 대안적인 구현형태에서, 선택적(옵션) 단계 (f)에서 이용되는 적어도 하나의 타영역 OR은 상기 (태아) DNA 종과 다른 (모체) DNA 종 간의 메틸화에 (큰) 차이가 없는 것을, 상기 시약으로써 인식하거나 검출하지 못하는(또는 인식 또는 검출할 수 없는) 영역인 것이다.
[69] 본 발명 방법의 특정 구현형태에서, 상기 OR(들)은 하나 이상의 기준 염색체(들)에 위치한다. 임신여성이 인간인 경우에 상기 하나 이상의 기준 염색체(들)는 인간 염색체 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12번, 인간 염색체 14, 15, 16, 17번, 인간 염색체 19번, 인간 염색체 20번, 인간 염색체 22번, 및 인간 염색체 23번으로 구성된 목록에서 선택된 하나일 수 있다. 이 구현형태에서 특히, 기준 염색체는 인간 염색체 5번 또는 인간 염색체 12번이다. 본 발명의 특정 구현형태에서, 상기 2개 이상의 OR은 상기 2개 이상의 DMR처럼 동일한 기준 염색체(들)에 위치한다. 예를 들어, 상기 기준 DMR 중 하나와 상기 OR 중 하나는 모두 인간 염색체 5번 또는 인간 염색체 12번에 위치할 수 있다. 다른 구현형태에서, 상기 OR(들)은 염색체 이수성과 관련된 염색체(들)에 위치한다.
[70] OR(들)(즉, 상이하게 메틸화되지 않은 영역)은, 만일 이들이 본 발명에서 이용되는 경우, 본 발명에 이용되는 하나 이상의 DMR(예를 들어, 기준 DMR)과 중첩되지 않을 수 있다. 예를 들어, OR은 DMR(예를 들어, 기준 DMR) 중 하나(또는 전부)로부터 약 10bp, 20bp, 50bp, 또는 100bp, 500bp, 1kb, 또는 10kb보다 멀리 떨어져 위치할 수 있다(상기 DMR과 동일한 유전자 내에 위치하는 구현형태를 포함함). 예를 들어, 상기 DMR(예를 들어, 기준 DMR)의 상류(upstream) 또는 하류로(downstream) 약 20bp 내지 20kb 사이에 위치할 수 있다. 특히, 본 발명에서 OR이 이용되는 경우 OR의 게놈 위치는 일반적으로 게놈의 동일한 부분에 위치할 수 있다(상기 DMR과 동일한 유전자 내에 위치하는 구현형태를 포함함). 예를 들어 여기에 이용된 적어도 하나의 DMR(예를 들어, 기준 DMR)의 게놈 위치의 상류 또는 하류로 약 20bp 내지 약 20kb 사이에 위치할 수 있다. 특히 cfDNA의 태아분(foetal fraction)의 맥락에서, 이러한 DNA 종의 검출(및 특히 정량화)은 OR이 기준 DMR 중 하나와 동일한 게놈의 부분에 위치하는 경우에 향상된다(예를 들어, 감도, 정확도, 및/또는 정밀도의 향상). 이론을 따지지 않더라도, 이와 같은 유사하게 위치하는 DMR 및 OR이 특히 상기 상황에서 이용될 때에는, 게놈을 통과하는 크로마틴/뉴클레오좀 묶음의 변화의 효과 ― 따라서 게놈 DNA의 상이한 영역의 안정성/열화 ― 가 완화된다. 이로써, OR(전체 DNA를 검출함)에 비해 DMR(예를 들어 기준 DMR)(예를 들어, 태아 DNA의 기준 염색체 종을 검출함)의 안전성/열화의 차이가 적고, 따라서 상기 DMR과 OR 사이의 게놈을 통과하는 (크게) 상이한 크로마틴/뉴클레오좀 묶음에 의해 야기되는 정량적 차이에 의해 (크게) 어려움 없이 상대적(그리고 절대적) 정량화를 할 수 있게 된다.
[71] 본 발명에는 혼합체 중의 총 DNA 양의 검출을 위한 선택적 임의 단계 (f)에서 하나의 OR을 선택적으로 이용하는 것이 포함되지만, 또한, 하나보다 많은 OR을 이용하는 구현형태도 포함된다. 예를 들어, 본 발명에는 단계 (f)에서의 상기 검출시에 적어도 2개(가령, 2개, 3개, 또는 4개)의 상기 OR을 이용하는 구현형태가 포함된다. 본 발명의 모든 양태의 특정 구현형태에서, 선택적 임의 단계 (f)에서 이용되는 상기 OR의 수는 단계 (d)에서 이용되는 기준 DMR의 수와 동일하다. 예를 들어, 2개의 기준 DMR이 이용되는 구현형태에서는 2개의 타영역이 이용되며, 3개의 기준 DMR이 이용되면(도 1 참조) 3개의 타영역이 이용된다.
[72] 명세서의 다른 곳에서도 설명된 바, 본 발명은, 옵션으로 이용된 OR이 본 발명에서 이용된 적어도 하나의 DMR(예를 들어, 기준 DMR)의 게놈의 동일한 부분(예를 들어, DMR의 게놈 위치의 상류 또는 하류로 약 20bp 내지 20kb 사이)에 위치하는 구현형태(DMR의 게놈 위치와 동일한 유전자 내 위치에 위치하는 구현형태도 포함)를 포함한다. 본 발명은, 옵션으로 이용된 OR이 본 발명에서 이용된 적어도 하나의 DMR(예를 들어, 표적 DMR)의 게놈의 동일한 부분(예를 들어, DMR의 게놈 위치의 상류 또는 하류로 약 20bp 내지 20kb 사이)에 위치하는 구현형태(DMR의 게놈 위치와 동일한 유전자 내 위치에 위치하는 구현형태도 포함)를 포함한다. 특정 구현형태에서 OR은 DMR과 겹치지 않는다. 따라서, 다수의 OR이 본 발명에서 이용되는 경우의 구현형태에서는 둘 이상의 OR은 둘 이상의 DMR(예를 들어, 기준 DMR)과 유사하게 게놈에 위치하게 된다. 예를 들어, 전술한 OR 중 하나는 단계 (d)에서 이용되는 기준 DMR의 상류 또는 하류로 약 20bp 내지 20kb 사이에 위치하고(기준 DMR과 동일한 유전자 내에 위치하는 구현형태도 포함됨), 상기 OR의 서로 다른 하나(예를 들어, 제2 OR)는 상기 (예를 들어, 겹치지지 않는) 다른 DMR(예를 들어, 제2 기준 DMR)의 상류 또는 하류로 약 20bp 내지 20kb 사이에 위치한다(제2 기준 DMR과 동일한 유전자 내에 위치하는 구현형태도 포함됨). 특정 구현형태에서, 추가로 이용되는 OR은 DMR(예를 들어, 기준 DMR)과 중첩될 수 있다.
[73] 본 발명에서 이용되는 OR이 DMR(예를 들어, 기준 DMR)의 게놈과 동일한 부분에 위치할 때에, OR이 상기 DMR의 상류 또는 하류로 위치하게 되는 거리는, 약 16kb~20bp, 14kb~20bp, 12kb~20bp, 10kb~20bp, 8kb~20bp, 6kb~20bp, 5kb~20bp, 4kb~20bp, 3kb~2bp, 16kb~20bp, 1kb~20bp, 500bp~20bp, 200bp~20bp, 20kb~15kb, 15kb~10kb, 12kb~8kb, 10kb~8kb, llkb~7kb, llkb~10kb, 9kb~8kb, 8kb~6kb, 6kb~4kb, 4kb~2kb, 2kb~500bp, lkb~100bp, 500bp~50bp, 400bp~200bp, 500bp~100bp, 그리고 500bp~300bp 중에서 선택될 수 있다. 특정 구현형태에서, 이용되는 각 OR은 이용된 DMR(예를 들어, 기준 DMR)과 상이하게 위치하는 것이 일반적이다.
[74] 다수의 OR이 이용되는 경우, 본 발명은 선택적 임의 단계 (f)에서의 검출을 위해 상기 OR 각각에 대해 동일한 검출 표지(들)를 사용하는 구현형태를 포함하고, 그리고/또는 적어도 2개의 표지처리된(표지처리된) 프로브(각각 상기 하나의 OR에 특정됨)를 사용하는 다중 실시간 정량화 PCR을 포함하는 구현형태를 포함한다.
[75] 본 발명 방법의 특정 구현형태에서, 단계 (f)에서의 검출이 수행되는 경우에, 단계 (f)에 적어도 두 개의 OR을 이용하는 것이 포함된다. 특히 이러한 구현형태에서, 상기 OR의 수는 단계 (d)에서 이용된 기준 DMR의 수와 동일할 수 있다. 이 구현형태의 추가 형태로서, 상기 기준 DMR 중의 하나 및 상기 OR 중의 하나는 모두 하나의 기준 염색체(예를 들어, 인간 염색체 5번)에 위치할 수 있고, 제2 기준 DMR 및 제2 기준 OR은 모두 다른 기준 염색체(예를 들어, 인간 염색체 12번)에 위치할 수 있다. 특히 이러한 추가 구현형태에서, 상기 OR의 하나는 단계 (d)에서 이용되는 기준 DMR의 상류 또는 하류에 약 20bp 내지 약 20kb 사이에 위치하며, 상기 OR의 다른 것은 상기 기준 DMR의 상류 또는 하류에 약 20bp 내지 약 20kb 사이에 위치한다.
[76] 본 발명의 구현형태에서, 다양한 DNA 영역, 즉 DMR(들)(및 이용된다면 OR(들)도))의 검출은 단순한 과정으로 수행될 수 있다. 따라서 다양한 DNA 영역들, 즉 DMR(및 이용된다면 OR(들)도)의 검출을 단순한 과정으로 수행할 수 있다는 것이 본 발명의 한 특징이 될 수 있다. 예를 들어, 시료로부터의 DNA의 단일 분취량을 사용하여, 이 DNA 영역을 단일 용기에서 검출할 수 있다. 이러한 특징은 본 방법(들)을 단순화할 수 있고, 더 효율적이고 정확한 검출을 제공할 수 있다(특히 정량적 검출의 구현형태에서). 용어 '용기(vessel)'는 당업계에서 인정되어 있을 것이며, 이 방법에 포함된 공정 또는 절차, 가령 본 발명 방법의 반응 및/또는 검출 과정 또는 단계가 일어나는 용기(튜브, 마이크로타이터 플레이트의 웰, 나노웰, 모세관 반응 용기 등)로 구현된다. 다른 용기로는 오일/물 에멀젼 방울, 나노 입자, 또는 하이브리다이제이션 챔버가 포함될 수 있는데, 이는 이용된 검출 기술에 적절하게 사용된다. 거의 동시에 검출될 때에 기준 DMR(들)에(그리고 이용된다면 OR들에도) 사용되는 검출 표지(들)(detectable label)은 표적 DMR에(이용되는 경우에는 OR에도) 사용되는 표지(들)과 상이하다(즉, 별도로 검출될 수 있다)는 조건 하에서, 본 발명의 특정 구현형태에 사용되는 검출 표지는 각 표적 DMR마다 상이할 수 있고, 그리고/또는 각 기준 DMR마다 동일할 수도 있고/또는 각 OR(포함되는 경우)마다 동일할 수 있다. 대안으로서, 본 발명의 특정 구현형태에서, 사용되는 검출 표지(들)는 각 DMR마다 상이(예를 들어, 동일하지 않음)할 수 있고/있거나 각 OR(포함되는 경우)마다 상이할 수 있다(예를 들어, 동일하지 않음). 표적 DMR(들)에 사용되는 검출 표지(들)가 기준 DMR에 사용되는 표지(들)와 상이하고(즉, 별도로 검출될 수 있고) OR(이용시)에 사용되는 표지(들)와 상이하다는 조건 하에서, 본 발명 방법에서 사용되는 검출 표지는 각 기준 DMR마다 동일할 수 있고, 특정의 구현형태에서는 각 OR(포함되는 경우)마다 동일할 수 있다. 사용된 검출 기술에 의해 크게 차별화될 수 없는바, '동일'한 검출 표지들에는 구조적으로 다르지만 기능적으로(본질적으로) 유사한 표지가 포함될 수 있다. 예를 들어, 구조적으로 상이한 형광 염료는, 여기(excitation) 및 방출(emission) 스펙트럼이 (실질적으로 또는 본질적으로) 유사하거나 동일한 파장(들)(예를 들어, 동일한 파장)으로 동시에 여기 및 검출될 수 있을 정도로 중첩된다면 '동일'하다고 간주할 수 있다. 적절한 표지(및 검출 양상들(modalities))에 대해서는 명세서의 다른 곳에 더 기술되어 있다. 바람직하게는, DMR(들) 및 OR(들)(포함된 경우)의 검출은 유효하게 동시에 수행될 수 있다. 예를 들어, 동일한 (반응/검출) 용기 내에서, 모든 이들 영역(및 그에 따른 전술한 DNA 및 총 DNA 종)을 각각 약 5초, 1초, 0.5초, 100ms, 10ms, 1ms, 100us, 10us, 또는 1us 등보다 짧은 시간 내에 검출할 수 있다(특정적으로는, 각각 약 0.5초 미만, 보다 특정적으로는 약 100ms 미만). 그리고 용기 또는 반응/혼합물을 다른 후속 용기, 분석, 또는 장비로 옮기지 않아도 되는 경우, 또는 DMR(들) 중 하나나 모두 또는 OR(들)별로 검출 프로세스를 별도로 조절하거나 재교정하지 않아도 되는 경우가 그 예이다. 검출 표지(들)의 사용 ― 예를 들어, 상기 제1 표적 DMR(들)에 적어도 하나, 기준 DMR(들)에 적어도 하나 ― 에는 비자연적 성분, 공정, 및/또는 단계를 이용한다. 예를 들어, 특정 DNA 영역을 갖는 두 개의 특정 표지 구성은 (일반적으로) 자연에서는 발견되지 않는 것이다. 특히, 정량적 프로브 기반 PCR에서 사용되는 짧은 프로브는, 하나 이상의 표지(예를 들어, 형광 염료)에 연결될 때, 자연 게놈에서 발견되는 DNA 단편(fragment)인 DNA 서열을 포함할 수는 있지만, 비자연적인 특정 표지가 적용된 단편을 형성한다.
[77] 도면을 통한 설명을 위해, 본 발명의 일 구현형태에 이용된 바와 같은 제1 표적 DMR(들), 기준 DMR들, OR(들)(이용되는 경우), 및 검출 표지(들)의 개괄적인 배치를 도 6에 도시하였다. (la) 염색체 이수성과 관련된 염색체에 위치한 하나의 제1 표적 DMR(DMR1)에서의 DNA 메틸화의 존재가 검출 표지(들)를 사용하여 검출된다. (1b) 염색체 이수성과 관련된 동일한 염색체에 위치한 두 번째 제1 표적 DMR(DMR2)에서의 DNA 메틸화는 다른 검출 표지(들)를 사용하여 검출된다. (1') 두 개의 기준 DMR에서의 DNA 메틸화의 존재는 동일한(단, 제1 표적 DMR을 검출하는 데 사용된 것과는 다른) 검출 표지(들)로 검출된다. (3') 기준 DMR의 검출은, 동일한 검출 표지(들)를 사용하여(그러나 DMR을 검출하기 위해 사용된 것과는 다른) 선택적 임의사항인 두 개의 타영역(OR1 및 OR2)에 연관지어 검출될 수 있다. (2) 상기 OR 중 하나 이상은 기준 DMR과 동일한 염색체에 위치할 수 있다. 특히, (4) OR은 기준 DMR의 게놈의 동일한 부분(예를 들어, 상류 또는 하류로 약 20bp~20kb 사이)에 있을 수 있다.
[78] 본 발명의 맥락에서, 본 발명 방법에서 이용되는 임의의 특정 DMR(예를 들어, 제1 표적 DMR 또는 기준 DMR)에서의 메틸화의 검출은 적어도 하나의 OR에 연관지어 수행될 수 있다. 도면을 통한 설명을 위해, 상기 DMR 검출의 한 구현형태에 이용된 바와 같은 상기 DMR(들), OR(들), 및 검출 표지(들)의 대략적인 배치 개략도가 도 1(a)에 도시되어 있다. (1) DMR1에서의 DNA 메틸화의 존재는 DMR1의 게놈의 동일 부분(예를 들어, 상류 또는 하류로 약 20bp~20kb 사이) 내에 위치한 타영역(OR1)의 맥락에서 검출된다. (2) 선택적 임의사항으로서, 추가 DMR들 및/또는 OR들(예를 들어, DMR2 및/또는 OR2, 그리고 DMRn 및 ORn까지)이 검출될 수 있으며, 이러한 추가 DMR들 및 OR들의 쌍은 서로 게놈의 동일 부분(예를 들어, 상류 또는 하류로 약 20bp~20kb 사이)에 함께 위치할 수 있다. 선택적 임의사항으로서, (3) 다수의 DMR에서의 DNA 메틸화의 존재는 ― 동일한 표적 염색체에 위치하거나 또는 하나 이상의 기준 염색체에 위치할 때 ― 동일한 검출 표지(들)를 사용하여 검출된다. 그리고/또는 (4) 적어도 하나의 OR(OR1)를 이용하여(그리고/또한 옵션으로 OR2, ..., ORn을 이용) 검출된 총 DNA의 양은, DMR(들)에서의 메틸화를 검출하는 데 사용된 것과 상이한 검출 표지(들)를 사용하여 검출된다(선택적 임의사항(옵션)으로서, 사용된 검출 표지(들)는 모든 OR들 ― 동일한 표적 염색체에 위치하거나 하나 이상의 기준 염색체 상에 있을 때 ― 에 대해서 동일하다.
[79] 또한, 본 발명의 맥락에서, 이용된 둘 이상의 DMR(예를 들어, 제1 표적 DMR 또는 기준 DMR)에서의 메틸화는 ― 동일한 표적 염색체에 위치하거나 하나 이상의 기준 염색체에 위치할 때 ― 동일한 검출 표지(들)를 사용하여 검출 가능하다. 도면을 통한 설명을 위해, 상기 DMR 검출의 한 구현형태에 이용된 바와 같은 상기 DMR(들), OR(들)(이용되는 경우), 및 검출 표지(들)의 대략적인 배치 개략도를 도 1(b)에 도시하였다. (1) 두 개 이상의 DMR, DMR1, DMR2(그리고 옵션으로 DMRn까지)에서의 DNA 메틸화는 ― 동일한 표적 염색체에 있거나 하나 이상의 기준 염색체에 위치할 때 ― 각각의 경우에, 동일한 검출 표지(들)로 검출된다. (2) 선택사항으로, 타영역 OR은 DMR 중 하나의 게놈의 동일한 부분(예를 들어, 상류 또는 하류에 약 20bp와 약 20kb 사이)에 위치할 수 있다. (3) 적어도 하나의 OR(OR1)(선택적 임의사항으로서, OR2 또는 ORn까지)을 이용하여 검출된 총 DNA의 양은 DMR에서의 메틸화를 검출하는 데 사용된 것과 다른 검출 표지(들)를 사용하여 검출된다(선택적 임의사항으로서, 사용된 검출 표지(들)는 모두 OR들에 대해서 ― 동일한 표적 염색체에 위치하거나 하나 이상의 기준 염색체에 위치하는 때 ― 동일하다. (4) 선택적 임의사항으로, 2개보다 많은 DMR에서의 메틸화도 상기와 같이 검출되고/또는 총 DNA의 양은 하나보다 많은 OR에서 검출된다.
[80] 본 발명에서 상기 특징들의 조합을 사용하면 효율 개선 및/또는 결과 상승효과(시너지)의 기회를 얻게 된다. 예를 들어, 이러한 조합의 사용에 의해, 전술한 (태아) DNA 종, 특히 기준 염색체의 검출(예를 들어, 정량적 양의 검출) 감도(sensitivity) 및/또는 정확성(accuracy) 및/또는 특정도(specificity) 및/또는 정밀도가 향상될 수 있다. 향상의 정도는 각 특징만 단독으로 사용했을 때와 비교할 때 시너지 효과를 갖는다. 예를 들어, 특징들을 결합하여 얻은 향상은 각 특징을 개별로 사용하여 얻은 각각의 향상 정도의 합보다 크다. 본 발명의 특정 구현형태에서, 분석 또는 검사로부터 이러한 시험에 대해 요구되는 총체적인 감도(참양성 율: true positive rate), 특정도(참음성 율: true negative rate), 및/또는 보고불요 율(non-reportable rate)의 결과를 제공받는다. 예를 들어, 감도는 100%, 거의 100%, 97% 초과(특히 97.5% 초과), 또는 95% 초과이고, 특정도는 95% 초과, 특히 96% 초과이고, 그리고/또는 보고불요 율은 10% 미만(특히 7% 미만), 가령, 6% 또는 5% 미만인 결과가 얻어진다. 특정 구현형태에서, 본 발명의 분석 또는 검사로부터 95% 초과의 감도, 90% 초과의 특정도, 및 10% 미만의 보고불요 율을 얻을 수 있으며, 보다 특정적으로는 97% 초과의 감도, 95% 초과의 특정도, 7% 미만의 보고불요 율을 얻을 수 있다.
[81] 이제 본 발명의 개시에 따라 당업자에게 명백한 바, 이 방법에서는 메틸화를 검출하고, 제2 표적 염색체의 양(예를 들어, 기준 염색체(들)에 상대적인)을 결정/정량화/비교하기 위하여 단계 (c)에 부가하여 이와 유사한 단계가 추가로 수행될 수 있다. 여기서, 제2 표적 염색체도 또한 (예컨대 상이한) 염색체 이수성에 관련된 (예컨대 상이한) 염색체이다. 임신여성이 수태한 태아에서의 두 가지(또는 그 이상) 다른 염색체 이수성의 존재를 검출할 수 있는 이러한 방법은 비용, 속도, 및 편리성의 관점에서 특히 이점을 갖는다.
[82] 따라서, 본 발명의 특정 구현형태에서, 이 방법은 다음의 단계를 더 포함한다.
(c)' 상기 시료에서, 태아의 세포 및/또는 태아의 태반에서 유래한 DNA와 모체 유래 DNA 간에 상이하게 메틸화되고 상기 시약에 의한 제2 표적 DMR의 DNA의 변형은 DNA의 메틸화에 감응하는, 다른 염색체 이수성과 관련된 염색체인 제2 표적 DNA 종의 양을 결정하되, 상기 다른 염색체 이수성에 관련된 염색체에 위치하는 둘 이상의 제2 표적 DMR에 메틸화가 존재하는지를 상기 시료에서 검출함으로써 결정하는 단계;
여기서 상기 제2 표적 DMR 중 하나 이상에서 메틸화된 DNA의 검출량은 상기 시료 내의 상기 제2 표적 DNA 종의 양을 나타냄.
(e)' 단계 (c)'에서 결정된 양과 단계 (d)에서 결정된 양의 상대적 양(들), 바람직하게는 비율(들)을 결정하는 단계;
여기서, 상기 하나 이상의 상대적 양(들)은 태아 내의 다른 염색체 이수성의 존재 또는 부존재를 지시함(indication).
바람직하게는, 상기 단계 (c) 및 단계 (c)' 및 단계 (d)에서의 상기 검출은 상기 시료의 DNA의 동일 분취량(aliquot)을 사용하여, 그리고 동일 용기에서, 그리고 상기 제1 표적 DMR 및 제2 표적 DMR 그리고 상기 기준 DMR에 대해 유효하게 동시에 수행되며, 그리고 옵션사항으로서 (x) 적어도 두 개의 상기 기준 DMR에 대해 동일한 검출 표지(들)를 사용하여서(바람직하게는 각각에 대해 사용) 그리고/또는 (y) 적어도 두 개의 상기 제1 표적 DMR마다(바람직하게는 각각에 대해) 그리고 적어도 두 개의 상기 제2 표적 DMR마다(바람직하게는 각각에 대해), 그리고 선택적 임의사항인 OR(들)마다 상이한 검출 표지를 사용하여서 수행된다.
[83] 제2 표적 DMR과 관련하여, 제2 표적 DMR에 대해 사용된 검출 표지(들)의 여러가지 가능한 설정은 제1 표적 DMR에 대해 기술된 것과 같을 수 있다. 하지만, 특정 구현형태에서는 제1 표적 DMR에 사용되는 것과 기준 DMR에 사용되는 것, 그리고 OR(들)이 이용될 경우에는 이 OR(들)에 이용되는 것과 상이한 검출 표지(들)가 제2 표적 DMR에 사용된다.
[84] 본 발명의 이러한 구현형태에서 임신여성이 수태한 태아에서 둘 이상의 염색체 이수성을 검출하고자 이 방법을 실시할 때, 다른 염색체 이수성에 관련된 염색체는 인간의 21번 염색체, 18번 염색체, 13번 염색체, X 염색체, 및 Y 염색체로 구성된 목록 중 선택된 인간 염색체일 수 있는데, 여기서 특히 이러한 염색체는 제1 표적 염색체와 다른 것이다. 예를 들어, 다른 염색체 이수성에 관련된 염색체는 인간의 18번 염색체 또는 13번 염색체, 특히 인간의 18번 염색체일 수 있는데, 여기서 상기 다른 염색체 이수성은 상기 상이한 염색체의 이수성, 예를 들어 상기 상이한 염색체의 삼염색체이다.
[85] 특히, 본 발명의 이러한 구현형태에서, 임신여성이 수태한 태아에서 둘 이상의 염색체 이수성을 검출하고자 이 방법을 실시할 때, 염색체 이수성에 관련된 상기 염색체 및 다른 염색체 이수성에 관련된 상기 상이한 염색체는 인간의 21번과 18번 염색체, 21번과 13번 염색체, 18번과 13번 염색체로 구성된 목록 중에서 선택된 인간 염색체 쌍일 수 있는데, 여기서 상기 염색체 이수성 및 상기 다른 염색체 이수성은 각 염색체의 이수성, 바람직하게는 각 염색체의 삼염색체이다.
[86] 보다 특히, 본 발명의 이러한 구현형태에서, 임신여성이 수태한 태아에서 둘 이상의 염색체 이수성을 검출하고자 이 방법을 실시할 때, 상기 제1 표적 DMR 각각은 인간의 21번 염색체, 18번 염색체, 또는 13번 염색체 상에, 바람직하게는 21번 염색체에 위치할 수 있고, 선택적 임의사항으로서, 상기 제2 표적 DMR이 있는 경우에 이들 각각은 인간의 18번 염색체 또는 13번 염색체에 위치할 수 있다.
[87] 본 발명은 또한 단계 (c)(및 단계 (e))에 유사한 추가 단계가 더 실시되는 경우를 포함하는데, 이 추가 유사 단계는 다른 염색체 이수성(예를 들어, 2개, 3개, 4개, 또는 그 이상의 염색체 이수성)이 태아에 존재하는지를 지시하기 위해 추가적 표적 DMR을 사용한다. 예를 들어 인간 염색체 21번에서의 이수성을 검출하도록 하나의 단계 (c)(및 단계 (e))를 구성할 수 있으며, 인간 염색체 18번에서 이수성을 검출하도록 제1 추가 단계 (c)(및 단계 (e))를 구성할 수 있으며, 인간 염색체 13번에서 이수성을 검출하도록 제2 추가 단계 (c)(및 단계 (e))를 구성할 수 있다.
[88] 단계 (c)(또는 단계 (e))에 적용 가능한 것으로 명세서에 기술된 모든 구현형태에는, 상기 유사하고 추가적인 단계 (c)(또는 단계 (e)), 예컨대, 단계 (c)'(또는 단계 (e)') 중 어느 것에도 동등하게 적용가능하다. 예를 들어, 단계 (e)'를 갖는 본 발명의 구현형태에서 특히, 본 방법에는 단계 (e)'에서 상기 상대적 양(들) 또는 비율(들)을 임계값(들) 및/또는 기준 분포(들)와 비교하여, 하나 이상의 상기 상대적 양(들) 또는 비율(들)이 상기 임계값(들) 및/또는 기준 분포(들)보다 크거나 낮은 것으로 태아에 다른 염색체 이수성이 존재하는지를 지시하는 것이 추가로 포함될 수 있다.
[89] 특정 구현형태에서, 본 발명의 방법들 중의 단계 (c) 및/또는 단계 (d) 및/또는 옵션 단계 (c)' 및/또는 옵션 단계 (f)의 일부로서 수행되는 검출 단계 이전에 또는 그 일부로서, 각 DNA 영역에는 상기 DMR(들) 및/또는 상기 옵션 OR(들)이 각각 증폭(amplify)된다. DNA의 증폭은 임의의 적합한 복제 과정을 통해 수행될 수 있으며, 특히 이러한 구현형태에서, DMR(들) 및/또는 옵션으로 이용된 OR(들)의 각각은 각 DMR 및/또는 OR에 대해 적절하게 설계된 프라이머를 사용하여 중합 효소 연쇄 반응(PCR)에 의해 증폭된다. 당업자는 본 발명 방법에 사용하기 위한 상기 PCR 프라이머를, 예를 들어 프라이머 설계 알고리즘 및 프로그램(예를 들어, 'Clone Manager Professional 9'(Sci-Ed Software), 'Vector NTI'(Life Technologies), 또는 www.ncbi.nlm.nih.gov/tools/primer-blast/ 또는 molbiol-tools.ca/PCR.htm에 소개된 '웹 기반 툴')을 사용하여 용이하게 설계할 수 있을 것이다. PCR 증폭이 포함된 본 발명의 상기 구현형태는 본 명세서에 기재된 해당 내용과 같은 PCR 실시에 관련된 특정 단계들, 또는 구체적으로는, (A) 이중가닥(double-stranded)의 표적 DNA와 이 DNA의 영역(예를 들어, 본 명세서에 기재된 DMR 또는 옵션으로 이용된 OR)을 증폭하도록 설계된 한 쌍의 프라이머(예를 들어, 본 명세서에 개시된 한 쌍의 프라이머) ― 제1 프라이머는 표적 DNA의 제1 가닥의 서열에 상보적이고 제2 프라이머는 표적 DNA의 제2 가닥, Taq 폴리머라제(Taq polymerase), 및 아데닌 티민 시토신 구아닌을 포함하는 다수의 유리(free) 뉴클레오타이드의 서열에 상보적임 ― 를 포함하는 반응 혼합물을 제공하는 단계; (B) 상기 반응 혼합물을 제1 소정 시간 동안 제1 소정 온도로 가열하여 상기 표적 DNA의 가닥들을 서로 분리시키는 단계; (C) 상기 제1 및 제2 프라이머가 표적 DNA의 제1 및 제2 가닥의 상보적 서열과 하이브리드화(hybridise)되도록 하는 조건 및 상기 Taq 폴리머라제가 프라이머들을 확장하도록 하는 조건 하에서, 상기 반응 혼합물을 제2 소정 시간 동안 제2 소정 온도로 냉각하는 단계; 및 (D) 단계 (B) 및 (C)를 적어도 20 회 반복하는 단계들을 추가로 포함할 수 있다.
[90] 용어 '프로브 기반' 정량화 PCR은 당업계에서 인정된 것이며, 다양한 상표명(예를 들어, Roche의 'TaqMan' PCR)으로 기술되고 출시되는 다양한 구현형태를 포함하며, 특정 앰플리콘(amplicon)(예를 들어, DMR 또는 타영역)의 검출에 특화된 (예를 들어, 형광의) 리포터 프로브(reporter probe)를 사용한다. 프로브 기반 정량화 PCR은, 이중가닥 DNA에 결합하는(binding) 염료(예를 들어, SYBR Green)를 리포터로 사용하는 정량화 PCR과는 구별되는데, 그 이유는 이 이중가닥 DNA 결합 염료는 이중가닥의 앰플리콘에만 특별하게 결합되지 않으며 예를 들어 DMR(들)(즉, 전술한 DNA 종)의 검출과 타영역의 검출(즉, 전체 DNA의 검출)을 구별하는 데 사용할 수 없기 때문이다. 당업자라면 알 수 있듯이, 앰플리콘에 대해 하나의 프로브를 사용하거나 또는 복수의 프로브(예를 들어, 2개 또는 3개의 프로브)를 사용하여 PCR의 특정 앰플리콘을 검출할 수 있다. 특히, 프로브 기반의 정량화 PCR은 어닐링(annealed) 표지처리된(labelled) 올리고뉴클레오타이드(예를 들어, 프로브)를 잡종화 듀플렉스로부터 절단(cleave)하고 표지처리된 올리고뉴클레오타이드 단편을 검출을 위해 방출하기 위하여, 핵산 중합효소의 5' 내지 3' 뉴클레아제 활성을 이용하는 표지처리된 올리고뉴클레오타이드를 사용하여 표적 핵산을 검출하는 프로세스가 통합되어 있는 증폭 반응을 포함할 수 있다. 이러한 접근법 및 프로세스는 당업계에 공지되어 있으며, Gelfand 등(US5804375, EP0543942, 및 관련 패밀리 특허) 및/또는 Livak 등(US6258569, EP 0792374, 및 관련 패밀리 특허)에 의해 더 일반적인 용어로 기술되어 있다. 또한 이러한 접근법 및 프로세스는, 결합(bound)시에 표지의 검출성을 소광하는 소광 분자(quencher molecule)와 검출 표지가 결합된 것이 프로브에 포함되어서, 5' 내지 3' 뉴클레아제(및 그에 따른 증폭)를 발생시킨 다음에 검출 표지가 (소거제로부터 떨어져) 반응 혼합물 내로 방출되어 결과적으로 검출될 수 있도록 하는 것을 포함한다. 또한, '프로브 기반' 정량화 PCR 접근법은 Reed 등의 US6727356, EP1235938, 및 관련 패밀리 특허에 기술된 바와 같은 올리고뉴클레오타이드-형광체-소거제- 마이너 그루브 바인더 접합체(oligonucleotide-flourophore-quencher-minor groove binder conjugates)가 포함된 프로브를 사용함으로써 대안적으로 또는 추가적로 강화될 수 있다. 예시적인 소광 분자는 BHQ1, BHQ3, Eclipse, BHQ2, BBQ650 등이다.
[91] 이러한 프로브 기반의 정량화 PCR은, 신호 강도(예를 들어, 시간 경과에 따른 신호 강도)를 측정하여 정량적으로 검출하는 LightCycler 같은 장치를 사용하여 아날로그 방식으로 실시할 수 있다. 이러한 검출을 위한 시스템 및 접근법은 Woudenberg 등(US6929907, EP0706649, 및 관련 패밀리 특허) 및/또는 Higuchi(US5994056, EP0512334, 및 관련 패밀리 특허)에 기술되어 있다. 대안으로, 디지털 PCR(dPCR), 즉, 검출된 DNA의 양을 정량하는 방법으로서 증폭 이벤트의 수를 판정하기 위한 다중 이벤트로 수행되는 PCR이 제공된다. 예를 들어, 나노웰(nano-well) 또는 드롭플렛(droplet)에서 수행되는 dPCR이 제공된다(ddPCR). 상업적으로 이용 가능한 ddPCR 기술 공급 업체로 Bio-Rad와 Rain Dance가 있다.
[92] 당업자는 DMR 및/또는 OR(들)의 프로브 기반 정량화 PCR 검출을 위해 적절한 프라이머 및 프로브를 (염료와 같은 적절한 표지와 함께) 설계할 수 있을 것이다. 예를 들어 본 명세서의 다른 곳에서 설명한 프라이머/프로브 설계 소프트웨어를 사용하여 설계할 수 있다. 알게 될 바, PCR 프라이머는 이 방법에 사용되는메틸화-특화 변형 시약에 특화된 메틸화 부위(들)와 겹칠 수 있는데, 이는 특히, 시약이 하나 이상의 메틸화 감응성 제한효소(명세서에 기재된 것과 같은 것 또는 그 조합)를 포함할 때에 그러하다. 특히, 이러한 구현형태에서, 주어진 DMR에 대한 PCR 프라이머 중 하나 또는 다른 하나(또는 함께 고려되는 경우에는 둘 다)는 2개 또는 3개의 메틸화 부위(예를 들어, 메틸화 감응성 제한효소별 2개 또는 3개의 제한 부위. 이들 각각에는 메틸화 부위가 포함될 수 있음)와 중첩될 수 있다. 대안으로서 또는 부가적으로, DMR에 대한 프라이머는, 1개, 2개, 3개, 또는 그 이상, 예를 들어, 10, 15, 20, 25, 또는 50개까지의 메틸화 부위를 플랭크(flank)하도록, 특히, 1개, 2개, 3개, 또는 그 이상의(더 구체적으로는 2개~4개의) 메틸화 부위, 예를 들어, 10, 15, 20, 25, 또는 50개까지의 메틸화 감응성 제한효소에 대한 제한 부위(이들 각각에 메틸화 부위가 포함될 수 있음)를 플랭크하도록 설계할 수 있다.
[93] 다른 구현형태에서, 본 발명 방법의 단계 (c) 및/또는 단계 (d) 및/또는 선택적 임의 단계 (c)' 및/또는 선택적 임의 단계 (f)에서 사용되는 검출 표지(들)는, 형광체, 단백질, 소분자, 또는 방사성 표지 중에서 독립적으로 선택된다. 예를 들어, 동일한 형광 표지(유사하거나 겹치는 여기 및/또는 방출 스펙트럼을 갖는 것을 포함)를 DMR에 사용할 수 있고, 여기 및/또는 방출 스펙트럼(특히, 상이한 방출 스펙트럼)을 갖는 형광 표지를 선택이용 OR(들)의 검출에 사용할 수 있다. 당업자는 예를 들어 FAM, TET, JOE, VIC, HEX, NED, PET, ROX, TAMRA, Quasar 및 Texas Red 및 LCCyan500, 6FAM, Cy5, 및 LCRed610 및 LCRed640으로 구성된 군으로부터 본 발명에 사용하기에 적절한 형광 표지를 선택할 수 있을 것이다. 형광 표지는 상응하는 소거제와 함께 사용할 수 있는데, 이러한 표지-소거제 쌍은 당업계에 주지되어 있으며, LCCyan500/BHQ1, Cy5/BHQ3, 6FAM/Eclipse, LCRed610/BBQ650, 및 LCRed640/BHQ3로 구성된 목록으로부터 선택될 수 있다.
[94] 다른 구현형태에서, 검출 표지(들)는 예를 들어 특정 항체 및 ELISA 유형의 검출 접근법을 사용하여 검출할 수 있는 단백질 또는 소분자 태그일 수 있다. 동일한 또는 상이한 표지에 적용 가능한 그리고 다양한 DMR 및/또는 옵션으로 이용된 OR(들)의 검출에 적절한 동일 단백질 또는 소분자 또는 검출가능한 정도로 상이한 단백질 또는 소분자를 또한 검출 표지(들)에 사용할 수 있다. 다른 방사성 표지들은 그들의 방출 에너지, 침투/여기 특성, 및 입자 유형에 의해(예를 들어, 알파 입자와 베타 입자에 의해 구별함)로 구별될 수 있다. 다른 검출 표지(들)(예를 들어, 핵산 코딩된 태그)가 또한 본 발명에 사용될 수 있다.
[95] 본 발명의 특정 구현형태에서, 이 방법의 단계 (c) 및/또는 단계 (c)'에서의 검출은 실시간 정량적 프로브 기반 PCR을 포함하는데, 이는, 예를 들어, 제1 표적 DMR(들) 및/또는 임의의(옵션으로 이용되는) 제2 표적 DMR(들) 중 하나에 특이적인 적어도 하나의 표지처리된 프로브를 사용한다. 다수의 DMR 및/또는 옵션으로 이용되는 OR(들)의 PCR 증폭이 동일한 반응으로 이루어지는 상기 구현형태에서 이러한 PCR은 '다중(multiplex) PCR'로 (또는 단 2개의 DMR 및/또는 OR(들)이 그렇게 증폭된다면 '이중(duplex) PCR'로) 간주될 수 있다. 마찬가지로, 본 발명의 방법에서 단계 (d)에서의 검출에는, 예를 들어 상기 기준 DMR 중 하나에 특이적인 적어도 하나의 표지처리된 프로브를 사용하는 실시간 정량적 프로브 기반 PCR을 부가적으로 또는 대안으로서 포함될 수 있다. 또한 마찬가지로, 본 발명 방법에서 선택적 임의 단계 (f)에서의 검출에는, 예를 들어, 전술한 OR(들) 중 하나에 특이적인 적어도 하나의 표지처리된 프로브를 사용하는 실시간 정량적 프로브 기반 PCR이 부가적으로 또는 대안으로서 포함될 수 있다.
[96] 본 발명 방법에서 사용되는 프라이머 및/또는 프로브는, 예를 들어 메틸화된 CpG를 우라실로 전환시키는 바이설파이트 변환(bisulphite conversion) 후의 서열 특이적 검출시에 하나 이상의 DMR에서 메틸화를 검출하도록 구성 또는 설계할 수 있다. 한정적이지 않은 예로서, 이러한 검출은 본 명세서의 다른 곳에서 기술된 바와 같이 MSP 또는 MethyLight에 의해 실시될 수 있다.
[97] 본 발명의 특정 구현형태에서, 본 발명 방법의 단계 (c)에서의 검출은 예를 들어, 적어도 2개의 표지처리된 프로브(각각 상기 두 개 이상의 제1 표적 DMR의 하나에 특화됨)를 사용하는 실시간 정량적 프로브 기반 PCR을 포함한다. 그리고/또는 상기 단계 (d)에서의 상기 검출은 상기 기준 DMR들 중 하나에 각각 특화된 적어도 2개의 표지처리된 프로브를 사용하는 다중 실시간 프로브에 기반한 정량적 프로브 기반 PCR을 포함한다.
[98] 본 발명의 다른 구현형태에서, 단계 (f)에서의 상기 검출은 상기 OR(들) 중 하나에 특화된 적어도 하나의 표지처리된 프로브를 사용하는 실시간 정량화 PCR을 포함한다.
[99] 둘 이상의 전술한 OR(들)이 이용될 때, 본 발명은 임의(옵션) 단계 (f)에서의 검출이 다음과 같이 이루어지는 구현형태를 포함한다 ― (x) 상기 OR 각각에 대해 동일한 검출 표지(들)를 사용. 그리고/또는 상기 단계 (f)에서의 상기 검출은 상기 OR 중 하나에 각각 특화된 적어도 2개의 표지처리된 프로브를 사용하는 다중 실시간 정량적 프로브 기반 PCR을 포함한다.
[100] 특정 구현형태에서, 다중 정량적 프로브 기반(예를 들어, TaqMan) PCR을 사용하여 하나 이상의(바람직하게는 모두) 검출 단계(즉, DMR(들) 및 OR(들)에 요구되는 단계들)가 하나의 공정 단계 또는 반응으로 효율적이고 유효하게 수행된다. 예를 들어, 본 발명의 특정 구현형태에서, 상기 검출 단계 (c) 및 단계 (d), 그리고 선택적 임의 단계 (c)' 및 선택적 임의 단계 (f)는 상기 시료의 동일한 분취량의 DNA를 사용하여, 동일한 반응/검출 용기에서, 그리고 서로 유효하게 동시에, 그리고 상기 DMR들 및 옵션으로 이용된 OR(들)의 각각에 특화된 적어도 하나의 표지처리된 프로브를 사용하는 다중 실시간 정량화 프로브 기반 PCR에 의해 수행될 수 있다. 특히 이러한 구현형태에서, 시약은 본 명세서에 개시된 바와 같은(또는 이들의 조합) 하나 이상의 메틸화 감응성 제한효소를 포함한다.
[101] 본 발명은 또한 하나 이상의 대조군(control) 절차와 같은 추가적 절차를 포함할 수 있다. 예를 들어, 본 발명은 변형 단계를 위한 대조군(예를 들어, 제한효소 분리(digestion)를 위한 대조군)으로서 작용하는 DNA 영역의 제3 부류의 검출에 관한 하나 이상의 단계를 포함할 수 있다. 이러한 구현형태는, 예를 들어, 이러한 영역 부류에 추가적 검출 표지(들)과 함께 프라이머/프로브(들)의 추가 세트가 사용되어 대조군 영역이 증폭 및 검출되는 다중(멀티플렉스) 실시간 정량적 프로브 기반 PCR을 사용하여 수행될 수 있다.
[102] 본 발명에서, 상기 표적 및 기준 DNA 종은 태아의 세포 및/또는 태아의 태반에서 온 것이고(유래), 상기 시료는 임신여성으로부터 수득된 것이다. 특정 구현형태에서, 시료는 비침습적인 방식으로 수득될 수 있다. 예를 들어, 상기 DNA 종은 채혈관 같은 통상적인 수단에 의해 임신여성으로부터 채취한 혈액 또는 부분혈(혈장 또는 혈청)인 시료로부터 검출된 순환 무세포 DNA(circulating cell-free DNA)이다. 이러한 구현형태에서, 시료는 모체 유래의 DNA를 포함할 수 있는데, 이것은 임신여성의 세포(따라서 임신여성의 게놈)에서 비롯된 것이다.
[103] 본 발명의 모든 양태에는, 시료는 조직 시료 또는 생물학적 유체 시료인 구현형태가 포함된다. 특히, 시료는 전혈 또는 부분혈(예를 들어, 혈장 또는 혈청)이다. 대안적 구현형태에서, 시료는 소변, 타액, 땀, 눈물, 가래, 젖(밀크), 유방 흡인물, 질 분비물, 질 세척물, 및 결장 세척물 중의 군에서 선택된 생물학적 유체이다. 보다 특정적인 구현형태에서, 시료는 임신여성의 혈장 또는 혈청 시료, 또는 임신여성의 소변이다. 다른 구현형태에서, 시료는 세포와 거의(또는 본질적으로) 무관하며, 그리고/또는 전체 혈액(전혈) 시료가 아니다.
[104] 본 발명의 모든 양태의 특정 구현형태에서, 태아의 세포 및/또는 태아의 태반으로부터 유래된 전술한 DNA 종은 순환 무세포 DNA이고 상기 시료는 혈장 또는 혈청과 같은 부분혈이다.
[105] 본 발명은 DMR(예를 들어, 제1 또는 제2 표적 DMR 및/또는 기준 DMR)이 태아 DNA에서 크게 메틸화되고 모체 DNA에서 적게 메틸화된 구현형태를 포함한다. 특정 구현형태에서, 이러한 DMR은 유전자(예를 들어, 본 명세서에 개시된 유전자)의 프로모터(promoter), 인핸서(enhancer) 영역, 또는 엑손(exon)에 위치하거나, 또는 상기 영역 및/또는 유전자로부터의 상류 및/또는 하류에 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치할 수 있다. 대안으로, DMR은 이러한 유전자의 인트론(intron)에, 또는 게놈의 넌코딩 영역에 위치할 수 있다. 본 발명의 모든 양태의 특정 구현형태에서, 상기 게놈 및/또는 유전자는 인간 게놈 또는 유전자이다.
[106] 본 발명은 특히, 상기 DMR(들)에 상기 시약에 특이적인 적어도 하나의, 바람직하게는 적어도 두 개의 메틸화 부위가 포함되는 구현형태를 포함한다. 예를 들어, 상기 시약에 특이적으로 3, 4, 5, 6, 7, 8, 9, 10개, 또는 그 초과, 예를 들어, 약 15, 20, 25, 50개, 또는 그 초과의 메틸화 부위가 포함된다.
[107] 염색체 이수성과 관련된 염색체에 위치한 DMR과 관련하여, 본 발명은 본 명세서에 기술된 것들과 같은 염색체에 위치하는 모든 적절한 DMR을 포함한다.
[108] 본 발명의 특정 구현형태에서, 예를 들어 이 방법을 인간의 21번 염색체의 이수성 검출을 실시하도록 구성할 때, 상기 제1 표적 DMR 및/또는 상기 선택적 제2 표적 DMR은 각각, WO 2011/092592에 개시된 것들 중에서 독립적으로 선택된 영역 및/또는 유전자에 위치한다. 또한 상기 제1 표적 DMR 및/또는 상기 선택적 제2 표적 DMR이 WO 2011/092592의 EP1, EP2, EP3, EP4, EP5, EP6, EP7, EP8, EP9, EP10, EP11, 및 EP12(WO 2011/092592의 서열번호 33~44)에서 선택된 것에 위치하는 것도 포함된다. 더 상세한 연구는 Lim 외 2014, BMC Medical Genomics 7:1에 있다.
[109] 본 발명의 다른 특정 구현형태에서, 상기 제1 표적 DMR 및/또는 상기 선택적인 제2 표적 DMR은 각각, AIRE (ENSG00000160224; 인간의 자가 면역 조절 유전자; Chr21:44,285,838~44,298,648 정방향 가닥(forward strand), GRCh38:CM000683.2), SIM2 (ENSG00000159263; 인간 Single-minded homolog 2; Chr21:36,699,133~36,749,917 정방향 가닥, GRCh38:CM000683.2), 및 ERG (ENSG00000157554; 인간 ETS 관련 유전자; Chr21:38,380,027~38,661,780 역방향 가닥(reverse strand), GRCh38:CM000683.2) 중에서 독립적으로 선택된 영역 및/또는 유전자에 위치하거나, 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치한다.
[110] 본 발명의 다른 특정 구현형태에서, 상기 제1 표적 DMR 및/또는 상기 선택적인 제2 표적 DMR은 각각, 특히 WO 2007/132176에 개시된 PDE9A (ENSG00000160191; 인간 포스포디에스테라제 9A; Chr21:35,887,195~35,887,807 정방향 가닥; GRCh38:CM000683.2), PPP1R2P2 (ENSG00000234008; 인간 단백질 포스파타제 1, 조절성 (억제제) 서브유닛 2 유사유전자 2; Chr21:35,887,195~35,887,807 정방향 가닥, GRCh38:CM000683.2), CBR1 (ENSG00000159228; 인간 카보닐 환원효소 1 유전자; Chr 21:36,069,941~36,073,166 정방향 가닥, GRCh38:CM000683.2), DSCAM (ENSG00000171587; 인간 다운증후군 세포접착분자 유전자; 염색체 21: 40,010,999~40,847,139 역방향 가닥, GRCh38:CM000683), C21orf29 (ENSG00000175894; 인간 트롬보스폰틴형 라미닌 G 도메인 및 EAR 반복 유전자; 염색체 21: 44,497,892~44,711,580 역방향 가닥, GRCh38:CM000683.2), HLCS (ENSG00000159267; 인간 홀로카르복실라제 틴타제 유전자; 염색체 21: 36,750,888~36,990,236 역방향 가닥, GRCh38:CM000683.2) 중에서 독립적으로 선택된 영역 및/또는 유전자에 위치하거나, 또는, 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치한다. 또는, 상기 제1 표적 DMR 및/또는 상기 선택적 제2 표적 DMR은 각각, WO 2007/132176에 개시된 CGI137, 유사성(C.elegans), CGI009, 및 CGI132 중에서 독립적으로 선택된 영역 및/또는 유전자에 위치하거나, 또는, 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치한다. 또는, 상기 제1 표적 DMR 및/또는 상기 선택적 제2 표적 DMR은 각각 C21orf57 (ENSG00000182362; ybeY metallopeptidase; 염색체 21: 46,286,337~46,297,751 정방향 가닥, GRCh38:CM000683.2)인 영역 및/또는 유전자 내에 위치하거나, 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치한다. 또는, 상기 제1 표적 DMR 및/또는 상기 선택적 제2 표적 DMR은 각각 C21orf57 (ENSG00000175894; 염색체 21: 44,497,892~44,711,580 역방향 가닥, GRCh38:CM000683.2)인 영역 및/또는 유전자 내에 위치하거나, 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치한다. 또는, 상기 제1 표적 DMR 및/또는 상기 선택적 제2 표적 DMR은 각각 CGI149 (ENSG00000115561; Charged Multivesicular Body 단백질 3, CHMP3, HGNC:29865; 염색체 2: 86,503,431~86,563,479 역방향 가닥, GRCh38:CM000664.2)인 영역 및/또는 유전자 내에 위치하거나, 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치한다(Chim at al. 2008; Yin 외, 2014; Prenat Diagn 34:63). 이러한 구현형태 중에서 특히, 상기 제1 표적 DMR의 적어도 하나(또는 적어도 하나의 선택적 제2 표적 DMR)는 DSCAM 또는 C21orf57 또는 C21orf29 또는 CGI149에 위치하거나, 또는 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp 를 넘지 않는 DNA 서열에 위치한다. 예를 들어, 상기 제1(또는 선택적인 제2) 표적 DMR들 중 하나는 DSCAM에 위치하고 상기 제1(또는 선택적인 제2) 표적 DMR들 중 다른 것은 C21orf57(또는 C21orf29 또는 CGI149)에 위치할 수 있거나, 또는 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치할 수 있다.
[111] 본 발명의 다른 특정 구현형태에서, 상기 제1 표적 DMR 및/또는 상기 선택적 제2 표적 DMR은 각각, WO 2011/034631의 서열번호(Seq ID No.) 33, 34, 35, 36, 37, 38, 39, 176, 179, 180, 184, 188, 189, 190, 191, 193, 195, 198, 199, 200, 201, 202, 203, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 221, 223, 225, 226, 231, 232, 233, 235, 239, 241, 257, 258, 259, 및 261로 구성된 목록에서 독립적으로 선택된 영역 및/또는 유전자에 위치하는데, 예를 들어, 모체 DNA에 비해 태아 DNA에서 크게 메틸화되는 것으로 특히 WO 2011/034631에 개시된 상기 영역 및/또는 유전자에서의 서열번호 37, 257, 258, 및 259로 이루어진 목록에서 독립적으로 선택된 영역 및/또는 유전자에 위치한다. 본 발명의 상기 특정 구현형태들의 어떤 형태에서는 특히, 상기 제1 표적 DMR 중 하나는 WO 2011/034631의 서열번호 37(본 출원의 서열번호 51)인 영역 및/또는 유전자 내에 위치하고, 상기 제1 표적 DMR 중 다른 것은 WO 2011/034631의 서열번호 258(본 출원의 서열번호 185) 인 영역 및/또는 유전자에 위치하거나, 또는 상기 제1 표적 DMR 중 다른 것은 WO 2011/034631의 서열번호 239(본 출원의 서열번호 182)인 영역 및/또는 유전자에 위치하거나, 또는 상기 제1 표적 DMR 중 다른 것은 영역 및/또는 유전자에 위치한다 WO 2011/034631의 서열번호 39(본 출원의 서열번호 125)인 영역 및/또는 유전자에 위치하거나, 상기 영역 및/또는 유전자로부터 상류 및/또는 하류에 약 100bp, 50bp, 40bp, 30bp, 20bp, 또는 10bp 이내에 위치한다.
[112] 본 발명의 다른 구현형태에서, 예를 들어 이 방법이 인간 18번 염색체 이수성의 검출을 하도록 구성될 때, 상기 제1 표적 DMR 및/또는 상기 선택적 제2 표적 DMR은 각각, VAPA-APCDDI (ENSG00000101558; VAMP(vesicle-associated membrane)에 연계된 단백질 A; 염색체 18: 9,914,002~9,960,021 정방향 가닥, GRCh38:CM000680.2) 및 maspin (ENSG00000206075; 다른 말로 SERPINB5; 세르핀 펩티다제 저해제(serpin peptidase inhibitor), clade B(ovalbumin), member 5; 염색체 18: 63,476,761~63,505,085 정방향 가닥, GRCh38:CM000680.2)으로부터 독립적으로 선택된 영역 및/또는 유전자에 위치하거나, 상기 영역 및/또는 유전자로부터 상류 및/또는 하류에 약 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치한다. 이러한 특정 구현형태에서, 상기 제1 표적 DMR 및/또는 상기 선택적인 제2 표적 DMR은 각각, EP 1 751 307에 태아 및 그 모체 간에 상이하게 메틸화되는 것으로 기재된 maspin(다른 말로 'SERPINB5') 유전자의 영역에 위치하거나, 상기 영역 및/또는 유전자로부터 상류 및/또는 하류에 약 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치한다. 또는 상기 제1 표적 DMR 및/또는 상기 선택적 제2 표적 DMR은 각각, 활성화된 T 세포의 핵 인자, 세포질 1(NFATC1; ENSG00000131196; 염색체 18: 79,395,856~79,529,325 정방향 가닥, GRCh38:CM000680.2)인 영역 및/또는 유전자에 위치하거나, 상기 영역 및/또는 유전자로부터 상류 및/또는 하류에 약 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치한다. 또는, 상기 제1 표적 DMR 및/또는 상기 선택적 제2 표적 DMR은 각각, WO 2011/034631의 chr188r00094인 영역 및/또는 유전자에 위치하거나, 상기 영역 및/또는 유전자로부터 상류 및/또는 하류에 약 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치한다.
[113] 본 발명의 다른 대안적인 구현형태에서, 상기 제1 표적 DMR 및/또는 상기 선택적인 제2 표적 DMR은 각각, WO 2011/034631의 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32(예를 들어, WO 2011/034631의 서열번호 31/본 출원의 서열번호 17, 또는 WO 2011/034631의 서열번호 23/본 출원의 서열번호 9)로 이루어진 목록으로부터 독립적으로 선택된 영역 및/또는 유전자에 위치하거나(여기서 특히, 상기 영역 및/또는 유전자는 WO 2011/034631에 모체 DNA와 비교하여 태아 DNA에서 많이 메틸화(hypermethylate)된 것으로 기재되어 있다), 상기 영역 및/또는 유전자로부터 상류 및/또는 하류에 약 100bp, 50bp, 40bp, 30bp, 20bp, 10bp, 또는 5bp 이내에, 특정적으로는, 상기 영역 및/또는 유전자로부터 상류 및/또는 하류에 20bp 이내에, 더 특정적으로는, 상기 영역 및/또는 유전자로부터 상류 및/또는 하류에 10bp 이내에 위치한다.
[114] 본 발명의 다른 구현형태에서, 예를 들어 이 방법이 인간 13번 염색체 이수성을 검출하도록 구성될 때, 상기 제1 표적 DMR 및/또는 상기 선택적 제2 표적 DMR은 각각, WO 2011/034631의 서열번호 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 및 20으로 이루어진 목록으로부터 독립적으로 선택된 영역 및/또는 유전자에 위치한다. 여기서 특히 상기 영역 및/또는 유전자는 WO 2011/034631에 모체 DNA와 비교하여 태아 DNA에서 많이 메틸화되는 것으로 기재되어 있다.
[115] 기준 염색체에 위치하는 DMR과 관련하여, 본 발명은 본 명세서에 기술된 것과 같이, 상기 염색체에 위치하는 임의의 적합한 DMR을 포함한다.
[116] 본 발명의 특정 구현형태에서, 예를 들어 이 방법이 기준 염색체의 검출을 실시도록 구성되는 경우, 상기 기준 DMR의 적어도 하나는(바람직하게는 상기 기준 DMR의 둘 이상의 각각), RASSDF1A (ENSG00000068028; Ras association(RalGDS/AF-6) 도메인 패밀리 멤버 1; 염색체 3: 50,329,782~50,340,980 역방향 가닥, GRCh38:CM000665.2), TBX3 (ENSG00000135111; T-박스 3; 염색체 12: 114,670,254~114,684,164 역방향 가닥, GRCh38:CM000674.2), CDC42EP1 (ENSG00000128283; CDC42 effector protein(Rho GTPase binding) 1; 염색체 22: 37,560,447~37,569,405 정방향 가닥, GRCh38:CM000684.2), PCDHGA1 (ENSG00000204956; protocadherin gamma subfamily A, 1; 염색체 5: 141,330,571~141,512,981 정방향 가닥, GRCh38:CM000667.2), 및 SPN (ENSG00000197471; salophorin; 염색체 16: 29,662,979~29,670,876 정방향 가닥, GRCh38:CM000678.2)으로 이루어진 목록으로부터 독립적으로 선택된 영역 및/또는 유전자에, 또는 SOX14(ENSG00000168875; SRY (sex determining region Y)-box 14; 염색체 3: 137,764,284~137,766,338 정방향 가닥, GRCh38:CM000665.2) 및 ZFY (ENSG00000067646; zinc finger protein, Y-linked; 염색체 Y: 2,935,281~2,982,506 정방향 가닥, GRCh38:CM000686.2)로부터 선택된 영역 및/또는 유전자에 위치하거나, 또는 상기 영역 및/또는 유전자로부터 상류 및/또는 하류에 약 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치한다. 또는 MGC15523 (ENSG00000157637; 다른 말로 'SLC38A10', 용질 캐리어 계열 A 10; 염색체 17: 81,245,000~81,295,547 역방향 가닥, GRCh38:CM000679.2)에, 또는 상기 영역 및/또는 유전자로부터 상류 및/또는 하류에 약 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치한다. 상기 구현형태들 중에서 특히, 상기 기준 DMR의 적어도 하나는 TBX3 또는 PCDHGA1에 위치하거나, 또는 상기 영역 및/또는 유전자로부터 상류 및/또는 하류에 약 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치하는데, 이는 예를 들어, 상기 기준 DMR의 하나는 TBX3에 위치하고 상기 기준 DMR의 다른 것은 PCDHGA1에 위치하거나 상기 영역 및/또는 유전자로부터 상류 및/또는 하류에 약 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치하는 경우이다.
[117] 본 발명의 다른 특정 구현형태에서, 상기 기준 DMR은 각각, WO 2011/034631의 SEQ ID NO(서열번호) 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 및 163으로 이루어진 목록으로부터 독립적으로 선택된, 예를 들어, WO 2011/034631의 서열번호 52, 118, 및 142로 이루어진 목록으로부터 독립적으로 선택된 영역 및/또는 유전자에 위치하는데, 여기서 특히 상기 영역 및/또는 유전자는 WO 2011/034631에 모체 DNA에 비해 태아 DNA에서 과량 메틸화(hypermethylate)된다고 개시되어 있다. 본 발명의 상기 특정 구현형태들 중 어떤 형태에서, 상기 기준 DMR들의 하나는 WO 2011/034631의 서열번호 52(본 출원의 서열번호 66)인 영역 및/또는 유전자 에 위치하고, 상기 기준 DMR들의 다른 것은 WO 2011/034631의 서열번호 118(본 출원의 서열번호 102)인 영역 및/또는 유전자에 위치한다.
[118] 표 C는 WO 2011/034631 및 WO 2011/092592에서 사용된 서열번호를 본 발명에서 사용된 서열번호로 변환하는 표이다.
[119] 동일한 염색체에 위치하는 2개의 DMR이 이용되는 경우, 본 발명의 모든 양태의 특정 구현형태에서 이들은 게놈 및/또는 유전자의 동일한 부분에 위치하지 않는다. 예를 들어, 이들 DMR은 약 20kb보다 많이, 또는 약 15kb, 10kb, 8kb, 6kb, 4kb, 2kb, 1kb, 500bp, 또는 200bp보다 많이 분리될 수 있다. 이와 달리, 동일한 염색체에 위치하는 2개(또는 그 이상)의 DMR이 본 발명에서 이용될 때, 특정 구현형태에서 이들은 동일한 영역 또는 유전자(본 명세서에 기재된 것과 같은 것)에 위치할 수 있으며, 또한, 서로 중첩될 수도 있다.
표 C: 서열번호(SEQ ID NO) 변환표
Figure pct00003
Figure pct00004
Figure pct00005
Figure pct00006
Figure pct00007
[120] 본 발명의 특정 구현형태에서, 상기 기준 DMR이 2개가 이용되는 경우(또는 2개 이상의 기준 DMR이 이용되는 경우), 상기 기준 DMR의 적어도 하나(바람직하게는 각각)는 RASSF1A 및/또는 TBX3 및/또는 PCDHGA1인 게놈 및/또는 유전자(바람직하게는 인간의)의 부분에, 또는 상기 영역 및/또는 유전자로부터 상류 및/또는 하류에 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치하고, 그리고/또는, 상기 기준 DMR의 적어도 하나(바람직하게는 각각)는 RASSF1A(NCBI 기준 서열: NG_023270.1: Homo sapiens Ras association(RalGDS/AF-6) 도메인 패밀리 멤버 1(RASSF1), 염색체 3의 RefSeqGene; 서열번호 13)의 약 4,700bp 내지 5,600bp의 지점에 위치하고, 그리고/또는 TBX3(NCBI 기준 서열: NG_008315.1: Homo sapiens T-box 3(TBX3), 염색체 12의 RefSeqGene; 서열번호 14)의 약 1,660bp 내지 2,400bp의 지점에 위치하고, 그리고/또는 PCDHGA1(NCBI 기준 서열 Homo sapiens 염색체 5, GRCh38.p2 프라이머리 어셈블리: NC_000005.10 GI:568815593; 서열번호 217)의 141,330,571 내지 141,512,981 사이에, 또는 이 서열의 약 141,492,450 내지 141,492,750 또는 141,492,550 내지 141,492,700 또는 141,492,580 내지 141,492,7690 사이에 위치한다. 보다 더 특정한 구현형태에서, (i) 하나의 기준 DMR은 RASSF1A의 약 4,700bp 내지 5,600bp 사이의 지점에 위치하는 것을 포함하고, 제2의 기준 DMR은 TBX3의 약 1,660bp 내지 2,400bp 사이의 지점에 위치하는 것을 포함한다. 또는 (ii) 하나의 기준 DMR은 PCDHGA1(NCBI 기준 서열 Homo sapiens 염색체 5, GRCh38.p2 프라이머리 어셈블리: NC_000005.10 GI:568815593)의 약 141,492,450 내지 141,492,750 또는 141,492,550 내지 141,492,700 또는 141,492,580 또는 141,492,5690 사이의 지점에 위치하는 것을 포함하고, 제2의 기준 DMR은 TBX3의 약 1,660bp 내지 2,400bp 사이의 지점에 위치하는 것을 포함한다.
[121] 특정 구현형태에서, 기준 DMR은 RASSF1A의 약 4,900bp 내지 5,500bp, 5,000bp 내지 5,400bp, 또는 5,100bp 내지 5,300bp 위치 사이의 RASSF1A에 위치한다. 그리고/또는 TBX3(예를 들어, 서열번호 203)의 약 1,800bp 내지 2,260bp, 1,920bp 내지 2,160bp, 또는 1,920bp 내지 2,080bp 위치 사이의 TBX3에 위치한다. 그리고/또는 대략 40,841,600bp 내지 40,841,900bp, 40,841,625bp 내지 40,841,840bp, 또는 40,841,650bp 내지 40,841,790bp 위치 사이의 DSCAM에 위치한다. 그리고/또는 예를 들어, 서열번호 221의 PCDHGA1다(NCBI 기준 서열 Homo sapiens 염색체 5, GRCh38.p2 프라이머리 어셈블리: NC_000005.10 GI:568815593)의 약 141,492,450 내지 141,492,750, 141,492,550 내지 141,492,700 또는 141,492,585 내지 141,492,690 사이 위치에 위치한다.
[122] 본 발명의 특정 구현형태들에서, 상기 제1(또는 제2) 표적 DMR의 2개가 이용되는 경우(또는 두 개보다 많은 제1 또는 제2 표적 DMR이 이용되는 경우), 상기 제1(또는 제2) 표적 DMR들의 적어도 하나(바람직하게는 각각)는 DSCAM 및/또는 C21orf57인 게놈 및/또는 유전자 부분(바람직하게는 인간의)에, 또는 상기 영역 및/또는 유전자로부터 상류 및/또는 하류에 약 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치한다. 그리고/또는 상기 제1 (또는 제2) 표적 DMR의 적어도 하나(바람직하게는 각각)는 DSCAM(다운증후군 세포 부착 분자; NCBI 기준 서열 Homo sapiens 염색체 21, GRCh38.p2 프라이머리 어셈블리: NC_000021.9 GI:568815577, 영역 40,010,999~40,847,113, 서열번호 200)의 대략 40,841,584 내지 40,842,020 사이 위치에 위치한다. 그리고/또는 C21orf57(YBEY; 염색체 21: 46,286,337~46,297,751 정방향 가닥, GRCh38:CM000683.2; 250bp 상류/하류 lanking 영역을 포함하는 상기 유전자, 서열번호 218)로부터 상류 및/또는 하류에 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp 이내에 위치한다. 그리고/또는 C21orf29(트롬보스폰틴 유형의 라미닌 G 도메인 및 EAR 반복, TSPEARM; HGNC:1268; 염색체 21: 44,497,892~44,711,580 역방향 가닥, GRCh38:CM000683.2)로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp 이내에 위치한다. 그리고/또는 CGI149(charged multivesicular body 단백질 3, CHMP3; HGNC:29865; 염색체 2: 86,503,431~86,563,479 역방향 가닥, GRCh38:CM000664.2)로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp 이내에 위치한다.
[123] 특정 구현형태에서, 제1 (또는 제2) 표적 DMR은, 예를 들어 서열번호 201인 DSCAM(참조: Homo sapiens 염색체 21, GRCh38.p2 프라이머리 어셈블리: NC_000021.9 GI:568815577, 영역)의 약 40,841,600bp 내지 40,841,900bp, 40,841,625bp 내지 40,841,840bp, 또는 40,841,650bp 내지 40,841,790bp 위치 사이에 위치한다. 그리고/또는 C21orf57의 상류 또는 하류로 약 200bp, 150bp, 또는 100bp 이내에 위치하는데, 예를 들어, 서열번호 219와 같은 염색체 21 정방향 가닥 GRCh38:CM000683.2의 약 46,297,700 내지 46,297,940 46,297,750 내지 46,297,900, 또는 46,297,790 내지 46,297,890 이내에 위치한다. 그리고/또는 C21orf29의 상류 또는 하류로 약 200bp, 150bp, 또는 100bp 이내에, 예를 들어, 서열번호 231과 같은 염색체 21 정방향 가닥 GRCh38:CM000683.2의 약 44,709,100 내지 44,709,900, 44,709,300 내지 44,709,700. 또는 44,709,400 내지 44,709,600 위치 사이에 위치한다. 그리고/또는 CGI149의 상류 또는 하류로 약 200bp, 150bp, 또는 100bp 이내에, 예를 들어, 서열번호 232와 같은 염색체 21 정방향 가닥, GRCh38:CM000683.2의 약 46,667,100 내지 46,667,950, 46,667,300 내지 46,667,750, 또는 46,667,400 내지 46,667,650 위치 사이에 위치한다.
[124] 하나의 한정적이지 않은 예를 들면, 본 발명의 일 구현형태에서,(i) 상기 제1 표적 DMR들의 하나는 DSCAM에 위치되고 제1 표적 DMR들의 다른 것은 C21orf57(또는 C21orf29 또는 CGI149)에, 또는 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp을 넘지 않는 DNA 서열에 위치하고, (ⅱ) 상기 기준 DMR들 중 하나는 TBX3에 위치하고 상기 기준 DMR 중 다른 것은 PCDHGA1에, 또는 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp을 넘지 않는 DNA 서열에 위치한다. 상기 구현형태에서는 특히, (i) 상기 제1 표적 DMR 중 하나는 서열번호 201을 포함하고, 상기 제1 표적 DMR 중 다른 것은 서열번호 219(또는 서열번호 231 또는 232)를 포함하며, (ii) 상기 기준 DMR 중 하나는 서열번호 203을 포함하고 상기 기준 DMR 중 다른 것은 서열번호 220을 포함한다.
[125] 실시예 1에서 이용된 상이한 메틸화 기반의 DNA 검출의 DMR 및 타영역 OR 의 개괄적인 배열을 도 2에 나타내었다. (1a) DMR1은 RASSF1A의 엑손(exon) 2에서 발견되며 OR1은 RASS1A의 엑손 4에 위치하는데, 여기서 DMR1은 50,340,672bp 내지 50,340,784bp 사이에 위치하고 OR1은 RASSF1A 게놈 서열(NCBI 기준 서열: NC_000003.12 Homo sapiens 염색체 3, GRCh38 프라이머리 어셈블리)의 50,331,604bp 내지 50,331,702bp 위치 사이에 위치한다. OR1 및 DMR1의 이격 거리는 8,969bp이다. (lb) DMR2는 TBX3의 프로모터(promoter) 영역에서 발견되는바 114,687,095bp 내지 114,687,189bp 사이에 위치하며, OR2는 TBX3 게놈 서열(NCBI 기준 서열: NC_000012.12 Homo sapiens 염색체 12, GRCh38 프라이머리 어셈블리)의 114,676,384bp 내지 114,676,454bp 위치 사이에 위치하며, DMR2와 OR2는 10,640bp의 거리만큼 떨어져 있다. (2) 2개의 DMR에서 DNA 메틸화는, 각각 정방향(F) 및 역방향(R)의 PCR 프라이머 및 영역특화 프로브를 써서 프로브 기반 정량화 PCR을 사용하여 검출된다. 각 프로브는 동일한 표지(P*)로 표지처리된다. (3) 2개의 OR에서 총 DNA는, 각각의 순방향(F) 및 역방향(R)의 PCR 프라이머와 영역특화 프로브를 써서 프로브 기반 정량화 PCR을 사용하여 검출된다. 각 프로브는 OR에 대해 동일한 표지(P**)로 표지처리되는데, 이는 두 DMR에 사용된 표지와 다른 표지이다. 프라이머와 프로브 서열 그리고 프로브 표지의 세부 사항은 표 1에 제시되어 있다.
[126] 본 발명의 비한정적인 구현형태에 이용되는 DMR 및 타영역(OR)의 개괄적 배치가 도 6에 도시되어 있다. (1a) 하나의 제1 표적 DMR(DMR1)은 예를 들어 서열번호 51에 위치하는 것과 같은 예컨대 DSCAM(다운증후군 세포 부착 분자; NCBI 기준 서열 Homo sapiens 염색체 21, GRCh38.p2 프라이머리 어셈블리: NC_000021.9 GI:568815577, 영역 40,010,999 내지 40,847,113, 서열번호 200)에서 발견되고, (lb) 다른 제1 표적 DMR(DMR2)은 예를 들어 서열번호 185에 위치하는 것과 같은 예컨대 C21orf57(YBEY; 염색체 21: 46,286,337~46,297,751 정방향 가닥, GRCh38:CM000683.2; 250bp 상류/하류 flaking 영역을 포함하는 상기 유전자, 서열번호 218)의 상류 또는 하류로 250bp를 넘지 않는 영역에서 발견된다. (1') 제1 기준 DMR(DMR1')은 TBX3(예를 들어, 서열번호 66에 위치하는)의 프로모터 영역에서 발견되고, OR1'은 TBX3(인간 염색체 12)에 위치하는데(2a'), 여기서 DMR1'은 114,687,093bp 내지 114,687,191bp 위치 사이에 위치하고 OR1'은 TBX3 게놈 서열(NCBI 기준 서열: NC_000012.12 Homo sapiens 염색체 12, GRCh38 프라이머리 어셈블리)의 114,676,384bp 내지 114,676,454의 위치 사이에 위치한다. DMR1'과 OR1'은 약 10,600bp 내지 10,810bp의 거리만큼 이격된다(4a'). 그리고 제2 기준 DMR(DMR2')은 PCDHGA1(예를 들어, 서열번호 102에 위치)에서 발견되며, OR2'는 PCDHGA1(인간 염색체 5)에 위치하는데(2b'), 여기서 DMR2'는 위치 141,492,593~141,492,687 사이에 위치하고 OR2'는 PCDHGA1 게놈 서열(NCBI 기준 서열 Homo sapiens 염색체 5, GRCh38.p2 프라이머리 어셈블리: NC_000005.10 GI:568815593)의 141,492,918~141,493,009 위치 사이에 위치하고, DMR2'과 OR2'은 300pb의 거리로 이격된다(4b'). 이와 달리, (1a) DMRl 및/또는 (1b) DMR2는, (x) 예를 들어 서열번호 231에 위치하는 것과 같은 예컨대 C21orf29(TSPEARM; HGNC: 1268; 염색체 21: 44,497,892~44,711,580 역방향 가닥, GRCh38:CM000683.2)의 상류 또는 하류로 250pb를 넘지 않는 영역, 또는 (y) 예를 들어 예를 들어, 서열번호 232에 위치하는 것과 같은 예컨대 CGI149(CHMP3; HGNC:29865; 염색체 2: 86,503,431~86,563,479 역방향 가닥, GRCh38:CM000664.2)의 상류 또는 하류로 250pb를 넘지 않는 영역에서 발견될 수 있다.
[127] 도 6에 도시한 본 발명의 구현형태에서, 두 개의 제1 표적 DMR의 각각은 상이한 검출 표지(들) (1a) 및 (1b)로 검출되고, 2개의 기준 DRM(DRM1' 및 DMR 2')은 동일한 검출 표지(들) (1')로 검출되고, 선택적으로 이용된 2개의 OR(OR1' 및 OR2')은 동일한 검출 표지(들)(3')로 검출된다.
[128] 본 발명의 특정 구현형태는, 방법, 조성물, 키트(또는 그 구성품), 및/또는 이들의 컴퓨터 프로그램 제품의 맥락에서, 특히 표 1, 표 D 또는 표 5, 또는 표 E, 표 8 또는 표 10에 제시된 하나 이상의 전술한 DMR, OR, 프라이머의 서열, 및/또는 프로브를 포함하거나 이들의 사용을 포함한다. 상기 구현형태의 특정한 형태로, 소정의 프로브는 표 1, 표 D 또는 표 5, 또는 표 E, 표 8 또는 표 10에 기재된 서열을 포함하고, 표 1, 표 D 또는 표 5, 또는 표 E, 표 8 또는 표 10에 기재된 것과 같은 표지(label) 및 소거제(quencher) 쌍 중 어느 하나를 포함한다(선택적 임의사항으로, minor binding groove moiety를 부가). 특히, 프로브는 표 1, 표 D 또는 표 5, 또는 표 E, 표 8 또는 표 10에 제시된 바와 같은 표지와 표지-소거제 쌍(선택적 임의사항으로, minor binding groove moiety를 부가함)을 갖는 서열의 조합을 포함할 수 있다. 본 발명의 다른 구현형태는, 특히 방법, 조성물, 키트(또는 그 구성품), 및/또는 이들을 위한 컴퓨터 프로그램 제품의 맥락에서, 둘 이상의(예를 들어 모든) 전술한 DMR, OR, 프라이머의 서열, 및/또는 프로브의 특정한 조합, 특히, 표D의 프라이머 또는 프로브를 포함하여 표 1에 기재된 바와 같은 프라이머/프로브의 조합 및/또는 표 5에 제시된 바와 같은 프라이머/프로브의 조합, 보다 구체적으로는, 분석 버전 V10.3에 대한 표 E에 기재된 바와 같은 프라이머/프로브의 조합을 포함하거나 이들 조합의 사용을 포함한다. .
[129] '메틸화 부위(methylation site)'라는 용어는 당업계에서 인정될 것이며, 예를 들어 본원의 다른 곳에 개시된 것과 같이 메틸화 감응성 제한효소에 의해 인식되는 것이 바람직한 짧은 염기 서열(예를 들어, 길이가 4, 6, 8, 10, 또는 12bp 인 것) 내의 CpG 모티프(motif)를 포함하는 의미를 갖는다
[130] 이와 유사하게, 특히, 하나 이상의 OR을 이용하는 본 발명의 구현형태의 맥락에서, OR이 게놈의 특정 부분 및/또는 유전자에 위치할 경우 이 OR은 유전자의 프로모터, 인핸서 영역, 또는 엑손에 위치할 수 있고, 또는 이와 달리 이러한 유전자의 인트론에 또는 게놈의 비암호화(넌코딩) 영역에 위치할 수 있다. 본 발명의 모든 양태의 특정 구현형태에서, 상기 게놈 및/또는 유전자는 인간의 게놈 또는 유전자이다. 특정 구현형태에서, OR이 본 발명에서 이용되고 하나 이상의 DMR을 특징짓는 게놈 및/또는 유전자의 동일한 부분에(바람직하게는 본 발명에서 이용되는 DMR과 중첩되지 않게) 위치하는 경우에, 그것이 위치하는 게놈 및/또는 유전자의 부분은, RASSF1A 및/또는 TBX3 및/또는 PCDHGA1인 유전자(예를 들어 인간 및/또는 특히 상기 DNA 종이 태아 cfDNA인 경우) 또는 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열, 또는 RASSF1A, TBX3, HLCS, ZFY, CDC42EP1, PCDHGA1, MGC15523, SOX14, 및 SPN 및 DSCAM 및 C21orf57 및 C21orf29 및 CGI149 또는 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열로 이루어진 군으로부터 선택되는 것을 예로 들 수 있다. 타영역이 DMR과 함께 위치하지 않을 때(예를 들어, 제2 또는 다수의 타영역이 이용될 때), 특정 구현형태에서 타영역은 (예를 들어, 인간의) 하우스키핑 유전자(예를 들어, GAPDH, 베타-액틴, ALB, APOE, 또는 RNASEP)에 위치할 수 있다. 이와 유사하게, 특히 하나 이상의 OR을 이용하는 본 발명의 다른 구현형태의 맥락에서, OR은 게놈의 특정 부분 및/또는 유전자에 위치할 수 있으며, 유전자의 프로모터, 인핸서 영역, 또는 엑손에 위치할 수 있고, 또는 이와 달리 이러한 유전자의 인트론에 또는 게놈의 비암호화(넌코딩) 영역에 위치할 수 있다. 본 발명의 모든 양태의 특정 구현형태에서, 상기 게놈 및/또는 유전자는 인간의 게놈 또는 유전자이다. 특정 구현형태에서, 본 발명에 이용되는 OR은 (예를 들어, 인간의) 하우스키핑 유전자(GAPDH, 베타-액틴, ALB, APOE, 또는 RNASEP) 또는 상기 영역 및/또는 유전자의 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치할 수 있다. 이와 달리, 상기 OR은 하나 이상의 DMR을 특징짓는 게놈 및/또는 유전자의 동일한 부분(예를 들어, RASSF1A, TBX3, HLCS, ZFY, CDC42EP1, PCDHGA1, MGC15523, SOX14, 또는 SPN 또는 DSCAM 또는 PCDHGA1 또는 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열)에 위치할 수 있고, 본 발명에 이용된 DMR과 중첩되지 않는 것이 바람직하다.
[131] 하나 이상의 OR을 이용하는 본 발명의 모든 양태의 특정 구현형태에서, 상기 OR은 상기 시약(reagent)에 특이적인 메틸화 부위가 없는 게놈 부분을 포함하고, 상기 OR은 (예를 들어 인간의) 유전자 RASSF1A 또는 TBX(예를 들어, 각각 서열번호 13 및 14) 또는 DSCAM(서열번호 200) 또는 PCDHGA1(서열번호 217) 또는 C21orf57(서열번호 218, 250bp 상류/하류 flaking 영역을 포함하는 유전자) 또는 C21orf29 또는 CGI149 또는 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열에 위치한다. 그리고 둘 이상의 상기 타영역이 검출 단계 (c)에서 이용되고, 제1 의 타영역은 상기 RASSF1A의 약 14,220bp 내지 13,350bp 사이에 위치하고, 제2의 타영역은 상기 TBX3의 약 12,400bp 내지 13,000bp 사이에 위치하는 보다 특정적인 구현형태가 포함된다. 특정 구현형태에서, 타영역은 RASSF1A에 약 14,230bp 내지 14,340bp, 14,230bp 내지 14,330bp, 14,230bp 내지 14,320bp, 또는 14,230bp 내지 14,310bp 사이의 위치에 위치한다. 그리고/또는 상기 TBX3(예를 들어, 서열번호 204)에 약 12,400bp 내지 12,940bp, 12,700bp 내지 12,850bp 또는 12,710bp 내지 12,790bp 위치 사이에 TBX3에 위치한다. 그리고/또는 예를 들어 서열번호 202와 같은 DSCAM(Homo sapiens 염색체 21, GRCh38.p2 프라이머리 어셈블리: NC_000021.9 GI:568815577, 영역)의 약 40,841,150bp 내지 40,841,525bp, 40,841,200bp 내지 40,841,475bp 또는 40,841,250bp 내지 40,841,425bp 위치 사이의 DSCAM에 위치한다. 그리고/또는 예를 들어 서열번호 221와 같은 PCDHGA1(NCBI 기준 서열 Homo sapiens 염색체 5, GRCh38.p2 프라이머리 어셈블리: NC_000005.10)의 141,492,800 내지 141,493,100, 141,492,850 내지 141,493,050, 141,492,900 내지 141,493,020, 141,492,918 내지 141,493,009 위치 사이의 PCDHGA1에 위치한다. 이와 달리, OR는 예를 들어, 상기 RASSF1A의 약 13,790bp 내지 13,880bp 또는 14,490bp 내지 14,600bp 위치 사이, 또는 상기 TBX3의 약 8,040bp 내지 8,180bp 또는 6,230bp 내지 6,350bp 위치 사이의 엑손에 위치할 수 있다. 또는 OR은 예를 들어 상기 RASSF1A의 약 10,500bp 내지 11,90bp 사이의, 또는 상기 TBX3의 약 10,000bp 내지 11,000bp 사이의 인트론에 위치할 수 있다. 이와 달리, OR은 예를 들어 아래 서열
Figure pct00008
와 같이 DSCAM에 위치할 수 있는데, 위 서열은 아래와 같은 프로브 및 프라이머로 증폭 및 검출될 수 있다.
표 D: DSCAM 타영역(OR)을 위한 프라이머 및 프로브
Figure pct00009
* 염료/소거제 없이 뉴클레오티드 서열만 제시함
** 각 프로브에 사용된 염료/소거제는 '[ ]' 안에 표시함
표 E: 실시예 10의 분석법의 시연을 위해 사용된 프라이머 및 프로브
Figure pct00010
Figure pct00011
Figure pct00012
* 염료/소거제 없이 뉴클레오티드 서열만 제시함
** 각 프로브에 사용된 염료/소거제는 '[ ]' 안에 표시함
[132] 현재 임신여성의 순환물(예를 들어, 혈장)에 존재하는 태아 cfDNA(및/또는 총 cfDNA)의 레벨은 조기발병 자간전증(preeclampsia), 경증 및/또는 중증의 자간전증과 같은 한 가지 이상 형태의 자간전증에 대한 지표(marker)라는 강력한 증거가 있다(Hahn 외 2011, Placenta 32(Supl):S17 참조). 본 발명은 임신여성의 혈장에 존재하는 태아 cfDNA의 효율적이며 유효하고 감도가 높고 그리고/또는 변동성이 적은 검출/정량화에 특별한 유용성을 보여 주며, 본 발명은 이에 대한 특별한 유용성을 갖는다. 따라서, 본 발명의 특정 구현형태에서, 개체는 임신과 관련된 의학적 증상을 앓고 있는 데 대한 또는 그 발병에 대한 감수성이 있는(susceptible to) 임신여성(예를 들어, 인간)이다. 특히 여기서 상기 임신과 관련된 의학적 증상은 자간전증이다. 본 명세서에서, 의학적 증상에 '감수성이 있는(susceptible to)' 개체는, 의학적 증상을 앓고 있는 것으로 또는 발병될 것으로 '의심이 간다(is suspected to) 또는 의학적 증상을 앓고 있는 또는 그 발병의 '위험에 처해 있는 것으로 간주된다'로 다르게 표현할 수 있다. 그리고 특정 구현형태에서, 본 발명은 의학적 증상에 대한 감수성이 있는 개체, 또는 의학적 증상을 앓고 있는 또는 발병할 위험이 있는 개체, 또는 의학적 증상을 앓고 있거나 발병될 개체를 선별 및/또는 진단하는 데 이용된다.
[133] 대안적인 구현형태에서, 개체는 조기 진통(preterm labor), 자궁내 성장 지연(intratererine growth retardation), 그리고 쌍태아 소실(vanishing twin) 중에서 선택된 임신관련 의학적 증상을 겪는 데에 또는 그 발병에 감수성이 있는(또는 이러한 위험에 처해 있는 것으로 간주되는) 임신여성(예를 들어, 인간)이다. 특히, 실시예 1과 비교하면, 본 발명의 감도(sensitivity)는, 본 발명 방법에 의해 결정된 cfDNA 레벨과 대용량 병렬처리 시퀀싱법에 의해 결정된 Y 염색체 서열 카운트 사이의 불일치가, 쌍태아 임신(혼합 성별)시 과거에는 단생아 임신으로 여겨졌었던 쌍태아소멸의 한 가지 이상의 사례를 식별하는 데에 그리고/또는 이러한 (혼합 성별) 쌍태아 임신시의 쌍태아들의 상대적 발달 및 건강을 추적하는 데에 유용하도록 한다. 본 발명은 또한, cfDNA로부터 결정된 Y 염색체 서열의 카운트 대비, 태아 cfDNA의 상대 값을 고려함으로써(예를 들어, 병렬처리 시퀀싱법을 이용) 쌍태 임신의 성별 결정에 이용될 수 있다. 이와 관련하여, 모체 혈액에서 무작위 cfDNA 대규모 병렬처리 시퀀싱을 이용하는 접근법은 일반적으로 항상, 특정 Y 염색체의 짧은 서열의 다른 염색체에 대한 상동성(homology) 때문에 모든 여성 임신부에 있는 'Y 염색체' 서열의 매우 낮은 빈도를 계산한다(예를 들어, 모든 서열의 약 0.003% 내지 0.004%, 또는 모든 서열의 약 0.0015% 내지 0.01% 또는 0.002% 내지 0.005%). 그러므로, 여성 시료에 대해서 'Y 염색체' 서열 카운트를 약 0.005%, 또는 약 0.003%, 0.004%, 0.006%, 또는 0.007% 사이로 컷오프할 수 있다.
[134] 본 발명의 모든 양태에서, 메틸화 DNA 및 비메틸화 DNA를 상이하게 변형시키는 시약(reagent)은 바이설파이트(bisulphite) 및/또는 메틸화 DNA보다 비메틸화 DNA를 선택적으로 분해(digest)시키는 제제를 포함할 수 있다(예를 들어, 이 제제는 비메틸화 DNA는 분해시킬 수 있으나 메틸화 DNA는 분해시킬 수 없음). 특정 구현형태에서, 이 시약은, 적어도 하나의 메틸화 감응성 효소; 적어도 하나의 메틸화 감응성 제한효소; 그리고/또는 AatII, AciI, AclI, AfeI, AgeI, AgeI-HF, AscI, AsiSI, AvaI, BceAI, BmgBI, BsaAI, BsaHI, BsiEI, BsiWI, BsmBI, BspDI, BsrFI, BssHII, BstBI, BstUI, ClaI, EagI, FauI, FseI, FspI, HaeII, HgaI, HhaI, HinPlI, HpaI, Hpy99I, HpyCH4IV, KasI, MluI, NaeI, NarI, NgoMIV, NotI, NotI-HF, NruI, Nt.BsmAI, Nt.CviPII, PaeR7I, PluTI, PmlI, PvuI, PvuI-HF, RsrII, SacII, SalI, SalI-HF, SfoI, SgrAI, SmaI, SnaBI, TspMI 및 ZraI, 및 Cac8I 및 PhoI로 이루어진 군에서 선택된 제제를 포함할 수 있다. 특정 구현형태에서, 상기 시약은 BstUI, HhaI 및 HpaII 및 AciI로 이루어진 군으로부터 선택된다.
[135] 관련된 구현형태에서, 시약은 본 명세서에 개시된 임의의 2개 이상의 시약을 포함할 수 있다. 예를 들어, BstUI, HhaI, 및 HpaII로 구성된 그룹에서 선택된 2개 또는 3개의 메틸화 감응성 제한효소를 포함(comprising)하거나 필수적으로 이들로써 구성되는(essentially consisting) 시약을 포함하여 2개, 3개, 4개, 5개, 또는 그 이상의(예를 들어, 7개, 8개, 또는 10개까지) 메틸화 감응성 제한효소를 포함할 수 있다.
[136] 상이한 메틸화를 연구하기 위한 바이설파이트 또는 메틸화 감응성 제한효소의 용도는 표준 교과서의 교시 또는 Poon 외(2002), Nygren 외(2010), 또는 Yegnasubramanian 외(2006, Nuc Acid Res 34:el9)과 같은 공개된 방법을 적용할 수 있는 당업자가 잘 알 것이다. 본 발명자들은 메틸화 및 비메틸화 DNA를 상이하게 변형시키는 시약으로서 메틸화 감응성 제한효소를 사용하는 예를 여기서 설명하여 제공한다. 바이설파이트를 시약으로서 사용하는 추가적 설명의 경우에, 예를 들어 바이설파이트에 의해 변형되는 DNA 메틸화 부위를, 예를 들어 메틸화 특이적(methylation-specific) PCR을 사용하여(예를 들어, 바이설파이트에 의해 변형된 서열에 선택적으로 결합하는 프라이머 및/또는 프로브를 사용하여) 그리고/또는 후속으로 제한효소를 사용하여서(그 인식 부위(recognition site)는 상기 바이설파이트에 의한 변형시에 생성됨) 검출할 수 있다는 것은 당업자에게 명백할 것이다. 메틸화 특이적 PCR('MSP')은 Herman 등(US6200756, EP0954608, 및 관련 패밀리 특허)에 기술되어 있고, 프로브 기반 PCR을 이용한 MSP('메틸라이트(MethylLight)'로 알려져 있음)의 추가 개발은 Laird 등(US6331393, EP1185695, 및 관련 패밀리 특허)에 기술되어 있다.
[137] 본 발명의 모든 양태의 특정 구현형태에서, 제1 또는 제2 DNA 종 및/또는 기준 DNA 종 (및/또는 상기 총 DNA)의 정량적 양(amount)을 검출 및/또는 결정해야 한다. 따라서, 이러한 구현형태에서, 상기 검출 및/또는 결정 단계 중 하나 이상(예를 들어, 각각)에는 정량적 검출 단계가 포함되고, 상기 DNA 종의 검출량은 상기 시료에 존재하는 총 DNA 대비 상기 DNA 종들의 상대 농도로서 표시된다. 예를 들어, 본 발명의 특정 구현형태에서, 전술한 각각의 결정 단계에서, 상기 제1 표적 DNA 종의 상기 결정된 양 및 상기 선택적인 제2 표적 DNA 종의 상기 결정된 양의 각각은, 상기 시료 내의 총 DNA에 대한 상기 제1 표적 DNA 종의 상대 농도 그리고 총 DNA에 대한 상기 선택적인 제2 표적 DNA 종의 상대 농도로 표시된다. 제3(또는 제4) 표적 DNA 종을 검출하는 구현형태에서도 본 발명은 또한 제3(또는 제4) 표적종 DNA의 양을 상대 농도로 표시한다.
[138] 총 DNA의 절대적 양을 안다면 이에 따라 상기 상대 농도로부터 임의의 DNA 종의 절대적 양(예를 들어, μg/mL와 같은 농도로 또는 Eg/mL와 같은 게놈 등가물로 나타냄)을 결정할 수 있다. 특정 구현형태의 경우에, 단계 (c)에서 이용된 것과 동일한 타영역(들)을 이용하여, DNA 양을 알고 있는 표준 시료에서 총 DNA의 양을 검출 및/또는 결정하는 단계; 그리고 상기 표준 DNA 시료로부터 검출된 신호를 단계 (c)에서 검출된 신호와 비교하는 단계를 추가로 포함함으로써, 시료에 대한 총 DNA의 절대적 양을 결정할 수 있다. 이러한 표준 DNA 시료(양/농도를 알고 있음)는 상업적으로 쉽게 구할 수 있으며, 특히 딜루션 시리즈(dilution series)를 사용하여 준비하고 분석한다면 시료에 존재하는 총 DNA의 절대적 양을 (표준 곡선으로부터의 보간/추정에 의해서) 결정하는 데 용이하고 효율적으로 사용할 수 있다. 실제적으로, 이러한 표준 곡선은 선택적 임의사항인 OR에 대해 설명한 것처럼 실질적으로 준비 및 분석할 수 있는데, 이는 DMRs/OR(들)의 검출과 동일한 실행(run)으로(그러나 별개의 표준 용기/반응 세트에서) 행하는 것이 바람직하며, 동일한 반응 마스터믹스(reaction master-mix)를 사용할 수도 있다. 따라서, DNA 대조군의 'DMR(들)'은 상기 표준 DNA에 대해 검출할 수 있지만, 상기 신호는 표준 곡선을 생성하는 데 필요하지 않다. 따라서, 이러한 표준 DNA 시료로부터의 신호를 사용하여 비교하는 경우, 상기 각각의 검출 및/또는 결정 단계에 정량적 검출 단계가 포함되는 특정 구현형태에서는, 상기 DNA 종의 상기 검출량을 상기 시료에 있는 상기 DNA 종들의 절대적 양으로 표시할 수 있게 된다.
[139] 따라서, 본 발명 방법의 일 구현형태에는 다음과 같은 단계들이 추가로 포함된다.
- 단계 (c) 및/또는 단계 (d), 그리고/또는 선택적 임의 단계 (c)' 및/또는 선택적 임의 단계 (f)에서 이용된 동일한 DMR에 대해서, 양을 알고 있는 표준 DNA 시료에서의 DNA 양을 결정하는 단계; 그리고
- 상기 표준 DNA 시료로부터 검출된 각 신호를 단계 (c) 및/또는 단계 (d), 그리고/또는 선택적 임의 단계 (c)' 및/또는 선택적 임의 단계 (f)에서 검출된 각 신호와 비교하는 단계.
[140] 표준 DNA 시료를 활용하는 본 발명의 모든 구현형태들에는, 이 표준 DNA 시료는 기지(알고 있는) 농도의 인간 게놈 DNA 시료인 특정 구현형태가 포함된다. 예를 들어, 이러한 기지 농도의 인간 게놈 DNA는 염색체의 정배수체(euploid) 또는 이수성(aneuploidy)(예를 들어, T21) 보체(complement) 중 하나를 갖는 것으로 알려진 것같은 체외 배양된 인간 세포로부터 얻어진다(예를 들어, 분리 또는 정제). 본 발명의 다른 구현형태에서, 표준 DNA 시료는 합성(synthetic) 또는 가공(engineered)된 기지 농도의 DNA 시료이다.
[141] 당업자에게 명백한 바, 표준 DNA 시료는 (특히 인간 세포 배양으로부터 분리된 경우) 균일하게, 적절하게, 상이하게, 또는 달리 메틸화되지 않을 수 있다. 따라서, 본 발명은 메틸화 및 비메틸화 DNA를 상이하게 변형시키는 시약(본 명세서에 기재된 시약과 같은)으로 표준 DNA 시료를 처리하지 않는 구현형태를 포함한다.
[142] 본 발명의 하나의 특정 구현형태에서, 상기 각 결정 단계에서, 상기 제1 표적 DNA 종 및 상기 선택적인 제2 표적 DNA 종 그리고 상기 기준 DNA 종의 각각의 상기 결정량은, 상기 시료 내의 상기 DNA 종의 절대적 양으로 표시된다. 그러나, 본 발명의 일 양태가, 하나 이상의(예를 들어 2개) 제1 표적 DNA 종(즉, 염색체 이수성와 관련된 염색체)의 결정량을 기준 DNA 종(즉, 기준 염색체)의 결정량과 비교(또는, 상대적 양이나 비율의 고려)하는 것에 관계되기 때문에, 이러한 비교를 수행할 수는 있지만 절대적 양을 고려할 필요는 없다. 설명에 있어서, '기준염색체 신호(signal-Reference-Chromosome)'/'총 DNA 신호(signal-Total-DNA)'에 대한 '표적염색체 신호(signal-Target-Chromosome)'/'총 DNA 신호'의 비율은, 여기서 수학적으로 '총 DNA 신호' 항을 삭제할 수 있기 때문에, '기준염색체 신호'에 대한 '표적염색체 신호'의 비율과 같다. 따라서, 본 발명은 또한, 단계 (e)에서 시료에 존재하는 총 DNA의 양을 모르거나 고려하지 않고 태아에 존재하는 염색체 이수성의 존재(또는 부존재)의 식별이 수행되는 구현형태를 포함한다. 예를 들어, 단계 (e)에서의 결정은 qPCR로부터 생성된 Ct(또는 Cp) 번호들로부터 직접적으로 이루어질 수 있다. 왜냐하면 이들은 정량화되는 DNA 종의 초기 농도(양)에 역관계(inversely correlate)이기 때문이다.
[143] 본 발명의 특정 구현형태에서, 단계 (c) 및/또는 단계 (d), 그리고 선택적 임의 단계 (c)' 및 선택적 임의 단계 (f)에서 다수의 결정 세트(군)가 행해진다. 각 결정 세트는 상기 시료의 DNA의 상이한 분취량(aliquot)을 사용하여 행해지는데, 예를 들어 상이한 용기에서, 그리고 다수 결정 세트의 각 결정과 유효하게 동시에 행해진다. 이러한 다수 결정 세트에 속하는 각 결정은 동일한 시료(예를 들어, 동일한 임신여성에게서 채취한 시료)에 대한 분석(assay)의 '복제본/복제(replicate)'로 취급할 수 있다. 복제본들은, 상이한 용기(vessel)에서(예를 들어 본 발명의 qPCR 구현형태에서 사용되는 것과 같은 동일한(또는 상이한) 마이크로타이터 플레이트(microtiter plate)의 상이한 웰(well)에서) 복제본들에 대한 분석을 수행하도록 이 방법을 구성함으로써, 이 분석 방법에 효율적으로 결합될 수 있다.
[144] 시료의 복제본을 사용하는 본 발명의 구현형태에서, 상기 시료 복제본의 수(다수 결정 세트)는 2 내지 약 50(세트), 예를 들면 2 내지 약 20, 2 내지 약 10, 또는 약 5 내지 약 15(세트)이다. 바람직하게는 상기 결정의 복제 수(결정의 세트수)는 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 및 12(세트) 중에서 선택되고, 특정적으로는 약 3 내지 10 세트의 결정, 더 특정적으로는 약 6 세트의 결정이다. 예를 들어, 마이크로타이터 플레이트를 사용하는 분석 구현형태에 있어서 결정 복제의 수는, 본 발명 방법이 마이크로타이터 플레이트의 해당 수의 (상이한) 웰에서 동일한 시료의 여러 분취량들에 대해 실시되는 것으로 대변될 수 있다.
[145] 이 방법에 복제본을 포함시키으로써, 그리고 선택적 임의사항으로서 그것들을 분석함으로써, 예를 들어 이 방법의 강인성, 오류, 또는 기타 변동성에 관한 부가적인 정보를 제공할 수 있고, 따라서 이로부터 결정되는 하나 이상의 DNA 양을 제공할 수 있다. 실제로, 상기 복제본을 사용하는 본 발명의 특정 구현형태에서, 단계 (e) 및/또는 선택적 임의 단계 (e)'에서 결정된 상대적 양(들) 또는 비율(들)은, 단계 (c) 및/또는 단계 (d), 그리고/또는 선택적 임의 단계 (c)' 및/또는 선택적 임의 단계 (f)에서 행해지는 다수 세트의 결정 단계에 의해 결정된다. 이러한 구현형태에서는 각 (복제된) 세트에서 결정된 DNA의 평균(average)(예를 들어, 각 (복제된) 세트별로 결정된 DNA 양의 평균값(mean), 중앙값(median), 또는 최빈값(mode); 바람직하게는 각 (복제된) 세트별로 결정된 DNA 평균값)을 이용하여 DNA 양을 정할 수 있다.
[146] 대안으로서 또는 부가적으로, 본 발명 방법은 상이한 임신여성(예를 들어, 인간)으로부터 각각 채취한 다수의 상이한 시료에 대해 (복제본의 유무에 관계없이) 실시할 수 있다. 이러한 구현형태에서, 특히, 분자 태깅 절차(molecular tagging methodology)가 없을 경우에, 이 방법은 상이한 임신여성으로부터 각각 취한 다수의 시료에 대해 수행되는데, 이 때 각 방법은 별도의 용기에서 수행되며, 다수 시료의 각 시료에 대해 유효하게 동시에 수행된다. 당업자라면 이제 이해할 수 있는 바, 이 방법은 예를 들어 마이크로타이터 플레이트의 다른 웰에서 각 시료에 대해 실시될 수 있다.
[147] 상이한 임신여성에게서 채취된 다수의 시료에 대해 본 발명 방법을 실시하는 경우, 본 방법은 2 내지 약 500개(또는 500개 초과)의 시료, 예를 들어, 2 내지 약 200, 2 내지 약 100, 또는 약 5 내지 약 150 개의 시료에 대해서 실시될 수 있다. 여기서 상기 다수 시료의 개수는 약 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 120, 및 140개(또는 150개 초과) 중 선택되는 것이 바람직하며, 특정적으로는, 각각 다른 임신여성에게서 채취된 약 60개이다.
[148] 특히, 본 발명의 개시에 따르면, 이제, 다수의 임신여성(예를 들어, 인간)으로부터 다수 시료를 채취하는 방법의 실시가 당업자에게 가능할 것인데, 예를 들어, Roche의 LightCycler 같은 마이크로타이터 플레이트 기반 qPCR 시스템을 사용할 수 있다. 이들 다수 시료는 동일한 마이크로타이터 플레이트의 상이한 웰에 투입할 수 있고, 또는 상이한 마이크로타이터 플레이트에 투입할 수 있다. 이렇게 다수 시료를 포함시키고 분석하는 것은, 특히, 각 시료별로 다수의 복제본을 조합하게 되면, 염색체 이수성의 존재(또는 부존재)의 확인을 보다 더 확실하고 신뢰성있게 할 수 있다. 예를 들어, 모든 (상이한) 시료들에 대해 결정된 양의 상대적 변동량(예를 들어, 표준 편차) 대비, 주어진 시료의 여러 복제본에 대해 결정된 양의 상대적 변동량은, 염색체 이수성 검사를 위한 단계 (e)(또는 선택적 임의 단계 (e)')에서 추가 정보를 줄 수 있다. 예를 들어, 복제본들 간에 양의 차이가 크되 상대적 변동량이 적은 경우, 다른 시료들로부터 온 양의 차이가 존재한다는 더 강한 확신을 줄 것이다.
[149] 또한, 한 번의 실행(run)(예를 들어, 마이크로타이터 플레이트)에 여러 개의 시료(및/또는 복제본)을 포함시킴으로써 각 실행에 적어도 여러 개의 상이한 시료가 포함되어 하나의 실행을 다른 실행과 비교할 수 있는 이익을 얻을 수 있다. 또한 실행들 사이의 비교는 여러 실행들에 공통적인 대조군 또는 표준 시료의 사용에 의해 도움을 받을 수 있으며, 이로써 실행 간에 또는 실행 동안에 측정값 또는 계산값의 정규화(normalisation)를 행할 수 있게 된다. 그러나 각 실행마다 여러 가지 많은 시료(예를 들어, 약 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 130, 140, 150, 또는 150 초과), 특정적으로, 각 실행에서 약 60가지의 상이한 시료를 사용하므로, 한 번의 실행에서 결정된 양을, 당업자에게 공지되어 있거나 본 명세서의 다른 곳에서 기술된 것과 같은 정규화 방법을 써서 다른 실행과 비교하게 될 것이다.
[150] 본 발명의 특정 구현형태의 한 특징은, 염색체 이수성에 관련된 염색체의 양을 이 염색체에 위치한 2개(또는 그 이상)의 제1 (또는 제2) 표적 DMR을 이용하여 추정하거나 결정한다는 것이다. 이러한 두(또는 그 이상의) DMR 각각으로부터 결정된 양을 사용 및/또는 고려하므로, 태아에 염색체 이수성이 존재(또는 부존재)하는지를 지시하는(indicate) 데의 추가적인 확실성 또는 확신(신뢰성)을 가질 수 있다. 예를 들어, 단 하나의 표적 DMR에 대해서 결정된 양이 염색체 이수성이 존재함을 지시하는 경우, 이는 2개(또는 그 이상)의 표적 DMR에 대해서 결정된 양이 염색체 이수성의 존재를 지시하는 결과보다 확실성 또는 신뢰성이 더 적다고 간주될 수 있는 것이다.
[151] 따라서, 본 발명은, 제1 표적 DNA 종의 양이 제1 표적 DMR 중 하나에서의 메틸화의 검출량으로부터 결정되고, 제1 표적 DNA 종의 양이 제1 표적 DMR 중 다른 것에서의 메틸화의 검출량으로부터 결정되는 구현형태를 포함한다. 이제, 2개(또는 그 이상)의 선택적인 제2 표적 DMR으로부터 결정된 양에 대해 위와 유사한 구현형태를 사용할 수 있음이 명백해질 것이다.
[152] 이러한 구현형태에서 특히, 단계 (e)(및/또는 선택적 임의 단계 (e)')에서 제1 표적 DNA 종의 둘 이상의 양(각각이 상기 하나 이상의 제1 표적 DMR에 대한 양임)별로 둘 이상의 상대적 양(들), 바람직하게는 비율(들)을 결정할 수 있다.
[153] 특정 구현형태에서, 이들 2개 (또는 그 이상의) 양의 조합된 분석, 예를 들어, 2개 이상의 양의 평균값 또는 중앙값을 고려할 수 있다. 또는 이와 달리, 본 명세서에 기재된 바와 같이, 특정 구현형태에서는, 단계 (e)(및/또는 선택적 임의 단계 (e)')에서 결정된 둘 이상의(바람직하게는 각각의) 상대적 양(들) 또는 비율들을 독립적으로 또는 개별적으로 사용하여, 태아에 염색체 이수성이 존재하는지 아닌지를 고려하거나 결정하거나 나타낼 수 있다. 이러한 '2차원적' 고려 또는 분석은, 도 7에 도시된 바와 같은 산포도를 사용하여 그리고/또는 도 8에 나타낸 것과 같이 대량의 상이한 시료 및 복제본을 사용(선택사항으로서, 실행 간의 정규화를 이용)한 후에 표현하거나 시각화할 수 있다. 이제 명백해질 바, 표적 DMR로서 3개 이상의(가령, 제3의) DMR을 이용하면 더욱 더 확실성이나 신뢰성을 얻게 될 것이며, 특히 본 발명은 더 추가적인 표적 DMR을 이용함으로써, 예를 들어 염색체 이수성의 확인을 더욱 보조하기 위한 '3차원적' 분석을 제공할 수 있을 것이다.
[154] 제1(또는 제2) 표적 DMR에서 각각 결정된 표적 염색체의 양은 임계값 또는 양의 기준 분포과 비교할 수 있다. 특히, 본 발명의 특정 구현형태는, 단계 (e)에서 전술한 상대적 양(들) 또는 비율(들) 중 2개 이상(바람직하게는 각각)을 임계값(들) 및/또는 기준 분포(들)과 비교할 수 있다. 여기서 상기 상대적 양(들) 또는 비율(들) 중 둘 이상(바람직하게는 각각)이 상기 임계값 및/또는 기준 분포(들)보다 큰지 낮은지가 태아내 염색체 이수성의 존재, 부존재를 지시한다.
[155] 본 명세서에 기술된 바, 임계값(들) 및/또는 양의 기준 분포(들)은 외부 기록 또는 정보로부터 지정되거나 제공받을 수 있으며, 또는, 본 발명 방법에 따라 분석된 다수의 시료 및/또는 결정된 양을 사용, 고려, 및/또는 분석하여 정할 수 있다. 따라서, 특정 구현형태에서, 임계값 및/또는 기준 분포는 여러 임신여성으로부터 채취된 다수의 시료로부터 정해질 수 있는데, 전술한 바와 같은 방법을 시료에 대해 실시함으로써 정해질 수 있다. 여기서 선택적 임의사항으로서 (다수 세트의) 결정의 복제는, 예를 들어 명세서에서 제시된 방법을 각 시료에 대해 실시함으로써, 단계 (c) 및/또는 단계 (d), 그리고 선택적 임의 단계 (c)' 및 단계 (f)에 대해서 행해진다.
[156] 본 발명 방법에서 다수의 시료 및/또는 복제본을 분석할 때, 시료들(및/또는 복제본들)은 상이한 그룹 또는 실행(run)(예를 들어, qPCR 실험에서 사용되는 상이한 마이크로타이터 플레이트)에 배치할 수 있다. 이러한 구현형태에서, 상기 다수의 시료/복제본들의 2개 이상의 그룹을 그룹별로(group-by-group) 분석할 수 있는데, 예컨대, 각 그룹을 별도의 실행, 분석, 또는 마이크로타이터 플레이트에서 분석한다. 그리고 각 그룹의 시료에서 결정된 양(들) 또는 비율(들)을 정규화하여 임계값 및/또는 기준 분포를 정한다. '정규화'(normalisation)는 한 그룹의 시료/복제본으로부터 결정된 결과(예를 들어, 양)를 다른 그룹의 결과와 비교하거나 비교가능하게 할 수 있는 임의의 적절한 방법으로 간주할 수 있다. 예를 들어, 하나의 실행(또는 마이크로타이터 플레이트)에서 수행된 분석결과를 다른 실행(또는 마이크로타이터 플레이트)의 분석결과와 비교할 수 있도록 하는 방법이다. 당업자는 다양한 정규화 접근법을 이용할 수 있는데, 여기서 시료 그룹들 간의 상기 정규화는 시료에 특정된(sample-specific) 양 또는 비율(예를 들어, 시료에 대해 여러 세트 행해진 결정의 평균값) 및 상기 특정 시료가 속한 동일 그룹 내의 모든 시료에 대해 결정된 양 또는 비율의 평균(예를 들어, 중앙값) 간의 차이를 고려함으로써 수행될 수 있다. 이에 대해서는 특히 실시예 4에 기술되어 있고 도 8에 도시되어 있다.
[157] 이러한 시료 특이적 양을 감안하면, 태아 내의 염색체 이수성의 존재는, 임계값(들) 및/또는 기준 분포(들)와 비교된 하나 이상의 제1 표적 DMR(바람직하게는 2개 또는 각각)에 대해 결정된 양(들) 또는 비율(들)의 이탈값(outlier)인 해당 태아에 대한 시료 특이적 양 또는 비율에 의해 지시(indicate)될 수 있다. 이러한 구현형태에서 특히, 태아에서의 염색체 이수성의 존재는 아래 (a) 및/또는 (b)에 제시된 위치에 모여있는 수치집단(numerical cluster) 내에 위치하는 해당 태아에 대한 시료 특이적 양 또는 비율에 의해 지시될 수 있다. 즉, (a) 정배수체(euploid)인(또는 추정되는) 다수의 다른 태아에 대한 시료 특이적 양 또는 비율이 모여 있는 수치집단의 외부, 및/또는 (b) 염색체 이수성을 갖는 태아들을 나타내는 다수의 다른 시료들에 대한 시료 특이적 양 또는 비율이 모인 수치집단의 내부 ― 여기서 바람직하게는, 상기 태아들을 나타내는 상기 다수의 다른 시료들은 약 2~10, 12~15, 16~25, 26~30, 32~40, 42~50, 52~75, 78~100 , 105-125, 130-150, 155-175, 180-200, 205-250, 255-300, 305-350, 355-400, 405-450, 455-500개, 및 500개 초과일 수 있다. 관련된 구현형태에서, 이 수치집단은 결정량의 산포도에 원형 또는 난형으로 모여있을 수 있는데, 이 원형 또는 난형 집단의 좌표는 본 방법에서 분석된 시료로부터 사전정의되거나 계산될 수 있다. 따라서 둘 이상의 표적 DMR에서 기준 염색체와 비교하여 결정된 표적 염색체의 양(들)을 이러한 좌표에 대해서, 경계 안에 존재하는 양들을 갖는 시료는 이 시료가 채취된 임신여성이 수태한 태아에 염색체 이수성이 존재한다는 것을 지시한다는 것을 고려할 수 있다. 다양한 정도의 확실성 또는 신뢰도를 갖는 이수성 시료를 정하기 위해 여러 상이한 경계를 설정할 수 있음은 명백할 것이다. 예를 들어, 경계에 가깝게 있는 것들, 또는 경계의 외부에 있지만 제2의 경계 내(소위 '회색 지대')에 있는 것들은 추가 분석 또는 검사의 대상이 될 수 있다. 실제로, 본 발명 방법은 선행 기술의 NIPT 분석법(예를 들어, 차세대 시퀀싱 기반 NIPT 이수성 검사)에서 검사되어야 할 시료의 수를 현저하게 감소시키는 수단으로서 종래의 NIPT 분석 전에 걸러내는(사전차단) 용도로 실시할 수 있다. 예를 들어, 경계의 구획(definition)(예를 들어, '회색 지대'의 시작이 되는 지점)을 이용하여 다수의 음성(negative) 시료를 찾아낼 수 있고(즉, 임신부가 정배수체 태아를 수태하고 있음을 알 수 있음), 따라서 음성이 아닌 것이 확실한 훨씬 더 적은 수의 시료만 종래의 MIPT 분석을 사용하여 검사하면 된다. 수 퍼센트의 거짓양성율을 갖는 이러한 사전차단 작용을 하는 진단 분석법을 사용하여서도, 특히 이러한 분석법의 거짓음성율이 낮은 경우에는 매우 효율적인 사전차단 효과를 얻을 수 있다.
[158] 다른 구현형태에서, 상기 수치집단/원형/난형 분석과 z스코어 분석을 조합할 수 있다. 예를 들어, 수치집단/원형/난형 분석은 정배수체 시료를 식별하기 위해 수행될 수 있고, z스코어 분석(예를 들어, 명세서에 기술된 것)은 이수성 시료를 식별하기 위해 수행될 수 있다. 따라서 이와 같은 상이한 분석 기법의 일치도를 보여주는 시료의 경우에 염색체 이수성의 식별에 대한 확실성은 더 커질 것이다.
[159] 이러한 분석에 앞서 또는 그 일부로서, 하나 이상의 시료, 측정치, 신호, 및/또는 본 방법에서 결정된 양은 하나 이상의 품질 관리 절차 또는 단계의 적용을 받는다. 예를 들어, 시료에 존재하고/존재하거나 시료로부터 추출된 DNA의 농도 및/또는 단편화(fragmentation)의 패턴을 단계 (b) 이전에 고려할 수 있고, 시료를 분석에 포함시키지 않거나 또는 (고농도의 경우에는) DNA를 희석시킬 수 있다.
[160] 특히, 본 발명의 이러한 구현형태에서, 단계 (b) 전에, DNA의 농도는 예를 들어, 단편 분석기(Advances Analytical Technologies 사의 Ankeny, 미국)를 사용하여 예를 들어 DNF-474 고감도 NGS 키트(Advances Analytical Technologies 사의 Ankeny, 미국)로 측정할 수 있다. 80~220bp의 크기에 위치할 수 있으며 평균적으로 165bp에 위치하는 첫 번째 현저한 DNA 농도 피크(peak)를 판정할 수 있는데, 이 피크는 분리된 무세포 DNA를 나타내는 것일 수 있다. 특정 구현형태에서, 이 DNA 농도 피크가 약 0.3 ng/uL보다 높은 것으로 보이는 시료는 약 0.3 ng/uL로 희석한다. 이러한 희석은 저농도 시료와 비교하여 너무 높은 DNA 농도로 인한 시료의 거짓양성 예측을 피할 수 있게 해준다. 이러한 단편 분석을 적용할 수 있는 또 다른 QC(품질관리) 기준에는, (예를 들어, 약 100bp 미만의 크기에서 일어나는 톱니 모양의 피크로 표현되는) 무세포 DNA가 단편화되고/또는 게놈 DNA에 의해 오염된 시료를 검출(예를 들어, 배제)하는 것이 포함된다.
[161] 본 발명의 모든 양태에 포함시킬 수 있는 그 밖의 품질관리 기준에는, 다음의 것들 중 하나 이상이 사실인 경우에만 시료에서 취득한 데이터를 분석에 포함시키는 것이 포함된다.
- 데이터 생성시 복제본의 수가 약 4, 5, 6, 7, 또는 8보다 많다, 그리고/또는
- 이용된 하나 이상의 DMR 또는 옵션으로 이용된 OR에 대한 qPCR 채널에서의 평균값 Cp가 약 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36 미만이다, 그리고/또는
- 이용된 하나 이상의 DMR 또는 옵션으로 이용된 OR에 대한 qPCR 채널에서의 Cp 평균값의 표준편차가 약 0.5, 0.6, 0.7, 0.8, 0.9, 또는 1.0 미만이거나 약 1.1, 1.2, 1.3, 1.4, 또는 1.5 미만이다, 그리고/또는
- 모든 복제본은 이용된 DMR 및 옵션으로 이용된 OR에 대한 모든 qPCR 채널에서 유효한 값을 갖는다, 그리고/또는
- 단편 분석에서, 시료는 약 100bp 아래에서 톱니 모양의 피크를 보이지 않고 및/또는 게놈 DNA로부터의 오염을 보이지 않는다, 그리고/또는
- cfDNA의 농도는 약 0.05, 0.1, 0.15, 0.2 ng/uL보다 크고 및/또는 약 0.3, 0.4, 또는 0.5ng/uL보다 작다, 그리고/또는
- 총 DNA를 측정하는 qPCR 채널에서의 평균값 Cp는 약 22, 24, 25, 26, 27, 또는 28보다 크다.
[162] 시료에 존재하는 총 DNA(및 그에 따라 예를 들어, cfDNA의 태아분(fraction))이 결정되며 또 태아 내의 염색체 이수성의 식별이 이루어지는 본 발명의 구현형태에서, 본 발명 방법은 임신여성이 임신관련 의학적 증상으로 고통 받거나 또는 발병의 위험의 증가를 감지하는 데 적용될 수 있다.
[163] 따라서, 본 발명의 다른 양태는 임신여성이 임신관련 의학적 증상을 앓고 있을 위험 또는 발병의 위험 증가를 감지하는 방법에 관한 것이다. 이 방법은,
(i) 전술한 본 발명 방법을 수행하는 단계;
(ii) 시료에 존재하는 태아 DNA의 적어도 하나의 양(예를 들어, 절대적 양 또는 상대적 양)을 결정하는 단계, 그리고
(ⅲ) 결정된 태아 DNA의 양을 임계값 및/또는 기준 분포와 비교하는 단계, 여기서 상기 임계값 및/또는 기준 분포로부터 상기 태아 DNA의 양이 증가 또는 이탈(outlying)을 보이는 것은 임신여성이 상기 임신관련 의학적 증상을 앓고 있는 또는 발병할 위험이 증가하는 것을 지시한다.
[164] 상기 위험은 다음의 경우들을 고려하여 대체적으로 또는 추가적으로 평가할 수 있다. 즉, (i) 태아 cfDNA(해당 여성에 대하여 임계값과 비교하여 결정된 양)의 배수 증가(예를 들어, 1.5, 3, 3.5배, 또는 4배 증가)를 고려하되, 후기 임신의 경우에 태아 cfDNA의 배수 증가가 더 크다는 것을 결정 요소로 넣을 수 잇다(Zeybek 외, 2013, J Obstet Gynaecol Res 39:632), 그리고/또는 (ii) 저 위험 여성 또는 자간전증을 겪지 않았거나 발병하지 않은 여성에게서 결정할 수 있는 양의 기준 분포를 고려할 때 여성에서 결정된 것같은 cfDNA의 양의 백분위수(percentile)가 감소하는지를 고려하여서 평가할 수 있다. 예를 들어, 만일 태아분의 cfDNA가 이 양의 기준 분포의 90번째 백분위수(90th percentile) 이내에 있다면 이 여성은 경증 또는 중증의 자간전증을 앓고 있을 위험이 증가한 것으로 간주될 수 있다(Jakobsen 외, 2013, Transfusion 53:1956). 적정 임계값을 정할 때에는 그 외의 관련 인자를 고려할 수 있다. 예를 들어, 유방암을 앓는 임신여성의 경우, 혈장 내에 존재하는 RASSF1A에서의 메틸화의 편향이 두 가지 요인 모두로 인해 더 높을 수 있다.
[165] 이와 유사하게, 본 발명의 이러한 양태의 특정 구현형태는, 검출된 상기 DNA 종의 양을 양의 임계값 및/또는 기준 분포과 비교하는 단계를 추가로 포함한다. 여기서 상기 DNA 종의 양이 상기 임계값보다 많은 경우(또는 상기 모집단과 비교하여 이탈값이 아닌 경우)는 상기 시료에 존재하는 상기 DNA 종의 이상(abnormality)에 대한 진단을 (바람직하게는 상기 DNA의 별도의 분취량에 대해) 수행할 수 있음을 나타낸다, 예를 들어, 태아분의 cfDNA가 모체 혈장에 존재하는 총 cfDNA의 약 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1%, 또는 0.5%를 초과(특정적으로는 약 4% 초과, 보다 특정적으로는 약 3% 초과의 태아분 cfDNA)한다면, 태아 cfDNA의 하나 이상의 특성을 조사하기 위해 후속 검사, 예를 들어, 이러한 태아 cfDNA 내에 포함된 돌연변이 염색체 변이의 가능성 또는 존재의 검사(대용량 병렬 시퀀싱에 기초한 NIPT 사용)를 유효하게 수행하기에 충분한 태아분 또는 태아 cfDNA가 있는 것일 것이다. 쌍태 임신의 경우, 본 발명자들은 쌍태 임신의 NIPT를 위한 최소 cfDNA 태아분은 8%, 또는 약 5%, 6%, 7%, 9% 또는 10%로 간주할 수 있다고 결정하였다. 그리고 일치 유전자형(concordant genotype)을 가진 단발성 쌍태 임신의 경우에는(희귀한 예외를 제외하고, Chen 외, 2013, Am J Med Genet A, 161A:1817 참조), cfDNA 태아분은 4%, 또는 약 2%, 3% 또는 5%면 충분할 것이다.
[166] 본 발명의 추가적 양태는 특정 조성물(예를 들어, 본 발명 방법에 유용하거나, 본 발명 방법의 일부로서 사용되거나 생성되는 조성물)에 관한 것이다. 조성물은 다양한 성분의 혼합물 또는 다른 조합일 수 있다. 따라서, 본 발명은 또한 둘(또는 그 이상의) 표지처리된 프로브(예를 들어 qPCR을 위한 핵산 프로브)를 포함하는 조성물을 제공한다. 여기서 각 프로브는 상기 둘 이상의 제1 표적 DMR 중 하나를 검출하기 위한 것이다(예를 들어, 서열번호 51에 위치한 DMR을 검출하기 위한 하나의 프로브, 및 서열번호 185에 위치한 DMR을 검출하기 위한 다른 프로브). 특히 이러한 구현형태에서, 조성물에 존재하는 둘 이상의 상기 프로브는 상이한 검출 표지(들)로 표지처리된다. 프로브(및 표지)는 본 명세서에 개시된 제1 표적 DMR들 중 하나를 위한 것일 수 있다. 특히, 표 1 및/또는 표 5 및/또는 표 E 및/또는 표 8 및/또는 표 10에 나타낸 것일 수 있다. 조성물은 2개, 3개, 4개, 5개, 또는 5개 초과의 제1 표적 DMR을 검출하기 위한 프로브를 포함할 수 있고, 본 명세서의 다른 곳에서 설명된 바와 같은 검출 표지(들)로 표지처리될 수 있다.
[167] 이러한 양태의 특정 구현형태에서, 조성물은 하기 추가 성분 중 하나 이상을 추가로 포함할 수 있다.
- 두 쌍 이상의 PCR 프라이머. 각 쌍은 상기 2개 이상의 제1 표적 DMR 중 하나를 증폭하기 위한 것으로, 예를 들어 조성물 내의 프로브 검출을 위한 제1 표적 DMR을 증폭하기 위한 것이다(예를 들어, 서열번호 51에 위치하는 DMR을 증폭시키는 하나의 프라이머쌍, 그리고 서열번호 185에 위치하는 DMR을 증폭하기 위한 다른 프라이머쌍), 그리고/또는
- 둘 이상의 표지처리된 프로브(예를 들어, qPCR을 위한 핵산 프로브). 각 프로브는 상기 둘 이상의 기준 DMR 중 하나를 검출하기 위한 것이다(예를 들어, 서열번호 66에 위치한 DMR을 검출하기 위한 하나의 프로브, 그리고 서열번호 102에 위치하는 DMR을 검출하기 위한 다른 프로브). 특히 상기 구현형태에서, 조성물에 존재하는 두 개 이상의 또는 상기와 같은 프로브는 동일한 검출 표지(들)로 표지처리된다. 프로브(및 표지)는 본 명세서에 개시된, 특히 표 1 및/또는 표 5 및/또는 표 E에 개시된 기준 DMR들 중 하나에 대한 것일 수 있다, 그리고/또는
- 두 쌍 이상의 PCR 프라이머. 각 쌍은 상기 둘 이상의 기준 DMR 중 하나를 증폭하기 위한 것으로, 예를 들어, 조성물 내의 프로브 검출을 위한 기준 DMR을 증폭하기 위한 것이다(예를 들어, 서열번호 66에 위치하는 DMR을 증폭시키는 하나의 프라이머쌍, 그리고 서열번호 102에 위치하는 DMR을 증폭하기 위한 다른 프라이머쌍).
[168] 이러한 양태의 대안적 또는 추가적 구현형태에서, 조성물은 하기의 추가 성분 중 하나 이상을 더 포함할 수 있다.
- 적어도 한 쌍의 추가 프라이머(바람직하게는 두 쌍의 추가 프라이머쌍). 각 쌍은 상기 적어도 하나의 OR들 중 하나를 증폭하기 윗한 것이다, 그리고/또는
- 적어도 하나의 추가 표지처리 프로브(바람직하게는 2개의 추가 표지처리 프로브). 각 프로브가 전술한 OR의 적어도 하나를 검출한다. 특히 이러한 구현형태에서, 조성물에 존재하는 두 개 이상의 또는 이와 같은 프로브는 동일한 검출 표지(들)로 표지처리된다. 프로브(및 표지)는 본 명세서에 개시된, 특히 표 1 및/또는 표 D 및/또는 표 5 및/또는 표 E에 개시된 OR들 중 하나를 위한 것일 수 있다.
[169] 이러한 양태의 또다른 대안적인 또는 추가적인 구현형태에서, 조성물은, 특히 제1 표적 DMR보다 제2 표적 DMR이 염색체 이수성과 관련된 다른 염색체에 위치하는 경우에, 하나의, 둘의, 또는 셋 이상의 제2 표적 DMR을 증폭 및/또는 검출하기 위한 하나 이상의 추가 성분을 더 포함할 수 있다.
[170] 본 발명의 또다른 추가적인 양태는 키트이다(예를 들어, 분리된 성분들의 키트 ― 여러 성분을 보유하고 있는 홀더나 용기인 키트). 이러한 키트는 프라이머 및/또는 프로브의 조합을 포함하는데, 이 조합은 본 발명의 조성물에 관련하여 기술된 바와 같다. 예를 들어, 본 발명의 키트는 두 개의(또는 그 이상의) 표지처리된 프로브(예를 들어, qPCR용의 핵산 프로브)를 포함할 수 있다(묶음으로 또는 별도로 또는 혼합하여). 여기서 각 프로브는 상기 둘 이상의 제1 표적 DMR 중 하나를 검출하기 위한 것이다(예를 들어, 서열번호 51에 위치한 DMR을 검출하기 위한 하나의 프로브, 및 서열번호 185에 위치한 DMR을 검출하기 위한 또 다른 프로브). 예를 들어, 키트에 존재하는 2개 이상의 프로브는 상이한 검출 표지(들)로 표지처리된다. 추가적인 프로브 및/또는 프라이머(본 발명의 조성물의 맥락에서 기술된 것과 같은)가 선택사항(옵션)으로 본 발명의 키트에 포함될 수 있다(예를 들어, 서열번호 51에 위치하는 DMR을 증폭하기 위한 하나의 프라이머쌍 및 서열번호 185에 위치한 DMR을 증폭하기 위한 또 다른 프라이머쌍, 및/또는 서열번호 66에 위치한 DMR을 검출하기 위한 하나의 프로브 및 서열번호 102에 위치한 DMR을 검출하기 위한 또 다른 플포브, 및/또는 서열번호 66에 위치한 DMR을 증폭하기 위한 하나의 프라이머쌍 및 서열번호 102에 위치한 DMR을 증폭하기 위한 또 다른 프라이머쌍).
[171] 특정 구현형태에서, 키트 또는 조성물에 존재하는 프로브 및/또는 프라이머의 서열은, 서열 특이적 방식으로, 바이설페이트 변환된 DNA를 검출하도록 변형될 수 있다. 예를 들어 이러한 서열 변형된 프라이머 또는 프로브는 본 발명 방법의 MSP 또는 메틸라이트(MethylLight) 구현형태를 위해 사용되거나 이에 유용할 수 있다.
[172] 본 발명의 키트는 임신여성에 수태된 태아의 염색체 이수성의 검출 및/또는 임신여성이 의학적 증상을 앓고 있는 또는 발병할 위험이 증가하는 것을 감지하는 데 사용될 수 있거나 이에 유용할 수 있다.
[173] 또다른 구현형태에서, 본 발명의 키트는 추가 성분을 포함할 수 있다. 예를 들어, 키트는 추가로, (i) 본 발명 방법을 실시하기 위한 그리고/또는 본 발명 조성물을 제조 또는 사용하기 위한 상기 프라이머 및/또는 프로브의 사용 지침이 담긴 인쇄 매뉴얼 또는 컴퓨터 판독가능 메모리, 및/또는 (ii) 본 발명 방법의 실시 및/또는 본 발명 조성물의 제조 또는 사용에 유용한 하나 이상의 다른 품목, 구성품, 또는 시약, 그리고 이러한 실시 또는 제조에 유용한 본 명세서에 기재된 모든 품목, 구성품, 또는 시약을 더 포함한다. 예를 들어, 상기 키트는 상술한 메틸화 및 비메틸화 DNA를 상이하게 변형시키는 시약, Taq 폴리머라제, 및/또는 반응 완충액 등을 추가로 포함할 수 있다.
[174] 다른 비한정적 예시로, 본 발명의 키트는 하기 구성품 중 하나 이상을 추가로 포함할 수 있다.
- 상기 임신여성으로부터 채취된 혈액 등의 조직 시료를 수집 및/또는 저장하는 수단. 바람직하게 이 수단은 채혈 튜브임. 및/또는
- 상기 임신여성으로부터 채취된 시료로부터 DNA(바람직하게는 무세포 DNA)를 추출하는 수단. 바람직하게 이 수단은 무세포 DNA 추출 키트임, 및/또는
- 본 발명 방법의 맥락에서 기술된 상기 수단들 중 하나 또는 모두를 식별, 취득, 및/또는 사용하기 위한 지침이 포함된 인쇄된 매뉴얼 또는 컴퓨터 판독가능 메모리, 및/또는
- 본 발명의 컴퓨터 프로그램 제품, 또는 이러한 컴퓨터 프로그램 제품에 액세스하거나 그 결과를 생성하는 방법에 관한 지침.
[175] 조성물 또는 키트의 특정 구현형태에서, 여기에 포함되는 프라이머 또는 프로브 중 하나 이상은 표 1, 표 D 및/또는 표 5 및/또는 표 E 및/또는 표 8 및/또는 표 10에 기재된 것 중에서 선택된 프라이머 또는 프로브 서열을 포함한다(또는 이 서열로 구성된다). (선택사항으로서, 상기 표에 프로브에 대해서 제시된 검출 표지(들)이 사용된다.) 이러한 특정 구현형태에서, 조성물 또는 키트는 표 5에 기재된 바와 같은(또는 표 E에 제시된 각 분석 버전 V10.1, V10.2, V10.3, V10.4, V10.5, 및 V10.6, 특히, 분석 버전 V10.3과 관련된) 프라이머쌍 및 프로브를 포함하는데, 이 프라이머쌍 및 프로브는 (x) 두 제1 표적 DMR의 각각, (y) 두 기준 DMR의 각각에 사용되며, 그리고 선택적(옵션)으로, (z) 하나 또는 두 개의 OR과 함께 사용된다. 특히, 제1 표적 DMR을 위한 프로브는 상이하게 표지처리되고, 2개의 기준 DMR을 위한 프로브는 동일한 검출 표지(들)로 표지처리되고, 2개의 OR을 이용한다면 이들을 위한 프로브는 동일한 검출 표지(들)로 표지처리된다.
[176] 특정 구현형태에서, 프로브는 이러한 프로브에 대해 표에 기재된 바와 같이 표지/소거제(및 선택적으로 minor groove binding moiety)로 표지처리될 수 있다.
[177] 다른 양태에서, 본 발명은 명세서에서 정의된 프라이머 또는 프로브 중 하나의 서열, 또는 증폭된 DMR의 서열로 구성되는(또는 이를 포함하는) 핵산(nucleic acid)을 제공하는데, 이 핵산은 합성된(synthetic), 분리된(isolated), 및/또는 정제된(purified) 핵산인 것이 바람직하다. 특정 구현형태에서, 프라이머는 검출 표지에 공유 결합된다. 특정 구현형태에서, 이러한 프로브 및/또는 프라이머의 서열은 서열 특이적 방식으로 바이설페이트 변환된 DNA(bisulphite converted DNA)를 검출하기 위해 변형(modify)시킬 수 있다. 예를 들어 이러한 서열 변형된 프라이머 또는 프로브는 본 발명 방법의 MSP 또는 메틸라이트 구현형태에 유용할 수 있다.
[178] 다른 양태로, 본 발명의 키트는 하나 이상의 상기 핵산과 함께 다음의 것들을 포함할 수 있다. 즉, (i) 상기 핵산을 본 방법에 관련하여 식별, 취득, 및/또는 사용하기 위한 지침이 포함된 인쇄 매뉴얼 또는 컴퓨터 판독가능 메모리, 및/또는 (ii) 본 발명의 컴퓨터 프로그램 제품, 또는 이러한 컴퓨터 프로그램 제품에 액세스하거나 그 결과를 생성하는 방법에 관한 지침. 이러한 키트는 본 명세서에 기재된 모든 품목, 구성품, 또는 시약을 포함하여, 본 발명 방법의 실시에 유용한 그리고/또는 이러한 실시 또는 제조에 유용한 하나 이상의 다른 품목, 구성품, 또는 시약 등의 추가 구성품을 더 포함할 수 있다.
[179] 본 발명의 또 다른 양태는, 임신여성에 의해 임신되는 태아의 염색체 이수성을 검출하기 위해 이 임신여성에게서 채취한 시료에 대한 검출 연산(operation)을 수행 및/또는 관리하도록 컴퓨팅 시스템을 제어하기 위한 다수의 명령어로 인코딩된 컴퓨터 판독가능 매체를 포함하는 컴퓨터 프로그램 제품에 관한 것이다. 상기 시료는 모체에서 유래한 상이하게 메틸화된 DNA와 혼합된 태아 및/또는 태아 태반에서 유래한 DNA를 포함하고 있고, 상기 시료에 존재하는 DNA를 본 발명 방법에서 일어나는 메틸화된 DNA 및 메틸화되지 않은 DNA를 상이하게 변형시키는 시약으로 처리한다. 상기 검출 연산은 아래의 단계를 포함한다.
- (i) 본 발명의 방법의 단계 (c)에서 설명한 바와 같이 상기 시료에 존재하는, 염색체 이수성에 관련된 염색체인 제1 표적 DNA종의 양을 각각 나타내는 2개(또는 그 이상)의 신호, 및 (ii) 본 발명의 방법의 단계 (d)에서 설명한 바와 같이, 상기 시료에 존재하는, 하나 이상의 기준 염색체인 기준 DNA 종의 양을 나타내는 하나의 신호를 수신하는 단계;
- (ii)에서 수신된 신호가 나타내는 기준 염색체의 양 대비 (i)에서 수신된 적어도 하나의 신호(바람직하게는 두 신호)가 나타내는 염색체 이수성에 관련된 염색체의 적어도 하나의(바람직하게는 둘) 상대적 양(들)에 기초하여, 상기 임신여성이 수태한 태아에 염색체 이수성이 존재할 가능성이 있는지의 유형(classification)을 정하는 단계. 여기서 적어도 하나(바람직하게는 적어도 둘)는 태아 내의 염색체 이수성의 존재 또는 부존재를 지시한다.
[180] 본 발명의 컴퓨터 프로그램 제품의 특정 구현형태에서, 상대적 양은 위 (i)에서 수신된 2개(또는 그 이상)의 신호로부터 계산되거나 생성될 수 있다. 예를 들어, 평균값, 중앙값, 및/또는 z스코어가 계산 또는 생성된다.
[181] 컴퓨터 프로그램 제품의 다른 특정 구현형태에서, 단계 (c) 및 단계 (d)에서 결정된 상기 DNA의 양을 나타내는 신호들은, 상기 시료의 동일 분취량을 사용하여, 그리고 동일한 용기에서 만들어질 수 있고, 또 상기 제1 표적 DMR들 및 상기 기준 DMR들에 대해 유효하게 동시에 만들어질 수 있다. 그리고 선택사항으로, (x) 상기 기준 DMR의 적어도 2개(바람직하게는 각각)에 대해 동일한 검출 표지(들)를 사용하여서, 그리고 (y) 상기 제1 표적 DMR의 적어도 둘(바람직하게는 각각)에 대해 상이한 검출 표지(들)를 사용하여서 만들어질 수 있다.
[182] 컴퓨터 프로그램 제품에 의해 제어되는 상기 연산은 임계값(들) 및/또는 기준 분포(들)와 비교함으로써 상기 유형을 정할 수 있는데, 여기서 상기 상대적 양(들) 또는 비율(들) 중 하나 이상(바람직하게는 2 이상)이 상기 임계값(들) 및/또는 기준 분포(들)보다 높거나 낮은 것은 태아에 염색체 이수성이 존재하는지를 지시한다. 특히, 상기 연산은, 상이한 임신여성로부터 각각 채취한 다수의 시료에 관련된 상기 (ⅰ) 및 (ⅱ)의 다수의 신호를 수신함으로써 상기 다수의 시료로부터 상기 임계값(들) 및/또는 기준 분포(들)을 계산하는데, 여기서 선택사항으로 상기 다수의 시료는 본 발명 방법에 의해 하나 이상의 시료 그룹에서 분석된다. 그리고 상기 방법은 별도의 용기에서 특정 그룹에 속하는 각 시료에 대해 수행되며, 해당 그룹 내 다수 시료들의 다른 구성 시료와 유효하게 동시에 수행된다.
[183] 컴퓨터 프로그램 제품의 특정 구현형태들에서, 상기 연산은 이하 단계들을 하나 이상 추가로 포함한다.
- 현재의 상기 태아 DNA의 양을 상기 임계값 및/또는 기준 분포와 비교하여 임신여성이 임신관련 의학적 증상을 앓고 있는 또는 발병할 위험이 증가하는지의 유형을 정하는 단계. 여기서 상기 임계값 및/또는 기준 분포로부터 상기 태아 DNA의 양이 증가하거나 이탈값을 보이는 것은 임신여성이 상기 임신관련 의학적 증상을 앓고 있는 또는 발병할 위험이 증가한 것을 지시한다. 그리고/또는
- 예를 들어 본 명세서에 개시된 것과 같은 품질관리 계산, 품질관리 프로세스, 또는 품질관리 단계.
[184] 본 발명의 특정 구현형태에서, 품질관리 계산, 품질관리 프로세스, 또는 품질관리 단계는 모든 결정 단계 전에 수행되도록 할 수 있다. 이렇게 할 경우에, 요구되는 QC(품질관리) 기준을 통과하지 못하는 시료/분석은 더 이상의 단계, 프로세스, 또는 분석에 포함시키지 않는다.
[185] 특정 문제 또는 환경에 본 발명의 교시를 적용하고 본 발명의 변형예 또는 추가 특징(예를 들어, 추가 양태 및 구현형태들)을 특정 문제 또는 환경에 포함시키는 것은 본 명세서에 포함된 교시에 비추어 당해 분야의 통상의 기술을 가진 자(당업자)의 능력에 속할 것이다.
[186] 문맥상 달리 의미하지 않는 한, 전술한 특징들에 대한 설명 및 정의는 본 발명의 특정 양태 또는 구현형태에 한정되지 않으며 설명된 모든 양태 및 구현형태에 동등하게 적용된다.
[187] 본원에 인용된 모든 참고문헌, 특허, 및 출판물은 그 전체적으로 본원의 인용문헌으로서 여기에 포함된다.
[188] 이제, 이상에서 제시한 내용, 도면, 표를 참조하여 본 발명의 특정 양태(aspect) 및 구현형태(embodiment)의 실시예(example)를 설명하기로 한다. 본 발명의 방법, 용도, 및 기타 다른 측면에 대하여 이하의 실시예들은 대표적인 것일 뿐, 본 발명의 범위를 이 대표 실시예로 한정하여서는 아니 된다.
[189] 실시예 1(비교예): 쌍태아소멸의 경우를 포함한 다태 임신에서의 MGS 기반 NIPT 수행 전의 정량화 단계에서 상이한 메틸화 기반 DNA 검출법을 사용함.
[190] 시료 채취, 가공, 및 DNA 추출:
[191] 연구 개발(R&D) 목적 및 일상적인 비침습성 출산전 검사(NIPT) 연구실 절차의 일환으로 2012년 11월 6일부터 2013년 11월 16일까지의 다태 임신(단융모막, 2융모막, 3융모막 쌍태아(mono-, di-, trichorionic twin), 및 세쌍둥이 임신)을 한 임신여성에서 36개의 혈액 시료를 수집했다. 혈액 시료 한 개는 세쌍둥이 임신여성에게서 채취하였고 나머지 35개 시료는 쌍둥이 임신부에서 채취했다. 다태 임신을 한 임신여성 각인으로부커 각각 7~10ml의 정맥혈 시료 2개를 Streck 무세포 DNA 채혈 튜브(Streck)를 사용하여 채집했다. 혈액 시료는 진단 실험실로 최장 이송 기간 4일로 이송하였다. 본원에서 분석된 임신여성으로부터의 다른 혈액 시료도 이와 유사하게 채집되었다.
[192] 원심 분리(4℃에서 10분 동안 1600g)에 의해 혈장을 준비하였고 두 번째 원심 분리 단계(4℃에서 10 분 동안 16000g)에 의해 혈장을 분리하였다. 최종 용리부피(elution volume) 60ul의 AVE-완충액(Qiagen)과 함께 3.0~4.0 ml의 혈장을 사용하는 제조자 프로토콜에 따라 QIAamp Circulating Nucleic Acid Kit(Qiagen)를 사용하여 전체 무세포 DNA(cfDNA)를 추출하였다.
[193] DNA 정량화:
[194] 상이한 메틸화 기반 DNA 검출법을 사용하여 태아분 cfDNA를 상대 농도와 절대적 양으로 결정하기 위해 태아 무세포 DNA(태아 cfDNA)를 전체 무세포 DNA(총 cfDNA)에 대해서 검출하고 정량화하였다. 용리된(eluted) 무세포 DNA로부터, CutSmartTM Buffer(New England Biolabs)를 사용하여 22ul 반응에서 CpG 메틸화 감응성 효소 HhaI(0.4U/ul), HpaII(0.3U/ul), 및 BstUI(0.3U/ul)를 써서 11ul를 분해하였다(digest). 반응물을 37℃에서 60분간, 60℃에서 60 분간 배양(incubate)하였다. Digest 반응으로부터의 10ul를 정량적 프로브 기반 PCR을 위한 템플릿 DNA로 사용하였다(반응은 중복해서 수행하였음). 이에 대해서는 이하에서 간략히 설명한다.
[195] 2배 농축된 PCR 마스터믹스(QuantiFast Multiplex PCR Kit, Qiagen)를 사용하여 25ul PCR 반응을 수행하였다. 태아 및 모체 DNA 간에 상이하게 메틸화된 각 영역(DMR)의 CpG 메틸화 감수성 제한효소 부위에 걸쳐있는(span) 프라이머를 상기 DMR을 위한 FAM 표지처리된 프로브와 조합하여 사용하였고, 어떠한 제한효소 부위 ― 태아와 모체 DNA 간에 상이하게 메틸화되지 않은 타영역(OR) ― 에도 걸쳐있지 않은 프라이머는 이들 OR에 대한 VIC 표지처리된 프로브와 조합하여 사용하였다. 이 실시예에서 사용된 프라이머 및 표지처리된 프로브의 서열은 표 1에 기재되어 있으며, 정량적 프로브 기반(TaqMan) PCR(LightCycler 480II Instrument; Roche)에 사용된 열순환기의 제원은 표 2에 기재되어 있다. 이 실시예에서, 두 DMR의 존재를 검출하는 데 사용한 프로브들은 각각, 동일한 검출가능 FAM(fluorescein amidite) 형광 모이어티(moiety)로 표지처리하고, 또 각각, 동일한 MGB(minor binding grover) 비형광 소거제(NFQ) 모이어티로 표지처리하였고, 두 OR의 존재를 검출하는 데 사용한 프로브들은 각각, 동일한 검출가능 VIC(Life Technologies) 형광 모이어티로 표지처리하고, 또 각각, 동일한 MGBNFQ 모이어티로 표지처리하였다.
표 1: 정량적 (프로브 기반) PCR 구성품
Figure pct00013
* 염료/소거제 없이 뉴클레오티드 서열만 제시함
** 각 프로브에 사용된 염료/소거제는 '[ ]' 안에 표시함
표 2: 열순환기(Thermocycler) 제원
Figure pct00014
[196] 이 실시예에서 사용된 상이한 메틸화 기반 DNA 검출 분석안은, 모체 DNA에서 저도 메틸화되고 태아 DNA에서 과다 메틸화되는 것으로 기술된 2개의 마커 DMR에 기초하며(Nygren 외, 2010: Clin Chem 56, 1627; Chan 외, 2006:Clin Chem 42, 2211; Chiu 외, 2007:Am J Pathol 170, 941), 아울러 그들의 DMR의 약 20bp 내지 20kb 사이에 위치하는 모체 및 태아의 DNA 사이에 상이하게 메틸화되지 않는 두 개의 타영역(OR)에 기초한다. 특히, RASSF1A에 있는 메틸화 불감응 유전자좌위(locus)는 RASSF1A에 있는 메틸화 감응 유전자좌위의 하류로 8kb 내지 9kb 사이(8.97 kb)에 위치하며, TBX3에 있는 메틸화 불감응 유전자좌위는 TBX3에 있는 메틸화 감응 유전자좌위의 하류로 10kb 내지 llkp 사이(10.64 kb)에 위치한다. 도 2는 이 실시예에서 이용된 2개의 DMR 및 2개의 타영역의 각각의 배치 및 검출 양식을 도시한다.
[197] 표준으로서 농도를 알고 있는 남성 게놈 DNA(Promega)의 시리얼 딜루션(serial dilution)을 템플릿으로 사용하여 병렬 프로브(parallel probe) 기반의 정량화 PCR 반응을 수행하였다(동일한 PCR 실행(run) 내에서 별도로 반응시킴). VIC 채널(OR들. 즉 총 cfDNA 검출) 대비, FAM 채널(DMR. 즉 태아 cfDNA 검출)에서의 신호들을 상대적 정량화하여 cfDNA의 태아분을 계산하였고, 기지 농도의 표준 DNA의 딜루션 시리즈에서 얻은 VIC 채널에 비교하여 시료에서 얻은 VIC 채널의 신호들을 절대적 정량화하여서 총 cfDNA의 절대적 양을 계산하였다. 이러한 상대적 및 절대적 정량화는 LightCycler 480 소프트웨어 릴리스 1.5.0(Roche)을 사용하여 수행하였다.
[198] 태아 이수성의 확인을 위한 모체 혈장 DNA 시퀀싱 및 데이터 분석:
[199] Illumina의 NEBNext Ultra™ DNA 라이브러리 준비 키트를 사용하여 DNA 시퀀싱 라이브러리를 준비했다. 라이브러리는 Hamilton STARplus 로봇에 자동화된 제조자 프로토콜에 따라 준비하였다. 라이브러리의 질(quality) 및 양(quantity)은 Bioanalyzer 장비(Agilent) 및 Qbit 형광측정기(Invitrogen)를 사용하여 측정하였다. 라이브러리에 기초하여 정량화 딜루션 및 동몰의(equimolar) 시료 풀(pool)(풀당 시료 12개)을 준비하였다. 시료 풀의 시료들을 Illumina HiSeq2000 시퀀서의 Illumina v3 플로우 셀의 한 레인에서 시퀀싱했다. 제조자 프로토콜에 따라 cBot 클러스터 생성 시스템에서 TruSeq SR 클러스터 키트 v3-cBot-HS를 사용하여 클론 클러스터를 생성하였다. 이전에 설명한대로 태아 염색체 이수성을 확인하기 위한 생물 정보학 분석을 수행하였는데, 여기서 z스코어≥3이면 태아의 21번 삼염색체가 존재함을 지시하는 것이다(Stumm 외 2014, Prenat Diag 34:185). 이러한 NGS 기반의 방법으로 태아 이수성의 양성 결과가 나온 경우, 이 결과를 침습적 진단법으로 재확인하였다.
[200] 결과:
[201] 특징, 본 실시예의 방법에 의해 결정된 cfDNA의 % 태아분, 및 NGS에 기초한 방법에 의해 혈액 시료에 대해 결정된 이수성 검사 결과가 표 3에 제시되어있다. 태아의 21번 삼염색체를 나타내는 2가지 양성의 NGS 기반 검사 결과가 나와 있다. 두 결과 모두를 양수천자 후에 핵형 검사(karyotyping)로 확인한 결과, NGS 기반 연구에서의 거짓양성율은 0%였다. 단융모막 쌍태아를 나타내는 하나의 혈액 시료는 일치 핵형(concordant karyotypes) [47, XY, +21]을 갖고 2융모막 쌍태아를 나타내는 다른 시료는 불일치 핵형(discordant karyotypes) [47, XY, +21 및 46, XX]을 갖는다. 두 시료에서 태아분은 각각 18.0 및 24.8%이었다. 다른 모든 NGS 기반 NIPT 결과는 21번, 18번, 13번 삼염색체 대해 음성이었다. 지금까지 본 연구에 포함된 임신에서 거짓음성 NIPT 결과의 증거는 없다.
표 3: 채집된 혈액 시료의 특징 및 NIPT 결과
Figure pct00015
[202] 선행 기술의 NGS 기반 NIPT에 의한 쌍태 임신에서의 태아 이수성의 신뢰성있는 검출은 각 태아로부터의 충분한 양의 태아 cfDNA가 모체 혈액 내에 있을 것에 의존한다. 태아분 cfDNA의 하한치를 각 쌍태아의 기여분이 검출 임계값을 초과하지 않도록 보장하도록 정의하는 방법에 대한 여러 데이터 및 고려 사항이 발표된 바 있다(Leung 외, Prenat Diag 33:675; Qu 외 2007, Am J Pathol 170:941; Struble 외 2013, Fetal Diagn Ther 12월 7일 Epub 발행). 이는 불일치 핵형을 가진 2융모막 쌍태 임신에 특히 중요한다. 위에서 설명한 연구에서는 두 태아 중 하나만이 남자인 경우 Y 염색체 재현(Y-chromosomal representation)에 의해 도출된 쌍태 임신에 대한 최소 태아분 cfDNA의 정의를 뒷받침하는 정보가 사용되었다. 본 실시예의 방법을 이용하여, 두 태아로부터 유래된 태아 cfDNA의 요약을 반영하는 총 태아분 cfDNA를 결정할 수 있다. 차세대 시퀀싱의 Y 염색체 재현을 사용하여, 태아 cfDNA 양을 남자 태아에 대해 결정할 수 있다(Stumm 외 2014에서 설명). 따라서, 혼성 태아의 경우, 각 태아의 기여 정도는, 본 실시예의 방법으로 측정된 태아분 cfDNA에서 Y 염색체 재현에 의해 결정된 태아 cfDNA의 양을 뺌으로으로써 결정될 수 있다. 본 실시예의 방법에 의해 결정된 태아분 cfDNA를 성별이 알려진 경우의 차세대 시퀀싱의 Y 염색체 독출(reads)에 의해 얻어진 값과 비교하였다(도 3 참조). 본 실시예의 방법에 의해 측정된 태아분 cfDNA(x축)에 대한, 남성 특이적 cfDNA의 양(y축)은 상관 관계가 있다. 따라서, 남/남 성별의 쌍태 임신의 경우에 [y=x]는 거의 사실이고, 여/남 성별의 경우에는 [y=0.5x]가 거의 사실이고, 여/여의 경우에는 [y=1]이 거의 사실이다. 비슷한 값을 갖는 경우의 성별은 남/남이고, 낮은 Y 염색체 재현을 갖는 값이 다른 경우에 성별은 여/여이다. Y 염색체 재현보다 태아분의 %가 절반 정도를 나타내는 중간 경우는 혼합 성별이다. 도 3에 제시된 데이터는, 쌍태 임신의 경우에 선행 기술인 NGS 기반 NIPT 결과를 사용하여 태아 성별을 판단하는 것이 가능할뿐 아니라 본 실시예 방법에 의해 결정된 cfDNA 태아 분의 측정량이 Y 염색체 서열의 빈도수에 비하여 정확하다는 것을 나타내준다. 한편, 이들 데이터는 쌍태 임신의 각 태아가 총 태아분 cfDNA의 대략 절반에 기여한다는 가설을 뒷받침한다. 이것은 쌍태 임신의 경우에 태아 cfDNA 양의 두 배가 필요할 것이며, 따라서 쌍태 임신에 대한 선행 기술의 NGS 기반 NIPT를 위해서 권장되어야 할 최소의 cfDNA 태아분은 8%로 간주될 수 있을 것이라는 결론을 이끌어 낸다.
[203] 일치 유전자형 단융모막 쌍태 임신의 경우에는 (드물게 예외적인 경우를 제외하고는)(Chen 외, 2013, Am J Med Genet A 161A:1817 참조), 4%의 cfDNA 태아분이면 단태 임신과 마찬가지로 태아 이수성을 검출하기에 충분할 것이다. 그러나 일상적인 실험실 NIPT의 경우, 한 가지 주요 쟁점은 단융모막 및 2융모막 임신에 대한 상이한 질적 기준의 함의에 대한 것이다. 융모막 임신의 판정은 재태연령(gesdtational age)과 초음파검사 수행 의사의 실제 경험에 좌우된다. 융모막 임신 여부는 다태 임신의 최초 3분기(1/3분기)에는 명확하게 감지할 수 있지만 이후 단계에서의 감지는 더 어려워진다(Sperling 외 2001, Acta Obstet Gynecol Scand 80:287). 따라서 쌍태 임신의 경우에는 최소 태아분 cfDNA를 포괄적으로 정의하는 것이 더 안전한 전략이며, 이는 단융모막 및 2융모막 다태 임신에 적용가능하다.
[204] 쌍태아 소실의 확인:
[205] 본 실시예의 방법을 이용하여 태아분 cfDNA를 측정한 NIPT 이수성 검사의 2가지 사례에서 21번 삼염색체가 확인되었지만(각각 z스코어 13.5 및 3.4),아울러, 본 실시예 방법에 의해 측정된 총 태아분 cfDNA와 Y 염색체 재현에 의해 측정된 태아 cf-DNA 양 사이에 큰 불일치가 관찰되었다.
[206] 사례 A의 경우, 두 가지 혈액 시료(제1시료 및 백업 시료)의 분석 결과, 본 실시예의 방법에 의해 각각 20.7% 및 24.8%로 총 태아분 cfDNA가 추정된 반면, 차세대 시퀀싱에서의 Y 염색체 재현에 따른 태아 cfDNA는 각각 9.2% 및 9.3%였다. 임신이 혼성의 쌍태 임신일 수 있다고 추측되었고, 이는 임신 10주에 행한 초음파 스캔 중에 쌍태아의 사망이 관찰되었다고 확인한 의사에게 보고되었다. 임신 3기(3/3분기)에 채취한 추가 혈액 시료(38+2)는 21번 삼염색체에 대해 음성으로 밝혀졌고, Y 염색체 시료에 의해 측정된 태아의 cfDNA 양은 QuantYfeX로 측정한 양과 상관 관계가 있어서(21.7% 및 21.4), 살아 있는 태아의 핵형에 의해 판정된 남성 성별과 일치하였다. 출산시 태반 조직에서 지상 태아(foetus papyraceous)가 발견되었는데, 이로부터 충분한 양의 세포를 분리하여 세포 배양하였고 GTG 밴딩을 수행하여서 21번 삼염색체가 양성이며 여성 핵형이 확인되었다(47, XX, +21).
[207] 사례 B의 경우, 약간 증가된 Y 염색체 재현이 모니터링되었는데, 이는 남성 특이적 태아 cf-DNA가 각각 3.0% 및 2.7%임을 나타낸다. 본 실시예의 방법으로 측정한 태아분 cfDNA의 추정치가, 태아분의 측정 불일치로 인해 우리가 가정했던 것(13.4% 및 10.0%)을 훨씬 상회했기 때문에, 이들 불일치한 성별을 갖는 두 태아가 태아분에 영향을 주고 남자 태아가 21번 삼염색체의 영향을 받게 된다. 이러한 논제는 대략 3%의 Y 염색체 특이적 태아 cfDNA 양과, 3.0의 차단값(cut-off value) 주변에서의 증가된 z스코어와의 상관관계로부터 도출된 것이었다. 단태 임신에 대해서 이 검사가 분명하게 요구되었기 때문에, 남성 특이적 태아 cfDNA가 소실 쌍태아 ― 어쩌면 21번 삼염색체의 보유자 ― 에서 유래한 것으로 의심되었는데, 이는 인지하지 못하였고 NIPT 동의서 양식에 표시되어 있지도 않았다. 따라서 결과가 염색체 21번에 대해서는 결정적이지 못하다고 보고하였고, 이 상충하는 데이터를, 잠재적 쌍태아 소실에 관한 고지를 포함하여, 담당 의사에게 보고하여서 초음파를 통한 추가적 확인을 할 수 있도록 하였다. 이후에 담당 의사는, 임신이 쌍태아 임신으로 시작되어 나중에 단태 임신으로 계속되었음을 확인하였다. 생존해 있으며 확연하게 건강한 태아의 성별은 여자이며 따라서 21번 삼염색체에 대해 z스코어를 증가시킨 태아 cfDNA는 분명히 사망한 남자 태아에게 할당될 수 있음이 확인되었다.
[208] 실시예 2(비교예): 2개의 상이한 메틸화 영역을 이용하되 각 상이한 메틸화 영역에 대해 동일한 검출가능 모이어티(moiety)를 사용하여 기준 염색체의 검출 감도를 향상시켰다.
[209] 본 발명자들은 두 DMR(및 상이하게 메틸화되지 않은 2개의 타영역(OR)) 각각에 동일한 검출가능 모이어티를 사용하여 이들 DMR을 검출하는 복합적다중 반응이, 각각 별도의 PCR 반응에서 하나의 DMR(및 하나의 OR)을 검출하는 종전의 검출 반응보다도 태아에서 유도된 기준 염색체를 검출하는 데 더 민감하다는 것을 관찰하였다(도 4 참조).
[210] 상이한 메틸화 기반 DNA 검출의 또다른 방법에서, 인간 염색체 3 및 12번에 각각 위치하는 2개의 DMR(실시예 1에 기술된 바와 같이 RASSF1A 및 TBX3에서 발견된 것)이, 동일한 DNA 분취량 및 반응으로 ― (정량적 프로브 기반(TaqMan)의 PCR을 사용하여서) 유효하게 동시에 ― 검출되었다. 그리고 2개의 OR(실시예 1에 기술된 바와 같이 RASSF1A 및 TBX3에서 발견된 것)도 동일한 검출가능 모이어티를 상기 각 DMR에 사용하여(그리고 적어도 하나의 OR에 사용된 검출가능 모이어티는 상기 DMR에 사용된 검출가능 모이어티와 다른 것임)함께 검출되었다. 비교하자면, 태아에 의해 유도된 기준 염색체의 cfDNA에서의 검출은, 각 DMR(및 상응하는 OR)이 별개의 반응에서 독립적으로 검출되는 경우에, 더 높은 사이클 수(Cp)에서의 검출이 나타내는 바와 같이 감도가 더 약했다. 영역/마커, 프라이머/프로브, 및 검출 방법은 실시예 1에서 기술된 것과, 단일 유전자좌위 반응의 경우에 특정 유전자(RASSF1A 또는 TBX3)로부터의 DMR(및 상응하는 OR)만이 단일 반응에서 동시에 검출된 것을 제외하고는, 실질적으로 같았다.
[211] 반면에, 다른 검출가능 모이어티(예를 들어, RASSF1A 좌위에 대한 FAM 및 TBX3 좌위에 대한 VIC)를 사용한 두 DMR의 다중 반응을 이용한, 태아 유도된 기준 염색체의 cfDNA에서의 검출은 한층 더 감도가 낮고(그리고 임의의 OR과 동시에 검출되는 것은 어렵다고) 판명되었는바, 이는, 이론적인 것을 따를 것도 없이, 색상 보정의 높은 복잡성, 개별적으로 검출 가능한 형광성 마커 개수의 제한성, 그리고/또는 동일한 반응에 존재하는 많은 형광성 마커들로부터의 '표백' 효과 때문인 것으로 여겨진다.
[212] 정량화 PCR 검출의 지수함수적 성질을 감안할 때, 높은 검출 감도(즉, 낮은 싸이클 수)는, 표준 곡선에 대한 보정과 같이, 높은 정량화 정확도와 동일시할 수 있을 것이다. 그리고 데이터 포인트들 간의 보간(interpolation)은 높은 싸이클 수에서의 검출과 관련이 있는, DNA의 양(즉, 기준 염색체의 정량화 양)에 의해 증가하는 오류보다 더 오류가 적게 될 것이다.
[213] 실시예 3(비교예): 자간전증을 앓거나 발병할 임신여성의 위험 증가를 감지하기 위한 상이한 메틸화 기반 DNA 정량화 방법의 사용(예언적 실시예. prophetic example).
[214] 비교예의 방법을 사용하여 임신여성이 자간전증을 앓고 있는 또는 발병할 위험을 다음과 같이 평가한다. 우선, 실시예 1에 기술된 절차를 실질적으로 따라, 상기 위험성 평가 대상 여성에게서 혈액 시료를 채취하고 이 시료의 혈장으로부터 총 cfDNA를 추출한다. 둘째, 실질적으로 실시예 1에 기술된 바와 같은 방법을 사용하여, 혈장에 존재하는 태아 cfDNA 및 총 cfDNA의 상대적 양 및/또는 절대적 양을 결정한다. 여기서 태아 및/또는 총 cfDNA의 절대적 양은 게놈 등가량('Eq')으로 표현될 수 있다. 셋째, 태아 cfDNA 및/또는 총 cfDNA의 상기 결정량을 임계값 또는 양의 기준 분포과 비교하여, 태아 cfDNA 또는 총 cfDNA의 양이 임계값을 넘고/넘거나 기준 분포 밖의 이탈값인 경우에 해당 여성이 자간전증을 앓고 있는 또는 발병할 위험이 증가하고 있다고 판단한다.
[215] 예를 들어, 공개된 임계값(Papantoniou 외, 2013, Prenat Diag 33:682)을 사용하여, 만약 총 cfDNA가 약 7,500Eg/mL 혈장의 양을 초과하거나 태아분 cfDNA가 약 500Eg/mL 혈장의 양을 초과하면, 해당 여성은 상기 위험이 증가하는 것으로 판정된다. 이 대신에 또는 이에 추가적으로 상기 위험은 아래와 같은 방법으로 평가할 수도 있다. 즉, (i) 태아 cfDNA(해당 여성에 대하여 임계값과 비교하여 결정된 양)의 배수 증가(예를 들어, 1.5, 3, 3.5배, 또는 4배 증가)를 고려하되, 후기 임신의 경우에 태아 cfDNA의 배수 증가가 더 크다는 것을 결정 요소로 넣는다(Zeybek 외, 2013, J Obstet Gynaecol Res 39:632), 그리고/또는 (ii) 저 위험 여성 또는 자간전증을 겪지 않았거나 발병하지 않은 여성에게서 결정되는 양의 기준 분포를 고려할 때 여성에서 결정된 cfDNA의 양의 백분위수(percentile)가 감소하는지를 고려하여서 평가할 수 있다. 예를 들어, 만일 태아분 cfDNA가 이 양의 기준 분포의 90번째 백분위수(90th percentile) 이내에 있다면 이 여성은 경증 또는 중증의 자간전증을 앓을 위험이 증가한 것으로 간주될 수 있다(Jakobsen 외, 2013, Transfusion 53:1956).
[216] 이 예에서, 이러한 위험의 감지는 도 5에 나타낸 연산을 실행하는 컴퓨터 프로그램 제품을 사용하여 수행된다. 연산 (A)에서는 컴퓨터 프로그램 제품을 사용하여 각각 태아 cfDNA 및 총 cfDNA를 나타내는 신호 (1) 및 (2)를 수신하여 여성의 혈장에 존재하는 태아(또는 총) cfDNA의 상대적 양 및/또는 절대적 양을 나타내는 파라미터(4)를 결정한다. 이 연산은 선택사항으로서, 표준 DNA의 절대적 양을 나타내는 신호(3)를 수신할 수 있다. 두번째 연산 (B)에서는 임계값(5) 및/또는 기준 모집단의 양(6)에 대해 상기 결정된 파라미터(4)를 비교하여, 해당 여성이 자간전증을 앓고 있는 또는 발병할 위험이 증가하는 것이 판단되는지를 결정하고 보고한다(7).
[217] 실시예 4: 21번 삼염색체를 검출하기 위한 직접적이고 효율적인 NIPT 검사법으로서 본 발명 방법을 이용
[218] 본 발명은 21번 삼염색체의 태아를 수태한 임신여성으로부터 얻은 cfDNA 시료를 식별할 수 있었다.
[219] 본 발명 방법의 1회의 다중 PCR 반응에서, 58명의 임신여성으로부터 수득한 cfDNA 시료에 존재하는 태아 염색체 21번 DNA 종의 양을 2개의 표적 DMR 각각에서 측정하였고, cfDNA 시료에 존재하는 태아 염색체 5 및 12번(기준 염색체임)의 기준 DNA 종의 양을 두 개의 기준 DMR을 이용하여 각 임신여성에 대해 측정하였다(도 6 참조). 태아 염색체 21번 종(두 표적 DMR 각각에서 추정됨)과 상기 태아 염색체 기준 종(두 기준 DMR 모두에 의해 추정됨)의 상대적 양을 비율값으로 계산하였고, 각 비율값을 사용하여 각 임신여성 인간별로 두 비율값 각각의 시료 특이적 평균값(n = 6개의 복제본)을 나타내는 산포도를 그렸다(도 7). 이 산포도에서는 21번 삼염색체('T21')가 있는 태아를 임신한 것으로 알고 있는 여성에게서 취한 시료를 나타내는 세 개의 '+' 점이 이탈값(outlier)으로서 표시되어 있음을 쉽게 알 수 있다. 이 산포도는 또한 염색체 21번 상의 하나의 표적 DMR(다른 표적 DMR은 아님)에 대한 이탈값으로서 하나의 Non-T21 시료가 관찰된다는 점에서 본 발명 방법의 하나의 유리한 특징을 증명해준다. 적어도 두 개의 이러한 마커를 분석할 수 있는 방법 및 분석법(가령, 본 발명 방법) 만을 사용함으로써, 이 시료가 T21 시료가 아닌 Non-T21 모집단 중의 이탈값이라는 것을 정확하게 식별할 수 있을 것이다. 예를 들어, x축에 나타낸 표적 DMR만을 고려하였거나 두 표적 DMR의 평균을 고려(즉, 표적 DMR을 함께 고려)하였다면, 그 시료는 T21 시료인 것으로 잘못 식별되었을 것이다.
[220] 도 7에 도시된 데이터는 단일 qPCR 실행시에 58명의 임신여성으로부터 취한 모든 58개의 시료로부터 만들어졌다. 그러나, 110명의 임신여성에서 채취한 추가분 110개의 시료를 2회의 추가 qPCR에서 동일한 본 발명 방법으로 분석하되, 각회의 qPCR에서 각각 54명과 56명의 임신여성의 시료를 분석하였다. 세 번의 검사 실행에서 생성된 데이터를 정규화하여서, 총 168개의 시료 모두를 하나의 산포도로 표시할 수 있었다(도 8). Non-T21 시료로부터 9개의 T21 시료들 무리(예를 들어 점선 표시 곡선 경계로 구분)가 분리되어 있음이 명확하게 보여진다. 검사 실행들 간의 정규화는, 각 시료에 대한 각 비율값의 평균값으로부터, 이후에 설명한 것과 같이 단일 실행으로부터의 모든 복제본에 걸쳐 적용 가능한 비율의 중앙값을 뺌으로써 수행하였다. 정규화 결과값은 2를 더하여 양수 값으로 변환한 후에 로그 스케일을 사용하여 표시하였다.
[221] 도 9에서, 다수의 실행(이 실시예 3에서의)에 걸쳐서 다수의 시료(이 실시예에서는 168개)를 분석하는 데 있어서의 본 발명 방법의 강인성은, 실행 1 내지 실행 3 각각의 경우에, 전체 Non-T21 시료(도 9에서 '+'로 표시됨)로부터 9개의 T21 시료(도 9에서 'o'로 표시됨)가 실행에 관계없이 분리되는 것, 도 8에서 곡선 구획선의 중심점에서부터 각 포인트의 거리(이 실시예에서는 0.5, 0.55))가 실행에 관계없이 분리되는 것을 고려함으로써 증명된다. 9개의 시료 모두가 거짓음성이나 거짓양성의 결과없이 성공적으로 유형분류되었다.
[222] 태아 염색체 21 DNA 종의 양은 2개의 표적 DMR을 이용하여 결정하였다. 즉, (ⅰ) 인간 염색체 21q22.2에 위치한 DSCAM 유전자(다운증후군 세포 접착 분자; NCBI 기준 서열 Homo sapiens 염색체 21, GRCh38.p2 프라이머리 어셈블리: NC_000021.9 GI:568815577, 영역 40010999~40847113; 서열번호 200)에 위치한 상기 제1 DMR, 및 (ii) 인간 염색체 21q22.2에 위치한 C21orf57(YBEY; 염색체 21: 46,286,337~46,297,751 정방향 가닥, GRCh38:CM000683.2; 250bp의 상류/하류 flaking 영역을 포함한 유전자, 서열번호 218)의 상류/하류로 약 250bp 이내에 위치한 제2 DMR.
[223] 태아 기준 염색체 DNA 종의 양은 2개의 기준 DMR을 이용하여 결정되었다. 즉, (i) 인간 염색체 12q24.21에 위치한 TBX3 유전자(전술함)에 존재하는 제1 DMR. 및 (ii) 염색체 5q31.3에 위치한 PCDHGA1 유전자(protocadherin gamma 서브패밀리 A, 1; NCBI 기준 서열 Homo sapiens 염색체 5, GRCh38.p2 프라이머리 어셈블리: NC_000005.10 GI:, 영역 141,330,571 내지 141,512,981 서열번호 217)에 존재하는 제2 DMR. 또한 각각의 다중 반응에서 TBX3(전술함)에 있는 DMR로부터 약 10kb에 위치하는 제1 OR과 PCDHGA1에 있는 DMR로부터 약 300bp에 위치하는 제2 OR이 증폭되었다. 사용된 각 DMR(및 OR)의 서열은 표 4에 기재되어 있다.
표 4: 염색체 21번, 5번, 및 12번의 DMR과 OR
Figure pct00016
메틸화 감응 부위에 밑줄 표시하였으며 기지의 SNP의 위치는 소문자로 표시하였음
[224] 168명의 임신여성 인간으로부터의 cfDNA 시료(T21을 갖는 태아를 임신한 것으로 알고 있는 9개를 포함)를 수집 및 준비하고, 실시예 1에 기재된 바와 같이 CpG 메틸화 감응성 효소 HhaI, HpaI, 및 BstUI로 분해(digest)시켰다. PCR 완충액이 PerfeCTa MultiPlex qPCR ToughMix(Quanta Biosciences)인 것을 제외하고는 실시예 1에 기재된 바와 같은 시료 각각의 복제본(n=6)에 대해서 표 4에 기재된 4개의 개별 유전자좌위의 다중 정량화 프로브 기반 PCR 반응을 수행하였다. 이때 표 5에 기재된 PCR 프라이머 및 표지처리된 프로브(소거제와 함께)를 사용하였고, 시료들을 각각 58개, 54개, 및 56개로 나누어서 3회 실행하였다. 본 발명의 분석법으로 구성된 각 실행(run)은 LightCycler 480II(Roche)가 포함된 384개 웰이 있는 마이크로타이터 플레이트(Roche) 하나에서 수행하였다.
표 5: 프라이머와 프로브
Figure pct00017
* 염료/소거제 없이 뉴클레오티드 서열만 제시함
** 각 프로브에 사용된 염료/소거제는 '[ ]' 안에 표시함
[225] 이러한 분석법의 형식은 전반적으로 도 6에 도시된 바와 같은데, 이 도 6의 DMR1은 인간 21번 염색체의 DSCAM 유전자에 위치하고, DMR2는 인간 21번 염색체의 C21orf57 유전자의 상류/하류로 약 250bp 내에 위치하고, DMR1'은 인간 12번 염색체의 TBX3 유전자에 위치하며, DMR2'는 인간 5번 염색체의 PCDHGA1 유전자 에 위치한다. 염색체 21의 표적 DMR과 염색체 5와 12의 기준 DMR 간의 상대적 양 또는 비율을 계산하는 목적상, OR은 마치 각 염색체의 태아분을 계산하는 데 사용하는 것처럼 필요치는 않으며, 그 값은 수학 공식에서 상쇄될 것이다. 따라서 OR의 사용으로부터 추정될 수 있는 총 DNA 양은 태아의 T21 상태를 분석하는 데는 필요하지 않지만 총 DNA에서 태아분의 cfDNA를 계산하는 데는 사용할 수 있다. 예를 들어 실시예 6 및/또는 7에 기술된 목적을 위해, 그리고/또는 가능한 또는 부가적인 품질 관리 수단(예, 실시예 6)으로서, 또는 실시예 7에 기술된 바와 같은 다른 진단의 목적으로는 사용할 수 있다. 표 5로부터 관찰되는바, DSCAM에 위치한 21번 염색체 표적 DMR에 대한 프로브는 C21orf57의 상류/하류로 약 250bp 내에 위치한 21번 염색체 표적 DMR에 대한 프로브와 다르게 표지처리한다. 또한 TBX3에 위치한 기준 염색체 12번 상의 기준 DMR과 PCDHGA1에 위치한 5번 염색체 상의 기준 DMR은 동일한 표지(표적 DMR에 대한 것과는 상이함)로 표지처리한다. 마지막으로, 총 DNA의 추정에 필요한 경우, 두 개의 OR은 모두 동일한 표지로 표지처리하는데, 이 표지 역시도 다중 표지 분석에 사용된 다른 표지와는 다른 것이다. 전체적으로, 4개의 표지가 사용되는데, 이로써, 예를 들어, 각 qPCR 플레이트의 (실행)에 피검 시료로 제공될 수 있는 (실시예 1에서 기술된 바와 같은) 기지 농도의 표준 DNA의 딜루션시리즈로부터 수득된 각 DMR(또는 OR)에 대한 신호와, 시료로부터 온 각 DMR(또는 OR)에 대한 각 신호를 비교하여 21번 염색체의 양을 각 표적 DMR에 대해 독립적으로 추정할 수 있게 되고 기준 염색체의 양을 보다 감도높게 검출할 수 있다(실시예 2 참조). 이러한 상대적 및 절대적 정량화는 Roche의 LightCycler 480 소프트웨어 1.5.0판을 사용하여 수행되었다. 염색체 21번 표적 DNA의 + 종들의 %태아 cfDNA 각각과 두 기준 염색체 기준 DNA 종의 %태아 cfDNA의 시료 특이적 비율의 평균값(n= 6개 복제본)을 각 시료에 대해 계산하였고, 각 플레이트별로 모든 복제본의 전체 중앙값을 계산하였다. 분석결과는 상기한 바와 같았다.
[226] 실시예 5: 알고 있는 내부 정배수체 표준(internal euploid standards)을 참조하지 않고, NIPT에서 21번 삼염색체를 검출하기 위한 z스코어 분석의 반복.
[227] 반복적 z스코어 접근법을 적용하여 발명자는 z스코어 분석에서의 평균 및 표준편차의 추정시에 기지의 정배수체 시료를 참조하지 않고 피검 시료로부터 모든 알려진 21번 삼염색체 시료를 확인할 수 있었다.
[228] 실시예 4에서 분석된 시료의 각 실행(qPCR 플레이트)으로부터의 데이터를 하기와 같이 재분석하였다. 먼저, 시료의 각 복제본의 기준 염색체 DMR에 대한 각 염색체 21번 표적 DMR의 평균 비율(n=6)을 계산하였고, 이 실행(플레이트)에 존재하는 모든 시료에 대해 각 비율의 전체 평균 및 표준편차를 계산하되 시료가 정배수체인지 또는 삼염색체인지의 여부가 알려졌는지를 참조하지 않고 계산하였다. 두 번째로, 이러한 실행에 특화된 수단 및 표준편차에 기초하여, 실행시 존재하는 각 시료에 대한 각 표적 DMR과 연관된 각각의 비율에 대한 (실행에 특유한: run-specific) 별도의 z스코어들을 계산하였다. 세 번째로, 각 DMR에 대해 이들 비율이 1.95와 같거나 큰지를 확인하고, z스코어를 이탈하는 것으로 나타난 시료를, 두 표준 DMR 각각에 독립적으로, 후속해서 z스코어 계산 인자(실행에 특유한 평균 비율 및 표준편차)를 정하는 데 사용되는 각 기준 시료 세트에서 제외시켰다. 기준 데이터 세트 내의 나머지 시료들에 관한 데이터에 대해서, 각 표적 DMR에 독립적으로, 각 비율에 대한 두 번째 평균 및 표준편차를 계산하였고, 이를 사용하여 이들 데이터 세트 내의 모든 시료별로 각 비율의 두 번째 z스코어 분석을 수행하였다. 네 번째로, 결과로 나온 z스코어(즉, 첫 번째 제외 단계 이후 계산된 스코어)를 상기 세 번째 단계에서처럼 각 표적 DMR에 대해 독립적으로 이탈값을 확인하였고, z스코어가 1.95와 같거나 큰 시료들을 각 DMR에 대해 z스코어를 계산하는 데 사용한 기준 데이터 세트에서 제외시켰다. 그리고 세 번째 평균 및 표준편차를, 기준 데이터 세트 내의 나머지 시료에 관한 데이터에 대한 각 비율마다 각 표적 DMR에 대해 독립적으로 계산하였고, 이를 사용하여 상기 데이터 세트 내의 모든 시료의 각 비율별로 세 번째 z스코어 분석을 수행하였다. 이러한 반복 과정을 20회 반복하였고, 비록 한 번의 반복적 제외 단계 후에 각 시료의 z스코어가 다시 1.95 아래로 바뀌게 될 경우에도 각 DMR 기준 세트에서 한번 제외시켰던 시료는 기준 데이터 세트에 다시 포함시키지 않았다. 각각의 비율 및 시료에 대한 결과적인 시료 z스코어를 도 10에 나타내었는바, 이는 정배수체 및 T21 시료의 완전한 분리를 표시한다(두 비율 각각에 대한 약 3.0보다 큰 z스코어, 그리고/또는 약 3.0보다 큰 z스코어의 평균값, 그리고/또는 실시예 4와 도 9에 기재된 것과 유사한 데이터 무리 또는 거리 근접도에 의해 나타내어짐). 평균 z스코어 3보다 큰 값을 얻는 이배체(diploid) 이탈값은 규칙을 정하여서 제외시켰다. 즉, 불일치 결과들(마커 1 및 2)는 차이의 범위를 위해 조절하였다. 차이가 4.0 이상이라면, 이들은 양성이 아니며 보고필요성이 없다.
[229] 실시예 6: 태아분 cfDNA을 추정하기 위한 본 발명 방법의 사용.
[230] 임신여성으로부터 분리된 총 cfDNA에서 태아 DNA의 % 분율(태아분)을, 2개의 기준 염색체 상에 존재하는 2개의 (통상적으로 표지처리된) 기준 DMR 및 2개의 (통상적으로 표지처리된) OR(각 OR은 자신의 DMR과 동일한 유전자 내에 있음)을 사용하여 측정된 DNA 양의 비율을 계산하여 추정하였다. cfDNA의 태아분에 대한 정보는, 실시예 1에서 설명한 NGS 기반 분석법과 같은 후속 분석이 가능하도록 하기 위해 충분한 태아 DNA가 시료에 존재하는지 여부를 결정하는 등, 품질 관리 목적으로 사용될 수 있다.
[231] 실시예 7: 임신여성이 자간전증을 앓고 있는 또는 발병할 위험의 증가를 감지하기 위한 본 발명 방법의 사용(예언적 실시예)
[232] 임신여성에 수태된 태아가 이수성인지 여부를 결정하는 것 이외에, 실시예 4에 기재된 본 발명 분석의 포맷(즉, 총 DNA를 측정하기 위해 적어도 OR에 대해서 실시되는 포맷)은 또한, 임신여성이 자간전증을 앓고 있는 또는 발병할 위험을 판정하는 데도 사용된다.
[233] 실질적으로 실시예 4에서 기술된 바와 같은 방법을 사용하여, 혈장에 존재하는 태아 cfDNA 및 총 cfDNA의 상대적 양 및/또는 절대적 양을 결정하는데, 여기서 태아 및/또는 총 cfDNA의 절대적 양은 게놈 등가량(Eq)으로 표현될 수 있다 세 번째로, cfDNA 및/또는 총 cfDNA의 결정된 양을 임계값 또는 양의 기준 분포와 비교하여, 태아 cfDNA 또는 총 cfDNA의 양이 임계값을 초과하거나 기준 분포에서 이탈값인 경우에, 해당 여성이 자간전증을 앓고 있는 또는 발병할 위험이 증가한 것으로 판단한다. 공개된 값, 그리고 이러한 위험을 평가하는 다른 방법은 실시예 3에 기술된 것을 포함한다. 본 발명의 이러한 방법은 실시예 3에 기술된 (그릭 도 5로 나타내지는) 컴퓨터 프로그램 제품을 이용하여 이러한 위험을 감지하기 위한 신호를 생성하는 데 사용될 수 있다.
[234] 실시예 8: 본 발명의 키트의 제조 및 배포(예언적 실시예)
[235] 본 발명의 키트는 표 5에 기재된 프라이머 및 프로브 각각에 대한 완충액을 형성하여 제조한다. 각 완충액의 분취량(aliquot)(예를 들어, 200ul)을 별도의 에펜도르프 튜브에 넣고, 이 튜브를 카드보드 용기에 담는다.
[236] 이와 다른 키트로서, 표 5에 열거된 프라이머 및 프로브의 혼합물을 포함하는 단일 완충 용액을 제조한다.
[237] 또 다른 키트로서, 카드보드 용기에 표 5에 설명된 두 개의 제1 표적 DRM을 검출하는 데 사용되는 프로브의 분취량을 추가로 포함시킨다.
[238] 키트의 카드보드 용기는 또한 인쇄된 사용 설명서를 더 포함하여, 사용자에게 (다른 구성품과 함께) 해당 구성품을 사용하여 태아의 염색체 이수성을 검출하는 본 발명 방법의 실시를 위한 지침을 제공한다.
[239] 실시예 9: 수집된 시료를 사용한 시험(예언적 실시예)
[240] 이수성 또는 정배수성 태아를 지닌 것으로 알고 있는 다수의 임신여성으로부터 수집된 다수의 시료를 (실시예 4에 기술된 바와 같은 분석법을 사용함으로써) 본 발명 방법에 의해 분석하여 염색체 이수성(예를 들어, 21번 삼염색체)을 갖는 태아를 임신한 것으로 여겨지는 시료를 (예를 들어 정확하게) 찾는다. 단, 블라인드 검사 방식(즉, 검사자는 어느 시료가 어느 부류의 임신여성에서 채취된 것인지 모름)을 사용한다. 분석 수행 후, 시료를 공개하고(즉, NGS 및/또는 다른 검사에 의해 판단된 것과 같이 삼염색체 태아를 실제로 임신했는지를 공개), 이 정보를 비교하여 본 발명 방법에 대한 감도(sensitivity) 및 특정도(specificity)의 추정치 또는 척도를 생성한다.
[241] 실시예 10: 21번 삼염색체를 검출하기 위한 NIPT에 대한 직접적이고 효율적인 본 발명 방법의 그 밖의 구현형태들.
[242] DMR, OR, 및 형광 표지/소거제의 특정 조합을 사용하는 본 발명 방법의 유용성은 실시예 4에서 입증된다. 그러나, 본 발명자들은 이 방법이 DMR, OR, 및/또는 형광 표지/소거제의 다른 조합과 같은 특정 조합에 한정되지 않고 본 발명 방법이 NIPT에 의해서 21번 삼염색체를 직접적으로 그리고 효율적으로 검출할 수 있음을 보여준다는 것을 입증하였다. 표 6은 이러한 증명을 수행하기 위해 사용된 다양한 순열(permutation) 및/또는 조합을 나타낸다.
표 6: 본 발명 방법의 그 밖의 구현형태들의 요약(이들에 한정되지 않음)
Figure pct00018
* C21orf57 프로브를 위한 표지/소광제 쌍으로서 Cy5/BBQ650을 사용하는, 프로브의 제2 공급자
** 실시예 4와 비교하여 C21orf57 프로브를 위한 표지/소광제 쌍으로서 Cy5/BHQ3을 사용하는 것을 제외함
[243] 56 또는 58명의 임신여성에게서 각각 얻은 cfDNA 시료 세트를, 개별적인 qPCR 테스트 실행을 위해 많은 시료들 모음 중에서 선택하였다. 이때 각 검사 실행(run)에 21번 삼염색체를 가진 것으로 알고 있는(상용 차세대 시퀀싱 기반 NIPT 방법: PRENATEST®, LifeCodexx AG, 독일 콘스탄츠에 의해 미리 판정 및 확인된) 임신부로부터 채취한 2~4개의 cfDNA 시료를 포함시켰다.
[244] 실시예 4에 기술된 바와 같은 방법을 각 qPCR 검사 실행에 대해 실시하였고, 각 실행에서 얻은 검사 데이터를 분석하여 DMR 비율을 계산하고, 보정하고, 그리고 도 8에 도시된 것과 유사하게 제시하였다. 다만, 실시예 10에서 사용된 다양한 분석 구현형태의 경우에 표지(및 상응하는 소거제)의 상이한 순열을 사용한 것과, 두 경우에 제2의 Chr(염색체) 21번 DMR을 이용한 것은 제외하였다. 각각의 분석에 있어서, 표 6에 나타낸 것과 같은 DMR/OR을 이용하였다. 두 번째 컬럼에 기재된 분석법의 경우에는, 프라이머 서열, 프로브 서열, 및 프로브-표지/소거제의 조합은 실시예 4에서 사용했던 것 그리고 표 5에 제시한 것과 동일한 조합이다.
V10.1 내지 V10.4로 기술된 분석의 경우에, 실시예 4의 사용 및 표 5 기재와 동일한 프라이머 서열 및 프로브 서열을 사용하였지만, 프로브-라벨(및 이에 상응하는 소거제)은 표 6에 제시된 것을 사용하였다. V10.5 및 V10.6으로 기술된 분석의 경우에는 V10.1/10.4에서와 동일한 프라이머 서열, 프로브 서열, 및 프로브-표지/소거제를 사용하였지만, 단, C21orf57에 위치한 DMR 대신에 다른 제2 (표적) Chr 21 DMR을 이용하였다 ― V10.5의 경우 C21orf29, V2.6의 경우 CGI149. 이들 두 대안적인 제2 (표적) Chr21 DMR 각각의 서열을 표 7에 나타내었고, 이에 상응하는 프라이머 및 프로브 서열, 그리고 V10.5 및 V10.6에서 사용된 표지/소거제를 표 8에 나타내었다.
표 7: 다른 대안적인 염색체 21번 DMR
Figure pct00019
메틸화 감응 부위에 밑줄 표시하였으며 기지의 SNP의 위치는 소문자로 표시하였음
표 8: 대안적 염색체 DMR을 위한 프라이머와 프로브
Figure pct00020
* 염료/소거제 없이 뉴클레오티드 서열만 제시함
** 각 프로브에 사용된 염료/소거제는 '[ ]' 안에 표시함
[245] 도 11 내지 도 17(각각의 경우, x축은 DSCAM을 하나의 Chr21 DMR로 나타내고, y축은 다른 Chr21 DMR을 나타낸다)과 같이, 이들 상이한 구현형태 각각은, 각 실행에서 Non-T21 시료로부터 구별 가능하게 무리져 있는 바와 같이, 21번 삼염색체를 검출하는 NTPT를 위하여 본 발명이 직접적이고 효율적인 방법이 된다는 것을 증명하고 있다. 단지 하나의 분석 버전(V10.1)에서, 모든 분석에 적용된 동일한 사전정의된 원형의 컷오프 경계 외부에 있는 진정양성 시료에 의해 '거짓음성'이 일어난 것이 발견되었으며, 그리고 두 거짓음성 결과 중의 하나는 두 마커에 대해 상당히 높은 마커 비율을 가짐으로써 용이하게 미상인 것으로 확인되었다. 소수의 거짓양성이 일부 분석 실행시 정량화된 진정음성의 0% (V10.4 및 V10.5 경우) 내지 4% (V2.1 경우)까지 나타났지만, 당업자가 이해할 수 있는 바, 예컨대 이수성에 대한 진단 검사에서는 거짓양성보다 거짓음성이 최소일 것이 훨씬 더 중요하다. 이 실시예에서 사용된 사전정의 원형 컷오프 경계는 이전에 정의하였던 것으로, 실시예 4에서 설명한 분석 포맷에서 15개의 T21 시료를 포함한 700개가 넘는 시료를 사용한 대규모의 랜덤 블라인드 qPCR 검사 실행 세트로부터 얻어진 데이터를 분석한 후에, 이러한 검사에 대해 요구되는 총체적인 감도(진정양성 율), 특정도(진정음성 율), 및 보고불요 율(non-reportable rate) ― 예를 들어, 100%, 거의 100%, 97% 초과(바람직하게는 97.5% 초과), 또는 95% 초과의 감도; 95% 초과, 바람직하게는 96% 초과의 특정도; 및/또는 10% 미만(바람직하게는 7% 미만), 예를 들어 6% 또는 5% 미만의 보고불요 율 ― 을 제공하기 위해 정의했던 것이다.
[246] 실시예 11: 18번 삼염색체를 검출하기 위한 직접적이고 효율적인 NIPT 방법으로서의 본 발명 방법의 사용(예언적 실시예)
[247] 실시예 10에 기술된 하나 이상의 이수성-DMR/표지의 조합을, 하기에 간략히 기술한 것과 같이, 18번 삼염색체(T18)를 검출하기 위한 NIPT의 기초로 사용한다. T18 임신(희귀한 이수성) 여성으로부터 채취한 한정된 수의 시료를 사용하여, 예컨대 2개의 염색체 21 DMR 대신에 1개(또는 2개)의 18번 염색체 DMR을 이용한다는 것을 제외하고는 실시예 4 또는 실시예 10에 기술된 방법을 사용한다(또는 예를 들어 V10.3과 유사한 방법을 사용함). 예를 들어, 표 9에 기재된 두 염색체 18번 DMR을 이 분석에 이용할 수 있고, 상응하는 프라이머 및 프로브 서열, 그리고 사용되는 표지/소거제는 표 10에 기재되어 있다.
[248] 당업자라면 이제 알 수 있는 바, 이러한 분석에 사용될 수 있는 NFATC2 및/또는 chrl8-gr00094 유전자/영역의 정확한 영역, 그리고 상응하는 프라이머/프로브의 정확한 위치/서열을 추가적으로 최적화할 수 있다(예를 들어, 아래에서 설명할 영역 및 서열의 상류 및/또는 하류로 약 350bp, 300bp, 250bp, 200bp, 150bp, 100bp, 50bp, 20bp, 10bp, 또는 5bp 이내의 영역을 이용, 바람직하게는 약 350bp 내지 200bp, 또는 200bp 및 5bp 사이의 영역을 이용). 또한, 실시예 10에 기재된 것에 추가하여, 예를 들어 비메틸화된 cfDNA의 분해(digestion)를 향상시키기 위해 메틸화 감응성 제한효소를 추가로 사용할 수 있다. 이러한 추가적인 메틸화 감응성 제한효소에는 AciI, Cac8I, 및/또는 PhoI가 포함될 수 있다.
표 9: 염색체 18번 DMR
Figure pct00021
메틸화 감응 부위에 밑줄 표시하였으며 기지의 SNP의 위치는 소문자로 표시하였음
표 10: 대안적 염색체 DMR을 위한 프라이머와 프로브
Figure pct00022
* 염료/소거제 없이 뉴클레오티드 서열만 제시함
** 각 프로브에 사용된 염료/소거제는 '[ ]' 안에 표시함
[249] 이상에서와 같이, 본 발명은 또한 다음과 같은 사항들에 관련된 것임을 알 수 있을 것이다.
1. 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법으로서,
(a) 모체에서 유래한 상이하게 메틸화된 DNA와 혼합된, 태아의 세포 및/또는 태아의 태반으로부터 유래된 DNA를 포함하는, 상기 임신여성으로부터 채취한 시료를 제공하는 단계;
(b) 메틸화 및 비메틸화 DNA를 상이하게 변형시키는 시약으로 상기 시료에 존재하는 DNA를 처리하는 단계;
(c) 상기 시료에서 염색체 이수성과 관련된 염색체인 제1 표적 DNA 종의 양을 결정하되, 상기 염색체에 위치하는 둘 이상의 제1 표적의 상이한 메틸화 영역(제1 표적 DMR)에 메틸화가 존재하는지를 상기 시료에서 검출함으로써 결정 ― 여기서, 상기 제1 표적 DMR은 태아의 세포 및/또는 태아의 태반에서 유래한 DNA와 모체 유래 DNA 간에 상이하게 메틸화된 영역이고, 제1 표적 DMR의 DNA의 상기 시약에 의한 변형은 DNA의 메틸화에 감응하고, 상기 제1 표적 DMR 중 하나 이상에서의 메틸화 DNA의 검출량은 상기 시료 내의 상기 제1 표적 DNA 종의 양을 나타냄 ― 하는 단계;
(d) 상기 시료에서 하나 이상의 기준 염색체인 기준 DNA 종의 양을 결정하되, 상기 기준 염색체(들)에 위치하는 둘 이상의 기준 DMR에 메틸화가 존재하는지를 상기 시료에서 검출함으로써 결정 ― 여기서, 상기 기준 DMR은 태아의 세포 및/또는 태아의 태반에서 유래한 DNA와 모체 유래 DNA 간에 상이하게 메틸화된 영역이고, 상기 기준 DMR의 DNA의 상기 시약에 의한 변형은 DNA의 메틸화에 감응하고, 상기 기준 DMR 중 하나 이상에서의 메틸화 DNA의 검출량은 상기 시료 내의 상기 기준 DNA 종의 양을 나타냄 ― 하는 단계;
(e) 단계 (c)에서 결정된 양과 단계 (d)에서 결정된 양의 상대적 양(들), 바람직하게는 비율(들)을 결정 ― 여기서, 상기 하나 이상의 상대적 양(들)은 태아 내의 염색체 이수성의 존재 또는 부존재를 지시함 ― 하는 단계를 포함하되,
상기 단계 (c) 및 단계 (d)에서의 상기 검출은 상기 시료의 동일한 DNA 분취량(aliquot)을 사용하여, 그리고 동일 용기에서, 그리고 상기 제1 표적 DMR 및 상기 기준 DMR에 대해 유효하게 동시에 수행되며, 그리고 (x) 상기 기준 DMR의 적어도 두 개에 대해 동일한 검출 표지(들)를 사용하여서 그리고/또는 (y) 상기 제1 표적 DMR의 적어도 두 개에 대해 상이한 검출 표지(들)를 사용하여서 수행되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
2. 제1항목에서, 상기 기준 DMR 중 2개 이상은 상이한 기준 염색체에 위치하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
3. 제1항목 또는 제2항목에서,
(f) 상기 시료에서 총 DNA의 양을 결정하되, 태아의 세포 및/또는 태아의 태반으로부터 유래한 DNA와 모체 유래 DNA 간에 상이하게 메틸화되지 않은 적어도 하나의 타영역(OR)을 검출함으로써 결정 ― 여기서 상기 시약에 의한 OR(들)의 변형은 DNA 메틸화에 감응성이 없음 ― 하는 단계를 추가로 포함하되, 여기서 상기 단계 (c) 및 단계 (d) 및 단계 (f)에서의 상기 검출은 상기 시료의 동일한 분취량의 DNA를 사용하여 그리고 동일한 용기에서, 그리고 효율적으로는 상기 기준 DMR 및 상기 타영역에 대하여 동시에 이루어지며, 그리고 (x) 상기 기준 DMR의 적어도 2개 이상에 대해 동일한 검출 표지(들)가 사용되고, (y) 상기 제1 표적 DMR의 적어도 두 개에 대해 그리고 상기 OR의 적어도 하나에 대해 상이한 검출 표지(들)가 사용되며,
선택적으로(옵션사항으로), (A) 상기 OR은 하나 이상의 기준 염색체에 위치하되, 바람직하게는 상기 기준 DMR의 적어도 하나와 동일한 기준 염색체에 위치하는 상기 OR의 적어도 하나에 위치하고, 그리고/또는 (B) 상기 OR은 상기 기준 DMR 중 적어도 하나의 상류 또는 하류로 약 20bp 내지 20kb 사이에, 그리고/또는 상기 상기 기준 DMR 중 적어도 하나와 동일한 유전자 내에 위치하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
4. 제3항목에서,
(A) 단계 (f)에서의 상기 검출은 상기 OR들의 적어도 2개를 이용하는 것을 포함하되, 여기서, 바람직하게는, 상기 OR의 수는 단계 (d)에서 사용된 기준 DMR의 수와 동일하고, 보다 바람직하게는, 상기 OR들 중 하나는 단계 (d)에서 사용된 기준 DMR과 동일한 염색체에(특히, 이 기준 DMR의 상류 또는 하류로 약 20bp 내지 약 20kb 사이에) 위치하며, 상기 각각의 OR은 상기 기준 DMR 중의 다른 하나와 동일한 염색체에(특히, 이 기준 DMR의 상류 또는 하류로 약 20bp 내지 약 20kb 사이에) 위치하고, 그리고/또는
(B) 단계 (f)에서의 상기 검출은 (x) 상기 OR 각각에 대해 동일한 검출 표지(들)을 사용하여 수행되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
5. 제1항목 내지 제4항목 중 한 항목에서, 상기 검출 단계 (c) 및 단계 (d), 및 선택적 임의 단계 (f)는 상기 시료의 DNA의 동일 분취량을 사용하여 그리고 동일한 반응/검출 용기에서, 그리고 유효하게 서로 동시에, 그리고 상기 DMR 및 옵션으로 사용된 OR(들) 각각에 특화된 적어도 하나의 표지처리된 프로브를 사용하는 다중형 실시간 정량화 프로브 기반 PCR에 의해 수행되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
6. 제1항목 내지 제5항목 중 한 항목에서, 태아의 세포 및/또는 태아의 태반으로부터 유래된 상기 DNA 종은 순환 무세포 DNA이고, 상기 시료는 혈장 또는 혈장과 같은 부분혈인, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
7. 제1항목 내지 제6항목 중 한 항목에서, 메틸화 및 비메틸화 DNA를 상이하게 변형시키는 상기 시약은 (A) 바이설파이트, 또는 (B) 메틸화 DNA보다 비메틸화 DNA를 선택적으로 분해(digest)시키는 제제를 포함하되, 바람직하게, 이 제제는,
- 적어도 하나의 메틸화 감응성 효소.
- 적어도 하나의 메틸화 감응성 제한효소. 및/또는
- AatII, AciI, AclI, AfeI, AgeI, AgeI-HF, AscI, AsiSI, AvaI, BceAI, BmgBI, BsaAI, BsaHI, BsiEI, BsiWI, BsmBI, BspDI, BsrFI, BssHII, BstBI, BstUI, ClaI, EagI, FauI, FseI, FspI, HaeII, HgaI, HhaI, HinPlI, HpaI, Hpy99I, HpyCH4IV, KasI, MluI, NaeI, NarI, NgoMIV, NotI, NotI-HF, NruI, Nt.BsmAI, Nt.CviPII, PaeR7I, PluTI, PmlI, PvuI, PvuI-HF, RsrII, SacII, SalI, SalI-HF, SfoI, SgrAI, SmaI, SnaBI, TspMI, 및 ZraI로 이루어진 군에서 선택된 제제를 포함하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
8. 제1항목 내지 제7항목 중 한 항목에서, 하나의 기준 DMR은 인간 염색체 5번에 위치하고 또 다른 기준 DMR은 인간 염색체 12번에 위치하며; 바람직하게는, 상기 제1 표적 DMR의 각각은 인간 염색체 21번, 염색체 18번, 또는 염색체 13번에 위치하되, 바람직하게는 염색체 21번에 위치하고; 선택사항으로, (A) 상기 DMR은 태아 DNA에서 과다 메틸화되고 모체 DNA에서 저도 메틸화되며, 그리고/또는 상기 DMR은 상기 시약에 특이적인 적어도 하나의, 바람직하게는 적어도 둘의 메틸화 부위를 포함하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
9. 제1항목 내지 제8항목 중 한 항목에서,
(A) 상기 제1 표적 DMR들은 각각,
- WO 2011/092592의 EP1, EP2, EP3, EP4, EP5, EP6, EP7, EP8, EP9, EP10, EP11, 및 EP12(서열번호 33~44)로 이루어진 목록 중에서 선택된 것을 포함하여, WO 2011/092592에 개시된 영역 및/또는 유전자; 또는
- AIRE, SIM2, 및 ERG 중에서 선택된 영역 및/또는 유전자, 또는 이 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열; 또는
- PDE9A, PPP1R2P2, CBR1, DSCAM, C21orf29, 및 HLCS 중에서 선택된 영역 및/또는 유전자, 또는 이 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열; 또는
- C21orf57의 영역 및/또는 유전자, 또는 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열; 또는
- WO 2011/034631의 서열번호 33, 34, 35, 36, 37, 38, 39, 176, 179, 180, 184, 188, 189, 190, 191, 193, 195, 198, 199, 200, 201, 202, 203, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 221, 223, 225, 226, 231, 232, 233, 235, 239, 241, 257, 258, 259, 및 261 중에서 독립적으로 선택된 영역 및/또는 유전자에 위치하고, 또는,
(B) 상기 제1 표적 DMR들은 각각,
- VAPA-APCDDI의 영역 및/또는 유전자 또는 이 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열; 또는
- maspin의 영역 및/또는 유전자 또는 이 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열; 또는 -WO 2011/034631의 서열번호 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 및 32 중에서 독립적으로 선택된 영역 및/또는 유전자에 위치하고, 또는,
(C) 상기 제1 표적 DMR들은 각각, WO 2011/034631의 서열번호 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 및 20 중에서 독립적으로 선택된 영역 및/또는 유전자에 위치하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
10. 제1항목 내지 제9항목 중 한 항목에서, 상기 기준 DMR들은 각각,
- RASSF1A, TBX3, ZFY, CDC42EP1, PCDHGA1, SOX14, 및 SPN 중에서 선택된 영역 및/또는 유전자, 또는 이 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열; 또는
- WO 2011/034631의 서열번호 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 및 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 및 163 중에서 독립적으로 선택된 영역 및/또는 유전자에 위치하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
11. 제1항목 내지 제10항목 중 한 항목에서,
(A) 상기 제1 표적 DMR들의 하나는 DSCAM에 위치되고 제1 표적 DMR들의 다른 것은 C21orf57에, 또는 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp을 넘지 않는 DNA 서열에 위치하고,
(B) 상기 기준 DMR들 중 하나는 TBX3에 위치하고 상기 기준 DMR 중 다른 것은 PCDHGA1에, 또는 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp을 넘지 않는 DNA 서열에 위치하고; 바람직하게는, (i) 상기 제1 표적 DMR 중 하나는 서열번호 201을 포함하고, 상기 제1 표적 DMR 중 다른 것은 서열번호 219를 포함하며, (ii) 상기 기준 DMR 중 하나는 서열번호 203을 포함하고 상기 기준 DMR 중 다른 것은 서열번호 220을 포함하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
12. 제1항목 내지 제11항목 중 한 항에서,
(A) 단계 (c) 및 단계 (d), 및 선택적 임의 단계 (f)에서 다수의 결정 세트가 수행되되, 이 결정 세트에 속하는 각 결정은 상기 시료의 DNA의 상이한 분취량을 사용하여 상이한 용기에서 그리고 다수 결정 세트에 속하는 각 결정에 대해 유효하게 동시에 수행되고,
(B) 단계 (e)에서 결정되는 상대적 양(들) 또는 비율(들)은 단계 (c) 및 단계 (d) 그리고 선택적 임의 단계 (f)에서 수행된 다수의 결정 세트에 의해 결정되되, 바람직하게는 각 세트에서 결정된 DNA의 평균 양, 특히, 각 세트에서 결정된 DNA 양의 평균값, 중앙값, 또는 최빈값, 바람직하게는 각 세트에서 결정된 DNA 양의 평균값을 사용하여 결정되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
13. 제1항목 내지 제12항목 중 한 항목에서,
(A) 제1 표적 DNA 종의 양은 제1 표적 DMR 중 하나에서의 메틸화 검출량으로부터 결정되고, 제1 표적 DNA 종의 양은 제1 표적 DMR 중 다른 것에서의 메틸화 검출량으로부터 결정되고,
(B) 단계 (e)에서 둘 이상의 상대적 량(들), 바람직하게는 비율(들)은 제1 표적 DNA 종의 둘 이상의 양에 대해 결정되되, 각각은 하나 이상의 상기 제1 표적 DMR에 대하여 결정되고,
(C) 상기 둘 이상의 상대적 양(들) 또는 비율은 태아 내 염색체 이수성의 존재 또는 부존재를 지시하되; 바람직하게는, 상기 단계 (e)에서, 상기 둘 이상의 상대적 양(들) 또는 비율(들)을 임계값(들) 및/또는 기준 분포(들)와 비교시에, 상기 둘 이상의 상대적 양(들) 또는 비율(들)이 상기 임계값(들) 및/또는 기준 분포(들)보다 높거나 낮은 것은 태아 내의 염색체 이수성의 존재를 지시하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
14. 제1항목 내지 제13항목 중 한 항목에서, 상기 단계 (e)에서, 상기 상대적 양(들) 또는 비율(들)을 임계값(들) 및/또는 기준 분포(들)와 비교시에, 상기 상대적 양(들) 또는 비율(들)이 상기 임계값(들) 및/또는 기준 분포(들)보다 높거나 낮은 것은 태아 내의 염색체 이수성의 존재를 지시하되, 임계값 및/또는 기준 분포는 상이한 임신여성으로부터 각각 채취된 다수의 시료로부터, 특히, 제1항목 내지 제12항목 중 한 항목에 기재된 방법의 실행에 의해 결정되고, 상기 방법은 상이한 임신여성에서 채취한 다수의 시료에 대해서 수행되되 별도의 용기에서 그리고 다수 시료들 가각에 대해 유효하게 동시에 수행되며; 선택적으로, 단계 (c) 및 단계 (d), 그리고 선택적 임의 단계 (f)에서 다수의 결정 세트가 각 시료에 대해 수행되되, 특히 제12항목에 기재된 방법의 실행에 의해 수행되되, 선택적으로,
(A) 상기 다수의 시료들의 둘 이상의 그룹이 그룹별로 분석되되, 특히, 각 그룹을 별도의 실행, 분석, 또는 마이크로타이터 플레이트에서 분석되고, 상기 임계값 및/또는 기준 분포는 각 시료들의 그룹으로부터 결정된 양(들) 또는 비율(들)의 정규화에 의해 결정되되, 바람직하게는, 시료 그룹들 간의 상기 정규화는 시료 특이적 양 또는 비율(특히, 시료에 대해 여러 세트 행해진 결정의 평균값) 및 상기 특정 시료가 속한 동일 그룹 내의 모든 시료에 대해 결정된 양 또는 비율의 평균(예를 들어, 중앙값) 간의 차이를 고려하여 수행되고, 그리고/또는
(B) 태아 내의 염색체 이수성의 존재는 해당 태아에 대한 시료 특이적 양 또는 비율에 의해 지시되는데, 여기서, 태아에의 염색체 이수성의 존재는 다음의 (a) 및/또는 (b)에 제시된 위치, 즉, (a) 정배수체인(추정되는) 다수의 다른 태아에 대한 시료 특이적 양 또는 비율이 모여 있는 수치집단의 외부; 및/또는 (b) 염색체 이수성을 갖는 태아들을 나타내는 다수의 다른 시료들 ― 바람직하게, 여기서 상기 태아들을 나타내는 상기 다수의 다른 시료들은 약 2~10, 12~15, 16~25, 26~30, 32~40, 42~50, 52~75, 78~100 , 105-125, 130-150, 155-175, 180-200, 205-250, 255-300, 305-350, 355-400, 405-450, 455-500, 및 500개 초과 중에서 선택된 다른 시료들임 ― 에 대한 시료 특이적 양 또는 비율이 모인 수치집단의 내부에 위치하는 수치집단에 위치하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
15. 임신여성이 수태한 태아의 염색체 이수성을 검출하기 위한 그리고/또는 의학적 증상을 앓거나 발병할 위험의 증가를 감지하기 위한 키트로서, 프라이머 및/또는 프로브의 조합을 포함하는 키트. ― 여기서 이 조합은 둘 이상의 표지처리된 프로브를 포함하며, 선택사항으로서, 각 프로브는 상이한 검출 표지를 갖고, 각 프로브는 상기 둘 이상의 제1 표적 DMR 중 하나를 검출(예를 들어, 실시간 정량화 PCR을 이용하여)하기 위한 것으로 이에 특화된 것임. 이 조합은 또한 아래의 (A) 및/또는 (B) 요소를 더 포함함.
(A):
ㆍ제1항목 내지 제14항목 중 한 항목에 기재된 상기 둘 이상의 제1 표적 DMR 중 하나를 증폭시키기 위한 2쌍 이상의 PCR 프라이머쌍(각 쌍이 하나를 증폭시킴); 및/또는
ㆍ둘 이상의 표지처리된 프로브 ― 선택사항으로서, 각 프로브는 동일한 검출 표지를 갖고, 각 프로브는 상기 둘 이상의 기준 DMR 중 하나를 검출(예를 들어, 실시간 정량화 PCR을 이용하여)하기 위한 것으로 이에 특화된 것임; 및/또는
ㆍ제1항목 내지 제14항목 중 한 항목에 기재된 상기 둘 이상의 기준 DMR 중 하나를 증폭시키기 위한 2쌍 이상의 PCR 프라이머쌍(각 쌍이 하나를 증폭시킴); 및/또는
(B):
ㆍ제3항목 내지 제14항목 중 한 항목에 기재된 상기 적어도 하나의 OR 중 하나를 증폭시키기 위한 적어도 한 쌍의(바람직하게는 두 쌍의) 다른 PCR 프라이머쌍(각 쌍이 하나를 증폭시킴); 및/또는
ㆍ상기 적어도 하나의 OR을 검출하기 위한 제12항에 기재된 적어도 하나의(바람직하게는 2개의) 표지처리된 다른 프로브(각 프로브가 하나를 검출함), 선택사항으로서, 각 프로브는 동일한 검출 표지를 갖고, 각 프로브는 상기 둘 이상의 OR 중 하나를 검출(예를 들어, 실시간 정량화 PCR을 이용하여)하기 위한 것으로 이에 특화된 것임.
또한, 선택적으로, (i) 제1항목 내지 제14항목 중 한 항목의 방법을 실시하기 위한 상기 프라이머 및/또는 프로브의 사용 지침이 포함된 인쇄 매뉴얼 또는 컴퓨터 판독가능 메모리; 및/또는 (ii) 제1항목 내지 제14항목 중 한 항목의 방법을 실시하는 데 유용한 하나 이상의 다른 품목, 구성품, 또는 시약을 추가로 포함하는 키트.
16. 제1항목 내지 제14항목 중 한 항목에 기재된 바와 같이 임신여성에 수태된 태아의 염색체 이수성을 검출하기 위해 임신여성에게서, 모체에서 유래한 상이하게 메틸화된 DNA와 혼합된 태아 및/또는 태아 태반에서 유래한 DNA를 포함하는 시료를 채취하고, 이 시료에 존재하는 DNA를 본 발명 방법에서 일어나는 메틸화된 DNA 및 메틸화되지 않은 DNA를 상이하게 변형시키는 시약으로 처리하는 검출하기 위한 연산을 수행 및/또는 관리하도록 컴퓨팅 시스템을 제어하기 위한 다수의 명령어로 인코딩된 컴퓨터 판독가능 매체를 포함하는 컴퓨터 프로그램 제품. 여기서 상기 연산은
- 제1항 내지 제53항 중 어느 한 항의 단계 (c)에 기재된 것과 같이 상기 시료에 존재하는 염색체 이수성에 관련된 염색체인 제1 표적 DNA종의 양을 각각 나타내는 2개의 신호 (i), 및 제1항 내지 제53항 중 어느 한 항의 단계 (d)에 기재된 것과 같이 상기 시료에 존재하는 하나 이상의 기준 염색체인 기준 DNA 종의 양을 나타내는 하나의 신호 (ii)를 수신하는 단계;
- 수신된 신호 (ii)가 나타내는 기준 염색체의 양에 대한, 수신된 적어도 하나의 신호 (i)이 나타내는 염색체 이수성에 관련된 염색체의 적어도 하나의 상대적 양(들)에 기초하여, 상기 임신여성이 수태한 태아에 염색체 이수성의 존재여부의 유형을 정하는 단계 ― 여기서 적어도 하나는 태아 내의 염색체 이수성의 존재 또는 부존재를 지시함 ― 를 포함함; 그리고 선택사항으로서,
(A) 단계 (c) 및 단계 (d)에서 결정된 상기 DNA의 양을 나타내는 신호들은 상기 시료의 동일 분취량을 사용하여 그리고 동일한 용기에서 생성되고, 또 상기 제1 표적 DMR들 및 상기 기준 DMR들에 대해 유효하게 동시에 생성되며; 선택적으로, (x) 상기 적어도 두 개의 기준 DMR에 대해 동일한 검출 표지(들)를 사용하여서, 그리고 (y) 상기 적어도 두 개의 제1 표적 DMR에 대해 상이한 검출 표지(들)를 사용하여 생성되고, 그리고/또는
(B) 상기 연산은 임계값(들) 및/또는 기준 분포(들)와 비교함으로써 상기 유형을 정하되, 여기서 상기 상대적 양(들) 또는 비율(들) 중 하나 이상이 상기 임계값(들) 및/또는 기준 분포(들)보다 높거나 낮은 것은 태아에 염색체 이수성이 존재하는지를 지시하는데; 바람직하게는 상기 연산은, 상이한 임신여성로부터 각각 채취한 다수의 시료에 관련된 상기 (ⅰ) 및 (ⅱ)의 다수의 신호를 수신함으로써 상기 다수의 시료로부터 상기 임계값(들) 및/또는 기준 분포(들)을 계산하되, 여기서 선택사항으로 상기 다수의 시료는 제1항목 내지 제14항목 중 어느 한 항목의 방법에 의해 하나 이상의 시료 그룹에서 분석되고, 상기 방법은 별도의 용기에서 특정 그룹에 속하는 각 시료에 대해 수행되며, 해당 그룹 내 다수 시료들의 다른 구성 시료와 유효하게 동시에 수행됨; 그리고/또는
(C) 상기 연산은, 추가적으로,
- 제3항목에 기재된 상기 시료 내의 전체 DNA 양을 나타내는 다른 신호 (iii)을 수신하는 단계; 그리고
- 적어도 하나의 수신 신호 (i) 및/또는 (ii)와 함께 상기 수신된 신호 (iii)을 고려하여 시료 내에 존재하는 태아 DNA의 양 ― 특히, 절대적 양 또는 상대적 양 ― 을 결정하는 단계를 더 포함함;
- 그리고 바람직하게, 상기 연산은, 현재의 상기 태아 DNA의 양을 임계값 및/또는 기준 분포와 비교하여 임신여성이 임신관련 의학적 증상을 앓고 있는 또는 발병할 위험이 증가하는지의 유형을 정하는 단계를 추가로 포함함 ― 여기서 상기 임계값 및/또는 기준 분포로부터 상기 태아 DNA의 양이 증가하거나 이탈값을 보이는 것은 임신여성이 상기 임신관련 의학적 증상을 앓고 있는 또는 발병할 위험이 증가하는 것을 지시함
SEQUENCE LISTING <110> LifeCodexx AG <120> Detection of foetal chromosomal aneuploidies using DNA regions that are differentially methylated between the foetus and the pregnant female <130> LIF16458PCT <150> EP15193966.7 <151> 2015-11-10 <160> 246 <170> BiSSAP 1.3 <210> 1 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Primer <400> 1 attgagctgc gggagctggc 20 <210> 2 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Primer <400> 2 tgccgtgtgg ggttgcac 18 <210> 3 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> Probe <400> 3 acccggctgg agcgt 15 <210> 4 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Primer <400> 4 ggtcatccac caccaagaac 20 <210> 5 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Primer <400> 5 tgcccaagga tgctgtcaag 20 <210> 6 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Probe <400> 6 gggcctcaat gacttcacgt 20 <210> 7 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Primer <400> 7 ggtgcgaact cctctttgtc 20 <210> 8 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Primer <400> 8 ttaatcaccc agcgcatggc 20 <210> 9 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Probe <400> 9 ccctcccggt gggtgataaa 20 <210> 10 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Primer <400> 10 tgttcactgg aggactcatc 20 <210> 11 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Primer <400> 11 cagtccatga gggtgtttg 19 <210> 12 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Probe <400> 12 gaggtcccat tctccttt 18 <210> 13 <211> 18151 <212> DNA <213> Homo sapiens <220> <223> RASSF1 <400> 13 gacttggcgt ctgaggacag agtccagacc acaaggatct ggagctcagg agagactcgt 60 gggccacagc ccgagaaagc gctgggaatc caaatactat ggcgattggc agtcgcgtag 120 gcgaggcggg ctagagaccc gcccggattt aggcgcgagc cacctccagg ggcggggccc 180 aggccgcact gcgcaggcgc ggctaacccg tttccatggc tgcgagaact gacgctcccc 240 aaccgtcccg caactgtcct gtcccagact ttggcaccgt cggggtccgt cgtccccgaa 300 tgtgacagca tccccacccc ggctgctgcc caggatccgc cggaccccgg cctcgatatg 360 ggagacctgg aactgctgct gcccggggaa gctgaagtgc tggtgcgggg tctgcgcagc 420 ttcccgctac gcgagatggg ctccgaaggg tgaggcaccc gggtcaggcg gagtcccgga 480 gtcattgtcc ttgagtcggg gagctggggc ctgactcggg ggaggggctg cccagtgtgg 540 aggggctccc aaatggggga gcagagcgtt ccgagacagg agtattactg ctcctgagcc 600 ccctgtgtcc cctcaggatc aggttaggct tcagtaggat ccagccccca tccccactcc 660 taatgcacac acgtggacgc acatgcactt accctctgag gcaggtggaa ccagcagcat 720 gagaacctgg agaagctgaa catgcaagcc atcctcgatg ccacagtcag ccagggcgag 780 cccattcagg agctgctggt cacccatggg aaggtacccc gaggtcacag gcagggttcc 840 tgccttcccc catacctcac ctactctacc cctccggagt cccctgtgtg cccttcccct 900 ctggcctggt acacctgttc tccctgaagg acaaagagga atgtgttaca tgtttcattt 960 tgtatcccta ttggacagga ctctggcaca ccaggctggg tgcagggcat gagttgatta 1020 gggagaaagc tgtaggtcct agaacagctt aggcttcaag gggaaggccc aaatgctaaa 1080 ggcatctgtg aattgactgt aaggctggtg gtggggaagg ggtggggagg ggttggggag 1140 ggcgggaggg aggggagata acctaactgg aggtggaact tcggcatgga aggaagcagc 1200 cttcccaaca tgaaaggggg aagttagaaa ccagggagat gcctggctgg aacatggacc 1260 agggagtgtc accagcagat gacctgagat atcaattgac caaaaaaaaa aaaaaaaaag 1320 ccgggcatgg tagctcatgc ctgttatccc agcattttgg gaggccaaga cgggtggatc 1380 atctgaggtc aggagttcaa ggccagcctg gccaacatgg tgaaacccca cctctactaa 1440 aaatacaaaa atttgcagag catggtggtg cacacctgta atcccagcta ctcgggaggc 1500 tgaggcagga gaatcgcttg aacctgggag gcagaggtta cagagagcca agatcatgcc 1560 actgcactcc agcctgggtg acaagagtga aactccgtct caaaaaaaaa aaaaaaaaaa 1620 agaaaggtcc tttgcaaaag aaagatggaa ctcatactag gggataggat aggaacaggg 1680 cactgtgaag ggtcctgagt aggagtgagg ccaaggcaca caagagcttt ggaggaccac 1740 agacagggac tagagggagg gcatgaggag aagggctggc ttgaaaggga tgcctgaatg 1800 ggcgggcaga ggataagggt gcaggtgcag gcagggcaag gcagtctggg aactgggcag 1860 gagccagtca cataagcatg agggacatcc acagaggtgt tgggagcagc tggtaatgaa 1920 ggtccaaggt gcaagagaga agtcaggaag gatactcatg ggtctggaat agtttagggg 1980 cccagcagtg tttggggata tcagggttga gctgagccgg ggatgggagg gttgccaggc 2040 aaaggtaggc ccatctcatc cctgtccttt accctaccct tcaaaggtcc caacactggt 2100 ggaggagctg atcgcagtgg agatgtggaa gcagaaggtg ttccctgtgt tctgcagggt 2160 ggaggacttc aagccccaga acaccttccc catctacatg gtggtgagct gggcccctgg 2220 ttcatacctc ttctcactcc ttcagagggc tctggaccgg ggaggagagc tggtagcccc 2280 tatcccttcc tcaggccctg tccttctctt tatctgacag gtgcaccacg aggcctccat 2340 catcaacctc ttggagacag tgttcttcca caaggtgagg gactatctct gcccatgggc 2400 cacagttccg ggtcagggcc tggcaggaag ggagattgtg tctgtgtggg gaaggcatca 2460 gacacagaaa gtttccctcc tccttttccc aggaggtgtg tgagtcagca gaagacactg 2520 tcttggactt ggtagactat tgccaccgca aactgaccct gctggtggcc cagagtggct 2580 gtggtggccc ccctgagggg gagggatccc aggacagcaa ccccatgcag gtgggttgag 2640 gttacctagg gttgtgaaag cctaggtctg ggttccccaa ggcctgcgca ggtgagggtg 2700 gcccagcgtg aacactgtgt gacctcccag gagctgcaga agcaggcaga gctgatggaa 2760 tttgagattg cactgaaggc cctctcagta ctacgctaca tcacagactg tgtggacagg 2820 tgagcagtcc gactgggcct gggcctactg tggagggctg gaagaccggg cctgtagcct 2880 gcctctactc acctccttca caacgtccct gcccctagcc tctctctcag caccttgagc 2940 cgtatgctta gcacacacaa cctgccctgc ctcctggtgg aactgctgga gcatagtccc 3000 tggagccggc gggaaggagg tagggtcctc ccccaccagc ctaagcccca ggctactgct 3060 tcagggtatc tttttgatag aggggggcag cttgcacaca cgaagacaaa ccctgtcccc 3120 aagcccactg aggataccag gatgcctcag ccaaggttgg cctagacctg agctctgcag 3180 caggccaggc ccatgtgtcc actactgagg ctcaccctgc tctggggtca gcagccctat 3240 agcctgggca agtcctgcag cccaggttct cccattccca ggcagtggtc agtctcccag 3300 cccccacagc tggctcactt gaagagaatt caacgtctgc acccagtgtg ctggttcctc 3360 tccccaggca agctgcagca gttcgagggc agccgttggc atactgtggc cccctcagag 3420 cagcaaaagc tgagcaagtt ggacgggcaa gtgtggatcg ccctgtacaa cctgctgcta 3480 agccctgagg ctcaggcgcg ctactgcctc acaagttttg ccaagggacg gctactcaag 3540 gtcagactcc ctccgcacca gcccccacag ccccagtacc gccctcccca tcctaccccg 3600 actgcgtccc tgctgtttat ctttgcccac ccacctcaac cccagtgctc ttttcagtcc 3660 ttgggcctca ggtgacacac cagctagtgg gacatgggcc cccacaggca ttctcagccc 3720 aacccagccc cttccttttc cttggccccc tggccagcac ctgcatcaca ctggcctcca 3780 ctggacaccc ttgcagcttc gggccttcct cacagacaca ctgctggacc agctgcccaa 3840 cctggcccac ttgcagagtt tcctggccca tctgacccta actgaaaccc agcctcctaa 3900 gaaggacctg gtgttggaac aggtaggcac tggaaagtta gctgctcagg accactgtcc 3960 cactttacca gcaccttcct gccactctcc acttctctct cctagatccc agaaatctgg 4020 gagcggctgg agcgagaaaa cagaggcaag tggcaggcaa ttgccaagca ccagctccag 4080 catgtgttca gcccctcaga gcaggacctg cggctgcagg cgcgaaggta aggcctgtgg 4140 aaatggcagg gagggtggag gggatgcagg aggcatggat gtgggtgggg tgcccccacc 4200 ttccagggcc agtcagacct tcctgacttt cccccaggtg ggctgagacc tacaggctgg 4260 atgtgctaga ggcagtggct ccagagcggc cccgctgtgc ttactgcagt gcagaggctt 4320 ctaagcgctg ctcacgatgc cagaatgagt ggtattgctg caggtgaggg tatcctagaa 4380 ccttggacct ctaagcccta ctcccacatc ccccacatgc attgccatcc tcaataccca 4440 cctgcctgca gggagtgcca agtcaagcac tgggaaaagc atggaaagac ttgtgtcctg 4500 gcagcccagg gtgacagagc caaatgaggg ctgcagttgc tgagggccga ccacccatgc 4560 caagggaatc cacccagaat gcacccctga acctcaagat cacggtccag cctctgccgg 4620 agccccagtc tccgcagtgg agagcagagc gggcggtaaa gctgctgacc gatctccctc 4680 ctcctcaccc caagtgaagg ctcgagactt cctgccccac ccagtgggta ggccaagtgt 4740 gttgcttcag caaaccggac caggagggcc agggccggat gtggggaccc tcttcctcta 4800 gcacagtaaa gctggcctcc agaaacacgg gtatctccgc gtggtgcttt gcggtcgccg 4860 tcgttgtggc cgtccggggt ggggtgtgag gaggggacga aggagggaag gaagggcaag 4920 gcgggggggg ctctgcgaga gcgcgcccag ccccgccttc gggccccaca gtccctgcac 4980 ccaggtttcc attgcgcggc tctcctcagc tccttcccgc cgcccagtct ggatcctggg 5040 ggaggcgctg aagtcggggc ccgccctgtg gccccgcccg gcccgcgctt gctagcgccc 5100 aaagccagcg aagcacgggc ccaaccgggc catgtcgggg gagcctgagc tcattgagct 5160 gcgggagctg gcacccgctg ggcgcgctgg gaagggccgc acccggctgg agcgtgccaa 5220 cgcgctgcgc atcgcgcggg gcaccgcgtg caaccccaca cggcagctgg tccctggccg 5280 tggccaccgc ttccagcccg cggggcccgc cacgcacacg tggtgcgacc tctgtggcga 5340 cttcatctgg ggcgtcgtgc gcaaaggcct gcagtgcgcg cgtgagtagt ggccccgcgc 5400 gcctacgaga gcggaagggg cagccaaggg gcagcgcagt cgccgcgggt caagtcgcgg 5460 cagagggggt cggcggggac agctcccgag gactaggtcc gttactttcg ccccatcgct 5520 gaagagtgcg cgaaaatggt ttatcccttg tcgcactcca ctcgtatctg ggccacagat 5580 gagcagaggt ggctgcttat atgtaaaaat acgctgattt taagtttctt atctttaaaa 5640 tgccttggcc cttcttgaga aagggtttgt gcctactgtc ctcggagtcc atcttcccag 5700 gcttgcctct tctcaaacac tcatgacccc ctccagaacc tttagggtga agggaaatta 5760 ccacctatgg gagggagcct ggaaaaattt agaacctttg gtgggccccc tgcaagcagg 5820 agttttgttg agtctttatt tagcaaacac ccttttctga cccagtgaat cagatgctaa 5880 aatatgcacg cagccacaca cccagcagtc cttctgcacc cctgggaatc gccagcaagc 5940 aaaggttgct ctcccctggg tagacaccag ctggaatcac caggggtgct tttacagtcc 6000 tccccgctag cctggatccc accgcagacc tgttgaatca actgctggga gtggacccta 6060 ggcatcagta aattttaaaa actccccaaa ttattgtaac atggagtctg ggttgagcat 6120 cactgctctg gcctatttag gaacttgtgg atggatagtg tcccaggtct gtgtgtgcat 6180 ggagaccctc tcatccggta caagaggaca tcacaaattc agctgggggg agcacaaagt 6240 tgtgacagaa tgcaaagaat gaacaagggg ccgagcgcgg tggctcatgc ctgtaatccc 6300 agcacttcgg aaggcggagg cgggtggatc acctgaggtc aggagttcaa gaccagcctg 6360 gccaacatgg tgaaacctca tgtctactaa aaaataaaaa aaaatgagcc aggcgtagtg 6420 gcgggtgcct gtaatcccag ctactcggga ggctgaggtg ggagaattgc ttgaacacag 6480 gaggcggagg ttgcagtgag ccgagatcgt gccactgccc tccagccttg gcgacagagt 6540 gagactctgt ctcaaaaaaa aaaaaaaaaa aaaaaagaac aaggctggga cattgcagcg 6600 ttctcaaaga gaaataaagt agccatggag ataagaagca ggatgatttg ggcatgttta 6660 tcagaggtag agacaaggga gaaatcaaag ataagtttgg gcttttgtct ccagtaactg 6720 ggagcctagt ggccattttt gctgcaaaga ggaagctggg caagtgtagc agtgaggctg 6780 aagaaaaggg aattaaattt tggccatgtt cacttgaaac gtcttttaga catcctagtg 6840 aaggtactgg cacggaggat ctagtctgag ggtttaggtc agtgtttcag ccgtggatct 6900 ggggcagatg aatgtagaca gaccaggcca gtgatcagga ctgagcccag acttcatcgt 6960 gagatatgga agttgagtca gaatctgcaa aggagctgag caggagctgc agggggtagg 7020 aggaaaactg ggagagtgta gcccctggga gtcaaaggga gcaagcttca aatgatgctg 7080 agggggtgag aatggagaat ggaacactgg attccatttg gtagtacaca gatcgctgag 7140 gaccctgtcc cgggcagttt cctggaggaa gaggcaagcc tggctggagt gggtagaggg 7200 gagagtgaag gcgaaggatt agagtgtata gagaccagtg tcttggtctg aggggagtag 7260 agacaggtga caaccacagg gcagacgtag gttaaaggtg tttagttttt ccttcaagta 7320 aatgggcaga tgtattccat atacgttccc agtgaagggc cgggtgcggt ggctcaagcc 7380 tgtagtccca gcactttgga aggccgaggc gggtggatca cctgagatca ggagtttgag 7440 accagcctgg ctaacatggt gaaaccccgt ctctactaaa aatacaaaaa ttagctgggc 7500 atggtggcgg gcgcctgtaa tcctaggtac tcaggaggct gaggcagaag aatcgcttga 7560 acccaggagg cggaggttgc ggtgagccga aatcgcgcca ttgcactcca gcctgggtga 7620 caaaagcaag acgcagtttt ttgttgttgt ttttttaatt gccaatgagg aaaggggaag 7680 ttctgtgcta ggcgatagag atccaactgt tgagcaggcc tctctgcctg tggccttccg 7740 gccggtttcc agacgcccag gtggccaaca ttagagtccg cgtagcagtg tgaggtaacc 7800 cactgagata ggtcgggcct gcggagcctg gcgagcagcg gccctctccc tggggcttcc 7860 cttcaatctc cgggacattt ccccgacctg gagctcctcc gcctcaccgc caggcctctc 7920 tgcagattgc aagttcacct gccactaccg ctgccgcgcg ctcgtctgcc tggactgttg 7980 cgggccccgg gacctgggct gggaacccgc ggtggagcgg gacacgaacg tggtgagcgc 8040 ggggccgagg gcgtatggga agggcgagga tgggcaggcc acagtgcagg cattctcgag 8100 ggctgcctgg gtgccgcgcg caaggagcgt tctaattgcc gatttcccgg cggcacagag 8160 aggctaattc tgcgcggggg ctgggagggg agcctggatt gccggctccg caagtactcc 8220 acccgctgca agcggacccg ggcccaggct gacccaggct ccgcgcacgc gcacttcccg 8280 caccttcccg ccctcgcctc cggccagagg ccactcttgt gcgcttgccc ggacgctggc 8340 acccgccccc gttccctgtg gtaggtgggg tctgtgagtg gagctccgga gcgatgaggt 8400 cattcctggg ggcgaagcgt gcgtgtcccc gccccggcgt tcctgcccca atgagacaag 8460 agctagatcc cggcgatcta cgtttcagtc ttaacggttg cggcgcggct ctggcccggg 8520 cgcacgcgca cactgacacg cgtacacgca cgcacgcgac cggggcggtg gttggcggct 8580 acggacgcgc aggactgggg gacgggcggg tacggctatg ggcgaggcgg aggcgccttc 8640 tttcgaaatg acctggagca gcacgacgag cagtggctac tgcagccaag aggactcgga 8700 ctcggagctc gagcagtact tcaccgcgcg aacctcgcta gctcgcaggc cgcgccggga 8760 ccaggtggga gccagggggt gccggcgggc gggaggggaa gcggtcgctg gagctccgcc 8820 ctccccggtc cgttgccgcg tcctgggtcg gtgggcagcc ccaccctcct ggctacgtgg 8880 ctccccgcgg gtcctggccg gggacctgcc cgcggaaccg tgcgtaagac cccgattcca 8940 ccgcctagat gctgggtgcc ggggccccct tggtttctgt cacagacagg ttgaacacgg 9000 aaaaagcagc tgtatggctt gtggtagacc tgagccgggc attatccagc tatgactaaa 9060 gccgaccgag cagtttggac tagcacctcg atttccgcgt tcgaatgctc ctgctccctc 9120 cttggggaga ctaggggagg atgtggagag ggaagagtcc tcgccaggaa ttgagaagta 9180 tgtttaggaa aacttgagag gcagagagag atcctgctcc tccatctgca ctcctgtatg 9240 gagccagctg agccctcacc tcttccctgt tctggcctgt caccagctgc tggaatgtgg 9300 aagattctgt tcccttcctc tagggtggat ctggagaaag atttgggaat agataggaaa 9360 gaagtcttgt tttggaccat aagcattcag gagcacttta cccacaggaa gggggaaagc 9420 tagattataa aatgcctaaa gaggtggaaa aagagatcca ggttactaac ccaggactgt 9480 aaggtgtctc ggaacctcct aggtatcccc attatcggag aactgtgtgc cagatgccat 9540 tggtgtgacc accaggctca gagaaccagg cctaggcacc aggaaaaaga aacagggact 9600 gtgaagctca gtatgcctgg cagaaatggg gcggaaatcc ttatttaagt aaagaaagtg 9660 gagttgtgag tgatgcttca gataaaattt tacaaaattc cttacaaaat gggtggtgct 9720 cagcacgcca aaatcttagc ccagagcttg ggtgcaaggg ttgagttgag tgtagacccc 9780 tgggcttgtc ttcatgtcag tcagtcctga gccattttcc actgtggaaa ggtgggaaaa 9840 ccacaagaca ctaaccaatt gaaaaggagg gctagccacg gaggtgcaca cctgtaatcc 9900 cagctacttg ggagggtgag gcagaaggat cacttgaacc tgggaggcag aggttgcagt 9960 gagccaagat cgtgccactg cactccagcc tgagtgacag agtgagactc tgtctcaaaa 10020 atagaaaagg aagccaagta cggtggctca cacctctaat gccaatgctt tgggaggcca 10080 aggcaggtgg atcatttgca atcaggaatt cgaggtcagc ctggccaaca tggtgaaacc 10140 ctatctctac taaacataca aaaattagcc gggcatggtg gtgtgtgact gtagtcccag 10200 ctacttggga gactgaatca cttcaaccgg gaggcaaagg ttgcagtgag ccaagatcgt 10260 gccactgcac tccaacctgg gtgacagggt gaggctctgt ctcaaaaaaa agaaagaagg 10320 ctgggcttgg tgactcatgc ctgtaatctc agcattttgg gaggccaagg caggcagatc 10380 acttgaggcc aagagttcga gacctgccag gccaacatag caaaaccccg tctgtactga 10440 aaatacaaaa aaattatctg gccatggtgg tgtgtgcctg taatcccagc tactggggag 10500 gctgaggcag gagtatcact tgaacccaga agacagaggt tgcagtgagt cgagactggg 10560 ccactgcatt ccagcctgga tgagagagca agactctgtc tcaaaaaaaa aaaaaaaaaa 10620 aaagaaagaa taggaggctg agaagtccca agttatatgt taaaaaaaaa gaaaaaaaca 10680 tcagttttag gccaggtgca gtggctcaca cctttaatcc cagcactttg gaaagccgag 10740 gtgggtggat catgaggtca ggagttcaag accagcctgg ccaaaatggt gaaaccccgt 10800 ctcgactaaa aatacaaaaa attagccagt tgtggtggca ggcacctgta atcccagcta 10860 cttgggaggc tgaagcagag aattgcttga acccaggagg cagagattgc aatgagccaa 10920 gatcgcacca ctgcactcca gcctggaaaa cagagcgaga ctctgtctca aaaaaaaaac 10980 catcagtttt tatggacagt ggtagagtgg agggtgggtc cctatggtgc agaagggaaa 11040 ttccatggtc ctgctgtgca tccgactggg atggctgttg aaatcctctt ccagcaggca 11100 gctttggaaa cagaaaaaga aactcttcct cctttagaat cctggaaggg ctgtgcagtg 11160 cctctaatcc aagtctgttt tctgagtgaa gatagggagg ttcatcacca gaagggaagg 11220 ggctggaaat gaggtcactg catcccagcc cagggctcct gggtcatcca ggaagggaag 11280 aaggagcaag ctttctcatt gttaggtagg agctcagagc catcacaaga acaagttagc 11340 accatccctg tgccctccct gttctgcaaa caaaatgatc ttccttcttg ccctggcact 11400 agagtctgtc tggcatttct cctgccccta gtactcctcc catctgggta cttcttcccg 11460 ttggtgtact gaacaaacac atccactgct ttattcacag cctccagccc tcattttcca 11520 gggcccacac catttgtttt tactaacccg acaaggttgc ccactgtccc cagtaaggtt 11580 tgtactgggg tttttactcc agtgctcttc tccatccagg agacctttgg atacttgggg 11640 aagaaaatga gcttaaattc ccacccctcc ccctttacct ttttcctgta aggccctggc 11700 cttagttctt agccccacat ccttgctggc tgcagaatag cagcgggttc tgggtaagga 11760 gcattctgct aaaacgctcc accctgctcc ctcatctgtc ctctccattt gtccccatca 11820 gatggtttaa gtgcttaagg ggactccagg gcggagtcag ggagaaccct ggctctcctg 11880 ggctaggcac aagatcattc tacaggaaac cttgtgggaa ttcttctggg acaaagtatt 11940 ggtcagcgct gagcttagct gtgtctgtga cactcgcatt ctaactaggg cctatctgac 12000 gtcaacagga agtaaggctg atgcagtggg gccaagggag tctgggagaa gaaagtcggt 12060 tcagagccct ggctgccctg tcccacactc cacccttccg gcaagaatcc agtccctaga 12120 tgaggtgggg agtgagtggt cgagttaaaa atctctgggt cgggtacgat ggttcacgcc 12180 tgtaatccca gcactttggg aggtgaaggc aggcggatca cttgaggtca ggagttcaag 12240 accaacctgg ccaatgtggt gaaatcccat ctctactaaa aatacaaaaa ttagccgggt 12300 gttgttgtgg cacgcgcctg tagtcccagc tactcgggag tctgaggcag gagaatcgct 12360 tgaacccagg aggcagaact tgcagtgagc caagatccag ccactgcact acagcctggg 12420 cgacagagtg aggcttcgtc tcaaaaaaaa aaaaaatctt tgggccaaat ctccagacag 12480 cacaggcagg tgcagaaacc caccaggaag ctgcctgtgt acctctggca gattggagcc 12540 tggcctaaag ctgcctttta tgcagcttgg gtcaaggtta aacatcatgt cacagtgatt 12600 tttctcacta tgtgtgagac atggagaact ggctccaagt actactctgt ccactggtgg 12660 ctggactact gatgtgcacc actctccact cctctcaccc tgcagtgggt catggccccg 12720 tgccggggca gaggagaaaa atgggctgcc ttctccagga caaaccctca ctccaactca 12780 actagggtgc tgtgatcaga atgtgcaatt gaggtgtgat tttactgatt tttttttttt 12840 ttgagaccga gtttcgctct tgttgcccag gctggagtgc gatggcacga tctcagttca 12900 ctgcaacctc cacctcccga gtttgagcaa ttctcctgcc tcagcctcct aagtagctgg 12960 gattacaggc atgtgccacc acgcctggct aattttgtat ttttagtaga gacggggttt 13020 ctccatgttg gtcaggctgg tctcaaactc ctgacctcag gtgatccacc cgcctcggcc 13080 tcccaaagtg ctagaattac aggcgtgagc caacgtgccc agcctgtttt tgttttttgt 13140 gttttgaagc agggtctcac tcagttcccc aggctggagt gcagtgacac gataatagct 13200 tactgtagct gcaatctccc gggctcaaac gatcctccca cctcagcctc ctgaacagtt 13260 gggactacag gcacaccacc acacctggct aatttttttt tttctttttt tagtagagat 13320 gaggtcttgc tatgttgccc aagctggtct caaactcctg aggatcaagt gatcctccta 13380 ccttagcctc ccaaaatgct gggattgcag atgtgagcca ccacacccag cctgatttta 13440 ctttaaatga gagtccctct tcagagtccc tcagctgttc ctggcccctg gccatgtgcc 13500 ttcagttgcc cctgcttctg tggtatcctt aaggctacat tcagtgctga ggccctaggc 13560 aggcagcaga gagaagccaa atgattctgt ctttccctta tccacccaga gcatgcaaaa 13620 ccaggagcag tggtgggttc agggtgggca ccagctatgt atatgtacat cagggacagg 13680 gggccaaagg cagtcagttt ccaaagactg ccccagaggc catttttcag agaagccctg 13740 ggttcctcaa gggccctgtg tccatgctgg cccatcttgc aggacgagcc tgtggagtgg 13800 gagacacctg acctttctca agctgagatt gagcagaaga tcaaggagta caatgcccag 13860 atcaacagca acctcttcat gagcttggtg agttgactgc tcaggaaggg ggcgtgggga 13920 ggagcaggta cccagctatg tgcctgatac tcagagggtc acaactgagg ttatcttggg 13980 tgggcgcaag cagtaatttg tgcataccca gcctagcccc aagtagactg acatctcacc 14040 tggaacctat tatcaaggtt tggtttctct atttctttag aacaaggacg gttcttacac 14100 aggcttcatc aaggttcagc tgaagctggt gcgccctgtc tctgtgccct ccagcaagaa 14160 gccaccctcc ttgcaggatg cccggcgggg cccaggacgg ggcacaagtg tcaggcgccg 14220 cacttccttt tacctgccca aggatgctgt caagcacctg catgtgctgt cacgcacaag 14280 ggcacgtgaa gtcattgagg ccctgctgcg aaagttcttg gtggtggatg acccccgcaa 14340 gtttgcactc tttgagcgcg ctgagcgtca cggccaaggt gggcttccca ccccaccctg 14400 ccctatgtga gggtatatac gcatgcacct gagcatgcag gggctgagca gctggccctg 14460 tctctgatca ttacttcccc ttcacagtgt acttgcggaa gctgttggat gatgagcagc 14520 ccctgcggct gcggctcctg gcagggccca gtgacaaggc cctgagcttt gtcctgaagg 14580 aaaatgactc tggggaggtg aacgtgagta catagttctt agtttcttgg ttgtcactag 14640 acaggactga tgggctgtag ctacagtaag gcttggagga ggaattgtgc tggaagacaa 14700 gccctgcaaa acagttccag gagtgtatag gcattgtaac taaagcaaag gcttccagac 14760 cactcatgcc aaagcctagg gttgtcccaa gaagccagga agaattgcct tggtgctttg 14820 atctttcctg gtgtggaaaa tcttctggag atgcaggagt ccatctaatg acatgaggag 14880 gcccccttca gactttttac ctggaagctt tctggctcca aggtattagg cctgtggagt 14940 gaaattagac tcagaatatg cctgacctgt ccacaggtaa ttggggaaca tctgacttgg 15000 ttgtctcagt aaggtgaccg ttttgtaggg cccatcttcc atacaaactg ctgtcaggga 15060 tcctaccaga gatcattcag ccaagagcct gacatcagaa agcccagtcc tagcttgtgt 15120 gaacatgagg tgctagtctt ctctggggag ggtctgctgg cttggccatc ccttctgcag 15180 cctgtacact ccccttttgc cccttgcagt gggacgcctt cagcatgcct gaactacata 15240 acttcctacg tatcctgcag cgggaggagg aggagcacct ccgccagatc ctgcagaagt 15300 actcctattg ccgccagaag atccaagagg ccctgcacgc ctgccccctt gggtgacctc 15360 ttgtaccccc aggtggaagg cagacagcag gcagcgccaa gtgcgtgccg tgtgagtgtg 15420 acagggccag tggggcctgt ggaatgagtg tgcatggagg ccctcctgtg ctgggggaat 15480 gagcccagag aacagcgaag tagcttgctc cctgtgtcca cctgtgggtg tagccaggta 15540 tggctctgca cccctctgcc ctcattactg ggccttagtg ggccagggct gccctgagaa 15600 gctgctccag gcctgcagca ggagtggtgc agacagaagt ctcctcaatt tttgtctcag 15660 aagtgaaaat cttggagacc ctgcaaacag aacagggtca tgtttgcagg ggtgacggcc 15720 ctcatctatg aggaaaggtt ttggatcttg aatgtggtct caggatatcc ttatcagagc 15780 taagggtggg tgctcagaat aaggcaggca ttgaggaaga gtcttggttt ctctctacag 15840 tgccaactcc tcacacaccc tgaggtcagg gagtgctggc tcacagtaca gcatgtgcct 15900 taatgcttca tatgaggagg atgtccctgg gccagggtct gtgtgaatgt gggcactggc 15960 ccaggttcat accttatttg ctaatcaaag ccagggtctc tccctcaggt gttttttatg 16020 aagtgcgtga atgtatgtaa tgtgtggtgg cctcagctga atgcctcctg tggggaaagg 16080 ggttggggtg acagtcatca tcagggcctg gggcctgaga gaattggctc aataaagatt 16140 tcaagatcct cctgctgttg gaatctttta tacatataaa gtttttgtag agacatgagt 16200 ctctctgtgt tgcccaggat cctcccaact tggcctccca aagtgttggg attacaggtg 16260 tgagccaccc tgcccagcct ggactcttta ttattatagg cgcagagctg cagttgcccc 16320 tcatggtgcc agaagttgcc aagggtgatg gacaggctcc caggtgtctt gcaaagtcac 16380 catggaccaa tttgtgaaga tgtagtatgc atacatactt ggtcatcact cagctccctg 16440 gggctcaggt tgtggtggag acaaaaatgg actgcagtta gaacttaggg aaactggctg 16500 ggcatagtgg ctcacacctg taatcccaac actttggttg ggctaggtgg gcagatcact 16560 tgaggccagg agttcgaggc cagcctggcc agcatggcga aaccccatct ctaccaaaaa 16620 tacaaaaaaa atttagctgg gcgtggtggt gggcgcttgt agtcccagct actcagaagg 16680 ctgaggcagg agaatcgctt gaacccggca ggcagaggtt gcagtgagtg gagatcacac 16740 cactgcactc cgatagagca agactccaac tcaaaaaaaa aaaaaacggc cgggcgcagt 16800 ggctcaggcc tgtaatccca gcactttggg aggccaaggc gggtggatca cctgaggtcc 16860 ggagttcaag actgcctgac caacatggtg aaaccccgtc tctactagaa atacaaaaaa 16920 attagccggc atggtggcag atgcctgtaa tcccaagtac tcgggaggct gaggcaggag 16980 aatcgcttga accctggagg cagaggctgc agtgagccga gatcgtgcca ctgcacatta 17040 tcctgggcga caagagtgaa actccatctc aaaaaaaaaa aaaaacaaaa ccatcccttc 17100 aacacacaca caccacgctc tgggagaagg tgtggcataa ctccttcacc aaatacagag 17160 ctgccaccgt ggaccagaca ctgctcgtga taccgagggt atagctgtta acaattcttg 17220 ctttcattaa gcatggactc tgctgggttt gaaaacactg aattcgaagt tcttcagaac 17280 tgaatgtaac tatgtgaatc tggccagttc cttaattttc tttcaacttg gttagttcac 17340 ataagcgtgg caatcgcaaa aatacagctg tgaaaataga agccagatgg gcacccggcg 17400 gtctggcctt aggccctgaa gtgcaggttt gaggattggt gcttgcgaag tcctgctagg 17460 cctgaactca ggtgttgggg gacgtcagag ccgccaaata cacccaaaag accgggagga 17520 ctcacggcca ccactttcct cggtgggagc tgtcccagct ggtcagatcg cgcttgctgg 17580 gacctgggat ctcgcaacgc atgctgggat gcccagcatc taagggcgcc cattggtccc 17640 gcccccacga cttgagcaac agccaatcag aggtggcagc gtgcggaagc ggaagtgagg 17700 tttccgtgga gacagccgag cctgcggaag gcggcggcgg cggcacctgc gatcagcggc 17760 tggggcaggt tatggtagtg cggactgcgg tgtgagcaga gcggccacgg ggcccgccat 17820 gcgccggcgg ccctgacatg ggcgccagcg ggtccaaagc tcggggcctg tggcccttcg 17880 cctcggcggc cggaggcggc ggctcagagg cagcaggagc tgagcaagct ttggtgcggc 17940 ctcggggccg agctgtgccc cccttcgtat tcacgcgccg cgggtaaggg catgggttcc 18000 accctggcgg ggggaacagg cgggcggcca ggcgtcccgc gccacggggg aacttccacc 18060 gctgtacccc actacagcca agccaggacg acccccatat tttgagcctc attggagctg 18120 ggggtggaga aagccgggca gtggtctcct g 18151 <210> 14 <211> 20911 <212> DNA <213> Homo sapiens <220> <223> TBX3 <400> 14 agggatctcc aggctgtcat ggttgctggg aaagatgagg gagggaaagg gggcagagta 60 cggaggcacc aggtcagaaa gacaggagag aattcagaca ggaccaaaac agccagaaaa 120 aataggataa agaaggtaga aaaaaaaaaa aaacaaaaca aaacatgaga agttaaagcc 180 tgggaaatag atacaagaca agaaagagaa atagaaacca agaacaagat tgatgaaagg 240 aggagaagag aaagtagaag gaaaaagaat aagaaagatt ccagacacgc attcaaataa 300 tcctaaatgg ggatgagcag aaagacaagg agaccaaaag aaaagggggg gggggggtgg 360 tggggaggag aaagaaagga atggaaaaag aaacaaaagg tgaatgtcct gccctgtctg 420 tctggtccaa ccaagaagct agtgtctgcc ctggagggag gaaaggtggg ggagtccagc 480 ctgtctccaa gggactgaca ggcagcttct ggaccagaga ggaactaagc tctcaaagca 540 agctttgggg aggaggaagg gatgggggtg catggtgagt ggagactcct ggaggaagag 600 caagcctcca ctgggttcag cactgccagg gggagagtca gggttcaggg tagcatagca 660 gtgctaatgt atgtacccca gaggggtagg gggtgctagg gcaatttgca ggaggaccac 720 aaacagtaaa ctagagagct acttccctgg gatccgtgat aagaaaatca cttcctcagg 780 tgggagaatt gagcccgaaa gagaatggga gcccttgggg ggcaggcacc tggtcagttt 840 caaagctcgt caatatcaaa agaggctggg atcctgagat caaatgggct ggggcactgg 900 gcagaaacga ggagccattg ccaaactgcc aggatgacca gaacgcccct cccccaggaa 960 aagttcatat atgaacccac ccctgtatga aacttcttaa ttaggtctca tacccccggt 1020 gaatcttgga tgcccttctg tcaacagaat tcccaattta gtgacacctc ggactgaaaa 1080 gagctctgcg gcaaacgggg gtgaaagttt aagagggaat aagcatataa tactcccttg 1140 ccagacctca cacatgctga agggaatatt tacagcaaac tggccaaagc aaacgacccc 1200 gcctacccac catcctttta ccctcctccc cgcccttttt gtaaactcca gataaacacc 1260 atttgatcac aaaagggtcg gtttgtcccc tttatagttt gaggcaggca gtgcggcagg 1320 gaaaagtggc gtgggctaag cttccgtctc gggcaaggcc agcttctttg ctggcaccgt 1380 ggcctgggct aaggacagtt gatttggttt tgtttccccc gacccccacc ccgaccccac 1440 ccccacaaag gaacattatt ttcagggtcc tccccccacc cagctttaac actcgcctac 1500 ttgcacccgc actactttaa atgctgcggg cattgcagat agagaggttt ttcagttaat 1560 ttactttttt aattctagag ctacaattaa gtgaaaactc tttttgcgaa aaggtggagg 1620 aatatttcag agacgccaga aattatctgg gtcttttctg acccggaatc tgccctcttt 1680 ctcccttctc ctccccttaa gtcacccttt tctgggactc tgttgaaggg caggctcttt 1740 caacgtctct agtctgtctt ttgttgagtg tgagaccgaa ggaaagagga tcgaggggtc 1800 tgcagagaga aaaagaccgc agatagccgg cagctggcgc ctaatgccgg ggtccgggga 1860 gcgctggcct cgtgggttct cctggaggcc aggcccagca caagccttcg gaacacgctg 1920 gccaatgttt aacccgaatg cagtggccac caggccgctt ttgtttgttc gcaaattaat 1980 cacccagcgc atggccggcg ccagagtggg tttatcaccc accgggaggg gggcgcgccg 2040 ggcacgcaga gacaaagagg agttcgcacc ttcccgcttt tgatcccaga attacggcgg 2100 cctccctgcc taatacgagc ctcctggggc cgagtctggg aggtcagtca taattggcgg 2160 aagtttgcag accattagca agatgtcgac attttcgatt cgaaccccgc aaactttcct 2220 ctcgttctct gcttcgcgcg ctggaggttg gtgtgggaga ggagatgggg gtcagaagta 2280 gcgatctggg gtgatcacag ggttaagtta gagctatggg caaaaaatag gcaattgagg 2340 gaggaggaca gtgtgagggg cagaactccc tctcagtcca cccgcggagc caaaaacaaa 2400 tctagacatt tttaagtaaa atccgcaagc tcccctccca tttccaaagc tgacagctgg 2460 ccagaatgca gaggaatgtc tctctgctgt gcgtgggacg cttgggggca ccgagtgggt 2520 gaggaggagg tcggtcacag tgtggttgta gaactacttt gcttccaccc caagtagtgg 2580 ggcagagatt ggcctgcgag ggcaggcagg caaaaccaga tcgctgggat ttggggccgc 2640 tcttgaaaga gcagcgaagg ggccccaggc cccggaggcg agcagtctgg gggagggggt 2700 gcactttttt tttctatttc tttcttttct tttctttttc ttttttttgg ggcgggggtc 2760 cccagagact catgaaaccc tgcagtgact tccgtgttct gtgtaaggcg ggaaatggcc 2820 tggcctttcg cacccttcag gtggggagga ggggatgcgg gagggggtgt tatgagccaa 2880 cactctgggg caccaccacc tcgtaatttt ccctctctct cctttctcta ttttaaccac 2940 tggcagagac agagaggacg ccagagaaag acagactgaa agggaaagaa aggggcgaga 3000 tggcgagcca gacggagttc gcagaaccac actattctct ctggtgactt cagggaattc 3060 tcaacgctgg cgccaagctc tcttaaccat gtgcgtcaaa aatgcgaggc tggagaagcc 3120 tgtcgcctca aaagatcctc ccctatctca gcgtggttgg cccacaagag cacttcattt 3180 tcacccttcc cttggtgcca cgttggggtt tcggggttgc tgggggttgc gcgggtgcac 3240 aaggcaaaat gcgagagagg cctgtgctgg cctacagaga cacacacatc caaagccctg 3300 agtctcttaa acccctaagc ccccagatca gccctttctc cgttcccttt ccatcgaaga 3360 agctttcatc tcaggaaaga taaaagaaca ttgttttcaa gatttccctc catctaagca 3420 aggatggtcc aagacattgg cccccagaat caagaactgt gggcttaggc gaatcctctg 3480 accccgaccg ggcgctgcgg taacagagtt ggtaattcgg cgattggtaa gatccggtcg 3540 tttccctccc gtccgcctaa gaggaggccc ccaccctacc cgtactaaaa acagtcaact 3600 cgcctctgag gtgggggcgt ttcacggttt gttttacaaa ttcaccctcc ctccccgact 3660 tctggccaga ttaagtcccc ggggtggaga aagaactgag gcaccgagag ataagtgcga 3720 tgcctagaga agataccagg ctggcgcgcc tcccccaacc caatcgccca ccccttaccc 3780 tgtgctgtgc acccagccgg gcctcgaggt gagggcagcg gcttggaggg gacaggctca 3840 gaacccagtc tctcgctgtg ctcgctttgt ccagatcctc cattctcttc tctacaccca 3900 cacccacatc caggtggaat atgggggccc gcatgcaaat gaaagacgag atccaaaagg 3960 gctggtaaat gcatttcata aaaatcccaa atccatcttc cccaggagct caggcagggc 4020 cagccgcgca ggctgtgtac gtgtttgtgt gtacgtgttt ttcggtgtgt gtttcagtcc 4080 cagtgtgttg gcgcgtgttc gagtacagat acaccggggg tgtttgggta cccgcacatg 4140 gctgcgggtg gggcgcagtg gagaggaagc ccacacatgc gtgtgctgag atatggccgc 4200 atccttgtgc tcccccagcc cagacgcagg ggagaccagc accgagacac ccgagctcgg 4260 gagcccttca gcggcggccg ggcggagctt ggctccacgt ggggctggag agcacgcaag 4320 cctggagtct cggcgctcgc ttctcggctg ccgccggctt ttgtagaacc gagtggccgg 4380 atggcagctc gcggggaggc tcggccaccc gcccggctcg cccggggcgg ggagaagaag 4440 gagagctgga gagagaaccg gccgcggcgg tcggagaggc gagcggagtg caagagaggc 4500 gagcgcccct gcccggcgcc cgggcgcgct ctccgccttc cccgcccggc tcgcctgctc 4560 gctggctccc tccctctctc cctccccctt cctccttggc cctgcctcct ccctcgatcc 4620 ccggctggat gactgaggca tttcagacgt gggctgaacc agagcgagcg agcgagctca 4680 ggggctgcag cgatctctcg ataagccacc tagaggcgac tctgtgcgcg cgcgctcccc 4740 agtggctccc gcccgccctc tgatcatgtt gacatattca caggacaggc agtagtaccg 4800 atgcggcgct gcgacgttac agtttccgac accttctttt tataactcag ctctatcccc 4860 cagcactcga cctgtgaaaa ccacgcctat gcagcaacac aattggtccg aaagcgtcaa 4920 agagccaatc aagaggcctc cggctccccg cagcccacag cgcagcccga ccttctagag 4980 ccgccgagca gacgcccggt gaattctaga ggcggcggag ggtggcgagg agctctcgct 5040 ttctctcgct ccctccctct ccgactccgt ctctctctct ctctctctct ctcccctccc 5100 tctctttccc tctgttccat tttttccccc tctaaatcct ccctgccctg cgcgcctgga 5160 cacagattta ggaagcgaat tcgctcacgt tttaggacaa ggaagagaga gaggcacggg 5220 agaagagccc agcaagattt ggattgaaac cgagacaccc tccggaggct cggagcagag 5280 gaaggaggag gagggcggcg aacggaagcc agtttgcaat tcaagttttg atagcgctgg 5340 tagaaggggg tttaaatcag attttttttt ttttaaagga gagagacttt ttccgctctc 5400 tcgctccctg ttaaagccgg gtctagcaca gctgcagacg ccaccagcga gaaagaggga 5460 gaggaagaca gatagggggc gggggaagaa gaaaaagaaa ggtaaaaagt cttctaggag 5520 aacctttcac atttgcaaca aaagacctag gggctggaga gagattcctg ggacgcaggg 5580 ctggagtgtc tatttcgagc tcagcggcag ggctcgggcg cgagtcgaga ccctgctcgc 5640 tcctctcgct tctgaaaccg acgttcagga gcggcttttt aaaaacgcaa ggcacaagga 5700 cggtcacccg cgcgactatg tttgctgatt tttcgccttg ccctctttaa aagcggcctc 5760 ccattctcca aaagacactt cccctcctcc ctttgaagtg cattagttgt gatttctgcc 5820 tccttttctt ttttctttct tttttgtttt gctttttccc cccttttgaa ttatgtgctg 5880 ctgttaaaca acaacaaaaa aacaacaaaa cacagcagct gcggacttgt ccccggctgg 5940 agcccagcgc cccgcctgga gtggatgagc ctctccatga gagatccggt cattcctggg 6000 acaagcatgg cctaccatcc gttcctacct caccgggcgc cggacttcgc catgagcgcg 6060 gtgctgggtc accagccgcc gttcttcccc gcgctgacgc tgcctcccaa cggcgcggcg 6120 gcgctctcgc tgccgggcgc cctggccaag ccgatcatgg atcaattggt gggggcggcc 6180 gagaccggca tcccgttctc ctccctgggg ccccaggcgc atctgaggcc tttgaagacc 6240 atggagcccg aagaagaggt ggaggacgac cccaaggtgc acctggaggc taaagaactt 6300 tgggatcagt ttcacaagcg gggcaccgag atggtcatta ccaagtcggg aaggtaagca 6360 gtgggggcct cctcccctaa gctgttggag agttttttcc tccctttatt tctctgctcc 6420 cagaacagtc ggttggtcgg ttattacggc ttggacgaaa agttagttcc cctagaaatg 6480 tatgcacaga cttccaggcc ctgccccggt ggcaggaaat ttcagcttac ctgggcatct 6540 gcatgggtct tgcatttggt ctgcatcctg ggttccctcc cgaacagaca gaatttttca 6600 gtggagcaca gacatccctg cagggagcag gaaagaaaaa aaaaaaaggc actctactgc 6660 aagaaactca ctcttcaaac cctcctggaa catccttatt tctttgttga tgttgtgttg 6720 tctgttttat tttgttctca gagagaaaaa cttaaagccc tttccttttg tgtgggtatt 6780 gggaggcctg acaccattcc ccggcccttt ctgccctcca gtctagcctc tgggtctaaa 6840 ggggcctgct gctgccctgg tcagagagaa atcgaagggc attttggttt gtttgcccac 6900 actacttcac gtgtctgtaa cccaagggcg agttcagcag gcaattttgc ataatttaag 6960 attatgtttg cagacttaag gagccagtga ggagacacac accttttttt taatgtgtga 7020 atattatcaa ccatatttta cataatgttt aaaggtcctt gcctgaccaa aacctgcctg 7080 gaagagaaga tcctgtaata gtcatttaaa atcactgatt ttttttttgt aatagcattg 7140 aagcctgtaa aggcataaag ttgatacaaa aataaaatcc ccttcatgat atcttaagcg 7200 ttctgtctcc ttccaagcta aatgaggcca aagtttggca taaaatcctc ctcaaactca 7260 caagacattt agtcagtttt ccagcaaagt gcttccttgc ttccttttaa gtcaagacta 7320 cagaatgcca acccttctgt gaaattaaca gcaatgtggt ggcacagtct tgcggttttg 7380 gactggccta agaagtgggg gaatgtgtta gcagctccac gggcagatcg gttatcaggc 7440 ccaggagtgc accgaagtct gcaaaattcg ttctgggaac tcactgaagt ccagtttcac 7500 ttcgcccaca gcgggattgc tattctgcag cagggagggg tgcaacttga cgttcatttc 7560 cttgataagt ttaacatttt ctcatcaatg ggtggtggaa aattctagtc ttaactgacc 7620 gcgctttaca aaaatcttac cccaacctgt ttagatctag atacccacag aaaaagacat 7680 gggcaagaat ttgctctcag gagggcaatc tgtaaagtca agcaaggaca aaaaaaatat 7740 tgaagaaatt gttagacaat gtagagaatt gcagtgccac aatgcatttg ttttgaacct 7800 tgggacgtct aaatatggcg aaactgagaa tatttaatac gttagttgtg gaagaaaacg 7860 attttgcaac cagttgcctc actctgaaac atgtaagctt atcagtcaca atataaagtc 7920 ttagacttgg tttcaatatt atgtgataca taggaaatca aacccaagat tacgggtggt 7980 ttatctttct ttttcttttc tattctttcg ttttataggc gaatgtttcc tccatttaaa 8040 gtgagatgtt ctgggctgga taaaaaagcc aaatacattt tattgatgga cattatagct 8100 gctgatgact gtcgttataa atttcacaat tctcggtgga tggtggctgg taaggccgac 8160 cccgaaatgc caaagaggat gtacattcac ccggacagcc ccgctactgg ggaacagtgg 8220 atgtccaaag tcgtcacttt ccacaaactg aaactcacca acaacatttc agacaaacat 8280 ggatttgtaa gtttcattgc tctcttcagt aaaattttct cctccttcac tcagtcaaag 8340 gcagtgcttc ccatttcatg agtttcagcc cagacttctc ctttgcttct ccctaagcat 8400 agcaaacttg tcctcgtctg gaaaaaggat tcggggtgtt tctctccaaa taatggaagg 8460 cctggcgttc taaaagaaat ggggcaagaa aacttaccgg cttgtgttct atagcaattc 8520 cagctctttg gtagattcct gacctgagag tgaagttaaa aaccattttt taagagctaa 8580 aatcaatttc aaggctatgt attcctaaag gatttgtttt gttttaaaat atcatacttc 8640 tgttttgaaa ccagtgatat tattttctca ggagagttta cgtttcggag ccttgactct 8700 gttggttaaa tggtgtgaat acatttttaa aaactcgttc ttttactaaa aaaagaattg 8760 ggcttaggtg ggagtccggc ttaccctaaa tgaggcttag atcttcagaa aaaaatggtt 8820 tgtgtgttgg gagtgtatat atggattcag tgacagtgct tagaaactta gaaaactttc 8880 attgcttgta gatatcaggc aaaggacctt ttgcgccttt tcctacccct ccccaacatt 8940 tcaataaaat aaacagcgtg ataagcaagg agtaagcaga aagattaggc ccaggaagac 9000 gcgaatggcg cggaaatatc ttcagcgggc aggaattgca tttgaagccc ttgatttgat 9060 taaggcataa atattcctct ctagagttca gcctttcagg gctttaagtg gattgggctc 9120 gtcaattagt gggcgcttaa agtactgaat cattttgtaa attaaaatgc atgtttttct 9180 ctatctttta agactttggc cttcccaagt gatcacgcta cgtggcaggg gaattatagt 9240 tttggtactc aggtaggcta gggttcaagg tatgaatgat ccttagatgg tgagggtggg 9300 gggggccctt tggcaactga ggagcaattt ggattctcca gaagataaca tctgtggagc 9360 gaaacgtacc cagggggtac tccaaggagg tgggctcggt acaagcgtgg taccctgcgg 9420 tggggaagat ttcagcctgg caggggtcct aagatcccgt ttgttctgct aaatccttgt 9480 tttatgtatg tctcctcttc cctgcccctg cagactatat tgaactccat gcacaaatac 9540 cagccccggt tccacattgt aagagccaat gacatcttga aactccctta tagtacattt 9600 cggacatact tgttccccga aactgaattc atcgctgtga ctgcatacca gaatgataag 9660 gtaaactcaa ggggctttcc tttttaatgg tgatattttg ccttcccctt aaaagctgct 9720 ttaagtcagg atgagaaagt tacaagagag tggagacgag agtcttgagt tgtcttttgt 9780 gatttgtgga gcatttgggg ggaaaggaca atgacacctc gaggagacag aaaaacacct 9840 tgactaggta ggaacaatgc tgagcaaaaa aacgccatac taattttgcc acagagaaac 9900 tcctagaact gctgtcattg atgccaccca ctcctccccc cctcttgggc tttgtcctgt 9960 ctgttttaag gttcatcttc ttccccttgg ggaagaagga tcaagaagtc acattcaaaa 10020 ggaaccagct aaaaatttaa ggcaaaagcc atttgggatc ctgggaggag aatcctagta 10080 gagaccagct tttctcccct agccagaaat cctgagtagc tggtctggtt tttattacct 10140 tttatgctgc tgtgttatga tgtgtgtgtg tgtgtgcatg tgtgtgcatg catgcgtgtg 10200 gttggaaaaa cctaccctga tcacagggtc atattaatcg agttgtctga ggcttttgag 10260 ttggggtggc caaagtcacc acttcatttg aattcccccc ctcccccagg cctgaatctg 10320 gaggttagaa ggatccccaa aagggaaagc acctgatatc tagagctatg gtggcctgaa 10380 ggtcatgggc acagaaaaag tgacccttac tgctgattca ccagttccca gattggctgt 10440 tagcagttat ggggtgggag gagggactga agacccctgc tctgcaatcc tggacttcaa 10500 agagagtcca ttttacctga caacacactt cattttgaac tcactgtcat tgtcactgtc 10560 cttgggtcct ctgtggactt catgatgggg atgttccagc taaatttctt tagtgtgaat 10620 accaaaacat gatcttctct ccctgtgaaa cctgaagtct tcaatagagc aatttattcc 10680 aagaacatga atccaaccaa gggtccccct ttccacctct gagtaactct gtgtatataa 10740 cttcttcttc ccaccaaggg gaagggattt gaaagattac acactatagc atttttctca 10800 aagtgcaaaa tgcatgtgcc ctctagaccc agaatcctgt gaaatgaagt tgttaatgta 10860 ataataaaat gtagcatttt tgatcagaca aaaaggccat gggccttctc cacctaatgg 10920 ccatggcaga gcatataaat gaaaacagat gtttccagtg gtcattcagt actgtaactg 10980 tcaatattgt aatttcctca aaccaccccc caggcaaaga aaaaaaaaat taaactcact 11040 cccgcactca ctcccgcaca agggtagtga aaccccataa atcatttatt ggattcatgg 11100 aaaaggagtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgaaggga gtatgctata 11160 atttatgatt aattgcactg tataaaaatc aaaatgaaag cataatttta agatctacag 11220 gttttccctc ttgatgactt tgacaacact tccatgtcta aacccaaact gttggctgcc 11280 caaagaaaag aatttctttg aataatttca tccccaaatc cctggtttgg cctcatatag 11340 gagatacaag ccctgccaca gtttccttat tatctccttt ccctggcata tctatatgac 11400 ttctgttggc agtcacatct ctagacttgt tgagttggga aaaacaccct caaaacattc 11460 tagaaaatga gaacaatgtc tctgtcttgc ttgtgtctct tccaatagat aacccagtta 11520 aaaatagaca acaacccttt tgcaaaaggt ttccgggaca ctggaaatgg ccgaagagaa 11580 aaaaggtgag ttgaaacaat tatttattag atagtttaga aaaatccctt tttttaggat 11640 ccaactctga agtgttagaa gtgagatgca ggcacttatc ctaagagcgg gtggaaatca 11700 ttcactttcc ccactgctac atgcttgccg ctatcagtat acccaggaca agtacttttc 11760 ctacctcctt acctttaagg aaattaacta ggctacacca tacttatctc tggaagagaa 11820 gcatcaggga taatagatta tacagggatg cctattaatt cctaattaat ttaagttcat 11880 cctaggcagg tcccagaaag aaccatgcca ttgagaaaat acttgggaat ttttgcaatc 11940 ctgtcttcca aataccatca gacagagctg gggacttcgg aaagatgtat ggctctctcc 12000 ctccttcgtg gggacatgta tcattttgca ttacgtagac agctggagag tatatgaaag 12060 agggtctccc ctcccccacc ccctttcaaa gaatttctaa aatccagaaa atcaccccca 12120 aatttttaac ctatcccctt ggggcgggca ttaaaaaata attgctaaca gctaaatata 12180 tttttattcc aattaatttg ttagtaaaac gattacagta aagtgcagca tgaaataacc 12240 acttcctccc aatcttagcc accatccaaa atttgggtat gctggggaca gacagcgttg 12300 tgtttgcagg attggacacc cggttctccc tatataaggc tggcagtcca gctgtctctg 12360 actagatcca gcctcttctc ctgcttttaa ataaaatttc acagcccaag caaatgcctt 12420 ttcctaatga aaccccatct tgaataaatg caactgaagc ctccttcctt tctccctaac 12480 cctctgccac actcttcagc ccagttagag ggtcaaggac aaagcttggg tctatgtggc 12540 tgccctgggg caagcagatt tcagtgaatt agcgttgtcc ctgggcagca ggcagggtgt 12600 gaggtatgtg tgtgccgctt tggaaagggt aagggaaaca aagaggggaa atgtatgtta 12660 cattctgtaa cctgggtgtg ggcttctgcc acagaaaaca gctcaccctg cagtccatga 12720 gggtgtttga tgaaagacac aaaaaggaga atgggacctc tgatgagtcc tccagtgaac 12780 aagcagcttt caactgcttc gcccaggctt cttctccagc cgcctccact gtagggacat 12840 cgaacctcaa aggtaaacca tgtcaccttt gtgatcactg gactccagtc cctcgtggcc 12900 tggaagagtt gaagggggat ggggcaccaa ccagggcact tgccctttaa aagctagaag 12960 ccttctaaac atccttaaac agaagccaga gttcaaaaag ggctatcagg tgtgtctccc 13020 cttccccgct aaggcagtag aaggagagca cagaggcctt tctcccagat ccttatttgg 13080 ctggtgggga ggggaggtgg gtgtctgttt gcatactacc tcttggcaag cagctttgaa 13140 aacttgcttg aagcgcttct ctcttttctc tctgtctctg tttctttctc ctcccattct 13200 ctccaaccaa cagaggctcc aactgctgac ttttcactgt ctttgaactc taggttacaa 13260 tgtgttggac tgggtggggg ggaagcaagg gactctgcca cctggaaccg agaaggtggc 13320 ctagaaaaca tccagctata aagcaacaat tgacctggga gaggaggtgg agcactgggg 13380 atctgcggtg ggggtagagc tgggggaggt gggtgaggag tggacaagat ggctcaaatc 13440 ccccctcagt tacctgtgtt taaagagcaa gcagtattta tttggaaaga cacacacaca 13500 cacacacaca cacacacaca cacacacaca ctctcaacgg gaagaaacct gttttttagt 13560 gaaataaaat gcaagtcctt tatgtcttca atccatttaa gctttaaaca taaaatagga 13620 tccctttttc ttttcttctg gtggaacacc cacagagggt gtggtaaaag cgaaaaaaga 13680 atctatgatc gtccccgggc tgtgagccat ctgtccgaca ctcatctctc tctgcaggga 13740 ctggggcaaa tacaaacggt tcaactgagt actggtgttg aaggacaggt gtccgttctg 13800 ccattatcaa ttcagatgtc agggttcttg ccaaacaaat ccttccagag taattcacaa 13860 atttgtggaa ggtgctgctc tctgtcattc actgattttt tgatagtaat tagaatatgt 13920 tccagctgtg agttttaatg ttacttttta cttttaaaaa gttaatttgc aatcgaatgg 13980 ggagatgcat gtgaaatctg ccactgtagg aactcaaaaa aagaagtaaa attcattaaa 14040 ataagaagag ctactgatta ggggattgtc catctaaggg aaagtttaaa ctctgggtaa 14100 atactttaaa ttcataatcg cttattgaat tttccagcaa tgttgttggg cacgattatc 14160 cccattttgc agatgacaac actgaggtgc agagaggcta aggggctttc cccgggatta 14220 cacagccact aagccacgag ctgggattcc aacttgggaa ctggagttcc gttggctcat 14280 actggagata acgcccttct gccttggttt tttccttcgc ctgtggtaga tttatgtccc 14340 agcgagggtg agagcgacgc cgaggccgag agcaaagagg agcatggccc cgaggcctgc 14400 gacgcggcca agatctccac caccacgtcg gaggagccct gccgtgacaa gggcagcccc 14460 gcggtcaagg ctcacctttt cgctgctgag cggccccggg acagcgggcg gctggacaaa 14520 gcgtcgcccg actcacgcca tagccccgcc accatctcgt ccagcactcg cggcctgggc 14580 gcggaggagc gcaggagccc ggttcgcgag ggcacagcgc cggccaaggt ggaagaggcg 14640 cgcgcgctcc cgggcaagga ggccttcgcg ccgctcacgg tgcagacgga cgcggccgcc 14700 gcgcacctgg cccagggccc cctgcctggc ctcggcttcg ccccgggcct ggcgggccaa 14760 cagttcttca acgggcaccc gctcttcctg caccccagcc agtttgccat ggggggcgcc 14820 ttctccagca tggcggccgc tggcatgggt cccctcctgg ccacggtttc tggggcctcc 14880 accggtgtct cgggcctgga ttccacggcc atggcctctg ccgctgcggc gcagggactg 14940 tccggggcgt ccgcggccac cctgcccttc cacctccagc agcacgtcct ggcctctcag 15000 gtatggatcc ttcttcctgc ctccaccagt ctttccacct ttcgtccagt ttccctgtcc 15060 tttgccagca gaccctcacc cgatcccttt ggcctagtag ctgtaataat ttttactgag 15120 ccattaccgg gttcaaggct tagctcatgg agttattatg acttcattct ccccattcac 15180 cccaaaaatc tttaaaattt ttccgaagtt aaaggctgtt tccagcagag tagataggta 15240 gtaacaaaga taacagctgg acacagcact tactttcagg cattcttcta agtgcttgct 15300 ctgtattgac tcatttgacc taacccttca ggggtactat tatcacctcc actttacaga 15360 tgaaggcgaa gacgcccaga gatgttgagt gacttgtcca aggtcacaca gcgggtacat 15420 ggtggagctg agactcaacc ccaggctatc tgactccagg gcctctttga gggtttctga 15480 ttttagcttc agagctgaca tgtctcttaa gtgtctcata gccaaccctt ccccaggaat 15540 gggactctag gcctggggag gggaagtgac tacttcctga gtaggagttc agtcttgatt 15600 cctccagcct ttcctcccag ttcgaagctc ttctccccac ccccaacccc aagcaggcca 15660 gcctattcct cgaagggtta atggtttgtg cacacgtggg aaatgtcaga ggacagggat 15720 aagcagggac tggggcaggc ctggaggcct gtgtgtggct cagacagctg tgctgggggg 15780 aggtctcagg cggctggaaa caccctgaac tcgatgaaaa ggttctatga ggttttgcat 15840 gctgttgcct tttgttttgt ctgagcacat tcgtctggtc tcccttccct gcgccaagaa 15900 accagattgg cctccccact ccagggagga gggagctgag gaaaggcttg gcttctggca 15960 tttctcaatt cctcccatct cctctgctgg cttctccggg agaccctgtc ctaggtgggc 16020 aggtggttgg tacaccaagg actacctgaa cagacaaaac cttaagggca cctcaaggca 16080 tgatgcagag aactggccca ggccagggtg cctgcatctt aaatgctgct tctgccaatt 16140 cccagcttag tgcactcctg aactcctgcg gcctacctcg gcttctcacc tggaacacca 16200 gtgaatcatg ctggacgatt tctttgtctc tgtttataac aaatgccctt tttccctccc 16260 ccagccccag tttccttttg cttaagatct tcactgtctg ttttttttgt tttgttttgt 16320 tttgtttgga gaaacttcta ggattggggt gggaggatgg gggttgggga agaagaaaga 16380 tttaaaaaat tattcctact aatttatgtc ctccggcttc cccttggtta cctctgtggg 16440 gtaaactgaa tctgtatccc catttaacag gtgcaaggag atttcctggg ggctgcacac 16500 actgtgtgca gcatattgca ggctttcact catttaatat ctacaaagtc ctcaataagt 16560 atatgaatta cttatgattt ccctgttttt tcttcctata aggaagctga ggcacaagtt 16620 aatcaaagtc tcttggccta gggtgacaca gctaagattt gtacctagag atttctgagt 16680 gttgacttct ctcctgcccc cacctatctc cccccccaaa aaaaaaaaca caacaacaac 16740 aacaacagaa cataccaggg attcatggct tgcccaatgt tggaggggga gaagagagga 16800 gagggatgag ataagctcct cccacccggc tgactcgctg tgtgtctctt ttctcacccc 16860 agggcctggc catgtcccct ttcggaagcc tgttccctta cccctacacg tacatggccg 16920 cagcggcggc cgcctcctct gcggcagcct ccagctcggt gcaccgccac cccttcctca 16980 atctgaacac catgcgcccg cggctgcgct acagccccta ctccatcccg gtgccggtcc 17040 cggacggcag cagtctgctc accaccgccc tgccctccat ggcggcggcc gcggggcccc 17100 tggacggcaa agtcgccgcc ctggccgcca gcccggcctc ggtggcagtg gactcgggct 17160 ctgaactcaa cagccgctcc tccacgctct cctccagctc catgtccttg tcgcccaaac 17220 tctgcgcgga gaaagaggcg gccaccagcg aactgcagag catccagcgg ttggttagcg 17280 gcttggaagc caagccggac aggtcccgca gcgcgtcccc gtagacccgt cccagacacg 17340 tcttttcatt ccagtccagt tcaggctgcc gtgcactttg tcggatataa aataaaccac 17400 gggcccgcca tggcgttagc ccttcctttt gcagttgcgt ctgggaaggg gccccggact 17460 ccctcgagag aatgtgctag agacagcccc tgtcttcttg gcgtggttta tatgtccggg 17520 atctggatca gattctgggg gctcagaaac gtcggttgca ttgagctact gggggtagga 17580 gttccaacat ttatgtccag agcaacttcc agcaaggctg gtctgggtct ctgcccacca 17640 ggcggggagg tgttcaaaga catctccctc agtgcggatt tatatatata tttttccttc 17700 actgtgtcaa gtggaaacaa aaacaaaatc tttcaaaaaa aaaatcggga caagtgaaca 17760 cattaacatg attctgtttg tgcagattaa aaactttata gggacttgca ttatcggttc 17820 tcaataaatt actgagcagc tttgtttggg gagggaagtc cctaccatcc ttgtttagtc 17880 tatattaaga aaatctgtgt ctttttaata ttcttgtgat gttttcagag ccgctgtagg 17940 tctcttcttg catgtccaca gtaatgtatt tgtggttttt attttgaacg cttgctttta 18000 gagagaaaac aatatagccc cctacccttt tcccaatcct ttgccctcaa atcagtgacc 18060 caagggaggg ggggatttaa agggaaggag tgggcaaaac acataaaatg aatttattat 18120 atctaagctc tgtagcagga ttcatgtcgt tctttgacag ttctttctct ttcctgtata 18180 tgcaataaca aggttttaaa aaaataataa agaagtgaga ctattagaca aagtatttat 18240 gtaattattt gataactctt gtaaataggt ggaatatgaa tgcttggaaa attaaacttt 18300 aatttattga cattgtacat agctctgtgt aaatagaatt gcaactgtca ggttttgtgt 18360 tcttgttttc ctttagttgg gtttatttcc aggtcacaga attgctgtta acactagaaa 18420 acacacttcc tgcaccaaca ccaataccct ttcaaaagag ttgtctgcaa catttttgtt 18480 ttctttttta atgtccaaaa gtgggggaaa gtgctatttc ctattttcac caaaattggg 18540 gaaggagtgc cactttccag ctccacttca aattccttaa aatataactg agattgctgt 18600 ggggagggag gagggcagag gctgcggttt gactttttaa tttttctttt gttatttgta 18660 tttgctagtc tctgatttcc tcaaaacgaa gtggaattta ctactgttgt cagtatcggt 18720 gttttgaatt ggtgcctgcc tatagagata tattcacagt tcaaaagtca ggtgctgaga 18780 gatggtttaa agacaaattc atgaaggtat attttgtgtt atagttgttg atgagttctt 18840 tggttttctg tatttttccc cctctcttta aaacatcact gaaatttcaa taaattttta 18900 ttgaaatgtc tttgggcctt gtgttaaatg ttttttcttt gggaaccttt cctgaagatg 18960 gacagtcagg ggagggttta gtatcttctt gttctgagtt tacccccttc ccttcgcctt 19020 taaataatta agaccgcccc cagcgaacca aaatgagatg tcactcaagt tacaaagcta 19080 aaaacaaaag tcccttactt gagcgaaggg agccacttca atctgaaatt acttttcctt 19140 taaattaggg agcaaagcag ggagacggaa aggggcctga tgagaataca gaaagaaggg 19200 taatttcaga tacttttaag ttttaatgga aaaagactga tgtgctccct aagtcaggtt 19260 ttcccacccg aatccgacca aaagtaagct cggcaagtac gaatgttttt cgttttaagc 19320 tcgccctcag ttttgacatc aatctggcga atccaagtcg aaaatacctt cttgcaccag 19380 tgtgtttggc tcggggaaaa ggccagcaga atgccccagc agtccgagcg ggcttggcta 19440 ggcagcaacc ctccaggttg tagaagtgga caagacgcaa cgcctttcca ctcggcaacc 19500 ccccacacag cctgcagtcc ctggtgcctc aaattgaacc cggctggccc aaggcgcccc 19560 tacgaggccc catccatccc gagttgtgcg tgcaaagcgc ggccagctcc gcgaaaactt 19620 agctgtgtca cgcgagggag gagggaaatt atccccgaaa ggggaaaggt aattccaggg 19680 tgcacatttc accccctcca cggcaaaagt cacccaggag gctgacatcc tcccctagtc 19740 tccccttcaa acccgtctcc aggctgttcg gggagttgcc ttttgaagtt caatttatct 19800 ttgaaacatt caataaaaaa tgatgaggca ctgtcagtct tttggtctcc cgacccccag 19860 cctcgcctcc gaggtgtgtg tctgttgggg ggcgggggcg gcacgggaag gttcgagggt 19920 tagtccttag cccttttctt gccctggggg ccatgacgtg aagacccagc tggagcctgc 19980 ctggcggctg cctccctccc caccccccac ccgccacccc ctggagcccg ccagcccggc 20040 cccaagtccc tgtcaccttc aggcctcttg aatgaccgga gaggaggacg ccccctccct 20100 tccctcatcc tgtacttgga agggatcgag gtcgagacct tttggagagc ggggcaaagc 20160 cccttccatc tctggccagg cacgtgggga cccctacagc ctcctctgcg atgtctccgg 20220 gggtgggagg gaagacagac aaccagagta tgttggtgcg gagtcgcggg gggggggagg 20280 ggcggggtgc gctgcggggg tggcagggcc tgagctgaga cgggccctgg ggacctttga 20340 ggctggggct cccccgagga ctgggagatt tccagggcgc gctccttctg cgcagcggct 20400 acagcctgaa gggggcagct ctggatccag cgacaacgcg cggtgtccgc gcctctgaga 20460 aggtggtagt tggctggttg cgctctcccg aattggggaa aaaagaactc agcctccaaa 20520 agggaagaaa tgctttgctt ttctcttctt tctcagtcca aatttgctta cctcctccct 20580 tctctccccc cgcccccgat ttggggaccc tgctcagact tgtgtccagc ctctcttact 20640 ggcgttcctc tttttttttt tttttttttt ttaatctcct gtgtatctca tttgtatatt 20700 gtgatgttaa tgagtaactc ctgtagcgct gatgggcggg gggtggaggg gatgaacggc 20760 tcgcagtctc tctggatttt gctgcctatt actcacctgg cgccggtcgc aatctcgccg 20820 caggctttat ggtggctgcg gccgccccag aggccactca gggcaggcgc cttcgccttt 20880 tttctgggct tcgagtgcca cctatctgtc t 20911 <210> 15 <211> 305 <212> DNA <213> Homo sapiens <400> 15 cagcaggcgc gctcccggcg aatctgcctg aatcgccgtg aatgcggtgg ggtgcagggc 60 aggggctggt tttctcagcc ggtcttggct tttctctttc tctcctgctc caccagcagc 120 ccctccgcgg gtcccatggg ctccgcgctc agaacagccc ggaaccaggc gccgctcgcc 180 gctcgctggg ggccacccgc ctctccccgg aacagcctcc cgcgggcctc ttggcctcgc 240 actggcgccc tcacccacac atcgtccctt tatccgctca gacgctgcaa agggccttct 300 gtctc 305 <210> 16 <211> 336 <212> DNA <213> Homo sapiens <400> 16 gctttggatt tatcctcatt ggctaaatcc ctcctgaaac atgaaactga aacaaagccc 60 tgaaccccct caggctgaaa agacaaaccc cgcctgaggc cgggtcccgc tccccacctg 120 gagggaccca attctgggcg ccttctggcg acggtccctg ctagggacgc tgcgctctcc 180 gagtgcgagt tttcgccaaa ctgataaagc acgcagaacc gcaatcccca aactaacact 240 gaacccggac ccgcgatccc caaactgaca agggacccgg aacagcgacc cccaaaccga 300 cacgggactc gggaaccgct atctccaaag ggcagc 336 <210> 17 <211> 139 <212> DNA <213> Homo sapiens <400> 17 tttccacaac agggagccag cattgaggcg cccagatggc atctgctgga aatcacgggc 60 cgctggtgaa gcaccacgcc ttacccgacg tggggaggtg atcccccacc tcatcccacc 120 cccttctgtc tgtctcctt 139 <210> 18 <211> 292 <212> DNA <213> Homo sapiens <400> 18 gctggacaag gagcgctcac tgtagctctg ctgtggattg tgttggggcg aagagatggg 60 taagaggtca aagtcgtagg attctggcga ccgcctacca agggattggg tccacagcac 120 agaggtctga tcgcttcctt ctctgctctg ccacctccag acagcagctc taaccagctg 180 cccagcagca agaggatgcg cacggctttc accagcacgc agctgctaga gctggagcgc 240 gagttcgctt ctaatatgta cctgtcccgc ctacgtcgca tcgagatcgc ga 292 <210> 19 <211> 190 <212> DNA <213> Homo sapiens <400> 19 tgcctgacac tgaccccagg cgcagccagg aggggctttg tgcgggagag ggagggggac 60 cccagcttgc ctggggtcca cgggactctc ttcttcctag ttcactttct tgctaaggcg 120 aaggtcctga ggcaggacga gggctgaact gcgctgcaat cgtccccacc tccagcgaaa 180 cccagttgac 190 <210> 20 <211> 706 <212> DNA <213> Homo sapiens <400> 20 tcggcggaga gacctcgagg agagtatggg gaaaggaatg aatgctgcgg agcgcccctc 60 tgggctccac ccaagcctcg gaggcgggac ggtgggctcc gtcccgaccc cttaggcagc 120 tggaccgata cctcctggat cagaccccac aggaagactc gcgtggggcc cgatatgtgt 180 acttcaaact ctgagcggcc accctcagcc aactggccag tggatgcgaa tcgtgggccc 240 tgaggggcga gggcgctcgg aactgcatgc ctgtgcacgg tgccgggctc tccagagtga 300 gggggccgta aggagatctc caaggaagcc gaaaaaagca gccagttggg cttcgggaaa 360 gacttttctg caaaggaagt gatctggtcc cagaactcca gggttgaccc cagtacctga 420 cttctccggg agctgtcagc tctcctctgt tcttcgggct tggcgcgctc ctttcataat 480 ggacagacac cagtggcctt caaaaggtct ggggtggggg aacggaggaa gtggccttgg 540 gtgcagagga agagcagagc tcctgccaaa gctgaacgca gttagcccta cccaagtgcg 600 cgctggctcg gcatatgcgc tccagagccg gcaggacagc ccggccctgc tcaccccgag 660 gagaaatcca acagcgcagc ctcctgcacc tccttgcccc agagac 706 <210> 21 <211> 325 <212> DNA <213> Homo sapiens <400> 21 agatcccggt gcatttaaag gccggcgtga tctgcaccac gtacctatct cggattctca 60 gtttcacttc gctggtgtct gccaccatct ttaccacatc ccggtagcta catttgtcta 120 ccgcttgagc caccagcgtc tgaaacctgg accggatttt gcgcgccgag aggtagccgg 180 aggcggtaat gaattccacc cagagggaca tgctcctctt gcgcccgtcg ctcaacttca 240 gcaccgcgca gccgggcagt gagccatcgt ccacgaagtt gaacaccccc atttggttga 300 gataaagcac cacttcaaat tcggt 325 <210> 22 <211> 663 <212> DNA <213> Homo sapiens <400> 22 actatgcctt gagggtcaaa acgtctggat ttcctgatcg atgctgtcgt cgctgtccac 60 ggagctactg tcgccgtcag agcgggaagg cacgttcagg gagtagaagc gtgggcttgc 120 agaaagggac ctgttgctgc cttacatggg ggccggcagg gtagtcttgg aaatgcccaa 180 gattgcttcc gcgcgcgtca gttcagcgga cgtgtctgcc tggcacgagg accgttctac 240 aaactcgttc ctggaagccg ggctcgctgg aggcggagct ttggtttcct tcgggagctt 300 gtggggaatg gtcagcgtct aggcaccccg ggcaagggtc tgtggccttg gtggccactg 360 gcttcctcta gctgggtgtt ttcctgtggg tctcgcgcaa ggcacttttt tgtggcgctg 420 cttgtgctgt gtgcggggtc aggcgtcctc tctcctcccg gcgctgggcc ctctggggca 480 ggtccccgtt ggcctccttg cgtgtttgcc gcagctagta cacctggatg gcctcctcag 540 tgccgtcgtt gctgctggag tctgacgcct cgggcgcctg cgccgcactt gtgacttgct 600 ttccccttct cagggcgcca gcgctcctct tgaccccgct tttattctgt ggtgcttctg 660 aag 663 <210> 23 <211> 1985 <212> DNA <213> Homo sapiens <400> 23 gcaagtcggg tagctaccgg gtgctggaga actccgcacc gcacctgctg gacgtggacg 60 cagacagcgg gctcctctac accaagcagc gcatcgaccg cgagtccctg tgccgccaca 120 atgccaagtg ccagctgtcc ctcgaggtgt tcgccaacga caaggagatc tgcatgatca 180 aggtagagat ccaggacatc aacgacaacg cgccctcctt ctcctcggac cagatcgaaa 240 tggacatctc ggagaacgct gctccgggca cccgcttccc cctcaccagc gcacatgacc 300 ccgacgccgg cgagaatggg ctccgcacct acctgctcac gcgcgacgat cacggcctct 360 ttggactgga cgttaagtcc cgcggcgacg gcaccaagtt cccagaactg gtcatccaga 420 aggctctgga ccgcgagcaa cagaatcacc atacgctcgt gctgactgcc ctggacggtg 480 gcgagcctcc acgttccgcc accgtacaga tcaacgtgaa ggtgattgac tccaacgaca 540 acagcccggt cttcgaggcg ccatcctact tggtggaact gcccgagaac gctccgctgg 600 gtacagtggt catcgatctg aacgccaccg acgccgatga aggtcccaat ggtgaagtgc 660 tctactcttt cagcagctac gtgcctgacc gcgtgcggga gctcttctcc atcgacccca 720 agaccggcct aatccgtgtg aagggcaatc tggactatga ggaaaacggg atgctggaga 780 ttgacgtgca ggcccgagac ctggggccta accctatccc agcccactgc aaagtcacgg 840 tcaagctcat cgaccgcaac gacaatgcgc cgtccatcgg tttcgtctcc gtgcgccagg 900 gggcgctgag cgaggccgcc cctcccggca ccgtcatcgc cctggtgcgg gtcactgacc 960 gggactctgg caagaacgga cagctgcagt gtcgggtcct aggcggagga gggacgggcg 1020 gcggcggggg cctgggcggg cccgggggtt ccgtcccctt caagcttgag gagaactacg 1080 acaacttcta cacggtggtg actgaccgcc cgctggaccg cgagacacaa gacgagtaca 1140 acgtgaccat cgtggcgcgg gacgggggct ctcctcccct caactccacc aagtcgttcg 1200 cgatcaagat tctagacgag aacgacaacc cgcctcggtt caccaaaggg ctctacgtgc 1260 ttcaggtgca cgagaacaac atcccgggag agtacctggg ctctgtgctc gcccaggatc 1320 ccgacctggg ccagaacggc accgtatcct actctatcct gccctcgcac atcggcgacg 1380 tgtctatcta cacctatgtg tctgtgaatc ccacgaacgg ggccatctac gccctgcgct 1440 cctttaactt cgagcagacc aaggcttttg agttcaaggt gcttgctaag gactcggggg 1500 cgcccgcgca cttggagagc aacgccacgg tgagggtgac agtgctagac gtgaatgaca 1560 acgcgccagt gatcgtgctc cccacgctgc agaacgacac cgcggagctg caggtgccgc 1620 gcaacgctgg cctgggctat ctggtgagca ctgtgcgcgc cctagacagc gacttcggcg 1680 agagcgggcg tctcacctac gagatcgtgg acggcaacga cgaccacctg tttgagatcg 1740 acccgtccag cggcgagatc cgcacgctgc accctttctg ggaggacgtg acgcccgtgg 1800 tggagctggt ggtgaaggtg accgaccacg gcaagcctac cctgtccgca gtggccaagc 1860 tcatcatccg ctcggtgagc ggatcccttc ccgagggggt accacgggtg aatggcgagc 1920 agcaccactg tcctaggaca tgtcgctgcc gctcatcgtg actctgagca ctatctccat 1980 catcc 1985 <210> 24 <211> 213 <212> DNA <213> Homo sapiens <400> 24 atgcgccctc tgcaccccta gagccagaag acgctaggtg ggctgcgcgc tctgccaggc 60 gaaggctgga gcgcagacgg caaagccgcg cgtttcagcc gtggtcgggt ccgcaggacc 120 tgggcgtggg gacaccacca ggcaggagca gaggcaggac tgggacgcca aaagctgaga 180 atcctcgatg cccgcgcgag agccccgtgt tat 213 <210> 25 <211> 1558 <212> DNA <213> Homo sapiens <400> 25 ttctggaaac cgggccccac ttgcaggccc ggccaccttg ggttctggtg gccgaagccg 60 gagctgtgtt tctcgcagac tcggggagct acattgtgcg taggcaattg tttagtttga 120 aaggaggcac atttcaccac gcagccagcg ccctgcatgc aggagaagcc cccagggccc 180 agggtcggct ggctttagag gccacttagg ttgttttaag cacatgtgaa agggcagaca 240 gcaggggagc aggatatggg taagatcttc gggtctcaga acaggggctg cccttgggct 300 gtcccggcgc cctgggctct gacactgaag ggtggaatgg aggaaggaat ggagaaagga 360 cggtggaact ttcgcttccc ctctgggccg ccttcccagg gtcatgcctg agctgctttg 420 atcccagtgt cgcgcatctt ggtccgctac ctcccaggcg atagctactg ggctcctcgc 480 tggcctcact gggggccatc ccgggcagtg gcctgccctc cgaggcccgc gggacccagc 540 ccagagctga ggttggagtt ctccgggcca cgttccgggt cgcttaggct cggagatttc 600 ccggagaccg tcgtcctccc tttctgcttg gcactgcgga gctccctcgg cctctctcct 660 cctctggtcc ctaaggcccg gagtggttgg cggtactggg gcccgtcgtc atctctgctt 720 ctaaggcatt cagactgggc tccagctggg accggcagag gaggttctca aggaaactgg 780 tgggaaatat agttttcttt cgtctggtcg tttaatttaa atgcaacttc ccttggggac 840 attttcctgg acgttaacca gaccaccttg agatgtcgtt gatgacctag agacccagat 900 gatgcgtccc aggaaagttc actgctgact attgtcactc ttggcgttat atctatagat 960 atagacctat gtacatatct ccaccctgat ctctccgtgg acatgaaacc cacctacctt 1020 gtgaaagccc tacgggtgac acatgactac tacgtctctg tcccaacagg ggctgggcct 1080 cccctgccta atagttgcca ggagtttcgc agcccaagtg aataatgtct tatggctgaa 1140 cgtggccaag gactcctgtg atttaggtcc caggaggagc agagacgtcc ccgccccgcc 1200 tgggccctgc cgcattcaaa gctggaagaa ggcgctgatc agagaagggg cttccaggtc 1260 ctgggttaga acaacaacaa acaaacgaaa ctccacaaca gacacgcctg cccatgaccc 1320 cacgcaagga cataggaagt tctgtcgcct tcctgctccg cggatagccg cctgccgtct 1380 gctgccacca gaacgcacgg acgctcgggg tggaggtagt caatgggcag caggggaccc 1440 ccagccccca caagcgcggc tccgaggacc tggaagcggg tgcctgtcgc tctccgcagg 1500 ctccgctctg cctccaggag caagatcccc aaaagggtct ggaagctgtg gagaaaac 1558 <210> 26 <211> 1264 <212> DNA <213> Homo sapiens <400> 26 ttttttaaac acttcttttc cttctcttcc tcgttttgat tgcaccgttt ccatctgggg 60 gctagaggag caaggcagca gccttcccag ccagcccttg ttggcttgcc atcgtccatc 120 tggcttataa aagtttgctg agcgcagtcc agagggctgc gctgctcgtc ccctcggctg 180 gcagaagggg gtgacgctgg gcagcggcga ggagcgcgcc gctgcctctg gcgggctttc 240 ggcttgaggg gcaaggtgaa gagcgcaccg gccgtggggt ttaccgagct ggatttgtat 300 gttgcaccat gccttcttgg atcggggctg tgattcttcc cctcttgggg ctgctgctct 360 ccctccccgc cggggcggat gtgaaggctc ggagctgcgg agaggtccgc caggcgtacg 420 gtgccaaggg attcagcctg gcggacatcc cctaccagga gatcgcaggt aagcgcgggc 480 gcgctgcagg ggcaggctgc agccctcggc tgccgcacgt cccactggcc gcccggcgtc 540 cccttccttc cccctgttgc tgagttggtg ctcactttct gccaccgcta tgggactccg 600 cgtctccgtg ttgggcggcg gatgctcctg cggcttcttc ggcgggggaa ggtgtgcgtc 660 tccgccgcct cattgtgtgc acacgcggga gcaccctggc tcccgcctcc cgctgctctc 720 gcgcccttct accccttagt tgatggctca ggcccggctg gccagggagc ccgggtcact 780 ccggggcggc tgcaaggcgc agacggagag ccgagccggg cgctcactcc gcgttctggt 840 tcgggcaaac ttggaagaac tgcgaccgca gtttgcccag cgccacagtc tgagtggcgc 900 cttctccact cccgcccttg cgccggcagg ggcggtggag agacgcggag ggctccccca 960 gcccctctct cccctatccg tccttcgggc gacagagcgc ccggcgctcg ggccgggggc 1020 gggcaaggct gggagggacc ctcgccgggg acctggcctc tggacgccgg cgtttcaagg 1080 ctggtttggg gacttcacgg gctgcctgtt tcagatgtgg ggcgggcttt cccgttaggg 1140 ttcctcagtg cttccccagt tgctgttggc cactcagggc ccggggacac cctgccaccc 1200 ggtctggagc cggcctcgtc tgccagcgaa cagccaactt tagcgggtgg ctcagctggg 1260 gatt 1264 <210> 27 <211> 761 <212> DNA <213> Homo sapiens <400> 27 cactcagtgt gtgcatatga gagcggagag acagcgacct ggaggccatg ggtgggggcg 60 ggtggtgaag ctgccgaagc ctacacatac acttagcttt gacacttctc gtaggttcca 120 aagacgaaga cacggtggct tcagggagac aagtcgcaag ggcgactttt ccaagcggga 180 gatggtgaag tctttggacg tgtagtgggt aggtgatgat ccccgcagcc gcctgtaggc 240 ccgcagactt cagaaaacaa gggccttctg tgagcgctgt gtcctccccg gaatccgcgg 300 cttaacacat tctttccagc tgcggggcca ggatctccac cccgcgcatc cgtggacaca 360 cttagggtcg cctttgtttt gcgcagtgat tcaagttggg taacccttgc tcaacacttg 420 ggaaatgggg agaatctccc ccacccgcaa cctcccgcac cccaggttcc caaaatctga 480 atctgtatcc tagagtggag gcagcgtcta gaaagcaaag aaacggtgtc caaagacccc 540 ggagagttga gtgagcgcag atccgtgacg cctgcggtac gctagggcat ccaggctagg 600 gtgtgtgtgt gcgggtcggg gggcgcacag agaccgcgct ggtttaggtg gacccgcagt 660 cccgcccgca tctggaacga gctgcttcgc agttccggct cccggcgccc cagagaagtt 720 cggggagcgg tgagcctagc cgccgcgcgc tcatgtttat t 761 <210> 28 <211> 1198 <212> DNA <213> Homo sapiens <400> 28 agtcactcca ggatcagagg ccgcgtcggt tctgcttggg gcatgggcag agggaggctg 60 ctggggccaa gccccggctg gacgcgaggg aagaaactcg tcccaggacc cgcacgccca 120 tacctggctg tcccagagct cttccctagg ccggcacctt cgctcttcct cttccccacc 180 ccctagccct tttgtctctt tttcagacgg atgttttcag tctcaagtgg ttttattttc 240 cgcacaaaac cctgagatca agggcagatc acagactgta ccggaggctc gggtttccct 300 ggactctgtg ctgttctgcg tcccagggtt ggctaggaag gaaggcctgg gccggcgagg 360 tgacgggtct cccgcccagg tcggcaggac ggggggaggt gtgtcccggt aggtccctgg 420 tgagctcacc cgtggcatcg gggacccgcg ggaacccacc gggcgcccac tagagactcg 480 ggtcctaccc tcccccacac tactccaccg aaatgatcgg aagggcgcgc taggcctgct 540 tccaagggct cagtgataaa ggcctcaaaa tcacactcca tcaagacttg gttgaagctt 600 tgggtaggtt tgttgttgtt gttgttgttg tttgtttgtt tgttttagca gacacgtcct 660 ggaaagaggt cctcagaacc caaaggttca ataatgattt gtggatggat tgattatagt 720 ctgatatcgc tctggttcca cagaaacccg gagctccttg gcccactgtt accccagcag 780 acctaaatgg acggtttctg tttttcactg gcagctcaga actggaccgg aagaagttcc 840 cctccacttc ccccctcccg acaccagatc attgctgggt ttttattttc gggggaaaaa 900 caacaacaac aacaacaaaa aaaacactag gtccttccag actggatcag gtgatcgggc 960 aaaaaccctc aggctagtcc ggctgggtgc ccgagcatga aaaggcctcc gtggccgttt 1020 gaacagggtg ttgcaaatga gaacttttgt aagccataac cagggcatcc tgagggtctg 1080 agttcacggt caaggctgtg ggctactagg tccagcgagt ccaggcctcg ccccgccccc 1140 gagctgccac agccaagatc ttcggcaggg aattcgagac cagggtcctc ccactcct 1198 <210> 29 <211> 377 <212> DNA <213> Homo sapiens <400> 29 tttcgtgccg ctgttttcaa tgcgctaacg aggcacgtta ttcttagccg cgtccgggag 60 gggatcacat tcctgcgcag ttgcgctgct ggcggaagtg acttgttttc taacgaccct 120 cgtgacagcc agagaatgtc cgtttctcgg agcgcagcac agcctgtccc atcgagaagc 180 ctcgggtgag gggcccggtg ggcgcccgga ggccgctgga gggctgtggg agggacggtg 240 gctccccact cccgtggcga agggcaggca aaccagaagc ctcttttgag agccgtttgg 300 gattgagacg agtaagccac agcgagtggt tagaagtagg ttaggaagaa ggggaggtaa 360 gaaagccgag tagggtt 377 <210> 30 <211> 256 <212> DNA <213> Homo sapiens <400> 30 gttcggtgga caagggggca gcgcccacag caagccggaa agagggaggc gcggggccgc 60 gcttggggcc tgccgctgca cgccagcctg ggcaaagagc tgccaccttc tgcgggcgaa 120 gcgggtcggg acgcaggacg gcagcggggc tggaggcagc tacgtgggtc cacaccccca 180 tgccctgcaa ggctccttgg ccctgcttct cctctgtctc ggcgggagag gagcagcctc 240 ggttttacag aatttc 256 <210> 31 <211> 189 <212> DNA <213> Homo sapiens <400> 31 tgtgccattt agtgagaggt gttttgggca aagaatcaat ttaactgtga ctgaccgacg 60 ggcttgactg tattaattct gctaccgaaa aaaaaaaaaa aaaaaaagca atgagccgca 120 agccttggac tcgcagagct gccggtgccc gtccgagagc cccaccagcg cggctcacgc 180 ctcagtctc 189 <210> 32 <211> 707 <212> DNA <213> Homo sapiens <400> 32 agagtcccag ttctgcaggc cgctccaggg ctaggggtag agatggtggc aggtggtgcg 60 tcaactctct agggaagagg aacttgcatt acaaagactt gtctttctga gctgaagtca 120 aaacgggggc gtcaagcgcg ctccgtttgg cggcggtgga ggggccgcgc gcccgcgctg 180 tcccagccgg agctgccctg gctggtgatt ggaggtttaa cgtccggaat tcaggcgctt 240 ctgcagctca gatttgccgg ccaaggggcc tcagttgcaa cttttcaaaa tggtgtttct 300 ggaaaataac aaattcagac tcaactggtg acagcttttg gctatagaga atgaaactgc 360 ttccctttgg cggtggaact cttaaacttc gaagagtgaa agaatacaat gaaataaaat 420 gccataagat cactggattt ttcagaaaaa ggaagacccc aaattactcc caaaatgagg 480 ctttgtaaat tcttgttaaa aatctttaaa tctcgaattt ccccctacaa catctgatga 540 gtgctttaag agcaaacgag caaatcccac ctcgagaatc aacaaaccca agctctggcc 600 aaggctctcc ccgcgttttc ttctcgtgac ctggggaatg tcccgcccca tcgctcacct 660 ggctcttgtc atctcgctca tcttgaagtg acccgtggac aatgctg 707 <210> 33 <211> 182 <212> DNA <213> Homo sapiens <400> 33 agctgccctc tgtggccatg agcgggtgtc cagccccttc caaggctgca ccggggagac 60 gctggttttc tgctcgctgt gaccgaacaa agcccctaag agtcagtgcg cggaacagaa 120 gagccggacc ccgacgggcc gagtcccaac gtgaggcacc cggcagagaa aacacgttca 180 cg 182 <210> 34 <211> 179 <212> DNA <213> Homo sapiens <400> 34 cctcggcagc accggcatgg ctggaggcca gtacggccag gtgtggcggg agggagcgcc 60 gtctggcttg ggtcgtccat cctgacagga cgctgcaagg gcaggagccc cgcgccccgt 120 gtcctgcgcc cccgctcgag gacaagcccc agccgccggt ctccgctggg ttccgacag 179 <210> 35 <211> 369 <212> DNA <213> Homo sapiens <400> 35 ctttaagagg ctgtgcaggc agacagacct ccaggcccgc taggggatcc gcgccatgga 60 ggccgcccgg gactatgcag gagccctcat caggcgagtg ccccgcgtcc ccctgattgc 120 cgtgcgcttc caatcgcctt gcgttcggtg gcctcatatt cccctgtgcg cctctagtac 180 cgtaccccgc tcccttcagc cccctgctcc ccgcattctc ttgcgctccg cgaccccgcg 240 cacacaccca tccgccccac tggtgcccaa gccgtccagc cgcgcccgcg ggcagagccc 300 aatcccgtcc cgcgcctcct caccctcttg cagctgggca caggtaccag gtgtggctct 360 tgcgaggtg 369 <210> 36 <211> 176 <212> DNA <213> Homo sapiens <400> 36 agacttgcag aactcgggcc ccctggagga gacctaaccg ccacggtctt ggggaggttc 60 cggagggcct cggttgtctg cactcccaac accaagaaac ccctgagacg cgaagctgcc 120 agcgtgctgc cctcagagca gggcgacgca aagccagcgg accccggggt ggcggg 176 <210> 37 <211> 167 <212> DNA <213> Homo sapiens <400> 37 tgctcggctg gggggctcgc tccgcacttt cggtgccaga aaatgcccag aggagcgggg 60 cggccccaga gcctcctttc ggggcgcgag gcccggcgcg tgtgtacgga gtccagtccc 120 cccagggagt ggggtgcccg caccttcccc tccgcgctcg gagccac 167 <210> 38 <211> 1205 <212> DNA <213> Homo sapiens <400> 38 tcttgcacac ctgcttgtag ttctgcaccg agatctggtc gttgaggaac tgcacgcaga 60 gcttggtgac ctgggggatg tgcaggatct tgctgaccga cagcacctcc tccaccgtgt 120 ccagggacag ggtcacgttg gccgtgtaga ggtactcgag caccaggcgc agcccgatgg 180 acgagcagcc ctgcagcacc aggttgttga tggcccgggg gctggtcagc agcttgtcgt 240 cgggggagga agaaggagtc ccgggctcct cctgcggcgg cggctgctgc tgctgtgacg 300 gctgctgctg cggcggctgc tgctggtcct tgggggcccc caggccgtcc tggccgccga 360 cccctccccc gagagggggg tggctggaga agagcgatcg gaagtactgc gagcaggagg 420 ccagcacggc cttgtggcaa tggaactgct ggccctgggc cgtcagggtc acgtcgcaaa 480 acagctgctt cctccacagc aggttgaggc cgtgcagcag gttgtcgctg tggctggggt 540 cgaaggtgga ggtcctgtcc ccggatctgg acatggcgag ctgactcggt gcacctggct 600 ttaaaccctc ctccaacctg gcagacaggg gtgggggatg ggagggaggg gagcagggtg 660 gtggagcggg tggggtgtgg tcggggtggg gaagggtgtg gaggggaggg gagggcgaag 720 aacaagaatc aaggctcagc ttgactccct cctggcgcgc tccggacccc gaccctagga 780 ggaaagtccg aagacgctgg atccgtgagc gccaccagaa gggccctgtc tggggtcccg 840 gcgccggttc tgcgccctgc ggctcctctc gccacctccc acacacttcg tccctcactt 900 tcctaaaacc aaccacctca gctcggctgt tggcagcaac agcagtggca gcagcgacgg 960 caaagtggcg gctgaggccg aggcacctcg tgggctcgtg tccatgccgg gccagatgaa 1020 gggaaaggcc gggaagtggg gagccggggg tgccctgaaa gctcagaggc gaccgacggc 1080 gaaggttcca ggtcaacttg tgcccgaagc tttgcttttc gcagttggcc cagtttgggg 1140 gagggggtag gaacaggggc ccgaccagcg tgcggggtgt gcgaatctta gctctccaaa 1200 agctg 1205 <210> 39 <211> 44 <212> DNA <213> Homo sapiens <400> 39 cctctgtgtt agtgccctcg ggaatttggt tgatggggtg tttg 44 <210> 40 <211> 5002 <212> DNA <213> Homo sapiens <400> 40 tgatgtcgca cctgaacggc ctgcaccacc cgggccacac tcagtctcac gggccggtgc 60 tggcacccag tcgcgagcgg ccaccctcgt cctcatcggg ctcgcaggtg gccacgtcgg 120 gccagctgga agaaatcaac accaaagagg tggcccagcg catcacagcg gagctgaagc 180 gctacagtat cccccaggcg atctttgcgc agagggtgct gtgccggtct caggggactc 240 tctccgacct gctccggaat ccaaaaccgt ggagtaaact caaatctggc agggagacct 300 tccgcaggat gtggaagtgg cttcaggagc ccgagttcca gcgcatgtcc gccttacgcc 360 tggcaggtaa ggccggggct agccaggggc caggctgctg ggaagagggc tccgggtccg 420 gtgcttgtgg cccaagtctg cgcgccgagt cacttctctt gattctttcc ttctctttcc 480 tatacacgtc ctctttcttc tcgtttttat ttcttcttcc attttctctt tctcttccgc 540 tcttccccta ctttcccttc tcccttttct ttttctttct tactctctcc ttgtccctga 600 gctttcattg accgaccccc ccccatttca ttcgccctcc cctcaatgtg ccaacctttg 660 ccctatttcc gatcttccca ggtactggga ggcgggatgg gggtgtgcgt tttcctctag 720 gagccctgtc tttccaagac ccacagaaac caggacctgc ccttattcaa aaccccatgc 780 acttcaagtc tcttttagac aacacatttc aattttccgg gctgactagt ctccctgtgc 840 agaggcagtt gagaggcttt gctctgcaga gggaaaagag ctctctactc tcccacccac 900 catataggca aacttatttg gtcattggct gaaggcacag ccttgccccc gcggggaacc 960 ggcggccagg atacaacagc gctcctggag cccatctctg gccttggcgt tggcgcaggg 1020 actttctgac cgggcttgag gggctcgggc cagctccaat gtcactacct acagcgaggg 1080 cagggtgtaa ggttgagaag gtcacattca ccgctttggg aggacgtggg agaagagact 1140 gaggtggaaa gcgctttgcc ttgctcaccg gccgtccttg ccccggtccc agcgtttgct 1200 gggatttgcc aggatttgcc ggggctccgg gagaccctga gcactcgcag gaagaggtgc 1260 tgagaaatta aaaattcagg ttagttaatg catccctgcc gccggctgca ggctccgcct 1320 ttgcattaag cgggcgctga ttgtgcgcgc ctggcgaccg cggggaggac tggcggcccg 1380 cgggagggga cgggtagagg cgcgggttac attgttctgg agccggctcg gctctttgtg 1440 cctcctctag cggccaagct gcgaggtaca gccctctatt gttctaggag cacagaaacc 1500 tcctgtgtgg gcggcgggtg cgcgagctag agggaaagat gcagtagtta ctgcgactgg 1560 cacgcagttg cgcgcttttg tgcgcacgga ccccgcgcgg tgtgcgtggc gactgcgctg 1620 cccctaggag caagccacgg gcccagaggg gcaaaatgtc caggtccccc gctgggaagg 1680 acacactata ccctatggca agccagggtg ggcgacttcc catggatcgg gtggaggggg 1740 gtatctttca ggatcggcgg gcggtctagg ggaacaattc gtggtggcga tgatttgcat 1800 agcgcgggtc ttgggatgcg cgcggttccg agccagcctc gcacagctcg cttccggagc 1860 tgcgagctca ggtttccacc cccgatcccc cgggctttcc tcgcaccgct gagcccagct 1920 tgtggggtgc actcgaccaa cgcccgacag ggctggggaa tgtgacaggc agcaggttca 1980 cccgggcttg gggaggggga gtttccgctt tgacagcatt ttcctttgcc gtctgctggt 2040 ggattcctat tcccagtcgg taatcgcccc gcagtgttga tctaagaagg taaagaaaac 2100 taggtttccc tgcaaagagc ctcccccaaa tcggcggact ccggatactt tgagtggatt 2160 tagaaattta tgtaatcttt ctcctttagt ttatttttca tcctctccta cagttttctc 2220 tgatttgctg ttggttcggg gcaagataaa gcagccagta gagagcgata ataatagcgg 2280 cgggaaatga actggagact ggctgacagt tcttaacatt ttgtcataga tccccccgaa 2340 tgtcccaggc tgtctctggt gggttttagt acccgccggc ttcttgggca ccggggacca 2400 gaaggaactt ggcagctggt cttaggggta cagttaaagg caggatgaca gctattctcc 2460 tgctcatctc agagcgctgc cgccccctca tgccggtcgc gcaaagaaca cagcttttaa 2520 aaaacacgtg ccttctgccc atataggtct gaaagtgatg aggaaagtaa tgcttcgcct 2580 attagcgagt ttcagctttt aaaatgatcc caagcgttgc tgagatgaga aagcgtggca 2640 tcccgggggt cctcagcccc acccgcgccc atggtgcaag tctgcaggga caggcccggg 2700 acagcactgc ccacgctgct agattttccg cagaggatcg ctgaagctgc cttcgtggga 2760 gacagaatgc ctcctccagc gagtggaaaa ggcctgctga ggaccccgct ttgctcgagc 2820 attcaaatgt gtgtctgttt tattaccctg ggttgaaaag ggacaagagc tttagccttt 2880 ttatctggcc attttatcag caactacaag tgtgttgagt ggttattatt acataggagg 2940 cttttcagtt tggggtcagt agatcagtct cttcagacac tgatgcagaa gctgggactg 3000 gtaagtaggt attatgtgct cggagcgcta ggggacagga gcaaatggag aagaaaagcg 3060 gaggctttct ccgcccggag tatcgatcgg aatccccgcc ggtacgccgc agagggccct 3120 cgccgttggg ccccgggggt ttaacaagcc cagccgctcc gcaggcggct cggccggact 3180 ctcagaccgg tgcctggaag acaccgtccc tgcccccctc ccgccaaacc tgcctcttct 3240 ctttctctca taggttatag gttccctttc tctctcattt tggccccgcc cccgggtcct 3300 gccaaacagc caagcaggcc ggggtttagg gggctcagaa tgaagaggtc tgatttggcc 3360 agcgccggca aagctcaccc ttaggcgagg tcacaacaga ggcaggtcct tcctgcccag 3420 cctgccggtg tagtcacagc caagggtggc acttgaaagg aaaagggaga aaacttcgga 3480 gaaatttaga ttgccccaac gttagatttc agagaaattg actccaaatg cacggattcg 3540 ttcggaaagg gcggctaagt ggcaggtggt tgcaaccccg cccggtcggg ccttcgcaga 3600 ggttccccaa gaccagccct tgcagggcgg ttttcagcaa cctgacaaga ggcggccaag 3660 acaaatttct gcgggttcga gcacacactc tcgggcgttg ggccccagag acctctaaac 3720 caagcacaaa caagaaggga gtgagagaac ccaggctaga acttgcacgg gcatcccact 3780 gaggaaaagc gaggcctcgg tggcaggcat gttttcttcc gacgcccgaa aatcgagccg 3840 agcgcccgac tacatttact gcagaggttt ccgcctccag tgagcccgga tcccccagcg 3900 gcctgcccgg agctggtctc cagtccccgc cgtagtccga cgcacggccc tctcctggca 3960 gcaagctccc agcggccagt ctgaagccaa ttctgttcag gcggccgagg gcccttagcc 4020 aacccaccat gatgtcgcct gggccacctg atgcccgcag cggcgggaca cggcccgggc 4080 agtgcgcagt ggctcctgct aggggcaccg cgtgcgtgct tgtctcccgc tgcgccgggg 4140 acgtccttgg gtgacacggg ccgctgggca cctcccaagc cgaggaaacg gacccccttc 4200 gcagagtctc gcgcccaccc cccaacctcc cacctcgttt ctcgctgcta gggctcccga 4260 ctcagcccac ctctcctggc ggtttagtta gggatcagag ctggagaggc tgaacgcaac 4320 ccgtgccagt acggaacaga cgatatgttt gcctgctagc tgcttggatg aataattgaa 4380 aagttcgctg cagtctgtgc ttcgtcaagt cccgggtgcc gggagaacac cttcccaaca 4440 cgcatcaggg tgggcgggag cgggcagagg aggcgggacc cgagggagga gagtgaaccc 4500 gagcaggaga agcagcccag gcagccaggc gccctcgatg cgagaggctg ggcatttatt 4560 tttattccag gctttccact gtgtggttat gtcactttct caaacaaatg tgtatatgga 4620 gggagatcga tgctgataat gtttagaaga ttaaaagagc attaatgctg gcaacaataa 4680 cgtaaacgtg tggacccaga tttcattgat ctggaacttg atccggcgcg tttccagtaa 4740 gcccgacggc gcgctcttcc cagcagagcg ctcaccagcg ccacggcccc gcggttttcc 4800 agcggtgccg cttcgccagc tctgcgcggg ttctcccgtc tgaccgcagc tcctcccccg 4860 cgaggcccca gcccgcctta cttccccgag gttttctcct cctctcgcgg ggctctctgc 4920 cctctgcacc ccctcccccg acctctgcac cacccgcccc tgtgcgcaca caccgctact 4980 tgcgcttccg gcgatccgcc tg 5002 <210> 41 <211> 150 <212> DNA <213> Homo sapiens <400> 41 aaccggagat ctgcttggtg aactgagagg agtccttagg agagcgggga cgccaggggc 60 cgggggacac ttcgctctcg ccctagggaa ggtggtcttg acgctttcta ttgaagtcaa 120 acttgaaaat atcagctgcc gctggactat 150 <210> 42 <211> 339 <212> DNA <213> Homo sapiens <400> 42 cgtgagcaga acgcccgccc tggagcagtt aggaccgaag gtctccggag agtcgccggc 60 ggtgccaggt aacgcagagg gctcgggtcg ggccccgctt ctggggcttg ggactccggg 120 cgcgcggagc cagccctctg gggcgaaatc cccgggcggc gtgcgcggtc cctctccgcg 180 ctgtgctctc ccagcaactc cctgccacct cgacgagcct accggccgct ccgagttcga 240 cttcctcgga cttagtggga gaaggggttg gaaatgggct gccgggactg ggggagctgc 300 tctctggaag cagggaagct ggggcgcacc ggggcaggt 339 <210> 43 <211> 1961 <212> DNA <213> Homo sapiens <400> 43 tagaagagga agactcctct ggccccacta ggtatcatcc gcgctctccc gctttccacc 60 tgcgccctcg cttgggccaa tctctgccgc acgtgtccat ccctgaactg cacgctatcc 120 tccacccccg gggggttcct gcgcactgaa agaccgttct ccggcaggtt ttgggatccg 180 gcgacggctg accgcgcgcc gcccccacgc ccggttccac gatgctgcaa tacagaaagt 240 ttacgtcggc cccgacccgc gcgggactgc agggtccgcc ggagcgcggc gcagaggctt 300 ttcctgcgcg ttcggccccg ggaaaggggc gggagggctg gctccgggag cgcacgggcg 360 cggcggggag ggtactcact gtgaagcacg ctgcgcccat ggatcatgtc tgtgcgttac 420 accagaggct ccgggctcca ctaattccat ttagagacgg gaagacttcc agtggcgggg 480 ggaggacagg gtcgagaggt gttaaagacg caaagcaaga aggaaataaa ggggggccga 540 gagggagacc gagaggaagg gggagctccg agcccacgct gcagccagat ccggatgagt 600 ccgtcctccg ccccgggcgg gctctcgctc tcgctggccc tcagcgccgc gcagccagca 660 gcatccccac cgtgacgctc gcatcacacc cgggcgccgg ccgccaccat ccgcgccgcc 720 gccgtcagga ccctcctccc gggcatcgtc gccgccgcgg ggtcgggagg acgcggcgcg 780 cgggaggcgg cggtcgcagg gcgagccccg ggacgccccg agccggggcc ggggccgggg 840 agagggcgca gcgaggtggg ggccagtcca gaccgacggc agcgacggag cgggcggcgg 900 cggcggcgcc ggcggcggcg gggtggctca gtccccagtc tcagacgcgc cgcgcagcag 960 gtcggagcag cctccccggg aggatgtcca gcggcagcgc tcctcgctcc agcccttggg 1020 gatcttccgc tgaggcattg aaggcaggaa gaaggggtcc gtcatcggct cgccgggctg 1080 cgcgccacct ctgctatctt gcggaaagag gagcgggtgg gtgggcgtct gggaggcggg 1140 ctggagggcg gtgcagggga gcggggcggc cggggggggg gccggggggc ggggaaggga 1200 gggaggagaa aggagccgga agagggcaga gttaccaaat gggctcctta gtcatggctt 1260 ggggctccac gaccctcctg gaagcccgga gcctgggtgg gatagcgagg ctgcgcgcgg 1320 ccggcgcccc ggggctggtg cgcggcagaa tggggccgcg gcggcggcag caaggacatc 1380 ccagccgcgc ggatctgggg gaggggcggg gagggggtga ggacccggct gggatccgcg 1440 gctcggcccg ccagggcgca gagagaggat gcagccgcaa atcccgagcc ggatcctcgt 1500 gccggacgga aggcgtggaa gcgggagggg ccttcgtgtg aaaatccctt gtggggtttg 1560 gtgtttcact ttttaaaggt tagaccttgc gggctctctg cctcccaccc cttcttttcc 1620 atccgcgtaa aggaactggg cgccccctct ccctccctcc ctggggcgca ggtttcgccg 1680 cggactccgc gctcagcttg ggagacacgg caggggcgcg ccccagggaa aggcggccgt 1740 aaaagtttcg cggttgagca ctgggcctga tgtccagtcc ccccaccaaa ttactcctgc 1800 aaagacgcgg gcttcttgca attgagcccc ccacctcgag gtatttaaaa ccaccccaag 1860 gcacacacgg acccccgttc ccccgcgcca cttcctccta caggctcgcg cggcgcgtta 1920 aagtctggga gacacgagtt gcggggaaac agcaccggaa g 1961 <210> 44 <211> 314 <212> DNA <213> Homo sapiens <400> 44 aagaaacagc tcatttcgga gctgaggaca aggcgtggga agaagacgcg tttggtttca 60 cccaggcggg tggcggcaaa gctgtgggat gcgcgctgca cactccttcc gtcatcccgt 120 tcccaccttc cacacacacc tgcgggaggt cggacatgtc ctgattgcgt gttcatcacg 180 atggcaaacc gaacatgagg agaacgccac tgacgctggg tgcgccggct ttcccagccc 240 tcgtgcataa cggggaggga gatgcagaag ttttttccaa catcggtgca aaggggaagc 300 tgaggttttc ctat 314 <210> 45 <211> 584 <212> DNA <213> Homo sapiens <400> 45 tctgtcagct gctgccatgg ggcagcggga aggccctgga gggtgcctgg gctgtgtctg 60 gtcccggcca cgcgtccctg cagcgtctga gaccttgtgg aacacacttg acccggcgct 120 gggacggggt cggcccacac gcaccgccag cccgcaggag tgaggtgcag gctgccgctg 180 gctccttagg cctcgacagc tctcttgagg tcggccctcc tcccctcccg agagctcagc 240 agccgcagac ccaggcagag agagcaaagg aggctgtggt ggcccccgac gggaacctgg 300 gtggccgggg gacacaccga ggaactttcc gccccccgac gggctctccc accgaggctc 360 aggtgctcgt gggcagcaag gggaagcccc atggccatgc cgcttccctt tcaccctcag 420 cgacgcgccc tcctgtgccc gcggggaaca agacggctct cggcggccat gcaggcggcc 480 tgtcccacga acacgatgga gacctcagac gccgtcccca ccctgtcact gtcaccatca 540 cccatcctgt cccctcacgc ctccccacat cccatcatta ctac 584 <210> 46 <211> 349 <212> DNA <213> Homo sapiens <400> 46 gaagtagaat cacagtaaat gaggagttag ggaatttagg gtagagatta aagtaatgaa 60 cagaggagga ggcctgagac agctgcagag agaccctgtg ttccctgtga ggtgaagcgt 120 ctgctgtcaa agccggttgg cgctgagaag aggtaccggg ggcagcaccc gcctcctggg 180 agagggatgg gcctgcgggc acctggggga accgcacgga cacagacgac actataaacg 240 cgggcgagac atcagggacc gggaaacaga aggacgcgcg tttcgagcag ctgcccagtg 300 ggccacaagc cccgccacgc cacagcctct tcccctcagc acgcagaga 349 <210> 47 <211> 3510 <212> DNA <213> Homo sapiens <400> 47 tactccggcg acgggaggat gttgagggaa gcctgccagg tgaagaaggg gccagcagca 60 gcacagagct tccgactttg ccttccaggc tctagactcg cgccatgcca agacgggccc 120 ctcgactttc acccctgact cccaactcca gccactggac cgagcgcgca aagaacctga 180 gaccgcttgc tctcaccgcc gcaagtcggt cgcaggacag acaccagtgg gcagcaacaa 240 aaaaagaaac cgggttccgg gacacgtgcc ggcggctgga ctaacctcag cggctgcaac 300 caaggagcgc gcacgttgcg cctgctggtg tttattagct acactggcag gcgcacaact 360 ccgcgccccg actggtggcc ccacagcgcg caccacacat ggcctcgctg ctgttggcgg 420 ggtaggcccg aaggaggcat ctacaaatgc ccgagccctt tctgatcccc acccccccgc 480 tccctgcgtc gtccgagtga cagattctac taattgaacg gttatgggtc atccttgtaa 540 ccgttggacg acataacacc acgcttcagt tcttcatgtt ttaaatacat atttaacgga 600 tggctgcaga gccagctggg aaacacgcgg attgaaaaat aatgctccag aaggcacgag 660 actggggcga aggcgagagc gggctgggct tctagcggag accgcagagg gagacatatc 720 tcagaactag gggcaataac gtgggtttct ctttgtattt gtttattttg taactttgct 780 acttgaagac caattattta ctatgctaat ttgtttgctt gtttttaaaa ccgtacttgc 840 acagtaaaag ttccccaaca acggaagtaa cccgacgttc ctcacactcc ctaggagact 900 gtgtgcgtgt gtgcccgcgc gtgcgctcac agtgtcaagt gctagcatcc gagatctgca 960 gaaacaaatg tctgaattcg aaatgtatgg gtgtgagaaa ttcagctcgg ggaagagatt 1020 agggactggg ggagacaggt ggctgcctgt actataagga accgccaacg ccagcatctg 1080 tagtccaagc agggctgctc tgtaaaggct tagcaatttt ttctgtaggc ttgctgcaca 1140 cggtctctgg cttttcccat ctgtaaaatg ggtgaatgca tccgtacctc agctacctcc 1200 gtgaggtgct tctccagttc gggcttaatt cctcatcgtc aagagttttc aggtttcaga 1260 gccagcctgc aatcggtaaa acatgtccca acgcggtcgc gagtggttcc atctcgctgt 1320 ctggcccaca gcgtggagaa gccttgccca ggcctgaaac ttctctttgc agttccagaa 1380 agcaggcgac tgggacggaa ggctctttgc taacctttta cagcggagcc ctgcttggac 1440 tacagatgcc agcgttgccc ctgccccaag gcgtgtggtg atcacaaaga cgacactgaa 1500 aatacttact atcatccggc tcccctgcta ataaatggag gggtgtttaa ctacaggcac 1560 gaccctgccc ttgtgctagc gcggttaccg tgcggaaata actcgtccct gtacccacac 1620 catcctcaac ctaaaggaga gttgtgaatt ctttcaaaac actcttctgg agtccgtccc 1680 ctccctcctt gcccgccctc tacccctcaa gtccctgccc ccagctgggg gcgctaccgg 1740 ctgccgtcgg agctgcagcc acggccatct cctagacgcg cgagtagagc accaagatag 1800 tggggacttt gtgcctgggc atcgtttaca tttggggcgc caaatgccca cgtgttgatg 1860 aaaccagtga gatgggaaca ggcggcggga aaccagacag aggaagagct agggaggaga 1920 ccccagcccc ggatcctggg tcgccagggt tttccgcgcg catcccaaaa ggtgcggctg 1980 cgtggggcat caggttagtt tgttagactc tgcagagtct ccaaaccatc ccatccccca 2040 acctgactct gtggtggccg tattttttac agaaatttga ccacgttccc tttctccctt 2100 ggtcccaagc gcgctcagcc ctccctccat cccccttgag ccgcccttct cctccccctc 2160 gcctcctcgg gtccctcctc cagtccctcc ccaagaatct cccggccacg ggcgcccatt 2220 ggttgtgcgc agggaggagg cgtgtgcccg gcctggcgag tttcattgag cggaattagc 2280 ccggatgaca tcagcttccc agccccccgg cgggcccagc tcattggcga ggcagcccct 2340 ccaggacacg cacattgttc cccgcccccg cccccgccac cgctgccgcc gtcgccgctg 2400 ccaccgggct ataaaaaccg gccgagcccc taaaggtgcg gatgcttatt atagatcgac 2460 gcgacaccag cgcccggtgc caggttctcc cctgaggctt ttcggagcga gctcctcaaa 2520 tcgcatccag agtaagtgtc cccgccccac agcagccgca gcctagatcc cagggacaga 2580 ctctcctcaa ctcggctgtg acccagaatg ctccgataca gggggtctgg atccctactc 2640 tgcgggccat ttctccagag cgactttgct cttctgtcct ccccacactc accgctgcat 2700 ctccctcacc aaaagcgaga agtcggagcg acaacagctc tttctgccca agccccagtc 2760 agctggtgag ctccccgtgg tctccagatg cagcacatgg actctgggcc ccgcgccggc 2820 tctgggtgca tgtgcgtgtg cgtgtgtttg ctgcgtggtg tcgatggaga taaggtggat 2880 ccgtttgagg aaccaaatca ttagttctct atctagatct ccattctccc caaagaaagg 2940 ccctcacttc ccactcgttt attccagccc gggggctcag ttttcccaca cctaactgaa 3000 agcccgaagc ctctagaatg ccacccgcac cccgagggtc accaacgctc cctgaaataa 3060 cctgttgcat gagagcagag gggagataga gagagcttaa ttataggtac ccgcgtgcag 3120 ctaaaaggag ggccagagat agtagcgagg gggacgagga gccacgggcc acctgtgccg 3180 ggaccccgcg ctgtggtact gcggtgcagg cgggagcagc ttttctgtct ctcactgact 3240 cactctctct ctctctccct ctctctctct ctcattctct ctcttttctc ctcctctcct 3300 ggaagttttc gggtccgagg gaaggaggac cctgcgaaag ctgcgacgac tatcttcccc 3360 tggggccatg gactcggacg ccagcctggt gtccagccgc ccgtcgtcgc cagagcccga 3420 tgaccttttt ctgccggccc ggagtaaggg cagcagcggc agcgccttca ctgggggcac 3480 cgtgtcctcg tccaccccga gtgactgccc 3510 <210> 48 <211> 333 <212> DNA <213> Homo sapiens <400> 48 ttaattcgaa aatggcagac agagctgagc gctgccgttc ttttcaggat tgaaaatgtg 60 ccagtgggcc aggggcgctg ggacccgcgg tgcggaagac tcggaacagg aagaaatagt 120 ggcgcgctgg gtgggctgcc ccgccgccca cgccggttgc cgctggtgac agtggctgcc 180 cggccaggca cctccgagca gcaggtctga gcgtttttgg cgtcccaagc gttccgggcc 240 gcgtcttcca gagcctctgc tcccagcggg gtcgctgcgg cctggcccga aggatttgac 300 tctttgctgg gaggcgcgct gctcagggtt ctg 333 <210> 49 <211> 385 <212> DNA <213> Homo sapiens <400> 49 ccggtcccca gtttggaaaa aggcgcaaga agcgggcttt tcagggaccc cggggagaac 60 acgagggctc cgacgcggga gaaggattga agcgtgcaga ggcgccccaa attgcgacaa 120 tttactggga tccttttgtg gggaaaggag gcttagaggc tcaagctata ggctgtccta 180 gagcaactag gcgagaacct ggccccaaac tccctcctta cgccctggca caggttcccg 240 gcgactggtg ttcccaaggg agccccctga gcctaccgcc cttgcagggg gtcgtgctgc 300 ggcttctggg tcataaacgc cgaggtcggg ggtggcggag ctgtagaggc tgcccgcgca 360 gaaagctcca ggatcccaat atgtg 385 <210> 50 <211> 105 <212> DNA <213> Homo sapiens <400> 50 gcgcaggtcc ccccagtccc cgagggagtg cgcccgacgg aaacgcccct agcccgcggg 60 cctcgctttc ctctcccggg ttcctgggtc acttcccgct gtctc 105 <210> 51 <211> 147 <212> DNA <213> Homo sapiens <400> 51 ttccctcgcg gctttggaaa gggggtgcaa atgcaccctt ctgcgggccc gctacccgct 60 gcaacacctg tgtttccttt ctgggcacct tctaggtttc tagatattgc tgtgaatacg 120 gtcctccgct gtacagttga aaacaaa 147 <210> 52 <211> 365 <212> DNA <213> Homo sapiens <400> 52 tgggaattta ggtcgggcac tgccgatatg tcgccttcca caaggcgggc ccgggcctct 60 gctgaccgtg caccggtcct ggggctgggt aattctgcag cagcagcgca gcccatgccg 120 gggaatttgc gggcagagga gacagtgagg cccgcgttct gtgcgggaac tcccgagctc 180 acagagccca agaccacacg gctgcatctg cttggctgac tgggccaggc ccacgcgtag 240 taacccggac gtctctctct cacagtcccc ttgcgtctgg ccagggagct gccaggctgc 300 accccgcggt ggggatcggg agaggggcag tgtcgcccat ccccggaagg ctgagcctgg 360 tgcag 365 <210> 53 <211> 418 <212> DNA <213> Homo sapiens <400> 53 cggttttctc ctggaggact gtgttcagac agatactggt ttccttatcc gcaggtgtgc 60 gcggcgctcg caagtggtca gcataacgcc gggcgaattc ggaaagcccg tgcgtccgtg 120 gacgacccac ttggaaggag ttgggagaag tccttgttcc cacgcgcgga cgcttccctc 180 cgtgtgtcct tcgagccaca aaaagcccag accctaaccc gctcctttct cccgccgcgt 240 ccatgcagaa ctccgccgtt cctgggaggg gaagcccgcg aggcgtcggg agaggcacgt 300 cctccgtgag caaagagctc ctccgagcgc gcggcgggga cgctgggccg acaggggacc 360 gcgggggcag ggcggagagg acccgccctc gagtcggccc agccctaaca ctcaggac 418 <210> 54 <211> 906 <212> DNA <213> Homo sapiens <400> 54 agggaatcgg gctgaccagt cctaaggtcc cacgctcccc tgacctcagg gcccagagcc 60 tcgcattacc ccgagcagtg cgttggttac tctccctgga aagccgcccc cgccggggca 120 agtgggagtt gctgcactgc ggtctttgga ggcctaggtc gcccagagta ggcggagccc 180 tgtatccctc ctggagccgg cctgcggtga ggtcggtacc cagtacttag ggagggagga 240 cgcgcttggt gctcagggta ggctgggccg ctgctagctc ttgatttagt ctcatgtccg 300 cctttgtgcc ggcctctccg atttgtgggt ccttccaaga aagagtcctc tagggcagct 360 agggtcgtct cttgggtctg gcgaggcggc aggccttctt cggacctatc cccagaggtg 420 taacggagac tttctccact gcagggcggc ctggggcggg catctgccag gcgagggagc 480 tgccctgccg ccgagattgt ggggaaacgg cgtggaagac accccatcgg agggcaccca 540 atctgcctct gcactcgatt ccatcctgca acccaggaga aaccatttcc gagttccagc 600 cgcagaggca cccgcggagt tgccaaaaga gactcccgcg aggtcgctcg gaaccttgac 660 cctgacacct ggacgcgagg tctttcagga ccagtctcgg ctcggtagcc tggtccccga 720 ccaccgcgac caggagttcc ttcttccctt cctgctcacc agccggccgc cggcagcggc 780 tccaggaagg agcaccaacc cgcgctgggg gcggaggttc aggcggcagg aatggagagg 840 ctgatcctcc tctagccccg gcgcattcac ttaggtgcgg gagccctgag gttcagcctg 900 actttc 906 <210> 55 <211> 860 <212> DNA <213> Homo sapiens <400> 55 cactacggat ctgcctggac tggttcagat gcgtcgttta aagggggggg ctggcactcc 60 agagaggagg gggcgctgca ggttaattga tagccacgga agcacctagg cgccccatgc 120 gcggagccgg agccgccagc tcagtctgac ccctgtcttt tctctcctct tccctctccc 180 acccctcact ccgggaaagc gagggccgag gtaggggcag atagatcacc agacaggcgg 240 agaaggacag gagtacagat ggagggacca ggacacagaa tgcaaaagac tggcaggtga 300 gaagaaggga gaaacagagg gagagagaaa gggagaaaca gagcagaggc ggccgccggc 360 ccggccgccc tgagtccgat ttccctcctt ccctgaccct tcagtttcac tgcaaatcca 420 cagaagcagg tttgcgagct cgaatacctt tgctccactg ccacacgcag caccgggact 480 gggcgtctgg agcttaagtc tgggggtctg agcctgggac cggcaaatcc gcgcagcgca 540 tcgcgcccag tctcggagac tgcaaccacc gccaaggagt acgcgcggca ggaaacttct 600 gcggcccaat ttcttcccca gctttggcat ctccgaaggc acgtacccgc cctcggcaca 660 agctctctcg tcttccactt cgacctcgag gtggagaaag aggctggcaa gggctgtgcg 720 cgtcgctggt gtggggaggg cagcaggctg cccctccccg cttctgcagc gagttttccc 780 agccaggaaa agggagggag ctgtttcagg aatttcagtg ccttcaccta gcgactgaca 840 caagtcgtgt gtataggaag 860 <210> 56 <211> 452 <212> DNA <213> Homo sapiens <400> 56 ggagcctgaa gtcagaaaag atggggcctc gttactcact ttctagccca gcccctggcc 60 ctgggtcccg cagagccgtc atcgcaggct cctgcccagc ctctggggtc gggtgagcaa 120 ggtgttctct tcggaagcgg gaagggctgc gggtcgggga cgtcccttgg ctgccacccc 180 tgattctgca tccttttcgc tcgaatccct gcgctaggca tcctccccga tcccccaaaa 240 gcccaagcac tgggtctggg ttgaggaagg gaacgggtgc ccaggccgga cagaggctga 300 aaggaggcct caaggttcct ctttgctaca aagtggagaa gttgctctac tctggagggc 360 agtggccttt tccaaacttt tccacttagg tccgtaagaa aagcaattca tacacgatca 420 gcgctttcgg tgcgaggatg gaaagaaact tc 452 <210> 57 <211> 1992 <212> DNA <213> Homo sapiens <400> 57 ttttcctgtt acagagctga gcccactcat gtggtgccaa gtagcgacta tctctcggcc 60 acctccaccc agagcaatgt gggcgccccc agcgggtggg agcgattgcc gagcggcgca 120 agggcgttta acgcctaacc ccctcctcct gggttgccaa gccgctaggt cgccgtttcc 180 aacgtggctg cgcgggactg aagtccgacg actcctcgtc ctcagtagga gacacacctc 240 ccactgcccc cagccacgcg agctatgggc agaatcgggg caacggtaat atctggatgg 300 ggcaggctcc cctgaggctg tgcttaagaa aaaaggaatc tggagtagcc tgaggggccc 360 cacgaggggg cctcctttgc gatcgtctcc cagccttagg ccaaggctac ggaggcaggc 420 ggccgagtgt tggcgcccag cccggccgag gactggatgg aggacgagaa gcagcctgcc 480 tctgggcgac agctgcggac gcagcctcgc cgcctcgccg cctcagcctc ggtcccagcg 540 tctctaaagc cgcgcccatt ttacagatgc agggcaggga gacaagaggc atctccgggg 600 gccgagtaga atgatggcgc gggttctccc ggcgccctga tttcgaggct gcgcccgggg 660 ccctacatgc aggcggggag gcctgggccg aaggcgtctg caaggagggg cgagtctgcc 720 cggtccgggc agggagtgag gccacagtca gttctcccta ggaggccgcg cagcgggtag 780 ggtatgggac tgggggacgc aacggggacc tggccgaatc agagccctca gcagagaacg 840 ccgaaaactc tggggccggc cgctcgcttc ccgctagtgg gaatggtttc cggtcatccg 900 ttcccagtcc agccccgggt agggagctct gatttgcaat gcacagcact tgcgaggttc 960 gaatgccccc gcaatttgca gatggaaata ctaagcctag gccgggcgtg gtggctcaag 1020 cctatcatct cagccctttg ggaggccaag ccgggaggat tgtttgagcc caagaattca 1080 aaaccagcct gagcaacata gcgaccccgt ctctacaaaa taaaataaaa taaattatcc 1140 gggcgtggtg gcacgcgcct gtggttccag ctactccgga ggctgaggtg ggaggatcgc 1200 ttgagtccgg gaggtcgagg ctacagtgag ccgtgatcgc accactgcac tccagcctgg 1260 gcgacagagt gagaccttgt ctcaaaaaag gaaaaaaaga aaaagaaagt aagcttcaaa 1320 gaagctctga taatagttct gggtcgtgca gcggtggcgg ccccgcgctc tcgcccctaa 1380 agcaagcgct ctttgtactg ggtggaggag ctttgagtag tgagggtgga gatgcagctt 1440 cggggtggcg cagccaccct gacactaggc ccggggtcgc agtgggacag aagagtctgc 1500 cgctctgact tgggctctga gttccaaggg cgcccggcac ttctagcctc ccaggcttgc 1560 gcgctggcgc ctttgccatc cgtgccgaag tggggagacc tagccgcgac caccacgagc 1620 gcagcggtga cacccagagg tcccaccggg cccctgggca gggtaacctt agcctgtccg 1680 cttcggcagc tttgcgaaga gtggcgcgca gctagggctg aggctcttgc ggacctgcgg 1740 tcgaagcagg cggctgagcc agttcgatcg ccaaggcctg ggctgccgac agtggtgcgc 1800 gctctgttcc gccgcggccg ggccaggcgc tctggaatag cgatgggggg acacggcctc 1860 caactttctg cagagaccat cgggcagctc cgggcctaag cagcgacctc accgaaggtt 1920 cctgggaacc tttgccaaaa tcccagcctc tgcctcggtc cagctaaacc gtgtgtaaac 1980 aagtgcacca ag 1992 <210> 58 <211> 448 <212> DNA <213> Homo sapiens <400> 58 ataaaggacc gggtaatttc gcggaatgcg gattttgaga caggcccaga cggcggcgga 60 ttccctgtgt cccccaactg gggcgatctc gtgaacacac ctgcgtccca ccccgatcct 120 aggttggggg gaaagggtat gggaaccctg agcccagagc gcgccccgct ctttcctttg 180 ctccccggct tccctggcca gccccctccc ggctggtttc ctcgctcact cggcgcctgg 240 cgtttcgggc gtctggagat caccgcgtgt ctggcacccc aacgtctagt ctccccgcag 300 gttgaccgcg gcgcctggag ccgggaatag gggtggggag tccggagaac caaacccgag 360 cctgaagttg ccattcgggt gactcccgag aaagcccggg agcattttgg ccaatgcggg 420 tttttacctg aacttcagca tcttcacc 448 <210> 59 <211> 395 <212> DNA <213> Homo sapiens <400> 59 aattggaaaa ccctggtatt gtgcctgttt gggggaagaa aacgtcaata aaaattaatt 60 gatgagttgg cagggcgggc ggtgcgggtt cgcggcgagg cgcagggtgt catggcaaat 120 gttacggctc agattaagcg attgttaatt aaaaagcgac ggtaattaat actcgctacg 180 ccatatgggc ccgtgaaaag gcacaaaagg tttctccgca tgtggggttc cccttctctt 240 ttctccttcc acaaaagcac cccagcccgt gggtcccccc tttggcccca aggtaggtgg 300 aactcgtcac ttccggccag ggaggggatg gggcggtctc cggcgagttc caagggcgtc 360 cctcgttgcg cactcgcccg cccaggttct ttgaa 395 <210> 60 <211> 491 <212> DNA <213> Homo sapiens <400> 60 gggaagcgat cgtctcctct gtcaactcgc gcctgggcac ttagcccctc ccgtttcagg 60 gcgccgcctc cccggatggc aaacactata aagtggcggc gaataaggtt cctcctgctg 120 ctctcggttt agtccaagat cagcgatatc acgcgtcccc cggagcatcg cgtgcaggag 180 ccatggcgcg ggagctatac cacgaagagt tcgcccgggc gggcaagcag gcggggctgc 240 aggtctggag gattgagaag ctggagctgg tgcccgtgcc ccagagcgct cacggcgact 300 tctacgtcgg ggatgcctac ctggtgctgc acacggccaa gacgagccga ggcttcacct 360 accacctgca cttctggctc ggtaagggac ggcgggcggc gggaccccga cgcaccaagg 420 ccggcgaggg gagggcgtag gggtctgaga tttgcaggcg tgggagtaaa ggggaccgca 480 aactgagcta g 491 <210> 61 <211> 1284 <212> DNA <213> Homo sapiens <400> 61 ctcaggggcg ggaagtggcg ggtgggagtc acccaagcgt gactgcccga ggcccctcct 60 gccgcggcga ggaagctcca taaaagccct gtcgcgaccc gctctctgca ccccatccgc 120 tggctctcac ccctcggaga cgctcgcccg acagcatagt acttgccgcc cagccacgcc 180 cgcgcgccag ccaccgtgag tgctacgacc cgtctgtcta ggggtgggag cgaacggggc 240 gcccgcgaac ttgctagaga cgcagcctcc cgctctgtgg agccctgggg ccctgggatg 300 atcgcgctcc actccccagc ggactatgcc ggctccgcgc cccgacgcgg accagccctc 360 ttggcggcta aattccactt gttcctctgc tcccctctga ttgtccacgg cccttctccc 420 gggcccttcc cgctgggcgg ttcttctgag ttacctttta gcagatatgg agggagaacc 480 cgggaccgct atcccaaggc agctggcggt ctccctgcgg gtcgccgcct tgaggcccag 540 gaagcggtgc gcggtaggaa ggtttccccg gcagcgccat cgagtgagga atccctggag 600 ctctagagcc ccgcgccctg ccacctccct ggattcttgg gctccaaatc tctttggagc 660 aattctggcc cagggagcaa ttctctttcc ccttccccac cgcagtcgtc accccgaggt 720 gatctctgct gtcagcgttg atcccctgaa gctaggcaga ccagaagtaa cagagaagaa 780 acttttcttc ccagacaaga gtttgggcaa gaagggagaa aagtgaccca gcaggaagaa 840 cttccaattc ggttttgaat gctaaactgg cggggccccc accttgcact ctcgccgcgc 900 gcttcttggt ccctgagact tcgaacgaag ttgcgcgaag ttttcaggtg gagcagaggg 960 gcaggtcccg accggacggc gcccggagcc cgcaaggtgg tgctagccac tcctgggttc 1020 tctctgcggg actgggacga gagcggattg ggggtcgcgt gtggtagcag gaggaggagc 1080 gcggggggca gaggagggag gtgctgcgcg tgggtgctct gaatccccaa gcccgtccgt 1140 tgagccttct gtgcctgcag atgctaggta acaagcgact ggggctgtcc ggactgaccc 1200 tcgccctgtc cctgctcgtg tgcctgggtg cgctggccga ggcgtacccc tccaagccgg 1260 acaacccggg cgaggacgca ccag 1284 <210> 62 <211> 554 <212> DNA <213> Homo sapiens <400> 62 tggagaacct tgggctctgt ggcctcaaag gtaggggtga tttcgagggg ccggcacctc 60 acagggcagg ttccaccgcg gaaacgcagt catcgcccag cgaccctgct cctggccctc 120 agcctccccc caggtttctt tttctcttga atcaagccga ggtgcgccaa tggccttcct 180 tgggtcggat ccggggggcc agggccagct tacctgcttt caccgagcag tggatatgtg 240 ccttggactc gtagtacacc cagtcgaagc cggcctccac cgccaggcgg gccagcatgc 300 cgtacttgct gcggtcgcgg tcagacgtgg tgatgtccac tgcgcggccc tcgtagtgca 360 gagactcctc tgagtggtgg ccatcttcgt cccagccctc ggtcacccgc agtttcactc 420 ctggccactg gttcatcacc gagatggcca aagcgttcaa cttgtcctta cacctctgcg 480 aagacaaggg gacccccacc gacggacacg ttagcctggg caaccgccac ccctcccggc 540 ccctccatca gcct 554 <210> 63 <211> 772 <212> DNA <213> Homo sapiens <400> 63 tctcacgacc catccgttaa cccaccgttc ccaggagctc cgaggcgcag cggcgacaga 60 ggttcgcccc ggcctgctag cattggcatt gcggttgact gagcttcgcc taacaggctt 120 ggggagggtg ggctgggctg ggctgggctg ggctgggtgc tgcccggctg tccgcctttc 180 gttttcctgg gaccgaggag tcttccgctc cgtatctgcc tagagtctga atccgacttt 240 ctttcctttg ggcacgcgct cgccagtgga gcacttcttg ttctggcccc gggctgatct 300 gcacgcggac ttgagcaggt gccaaggtgc cacgcagtcc cctcacggct ttcggggggt 360 cttggagtcg ggtggggagg gagacttagg tgtggtaacc tgcgcaggtg ccaaagggca 420 gaaggagcag ccttggatta tagtcacggt ctctccctct cttccctgcc atttttaggg 480 ctttctctac gtgctgttgt ctcactgggt ttttgtcgga gccccacgcc ctccggcctc 540 tgattcctgg aagaaagggt tggtcccctc agcaccccca gcatcccgga aaatggggag 600 caaggctctg ccagcgccca tcccgctcca cccgtcgctg cagctcacca attactcctt 660 cctgcaggcc gtgaacacct tcccggccac ggtggaccac ctgcagggcc tgtacggtct 720 cagcgcggta cagaccatgc acatgaacca ctggacgctg gggtatccca at 772 <210> 64 <211> 1362 <212> DNA <213> Homo sapiens <400> 64 tggtttcctt tcgcttctcg cctcccaaac acctccagca agtcggaggg cgcgaacgcg 60 gagccagaaa cccttcccca aagtttctcc cgccaggtac ctaattgaat catccatagg 120 atgacaaatc agccagggcc aagatttcca gacacttgag tgacttcccg gtccccgagg 180 tgacttgtca gctccagtga gtaacttgga actgtcgctc ggggcaaggt gtgtgtctag 240 gagagagccg gcggctcact cacgctttcc agagagcgac ccgggccgac ttcaaaatac 300 acacagggtc atttataggg actggagccg cgcgcaggac aacgtctccg agactgagac 360 attttccaaa cagtgctgac attttgtcgg gccccataaa aaatgtaaac gcgaggtgac 420 gaacccggcg gggagggttc gtgtctggct gtgtctgcgt cctggcggcg tgggaggtta 480 tagttccaga cctggcggct gcggatcgcc gggccggtac ccgcgaggag tgtaggtacc 540 ctcagcccga ccacctcccg caatcatggg gacaccggct tggatgagac acaggcgtgg 600 aaaacagcct tcgtgaaact ccacaaacac gtggaacttg aaaagacaac tacagccccg 660 cgtgtgcgcg agagacctca cgtcacccca tcagttccca cttcgccaaa gtttcccttc 720 agtggggact ccagagtggt gcgccccatg cccgtgcgtc ctgtaacgtg ccctgattgt 780 gtacccctct gcccgctcta cttgaaatga aaacacaaaa actgttccga attagcgcaa 840 ctttaaagcc ccgttatctg tcttctacac tgggcgctct taggccactg acagaaacat 900 ggtttgaacc ctaattgttg ctatcagtct cagtcagcgc aggtctctca gtgacctgtg 960 acgccgggag ttgaggtgcg cgtatcctta aacccgcgcg aacgccaccg gctcagcgta 1020 gaaaactatt tgtaatccct agtttgcgtc tctgagcttt aactccccca cactctcaag 1080 cgcccggttt ctcctcgtct ctcgcctgcg agcaaagttc ctatggcatc cacttaccag 1140 gtaaccggga tttccacaac aaagcccggc gtgcgggtcc cttcccccgg ccggccagcg 1200 cgagtgacag cgggcggccg gcgctggcga ggagtaactt ggggctccag cccttcagag 1260 cgctccgcgg gctgtgcctc cttcggaaat gaaaaccccc atccaaacgg ggggacggag 1320 cgcggaaacc cggcccaagt gccgtgtgtg cgcgcgcgtc tg 1362 <210> 65 <211> 476 <212> DNA <213> Homo sapiens <400> 65 gaaagccatc cttaccattc ccctcaccct ccgccctctg atcgcccacc cgccgaaagg 60 gtttctaaaa atagcccagg gcttcaaggc cgcgcttctg tgaagtgtgg agcgagcggg 120 cacgtagcgg tctctgccag gtggctggag ccctggaagc gagaaggcgc ttcctccctg 180 catttccacc tcaccccacc cccggctcat ttttctaaga aaaagttttt gcggttccct 240 ttgcctccta cccccgctgc cgcgcggggt ctgggtgcag acccctgcca ggttccgcag 300 tgtgcagcgg cggctgctgc gctctcccag cctcggcgag ggttaaaggc gtccggagca 360 ggcagagcgc cgcgcgccag tctattttta cttgcttccc ccgccgctcc gcgctccccc 420 ttctcagcag ttgcacatgc cagctctgct gaaggcatca atgaaaacag cagtag 476 <210> 66 <211> 300 <212> DNA <213> Homo sapiens <400> 66 atcgaaaatg tcgacatctt gctaatggtc tgcaaacttc cgccaattat gactgacctc 60 ccagactcgg ccccaggagg ctcgtattag gcagggaggc cgccgtaatt ctgggatcaa 120 aagcgggaag gtgcgaactc ctctttgtct ctgcgtgccc ggcgcgcccc cctcccggtg 180 ggtgataaac ccactctggc gccggccatg cgctgggtga ttaatttgcg aacaaacaaa 240 agcggcctgg tggccactgc attcgggtta aacattggcc agcgtgttcc gaaggcttgt 300 <210> 67 <211> 1246 <212> DNA <213> Homo sapiens <400> 67 atcaacatcg tggctttggt cttttccatc atggtgagtg aatcacggcc agaggcagcc 60 tgggaggaga gacccgggcg gctttgagcc cctgcagggg agtccgcgcg ctctctgcgg 120 ctcccttcct cacggcccgg cccgcgctag gtgttctttg tcctcgcacc tcctcctcac 180 ctttctcggg ctctcagagc tctccccgca atcatcagca cctcctctgc actcctcgtg 240 gtactcagag ccctgatcaa gcttccccca ggctagcttt cctcttcttt ccagctccca 300 gggtgcgttt cctctccaac ccggggaagt tcttccgtgg actttgctga ctcctctgac 360 cttcctaggc acttgcccgg ggcttctcaa ccctcttttc tagagcccca gtgcgcgcca 420 ccctagcgag cgcagtaagc tcataccccg agcatgcagg ctctacgttc ctttccctgc 480 cgctccgggg gctcctgctc tccagcgccc aggactgtct ctatctcagc ctgtgctccc 540 ttctctcttt gctgcgccca agggcaccgc ttccgccact ctccgggggg tccccaggcg 600 attcctgatg ccccctcctt gatcccgttt ccgcgctttg gcacggcacg ctctgtccag 660 gcaacagttt cctctcgctt cttcctacac ccaacttcct ctccttgcct ccctccggcg 720 cccccttttt aacgcgcccg aggctggctc acacccacta cctctttagg cctttcttag 780 gctccccgtg tgcccccctc accagcaaag tgggtgcgcc tctcttactc tttctaccca 840 gcgcgtcgta gttcctcccc gtttgctgcg cactggccct aacctctctt ctcttggtgt 900 cccccagagc tcccaggcgc ccctccaccg ctctgtcctg cgcccggggc tctcccggga 960 atgaactagg ggattccacg caacgtgcgg ctccgcccgc cctctgcgct cagacctccc 1020 gagctgcccg cctctctagg agtggccgct ggggcctcta gtccgccctt ccggagctca 1080 gctccctagc cctcttcaac cctggtagga acacccgagc gaaccccacc aggagggcga 1140 cgagcgcctg ctaggccctc gccttattga ctgcagcagc tggcccgggg gtggcggcgg 1200 ggtgaggttc gtaccggcac tgtcccggga caacccttgc agttgc 1246 <210> 68 <211> 984 <212> DNA <213> Homo sapiens <400> 68 acaaataaaa caccctctag cttcccctag actttgttta actggccggg tctccagaag 60 gaacgctggg gatgggatgg gtggagagag ggagcggctc aaggacttta gtgaggagca 120 ggcgagaagg agcacgttca ggcgtcaaga ccgatttctc cccctgcttc gggagacttt 180 tgaacgctcg gagaggcccg gcatctcacc actttacttg gccgtagggg cctccggcac 240 ggcaggaatg agggaggggg tccgattgga cagtgacggt ttggggccgt tcggctatgt 300 tcagggacca tatggtttgg ggacagcccc agtagttagt aggggacggg tgcgttcgcc 360 cagtccccgg atgcgtaggg aggcccagtg gcaggcagct gtcccaagca gcgggtgcgc 420 gtccctgcgc gctgtgtgtt cattttgcag agccagcctt cggggaggtg aaccagctgg 480 gaggagtgtt cgtgaacggg aggccgctgc ccaacgccat ccggcttcgc atcgtggaac 540 tggcccaact gggcatccga ccgtgtgaca tcagccgcca gctacgggtc tcgcacggct 600 gcgtcagcaa gatcctggcg cgatacaacg agacgggctc gatcttgcca ggagccatcg 660 ggggcagcaa gccccgggtc actaccccca ccgtggtgaa acacatccgg acctacaagc 720 agagagaccc cggcatcttc gcctgggaga tccgggaccg cctgctggcg gacggcgtgt 780 gcgacaagta caatgtgccc tccgtgagct ccatcagccg cattctgcgc aacaagatcg 840 gcaacttggc ccagcagggt cattacgact catacaagca gcaccagccg acgccgcagc 900 cagcgctgcc ctacaaccac atctactcgt accccagccc tatcacggcg gcggccgcca 960 aggtgcccac gccacccggg gtgc 984 <210> 69 <211> 545 <212> DNA <213> Homo sapiens <400> 69 aggaggcgca acgcgctgcc agggcggctt tatcctgccg ccacagggcg gggaccagcc 60 cggcagccgg gtgtccagcg ccgctcacgt gcctcgcctg gagcttagct ctcagactcc 120 gaagagggcg actgagactt gggcctggga gttggcttcg gggtacccaa ggcgacgaca 180 gctgagttgt accacgaagc tcaggccgag gcctcctccc ttgtctggcc ttcgaatcca 240 tactggcagc ctctcctctc aggcactccg cgggccgggc cactaggccc cctgctcctg 300 gagctgcgct atgatccggg tcttgagatg cgcgcgattc tctctgaacc ggtggagagg 360 aggctctgcc ccgcgcggag cgaggacagc ggcgcccgag cttcccgcgc ctctccaggg 420 cccaatggca agaacagcct ccgaagtgcg cggatgacag gaaaagatct tcagttcttc 480 tgccgctaga gaagtgcggg atacaagcct ctattggatc cacaacctgg agtcctgcct 540 tcgga 545 <210> 70 <211> 1533 <212> DNA <213> Homo sapiens <400> 70 atctgcgtgc ccttttctgg gcgagccctg ggagatccag ggagaactgg gcgctccaga 60 tggtgtatgt ctgtaccttc acagcaaggc ttcccttgga tttgaggctt cctattttgt 120 ctgggatcgg ggtttctcct tgtcccagtg gcagccccgc gttgcgggtt ccgggcgctg 180 cgcggagccc aaggctgcat ggcagtgtgc agcgcccgcc agtcgggctg gtgggttgtg 240 cactccgtcg gcagctgcag aaaggtggga gtgcaggtct tgcctttcct caccgggcgg 300 ttggcttcca gcaccgaggc tgacctatcg tggcaagttt gcggcccccg cagatcccca 360 gtggagaaag agggctcttc cgatgcgatc gagtgtgcgc ctccccgcaa agcaatgcag 420 accctaaatc actcaaggcc tggagctcca gtctcaaagg tggcagaaaa ggccagacct 480 aactcgagca cctactgcct tctgcttgcc ccgcagagcc ttcagggact gactgggacg 540 cccctggtgg cgggcagtcc catccgccat gagaacgccg tgcagggcag cgcagtggag 600 gtgcagacgt accagccgcc gtggaaggcg ctcagcgagt ttgccctcca gagcgacctg 660 gaccaacccg ccttccaaca gctggtgagg ccctgcccta cccgccccga cctcgggact 720 ctgcgggttg gggatttagc cacttagcct ggcagagagg ggagggggtg gccttgggct 780 gaggggctgg gtacagccct aggcggtggg ggagggggaa cagtggcggg ctctgaaacc 840 tcacctcggc ccattacgcg ccctaaacca ggtctccctg gattaaagtg ctcacaagag 900 aggtcgcagg attaaccaac ccgctccccc gccctaatcc ccccctcgtg cgcctgggga 960 cctggcctcc ttctccgcag ggcttgctct cagctggcgg ccggtcccca agggacactt 1020 tccgactcgg agcacgcggc cctggagcac cagctcgcgt gcctcttcac ctgcctcttc 1080 ccggtgtttc cgccgcccca ggtctccttc tccgagtccg gctccctagg caactcctcc 1140 ggcagcgacg tgacctccct gtcctcgcag ctcccggaca cccccaacag tatggtgccg 1200 agtcccgtgg agacgtgagg gggacccctc cctgccagcc cgcggacctc gcatgctccc 1260 tgcatgagac tcacccatgc tcaggccatt ccagttccga aagctctctc gccttcgtaa 1320 ttattctatt gttatttatg agagagtacc gagagacacg gtctggacag cccaaggcgc 1380 caggatgcaa cctgctttca ccagactgca gacccctgct ccgaggactc ttagtttttc 1440 aaaaccagaa tctgggactt accagggtta gctctgccct ctcctctcct ctctacgtgg 1500 ccgccgctct gtctctccac gccccacctg tgt 1533 <210> 71 <211> 702 <212> DNA <213> Homo sapiens <400> 71 aggtctcttc agactgccca ttctccgggc ctcgctgaat gcgggggctc tatccacagc 60 gcgcggggcc gagctcaggc aggctggggc gaagatctga ttctttcctt cccgccgcca 120 aaccgaatta atcagtttct tcaacctgag ttactaagaa agaaaggtcc ttccaaataa 180 aactgaaaat cactgcgaat gacaatacta tactacaagt tcgttttggg gccggtgggt 240 gggatggagg agaaagggca cggataatcc cggagggccg cggagtgagg aggactatgg 300 tcgcggtgga atctctgttc cgctggcaca tccgcgcagg tgcggctctg agtgctggct 360 cggggttaca gacctcggca tccggctgca ggggcagaca gagacctcct ctgctagggc 420 gtgcggtagg catcgtatgg agcccagaga ctgccgagag cactgcgcac tcaccaagtg 480 ttaggggtgc ccgtgataga ccgccaggga aggggctggt tcggagggaa ttcccgctac 540 cgggaaggtc ggaactcggg gtgatcaaac aaggaatgca tctcacctcc gtgggtgctt 600 gtgctgcgca aggaattatt accggagcgg ttgcgatggc ctttgcccgg cgacccaaga 660 agagtaagca aactaccgtc cacccagcgg atcaggtcca at 702 <210> 72 <211> 3180 <212> DNA <213> Homo sapiens <400> 72 gatgtcctgt ttctagcagc ctccagagcc aagctaggcg agaggcgtag gaggcagaga 60 gagcgggcgc gggaggccag ggtccgcctg ggggcctgag gggacttcgt ggggtcccgg 120 gagtggccta gaaacaggga gctgggaggg ccgggaagag cttgaggctg agcgggggac 180 gaacgggcag cgcaaagggg agatgaacgg aatggccgag gagccacgca ttcgccttgt 240 gtccgcggac ccttgttccc gacaggcgac caagccaagg ccctccggac tgacgcggcc 300 tgagcagcag cgagtgtgaa gtttggcacc tccggcggcg agacggcgcg ttctggcgcg 360 cggctcctgc gtccggctgg tggagctgct gcgccctatg cggcctgccg agggcgccgc 420 cgagggcccg cgagctccgt ggggtcgggg tggggggacc cgggagcgga cagcgcggcc 480 cgaggggcag gggcaggggc gcgcctggcc tggggtgtgt ctgggccccg gctccgggct 540 cttgaaggac cgcgagcagg aggcttgcgc aatcccttgg ctgagcgtcc acggagaaag 600 aaaaagagca aaagcagagc gagagtggag cgagggatgg gggcgggcaa agagccatcc 660 gggtctccac caccgccctg acacgcgacc cggctgtctg ttggggaccg cacgggggct 720 cgggcgagca ggggagggag gagcctgcgc ggggctcgtg ttcgcccagg aatcccggag 780 aagctcgaag acggtctggt gttgaacgca cacgtggact ccatttcatt accaccttgc 840 agctcttgcg ccacggaggc tgctgctgcc cggcggctgc tacccaccga gacccacgtg 900 gcccctcccc aggggtgtag gggtgacggt tgtcttctgg tgacagcaga ggtgttgggt 960 ttgcgactga tctctaacga gcttgaggcg caaacctagg attccctgag tgttggggtg 1020 cggcgggggg gcaagcaagg tgggacgacg cctgcctggt ttccctgact agttgcgggg 1080 ggtgggggcc ggctctcagg ggccaccaga agctgggtgg gtgtacagga aaatattttt 1140 ctcctgccgt gtttggcttt ttcctggcat ttttgcccag ggcgaagaac tgtcgcgcgg 1200 ggcagctcca ccgcggaggg agaggggtcg cgaggctggc gcgggaagcg ctgtaggtgg 1260 cagtcatccg tccacgccgc acaggccgtc tgcgccgtcg gaccatcggg aggtctgcag 1320 caactttgtc ccggccagtc cccttgtccg ggaaggggct gagcttcccg acactctacc 1380 ctccccctct tgaaaatccc ctggaaaatc tgtttgcaat gggtgtttcc gcggcgtcca 1440 ggtctgggct gccgggggag gccgagcggc tgctgcagcc tccctgctgc caggggcgtc 1500 ggactccgct tcgctcacta cgcccaggcc cctcaggggc ccacgctcag gacttcgggg 1560 ccacacagca ggacccggtg ccccgacgac gagtttgcgc aggacccggg ctgggccagc 1620 cgcggagctg gggaggaagg ggcgggggtc ggtgcagcgg atcttttctg ttgctgcctg 1680 tgcggcggca ggaagcgtct tgaggctccc caagactacc tgaggggccg cccaagcact 1740 tcagaagccc aaggagcccc cggccacccc cgctcctggc ctttttgcca acgactttga 1800 aagtgaaatg cacaagcacc agcaattgac ttcccttccg tggttattta ttttgtcttt 1860 gtggatggtg ggcagatggg gagagaggcc cctacctaac ctcggtggct ggtccctaga 1920 ccacccctgc cagccggtgt ggggaggagc tcaggtccgc gggagagcga atgggcgcca 1980 ggaggtggga cagaatcctg ggaaggtaca gcggacgccc tggaagctcc cctgatgccc 2040 cagagggccc ttcctgggaa acctcccggg ggggtgcccc ataccatccc acccggctgt 2100 cttggcccct cccagggagc cgcaggagaa actagcccta cacctgggat tcccagagcc 2160 ttctgctggg gctcctgccc ccgacttcgg ataaccagct ccgcacaggt ccccgagaag 2220 ggccgctggc ctgcttattt gatactgccc cctcccagac aggggctggt cgagcccctg 2280 gttctgctgc cagactgaag ccttccagac gccacctcgg tttgggcccc cagggccctc 2340 aggggcccca ggagaggaga gctgctatct agctcagcca caggctcgct cctggtgggg 2400 gccaggctga aggagtggac cctggagagg tcgggaacct tttaacagcc gtgggctgga 2460 gggtggctac taagtgttcg gtctgggaag aggcatgacc cgcaccatcc cggggaaata 2520 aacgacttct taagggaatc ttctcgctga gcgggtgctc tgggccagga gattgccacc 2580 gccagcccac ggaacccaga tttgggctct gccttgagcg ggccgcctgt ggcttcccgg 2640 gtcgctcccc cgactcagaa agctctcaag ttggtatcgt tttcccggcc ctcggaggtg 2700 gattgcagat caccgagagg ggatttacca gtaaccacta cagaatctac ccgggcttta 2760 acaagcgctc atttctctcc cttgtcctta gaaaaacttc gcgctggcgt tgatcatatc 2820 gtacttgtag cggcagctta ggggcagcgg aactggtggg gttgtgcgtg cagggggagg 2880 ctgtgaggga gccctgcact ccgcccctcc acccttctgg aggagtggct ttgtttctaa 2940 gggtgccccc ccaacccccg ggtccccact tcaatgtttc tgctctttgt cccaccgccc 3000 gtgaaagctc ggctttcatt tggtcggcga agcctccgac gcccccgagt cccaccctag 3060 cgggccgcgc ggcactgcag ccgggggttc ctgcggactg gcccgacagg gtgcgcggac 3120 ggggacgcgg gccccgagca ccgcgacgcc agggtccttt ggcagggccc aagcacccct 3180 <210> 73 <211> 1038 <212> DNA <213> Homo sapiens <400> 73 tggcggccgg cgggcacagc cggctcattg ttctgcacta caaccactcg ggccggctgg 60 ccgggcgcgg ggggccggag gatggcggcc tgggggccct gcgggggctg tcggtggccg 120 ccagctgcct ggtggtgctg gagaacttgc tggtgctggc ggccatcacc agccacatgc 180 ggtcgcgacg ctgggtctac tattgcctgg tgaacatcac gctgagtgac ctgctcacgg 240 gcgcggccta cctggccaac gtgctgctgt cgggggcccg caccttccgt ctggcgcccg 300 cccagtggtt cctacgggag ggcctgctct tcaccgccct ggccgcctcc accttcagcc 360 tgctcttcac tgcaggggag cgctttgcca ccatggtgcg gccggtggcc gagagcgggg 420 ccaccaagac cagccgcgtc tacggcttca tcggcctctg ctggctgctg gccgcgctgc 480 tggggatgct gcctttgctg ggctggaact gcctgtgcgc ctttgaccgc tgctccagcc 540 ttctgcccct ctactccaag cgctacatcc tcttctgcct ggtgatcttc gccggcgtcc 600 tggccaccat catgggcctc tatggggcca tcttccgcct ggtgcaggcc agcgggcaga 660 aggccccacg cccagcggcc cgccgcaagg cccgccgcct gctgaagacg gtgctgatga 720 tcctgctggc cttcctggtg tgctggggcc cactcttcgg gctgctgctg gccgacgtct 780 ttggctccaa cctctgggcc caggagtacc tgcggggcat ggactggatc ctggccctgg 840 ccgtcctcaa ctcggcggtc aaccccatca tctactcctt ccgcagcagg gaggtgtgca 900 gagccgtgct cagcttcctc tgctgcgggt gtctccggct gggcatgcga gggcccgggg 960 actgcctggc ccgggccgtc gaggctcact ccggagcttc caccaccgac agctctctga 1020 ggccaaggga cagctttc 1038 <210> 74 <211> 1200 <212> DNA <213> Homo sapiens <400> 74 gtcctaacat cccaggtggc ggcgcgctgg ctccctggag cggggcggga cgcggccgcg 60 cggactcacg tgcacaaccg cgcgggacgg ggccacgcgg actcacgtgc acaaccgcgg 120 gaccccagcg ccagcgggac cccagcgcca gcgggacccc agcgccagcg ggaccccagc 180 gccagcggga ccccagcgcc agcgggaccc cagcgccagc gggaccccag cgccagcggg 240 tctgtggccc agtggagcga gtggagcgct ggcgacctga gcggagactg cgccctggac 300 gccccagcct agacgtcaag ttacagcccg cgcagcagca gcaaagggga aggggcagga 360 gccgggcaca gttggatccg gaggtcgtga cccaggggaa agcgtgggcg gtcgacccag 420 ggcagctgcg gcggcgaggc aggtgggctc cttgctccct ggagccgccc ctccccacac 480 ctgccctcgg cgcccccagc agttttcacc ttggccctcc gcggtcactg cgggattcgg 540 cgttgccgcc agcccagtgg ggagtgaatt agcgccctcc ttcgtcctcg gcccttccga 600 cggcacgagg aactcctgtc ctgccccaca gaccttcggc ctccgccgag tgcggtactg 660 gagcctgccc cgccagggcc ctggaatcag agaaagtcgc tctttggcca cctgaagcgt 720 cggatcccta cagtgcctcc cagcctgggc gggagcggcg gctgcgtcgc tgaaggttgg 780 ggtccttggt gcgaaaggga ggcagctgca gcctcagccc caccccagaa gcggccttcg 840 catcgctgcg gtgggcgttc tcgggcttcg acttcgccag cgccgcgggg cagaggcacc 900 tggagctcgc agggcccaga cctgggttgg aaaagcttcg ctgactgcag gcaagcgtcc 960 gggaggggcg gccaggcgaa gccccggcgc tttaccacac acttccgggt cccatgccag 1020 ttgcatccgc ggtattgggc aggaaatggc agggctgagg ccgaccctag gagtataagg 1080 gagccctcca tttcctgccc acatttgtca cctccagttt tgcaacctat cccagacaca 1140 cagaaagcaa gcaggactgg tggggagacg gagcttaaca ggaatatttt ccagcagtga 1200 <210> 75 <211> 900 <212> DNA <213> Homo sapiens <400> 75 caccttcccc gaggtaatta ttttctgggg ggtaggggtg ggggttggga gggtgaagaa 60 aggaagaaaa agaaggccga tcacactggg caccggcgga ggaagcgtgg agtccattga 120 tctaggtact tgtggggagg ggagaacccg agcagcagct gcaaacggaa gggctgtgag 180 cgagcgggcg ggcgggtggc tggcagcgag gccaccagca gggggggccc gggccgaggc 240 cgcgccacct cggcaccacg cgggcagccg gtgcggcggg gtcgccacgg ccaggggagc 300 gctgggtgcc caccatggca gttatgcaag cggtgacccc ctggtcttgc ctccccgccg 360 ccctgcactc cttcctcccc gctgccgaca cttggatctc tctagctctt tctctcccct 420 gtgttttcaa acaggaagtg cacggctgtc tataacgtgc tgccgggtct caggatggag 480 gagtgaagtc tcctgtcgcc gtggttccag cctccggagc tcgcccaagc cgcgtcccca 540 gagagcgccc tgagagaaca gggtggccgc ttggtccagg tgcgcggggt cgggtctggg 600 tccagggagc gggtcgggaa gtctgcggca cggagcactg ctagtgtcgg atctgcatct 660 ccagctctgt gctgcagctt cacttgcccg ccccccacca ctggcttctc acccggggtc 720 tctgccaaac tctggctgct gccgccctgg gttcgggccg gcggaaggcc ctgggcgtgc 780 gctgcggagc cgcctgcgag gactccacta gggcgctttc caggctggac tgccccgggc 840 tgcgctggag ctgccagtgc tcggggagtc ttcctggagt ccccagctgc cctctccacc 900 <210> 76 <211> 200 <212> DNA <213> Homo sapiens <400> 76 ctcttcccaa gttacgccac cggtcgagga cggcaggaga cccccgagtg cagagaaagc 60 tcaaaccggc agcgaagtcg gtcctagcca agctgaaaaa acgtctcgga tttcgcggac 120 agcggcctag acacagcccg atcttccagt cctagtgccc tggtcgagac ggttctatcc 180 ttttgcaaag aagccggaaa 200 <210> 77 <211> 400 <212> DNA <213> Homo sapiens <400> 77 tctcggttgc aatccccacc ctcctcaccc agcagggcag gaggcaccca acttggagga 60 gaaaggggtg ggggaggtga aacagagacc ggagagtcac gagggctggg ccgccgagag 120 caggagaata taccgtgtca cacacctcca ttctctcaca cacgttgcag acacaaatca 180 ctgacggttt ccacgtgctg cgctcgtgag cggaggtgtt caaagagggg gcagatgagt 240 tacttcccga gacggaaccg ggggtcccac gtccgccgcc ttcagtagca caaccaatct 300 ctgaacactc aaaccgcgca tctctggcgc atcaccatcc tatttaaggc cacgggctcc 360 gcccttttcc tcccctccct tcttttccac tctttttcca 400 <210> 78 <211> 700 <212> DNA <213> Homo sapiens <400> 78 ctgccagaga tgtgtctgtc ttgcgccccg catgcactgc ctgcggggct gcgctgcact 60 ccccggcggc gccacgggtc tggcccccgc gcttctacgt gttgggggga tgcatggacc 120 ttggagatcc gtagttggcc ctaaccttct cggaatctcc tctgcacgcg ctgcctgttc 180 ctcctctgca cgctctgtcc gttcctttgc aacttctgtg ggaattgtcc tggcgtggga 240 aacgcccccg cgctctttgg cacttagggt gtgagtgttg cgccccttgc cgcagcgctc 300 agggcagcat cccgctcgag gatgcagggt tctcaccaag cagtgagggg gactcacgcg 360 ccgccgggga gcggagccag gctccgagaa gggagcaggc tcgagccgct gggttttcgc 420 aagccttggg gcctctggcc gcccttccat gcctccgggc gcgggcggct cagcaggtcc 480 ccggcttcgg gaagttttgt gcgcggatcg ctggtgggga gggcgcgcgg gccagtggct 540 gagcttgcag cgaagtttcc gtgaaggaaa ctgcatgtgc ctttggaggc gactcgggac 600 tgctgtaggg tggactgggt gtctatggag ttgcgggtca gagcgagtag ggtgggtcct 660 ttcctgggac aggactggga attggggctc gaagtagggg 700 <210> 79 <211> 200 <212> DNA <213> Homo sapiens <400> 79 aggggtgtcc tccaacatct ctgaaccgcc ttcccttcct cctcactggc gccctcttgc 60 ctcagtcgtc ggagatggag aggcggctga agattggcag gcggcggcca gggtcgaggc 120 tgggagactc agagccgctg aggctgccgg agctcaggga gccgcttagg tagctgtcgc 180 ggtccgacag cgagtccggg 200 <210> 80 <211> 5000 <212> DNA <213> Homo sapiens <400> 80 tctgactctc gggctggagc agccgagaca gcgctcccca gcgggactac agaatcccgg 60 gtgtcggcct gggggccctg gattggcagt ggtggagtct tctgagccta acagctacta 120 ggaatgacag agttgcagat ggctttgtcg cccgcggggc ggctcaagcg tcctgggtcc 180 caggcctctg tcctacggcc aggccgccgg ctcaacgggc cgaagggaat cgggctgacc 240 agtcctaagg tcccacgctc ccctgacctc agggcccaga gcctcgcatt accccgagca 300 gtgcgttggt tactctccct ggaaagccgc ccccgccggg gcaagtggga gttgctgcac 360 tgcggtcttt ggaggcctag gtcgcccaga gtaggcggag ccctgtatcc ctcctggagc 420 cggcctgcgg tgaggtcggt acccagtact tagggaggga ggacgcgctt ggtgctcagg 480 gtaggctggg ccgctgctag ctcttgattt agtctcatgt ccgcctttgt gccggcctct 540 ccgatttgtg ggtccttcca agaaagagtc ctctagggca gctagggtcg tctcttgggt 600 ctggcgaggc ggcaggcctt cttcggacct atccccagag gtgtaacgga gactttctcc 660 actgcagggc ggcctggggc gggcatctgc caggcgaggg agctgccctg ccgccgagat 720 tgtggggaaa cggcgtggaa gacaccccat cggagggcac ccaatctgcc tctgcactcg 780 attccatcct gcaacccagg agaaaccatt tccgagttcc agccgcagag gcacccgcgg 840 agttgccaaa agagactccc gcgaggtcgc tcggaacctt gaccctgaca cctggacgcg 900 aggtctttca ggaccagtct cggctcggta gcctggtccc cgaccaccgc gaccaggagt 960 tccttcttcc cttcctgctc accagccggc cgccggcagc ggctccagga aggagcacca 1020 acccgcgctg ggggcggagg ttcaggcggc aggaatggag aggctgatcc tcctctagcc 1080 ccggcgcatt cacttaggtg cgggagccct gaggttcagc ctgactttcc cgactccgcc 1140 gggcgcttgg tgggctcctg ggcttctggg ctcaccctta cacctgtgta ctaaagggct 1200 gctaccctcc cgaggtgtac gtccgccgcc tcggcgctca tcggggtgtt ttttcaccct 1260 ctcgcggtgc acgctttttc tctcacgtca gctcacatct ttcagtacac agccactggg 1320 tctccctgcc cctccagcct ttcctaggca gctttgaggg cccagacgac tgaagtctta 1380 ctgctaggat gggaacacga tgaaaaagga aggggcccag tcaaaagtcc tctcctcttc 1440 ggtttttctt caactgtcct tcacaaaaac atttatttct gtcccagcgc cctggcggat 1500 ttcggcagat gggccctagg gggttgtgga ggccaaattc ccaggatgct ggtcctgcct 1560 ttttcattgg ccaaaactgt atttcctaca acgactaaag ataaccaaga actgagtaga 1620 ccctgttctc tcaccagatc tccctggctc tgtttaactt ttcctggtgc aatgcgatgg 1680 caccaccagc tccccaggca ggcaccactc cctcaagata ccatttgggg tagggatttg 1740 agtcctggag agggtcagcg gggcgccggg gtgggggtgg gaaggagact gacagggaca 1800 caccgcgagc tccgcatact ctcctctgcc ccctgtagcc cggggcttta atgaccccaa 1860 gcagatttcc tgtctctggt ctagccagct gcccctaggg ctggatttta tttcttcatg 1920 gggtttcacc ctaaagggcc ccctggtcat gggacctggt tgggaacaaa tgaaagatgt 1980 cttgtagcaa atgctttcag gggagcagaa aagaagattg ggcacttcca gtcacttggt 2040 cactttaggt ggctggaaca aaactggtga ctttcacgac tgctacaggg tgagggggtg 2100 aagggtggca gagaggtgac aagccactgg gaatcctatt cagtggggat gccgacaggg 2160 agtggctgta atcaactgag caacatctgt gtgaatgtta ttcacaggtc aggacagcag 2220 cttggtcttc ccaggtgagg aactgaggac tggcctgcat agatttgtgc agtaggtgag 2280 tagcttccaa atttattttc agaacttcca tgtagtacct gcctctccat ttaaatattt 2340 tttaaaattt tatttattta aatattttct tggttagctt tccaagaggg aggaaaagag 2400 gggagttgca acaagtagtg cccctatgct gggattcatt ttccagagta aagcctggga 2460 ctggcaccct gacccctacc ggcaggtgaa aactccaggc aaactgctga gatcccacct 2520 gggctggctg agatagtgcc tggggtgcat ccctcagcag ctgccacctg ggccctgggg 2580 ccatctcttt ctctggcatc aagcagccag gtgtcaaggc cttcccagca atccatgctg 2640 catggctggg tcttgttcta gcaggtcgat gggcagggac tggtagctta gccagggcac 2700 cagtgcgtgg ctgtgggttt gtgtgcttct gtggagaagc atgatgtgta tgtgtgtgtg 2760 tgggcacagg catgaggaag ggttcatttg tgcaggtatc tcccatgtat atcagtgtgg 2820 gagagtgcct gaggatgtgt ttgtgtgtct gaaaatgggc ggagggtctg ttgtgctaat 2880 gtgtgcaggg gtgaacatgt gtgtgacagt ctgtgtgttt ccctgagtgg tggctgcgtg 2940 agagggtgag gggatttggt gttgtctacc atgcccggca catagcaggc tcttaataat 3000 cttgaattta attaatgtta aatgtgtatg ttcccatcct tgtggaagtt ggtatagagc 3060 ctgttttcct gtgattgtga gactggaaaa tgggggacgg gcaggggcga gacaggatac 3120 agaggctact gttttcttcc tccctagaag taagtacata gaagagtggg ctctggcacc 3180 tcacgggaca tcaccaagtc ctgtgtggct ggctaggctg tcccaaggtg gcttcaggca 3240 tcacttgaat cttttgagac cttcaggcag tagcctgcca ttcaccctgt cagtcagcag 3300 aagttgggcc cacacaggcc atagaaacac agagcagttc ccgggaggac ctgagctgtc 3360 cctgagagca gagcttccag gagaggccgc aggaactgcc ttgaccggaa ttcctcttgg 3420 ggtgcaaagg tggagggaca catggtgcga ccccaggcag aggactgcag ccactccgtg 3480 cagtcccagc ctctggggta gccccttgac ctccaggcct gcacagatcc aaggccgagg 3540 tccaggctcc agcgccaaat tagctggcct agcagcctgc agccgctcta atctcaacta 3600 ggaaggaatc cttgcgctta gaaagtccaa gcgaaagggt attctgattt tatcccggtt 3660 ttaccagaaa atgctgaaag gaaaagcccc gagaggacac agtgctctag gaactcgggg 3720 cgccacgagc gcctcatccc ctcccttccg cccggccgcg gtgccctggt cgctgaggga 3780 cgcggtcagt acctaccgcc actgcgaccc gagaagggaa agcctcaact tcttcctctc 3840 ggagtcctgc ccactacgga tctgcctgga ctggttcaga tgcgtcgttt aaaggggggg 3900 gctggcactc cagagaggag ggggcgctgc aggttaattg atagccacgg aagcacctag 3960 gcgccccatg cgcggagccg gagccgccag ctcagtctga cccctgtctt ttctctcctc 4020 ttccctctcc cacccctcac tccgggaaag cgagggccga ggtaggggca gatagatcac 4080 cagacaggcg gagaaggaca ggagtacaga tggagggacc aggacacaga atgcaaaaga 4140 ctggcaggtg agaagaaggg agaaacagag ggagagagaa agggagaaac agagcagagg 4200 cggccgccgg cccggccgcc ctgagtccga tttccctcct tccctgaccc ttcagtttca 4260 ctgcaaatcc acagaagcag gtttgcgagc tcgaatacct ttgctccact gccacacgca 4320 gcaccgggac tgggcgtctg gagcttaagt ctgggggtct gagcctggga ccggcaaatc 4380 cgcgcagcgc atcgcgccca gtctcggaga ctgcaaccac cgccaaggag tacgcgcggc 4440 aggaaacttc tgcggcccaa tttcttcccc agctttggca tctccgaagg cacgtacccg 4500 ccctcggcac aagctctctc gtcttccact tcgacctcga ggtggagaaa gaggctggca 4560 agggctgtgc gcgtcgctgg tgtggggagg gcagcaggct gcccctcccc gcttctgcag 4620 cgagttttcc cagccaggaa aagggaggga gctgtttcag gaatttcagt gccttcacct 4680 agcgactgac acaagtcgtg tgtataggaa ggcgtctggc tgtttcggga ctcaccagag 4740 agcatcgcca accagaacgg cccacccggg gtgtcgagtc ttggtaggga aatcagacac 4800 agctgcactc ccggcccgcg ggccttgtgg catataacca tttatatatt tatgatttct 4860 aattttatta taaaataaaa gcagaaatat ttcccgaaga acattcacat gagggcatta 4920 cggggagacg gcaagtcggc ggctcggggg gcgcgctcag ccgggagcgc tgtagtcaca 4980 gtcccgggag gaagagcgcg 5000 <210> 81 <211> 1500 <212> DNA <213> Homo sapiens <400> 81 tggaacaagt gtcagagagt aagcaaacga ctttctgagc tgtgactctg ctcctcgact 60 gcccacgtgc tctccgctgt ctgcactcct gcctcacctg ggctgactcg gactctccac 120 ctcctttgct gcttccggca tgagctaccc aggagcctaa ggcgctcctt cccgcaactc 180 cggtccccgc gccccgggac tgcaaatcct ttaaacagag gccccagagc taggggtttt 240 cccaggctct ggtgggcgtg ggctgacagt cgctgggagc cccgcaacag gggggatgtc 300 caggcaggta tgcacccagc tcccggcgtt tcccggagtc accacaatgt ttccctttct 360 ctctccccca cgtatgctgc taggggtact ccccagatag gattttcttt gtcttttctc 420 ctagtaacac cgaagccctc tcgtgcccgg ggactgcaga ggaacgccag accatccgga 480 ccttgcggga tggctcggtg tgtgtgtttt actgtgtgtc ggagtgtcgc gcatgtgtgc 540 gtgttggggc gcgttatcaa caggggccta gggcaccccc actctttctt gctctcttcc 600 cccatcactt catggacctc cgaggcgcaa agcgctcgac cctctcctgg gctcagtggc 660 ttgggtactc cgggctgagc tcagctgggg agtcccctta cccagcccgc accggcaccc 720 cgaagcttca aagttgcggc aaacagttgc ggggagcaga ggaactgagg tccaggccag 780 cgcgcccgcg gtcgctcgcc ttggggagca ggctgagccg agggtcgtgc gggtgcgcgg 840 cagaggcggt aggaggcgga ggagaggggg gagaaagagg gggcggtggg gaacagctgc 900 cggggtaggc gaggcgcaag gtggctcccc gcggccccgc gccccgcggc tctcggacgc 960 accaggcagc caatggctgc gcagaggtgt acagcagatg gcgtctgact gcgccgttcc 1020 ttcctcctcc tcctcctcct ccttctcttc ctcctcctcc ttctcttcct cctcctcctc 1080 cttcagtgct gaggagccag agtcgccgcc gggttgccag acgctggaat gggtggtctt 1140 ccgacacaca ccaccatctt tcttgcgctc gggaagctcg gggctcagcg gctcccagag 1200 gttacggcgg cggctctggc gagacgggtg agtgcaagca cgcggagccc cgagtcgggg 1260 atgccgggcc ccctggccgg ccgactgggg cgcggggtgg cagcgccggg gaagggggcg 1320 cgctgccggc gcagactttg ctctttcctc gccggacagc catcgtcgcc ccttctccca 1380 gccagacgcg ggaacttgga agcggatctt ctcggacgcc tctggcttgg ggctgcggga 1440 agcgtgggct gcccggggcg cagtgtgcgg agaccctcta ggcgggcggg gacgccccac 1500 <210> 82 <211> 800 <212> DNA <213> Homo sapiens <400> 82 gttattatcc acggggtcct aattaaagct tgattaaaat gcccttcttt ctctaaaaaa 60 ttacgaacta ggcaacttca tacattttga atggcgcagt gtttcctctt ccaactgttt 120 agtttgtagt atactatgta agcaacatca attatcaacc cttgcaagat gacaacatga 180 gcctgtgggg gaagcacttg aggggaggga ggagaaactt ctctttttta ataatcagcc 240 ggaaacaatg tttaacaaga atctgatgag gtcactgcag taaatatttt tcctcttaca 300 gagccaatca tcacggaggg atcccctgaa tttaaagtcc tggaggatgc atggactgtg 360 gtctccctag acaatcaaag gtgtttgctt tctgctctgt tgcttttaaa ttgtatggga 420 aaggaagatt ggtccgacgg cgcgcttgtg gcccggccgg agcttgcgtg cgcgttctga 480 cggctgggtg ctgtgttaca ggtcggcgca gttcgagcac acggttctga tcacgtcgag 540 gggcgcgcag atcctgacca aactacccca tgaggcctga ggagccgccc gaaggtcgcg 600 gtgacctggt gcctttttaa ataaattgct gaaatttggc tggagaactt ttagaagaaa 660 cagggaaatg accggtggtg cggtaacctg cgtggctcct gatagcgttt ggaagaacgc 720 gggggagact gaagagcaac tgggaactcg gatctgaagc cctgctgggg tcgcgcggct 780 ttggaaaaac aaatcctggc 800 <210> 83 <211> 40 <212> DNA <213> Homo sapiens <400> 83 tccctgctgt gggacccgag gagaggagaa ctggttcgct 40 <210> 84 <211> 500 <212> DNA <213> Homo sapiens <400> 84 tctctctctc tctcttgctt ggtttctgta atgaggaagt tctccgcagc tcagtttcct 60 ttccctcact gagcgcctga aacaggaagt cagtcagtta agctggtggc agcagccgag 120 gccaccaaga ggcaacgggc ggcaggttgc agtggagggg cctccgctcc cctcggtggt 180 gtgtgggtcc tgggggtgcc tgccggcccg gccgaggagg cccacgccca ccatggtccc 240 ctgctggaac catggcaaca tcacccgctc caaggcggag gagctgcttt ccaggacagg 300 caaggacggg agcttcctcg tgcgtgccag cgagtccatc tcccgggcat acgcgctctg 360 cgtgctgtga gtacaacctg ctccctcccc gggcacagat atgacagagg ggcttagagg 420 gggcccagct ttgagatggg ttgttcttat gtcacaggac agagtgatct gacatgcaca 480 cttccccgcc accctgtcat 500 <210> 85 <211> 500 <212> DNA <213> Homo sapiens <400> 85 tgtcctcgaa gaagggcctg agcagcagca gaggacccca ggcgaccgtg cctgagccgg 60 gcgccgacga cgactgagca cctgatatgt ccccggcact cgcagccccg cggccggagt 120 cgctgtgggt gagcggtcgt cgagcttcac agaggccggg ctctgtgcca gggccccgac 180 agggcaggaa gcagatagag tcccacaagc acaagcccag tgcgcagaaa gggttactta 240 aaaaataagt tctgtgataa aatcaaacag ggtgaagggc tggaaacagg tcatgagggc 300 gcaaacaggt cgtgagggcg caaacaggtc gtgagggcgc aaacaggtcg tgagggcgca 360 aacaggtcgt gagggcgcaa acaggtcgtg agggcgcaaa cagatcgtga gggcgcaaac 420 aggtcgtgag ggcgcaaaca ggtcgtgagg gtgcaaacag gtcgtgaggg cgcaaacagg 480 tcgtgagggt gcaaacaggt 500 <210> 86 <211> 300 <212> DNA <213> Homo sapiens <400> 86 aaatgagacc tctggggaga ctgtcaaccc caggggtaaa acaaaaattc tgatcagaaa 60 ctgagtttcc caaagaaggg gctaaatgtt ttccaacact ttcggggctc agggaagatg 120 actctgtaag gacactgaga atcttcctcg cgtgccacgg ggaggaggac tgggggcgtt 180 tgaggggctc agcgcaccag aggagtgagg tggaggaggg cgttcccgcg tcctcctctt 240 caatccagag cagctcaacg acgtggctcc ctttctatgt atccctcaaa gccttcgcgt 300 <210> 87 <211> 600 <212> DNA <213> Homo sapiens <400> 87 taggctctag tggacctagc agtgggagag ctacttgggc tggtttcttt cctgacgctg 60 cagggatggg catcggcctg gaaccagaag cgcaggagct gggccacggc agagtaatta 120 agaaaataat gaaattgatg gcggatgggg gcgctagaaa tcctggggcg tctacttaaa 180 accagagatt cgcggtcggc cccacggaat cccggctctg tgtgcgccca ggttccgggg 240 cttgggcgtt gccggttctc acactaggaa ggagcctgaa gtcagaaaag atggggcctc 300 gttactcact ttctagccca gcccctggcc ctgggtcccg cagagccgtc atcgcaggct 360 cctgcccagc ctctggggtc gggtgagcaa ggtgttctct tcggaagcgg gaagggctgc 420 gggtcgggga cgtcccttgg ctgccacccc tgattctgca tccttttcgc tcgaatccct 480 gcgctaggca tcctccccga tcccccaaaa gcccaagcac tgggtctggg ttgaggaagg 540 gaacgggtgc ccaggccgga cagaggctga aaggaggcct caaggttcct ctttgctaca 600 <210> 88 <211> 800 <212> DNA <213> Homo sapiens <400> 88 gaggttgctg actcaggagc caggagctga gaaactccta ggctagcagc cgttgagcct 60 aattttattt tctggctttc tccgaaatgt ctcgtttccc tcatctttct ggtccttttc 120 gtctctctta ttttccccaa aacgtctacc tcacttcgtc ttcctttctc ctcccctccc 180 cctctctttc ctctatactc tcttcccatt tagccttgca ggcccctcct ccccggtgtt 240 ggagagctca aagacgcgcg aaactcaagg atctggccct gaccagggac gggattaggc 300 gggaagtggt gacggcctga aaaggctggg ctcgaacccg tgccttcctg aaaggactct 360 ccccgccaca agtcacaccc acccgcaggc ctgctggcca aagaaacaaa ggagtcgggc 420 gtggatccag gagaaacagg ttttcgctct cggatctccc tgggcaaatc agggatcctg 480 agcgctatac cccgcagtcg tacggagcct ctgggaaagg ggatttaagg gtgacttcca 540 ctttcagctt cggctacttg ttgcctgcgg tccaagcctt ctctgcttcc tcctacctcg 600 tcttaggcct ctgtagaaag tgcacgccgc gtttcccctt ccaggctctg agagggcctg 660 caggcccgtg gccgcctccg acaagatgcc ttccagtgct aggggggcca ctttggcggg 720 atgggggtcg gttggttaaa aaaaacttaa gttctggctc agtcgagtgt ggcaaaagcc 780 gagggtcggg ggttgggggg 800 <210> 89 <211> 2000 <212> DNA <213> Homo sapiens <400> 89 tactgacctg gtctccgcct caccggcctc ttgcggccgc tgcagaagcg cactttgctg 60 aacaccccga ggacgtgcct ctcgcacagg gagcgcccgt ctttgctggg gctggagcgg 120 cgcttggagg ccgacactcg gtcgctgttg gactccctcg cctgccgctt ctgccggatc 180 aaggagctgg ctatcgccgc agccatagct gctcagcgag ggcctcaggc cccagcctct 240 actgcgccct ccggcttgcg ctccgccggg gcgagggcag gacctgggcg gccagggaaa 300 gggcagtcgc ggggaggcag tgctaaaatt tgaggaggct gcagtatcga aaacccggcg 360 ctcacaaggt tagtcaaagt ctgggcagtg gcgacaaaat gtgtgaaaat ccagatgtaa 420 acttccccaa cctctggcgg ccggggggcg gggcggggcg gtcccaggcc ctcttgcgaa 480 gtagacgttt gcaccccaaa cttgcacccc aaggcgatcg gcgtccaagg ggcagtgggg 540 agtttagtca cactgcgttc ggggtaccaa gtggaagggg aagaacgatg cccaaaataa 600 caagacgtgc ctctgttgga gaggcgcaag cgttgtaagg tgtccaaagt atacctacac 660 atacatacat agaaaacccg tttacaaagc agagtctgga cccaggcggg tagcgcgccc 720 ccggtagaaa atactaaaaa gtgaataaaa cgttccttta gaaaacaagc caccaaccgc 780 acgagagaag gagaggaagg cagcaattta actccctgcg gcccgcggtt ctgaagatta 840 ggaggtccgt cccagcaggg tgaggtctac agaatgcatc gcgccggctg cggctttcca 900 ggggccggcc acccgagttc tggaattccg agaggcgcga agtgggagcg gttacccgga 960 gtctgggtag gggcgcgggg cgggggcagc tgtttccagc tgcggtgaga gcaactcccg 1020 gccagcagca ctgcaaagag agcgggaggc gagggagggg ggagggcgcg agggagggag 1080 ggagatcctc gagggccaag cacccctcgg ggagaaacca gcgagaggcg atctgcgggg 1140 tcccaagagt gggcgctctt tctctttccg cttgctttcc ggcacgagac gggcacagtt 1200 ggtgattatt tagggaatcc taaatctgga atgactcagt agtttaaata agccccctca 1260 aaaggcagcg atgccgaagg tgtcctctcc agctcggcgc ccacacgcct ttaactggag 1320 ctccccgcca tggtccaccc ggggccgccg caccgagctg gtctccgcac aggctcagag 1380 ggagcgaggg aagggaggga aggaaggggc gccctggcgg gctcgggatc aggtcatcgc 1440 cgcgctgctg cccgtgcccc ctaggctcgc gcgccccggc agtcagcagc tcacaggcag 1500 cagatcagat ggggattacc cgccggacgc aaggccgatc actcagtccc gcgccgccca 1560 tcccggccga ggaaggaagt gacccgcgcg ctgcgaatac ccgcgcgtcc gctcgggtgg 1620 ggcgggggct ggctgcaggc gatgttggct cgcggcggct gaggctcctg gccggagctg 1680 cccaccatgg tctggcgcca ggggcgcagg cggggcccct aggcctcctg gggctacctc 1740 gcgaggcagc cgagggcgca acccgggcgc ttggggccgg aggcggaatc aggggccggg 1800 gccaggaggc aggtgcaggc ggctgccaac tcgcccaact tgctgcgcgg gtggccgctc 1860 agagccgcgg gcttgcgggg cgccccccgc cgccgcgccg ccgcctcccc aggcccggga 1920 gggggcgctc agggtggagt cccattcatg ggctgaggct ctgggcgcgc ggagccgccg 1980 ccgcccctcc ggctggctca 2000 <210> 90 <211> 800 <212> DNA <213> Homo sapiens <400> 90 gggggacaca gagaggaggg gttgcgggcc tgtgagaatg aagagcacag agcggagagg 60 gggaggagga gggaaaggaa ggcgtggcag tgagagagaa gaggaagaag agaggaggag 120 tggggagggg agggagagca agacagcagc gggtctggat tcccctccga gccacatctg 180 gtcaggttct aagtaattag aagattttcc cattggttta cccaagggct ctctctctga 240 ttaattttcg aaagagttgg ccaattttaa tcatagcaaa cacgatgatc acggtgatca 300 tggcctgaac agctaaaagc agaaaataaa acccccagaa cggactatga tcttgacctt 360 tgcccgtggt caccggctgg gcccacaccc agggttctga gctgttggga gccaaggctg 420 ggtggacagg ggcttccgag gagctgtccg cagcggggcg gggaggcggg ccccgggggc 480 ccgggcactc cgcgtcaccc cccggcaggg cccagagcgg caggccggcg tgcgccccag 540 ggcctgcgca ccgtgggggc tcttccccgc ccacgaggcc taggtgctgc cgcagccacc 600 ccaggaaggg ccccaggcca cagtcgcagc gccaggagtt gtgccccaac aggacctccg 660 tcagccgggg cagagcccca aacacgtcgc caggcagggt ctccagctgg ttgtggtcga 720 gctggacgct ctccaggctg ctgagattgc ggaagagggc acggggcagg gcgcgcagcc 780 tgttgcggcg cagggacacc 800 <210> 91 <211> 550 <212> DNA <213> Homo sapiens <400> 91 gccccggtgc accgcgcgtc cagccggccc aactcgagct agaagcccca accactgccc 60 agtgcctgag ttgcagtctt gggtccttta gaaacctgga gatgtgcgta aaattcagat 120 gccggtattc ccgaacttcc ccaggcctca gcatatctcg gcggcctgtg gacagatggg 180 aggctaccaa tcgctccggc gtccgcagcc cgacccctgc cgccagaccc cggacgtctt 240 ccggataata aagttcccgc tctaattcat tttccctaat ctggacgccc ctaatctaca 300 gcttttattg cgcccagtta aaagtcgagg gaattcgctg tccctccgcg ctcggataat 360 tacccctaaa tggccacggc agccccttgt gtttcctgga gattagaacc ccgcagtcat 420 caatggcagg gccgagtgag ccgccaatca cctccgctca ctccctgaga gccgctggcc 480 tgggccgcag gaggagaggc cataaagcga caggcgcaga aaatggccaa gccccgaccc 540 cgcttcaggc 550 <210> 92 <211> 2000 <212> DNA <213> Homo sapiens <400> 92 agggtgcctc tgttcaaatt agaaaaaggc gccccctcag ggcagactca gcccagctgc 60 caggggacaa gtcctggcta acgggagctg gagctgggtt tcacctccag gtgcctcctt 120 ggcggggcgc cccgtgcagg ctacagccta cagctgtcag cgccggtccg gagccggagc 180 gcgggaatca ctcgctgcct cagcccaagc gggttcactg ggtgcctgcg gcagctgcgc 240 aggtggagag cgcccagcct gggaggcagt agtacgggta atagtaggag ggctgcagtg 300 gcagaagcga gggtggccgc agcacttcgc cgggcaggta ttgtctctgg tcgtcgcgca 360 ccagcacctt tacggccacc ttcttggcgg cgggcgccga ggccagcagg tcggctgcca 420 tctgccggcg ctttgtcttg tagcgacggt tctggaacca gattttcacc tgcgtctcgg 480 tgagcttcag cgacgcggcc aggtctgcgc gctcgggccc ggacaggtag cgctggtggt 540 taaagcggcg ctccagctcg aagacctgcg cgtgggagaa agcggcccgc gagcgcttct 600 tgcgtggctt gggcgccgcc ggctcctcct cctcctccgc gacgcctgcc ggcccgctgc 660 cgcccccgcc gccggccccg ctgcacagcg cggacacgtg tgcacctctg gggccaacac 720 cgtcgtcctc ggtccttggg ctgcggtcgc ctgcggaccc cggtgggaac agaaacaaga 780 gactgtcagc gccacagacg aggtgaggcc gggcctcaac tgcaggggtc acgggagtgg 840 ggcggaaata cactttgatc ccactcaagc ggagcggagg tctgggaggc cctgggcccg 900 ggagaccagt cttagactct tgccccactg ggtatcccat ctaggcctct tctggggagg 960 gcggcagact cagccgctgt gtcaacgctg tgttgtcgag accagctccc caccctctct 1020 gggccccagg ctcccctcag taacttgggg cactcgaccc gagcatccgc gaaagccctc 1080 ccggctctca gcgttgagca ttgggattct agactgcatt tccgtctctc tgcttgggtt 1140 cacgcgcctc tccacactta gttcacacgc acacacgcgc gcgtcctcgc agcacacact 1200 tgtctggtgc aggtaaggga aggtggaggc ggatcctggg gccaaaggta tttagaatct 1260 ttcaccctca gccgcctggg attgctgtga gagacatgga aacaggctga gccgaggcct 1320 tagatgagag gatggactgg agagtaaaga gggagggttg cccctgcatc gagtttttgg 1380 accctgatcc cacaccagct tctcggtctc gtacccgccc ttccgaagaa ctccagcaga 1440 aaggtccagc ggtcccctgt gcttgaggcc tacagaagct tgtacccaac tagggcaggc 1500 acccgggtct tccagaccac aggacaggac aggccacggc tgaggaggcc tctctcctgc 1560 ctccaggatg aactaaagac ccaatccggg atcttcggcc tagggctgct ctcccagacc 1620 tggggtctga gaaagccaaa ccagcccttt ccccaaagct ctagttctgc agattctcag 1680 ctctggccca ctcggaggtg ttcttcacca cctatccacc tactgtgggg cccggccctg 1740 ggaccttgaa ctggcaggtc tctggtccag agctaggtca ctggctacct gaggtctctg 1800 aacccctcac ttttccgctt ccctgatttt ggggatttgg ggacagacac ggcagaaagc 1860 actggcgacg aactcaaaaa ctcccgaacg caaggggcag cggttctccc aacccagtct 1920 aatgcacatt ggcccaggat gtctcaggcc tcaccccagg acgtagggct ctgaggagct 1980 actccggtct ctcgcgggct 2000 <210> 93 <211> 1000 <212> DNA <213> Homo sapiens <400> 93 gagaagggat gtggcggggg gctcctccgg ccctggactc cctgggtgga ctagaaaagg 60 gcaaagaagt ggtcacatct gtgggccaga ctggtgcgcg atctttggag gcgcagcagc 120 aaggccgcgc cagggctgag cccagaccgc ccacgaggag gcccgccagg cccggagcag 180 cggcgcgtgc gggggcgtgc cgagcgcagg ctctagggcc cctgcttcgc cccagctgga 240 ccccgcgggc ggtcggtgca gctcgagcgt gtgggctgcg atgccctgcc tgagacttcg 300 ggctagggat gcgggcggga agtgggggtg cggcggcagc tgcagattag attccttttt 360 tttttggccg gagggacgtg caaacttcta gtgcccgggc caagagggcg accccggagg 420 tgcgtaggtg gccctccggg ttcccgcttc tcctagtgcc tctgaaaata ccgtcagggt 480 aaagggagac aggcagtaag tcttaccacc accgcccttt ccccatgtca ttggccaaaa 540 actgaacatt aagataaagc agctgtttca gtcaatggaa agcggtaggg cgaggttgta 600 cccaaaaccc ggtttagacg gccaatgaag tcctaggaaa agccgccccg ggggcacgtt 660 caggtggagc ggctgcacct cgggtcgttc taagggatgg gctgcgtggt acccacggaa 720 ttcatgggtc caaaaggtcc tggtcacctg tccaaacatc catcccctgg cgcatggcgg 780 ttgacaagat ggcccggcca cccagaggaa ggaggatccg ggacggggaa cttcgcgccg 840 ggaagctgta gcccagagct gcagctcagc attcgcaaga gattcatctt ttttttctct 900 cgtgttcgga gaaacagata aacaagacac cgcctcatca gataagaacg tctccttcga 960 tgtcacggat ttcaagaggt agctggagaa actgacgtca 1000 <210> 94 <211> 1300 <212> DNA <213> Homo sapiens <400> 94 caggtcaggc agaacttctg cccttcccgc tactggcacc ccaagcaggg atgcactggg 60 atgcgtggca ggggcgggat ctcctgggag cgtctcagcc cagcagggag tggggaagca 120 agagggaagg cttaccttcc tcggtggctg gcaggaggtg gtcgctgcta gcgaggggga 180 tgcaaaggtc gttgtcctgg gggaaacggt cgcactcaag catgtcgggc caggggaagc 240 cgaaggcgga catgaccggg gcgcagcggt ccttcacctg cacgcagagc gagtggcatg 300 gctggatggt ctcgtctagg tcatcgaggc agacgggggc gaagagcgag cacaggaact 360 tcttggtgtc cgggtggcac tgcttcatga ccagcgggat ccaagcgccg gcctgctcca 420 gcacctcctt catggtctcg tggcccagca ggttgggcag ccgcatgttc tggtattcga 480 tgccgtggca cagctgcagg ttggcaggga tgggcttgca attgctgcgc ttgtaggaga 540 agtcgggctg gccaaagagg aagagcccgc gcgccgagcc caggcagcag tgcgaggcga 600 ggaagagcag cagcagcgag ccagggccct gcagcatcgt gggcgcgcga ccccgagggg 660 gcagagggag cggagccggg gaagggcgag gcggccggag ttcgagcttg tcccgggccc 720 gctctcttcg ctgggtgcga ctcggggccc cgaaaagctg gcagccggcg gctggggcgc 780 ggagaagcgg gacaccggga ggacagcgcg ggcgaggcgc tgcaagcccg cgcgcagctc 840 cggggggctc cgacccgggg gagcagaatg agccgttgct ggggcacagc cagagttttc 900 ttggcctttt ttatgcaaat ctggagggtg gggggagcaa gggaggagcc aatgaagggt 960 aatccgagga gggctggtca ctactttctg ggtctggttt tgcgttgaga atgcccctca 1020 cgcgcttgct ggaagggaat tctggctgcg ccccctcccc tagatgccgc cgctcgcccg 1080 ccctaggatt tctttaaaca acaaacagag aagcctggcc gctgcgcccc cacagtgagc 1140 gagcagggcg cgggctgcgg gagtgggggg cacgcagggc accccgcgag cggcctcgcg 1200 accaggtact ggcgggaacg cgcctagccc cgcgtgccgc cggggcccgg gcttgttttg 1260 ccccagtccg aagtttctgc tgggttgcca ggcatgagtg 1300 <210> 95 <211> 500 <212> DNA <213> Homo sapiens <400> 95 tgcgatcatt aaaatcagtt ccttccctcc tgtcctgagg gtaggggcgg gcagatttta 60 ttacttctct tttcctgata gcagaactga ggcggggttg tggaggagcg acggaggacc 120 acctctaact tcccttcact tcctggattt gaagcctcag ggccaccggc ctcagtcctg 180 ttacggtggc ggactcgcga ggttttccag cagctcattc cgggacggcg gtgtctagtc 240 cagtccaggg taactgggct ctctgagagt ccgacctcca tcggtctggg agcgagtggt 300 tcgagttcag atgctgggaa ccgtcgcttc tccccggccg ggctcgctgt tttctcctcc 360 gctcgccgtc atcaagcccg gctatgagca gggctttaaa tcctccctcc ctcacccgca 420 ggtttaccga gcagccccgg agctctcaga catgctgcgc tgcggcggcc agaggagggg 480 tgggggcatt gccctctgca 500 <210> 96 <211> 500 <212> DNA <213> Homo sapiens <400> 96 gggcttgggc cgcaggcttc cctggacttc cgcagtcccc cttctcccca ttccagaacc 60 tgccgagccc ctgctgcatc tgggacccgc cttcaccgtt tcccaatccc agcggttagc 120 ccctgcgccc cctttttggt ctccactttg ccgttcgaaa atgcctaggt tggtggatcg 180 accctccgcg gagcaaagac ggatggctgg caggagcagg ttcaggagct gggccaaggt 240 attctctgct tccgcctttg tgtccgcccc cccgccccct gctccccgct tcccgccagc 300 atctctcctt ttctgctcag gagtgtttgg cccggcggtc caccccggct tcccgagata 360 cgctagagtt gcccccacgt cctgtccgcc gcgcccctac ccaccgggtt gccttcgggg 420 cccttcggtg ctgtgtagtc ggcgtggcgc tgtgagctag gcgaacagga acccccaggc 480 ccgccacgtc tacgctatta 500 <210> 97 <211> 600 <212> DNA <213> Homo sapiens <400> 97 ttctggggcc tggatgggtg cgagcgggac ccgggggagt gggagtcgcc aggctctgag 60 caagcaaggg ctgcacctgc acctctgccg ggcatgaaga aaggtaagga aggaaggagc 120 tcacccgggt gggagacaga gccggggcgc gcgagcttgg tgtgggggcg ccactccggg 180 gcggagggga ggggctacca gtgacttctc cgagtcggga gctagaaaga ggcttccggc 240 caggttccct tggaacaggt gtcggagttg ttgggagagg gggctgcaag aaagaggggt 300 gcagaaactg gttcattaga tggaggctct gggcggaacc gcgaggacac cctggcagcg 360 cgctgtgcct gcgttaggcc gggaggggag aggcctccgg acggcgaagt gtccctaggg 420 acccagacgc ctcgggagcg atccgggccg ctgcgaagcc ctgcccacca ggagtggatc 480 cccaggattc acctcccggc tgcctgctct gagctgagaa ggggatctgg ttcttcacaa 540 taccgtggat ggcggggaag gggagggagc ctggggtaaa atcccatctt ggtttcctcg 600 <210> 98 <211> 1300 <212> DNA <213> Homo sapiens <400> 98 tgtcacagaa accccagcag cgcagccacc ggactgggtt ctggaggccg agccgcagtc 60 cgtgcggcgg cgctgggaag agaaggcgcc ccggcagctc ccctgccacc ggccccgagg 120 agcggctggc tcccccagcc cagcgccgcc gccgcccggt aactccaggc gcaactgggc 180 gcaactgggg cagctgcgac accgaatccc tcacatctgc aacctgggtg ctgcggccac 240 tgagaaaatg gaggcgcaga ccaacgagcg gtgccgcgac cgagagacct cggctggcga 300 aatggtggtg ccgggagcct gcgagtgacg ccagccggcg gggttgtcaa ggacaacatt 360 cgttttgacg cagccaatgg cgccgtcacc aagaaaccat cgactctgag aaaaaagaga 420 ggttcggcca ccgagaaact ccgtacgaca agtgctgtgg cagaaaaacc gcctactccg 480 cgccacaggc aaaacagcca atggaaaccc caggtgctgc gaccgtgaca ccggcactag 540 agggtctcgg atggagaaag cggcgcacgg agaccaggaa actatgtgta gcacaactag 600 cagaaaaccg tctggtcggc catccgggag aaagcgcgga tcagaaacaa gcgacttcga 660 tgcagggaac cgcgcagcca ctgaagaaag tgacccacgt ggcagtggtg ccagcgaaac 720 actgcagttt ggacggcagc tgtggggatg ccacagagaa acatgcactg ccactgaagt 780 acatccagct ccgcggagct agtgttcata tgatcaagaa accgccagtt gggctctgct 840 agaaactttt agtcctccct taacggctat cctacccaca acagacaatg cctttaccca 900 gcacctagcg gtgctgagac ccgcctgggc cagcacagag cgcagagcag tacgggtacg 960 gagaaacgcc ggactcagtg aaaccagcct tgcctccagc ggattccccg gcttcgccgg 1020 acgccacagg cagagtgccg cggggaaacc tctggctccc taaaccgatt agattgtggg 1080 agtggggggg acactcacaa gttgtgtgga agggaaccag cggcaatggg acccggcgag 1140 cacttgcccg cagcaaatgc ctgcgctgct gcaaaaaaaa caacttttgg cgcaaagaat 1200 gttgcggcca gagagcatcc gctgtcgctg acaaaggagt agcaatggca atgagaaacc 1260 gccggcgcca cggccgaccg cggcggctca cgcctatgat 1300 <210> 99 <211> 2100 <212> DNA <213> Homo sapiens <400> 99 caaacgctga gagacaaaaa gacaccaaca cccaccagga ctgcgtcctg ccagctcttc 60 actccgctga cctgaccttc cacgccccta gtcctcgagc ggacttgacc tgtgggggag 120 taccgaaccg tccccatgag gccctccaag cggccaggtg gcctccgcca ctctctccac 180 ccccacctcc tccacccccc agcccatcgg tccatcttcg atctgcaaaa cacgccgggt 240 cagcgacgca tcggtcccag gcttgtgacc acctctttct ctgttacttg gggagccagg 300 cccaccgctc aggatcacag tgaggagaaa aaagacacaa acgccaggac agggcggctg 360 gggaaggaaa ctgctaggga ccgctcattg tcagcctggc gtgtcccacg gatcgcagga 420 cccgtcgagg ctttgctctc tgcgacccga atactcctgg gcctctcgac ctcctcctcg 480 gactcaggcg tccgcgtctc cggtcatcac gggagaccaa ttggtttaca aatagtgatg 540 ataaacctgg gaccgacctt ggggctgtgt aaaagtctac tgacagatgt aatggagggt 600 tgttagcagt cacaaagcct gtcggacccg tagcattagt tcaagagact attttcgtgt 660 cgcaccaaaa ttactgcgcg tgtaaaccaa tttccccgac ggaagaataa acagagattc 720 gtttgaagcg cgagatgaaa acagatgggg tatcgcaaac agttccccaa aatacaacag 780 acttctgggc caattacacg tggttagctc tgaatggcag aggaaatagt tttctttgct 840 gctaaatgtc acaaaagtca cctaaaggca cagaggaggc cgctctgttt ttgcgaaact 900 tgctaaaatt aatctgcgct gggccacttg cagaaagcag aaccacctcc cgcccccacc 960 tcgcctccag ccgccggggt tcaggcgttt gtgaaagaca gaacctttgg gctagggacc 1020 cgggcactgg tgcttcgaag tccgaatccg ccggccgaga aaacgacaag agaaagaaaa 1080 tccagcgggc gctctctcca gcgccaggcc ggtgtaggag ggcgctgggg ctcggcctgc 1140 cacccctacc cgacattggg aagcagcccc tgcgctcccg cggcgcctca gcctccggtc 1200 cccgccccga ggtgcgcgtt cctcctcccg catgcccgtc tcgggcccca cggagcaaga 1260 agatagacga tgacgaggcg cgcccatcca tccgggccga cgaggtcagg cccgcgccac 1320 aggcaaaaat tgcgcaagcc cggccgcagg gatttcgcgg gcgcctgggt cccaggtgcg 1380 cggccgaaat cctcagggaa aatcccgagg ggccaacggt ctaggccaca gggctgctgg 1440 gcccgggcct ggctcagagc gcattcgggc ggggaggccg cacgccgcac ccgggcctct 1500 cctccgagcc cgaggcaggc actgagctcc gggccagcca ggtgcctccc ggctggtgcg 1560 agaccccggg cctgctggga ggcgtgggca gggcagggca gggctgaacc ccagcgactg 1620 aatctcgaag gcaggaggcc tcggaggtca tcggcccagc tcgcctgaaa ctgtccctgc 1680 tcgtgccagg gcgcgggcag aggagaaagg acagggcgga gcaagcccac tgcagaactg 1740 cggtcggtgg ctgcgaaggg tccgggtcac cgcgctcccg gacgccggaa gccgcgctgg 1800 cggggccgcg gggagggagg ctgggtaccg gggccgtccg gccggaggaa gcggctccgg 1860 ccgcgctgtc cgcgcttggg agccgcgtgc agggttcagc cgtgtttcag ttgccctctg 1920 acctgacccc gggcgcacaa aggcctcccg ggtgcgccgc catggcccag tcttccagtc 1980 gctgccaaat taatgagccc acgtcaggtt gggtttacag ctcggccggg aagcagccga 2040 gtggaaaatg agctcggggc cgctccagag gctcccgcac aactgcagag gctgcccgcg 2100 <210> 100 <211> 250 <212> DNA <213> Homo sapiens <400> 100 tttccaagac agaaggaggg aactaggcgc cttttttcca ctccgctgac cccaacgtct 60 gggctgtgcg ttgtaacgca gttggcgggg ccttcagctt gggatgaggg cgaaggggct 120 cgggatgggt gggaaagcaa ggaccgggca acaggtgggg aggtggcgga cttttgtctc 180 ggggaaggaa atcggctgtg ctgaaagggc ggaaagcagt agcgcacaga actagtgtct 240 gcggggtccc 250 <210> 101 <211> 250 <212> DNA <213> Homo sapiens <400> 101 ccctcctgtg gctgcttggg cagacgcctg tggcctgtcg gatgcggccc acatcgagag 60 cctgcaggag aagtcgcagt gcgcactgga ggagtacgtg aggagccagt accccaacca 120 gcccagccgt tttggcaaac tgctgctgcg actgccctcg ctgcgcaccg tgtcctcctc 180 cgtcatcgag cagctcttct tcgtccgttt ggtaggtaaa acccccatcg aaactctcat 240 ccgcgatatg 250 <210> 102 <211> 2000 <212> DNA <213> Homo sapiens <400> 102 tcctcctttg tgtatgtcaa cccagaggat ggacggatct ttgcccagcg tacctttgac 60 tatgaattgc tgcagatgct gcagattgtg gtgggggttc gagactccgg ctctccccca 120 ttgcatgcca acacatctct gcatgtgttt gtcctagacg agaatgataa tgccccagct 180 gtgctgcacc cacggccaga ctgggaacac tcagcccccc agcgtctccc tcgctctgct 240 cctcctggct ccttggtcac caaggtgaca gccgtggatg ctgatgcagg ccacaatgcg 300 tggctctcct actcactgtt gccacagtcc acagccccag gactgttcct cgtgtctaca 360 cacactggtg aggtgcgcac agcccgggcc ttactggagg atgactctga cacccagcag 420 gtggtggtcc tggtgaggga caatggtgac ccttcactct cctccacagc cacagtgctg 480 ctggttctgg aggatgagga ccctgaggaa atgcccaaat ccagtgactt cctcatacac 540 cctcctgagc gttcagacct taccctttac ctcattgtgg ctctagcgac cgtcagtctc 600 ttatccctag tcaccttcac ctttctgtca gcgaagtgcc ttcagggaaa cgcagacggg 660 gacgggggtg gagggcagtg ctgcaggcgc caggactcac cctccccgga cttctataag 720 cagtccagcc ccaacctgca ggtgagctcg gacggcacgc tcaagtacat ggaggtgacg 780 ctgcggccca cagactcgca gagccactgc tacaggacgt gcttttcacc ggcctcggac 840 ggcagtgact tcacttttct aagacccctc agcgttcagc agcccacagc tctggcgctg 900 gagcctgacg ccatccggtc ccgctctaat acgctgcggg agcggagcca ggtgaggggc 960 tcggcgccgc cccgggcgac ccctgggggc ggcactggag aagccgcccg tcctcataag 1020 ggattgaact tgcatccact cctctccggc cggcttggtc gctggctgcg ctccacccga 1080 ttctcgggat cattggaccg tttgcgcgaa accagagtgg ccgattaagg gatggggctc 1140 cgagcaccgg gggtggtggc gactgtgggc gaggggaggt gggaccgacc cccaccccta 1200 cactcaaaaa aggccggggc ctccttcgag cttccggtga atttcgggcg atttccgcgg 1260 gtgtcggggg tcccgggagg aggcagtcac agatccaccc ctgcagccag cctcctaggc 1320 gccggctccg gcacgcttcg ccggtctgta gatttcctct tcgatttctc cccagctccc 1380 agcatctgtg acttcactgt taccctccct atccccgcat cacccaaccg cacctgtctg 1440 cgggacttag gtgtgcgcgc ggggctcatg cgtgtcctcc ctgctggcca cccccacggc 1500 ccacacaagt tgcacgggct cgccacgccc cgccaacacg tgcgcggacg cacgcacgca 1560 ctcctcgcac gtgggcttac gcgaatacca gctttcactg ccactcgctc gcggccagat 1620 tcacaggcct gttccggtcc actcgcagct cccctctgcc gctccctccg ccgggctcag 1680 gagtactcgt agctgattgt gcgcgcctga gggtcccaga tcgcggccgc ccaggaccag 1740 gcgaggactc cggagcctcc tctcacctct cccacctgcg ccccgggctg ggccgggtcg 1800 cctggggggc ggcctgagcg aggcgcgggg ccaggagcgc tggagcgact gccgctctaa 1860 gtgccgggcg ggcaggactc tacgatcctt gggccagagg tccggatggt cccgggactc 1920 cgtctcaagg gtcggcgacc cctcaaccca gaagcctcga gcaggcggac aggcagagct 1980 gcccagtggc cgaggcgcgg 2000 <210> 103 <211> 1100 <212> DNA <213> Homo sapiens <400> 103 atttgtcgtt gtgccattgc tgccactgtt gttcttgtcc agggaaacac cggtggccaa 60 cccagatcgg atacaatggt gcggctctgg actgagcctc caaccacatt agccatgggc 120 agcattgttg ctgccgctgc tgttatttta attatgattg tacgttaacc accaccttcc 180 ttcctctgcc tcccttcagc tgcaatgatg tatgttactt tttggtaact ggatttcatt 240 aacatttatg aactctcata aagtagtaga aaaagcaatt tgtgtggaag aattttccac 300 ctcattaaac agtgttcttt tgggggtcaa gctgatattt tttttgttgt tagatttttt 360 ttataggtcc tttgtccttc cctaagccct gggggatgaa aggagagccg tccacccagc 420 gaggggcttg tgtgccctag agggcgctgg gccccgcgcg ctttcctggc tgtccccgcc 480 ggctttccac cctccccaaa gcccaggtgc ccaccgtggg tcgctgcggc ctttcccctt 540 cttggccaaa tccgattact tcgcagcctg cagatggcat cgccggctaa gggcagcctg 600 cggcaggtcc ccgagcctga gcactcctcc tatctggggc ctgagaggac gctctgggct 660 ttttcccagg cccagggtgc gcggcctgct agcgcctttc gaggcacagt cccaagatag 720 gctcttgtcc ttcgacgccc ccttggcaca agcgcactgg cgccctccgc tcaacccacc 780 ttgcctttgg ggcgggcttc aaccctggga agacaggcct gggggaagcg agaggagagg 840 cccgaataga ggttccggct caatctttcc cagacggagg cctggtgttt ccagctcagt 900 tgcatcttcc agccgcgggc tcctggccca aacagaatgt gtttgctttc acaccgggac 960 ggcaagcgga gtccgcctca gtgagcagcg agctgcgcag tccggacggg tgtcgccccc 1020 agagactcgc cagccgcccc cagacactcg ccagccgtcc ccatctctaa tccaccgtcc 1080 aggcccgggc cctgggaaga 1100 <210> 104 <211> 800 <212> DNA <213> Homo sapiens <400> 104 ccgtgtctcc cttaagaact ggggcctcat ctccactcca gctgcgcgtg cacgtgtgct 60 cccggcagga cgcgcgccca ggagcgcgct gggggctgcc ccgcccctct ctccctcccc 120 cgcgggtaaa ctccgggcat ccatcagtct gttaattgca ctaattagag atcgcagagg 180 tgttaattgg aaaaccctgg tattgtgcct gtttggggga agaaaacgtc aataaaaatt 240 aattgatgag ttggcagggc gggcggtgcg ggttcgcggc gaggcgcagg gtgtcatggc 300 aaatgttacg gctcagatta agcgattgtt aattaaaaag cgacggtaat taatactcgc 360 tacgccatat gggcccgtga aaaggcacaa aaggtttctc cgcatgtggg gttccccttc 420 tcttttctcc ttccacaaaa gcaccccagc ccgtgggtcc cccctttggc cccaaggtag 480 gtggaactcg tcacttccgg ccagggaggg gatggggcgg tctccggcga gttccaaggg 540 cgtccctcgt tgcgcactcg cccgcccagg ttctttgaag agccaggagc ctccggggaa 600 gtgggagccc ccagcggccc gcagactgcc tcagagcgga agaggcagcc gcggctttga 660 cccagcttcc ttccgacggc atctgcagga gcctctaggc ctgacatagg ctccgaggtg 720 ccctggctcc cccacgggga atgctgaggg ttgggccact aggtcctgcc taagtgcagg 780 acctgagcct cagacaaatc 800 <210> 105 <211> 300 <212> DNA <213> Homo sapiens <400> 105 gggattgccg gctttgagaa aatatgaaga aaccgatttc tccttccact ttgccagtgc 60 actttccttc cactttcact ggtgctgggg gcggcgcact ctttacgaca tataagcgga 120 aaattctgca aaagtggccc ccggggatcc ccgcccgacc cctgtctgtc gctaatgtgg 180 gcctgtctcc ggaaattcga ggttgggcct ttgcctgaat ctgttgctat tgctcccctt 240 gctaccgctg acacttggca ccgccgcctc ctagcagcgg ccagacgcgg ggctgggggc 300 <210> 106 <211> 400 <212> DNA <213> Homo sapiens <400> 106 gttgcgagcg cggcacaggt tgctggtagc ttctggactc tggaggcttg gccttccttc 60 taagccgatg gcggggaaag aacctcgttt ccacagcttc cccgaccccc gccgcttgcc 120 atttggggac gggaagcgcg cccgggtcgc ttcacgtccc tctgggccgg agccctttcc 180 atggctggct cctctggggg cccttgggcc tgtgagcagc gtctccttcc ctcagagaag 240 aatcctttcc ttcccccatc gaagtgtccc tttctgtatc ctgaaataac ccctcctggg 300 tgaggccagt tcccctctgt cgccctcctc ccgcaggcgt ccgggagcct cgtgaggacc 360 ccgtgcagtt gagtccaggc gacaggtgcc tccccaggtg 400 <210> 107 <211> 800 <212> DNA <213> Homo sapiens <400> 107 cagtgcgccc cttaccggag cacccatggc ctcccgcgtt accccaaatt ttgtaggcag 60 actgtcagag ttcgaagcca gctgtgtcct ctgcgggccg tgtgacccta ggctatctgg 120 gctgctcgga gccttagttt ccctagttgt gaagagggag ggtgtgacca tggcccggag 180 ctctccgaaa ggctgtgcgg attgctcggt ggcgggatgt ggagcgcgtc ttctatgatg 240 ccaggtgctg gccaagcgct cgatgcaggc tgctccagtt aggtcgatgc gatggcggga 300 agcactttcc tctgcaatgg agagacgccg acaccccgag cccgaaggct tgcaaggcgc 360 gctctcgcca ctggggtcgg ggatccgtgg gttctctatc ccgcttaccc actccatcct 420 tagcagctgt cgtcggtccc agacctctac cttggagaga ccaaggcggc ccagagccca 480 ggagactact gcgcggtacg ccaggatcca gaagtggatt ctgacttcta aagacccctc 540 ccaagccaac gctatcaggg tccctgcaag cggttgactg tggcggaggc agaaccaaaa 600 cctttgctct gcccgcggcg ctccagcctc tcacccagga cagtgctctg ggctccagcc 660 gctgcagtgg ggtcgggaca cagacgccga gttagaagcc ccgccgctgc aggtccctgc 720 ttggtcggcg cggtgacggt gtcgctggcg gcggcggggg ccttcctttg gctgcccggc 780 catttaatca gagctattat 800 <210> 108 <211> 1000 <212> DNA <213> Homo sapiens <400> 108 tttagtattt aaggagaaaa gcctcatttt ccagaatcga ataagcgaat taatcgcaca 60 attgtgtaga atggaactca gtctgtaaaa aatcaagacc aacgtacttt ttaatattct 120 aacatctcca agtagtagtt acaagtattg tacccatgaa gtccaggtaa ttaatttgtt 180 caatgtcaca ctgttaaaag tcaggtgggc tccaaagcac agtcctaacc agcatgctct 240 actgcctcct ctgaggcaac agccgaagtg cagaccactg ggaataaata gctgcccggt 300 cttccccact cctaaattct cccgacagac cccaaagcct ctctgagagc ctctctgacc 360 gccctgcggc ccaccccgag ttcccggcat cctctgggat ccctcttcct ggagccaaaa 420 cctacgcagg ctcctttcct ccgagctggt tgctaggtga tctccgaagg ctgtccgaag 480 tctcgcgagg gcggacccgt tgcctgatga cgagagttgg gagtgtggct ggggctgcgg 540 atctccagca gtggcgttac ttctagcggc tggataccgg gttctccgcg agatcgcgag 600 atcccgagat attctccccg cacggaagcg acgactggcc tggccagagg actcgcgtgg 660 gagcgaggtg ccggccccga caggacggtg aggtatgcag aagtaaggcg gggcgccccc 720 tgcgggaagc gagcgcgccc cggaaaatga gcgcctcccc acaccaaggt gtccaggagt 780 gagtgcggga aggaactcgg ccgcccggag ttgtggcctc atcgtgcttc ccgccaaaaa 840 cgccttggta ctgtcgggac gcggctaagc gtggacgcgc ccgcatctgc ccctcctccg 900 cagtggtgga agacacccgc ggagcgccgg tggataaggg ccgtttcctg agaccagagc 960 tgtatccgca gcaggtcagc acttcgtgcg ccctgtgtgc 1000 <210> 109 <211> 300 <212> DNA <213> Homo sapiens <400> 109 agcggcgctg ttcccgggct gggtgcagct gctaaggaca aggcccctgc tccgaagaac 60 gcggtggctc ggggataccc tgaaagggac ggccatggcg cacatgggat gccctagggt 120 tcgtgggagg gcatgcaggc gcagcccccg caggggttgg cctgccagag aaggcagggg 180 agagcactcg gggctgcaca aatggtgtgg ccggagggaa ggtgcagcct tgtgtgtgtc 240 tggatgaggg ctgggcatag gagcttggta tttgatcctg aaagctctgc gtttccaaag 300 <210> 110 <211> 600 <212> DNA <213> Homo sapiens <400> 110 gagtcatact tgtagtcaca tccttttcct ttctccaacc cactggttaa tcatgaaagg 60 ctcttctgat tggctgcctc ctggcagtag tgcctcagcg cgacggttcg ggagcaaata 120 aataattccc gctgggaagc tgtttctcag acaggagcag cgacacccct gccacgcctg 180 ccgcctggag ttgagtgggg taagcacgcc ggcctccagg aatcgacggt gccacgtggt 240 tcttcttgca cttctcttct tctccagttt caggggacac cgtggggtgt gcgagcccgg 300 gggagcgcag ggaagggcgg gttgggctgc aggtgggaat gtgcggtcct tctgcgccct 360 caacagagct tccttccttt ttgccaaggt ccccgtgccg ccttcagcgc gcctccttat 420 gcacctctac ctctgctgca gcgtacctct tccgcagccc tagcggcctc cccgaggggc 480 gccgcggcct cggctgtccc tcccctgcct ggcacgacca cctgaccccc agcgacccaa 540 gaagcaagtt gtgtttgcag acgcaaaggg gctgtcgttg gtatcggtgc actggtttga 600 <210> 111 <211> 1700 <212> DNA <213> Homo sapiens <400> 111 acactttctg tgtgggaggg cacaagacat gggctatgac atggccagag accccacctt 60 ctttacacat gtaaaaacca accaaatcaa gatgcgtcaa cggtgattct tcctcccaca 120 ttgtttccct ttttaaactg ttattttttc aatccatgga gcagttgaga aacgggtatg 180 catctctcct cccctcccct tctatcaaag cctgtaagac acataaggaa atccaaagcc 240 acagtaatag agagagagag agagagagag agagagagag agagagagag agagaaaaca 300 gaacaaaaga aatcctcctt ggcttgtttt tccagggtgg ccaggcaagg tgtgaaaatc 360 catatttccc tctgggctgg caggtagaag ttactgggaa ggctgcgctc ccttctctcc 420 caccggctct cacatccagg ctgttccctc accctcagcc tcccccagcg ccagcttcct 480 cctccgcctc tctgcagcca ggcctcccct gcaaggcgga ccttggccca ccttggttcc 540 gggccaaggc ggcgggaaag gcaccgctac ctgcagccgc acgactccac caccatgtcc 600 tcgtactgct tgtagaccac attattgccc gcgtcgatgt atagaatgct gatgggagtc 660 aatttggtgg gcacgcagca gctgggcggg gtggagccgg ggtccatgga gttcatcagc 720 gtctggatga tggcgtggtt ggtgggctcc aggtgcgagc gcagcgggaa gtcgcataca 780 ccctcgcagt gataggcctc gtactccagg ggcgcgataa tccagtcgtc ccagcccagc 840 tccttgaagt tcacgtgcag gggcttcttg ctgcagcgta gcctggactt cttgccgtgc 900 cgcttgccat ggcgactggc gaaggccgtg cgccgccgcc ggcggccggg cgagggcagc 960 caaggcctgg catccggggc gcccgacggc ggcggccacg acccctcggc gcccgcgccc 1020 gggcccgcag cctcggccga gcccagctgc tcgcgcatct ctgcgaacag gttcttgcgc 1080 tgggatctgg tgaataccac cagcagggcc cgctcctggg gaggccgcac cctccggccg 1140 aagcccagac tccgcaggtc cgggggcggc ggttgctggg gtccccgcgc gcgcgcctcg 1200 gcctccccgg cgtccagctc gccccatgcg gcccgcagct ccaagcacag ctgcttccag 1260 ggctggtggc gcaggccctg ccacacgtcg aagacttccc agccggccgg cggcgccccc 1320 tgcgggtcca gggtccgcgc gtccagcagt aggggcgaaa ggcaagggaa gagctgcacg 1380 tggagcggcc cggctggtgg cccccagggc gctgagggcg cctggcgaaa gagccgcagc 1440 tccgcgccca ccagctcttc tttgtctgag agcatggaca catcaaacaa atacttctgt 1500 ctccggagag gagtgtgcga gagatcgtct gcgagataaa aaataattac agtcagtttc 1560 acttaagggg gagatcagcc cggtgctctt cggccgcccc gggaggaaaa gggcggggag 1620 tgggggcagg tcggccgggc agtccagctt gcccggccca gggcctgacc accccggctc 1680 cccatctggc tggtgcatgg 1700 <210> 112 <211> 2000 <212> DNA <213> Homo sapiens <400> 112 gcccgctgtg aatgtaggtg aggtgatccc gggaacctgg gtctgaaatc agacctgtgt 60 tgccattggg agcacggaga gaggggaagc gccctgctta ggcccaggcc gggcgtcctg 120 gtggtgggac cgcagccgca ctcacctcca ggccaacgga caaggttcct gcaagccagc 180 agggccactc tgtgcttggc ctactgcagc tcccctgcag ctcctttcct ctccctcccc 240 ggagcgctct cctctctcct ctcccctctc ttctctctcc tctctcgtct cctggggcat 300 cccgggtgga gggatgtagg ggtcgctcct cggtgccagg ccgggaagca gctcaggcct 360 cccaagagct tggcgctcag tctgggaaaa ggggttcctc tggcctcagg gacgttctcc 420 gcccccaccc caccccctgg gagcctgaac catctggaag ggatcttagt cgggggttgg 480 gaggagagcc cgtggatagg aggagggggc gattctaggc cgaatccagc ccctgaggtg 540 tcacttttct ttcctgcggc ccgtcaccgc tgatagatgg ggctgagggc agaggaagga 600 aaaagaaaac ctccgaggtc agtgcggggc gaggtgagcc cctcccaggg ccctctggcc 660 caggaggatg aagcgcgccg gcttcgctct tgcacgccgg cttgccatcc gggtaagcgc 720 gggaaaggcg gccacagggc gcggcggcag cgcagcgcgt gggatctcac gacccatccg 780 ttaacccacc gttcccagga gctccgaggc gcagcggcga cagaggttcg ccccggcctg 840 ctagcattgg cattgcggtt gactgagctt cgcctaacag gcttggggag ggtgggctgg 900 gctgggctgg gctgggctgg gtgctgcccg gctgtccgcc tttcgttttc ctgggaccga 960 ggagtcttcc gctccgtatc tgcctagagt ctgaatccga ctttctttcc tttgggcacg 1020 cgctcgccag tggagcactt cttgttctgg ccccgggctg atctgcacgc ggacttgagc 1080 aggtgccaag gtgccacgca gtcccctcac ggctttcggg gggtcttgga gtcgggtggg 1140 gagggagact taggtgtggt aacctgcgca ggtgccaaag ggcagaagga gcagccttgg 1200 attatagtca cggtctctcc ctctcttccc tgccattttt agggctttct ctacgtgctg 1260 ttgtctcact gggtttttgt cggagcccca cgccctccgg cctctgattc ctggaagaaa 1320 gggttggtcc cctcagcacc cccagcatcc cggaaaatgg ggagcaaggc tctgccagcg 1380 cccatcccgc tccacccgtc gctgcagctc accaattact ccttcctgca ggccgtgaac 1440 accttcccgg ccacggtgga ccacctgcag ggcctgtacg gtctcagcgc ggtacagacc 1500 atgcacatga accactggac gctggggtat cccaatgtgc acgagatcac ccgctccacc 1560 atcacggaga tggcggcggc gcagggcctc gtggacgcgc gcttcccctt cccggccctg 1620 ccttttacca cccacctatt ccaccccaag cagggggcca ttgcccacgt cctcccagcc 1680 ctgcacaagg accggccccg ttttgacttt gccaatttgg cggtggctgc cacgcaagag 1740 gatccgccta agatgggaga cctgagcaag ctgagcccag gactgggtag ccccatctcg 1800 ggcctcagta aattgactcc ggacagaaag ccctctcgag gaaggttgcc ctccaaaacg 1860 aaaaaagagt ttatctgcaa gttttgcggc agacacttta ccaaatccta caatttgctc 1920 atccatgaga ggacccacac ggacgagagg ccgtacacgt gtgacatctg ccacaaggcc 1980 ttccggaggc aagatcacct 2000 <210> 113 <211> 2000 <212> DNA <213> Homo sapiens <400> 113 cactcccccg ccgcctccgc ccctaaccct cggccccgtg cgcgagcgag cgagggagcg 60 aacgcagcgc aacaaaacaa actagtgccg gcttcctgtt gtgcaactcg ctcctgagtg 120 agtcgggggc cgaaagggtg ctgcggctgg gaagcccggg cgccggggac ctgcgcgcgc 180 tgcccggcct ggccggagcc tgtagcccgg gggcgccacg gccgggctcg cagtcccccc 240 acgccggccc cccggtcccc gccgagccag tgtcctcacc ctgtggtttc ctttcgcttc 300 tcgcctccca aacacctcca gcaagtcgga gggcgcgaac gcggagccag aaacccttcc 360 ccaaagtttc tcccgccagg tacctaattg aatcatccat aggatgacaa atcagccagg 420 gccaagattt ccagacactt gagtgacttc ccggtccccg aggtgacttg tcagctccag 480 tgagtaactt ggaactgtcg ctcggggcaa ggtgtgtgtc taggagagag ccggcggctc 540 actcacgctt tccagagagc gacccgggcc gacttcaaaa tacacacagg gtcatttata 600 gggactggag ccgcgcgcag gacaacgtct ccgagactga gacattttcc aaacagtgct 660 gacattttgt cgggccccat aaaaaatgta aacgcgaggt gacgaacccg gcggggaggg 720 ttcgtgtctg gctgtgtctg cgtcctggcg gcgtgggagg ttatagttcc agacctggcg 780 gctgcggatc gccgggccgg tacccgcgag gagtgtaggt accctcagcc cgaccacctc 840 ccgcaatcat ggggacaccg gcttggatga gacacaggcg tggaaaacag ccttcgtgaa 900 actccacaaa cacgtggaac ttgaaaagac aactacagcc ccgcgtgtgc gcgagagacc 960 tcacgtcacc ccatcagttc ccacttcgcc aaagtttccc ttcagtgggg actccagagt 1020 ggtgcgcccc atgcccgtgc gtcctgtaac gtgccctgat tgtgtacccc tctgcccgct 1080 ctacttgaaa tgaaaacaca aaaactgttc cgaattagcg caactttaaa gccccgttat 1140 ctgtcttcta cactgggcgc tcttaggcca ctgacagaaa catggtttga accctaattg 1200 ttgctatcag tctcagtcag cgcaggtctc tcagtgacct gtgacgccgg gagttgaggt 1260 gcgcgtatcc ttaaacccgc gcgaacgcca ccggctcagc gtagaaaact atttgtaatc 1320 cctagtttgc gtctctgagc tttaactccc ccacactctc aagcgcccgg tttctcctcg 1380 tctctcgcct gcgagcaaag ttcctatggc atccacttac caggtaaccg ggatttccac 1440 aacaaagccc ggcgtgcggg tcccttcccc cggccggcca gcgcgagtga cagcgggcgg 1500 ccggcgctgg cgaggagtaa cttggggctc cagcccttca gagcgctccg cgggctgtgc 1560 ctccttcgga aatgaaaacc cccatccaaa cggggggacg gagcgcggaa acccggccca 1620 agtgccgtgt gtgcgcgcgc gtctgcgagg gcagcggcgg cagggggagg aggaggcaga 1680 ggcggggtgg ctggaccctc ggcatcagct cattctcccc tgctacacac atacacacac 1740 aaataatgtt tctaaaaagt tcagttgcga ctttgtgcct cgcctgtcct gttcatcctc 1800 gtcctgggcc ggggaatgct tctgggggcc gaccccggga tgctggctaa ttgctgccgg 1860 cgggttccgt cgccggtgtg accctggacg gcgcggacgg cgtacagggg gtcccgggag 1920 gggcagtggc cgcggcactc gccgccggtg cccgtgcgcg ccgcgctctg ggctgcccgg 1980 gcggcgcagt gtggacgcgg 2000 <210> 114 <211> 800 <212> DNA <213> Homo sapiens <400> 114 ctgaaaagcc gtcagggaaa ccacacatgt tcaacccctg gcggctcccc caaacctctc 60 atttccagta actgtgtgtt tccgctcgtc aacagctgaa accgagcgga acttgggggg 120 ccccaccacg cggccctgct gtgcggcacg gggctcatct gtcccccggc tgcggggagt 180 cagctctcac cgcccacctc cttcccagat agtctctgtg cccactcgac ggcccggcaa 240 gcccagcccc tgcctgccac ggccacagca gcctcagaga gctgccctct ctggccaggg 300 tcagggcctg agctgctgcc tcccgcaggg tcgagggcag gacacttgtc tgaggcttgg 360 gtggggcaat ggcacctcct cagggcctca gcccccgggc aggctcggtg accatgggcc 420 tacagcaggg aaaattctgg gccaaaagct ccagcctcct actagggcat ctgtctgcaa 480 atgcacctta acctgaccgc ttgggctgtg ggggagcctg tttcagggaa agtgagggac 540 gcgccagttt cctcctttgg acttgatgag gcacgaacgc atctctaata aagccaggtc 600 tccccgccgt ggctccctgg gcgggtgcct gtggctcggg ccatgagtca cgctgggtaa 660 ccccactacg gggaagaggg caggaagctg ggagccaccg cctctgtgcc cggttgtcat 720 ctcggcacga gggcgaccgt cggcttcgtc ctgccctcat ggctgagggc ttttgggatg 780 tggcgggaga cgggggagtc 800 <210> 115 <211> 500 <212> DNA <213> Homo sapiens <400> 115 aaatcatcag aatggctaaa atgaaaaaga cagacaacag caagtgctga caagggtgtg 60 gggcggccaa atgctcctgc actgctggca ggggacctga gaactgcagg gcattccctg 120 gcttcctgcc cctcctggga ctggggaccc cccagggaca gcctaaggga actgcattta 180 tcttcacgtc tgccaaaaga taacacgaag atgttcaaag ctaagccccc aggctggtaa 240 gagctccaag gcaccagcag tgtgtgcaga actgggggga gtctgttctc ccagggatgc 300 tcccatcacc tgctgccagc agtggggcat gccggtcccc tggggtgtgg ccaaggggct 360 gtgtctcctg cccgggctgc cggcccctct caggttcact ttcccatctc taagcccacg 420 tctcgctgca gttcaagttt gccaggccac caacgggtga cacgcccggc gcagtggggg 480 actccgcact ttctgcgcac 500 <210> 116 <211> 1200 <212> DNA <213> Homo sapiens <400> 116 accctttgtg cctgggtccc ataaacaatg tgctttttaa aggggagccc cctcccagct 60 ccggcctttt tctccagcgt gggcagccaa tcagctgcgc agagctgcat agctggaccg 120 ctttccattc tgagtagcaa caacgtacta atttgatgca cacatggatg cctcgcgcac 180 tctgcaaatt catcacccgc atcttgcatt agtcatctga cggactgcca agtgtttcat 240 tttctttcca tgtgacttta ttattaccac ctctctcctc tcttccaaaa acctcccaaa 300 aagggcggtg gggcgggggg cggggcaggg agagggagag aaatccagca gacatctagc 360 tctgcctttc tttcccagcc acagccaggg tagggctgat aaggcgctga tgcgttgatg 420 gcagccttgc agagctagac ctgcacttaa cttgcagctg cctcccgagc ctccaagatg 480 tccacgccct gggtgacagg cggcagggcg ctgccccgtg ctcccccggc tctgctcgac 540 agcagcacgc agtgagagcc tcgccgccgc cgaggagcaa ctcatggtgc ctccgctttg 600 ttttagttca tcaaatttct acgactcatt aggcactttg ccactgctct tcttcctcct 660 ccttccgcct ccccgctccc ccacccccac tattttttct tcctgtccct catcgtgccg 720 ccctaactct ggctcccggt tccgtttttg acagtaacgg cacagccaac aagatgaacg 780 gagctttgga tcactcagac caaccagacc cagatgccat taagatgttt gtcggacaga 840 tcccccggtc atggtcggaa aaggagctga aagaactttt tgagccttac ggagccgtct 900 accagatcaa cgtcctccgg gaccggagtc agaaccctcc gcagagtaaa ggtacagagc 960 gcggggcggg ggtcgccagg cgtccaggtg ggcgtcgcgg ggcactgggg ctgtccgagc 1020 ccccagcctg caggaggaag ggcgggtagg caggagggct ggaagcagcc ggtgctggcg 1080 gcccctgtgc tccaggggct gctcccgact cctccccgca cccccgcccg cctgcccgcc 1140 gggacaggtt ggaggcggga gagagggacc gaggcagggc gggagcgcag aggctcggtc 1200 <210> 117 <211> 800 <212> DNA <213> Homo sapiens <400> 117 taacaaataa gccgcccgtg gtccgcgctg tgggtgaccc ttggcgcctt cgaggtctgg 60 agccctaggg taaataagga aacggggcgc ctctagagtt ttaaatgaac tctgttattg 120 gaagcttcag tagggaccct gaaaacaatt aacgtcttaa ttagcatttt aatgtctcca 180 ttattacggc gcgggctcta gctcagccct ttaccttacc ttctcaccgt taacagggga 240 gggggattgt atttttagtt catcttttta tgtttttgag ttgttatcct gtctgtctga 300 ttccagcctc gagggtttga tgatgcggcc cgagcctggc tgtggtcgcc tgtcggggct 360 ggagcgggac cctcagccgg gccgggcctg ggggctaacg ttttcacagt gcgccctgag 420 tttccttggg ttactgctgg gaccgcgcag gaggaagcaa agagtttttc gagctagacc 480 aacaggaaac acattgacgg aaatgttgcc atagcccatg gggtggcttt aactggccgc 540 ccccgcgggc tgggtgtgaa atcagaggag gccgcggctc ccccggccag gattggaggc 600 tcctcgcgca acctaatgcg ggtgtccggg cccgagcgct tcccgcgcag ccaggccttg 660 tcggtgcagc agccccgctc ctccccaaca cgcacacacc cggtgttcgc aagtgcggct 720 caccaaggga gatccaaggg ggcaaaaagt tatgtataaa tccgagagcc actggggaaa 780 gagggtcgtg gtattgtaag 800 <210> 118 <211> 500 <212> DNA <213> Homo sapiens <400> 118 ctaccctgtg ctatcctgag ctgtagtctt ctgaaatgat cgtttggctt cccagccaag 60 gcagggctcc cccaaagttc attcccactc ttgcagtttc acctcgggat gcttccgcag 120 aatttcagcg cctaagcaga caaggtcaaa gtaaaccgct tcaccgctgc ttctggcgca 180 ggggcccaga gcgcgtgcag ctccccagca cagaccaaca gcaggagagg ggtccgggcg 240 ggagccctgg gctgtagata agcaaaacgc acccattttc tctcctattt actccagagg 300 cacctctcct cccccactcc tggcatctct ttatcactgg ctccctctcc ctgtggcata 360 tttttgggta gtagaatgct gaggtcacag ggagcggctc tttatccaag cagtggggac 420 atcagcctgg agccctgagc atgaaccagc aagatgcaga ctctcgctct tgactttggg 480 ctccaggagc tgccccgacc 500 <210> 119 <211> 1100 <212> DNA <213> Homo sapiens <400> 119 cagtgctccg ctccgggaaa ttgcatcgtc acgacaaacg ggaccgtgat aaaacgaccc 60 tttccgtcct tatttgtaga tcactcagac gagattgaac tgcacttgtt tccccttcga 120 ggggagccgc gttttcaggg tagccgaagg cttggggctg agggggggcc ctcaccaagg 180 cgcgggtggg ggccggagcc tcaactcgat gagaagtgac aggcgtttgg gggatctggg 240 ctccggccgg gaccagcgca agcagggact ttgcggggac accgcttctc caacagagca 300 aggcctggcc cacgtttccg gtttctccta acttcctttt attgccttcc tttgcttcgc 360 aagttccatc tacccctcca gctacagagc cccacctcta ggcacaggaa gcttcccgga 420 aaaagaaagg ctgtcccaga aagagaccga gagagacttt ccaaacttcg ggcatagcca 480 cggcaattcc cagtctgcta atgccaaggc gggcgcgtaa ggccgcctaa atctagacct 540 ccctcctcac tcatttcaaa aaataacaac gtgccagcca cctccgcaga taccgccggc 600 tggtgcttgc ccaggagacg ccagggccag agcgccactc ccagcatcga aatggcagag 660 agaaagcgca gctccaaatt ccccttcaga ggttaagcct caatcattgt gtcccttccc 720 tagggactgc tggcgctctc gcccactggc gatgattatg cgcctagaac tcgaccgcga 780 agcaactaat aggaaaacat atggtgtcaa tttggatgct ccgcgcctcg cgcacacccg 840 ggaacgagcg gcacaaagcc ctgccggccg gcccgcgacc ccgcgcccct cggggcctgc 900 cagccgggcc gcagcgacaa acgctcaggg ctgcgcgccc tggctggggc ccgcccgaga 960 gacagcctgc ggctggggag tctgagctcc aaggggagag cccagccgcc gaaggcgagc 1020 ctaccggcca agccctgggg tccggcaggt tctgcacaac tactcccgca aagctcgcca 1080 cctttgtgcc ctttcctcag 1100 <210> 120 <211> 500 <212> DNA <213> Homo sapiens <400> 120 gggccctcgc ggctcaagcg ccagcgctgg agagagagtc tgagggtacc acgggcgtgc 60 tggcctgggt gctcactccc gccctccttc atgagcggct ttcctctggg tgtgtccagg 120 gcatcacaga gctcttctgc ccaaacccgg aggcctacca gggcctgccc accttgcctc 180 cttccacact ctctgtagca gcagccgcag ccatggcggg gatgaagaca gcctccgggg 240 actacatcga ctcgtcatgg gagctgcggg tgtttgtggg agaggaggac ccagaggccg 300 agtcggtcac cctgcgggtc actggggagt cgcacatcgg cggggtgctc ctgaagattg 360 tggagcagat cagtgagtgt ccgctgcccg cttgctgaac tcggcaccat gggcggccgc 420 cacgggtgtc tctgggcact tccgggccat ccctgctgct cagctcccga taatggtgtc 480 acggtgactc aggcattagc 500 <210> 121 <211> 600 <212> DNA <213> Homo sapiens <400> 121 tgtttacgga atcgggatcg aggggccgat aagtagttta cacgccggcc agagcagagg 60 gctggaggtc ggagttgggg gctggaggaa cgggtggcgt ttttaggatt cagtaacagg 120 atcacagctt tttcttgtgg tggaagctat tggaatttgg ggagggtagc acgaggggtc 180 ctgcagctcc gcgtgtgaaa aagcgtttag gtaggcgatg aaagtagttg atctgagcca 240 tggcaggcga gccccgaatt tttgctgctt ccccctgaaa gtgtttcttt aggaggagag 300 gacttgggcc acacaggacc cggtcctaag agagcgattc cgggaagcgg acagatcgaa 360 gagaccttct gggcgaagcg gcagggcagc ctcgcggggc tgggagtgga tctgaggtcc 420 cgacccaggc ggctcggagt gctccaggag ccacctgggt ctgcgggcgc agcgcggcgg 480 ggcgggagcg gtggcccgca ggggccgcgg cctgcgatga aggccggggg gcagcgctag 540 cagcgaggtg ccacagtggg ccgaggagtc tgggctgtgg cccagggtag gaccggctca 600 <210> 122 <211> 150 <212> DNA <213> Homo sapiens <400> 122 acctaaacca agctctccct ccctgccgtc tccttccctg gcctgggtct gaaggagagg 60 aggtgcccag aagttcagag cggcataacc acagagatac tacctaatta acataccaga 120 agcataaaga actcatttgc attggagagt 150 <210> 123 <211> 900 <212> DNA <213> Homo sapiens <400> 123 ataactacgg gggtgggggt ggggaaggaa gagatccaag gaggcagaag gctgcggtca 60 aaatattttg gggtggcaga gtcacgtagg atgtggctgt gggttctggc agcccagaga 120 ttcagctccc gcctcctccc tcagagcgag tccatagcta ccctcacgtc ccccgtggcg 180 gtcctcgcca cgctccggag cgggttaccc atgagggtgc tagacctggg cagcgggaac 240 ctcgaagagg tggagattgc aggctgggac tccagatttc gggcagggat gcggggaagg 300 gaagacgcct cgctggaggc ggaatggagg gcaaggcgaa ggaggatggt gcaggaaacg 360 gcgacaaggc gcccggccag gcccgcgagc taccgagacc cgggttccaa tcctcccccc 420 ttccgcaaac gcccgggttc gaggtacctg gcgggcaagg gccgcagcgg agcgaagcgg 480 gctggccatg gggaggctgc ggggacgcgg ggctgcagag agcggcagtg gcacggagcg 540 cgcggctgga agcgaaagca ggcggtgtgg ccaagccccg gcgcacggcc catagggcgc 600 tgggtaccac gacctggggc cgcgcgccag ggccaggcgc agggtacgac gcaacccctc 660 cagcatccct tggggaggag cctccaaccg tctcgtccca gtctgtctgc agtcgctaaa 720 accgaagcgg ttgtccctgt caccggggtc gcttgcggag gcccgagaat gcgcgccacg 780 aacgagcgcc tttccaagcg cagatatttc gcgagcatcc ttgtttatta aacaacctct 840 aggtgaatgg ccgggaagcg cccctcggtc aaggctaagg aaacctcgga gaaactacat 900 <210> 124 <211> 600 <212> DNA <213> Homo sapiens <400> 124 cagtccagcc gcttgcctca cttcttcccg cttgccttat ctccccgcag acgtggttcc 60 cctgcagccc gaggtgagca gctaccggcg cgggcgcaag aaacgcgtgc cctacactaa 120 ggtgcagctg aaggagctag agaaggaata cgcggctagc aagttcatca ccaaagagaa 180 gcgccggcgc atctccgcca ccacgaacct ctctgagcgc caggtaacca tctggttcca 240 gaaccggcgg gtcaaagaga agaaggtggt cagcaaatcg aaagcgcctc atctccactc 300 cacctgacca cccacccgct gcttgcccca tctatttatg tctccgcttt gtaccataac 360 cgaacccacg gaaagacgct gcgcgggtgc agaagagtat ttaatgttaa ggaaagagaa 420 gaaccgcgcc gcccggaggc agagaggctc catggccgtg ctgctgggcc atccccaact 480 ccctatccca tccccagcct ccacccccat ccagatggga ctcacgtggc ttcaacagct 540 ttggaaatgg gtcccgagtg ggccgtgcga ggaaggctgt cgacctctac tcctccttgc 600 <210> 125 <211> 1500 <212> DNA <213> Homo sapiens <400> 125 caagatcgac tttcttagga agggggagag gagggaactc ttcacgaagg gaggtgggag 60 tccacctcag acctctattg gaaggaaatc gagttgttcc gggggactga ggtctcttgc 120 ataaggcatg ggatccttat tattattatt attattttta aatcccccgc ggaggagctc 180 tgggcaaatg aataccgagg cgccgctcta gctggttagg cttgggatgc gataactcag 240 tgccctcttg cagacttgca tagaaataat tactgggttg tcgtggaggg gacacgagac 300 agagggagtt ctccgtaatg tgccttgcgg agagaaaggt ccaagaatgc aattcgtccc 360 agagtggccc ggcaggggcg gggtgcgagt gggtggtgga gtaggggtgg gagtggagag 420 aggtggtttc tgtagagaat aattattgta ccagggcccg ccgaggcacg aggcactcta 480 ttttgttttg taatcacgac gactattatt tttagtctga tcaatgggca caatttctaa 540 gcagcgcagt ggtggatgct cgcaaacttt tgcgcaccgc tggaaaccca ctaggttgag 600 ttgcaaaacg taccgcgtag acgcccctgg tggcgccgag agaagagcta ggcctgccca 660 gcacagagcc ggagagcgtc gggccttccg gaagggtaag ttctccgcca aggggtcccg 720 agggagctgg acgtctgaat ctggacttgc ccccagcttc ggggttcgat tctgggtttt 780 gcgcgtcccc aacccccagg gctttccgaa gcatggcctg gctccaggcc cggtcctgta 840 aggactggaa cggcagcaaa atgtgcaggg aggcagtcgg ccggcagagc tgcggcggga 900 gccaaggtca ggcccgcggg gagagcgggc agcttccagc gccggccaca agctcccagg 960 ccagctgggc cgcagacccc tttgcttcca gagagcacaa cccgcgtcct ttctctcagc 1020 caggctgcag tggctgcccc gagcttcgct ttcgtttccc aagctgttaa taacgatatg 1080 tccccaaatc cgaggctcgt gtttgctccc agatgccaag aacgcaaccc gaaatccttc 1140 tcccaaaccc taggtcgacg agatgagttc ctacttgacc tctgagccga ggtgggccgg 1200 aaaccgaggc ctaggccccg ccggggctgc aaggaaaagg ggaaactccg agcgtagcgt 1260 cttttccttg tggttccttt ctccggcatc ccggactgcg ggccctgcag ccacctggac 1320 cggcattcaa aggattctgc aagtccagct tcacagactg gctttcccag acgctccgaa 1380 gcccgcacca cgaacagaat aaaggagaga cgagagatcg caactagatt tgagaatcct 1440 cgttcttttc cccaatcgtt cgggcagtaa actccggagc cggctacagc gcgcatcctc 1500 <210> 126 <211> 500 <212> DNA <213> Homo sapiens <400> 126 actgtcctcc tccctcaatt gcctattttt tgcccatagc tctaacttaa ccctgtgatc 60 accccagatc gctacttctg acccccatct cctctcccac accaacctcc agcgcgcgaa 120 gcagagaacg agaggaaagt ttgcggggtt cgaatcgaaa atgtcgacat cttgctaatg 180 gtctgcaaac ttccgccaat tatgactgac ctcccagact cggccccagg aggctcgtat 240 taggcaggga ggccgccgta attctgggat caaaagcggg aaggtgcgaa ctcctctttg 300 tctctgcgtg cccggcgcgc ccccctcccg gtgggtgata aacccactct ggcgccggcc 360 atgcgctggg tgattaattt gcgaacaaac aaaagcggcc tggtggccac tgcattcggg 420 ttaaacattg gccagcgtgt tccgaaggct tgtgctgggc ctggcctcca ggagaaccca 480 cgaggccagc gctccccgga 500 <210> 127 <211> 900 <212> DNA <213> Homo sapiens <400> 127 ctcagggaat cacatgtccg cctggcctgg cctggtacca aatgtttata gacaggacga 60 gggtcgctgg aatcgcctcg ctcctttcag cttggcgcta aggcgcgaat ctcgatcctc 120 ctagtatttc tctggcgtct gtctctatct cagtctctgc ttttgtctct ttctccctcc 180 ctccgcccca gtctttccgt ctctttttcc tcgaatgcac gtggaattcg gaattgaaaa 240 ttgaggtcag aatctccctt tttcttccag ttatccgcgc cgctgcccca cgcctagcgg 300 cttggatctg catagacatc tatctacccg caacaagatc cgagctgcag aagcaaacct 360 aatctgtctc cgcaccatcc cctgctctgt agacccactg ccccatccca cgccacatcc 420 ttgaggttca agtagcgact ccagcggatg attcggagaa tgccctgctt tccaaaggcc 480 ccaacccgtg tttttatttt ctttttcctt tgcccgcttg accaactttg gtttctttca 540 gggcccggag gtgcctgcgc cgcgcttggc tttgctttcc gccgccccag gagacccggg 600 actgtggttt ccgctcgcca catcccagcc tggtgcgcac acaagagcct ggcgagcttc 660 cctcgcgcgc ttacagtcaa ctactttggg cctcggtttc cctgctcctt gtagatcaga 720 gaagggacgg gcgaaatgcc tgcgagggag ggttggcgaa tgggttggtt ggtggcaaga 780 ctgcagttct tgtacatgga cgggggttgg ggggtcaaca ctggaagaac tcctgcctga 840 cgccaagagc cacccgcttt ccagctcgtc ccactccgcg gatgtttacc caccttcatg 900 <210> 128 <211> 500 <212> DNA <213> Homo sapiens <400> 128 tttggggcac ccaacccttc ccaagcctcg gttttcccga tcttgtggga tccttgcggc 60 gcgaatgggg ttggaagcac cttggaagct acagagtacc gggtcgggac aatttccggc 120 actgccccag ttcagtggtt tatagaaaat ttctttctct ctctcaggtc cactaagacc 180 gagagagaga gagaagtcga ctctggcaca cccgggcgag gggctgccgg gattcgggag 240 ctggcgcggt tgattttttc cgagaatcct ccacttgggg tgacgtcggg cagcgcgcgc 300 gggccgtgag gttaatgccc aggcttttct ctaaagcgtc cgggaatgat ccggcgaata 360 aaacgggtgt ctgcaaagtt aatgaattgt acaaggaggc tgagggtggg gacttcgacc 420 cggggagcca gaggcggttc tggtggacgc ttccccgtgc gcctaggggt gcgctgggct 480 ttcccagccg aggtctgcag 500 <210> 129 <211> 2000 <212> DNA <213> Homo sapiens <400> 129 ccagacagtt aaggtaaaac gttgaagtca agaggaagta gtgagtctgt tgccaactgg 60 atagggttgg tcctgtccca tctaaatgta ttagaattaa gtggctttta aaaatgagct 120 ggtcatcttc agcccacggg ctggccaatt tggaacttaa tgggcctttg cgtcctcctt 180 ccctgagcct ccttttattc cagacttctc agtgtgagtc tgtgcgtccc tccgacgatc 240 tcagggagtg gggtgccttc atctgcctgt tccctgttcc tcaggctgac gctcccgctg 300 tcctccccgc ctcccctcac tccttttctc cctcccttcc tccttgtggg gaggctcttg 360 gccagggtcc ctgagcccgg gcgggtgctg gcagaggacg cagaaggggt gaggtcacgt 420 ctcccttgag ccccgagccg ctggcttttc agagcctcgc cacaagccgg cggccagagc 480 cccagaccac acagaccgtg cgctcctccg ccctcccggc gccgccggcc tcgcccatgt 540 ctcagtacgc ccctagcccg gacttcaaga gggctttgga cagcagtccc gaggccaaca 600 ctgaagatga caagaccgag gaggacgtgc ccatgcccaa gaactacctg tggctcacca 660 tcgtctcgtg tttttgccct gcgtacccca tcaacatcgt ggctttggtc ttttccatca 720 tggtgagtga atcacggcca gaggcagcct gggaggagag acccgggcgg ctttgagccc 780 ctgcagggga gtccgcgcgc tctctgcggc tcccttcctc acggcccggc ccgcgctagg 840 tgttctttgt cctcgcacct cctcctcacc tttctcgggc tctcagagct ctccccgcaa 900 tcatcagcac ctcctctgca ctcctcgtgg tactcagagc cctgatcaag cttcccccag 960 gctagctttc ctcttctttc cagctcccag ggtgcgtttc ctctccaacc cggggaagtt 1020 cttccgtgga ctttgctgac tcctctgacc ttcctaggca cttgcccggg gcttctcaac 1080 cctcttttct agagccccag tgcgcgccac cctagcgagc gcagtaagct cataccccga 1140 gcatgcaggc tctacgttcc tttccctgcc gctccggggg ctcctgctct ccagcgccca 1200 ggactgtctc tatctcagcc tgtgctccct tctctctttg ctgcgcccaa gggcaccgct 1260 tccgccactc tccggggggt ccccaggcga ttcctgatgc cccctccttg atcccgtttc 1320 cgcgctttgg cacggcacgc tctgtccagg caacagtttc ctctcgcttc ttcctacacc 1380 caacttcctc tccttgcctc cctccggcgc ccccttttta acgcgcccga ggctggctca 1440 cacccactac ctctttaggc ctttcttagg ctccccgtgt gcccccctca ccagcaaagt 1500 gggtgcgcct ctcttactct ttctacccag cgcgtcgtag ttcctccccg tttgctgcgc 1560 actggcccta acctctcttc tcttggtgtc ccccagagct cccaggcgcc cctccaccgc 1620 tctgtcctgc gcccggggct ctcccgggaa tgaactaggg gattccacgc aacgtgcggc 1680 tccgcccgcc ctctgcgctc agacctcccg agctgcccgc ctctctagga gtggccgctg 1740 gggcctctag tccgcccttc cggagctcag ctccctagcc ctcttcaacc ctggtaggaa 1800 cacccgagcg aaccccacca ggagggcgac gagcgcctgc taggccctcg ccttattgac 1860 tgcagcagct ggcccggggg tggcggcggg gtgaggttcg taccggcact gtcccgggac 1920 aacccttgca gttgcgctcc ctcccccacc ggctcacctc gcctgcagct gggccacgga 1980 actccccggc cacagacgca 2000 <210> 130 <211> 600 <212> DNA <213> Homo sapiens <400> 130 ctctctgggc cttaggaaaa tggaaatgac acctgtacct gcccttccag gactgacagg 60 aggggctgct ccatgaaacc tcactgctgc ggtcataatg tcattatctt ttgccttaaa 120 gggatttctt ctgcaccagc acctaaagtg gcagcccctt acccttggcc atcagctgga 180 ccctggtgct ctcctggagc ccaaaacctc tgttttgtgt tgcatcctgc tgaccagcca 240 cagtccacac ccatctgagt gtctgagcag aacagcccag aggccacacc aggatggctt 300 tccaccggtc accttccccc acccactcat aaaccctgcg tctctggggg agagggtggc 360 gaggtcccct ccccacatag atggaaacac tgaggcctga ttcatggtgc cccctgtgaa 420 gcgcctcatg gccagcaccg gggggcagca ggccagggcg gggacacata cccggttctc 480 gtcgtagatg atctgcacca ggctgcggtg cttcgactcg atgggcggcg gtgacacggg 540 cttctcaggc tcgggcggct tggcagcctc ctcctccagc tgttgctgtg gggagaggca 600 <210> 131 <211> 400 <212> DNA <213> Homo sapiens <400> 131 cttgaaaact cccagccccc tttgtccaga tggggatgga ggtggccagg ctgccccgtt 60 gattgtgtgc cgaggagccc tccccgggaa ggctgtgatt tatacgcgca ggcttgtcac 120 ggggtgaaag gaagggccac tttttcattt tgatccaatg ttaggtttga aagccaccca 180 ctgctgtaaa ctcagctgga tccgcgggcc gtgattaaac acattgcccg ctttgttgcc 240 gagatggtgt ttcggaaggc gctgtgaatg cacttccctt tgcggggctc acacagacaa 300 gatgtgtgtt gcaaggatga ggcgcctgct cggcctccag cccagggccg ggaagggaga 360 aggtgctgtg cgtcgctgcc tgtgtcgccc gcggctctcc 400 <210> 132 <211> 1200 <212> DNA <213> Homo sapiens <400> 132 cgcgtcaggg ccgagctctt cactggcctg ctccgcgctc ttcaatgcca gcgccaggcg 60 ctcaccctgc agagcgtccc gcctctcaaa gaggggtgtg acccgcgagt ttagatagga 120 ggttcctgcc gtggggaaca ccccgccgcc ctcggagctt tttctgtggc gcagcttctc 180 cgcccgagcc gcgcgcggag ctgccggggg ctccttagca cccgggcgcc ggggccctcg 240 cccttccgca gccttcactc cagccctctg ctcccgcacg ccatgaagtc gccgttctac 300 cgctgccaga acaccacctc tgtggaaaaa ggcaactcgg cggtgatggg cggggtgctc 360 ttcagcaccg gcctcctggg caacctgctg gccctggggc tgctggcgcg ctcggggctg 420 gggtggtgct cgcggcgtcc actgcgcccg ctgccctcgg tcttctacat gctggtgtgt 480 ggcctgacgg tcaccgactt gctgggcaag tgcctcctaa gcccggtggt gctggctgcc 540 tacgctcaga accggagtct gcgggtgctt gcgcccgcat tggacaactc gttgtgccaa 600 gccttcgcct tcttcatgtc cttctttggg ctctcctcga cactgcaact cctggccatg 660 gcactggagt gctggctctc cctagggcac cctttcttct accgacggca catcaccctg 720 cgcctgggcg cactggtggc cccggtggtg agcgccttct ccctggcttt ctgcgcgcta 780 cctttcatgg gcttcgggaa gttcgtgcag tactgccccg gcacctggtg ctttatccag 840 atggtccacg aggagggctc gctgtcggtg ctggggtact ctgtgctcta ctccagcctc 900 atggcgctgc tggtcctcgc caccgtgctg tgcaacctcg gcgccatgcg caacctctat 960 gcgatgcacc ggcggctgca gcggcacccg cgctcctgca ccagggactg tgccgagccg 1020 cgcgcggacg ggagggaagc gtcccctcag cccctggagg agctggatca cctcctgctg 1080 ctggcgctga tgaccgtgct cttcactatg tgttctctgc ccgtaattgt gagtccccgg 1140 gccccgaggc agcagggcac tgagactgtc cggccgcgga tgcggggcgg gaagggtgga 1200 <210> 133 <211> 2000 <212> DNA <213> Homo sapiens <400> 133 cttccgccgc ggtatctgcg tgcccttttc tgggcgagcc ctgggagatc cagggagaac 60 tgggcgctcc agatggtgta tgtctgtacc ttcacagcaa ggcttccctt ggatttgagg 120 cttcctattt tgtctgggat cggggtttct ccttgtccca gtggcagccc cgcgttgcgg 180 gttccgggcg ctgcgcggag cccaaggctg catggcagtg tgcagcgccc gccagtcggg 240 ctggtgggtt gtgcactccg tcggcagctg cagaaaggtg ggagtgcagg tcttgccttt 300 cctcaccggg cggttggctt ccagcaccga ggctgaccta tcgtggcaag tttgcggccc 360 ccgcagatcc ccagtggaga aagagggctc ttccgatgcg atcgagtgtg cgcctccccg 420 caaagcaatg cagaccctaa atcactcaag gcctggagct ccagtctcaa aggtggcaga 480 aaaggccaga cctaactcga gcacctactg ccttctgctt gccccgcaga gccttcaggg 540 actgactggg acgcccctgg tggcgggcag tcccatccgc catgagaacg ccgtgcaggg 600 cagcgcagtg gaggtgcaga cgtaccagcc gccgtggaag gcgctcagcg agtttgccct 660 ccagagcgac ctggaccaac ccgccttcca acagctggtg aggccctgcc ctacccgccc 720 cgacctcggg actctgcggg ttggggattt agccacttag cctggcagag aggggagggg 780 gtggccttgg gctgaggggc tgggtacagc cctaggcggt gggggagggg gaacagtggc 840 gggctctgaa acctcacctc ggcccattac gcgccctaaa ccaggtctcc ctggattaaa 900 gtgctcacaa gagaggtcgc aggattaacc aacccgctcc cccgccctaa tccccccctc 960 gtgcgcctgg ggacctggcc tccttctccg cagggcttgc tctcagctgg cggccggtcc 1020 ccaagggaca ctttccgact cggagcacgc ggccctggag caccagctcg cgtgcctctt 1080 cacctgcctc ttcccggtgt ttccgccgcc ccaggtctcc ttctccgagt ccggctccct 1140 aggcaactcc tccggcagcg acgtgacctc cctgtcctcg cagctcccgg acacccccaa 1200 cagtatggtg ccgagtcccg tggagacgtg agggggaccc ctccctgcca gcccgcggac 1260 ctcgcatgct ccctgcatga gactcaccca tgctcaggcc attccagttc cgaaagctct 1320 ctcgccttcg taattattct attgttattt atgagagagt accgagagac acggtctgga 1380 cagcccaagg cgccaggatg caacctgctt tcaccagact gcagacccct gctccgagga 1440 ctcttagttt ttcaaaacca gaatctggga cttaccaggg ttagctctgc cctctcctct 1500 cctctctacg tggccgccgc tctgtctctc cacgccccac ctgtgtcccc atctcggccg 1560 gcccggagct cgcccacgcg gacccccgcc ctgccccagc tcagcgctcc ctggcggctt 1620 cgcccgggct cctagcgggg aaaaggaagg ggataactca gaggaacaga cactcaaact 1680 cccaaagcgc atgattgctg ggaaacagta gaaaccagac ttgccttgaa agtgtttaag 1740 ttattcgacg gaggacagag tatgtgagcc tttgccgaac aaacaaacgt aagttattgt 1800 tatttattgt gagaacagcc agttcatagt gggacttgta ttttgatctt aataaaaaat 1860 aataacccgg ggcgacgcca ctcctctgtg ctgttggcgc ggcgggaggg ccggcggagg 1920 ccagttcagg ggtcaggctg gcgtcggctg ccggggctcc gcgtgctgcg ggcggggcgg 1980 gcccggtggg gattgggcgc 2000 <210> 134 <211> 1000 <212> DNA <213> Homo sapiens <400> 134 agtttgggga gccttttctc catttgagaa aaaacaaact tacagcgagg ggtgaggggt 60 tagggtttgg gattggggaa aatgtgggtg gggagccccc ccaaggaagt gaggaggggg 120 ctgcaaggat tacacctggg catacgtttc cctagaaatc acattcattg tatttttata 180 atttattcta aatctttcat gcgaagaaag tcagtagtga gtgttagtac tggtggccct 240 cctgatcaca cttgcatctc ttgagtgtgc cttaaaggtc ttgggaatgg aaaatataaa 300 aactgcttcg tgatgcgtca tctttatccc ccactccccc acccattcca atatattttc 360 tacttccagc ctaaattcgg ggccccctac cgaggccggc catgatcttg agggcggcat 420 aggggaggcc gcgctctgtc caccccagcc tggtgatgcc gttcgcttct tgtgcccggt 480 attgtgggct acatgccttt ccggcgtacg gagctgagcg tccaggccag tgcccctcaa 540 cctctcagta atgtttaccc gaggccgtcg tgcaatgaga ctattcgcat ggcattgtca 600 acgcggcggc gcgcgcgtct cggccctccg cggcttgcca gactgtcctg caaaccacct 660 cacccgtctc tttggcgcag gagactcagg ctgtaaccgg agaaaacact tcaccctgga 720 accctaactc aggtcctggc aaaagatgcg agaggaagac ttgctctctt aataaatctc 780 ggccgcccgc acatctggcc cctagacctg ctcggtagag gactggctgg tggatgcgcg 840 gtccaggccg tgggcactcg acccacctct attttccttc ccgaggcgcc cctggattac 900 cactttcggt ttgcgcttac atccgggatg tcgaatttcc cagggaatca taattatttt 960 atctataatt tattctaacc ccaaggttcc aagaaaatct 1000 <210> 135 <211> 1100 <212> DNA <213> Homo sapiens <400> 135 acattccttc taaaatgtgg gctttctgtg tacatgggcg cgcattccca ggactcggtt 60 ccctgggtgg aattcaccca ggaatacaat cgattttctg aacctgcgta aggccacagg 120 cagctctgaa aatgaaagcg tttgctaagt gggggagatc tcaccgatcg aacgtttaaa 180 aatggctttg tcttcattca gctctcccga tttattctgt gttttacaaa tagaagctca 240 gagcttctgt cgcccagtcc ttgcatgact catggcggtg gccacacggg tttcagggat 300 aacgggatgt ttagaaaatc gctgcatatc ggagtttcct agcacgttcc atttatactg 360 aacgcaggcg gccgctgaaa atccagcctc gactcttgct aatgactggg taggaccctc 420 ggggtcctgc gacggtgctg gagggtgttc ccggctccga tgtggggagg cctgcgcggg 480 gactaggttc tcgagaggcg agcgggcgcg ccagagaacc cgagactgct gcggggccgg 540 atgcgggatc cctgggctgc ggttctacgc agaaacgcca atggccatgc ctccccagct 600 cctcccagcc ccagtcacta ggccggcgcc tggcccggag atcctcccag agccctggcg 660 gtgccatcat gccggagaag acaagctcgg ccccgctgga attcgctcca aacacagatg 720 ctcatttttg gaatattcta gaaaaataac aagatcttgt ttgtcgttat gattcacggg 780 aggtaactga tgggagggcc atttacatga gggcagacac tgtggggcga aggtgacttc 840 tggacgtagg ctttaaagta ggaacggctc caaattccca atatctccgg ccttaccggt 900 tgcaaatcgg acccctgcgg gaaaaccaga cacttctgtt tcgtggcttt cgggctgcct 960 ccagcccacg caggctcgtt tagtccccgt ggagtcagcc ccgagccttc ctagtcctgg 1020 aacaagggct ccaggtcgcg gccgcgggaa gccgccaaga gggcggggag tagggattcc 1080 ctccagctcc gcagggcatc 1100 <210> 136 <211> 1500 <212> DNA <213> Homo sapiens <400> 136 tcctcctcgg cctcagatgt cgtcccacct gcccacgagc agggaacctg gaacccactc 60 tcccggcagt ccccagcggg ttccgccacc cggcggccgc ccctgacacc gagtgggtgg 120 gaggaagagg cagctggcgg ggatgggcca ttgagacctc ttgaaaaata ttaaaagaca 180 ggatgggtag agatttctcc gggagaaagt tcgagggtgc atcgggtcgc ggctgggagg 240 agtacccgaa atgccagcag gagaaatgca acctgtttag gccacacctt caatccccga 300 ggctgtctgg agagactgcg tgcgggggac ttgccggcgt tcccacaccg cgcctgcaat 360 ccactcccgc ggctgcctgg cctctgccac tcgcggcttg aagccagtgg ctctcaagcc 420 ctcggccccg cggcggcccg cgcagccttc acccggcgcc ggcaccacga agcctggccg 480 cagtggactc cccgcagctc gctgcgccct ggcgtctccc gtcgaggagg gagggacgga 540 ggcctgagcc gggagctccc tggcggtggt cgggccgccc cccttgaggc ctgctccccc 600 ctctcggcct cgccaaatcc ctgaaagccc agtccccctt cgtcaccccg ggggcttcta 660 atcactcggt atcgatttcc ctaactcttt tcatcctgtt gaagacacat cttaaaacac 720 tccagcccgg agtgtgctct gggctttatc cacactaata aaatgattta cccttctctc 780 cgcgctctcc tcacagagga aaatcgttcg agccccggct atttgtgtgt gatcagtaaa 840 tatttagtgc gctgacatcc ttagctgggc ttcggatcga ttcggggccc accgggaggt 900 gcgcacggtc cgggcggggc cgcgccgagc tcgccgaggg ggctcctccc gccctcgccg 960 ccggccgctg atttacggcc cctgcaacca gctaaggggg gcgaaagcgc gcctggaaaa 1020 ttggcttttc aaccttttac ttttgacatt cagccacttc cccaggctct aattctcgcc 1080 cgcactcctc cctcccgccc tactaagggt tgccctgtgc gccctgcgag cccttccagc 1140 agcaacgcgc ggcgctcgcg ccccctcggc ccggggacca cctatcacag ccctgagccg 1200 cgacgcgggg aggccccggc ccctgctatg ggggtcgcct ccttcgagga gagatgctct 1260 ccgcccgccc acacctctga gggaggagag ggggtggaga agcccagagc tgcatctgct 1320 ggatgacgag ccgctctccc tgctaccctt tctccgaccc gtcggccttt ctcctactct 1380 ggagactgat cctcgacgtc catcgggccg gatggcgtcg ggtggaagcg ttactttcct 1440 cgcagaaaaa ctcctcctct ttcctaagat cagaaaaagc gcttagcttg gaattgttag 1500 <210> 137 <211> 600 <212> DNA <213> Homo sapiens <400> 137 cctaggcatt ctcagcccgt tttgctggag ggggcatttg aggcctggcc agcttagcca 60 gcctacaagg agtgttactg gggtgaaaac agccagcggg gaccagtctg cttgtggccc 120 gccaggtgcc tgggatgggg aagcagcaaa tgcccacctt cctgcccaac cccctcctcc 180 ctcttcatgg ggggaactgg gggtggcagc ggctgccggg tgcgagcggg ctcaggcctg 240 tggccctgcc tgacgttggt ccccatcaag ccatgtgacg agaccaggcc acaagaaaga 300 ggtttcaaca agcgttatcg tttcctggaa ctccaactcg gcgacttccc cgaagaccgg 360 ctgtgcctgg cgggcgggct gcgcacagcg gggacaaggc tgcccccttc ctcctccgct 420 gcctccgcgg ccgcgtctat ctcagtctga ctacctggaa gcagcactcc accctccagc 480 ccagcggccc tcggctcagc tgccaggtca ccggcaaccc cgggagcggt ggggcagggg 540 ctgctccgcc agcctctgtg atgttcaggc cgggctgcac cagcccggga cccctaggtg 600 <210> 138 <211> 700 <212> DNA <213> Homo sapiens <400> 138 gcactggttc ccctttacct gagccaacaa cctaccagga agtttccatc aagatgtcat 60 cagtgcccca ggaaacccct catgcaacca gtcatcctgc tgttcccata acagcaaact 120 ctctaggatc ccacaccgtg acaggtggaa ccataacaac gaactctcca gaaacctcca 180 gtaggaccag tggagcccct gttaccacgg cagctagctc tctggagacc tccagaggca 240 cctctggacc ccctcttacc atggcaactg tctctctgga gacttccaaa ggcacctctg 300 gaccccctgt taccatggca actgactctc tggagacctc cactgggacc actggacccc 360 ctgttaccat gacaactggc tctctggagc cctccagcgg ggccagtgga ccccaggtct 420 ctagcgtaaa actatctaca atgatgtctc caacgacctc caccaacgca agcactgtgc 480 ccttccggaa cccagatgag aactcacgag gcatgctgcc agtggctgtg cttgtggccc 540 tgctggcggt catagtcctc gtggctctgc tcctgctgtg gcgccggcgg cagaagcggc 600 ggactggggc cctcgtgctg agcagaggcg gcaagcgtaa cggggtggtg gacgcctggg 660 ctgggccagc ccaggtccct gaggaggggg ccgtgacagt 700 <210> 139 <211> 300 <212> DNA <213> Homo sapiens <400> 139 tgtccgacag gcacacagag cgccgccagg cacggccctc attcttcacc ccgagctccc 60 gcaaggtcgg cgaggaggct ggagcagcgg gtaggaagcg ggccgaggct cccccgacgc 120 tgggccgcaa ctgtcatcgc agatccctga aaaacgagct ctgtaatcgt tgccgtcagc 180 gggtgtacaa ttgcagcctt atgtttcctg ccgctgttta ccttcctgag cggcgcccag 240 agatgcacac acgctgccct gaagcgggac gtgacctctg ggcacctgtg aggtcctggg 300 <210> 140 <211> 500 <212> DNA <213> Homo sapiens <400> 140 gtcggctcct gcgctcccaa cggggtggcc gtttccttcc tcgcaccctc ttctctcccg 60 gtgcctgcgg tcccaccttc cagatacccc tcggagagtc cagctgagct ctcgccagag 120 ctttcccctt ccaacccgct cgacttgccc agatcccaag ctgggcttct ctctccatcg 180 ccccagaaag tgggtcttgg agaccgaggc aagaatttgg gcctccgctt ctgttccaga 240 ccccggaccc cttgccaaaa tgcggcagat gtgcagattg ggccgcgctt ggttcctggc 300 tgggtttatg gagcctgcgg ctgaggcagg ctccgcagac cccgagccag agtgggattt 360 aacggcggcc ggtgcgctgt gcttggtcaa ccccggtaac cgtcacgctg ctagtgatat 420 gaaaaaaacc tgccagcgtt ctgcttttct gccccgctgc agtctttagc acccgccagg 480 attctgtccg agtgtttgga 500 <210> 141 <211> 1000 <212> DNA <213> Homo sapiens <400> 141 tttagtgtgt gcataaaaca tcccagctaa tctcaaatag acttttcctg agcagaggct 60 gaaatttgca agtaatgcaa agaagactcc gggagagcgt cgccgatggt ggagcgggag 120 acgggcgtgg ggagccccac tgcagtgctg ggatcgaagt ggtgctgacc ccaagacctc 180 tcccctcctc ctcccccggg agcttctcca gggttatttg ggaaatgagg gggaactcca 240 atccctgaga aagcgctcag gggcttgctg aggtgagcgc aaatggaagc acaaggccgg 300 gctggccgtg ggctcagtaa ccagtcggct gcccggcttg cgccagcact aaatgctcga 360 tcagaaagag aaaaagaggc gcaataattc caaatttcag gaaaagtcaa atcggagagg 420 ggggacgcag gtctcttcag actgcccatt ctccgggcct cgctgaatgc gggggctcta 480 tccacagcgc gcggggccga gctcaggcag gctggggcga agatctgatt ctttccttcc 540 cgccgccaaa ccgaattaat cagtttcttc aacctgagtt actaagaaag aaaggtcctt 600 ccaaataaaa ctgaaaatca ctgcgaatga caatactata ctacaagttc gttttggggc 660 cggtgggtgg gatggaggag aaagggcacg gataatcccg gagggccgcg gagtgaggag 720 gactatggtc gcggtggaat ctctgttccg ctggcacatc cgcgcaggtg cggctctgag 780 tgctggctcg gggttacaga cctcggcatc cggctgcagg ggcagacaga gacctcctct 840 gctagggcgt gcggtaggca tcgtatggag cccagagact gccgagagca ctgcgcactc 900 accaagtgtt aggggtgccc gtgatagacc gccagggaag gggctggttc ggagggaatt 960 cccgctaccg ggaaggtcgg aactcggggt gatcaaacaa 1000 <210> 142 <211> 500 <212> DNA <213> Homo sapiens <400> 142 catggtgctt caggaaggga ggggacgaga gccctgggct tgtggtgtcc acgtggacag 60 ctaatgagga gccttgccga tgaggagcat gcgttcccga cggggcggcc gaatgcggaa 120 ggagccgcca ttctctccgc cctgaccgcg ggattctctg cagcagatga gaaacggcgc 180 tgactcagca gggtccctcc caggccccga gcggtcatct ggtgaccccc gcgcttcccc 240 cacggcccag ccggagaagg gcaaagggaa gtcccggctc caaggcgcac ccagagatgc 300 ggtgcatgtg gcaggatggc ccagccccgt cggcagcccc agcttcctgc ccctggtttc 360 cttcctccca cgggctacag gcctctgatg agctttggaa agcaggaaac acacaggcta 420 gtaactatga atgggtccaa aaaacactcc ttattacttt aaactactta ggaagaagca 480 cagcgttgcc aaacgccaga 500 <210> 143 <211> 1200 <212> DNA <213> Homo sapiens <400> 143 gcgcgggggg ccggaggatg gcggcctggg ggccctgcgg gggctgtcgg tggccgccag 60 ctgcctggtg gtgctggaga acttgctggt gctggcggcc atcaccagcc acatgcggtc 120 gcgacgctgg gtctactatt gcctggtgaa catcacgctg agtgacctgc tcacgggcgc 180 ggcctacctg gccaacgtgc tgctgtcggg ggcccgcacc ttccgtctgg cgcccgccca 240 gtggttccta cgggagggcc tgctcttcac cgccctggcc gcctccacct tcagcctgct 300 cttcactgca ggggagcgct ttgccaccat ggtgcggccg gtggccgaga gcggggccac 360 caagaccagc cgcgtctacg gcttcatcgg cctctgctgg ctgctggccg cgctgctggg 420 gatgctgcct ttgctgggct ggaactgcct gtgcgccttt gaccgctgct ccagccttct 480 gcccctctac tccaagcgct acatcctctt ctgcctggtg atcttcgccg gcgtcctggc 540 caccatcatg ggcctctatg gggccatctt ccgcctggtg caggccagcg ggcagaaggc 600 cccacgccca gcggcccgcc gcaaggcccg ccgcctgctg aagacggtgc tgatgatcct 660 gctggccttc ctggtgtgct ggggcccact cttcgggctg ctgctggccg acgtctttgg 720 ctccaacctc tgggcccagg agtacctgcg gggcatggac tggatcctgg ccctggccgt 780 cctcaactcg gcggtcaacc ccatcatcta ctccttccgc agcagggagg tgtgcagagc 840 cgtgctcagc ttcctctgct gcgggtgtct ccggctgggc atgcgagggc ccggggactg 900 cctggcccgg gccgtcgagg ctcactccgg agcttccacc accgacagct ctctgaggcc 960 aagggacagc tttcgcggct cccgctcgct cagctttcgg atgcgggagc ccctgtccag 1020 catctccagc gtgcggagca tctgaagttg cagtcttgcg tgtggatggt gcagccaccg 1080 ggtgcgtgcc aggcaggccc tcctggggta caggaagctg tgtgcacgca gcctcgcctg 1140 tatggggagc agggaacggg acaggccccc atggtcttcc cggtggcctc tcggggcttc 1200 <210> 144 <211> 600 <212> DNA <213> Homo sapiens <400> 144 gggcgggttg ccacactgtc ccctttctgc atgggaggaa gggggctcga gaactgagtc 60 agccacacaa aacgaggatg gacagaactc ctgagtagcg agggtgcctg ccgggcgcga 120 ggaggagggg gaagacgagg aagacgagga ggaggaatag ggagcaccac atgacagagg 180 ggctgcctca gaccacaaag cgcttcctca tcctttcctc gccctttgat gccgccggca 240 acgtgactct gcgagcagcg gggcagacgc caggtctccc tcgcaggcgg gaaaggggct 300 ccaaggcggg tgctgccttg ctcgggtcac atggctacgt gggggccttg ctcaaattca 360 cttcctgcct tcattacaaa actgtcaaag gggatcgcac gtttgcaggg tgtcacccaa 420 gcattctggt tttgcaaacg acgctgtgcg gcaggcggtc tgatacctga tgagctcggt 480 gtggcggggt cggcagcatt tcctccgggg ttttgagctc tggccacttc tccttttgtt 540 ccacccaatc tcacccactt ctgggcttcg aggccagagt gtcttaacaa gggggcacgt 600 <210> 145 <211> 500 <212> DNA <213> Homo sapiens <400> 145 gagcgagact ttgtctcaaa aaaaaaaaaa accaaataaa ttgaaagctg agaaattcag 60 agcacaagaa gacaagcgcg ccccctcttt tagctgtcaa catggcggag ccgtccctgg 120 tgacgcagcc tccaaaggcc tccctgtgcc ctcctgagac cgcaagaggg aaagtggcag 180 cgacagtgat cgtggtgtct ttgtggcggt tgtgttgacc tcactgaccc ccgaagtgcc 240 gctctagggt ctgtcctcag cggtgacccg gccgggtcga agggcagagt tccgctgtca 300 ctagccctcc acccgtcctg tgtgctggga tgccctcgcg gcgccgtcca cgccaccgcc 360 gccccctctt gtgggttctg tctcctccgt gtctaggatc ctcctgcatc cgtttttcct 420 tcctcccttc tctccctccg tctgtcttgc ccgcacctga ggttgtcgca gaggcgctga 480 gacgggccag caggagctgt 500 <210> 146 <211> 600 <212> DNA <213> Homo sapiens <400> 146 tgctgtcccg gtcctgtcgc agtcctcaaa gatgctagag tgacagtcct ctaggggtag 60 agatggtcgt cctcccagga gaaggtggcc cggagacttg gaggtgggat caatcctgcc 120 agtcctggat caggaggcct ctgtcgggcg ccgcccccct tcctcctcca tcagcaacag 180 gcggcgccgg ccagcctcat agtcagcctc atccacactg accagcaggc gaacagcctc 240 ccggcccaca gcctctcgca gggcctcagt caggaacacg ccccgcaggg cctgcagcag 300 ggcgccactc aggtagtcgc cccagaaggc gtccagatag gagagctctg agaacttgat 360 gtcacaaacc acagagccca ggtcccttga gcgcagcact gcggtggcct gcccaaacac 420 gtccagctgc cgcgccagcg cctggggccg ccgggatgcc acgccctgct ccaaggctgg 480 cccatgctcg cagtactctg ctcgaacccg gagccggatg tctgcagggg aaggagggat 540 ttgtcaggga gggggccaac actagacaca cttatgggga acgccaccct tcctccctcc 600 <210> 147 <211> 500 <212> DNA <213> Homo sapiens <400> 147 tgatgcccgg cccccagggg ggcagaggcg ccgccaccat gagcctgggc aagctctcgc 60 ctgtgggctg ggtgtccagt tcacagggaa agaggcggct gactgcagac atgatcagcc 120 acccactcgg ggacttccgc cacaccatgc atgtgggccg tggcggggat gtcttcgggg 180 acacgtcctt cctcagcaac cacggtggca gctccgggag cacccatcgc tcaccccgca 240 gcttcctggc caagaagctg cagctggtgc ggagggtggg ggcgcccccc cggaggatgg 300 catctccccc tgcaccctcc ccggctccac cggccatctc ccccatcatc aagaacgcca 360 tctccctgcc ccagctcaac caggccgcct acgacagcct cgtggttggc aagctcagct 420 tcgacagcag ccccaccagc tccacggacg gccactccag ctacggtgag ggcctgggcc 480 atcttggccc acttttcaga 500 <210> 148 <211> 110 <212> DNA <213> Homo sapiens <400> 148 tttgggccac gaggcaagtt caaagcggga gacttttgtt ttataaaatg atggtgagca 60 gctccggttt tatgtcaaac atcagggttt cgtgcaggat ataaacattt 110 <210> 149 <211> 800 <212> DNA <213> Homo sapiens <400> 149 tgcctgagcg cagagcggct gctgctgctg tgatccagga ccagggcgca ccggctcagc 60 ctctcacttg tcagaggccg gggaagagaa gcaaagcgca acggtgtggt ccaagccggg 120 gcttctgctt cgcctctagg acatacacgg gaccccctaa cttcagtccc ccaaacgcgc 180 accctcgaag tcttgaactc cagccccgca catccacgcg cggcacaggc gcggcaggcg 240 gcaggtcccg gccgaaggcg atgcgcgcag ggggtcgggc agctgggctc gggcggcggg 300 agtagggccc ggcagggagg cagggaggct gcagagtcag agtcgcgggc tgcgccctgg 360 gcagaggccg ccctcgctcc acgcaacacc tgctgctgcc accgcgccgc gatgagccgc 420 gtggtctcgc tgctgctggg cgccgcgctg ctctgcggcc acggagcctt ctgccgccgc 480 gtggtcagcg gtgagtcagg ggccgtctcc ccgaagaacg agcggggaga ggggaccacg 540 gggcgcggcg ggcagcctgt tctcgggcgg aggctctccg gggcgttgga aacctgcatg 600 gtgtaaggac ccgggaggag gcggggagaa attgattgtg ctgttctcct ccctctcttc 660 tctaacacac acgcagaaaa gtttaaattt ttgtgaagcg cttgcttacg tagctgcgga 720 gcgagcctct gcttcattac gagcggcata gcctttttca ggagtgattt ccactttctt 780 tgtgagagag ttgaccacac 800 <210> 150 <211> 600 <212> DNA <213> Homo sapiens <400> 150 ttcaatttac actcgcacac gcgggtacgt gggtgttcgg ggtagggcac tgatctgggg 60 aaggtctccc ccccgcgacc caactcatct ttgcacattt gcagtcctcc ctcggtgcac 120 tcctggcggg gatctggcca gtgcagcgca ctgggaccga gggcagagcc cgcggagtga 180 ggccaggaga gacttcaggc ctctaaggac acagctgagg ctaaggctga gttgaacgca 240 gcccctcccg cggctcgtcc cctctccagt gtctctcccg taaggtgccg ctcccaacag 300 caatgggtcg agatgtagag gaaacactct gtacgttatt tttccgccca ccctttagcg 360 cctgaggaga cagacagtgt agactttagg gtacaattgc ttcccctctg tcgcggcggg 420 gtggggagcg tgggaagggg acagccgcgc aaggggccag cctgctccag gtttgagcga 480 gagagggaga aggaggtcca cggagagaca agaatctccc tcctcccacg cccaaaagga 540 ataagctgcg gggcacaccg cccgcctcca gatcccccat tcacgttgag ccggggcgcg 600 <210> 151 <211> 1400 <212> DNA <213> Homo sapiens <400> 151 gcctgaagac catttcttcc tctcttaggg acctgctggt ctccagctga ttcggtccag 60 gaggaaaaac ctcccacttg ctcctctcgg gctccctgca aggagagagt agagacactc 120 ctgccaccca gttgcaagaa gtcgccactt ccccctccag ccgactgaaa gttcgggcga 180 cgtctgggcc gtcatttgaa ggcgtttcct tttctttaag aacaaaggtt ggagcccaag 240 ccttgcggcg cggtgcagga aagtacacgg cgtgtgttga gagaaaaaaa atacacacac 300 gcaatgaccc acgagaaagg gaaaggggaa aacaccaact acccgggcgc tgggcttttt 360 cgacttttcc tttaaaaaga aaaaagtttt tcaagctgta ggttccaaga acaggcagga 420 ggggggagaa gggggggggg gttgcagaaa aggcgcctgg tcggttatga gtcacaagtg 480 agttataaaa gggtcgcacg ttcgcaggcg cgggcttcct gtgcgcggcc gagcccgggc 540 ccagcgccgc ctgcagcctc gggaagggag cggatagcgg agccccgagc cgcccgcaga 600 gcaagcgcgg ggaaccaagg agacgctcct ggcactgcag gtacgccgac ttcagtctcg 660 cgctcccgcc cgcctttcct ctcttgaacg tggcagggac gccgggggac ttcggtgcga 720 gggtcaccgc cgggttaact ggcgaggcaa ggcgggggca gcgcgcacgt ggccgtggag 780 cccggcctgg tcccgcgcgc gcctgcgggt gccccctggg gactcagtgg tgtcgcctcg 840 cccgggacca gagattgcgc tggatggatt cccgcgggca gaggcagggg gaaggagggg 900 tgttcgaaac ctaatacttg agcttctttg caaagtttcc ttggatggtt ggggacgtac 960 ctgtataatg gccctggacc agcttccctg ttggagtggc cagagaagtg tgtaaaacac 1020 actagagggg cagggtggaa aaagagactg ccttcaaaac ttgtatcttt tcgatttcat 1080 tttgaaaaat aactacaaat ctattttaat tttacaaagt tagactcata gcattttaga 1140 tatcaatgtc ttcatttaac agaagtgaag atggagcaaa cgctcaatca gcgtctgtat 1200 ttattcgctc ctgttgtgcc agggtgcgtt tttgccgagc ggttgccttt ctttactcac 1260 aaaaccccct tgatgtctgt cctccacgtt ttacgaggga gagccggatc ttttgaagtt 1320 tgtatcatct aaagcaggta tattgggatg actatggata gaatttaacc tgaaaacact 1380 gaagttgaca gctgacaaag 1400 <210> 152 <211> 250 <212> DNA <213> Homo sapiens <400> 152 tgcttcaacc ggaaatgtgg ttgaattacc cttacagtga acctgatcag tggtaacagg 60 agatgctaga acaggaaaag acaagtttcc cctttcctcc ctatcccatc aattactttg 120 aggtgtattt tttctttgca acccctccag agaagtcggc aatgtttaac gagcatgcct 180 gccaagtggc ttgccttata cctcattatg aagtgatact cagggccact aacacatcgc 240 acagcattgc 250 <210> 153 <211> 500 <212> DNA <213> Homo sapiens <400> 153 tatgattccc tcgatttccc tcaatcttaa ccattgtgga tcacagcagg agggccagaa 60 agtgagcttc agcctggcac cgggacctca gcctctccct taaactttcc ctaatcctcg 120 gagctagtgt tactcaagtg actccacagt gttgcccgat cccttcagac atggccttga 180 tgatctccaa aactcatgct acctttgcca gcctaaagca tccactctgt gccccaaaac 240 gtgaatgtca aatacccttc aaggcagaag gctatttcta tttttgtttg tttctgttta 300 aggcaacaat caccaacatt tggtacacat gagccatcct gtgaaacatc aaggcgcttc 360 gttggcagca agtcaacttc ggtttcagaa gaaagctgca ctatttcctg aggttagagg 420 tttaaaccaa aacaagacaa ccacatttta accccaaatc tgccgactga gggtaaccat 480 gatccttcct tcacagcacc 500 <210> 154 <211> 150 <212> DNA <213> Homo sapiens <400> 154 tactaaatca acccaaaccc gagaacccgg tcatggagaa ataaatgata gtaatctatg 60 ctgttcatct gttccatcac tcactcactc tcttgctgaa caagaaaggg ccacccatgt 120 agcaaaccac atgtaaagag ccgggaagac 150 <210> 155 <211> 300 <212> DNA <213> Homo sapiens <400> 155 tattattttg ttcaaagtag acgggtatac taacatctgt gggcaagttt accacacgcc 60 acttaaaaca ggctaacagg gtcatatgcc aaaacgttca ggtttgcatt tttgaaaagc 120 tcagagatct gacagatgtg ttccggccgc gatttaacat gcggctccag tgagaaggaa 180 gcagatatga caaatggttc acttatttca gaactaaaac cccagaggag cagcctgagc 240 caaaaaggga agtgatcaat ggaaaagacg gtcgaatctg ctcacaggca aggcaagggg 300 <210> 156 <211> 400 <212> DNA <213> Homo sapiens <400> 156 gcaggggtga ctggtcctct ctctctgcac ctcgcaggat ttctctggaa gatctgagcc 60 cgagcgtcgt gctgcacatg accgagaagc tgggttacaa gaacagcgac gtgatcaaca 120 ctgtgctctc caaccgcgcc tgccacatcc tggccatcta cttcctctta aacaagaaac 180 tggagcgcta tttgtcaggg gtaagtgcga ccctagaggc gatcgtctct gctgtctgtg 240 gaaaaaagag ctcctacacc caaagtgctt ctcagttgct gacacttgat ccaagctgct 300 aatttaatct aatgtgaggc tgagttttct gaatgtggga taaagtcgta gctaaacctg 360 cttctcaggg agtgcctttt atctgcaatg tttttcaaat 400 <210> 157 <211> 10000 <212> DNA <213> Homo sapiens <400> 157 gtctttcccg cccccttgtc taaactcaaa accgagtccg ggcgcgcctt gcagggcgcc 60 cgagctctgc agcggcgttg cgggctgaac ccatccggca caaactgcgg gccactggcc 120 cctcacacct gggagtttgc ggcgctggcc tgcagcccgg ggcccacgtg gcggaagctt 180 tcccgggcgc gcgctgcgca gccccgcggg gccggggaga caccgctcgg gagtcctccg 240 ctcggctgca gaatctttat cagctgcact ttaccgcagc cctggctagg acgctaggcg 300 gtggagcgcc ctatccaggt gcgccgccgc accatggatc accgcgcccg gtcccgcagt 360 cccgccatgg cctggggagg cccgaagccc ggggacagtg gccggcccat ctccggctcc 420 gcggaccccc ggctcaggcg ggagggcagg cgggtccctg caggccccca gggagcccgg 480 gagcctctct ctggcgtcat tcagtcccgg ggcaacctga agcgcggtag atattggaga 540 gggggcgtct gttgggggga cctggcgtca ttactgatgg ctagcaggga ggagggaacg 600 ggttgtcacc tcggcctcat aaggccgtga gtgagtagtc cagggcctct tcaggcattt 660 ttgaaactgg attaactagg ggggaaattg tagcactgaa gccaccgtga ctgtcttttg 720 cgctgtgtgg aaactccggt aaaactcttt gggcaacagt cttatcacca gctcttcaac 780 gtgtgcagcc cttctggtcc tgtccctgtt ctgggcccca ggaatgcaaa gcaggtccag 840 gcactgtgaa gaccctggcg gtggaggaag aggcttcccg gctgtggagg aagccagacc 900 cttacaacac aagacgagaa ccagacctgc gtgggggagc tctggatgct acaggggctc 960 aaggaggggt ggaggggcct tcccaggcca acccctgaac ggcttggaca agatgctcag 1020 atggacggga ggaacggcgt gtgggatggg ggagctggag gcgggtgggt ggggggggga 1080 ggatggggaa agcgctggcc cacccagtgt gggaggggta gaggaaaagc ccgcaggggc 1140 caggttggga ccccgtaggc cgggttagag ggcttggact tgatcctgac aggcgacagg 1200 gagacatatt gctacttatt atgtgcacag tggccagatc tctaaagaaa acaccatccc 1260 ccacccccac cccccatata gtaaaccagg tggtccgccc agtgctccca gggaggtgat 1320 gggaaatccc actccatacc ctgcggtgag gggttccatg ccctccacgt gtgcaactac 1380 tccgggccca gggaaacact gggccccatc cggtaacccc cggcccagtc gggtttccca 1440 gttcacatta taaccaaacg gtcttgccag ctagacagac agacacccct gacctgttta 1500 ccctgatcct ctgctctcag gattaatcac aacttgtcga agggggtggc ttccagtggg 1560 gtggaccgct ctgtcaatgc cagcgtgtgt ctagcatctc ctggggtggg ggtgtgggga 1620 agggaggtgt aggatgaagc cctagaagcc tcaggcaatt gtgatccggt gggctggata 1680 ctgaagccca cccctgcctt gacctcaatt ttcagtatct tcatctgtaa aatgggaaca 1740 acctgccttc ctcctagccc taaaggggct gctgtcaaga ttggctgaga tagctgtttg 1800 caagctgagc tcaatgaaag ttcattgtgt ccccctcagt cctatcccaa tatcgtctca 1860 ctgcaaaggt ggggggcagc ttaacttcaa gggcacttca aggatagcca ggtggctgtc 1920 agcccagctt tccaggatgg gagcaggatc ttgacagaag ggttgactgg gaggggcagt 1980 tgctggtttg ggcttcgtta ggttgcattt ttgtttgttg tcctttcatt tccctggggc 2040 agcacccctt cctgcaagct ccaggccttc ctctggaatg ctcctagagc ccaacctctg 2100 ctggtgcctg agcttaagcc aggccagcta aggggatcct ggattcacac ggcctcacag 2160 tcactcagat tgttagcaga agacaaaaat tacaagggga gggcgtcatg tgattcttac 2220 acaccctcca aatccagcag acaccttgga agccacaggt agcttcaaga aacccatttt 2280 acggatgaga acctgagatg gagaaaggac aactggagat ctctgagtct ctgagcccac 2340 actccctacc tccctgcacc tccaggcact ctgctggcag gatcttgggc aaatgcccac 2400 agctctctga gagtcagttt tcctgtctgt aaaatgggag tcataccttc ctcctatggc 2460 cggtgagaga ctaaattaaa ctatgtctgt caagacacct gaaactcctg gcacaattta 2520 ggttgccttc aagtggtcac agttgtcatt aggtggaagt caacacccca atcattgtaa 2580 aggtgcccat ataccccaag atccagatta cagctctcac agtttattat atacagcgaa 2640 aaaacacata acacaccttt gcccacattt acatgtattt tacggaccat gtttcacatc 2700 agtccgcatg cacatctgca cgtgtgtgca ttcggcagta tttaccaagc acctgccaag 2760 tgccagggcc tgtcctccgc acccggcgtg aactgtcctg gaccagtccc gggagccgcg 2820 gttctgacca gccgtgctga ccctggacga ctccatgagc tgttttgtga gaaagacacg 2880 ccatttgttt gcagagttct gacttctgag gggtcatgta gcacatgttt ggtagccaaa 2940 cgctgtcatt cacgaccagg agcgatggct gcaatgcctt tttctttgct ttgctttccg 3000 gtgccgggag ccttgcctcc cgccgccacc cctggtcagc tctgcgcaag aacgtcgttc 3060 tgtttggcag ccaggccgag acgcagcctg aatgtgagca ggaactcgga gaagggaagg 3120 gagagaatca gaaagaaggc ccgggaggga cccgggaagc agtgggaggt ctgcgccctg 3180 gagccccgcg agagcccgcc ggtttggcac gggctcctcc cgggccgccc ggcggtccaa 3240 caaaggccgg ccccgacacg cacccggtct tttgtgggag agaaacacaa agaagaggga 3300 aaaacacgga ggaggccaac agcaccagga cgcgggggcc aaccaggaac tcccggagcc 3360 ggggcccatt agcctctgca aatgagcact ccattcccca ggaaggggcc ccagctgcgc 3420 gcgctggtgg gaaccgcagt gcctgggacc cgcccaggtc gcccaccccg ggcgccgggc 3480 gcaggacccg gacaagtcct ggggacgcct ccaggacgca ccagggcaag cttgggcacc 3540 gggatctaat ttctagttat tcctgggacg gggtggggag gcataggaga cacaccgaga 3600 ggtactcagc atccgattgg caccagggcc aagggagccc aggggcgaca cagacctccc 3660 cgacctccca agctactccg gcgacgggag gatgttgagg gaagcctgcc aggtgaagaa 3720 ggggccagca gcagcacaga gcttccgact ttgccttcca ggctctagac tcgcgccatg 3780 ccaagacggg cccctcgact ttcacccctg actcccaact ccagccactg gaccgagcgc 3840 gcaaagaacc tgagaccgct tgctctcacc gccgcaagtc ggtcgcagga cagacaccag 3900 tgggcagcaa caaaaaaaga aaccgggttc cgggacacgt gccggcggct ggactaacct 3960 cagcggctgc aaccaaggag cgcgcacgtt gcgcctgctg gtgtttatta gctacactgg 4020 caggcgcaca actccgcgcc ccgactggtg gccccacagc gcgcaccaca catggcctcg 4080 ctgctgttgg cggggtaggc ccgaaggagg catctacaaa tgcccgagcc ctttctgatc 4140 cccacccccc cgctccctgc gtcgtccgag tgacagattc tactaattga acggttatgg 4200 gtcatccttg taaccgttgg acgacataac accacgcttc agttcttcat gttttaaata 4260 catatttaac ggatggctgc agagccagct gggaaacacg cggattgaaa aataatgctc 4320 cagaaggcac gagactgggg cgaaggcgag agcgggctgg gcttctagcg gagaccgcag 4380 agggagacat atctcagaac taggggcaat aacgtgggtt tctctttgta tttgtttatt 4440 ttgtaacttt gctacttgaa gaccaattat ttactatgct aatttgtttg cttgttttta 4500 aaaccgtact tgcacagtaa aagttcccca acaacggaag taacccgacg ttcctcacac 4560 tccctaggag actgtgtgcg tgtgtgcccg cgcgtgcgct cacagtgtca agtgctagca 4620 tccgagatct gcagaaacaa atgtctgaat tcgaaatgta tgggtgtgag aaattcagct 4680 cggggaagag attagggact gggggagaca ggtggctgcc tgtactataa ggaaccgcca 4740 acgccagcat ctgtagtcca agcagggctg ctctgtaaag gcttagcaat tttttctgta 4800 ggcttgctgc acacggtctc tggcttttcc catctgtaaa atgggtgaat gcatccgtac 4860 ctcagctacc tccgtgaggt gcttctccag ttcgggctta attcctcatc gtcaagagtt 4920 ttcaggtttc agagccagcc tgcaatcggt aaaacatgtc ccaacgcggt cgcgagtggt 4980 tccatctcgc tgtctggccc acagcgtgga gaagccttgc ccaggcctga aacttctctt 5040 tgcagttcca gaaagcaggc gactgggacg gaaggctctt tgctaacctt ttacagcgga 5100 gccctgcttg gactacagat gccagcgttg cccctgcccc aaggcgtgtg gtgatcacaa 5160 agacgacact gaaaatactt actatcatcc ggctcccctg ctaataaatg gaggggtgtt 5220 taactacagg cacgaccctg cccttgtgct agcgcggtta ccgtgcggaa ataactcgtc 5280 cctgtaccca caccatcctc aacctaaagg agagttgtga attctttcaa aacactcttc 5340 tggagtccgt cccctccctc cttgcccgcc ctctacccct caagtccctg cccccagctg 5400 ggggcgctac cggctgccgt cggagctgca gccacggcca tctcctagac gcgcgagtag 5460 agcaccaaga tagtggggac tttgtgcctg ggcatcgttt acatttgggg cgccaaatgc 5520 ccacgtgttg atgaaaccag tgagatggga acaggcggcg ggaaaccaga cagaggaaga 5580 gctagggagg agaccccagc cccggatcct gggtcgccag ggttttccgc gcgcatccca 5640 aaaggtgcgg ctgcgtgggg catcaggtta gtttgttaga ctctgcagag tctccaaacc 5700 atcccatccc ccaacctgac tctgtggtgg ccgtattttt tacagaaatt tgaccacgtt 5760 ccctttctcc cttggtccca agcgcgctca gccctccctc catccccctt gagccgccct 5820 tctcctcccc ctcgcctcct cgggtccctc ctccagtccc tccccaagaa tctcccggcc 5880 acgggcgccc attggttgtg cgcagggagg aggcgtgtgc ccggcctggc gagtttcatt 5940 gagcggaatt agcccggatg acatcagctt cccagccccc cggcgggccc agctcattgg 6000 cgaggcagcc cctccaggac acgcacattg ttccccgccc ccgcccccgc caccgctgcc 6060 gccgtcgccg ctgccaccgg gctataaaaa ccggccgagc ccctaaaggt gcggatgctt 6120 attatagatc gacgcgacac cagcgcccgg tgccaggttc tcccctgagg cttttcggag 6180 cgagctcctc aaatcgcatc cagagtaagt gtccccgccc cacagcagcc gcagcctaga 6240 tcccagggac agactctcct caactcggct gtgacccaga atgctccgat acagggggtc 6300 tggatcccta ctctgcgggc catttctcca gagcgacttt gctcttctgt cctccccaca 6360 ctcaccgctg catctccctc accaaaagcg agaagtcgga gcgacaacag ctctttctgc 6420 ccaagcccca gtcagctggt gagctccccg tggtctccag atgcagcaca tggactctgg 6480 gccccgcgcc ggctctgggt gcatgtgcgt gtgcgtgtgt ttgctgcgtg gtgtcgatgg 6540 agataaggtg gatccgtttg aggaaccaaa tcattagttc tctatctaga tctccattct 6600 ccccaaagaa aggccctcac ttcccactcg tttattccag cccgggggct cagttttccc 6660 acacctaact gaaagcccga agcctctaga atgccacccg caccccgagg gtcaccaacg 6720 ctccctgaaa taacctgttg catgagagca gaggggagat agagagagct taattatagg 6780 tacccgcgtg cagctaaaag gagggccaga gatagtagcg agggggacga ggagccacgg 6840 gccacctgtg ccgggacccc gcgctgtggt actgcggtgc aggcgggagc agcttttctg 6900 tctctcactg actcactctc tctctctctc cctctctctc tctctcattc tctctctttt 6960 ctcctcctct cctggaagtt ttcgggtccg agggaaggag gaccctgcga aagctgcgac 7020 gactatcttc ccctggggcc atggactcgg acgccagcct ggtgtccagc cgcccgtcgt 7080 cgccagagcc cgatgacctt tttctgccgg cccggagtaa gggcagcagc ggcagcgcct 7140 tcactggggg caccgtgtcc tcgtccaccc cgagtgactg cccgccggag ctgagcgccg 7200 agctgcgcgg cgctatgggc tctgcgggcg cgcatcctgg ggacaagcta ggaggcagtg 7260 gcttcaagtc atcctcgtcc agcacctcgt cgtctacgtc gtcggcggct gcgtcgtcca 7320 ccaagaagga caagaagcaa atgacagagc cggagctgca gcagctgcgt ctcaagatca 7380 acagccgcga gcgcaagcgc atgcacgacc tcaacatcgc catggatggc ctccgcgagg 7440 tcatgccgta cgcacacggc ccttcggtgc gcaagctttc caagatcgcc acgctgctgc 7500 tggcgcgcaa ctacatcctc atgctcacca actcgctgga ggagatgaag cgactggtga 7560 gcgagatcta cgggggccac cacgctggct tccacccgtc ggcctgcggc ggcctggcgc 7620 actccgcgcc cctgcccgcc gccaccgcgc acccggcagc agcagcgcac gccgcacatc 7680 accccgcggt gcaccacccc atcctgccgc ccgccgccgc agcggctgct gccgccgctg 7740 cagccgcggc tgtgtccagc gcctctctgc ccggatccgg gctgccgtcg gtcggctcca 7800 tccgtccacc gcacggccta ctcaagtctc cgtctgctgc cgcggccgcc ccgctggggg 7860 gcgggggcgg cggcagtggg gcgagcgggg gcttccagca ctggggcggc atgccctgcc 7920 cctgcagcat gtgccaggtg ccgccgccgc accaccacgt gtcggctatg ggcgccggca 7980 gcctgccgcg cctcacctcc gacgccaagt gagccgactg gcgccggcgc gttctggcga 8040 caggggagcc aggggccgcg gggaagcgag gactggcctg cgctgggctc gggagctctg 8100 tcgcgaggag gggcgcagga ccatggactg ggggtggggc atggtgggga ttccagcatc 8160 tgcgaaccca agcaatgggg gcgcccacag agcagtgggg agtgagggga tgttctctcc 8220 gggacctgat cgagcgctgt ctggctttaa cctgagctgg tccagtagac atcgttttat 8280 gaaaaggtac cgctgtgtgc attcctcact agaactcatc cgacccccga cccccacctc 8340 cgggaaaaga ttctaaaaac ttctttccct gagagcgtgg cctgacttgc agactcggct 8400 tgggcagcac ttcggggggg gagggggtgt tatgggaggg ggacacattg gggccttgct 8460 cctcttcctc ctttcttggc gggtgggaga ctccgggtag ccgcactgca gaagcaacag 8520 cccgaccgcg ccctccaggg tcgtccctgg cccaaggcca ggggccacaa gttagttgga 8580 agccggcgtt cggtatcaga agcgctgatg gtcatatcca atctcaatat ctgggtcaat 8640 ccacaccctc ttagaactgt ggccgttcct ccctgtctct cgttgatttg ggagaatatg 8700 gttttctaat aaatctgtgg atgttccttc ttcaacagta tgagcaagtt tatagacatt 8760 cagagtagaa ccacttgtgg attggaataa cccaaaactg ccgatttcag gggcgggtgc 8820 attgtagtta ttattttaaa atagaaacta ccccaccgac tcatctttcc ttctctaagc 8880 acaaagtgat ttggttattt tggtacctga gaacgtaaca gaattaaaag gcagttgctg 8940 tggaaacagt ttgggttatt tgggggttct gttggctttt taaaattttc ttttttggat 9000 gtgtaaattt atcaatgatg aggtaagtgc gcaatgctaa gctgtttgct cacgtgactg 9060 ccagccccat cggagtctaa gccggctttc ctctattttg gtttattttt gccacgttta 9120 acacaaatgg taaactcctc cacgtgcttc ctgcgttccg tgcaagccgc ctcggcgctg 9180 cctgcgttgc aaactgggct ttgtagcgtc tgccgtgtaa cacccttcct ctgatcgcac 9240 cgcccctcgc agagagtgta tcatctgttt tatttttgta aaaacaaagt gctaaataat 9300 atttattact tgtttggttg caaaaacgga ataaatgact gagtgttgag attttaaata 9360 aaatttaaag taaagtcggg ggatttccat ccgtgtgcca ccccgaaaag gggttcagga 9420 cgcgatacct tgggaccgga tttggggatc gttcccccag tttggcacta gagacacaca 9480 tgcattatct ttcaaacatg ttccgggcaa atcctccggg tctttttcac aacttgcttg 9540 tccttatttt tattttctga cgcctaaccc ggaactgcct ttctcttcag ttgagtattg 9600 agctccttta taagcagaca tttccttccc ggagcatcgg actttgggac ttgcagggtg 9660 agggctgcgc ctttggctgg gggtctgggc tctcaggagt cctctactgc tcgattttta 9720 gatttttatt tcctttctgc tcagaggcgg tctcccgtca ccaccttccc cctgcgggtt 9780 tccttggctt cagctgcgga cctggattct gcggagccgt agcgttccca gcaaagcgct 9840 tggggagtgc ttggtgcaga atctactaac ccttccattc cttttcagcc atctccacta 9900 ccctccccca gcggccaccc ccgccttgag ctgcaaagga tcaggtgctc cgcacctctg 9960 gaggagcact ggcagcgctt tggcctctgt gctctttcct 10000 <210> 158 <211> 100 <212> DNA <213> Homo sapiens <400> 158 tttttaatgc tcagagaagt tcgtattact gattcgggaa cactgagttt ttcagctcct 60 gtaaaactat tttcaggttt attttcaagt acattcttta 100 <210> 159 <211> 400 <212> DNA <213> Homo sapiens <400> 159 caccctagag gcaaggacgg ggtctgtgtc aagaggcttc ccagagaagt gaaaactctg 60 caggtgcagc cgctgggaga gcatcaagaa gggcagggtg gaggggcagg gggcgaaggg 120 agggggtgaa gcccgcaccc tacccccaca tgaaactgat tccactaccc catctctgca 180 agcgtccaga ggcagagagg ccaacatttc ggggacagct tggaggcggg agatttaggc 240 agggctcctt aaacttttat gtgcatgaaa atcaggccaa tcacggggct cttgagcaaa 300 tggggacgat gattcagcag gtctgggctg aggcctcaga ttctgcactt ctaacaagtt 360 cccaggtggt agtgatgctg ccagtccaaa gaccacactg 400 <210> 160 <211> 5000 <212> DNA <213> Homo sapiens <400> 160 tgcttcagtg gggtaaactt gaaccgctga gaagacaagc agggagtcgg tctcgctgag 60 atttttacct gtggttctag gaacgcagag gcatgtgagt gttcaggctt tgcatagacc 120 actaagccac ttctaagaac aaggctacct gagccatttt gcaaaaatat gtacgtgccg 180 aggcttttcc tccccacacc tacctcaact ctttctgccg acacactgca cttttcaagg 240 gaacccaagt ttgggttcgg caagaattgt acgttgcaca ccgtgtgtga taattccagg 300 gaatttcaat cgcatcttgt cttccttcct aagcaaattc ggtgggaacc tggtgtggtg 360 tgatagaaaa agccccgagt tctctgtggt agaccacatc aatttcatgt gccagtctct 420 cagactccgg cttgcctctc tcaaggaagg gaacaatggt ttgcttggct tcactcctct 480 ctttcccccc aatttccaca tgggtatctg gctaaaaatg agttacaggt ttccttctgt 540 gagaattgca tggactgata aagtaccatc ccaggaagaa aacaaagatg ctgtcttccc 600 tttcggctca cagttgccgt tggggaggga acacacgctg taaattatag gcagccagaa 660 gtgaccgcat tgaccactgc gagtggccca gctatggcaa caggctgaga actctggggg 720 agagccattt gttggcaggg atggtgattc ttctagcatc aagctctaag atgatgacca 780 aacggtatca aaagaaatga tattttgcta cctctccggc ttgggtgaat gatgtggaca 840 gttaacctgg acaatttaaa cctttatgtt gatggatcac ttggatgaaa ttaaccagga 900 aattgccaag atttcacttg gccctctgac atcaaatctc aatattatat taccaaatta 960 gagattctaa agaaccctga gttcctttca ctgaaaggaa ggagtggaaa aacctttcca 1020 gatgatccct tttgagtctt ggtgcgagct caggccctcc ctacactgcc tccgtgaaag 1080 ctaaccgacc cttgttccta acctagcgca ggtcagctga gtgtccatcg ggcacaggag 1140 ccctgggctt gtccgggaga tagccagact cctgctattt cctgatgtct gcatagctca 1200 gcgtgtccct caccatcttt gccgttggcc agtaaggaga gccccagggg ccagcactgc 1260 acactgaaac ccaacctatt gctcaatgga atgcttaaaa atttcctgaa tctgccttcc 1320 tgagttgata aaataggaaa caatacacgt tctgaggggg tactgaaagc agagtaaagc 1380 caggaagatc ttttttttct gttattctat acaaatattg cttcctctgc ttgttagcag 1440 cccagaggaa atgcagccag ggagccgttt gcagcttttc accagtggcc ggtgtctctg 1500 tgttaccaac caaacgacgc tgcaagacta gtgactaacg cacgtctgca tgattcaact 1560 tcactaaaat tccctctgct gccagtaaag aagcacttga aaactcttta atttgaaact 1620 tgagcttggt taatgacttg ttttcttctc tttctcttta acttctctct tgccatctcc 1680 aacacacaca cacacacaca cacacacaca cacacacaca cacacacact ctctctctct 1740 ctctctctct ctctctctct ctctcatcaa gttttttaat ttcagggacc cggaaacata 1800 cagccccgtg cattcacaat agcatttgct gtgataaagt ggccggcaag ccctctgcat 1860 tcccctgctc acttagctgt atgaataaat aatgagtcac agatacaatt tgggtgctca 1920 agagagtttg tagccagaaa attaattatt ctcccatccc agcccactcc atctcagctt 1980 tgccaaacca tcaagataca ctttgcaggc actggtcaga gtgcgtgccc cgacgcacac 2040 ggcaatgcct ttgagacatt ttatgttatt atttttgttt gtttaagcac agccctcttt 2100 taccacgaaa gatacacaag acgcacatgc acacacatac tcacacactc acagctcaac 2160 cacagctttg tccatttcaa gaggctggtt tcaaaaatgg agacaggttt tccaccctgg 2220 ctgttcctat tcataagcct gtaatctaac gacttaagct gcgagaatgc ttaactcggg 2280 aaacttctct attgcccttt tccagagaga cctcggtatg ccacaatttg cttcctttct 2340 ctcttgaaag atgctggttg tctctttgca ttgaggctac aaggaaaaac acagcacagc 2400 cccatgctga tgattttaac ctaaccaagt ctgtcagtct cctgtactct ctgccttata 2460 gagacagctg ccttgccact ttggccctga agtccccagg ctggtgcaag gctatctgag 2520 agcctccgcc tcctgcccca cactggcacc agccctcctg gctggctctg tgcatgtgcc 2580 tgctaagccc cagggcaggc tgcattctgg gccacacagc atgccgagtt aaggataact 2640 cagacacagg cattccgggc aagggacagc aaaataaaac ccagggagct tcgtgcaagc 2700 ttcataatct ctaagccttt aaacaagacc agcacaactt actcgcactt gacaaagttc 2760 tcacgcaccg actgaacact ccaacagcat aactaagtat ttattaaaac atttctgaag 2820 agcttccatc tgattagtaa gtaatccaat agacttgtaa tcatatgcct cagtttgaat 2880 tcctctcaca aacaagacag ggaactggca ggcaccgagg catctctgca ccgaggtgaa 2940 acaagctgcc atttcattac aggcaaagct gagcaaaagt agatattaca agaccagcat 3000 gtactcacct ctcatgaagc actgtgggta cgaaggaaat gactcaaata tgctgtctga 3060 agccatcgct tcctcctgaa aatgcaccct cttctgaagg cgggggactc aatgatttct 3120 tttaccttcg gagcgaaaac caagacaggt cactgtttca gcctcacccc tctagcccta 3180 catctctctt tcttctcccc tctgctggat acctctggga ctccccaagc cctattaaaa 3240 aatgcacctt tgtaaaaaca aatattcaaa ttgttaaaga ttaaaaaaaa aaaaaaagcc 3300 agcgccgcct tggctgtggg ttggtgatgc tcaccacgct gcgaaaccct gtggtttgca 3360 ttcagtgtga ttcgtcctgc ctgctgacca ctatgctggg ttcagacttc tgacactgcc 3420 aggctaccca acttgtggtt ctgtggttgt ttatgaggcc caaagaagtt ttcacacaac 3480 ccaaattaca aatttaactg ttcccctttc cacagcccat ctcaattggt tcttgccaat 3540 catgtgactt aagtgatgtc aatttttttt tttcttttct gagcaatgcc cttccttccc 3600 tccacctgcc ctcccccagg ctgtgcaaga aaatagccga gtagactttg caagaggggg 3660 ggatgtagaa aaaagtgact cagtcactta ttatatctca atggtctttg ctgatttagt 3720 acaactcggc tcctgttgtt atttgtggtt tttggaacta ctgattattt tgataaagat 3780 ttcattgctg cttattcaat agtaattcaa cgctggcatc aagccgctgc tccgacagga 3840 tgtggatccc atcatttaaa atgctaggca tcagctccgg gagagttaag tccttggtaa 3900 cgtctatcat ggcataagtg aaactataaa agggaaaaat aaataaaaag aaatgttttg 3960 gtgagagtct gacccctaca acgggctggc aactcacagg tattttaaag cctgggaaag 4020 ggaaagaatt ttacttttga aataaaagga ctgttttaat gaaaccaaaa ttatgtggtt 4080 ttattccccc taaatggaca actttagtat gtatctcttt cagtaaagag ataaaatcat 4140 agtacagtct taacacacac acacacacac acacacacac acacacacac acaaattagg 4200 aagctaaagg aaaacaaagc agagagaatt tctgtatttg ggacaaagca gtggttactc 4260 tgcagatgtt tatttgtatt gtcacttggg aaagctccct gtattgcctt tctctagttc 4320 aattcaaatc aataggctaa tttacacctg taggtaaaac tacactttga gcacatgagg 4380 atgccacaat agaaggggaa ccaggaggag acacttctcc tggggctgac taatgaatat 4440 tatatagcgc gtcctctacc ttagaaagac atgcctgttt gaagatgcta aaaacaggat 4500 aattttgtaa gtgggcaaac cactgtggtc acacgtattt cattttccgg ccccactggc 4560 tttacctgct gacaactaaa acgtcatttt gttttgtagt tccaagatga agaaaggctt 4620 attttcctga tttactacct tattcatttg gctctgctct gcctacatcc gccatagcac 4680 tctgcgcacg tgaaatttcg acacataggg tcaagagaac ctgtgtgatg atgggttgta 4740 aatgccagtc ctggattcta agctgcagta gccagcacag gcacttcaga aaggctgaac 4800 tcccacaaca ctccctcggt tttccctcat ccacttaatt tcacacacac aaagacccac 4860 aacgatagta gcttccatgg cacaagtctt tcaaaaggaa cagacacaat ttttacttac 4920 tcctgttttg actaaagcag gaattgaaac tcaacagacc gctttctctt acacttgtga 4980 gaagttagct ggccacatgt 5000 <210> 161 <211> 500 <212> DNA <213> Homo sapiens <400> 161 agggaaaaga gataacgaaa gaaagaaaga aaaaaaaaag ggccggcaat ttcatgtaca 60 tttgttttgg cattcgctga attctagaga tgaaaacaat ctcctgcttt taattcagtc 120 cacgtgcaac aaagttgtac gttgggagat ctggctttta ataagaacga ttaacaagcg 180 tttttgatca caggaagttg agaagagtcg ctgcttctaa gaatacaata aacattgact 240 agcagttaga cggtccatct ttctctatca gccgtttagc agcctctact ttgatttggg 300 gcaaatgcga gatgggacca ggagagagct ccccacaccc ccaccaccac gtgggcagtg 360 gttctgttcc agagcgcctt ccttcctgtc cagggaggca ggctgctgag gccgtttctg 420 ggcaagaggc cattgtcggg atatttgctt tagatagctt gcagctgggc tgagtgggtg 480 tttcattcag actcaacaca 500 <210> 162 <211> 700 <212> DNA <213> Homo sapiens <400> 162 agcctggcgc acccgcccta atttgagtca gggaccctag gcgcctgcag ctccggttcg 60 ggttgagtgc ctcctgtcag gatgtgaagc tgctgtcccc cccgggggcc tccagcactg 120 ctgaggactc agcagtcagc ctctcctccc acttgggctc atttacagag agcatctcca 180 ggaatcagtc atggggaaag gggaaacgcg gagtgacaac acaacacgta gaaagttctc 240 tgccgccttg gtcaggcttg tcagcctcac agcccatcct gctcctgcgg gaggaaaagt 300 gagcagaact cagcccggag atgagccgca ggccggcagc ccctgcctct gccctgcttg 360 ttgtgactgc aatgcaaggc tctctgtagg tgcgggggat tcgggttaaa tgggtctcca 420 gtggtccagc gctcccagca aaggccgacc acaagaatta gcgggctagt tatttaccat 480 aaccatatac aaaaccacaa gcatcagcgt tccctcaaat acatccgaga cgctgtatat 540 ctctttatta aagcctgtca gggtttgtta ttgcacagct tggccttgaa ccccaactaa 600 accaggctgc ttgagcaaag aaccaagcaa tgcaagcatt caggcaggac cattataacc 660 ctgaggccaa aggcagaagc agggagagga gacgtcttcc 700 <210> 163 <211> 500 <212> DNA <213> Homo sapiens <400> 163 agaccagcct cggtcttcgg cctgcgggtt ctgcaaagtc aggctagctg gctctccgcc 60 tgctccgcac cccggcgagg ttccggtggg gaggggtagg gatggttcag ccccgccccg 120 ctagggcggg gcctgcgcct gcgcgctcag cggccgggcg tgtaacccac gggtgcgcgc 180 ccacgaccgc cagactcgag cagtctctgg aacacgctgc ggggctcccg ggcctgagcc 240 aggtctgttc tccacgcagg tgttccgcgc gccccgttca gccatgtcgt ccggcatcca 300 tgtagcgctg gtgactggag gcaacaaggg catcggcttg gccatcgtgc gcgacctgtg 360 ccggctgttc tcgggggacg tggtgctcac ggcgcgggac gtgacgcggg gccaggcggc 420 cgtacagcag ctgcaggcgg agggcctgag cccgcgcttc caccagctgg acatcgacga 480 tctgcagagc atccgcgccc 500 <210> 164 <211> 17000 <212> DNA <213> Homo sapiens <400> 164 cacgcgcccc ggcctggctg gaggggccaa cccagcgggg cccgcctgcc cgccggcctt 60 tctgtaactt tctctcttta aacttccaat gaatgaacgt gcctcttctt acggatttgt 120 ttagattagg gaatagattc ctcgctgata gcgttgcttt gcaaataaga cctcctatat 180 tattcaaacc aaacgagttt gtgtctttaa aggactatag cagccccatt ctatgttaag 240 ggttggctat tacaattatt atatgcttag ggaaaaaatg taagccccgt agtttgtgct 300 tttcttgatg tacagaaagg tttatcttag gtggataggt tttgttttgt ttcttaaatg 360 ggattttttt ggttcgtgtc tttgaagggc tgtttcgcga cgtcattaat gaactaatcg 420 gttttcagat ttcaagacgg tgtgtaattg atgtaaccac tgaggaattt cagtgcacac 480 cagactaaga ctcttccagc gcaggggatt ccagatgctt cttgggccct ctggaagcca 540 tggggatgtt tccagaccga aaggagggct ttgctgggga gcagatgtgc tgcctctccc 600 cgacccagga ttttgaggcc atgtttccgt taatctggac cgagagccct ctgggagagg 660 gaggcaggtc gtagggggcg ggggtgaggg ggagcgagat gaggtcgtcg ctggacgctg 720 ggctcccttg tcgttgtcct tttccccaga atccatggtc aggcctaggg agccacccct 780 gggtgctcga gatgagtccc caccctcact gaaggtcggt cactggatgt ttgtgtgcat 840 cgtaaggggc ccaccgaagt cccgaagcct tctcagggac cagcgagaaa gaggagcagg 900 cttgggagac agggaaggaa aatgcagggg aaagggctca cccctcgacc ccaggtaaaa 960 ttagaaggaa cgtgtggcaa cccaggtgca gctttggtcg ctcgctcaag gactttgcta 1020 gtcactacca ttaattaatt aatcactatc attaactacc aaggacaccg tttttattcc 1080 cctaaaagcg tcaccttgag gggaatggag aattgggcag cagctatgca aatcctggga 1140 caggagacac tgcctgagga ccctctctca ctcccaatcc cagaacccga agttatcccc 1200 gacaaccaag tccaagcaca tgaaccaaga cgatcagctt caggcagctc cttaccccca 1260 caagcggccc aggaggtggg cattatcccc cacccctggg atttctccat ccctccctct 1320 tctctcctgc gggagagaga gctgtggtca cccagttggg cgcgatggct ctggactaat 1380 ggggtctcta gacccagggc acaaaggcca atctgccagg ggttactgca tgtaatgaga 1440 taatcagaca tgttgaccaa cctaaaagaa aagactctcc cagggagtaa ctcccagtga 1500 aataatttat taaaaaaagc aaaaaagaga cataaatttc tctctactac ttgaggaaac 1560 agcaaacaga acgaattagg gtcttggcct ctgcaggaat aaattatttc cgacttggtc 1620 tggatacctg taattatttg taagctgtgg gtagtaatac tgtaattgtc ccccggtcct 1680 ttctggaagt agcaatgacc ccaaggacaa ttggtgacgt ctccacaggg tttacacatg 1740 gaaaggagtg aaaaatcgag gaattctttc agatagccca gaccaaaaat cctctcagcc 1800 atgaaaaggt catatatgtg atgctgggcc aagcggactt ttctggagta accatatcat 1860 aactgattgc ggatgtagac aagagcgtat aaaccaaata ggcttgaatc aacgcagtcc 1920 tggattttct gttgcctctg cttgctgggg cagtggaagt tcttaaactc cacttcagag 1980 gttggaaatt cttccccctc ccccacctcc ttagtgacaa ggtctctgat ctcctgctgc 2040 cactgcaata gcctctccca tcccgcgggg aacggccgga gttcttccct tgatctctcc 2100 cgagtcggct tccgctgggg atggatcgca ggtaggcgcc ggcgcggcct ggggaagaac 2160 agttgcggag catctgaagc ggaaaatcca agcagatgtg aggcgatccg ggcccgcctc 2220 gttcctcttg gggcctgaat ttcttccaga taagtttcct aatggaacat ttctaagagg 2280 tggggtacga ggcggcttgc tcgcacgcgc agtgggacag actgcgggtg gggacgtact 2340 gagaggtccg gacctcaatg cgtccgaccc gtctccacac cgcccttttc cagcccccag 2400 tctcctttca ttccctactc ttcaggctcc tttggggcca gtgggtgaac cgccatttag 2460 aacggtgcct cggactcggg ggtcgtgcgc tccatctctg cctcccccct ggggcccgcg 2520 aggctggtcc gggctttctg agctgggcgt tcggctttag gcccaatacc tggaccagga 2580 atttcttctc cccgcgccag aagggaaaga cataggaggt gtcccaatct gcggtcaccg 2640 ccgatgctcc tgaccactct agtgagcacc tgcccggtac ttttccattc caacagagct 2700 tccagcttca tactaactat cccacatacg gcctgtgggt attagctcta agtgtccttt 2760 tccgagggcc cgaggctccc cctccagcag ggagagctcc gggacggccc ccaccaaggg 2820 ttgggtttct tccttcacaa ttccacagag gcatccctgt ccttcctacc tgggaaacct 2880 cgaggtgcgg tgcccgtgta cttctggtac tttgcgtggt gccatcaggg accccagagc 2940 cacagctgcg tgtgtgtgtg gatgtgtgtg tgtgtgtgcg cgcgcgcgcg tgtacggcga 3000 aaggatgtgc ttgggggagc cgagtacaca acgtctgctt gggcagctgc tgggcaggcg 3060 ttgggcctgg aggtatctca cacccacgta tcttccagtc ttcaaacacg gcattgctct 3120 gcctcccgta gcgcgcttcg aacctgcctc gcggacacgt gaacagaggc tgtccctggg 3180 aagataagtg cgctttcccg taaaatccgg gaaatttgcc ttgaggaaag tttccgttct 3240 tgttacttgt cgggtttctc ccacttccac ttagccatgt ttctgcgatc tgggtaatcc 3300 ctttcaagcc caggaggaat tctcccgggt ccataattga gggtcggaag ccgtgggggt 3360 gagaaacgca ttaaatcctc ccgaagccca ggaggtgcca gagcgggctc agggggccgc 3420 ctgcggaagc tgcggcaggg gctgggtccg tagcctctaa ccccttggag ctccttctcc 3480 cagaggcccg gagccggcag ctgtcagcgc agccaggagc gggatcctgg gcgcggaggt 3540 gggtccgact cgccaggctt gggcattgga gacccgcgcc gctagcccat ggccctctgc 3600 tcaagccgct gcaacaggaa agcgctcctg gatccgaaac cccaaaggaa agcgctgtta 3660 ctctgtgcgt ccggctcgcg tggcgtcgcg gtttcggagc accaagcctg cgagccctgg 3720 ccacgatgtg gactccgcaa ggggctaggg acaggcaggg ggagagcccg ggtttgcgca 3780 caccttccag cccctggagg gagcctgctc ggcttcgaac gccttcgaac ttttgacctt 3840 caaaggagtc cctggaaaag gtcaggagcg cctgctgcag gcacggttgc cgaaggccag 3900 gccttcctgg cgcaggggag ggccagggga gggaagcgga tactcagtcg ctgtccgacg 3960 gcgagttttc ggagcagcag gctcatgatc ccgggccagt ggcgagagca gtgacaccga 4020 gaacccaaat ctccgcgccc ccatccgcgg cccggtgtcc tcccggcccc tgctgacctc 4080 caggtcacgc accccactgc tccacggctc tgcagcctgt ggcacacggc cgagagtccc 4140 cacatgatct cgacgccaag gtaaggaatt gccctgcgtc ctctgagcct gtctctggcc 4200 tggggggccg ggaaagctgc actcctggaa gaggtggggt tatgtgaccg ccgctgcagg 4260 ggtgcgcgga ggactcctgg gccgcacacc catttccagg ctgcgggagc cggacagggg 4320 agggcagagg ggggacaaaa ggactcttta ggtccaaaat gaccctgaag gagagtccag 4380 aatgcccagt ggccgcgtct gcaacggagt cttctttctc caattgcctt ctgccccatc 4440 accatgggcc ccacctgcgc cacctgcgcc caccctgtga ccctggctca gcgaccttgg 4500 cccttaatcg cccaacgccg attcctcaaa attccggctg cgctgaatcg ggctgctttt 4560 gccgccgccc cggcagttgg gccctgtttc cgccggcgcc ctgggagagg cctcaccact 4620 cggctgggct ccctggcccc tcccttcccc tggcctgagc gcccctgcgg cctcccgctc 4680 ctcctgagaa ggcgacaatc tctttgcacc ttagtgtttc gaggacagaa agggcagaag 4740 ggtcacttcg gagccactcg cgccgttttc acgtgtgtgt gtaatggggg gaggggggct 4800 cccggctttc cccttttcag ctcttggacc tgcaacaccg ggagggcgag gacgcgggac 4860 cagcgcaccc tcggaaggct cgatcctccc cggcagggcg cctggccaac gagtcgcgcc 4920 gcctcctctc ggccgcgcct gctggtgacc ttcccgagag ccacaggggc ggcctcggca 4980 cccctccttc cctcgccctc cctgccgccc atcctagctc cggggtccgg cgaccggcgc 5040 tcaggagcgg gtccccgcgg cgcgccgtgt gcactcaccg cgacttcccc gaacccggga 5100 gcgcgcgggt ctctcccggg agagtccctg gaggcagcga cgcggaggcg cgcctgtgac 5160 tccagggccg cggcggggtc ggaggcaaga ttcgccgccc ccgcccccgc cgcggtccct 5220 cccccctccc gctcccccct ccgggaccca ggcggccagt gctccgcccg aaggcgggtc 5280 tgccataaac aaacgcggct cggccgcacg tggacagcgg aggtgctgcg cctagccaca 5340 catcgcgggc tccggcgctg cgtctccagg cacagggagc cgccaggaag ggcaggagag 5400 cgcgcccggg ccagggcccg gccccagccg cctgcgactc gctcccctcc gctgggctcc 5460 cgctccatgg ctccgcggcc accgccgccc ctgtcgccct ccggtccgga ggggccttgc 5520 cgcagccggt tcgagcactc gacgaaggag taagcagcgc ctccgcctcc gcgccggccg 5580 cccccacccc ccaggaaggc cgaggcagga gaggcaggag ggaggaaaca ggagcgagca 5640 ggaacggggc tccggttgct gcaggacggt ccagcccgga ggaggctgcg ctccgggcag 5700 cggcgggcgg cgccgccggg ttgctcggag ctcaggcccg gcggctgcgg ggaggcgtct 5760 cggaaccccg ggaggccccc cgcacctgcc cgcggcccac tccgcggact cacctggctc 5820 ccggctcccc cttccccatc cccgccgccg cagcccgagc ggggctccgc gggcctggag 5880 cacggccggg tctaatatgc ccggagccga ggcgcgatga aggagaagtc caagaatgcg 5940 gccaagacca ggagggagaa ggaaaatggc gagttttacg agcttgccaa gctgctcccg 6000 ctgccgtcgg ccatcacttc gcagctggac aaagcgtcca tcatccgcct caccacgagc 6060 tacctgaaga tgcgcgccgt cttccccgaa ggtgaggcct caggtgggcg gccggggacg 6120 ctggggagcc cggcggcccc ggcccaggcg ggaagcgcaa gccagcccgc ccagaggggt 6180 tgccgcggcc tggcgtccag agctggggcg tctgagggag gttgcgtgag ggtcttcggc 6240 ttcggcgctg gcttggggcg aggggccagg gccttggcgg cccaggcgac caaaccctct 6300 cctggtccag ggctgggtga gggcgaatta cgaattgttc caggggcagg cagtccccca 6360 gcccgcacgg ccagcgagtt ctttctggtt ttgttctttc tccctttcct ccttccttcc 6420 ttcgccagtg cattctggtt tggtttggat ttttttctct ctttctttcc tttctttctt 6480 tctttctctt tctttttctt tctttcttcc tctttctttc attctcccct tccttccttc 6540 cttggccccc tctctccctc cctccttcct tccttccttt gccaatgcat tggtttgttt 6600 tctttccttt tctgctttcc ttcctttctt tggaagttca ctctggtttt gctttctttc 6660 tttccccatc ccttcctttc tttatccctc cttcccttcc tccttttctt tctacgattc 6720 cctttatttt tccttcattc ctccctcttt ttgtctcttc tggaggaggt gaaggagggt 6780 cagcttcagg cgctgcgagt cagcggggat cacggtgagg cccaagcact gcaggctgag 6840 gccacagagc gaacacttgt gctgagccgg gccctctcgt gaggctgggg tgcgggaagt 6900 ccgggcagga gagacccgcc cccgccgttg ctgagctgag acccggctga aagagagggg 6960 tccgattaat tcgaaaatgg cagacagagc tgagcgctgc cgttcttttc aggattgaaa 7020 atgtgccagt gggccagggg cgctgggacc cgcggtgcgg aagactcgga acaggaagaa 7080 atagtggcgc gctgggtggg ctgccccgcc gcccacgccg gttgccgctg gtgacagtgg 7140 ctgcccggcc aggcacctcc gagcagcagg tctgagcgtt tttggcgtcc caagcgttcc 7200 gggccgcgtc ttccagagcc tctgctccca gcggggtcgc tgcggcctgg cccgaaggat 7260 ttgactcttt gctgggaggc gcgctgctca gggttctggt gggtcctctg ggcccaggag 7320 ctgggagggc tgcgccggcc tctggagccc cgggagccag tgccgaggta gggagacaac 7380 ttccgccgca gggcgccgga cggtcggggc agagcaggcg acaggtgtcc ctaggccgca 7440 gggcgcttcc atagcgccat ccccaccagg cactctactc gaaatcggaa agctcgacct 7500 tttgcgttcg cctctgccaa gcctgttatt tgtgctggcc gctgggtctg gagctgcgct 7560 tctcggcccc tccccggtgg agcgcagagg gctggtctgc aagcgcggcc tccagccccg 7620 cggctccccg gcccaggagc caggcgcggg ctgacccggg agcacccggc agcggagggg 7680 gctggaagcg gaccctaggc ctctcctgtg ccacccggcc ctaccgcgcg gccgcggggc 7740 gctctcctct cgggcgcagc ggtccttcag cccagggcag gttcctccct ttcctactcg 7800 gaacgtggca aagatacccc agtcccagcc cctccagctg agagctgttg cccaaggtcg 7860 tcgctacttg tccgctcaat ggtgacccct tggcagagaa ctagggatga ttccactccg 7920 gttgatgttt taggggaaat taaaagaaca ttcggttttc tgagtctcct tccggggagg 7980 cgtggtggta actggtttgc tgggaagagc cgttccttaa ccgcatgcaa caaagcaggt 8040 gtggaatccg gacgagaggg cactcactgc cttctgcccc ctttggaaat agaaaaagcc 8100 ttcgaagcag caatccaaag atcaaatgat ttgcggtcaa tgatttcaat taaaccagaa 8160 attagtaagg gagggccgag aagacacggc tgctcagaag ctgttcgctg tttgagggat 8220 ttcccggaga gcctgttaaa agatgcgaag tggtgggtgt accgctcagc cacctttaaa 8280 ccggctctgt gcgttctggc tctggaaagc aagtctccag gcatttgggc tcagaattgc 8340 tgggccccga gtttgggcgg gggtggtcct tctgggggtc aggccttgag cagcttgcac 8400 tggtggcagg tttgggagca gttgaggggc ttcctgtgtg tcttttggag ggggtgaccc 8460 tggaagttgg cactctggaa gggagctgtt tggccctaga gttttggaaa gggccctgaa 8520 cctgttcggt ccccctcgga aagggaaggg agcagtggct tagtccctcc ctcctccatt 8580 cgtgcaatgc ctggggtagg ggtagacctg gagccggtgg actcatatcc ttggaattcg 8640 tcaggacagc tgctccgggg ccttggccct cagtcagtct ggggctgagg agtagggaag 8700 ctgggaactt ggggcagagg aagaagatgc gtttagaaag acctccatta tgcaaactgg 8760 agtccattta tgcaaactgg tcacccttcc agtagctcca aagagtggca gtggagtggc 8820 atcttgattg atttaacctc ttctcagggg acctgggtct gcgagggagg atatggctgc 8880 ggggttggaa taggatctgt ctgagctgcc agggtcaggg tggtggccct agggaggttt 8940 tagggccagg gtggtcccgg gctgtggcag gggctctcag atcgcctcgg gctctcagct 9000 gcaaggtgaa aaataccatg aggaattgat ctgccaaggg cggtcttgtc tcaaagcaag 9060 tggattgctg gggtaaagaa tctagagacc agcttaggac tctgggagga agaaaaaaaa 9120 aaaaagaata gcatagtcct aaggaactgc aaggatcacc agattaaccc ttcatacctg 9180 gggaaattaa ggccagacat gacacaggcc tttcccaagg ctctgtagca agggcaatag 9240 caggccagtt gctgccactg cggtcctgtg gggcatgttc tcactccact gcacccagga 9300 ggctgccagc ctctgttcct tttaacatag atctcctcag ttgttaagac agaaagagga 9360 actcagaggg gtccctgtgt gcaaggcaga gggagaccac cagaaccagg gtaagcaccc 9420 cacttggtag ccagttcaag gacttgggga tgttttcaac atttacagcg aggtttgagg 9480 ccccattgtc atgcagcgct actcggcctt ggtctcctta tctgtaaaat gggcccatta 9540 gcaatgcaca gggttgctgt gatgaagggt gaggtcccac aagcaaaagc tgtgcagtga 9600 ggggggaatc ctaagcattg ttcctatgcc attcacccct tcctgtgagc tccccatatt 9660 ccctggctca aaggagtctt gaatggcagg gatggaggac tcactgcctg gactttgaag 9720 acccctgctt tctgggtgac caccttttct tccctttgac agtgaactaa tacattggag 9780 gtagatagtg ctgggaagag gacaggagac cacggctgac tttggacatg ggctcgaaat 9840 tgataacttg atgagtcttg gagggtggtt aagataagct cggggctggg gcagcgctga 9900 ggtctgatgg tcagccagcc ctccccaaag tgtggccctc cgttctggag ataggggctt 9960 tggaaactgc aaaagcgtcc tggcaggcca gctctggttg ctccctggcc atagctgctc 10020 tgactacagg cagcaggacg caggtcggcc tctgcccatc ggaggtcaga ggcagggcct 10080 ccagcaccag actcagcagt gccactgcaa acctggcaca acaggctggt cccaggactc 10140 agctcagcag tgaagttgga aaccaaggtt gagtctcccc atctcccttt ccccaacccg 10200 aaagacccaa gatgggtgtg ggtgaaagag ggagaaagaa ttgctactcc agaaactgtc 10260 atttgcccac acgaaacgag gtggggttca aggtctgaac tcttccagtg cctgggtgcc 10320 tttgggttta aattcagctg caggtgcccc catcaccact tccacctgag cacaccacga 10380 gaagccaggt tatcttagaa actgtttccc ggaatcaaag cgacttgatt tggagagttg 10440 ggtgaggaga aactcacccc tatacccctc agggcgtcag agatgtgagg caattctcta 10500 cctccgctgg aaaaaatgca gatttattaa aggtcgactg tttagcagaa caacgtagat 10560 tttttacaac gctttccccg tctctgcttt gaagcctgcc aggctgcagc tggggatcca 10620 ggagggaaag cccgcaggcg cagaggggac aatccgggaa gtggtaaagg ggacacccgg 10680 gcacagggcc tgtgctttcg ttgcaggcga ggaagtggag cgcgcgctgc agattcagcg 10740 cggggctaga ggaggggacc tggatccctg aaccccgggg cggaaaggga gcctccgggc 10800 ggctgtgggt gccgcgctcc tcggagccag cagctgctgg ggcggcgtcc gaactcccca 10860 ggtctgcgca cggcaatggg ggcaccgggc cttctgtctg tcctcagaat acgtaggata 10920 cccgcgggcg acaagccggg ccaggctagg agcctccttc cctgcccctc cccatcggcc 10980 gcgggaggct ttcttggggc gtccccacga ccaccccctt ctcacccggt ccccagtttg 11040 gaaaaaggcg caagaagcgg gcttttcagg gaccccgggg agaacacgag ggctccgacg 11100 cgggagaagg attgaagcgt gcagaggcgc cccaaattgc gacaatttac tgggatcctt 11160 ttgtggggaa aggaggctta gaggctcaag ctataggctg tcctagagca actaggcgag 11220 aacctggccc caaactccct ccttacgccc tggcacaggt tcccggcgac tggtgttccc 11280 aagggagccc cctgagccta ccgcccttgc agggggtcgt gctgcggctt ctgggtcata 11340 aacgccgagg tcgggggtgg cggagctgta gaggctgccc gcgcagaaag ctccaggatc 11400 ccaatatgtg cttgcgtgga gcagggagcg gaagaggcag ccggtcctca ccctcctctc 11460 ccgccacgca catatccttc ttgacttcga agtggtttgc aatccgaaag tgagaccttg 11520 agtcctcaga tggccggcaa cgcgccgagg tcacgctccc cagaaacacc cctctcccct 11580 cccctacccc agctccccct ggggcgggtg gtaattgggg gaggagaggc cgcaggcagg 11640 gaaggggtgg gaaagccaga gagggaggca caaagtgatg gcagcccggc aaacactggg 11700 gcttcgggct gggccgcgct cgtttaatcc cacaaaaatc ccattttgga ggtgagaaat 11760 agaggttaga ggtcgggccc ttctggagat cagaccgagg agacgggccc agctggcgtc 11820 ttaaagcaag gagggggagt cgggaggagg tgagacccct gcacccaggt ggggctccca 11880 aaccgttctg gatttaccac actcccaggt ccgattttcc atggagggct ggggttaggg 11940 actggcacct tcttgttgtt aaccgcattt gatattcaca agaaccctgt gaggagactt 12000 tgtcaccgtt tttagatgcc tgaggttgcc ggaggggcag tgagagaatc gtctaacctg 12060 gtgttcctac cacagtccag gccctgtgtc ctgggctgga cccacagccc ctgccaccac 12120 ccagaggaag gcgcgaagct ggctgcctcc tttacgggtc tcccttaggt gccctcatga 12180 agggggacgg ccacctcaca gtgcaggaac tatctccccg tttgctccca aatagtcttc 12240 ttggtgtggt gctgtctatg gtctgtgacc tgcatctgga gttaccccca ggaccagctt 12300 cggaagagga gggatcgctt ggaggccgtg cagtgtgagg aacggcaggc agggtgtggg 12360 accaacatgc acacactcgc aggtgctggg gccagggagg aatgaggcgc tggctccctt 12420 tccctccatt tctccctggg ggtcccagca acctggccat ccctgacttc caacagcaca 12480 gcgtccccac aggtcctgca gtgctctgca ggggtgcagg gagctcccct ccccccagcc 12540 gcaacctcac cttcctcacc cccacccctc cggcaggaaa ccacaggctg ggttggggac 12600 ccctggtgct ccaagagagc agtgagtgct gggagccgct aaccccgagg cgcctagcac 12660 agactcttct caccccttat ttctgaaata aagcccttcc ttaggtccag atgaggacca 12720 cgtgctcagt gcctcacttt cgtgggagtg tatatcactt tacagtatca agacaatttt 12780 ctttcgttac aaatctttat ttagtctctg cgtttagacc aaagtagatt tttatgggct 12840 gagtgaaaaa acctcgcccg cattggtttc tgatggaaca gctggcagcg ccacggcccc 12900 gggtggggtg gcctagaggc aggggtgctt gggaggaaca tctagcaccc gaccacctcc 12960 accaggtggg aaagggacgt ttgcaccaaa tctccgccgg caaagcagag gctttgggga 13020 attacagaaa aactataatg atctaaaaga gaacaagtta tcttgaactg tgcgggtatt 13080 tgaatcatac agaaaattgt cctgtgtgcc caatgcactt ttgcatgtag agccagggcc 13140 ttcgaggaag ctttcaggag atcccgggca gcggagtctg gtctggagtt tcatttccgt 13200 aggtgcagat ttctccccaa gtcttcccgc catgggcttt gcaagaagcc agggcccaga 13260 ggccacgctc accgttaaca ctgcacaggg caaaggtggc tccaggacaa ctgcccaacc 13320 ccaggaacga cccagcagca gagaaaagga cagctgccag ggtgcctttg tcgctttttg 13380 gaaatcagaa ttcctgggtc cttagttaag tcttacttca ccaaatccca ggaccttcac 13440 attttggttc ttgccattgc taacagttgt aaatgctgcc gccacgaggc ctgggaggaa 13500 ggacccgctg gtgagagcac agggagtgct gctgtgatca cggtggtgat gcggggtgag 13560 cgcgatttcc cgggattaaa aagccaccgc tgcccccgtg gtggaggctg ggggcccccg 13620 aataatgagc tgtgattgta ttcccgggat cgtgtatgtg gaaattagcc acctcctcag 13680 ccaggataag cccctaattc cttgagccca ggaggagaaa ttaaaggtca tcccttttta 13740 aattgaggaa tagtggtttt ttttaacttt ttttttttta ggtttttagt tgccgaatag 13800 ggaagggttt gcgaagccgc tgccctgggc cgaggtgcat tttacgcttc cagaggtcga 13860 ggcctccaga gaccgcgatg cccagggcgt tcccggggag gctgagagac ccagggtgct 13920 ctgggtgact gcacggcgac tcctcgggaa cccactcgtg gctgcccgct tggaagggct 13980 ttgcggcccc gggaacgatc tccaggatct ccacggctgg tcaggttccc cgtccctcgt 14040 atcccgcgct gcccgggggc tcctgccttt ggttcagtgc tcgcggcacc accgcactca 14100 ggacggcagt ggggggctgg ggctggggct gggcctggcc cagcgtgggt tggggcgggg 14160 gacgcgccag cagcgcccgc agctcgctcc gcaggggtcg cagccagggg tcgggagcta 14220 ggctcgtggg ccgggagacg ccgggcgcgt tgtcctccgg ggaggttggg gtgcaggcgg 14280 tgcaccgacc ctcgccatct ggcgctgcag ccaccagcca cggcgcttag tggagggtct 14340 gcggccaggc tcccggcgga aagattccgg ggagggctcg ggggttgtcc cagcccgcgc 14400 taagcgccgc agcctcgccc ggctttcctg cttcctcgga ctgtgcaggg gaagcctggg 14460 gtctcgcggg gcgcagcagt caggtcgagg gtgcagcagg aggggagtcc tgacgggcag 14520 gtccctcttt cccctggtgc gcaacactgg ttggtagctt ttgcggaggt ggtgaagaag 14580 ggcaggaggc ctgttgagcg gaggagtccg gggatcccta attatgtgac aggagaccct 14640 ttccagttcg gcctgtggcc catccctctc tcaccgccgg cagattggag tctgctctcg 14700 gggagccccc aggtaaaccc ctcacaggga gaaggtttcg gattggaagg aggaccgcgc 14760 tcgtggggcg cctgtgagag ctgggaagcc caaggggtag cgtgtagggg gttttttatg 14820 cgggaggagc tgcctcctgg gcggcgggga ctttctgtct cagcctgtct gcctttggga 14880 aaacaaggag ttgccggaga agcagggaaa gaaaggaggg agggaaggag ggtccttggg 14940 ggaatatttg cgggtcaaat cgatatcccc gtttggccac gagaatggcg atttcaaagc 15000 agattagatt actttgtggc atttcaaata aaacggcaat ttcagggcca tgagcacgtg 15060 ggcgacccgc gggagctgtg ggcctggcag gctcgcacag gcgcccgggc tgccggccgc 15120 tgcggggatt tctcccccag ccttttcttt ttaacagagg gcaaaggggc gacggcgaga 15180 gcacagatgg cggctgcgga gccggggagg cggcggggag acgcgcggga ctcgtgggga 15240 gggctggcag ggtgcagggg ttccgcgtga cctgcccggc tcccaggcat cgggctgggc 15300 gctgcagttt accgatttgc tttcgtccct cgtccaggtt taggagacgc gtggggacag 15360 ccgagccgcg ccgggcccct ggacggcgtc gccaaggagc tgggatcgca cttgctgcag 15420 gtagagcggc ctcgccgggg gaggagcgca gccgccgcag gctcccttcc caccccgcca 15480 ccccagcctc caggcgtccc ttccccagga gcgccaggca gatccagagg ctgccggggg 15540 ctggggatgg ggtggtcccc actgcggagg gatggacgct tagcatgtcg gatgcggcct 15600 gcggccaacc ctaccctaac cctacgtctg cccccacacc ccgccgaagg ccccaggact 15660 ccccaggcca cctgagacct acgccagggg cgcctcccga gcgtggtcaa gtgctttcca 15720 atctcacttc cctcagcagg ttccacccag cgcttgctct gtgccaggcg ccagggctgg 15780 agcagcagaa atgattgggc tgctctgagc tctgaagcat tcggccgctg tgtgtgtgca 15840 aggggcgcaa ggacggagag acagcatcaa taatacaata ttaacaggag cacttgtcca 15900 gagcttactg caagccacat tcagttccgg accttattga cttccccctc ccatctagag 15960 tggattctgg tttttcaatt tgttttgttt tgttttttgt ttgtttgttt gtttttgaga 16020 cggagtctca ctctgtggcc caggctagag tgcaatggcg cgatctcggc tcactccaac 16080 ctccgcctcc cgggttcaag cgattctccc gcttcagcct cccgagtagc caggattgca 16140 ggcacccgcc atcatgcctg gctaattttt gtagagacag ggtttcaccc aggctggtct 16200 cgatctcctg acctccgatg atccgcccac ctcagccttc caaagtgttg ggattacagg 16260 cgtgagccaa cgcgtcctgc cttgattctg tttttaactc cattttttag aggaggaaat 16320 tgaggcacag agaggttaaa taacatgtct aaggtcacac agcaaggggt ggagcggagt 16380 tagcccactg gcctagctct agagcccacc cggataacca gaacttggtg aggcctccgg 16440 gctcttgctt ggtttggagc caggtgctta gcgccccgag cccggggcca ttcaccctgc 16500 aggagctgca cgcgcccctg acctcggctt ttccctggca gcagaggggc tttgcgggtc 16560 ggccgggtag ccctgagcac agctcgccac ttccaggtgg gctgttggcg ctggctgggg 16620 acacatcccg atctttcaaa tgccctttac agagcctcat caacgacccg attcattccc 16680 ccctcctgtc atttgtctct gccatcgaaa aatgcctacc gagagctgct ctgcatttcc 16740 gccctctatt ttgtgtttta ctttaaaata ataataaaaa aaatgttggc tgcaggacgc 16800 catgacttag gtcagcgagt cagccgctag ctctgcattt ccaaaaagca gatcttttca 16860 caactctctt gccccaagtg ccctggtgtg gtttattttt taaaatgcat gcctgcggaa 16920 gagaagaccc ggggaatatt cgaaaccccg agcttttaca acataaagcg catggtgtgg 16980 ccgcggcgag taatggcgct 17000 <210> 165 <211> 1500 <212> DNA <213> Homo sapiens <400> 165 caaatcactt gaactcaagt tcaagaccag cctgggcaac atggtgaaac cacatctcta 60 caaaagtaaa gaaaattagc caggcatggt gctgtgtgcc tgtagttcca gctactcctg 120 gggaggtcga ggctgcagtg agccgcaatc acgccacttg tactccagcc tgggcgacag 180 agcaagtccc catctcaaaa aaaaaaaaaa aaaaaaaaaa aaaaggctgg gtgtggtggt 240 cccagatact cagaggctga aaagggagga ttgcttgagc ccaggagttc aaggctgcag 300 tgagctgcga tcacatcaat gcactccatc cagcctgagc aatggagtga gaccctgact 360 atatttaaaa aaaaaaaaaa taggaagaaa caactcaacc acagggctag tatgttactc 420 ggttataaaa tgataaagcc ctaaacagag aattagcccg tttccagaag aggccaagaa 480 cagatgatac agctgaactg aactcctgcc tgtacagctc gttttctaca agattccaga 540 cctggaagat gatggcatcc agcccccatt gaagcacctc gaacaagaaa aacgccgagt 600 ccgaagagcc aggccttgaa cacacgattc ctgtctataa ataactcccc ctggggaata 660 aaaagcagga tccaaggcag gaaacccgag ccgtggaatc tggtaagttc ttaggaaacc 720 cactcacggg cctgagtccc ccgtggaagc ggcgacttcg gcacctggac acccgagtcc 780 ccagagcccc gggcggccgc gcgtccctac ctgcaggcct gataccggcc gcggagcgct 840 cctggccccg ctcccgccag gctccgggac cgctgaaacg cacccagggg ggtgaaggcg 900 tagtcgccaa ggacagcgca gatggcagcg gaggcatggg agccggaacc taccgtggca 960 aagggccagg tcgggacgcc cctcggcgca gccccaaatc ctgcccgcgc cccagccccg 1020 ctcaggccgc gcccctgcca cctctggcca cacgggctga gacgtctggc tcctgcacag 1080 cgcacttccc gctgcccttc tccactggct gctcaggccc tgcctcgcca gcacggcatc 1140 cgcgggggat ccctacctgt cctttagggc ttgcctcata ggtcaaacgt cacctcccag 1200 ggaggtatgg cctgccccct ggccaggtgg gccccttcca cgctcgcctg caacaccacc 1260 cacccacctt gataactgct tgtaaaggtt gtactgcttt cccccttgag actgcaaacc 1320 ttcaagggca ggaaatgggt ctgttttcct ggcaaaataa tgaagttggc ttaaggtttt 1380 gctgaataaa atgagtgaca gacaaaagta gccaaatttg gcactcctga tgggttattt 1440 gatgaaggag gtgcaatgta tgggcttaac tagttattct ggatttcttt ccccatgtta 1500 <210> 166 <211> 200 <212> DNA <213> Homo sapiens <400> 166 caaggccggt gcacgcggac ccgaggattc ggtagatgtc cccgaagacc cgctgccgct 60 ctaaggcggt ggaagcgaga ttctccggaa acccagggaa tccgatgctc gcacaggacc 120 aaagcccgag gccgcgggga ccacagaggg acggagaagc cgggactcct cacatcccac 180 atccggcagg ggaagcccag 200 <210> 167 <211> 2000 <212> DNA <213> Homo sapiens <400> 167 ctgataataa agttttacca ttttataatt taaaaatgta aatatggagt tgggcatggt 60 ggttgggagg ctgagaccag aagatcgctt gagcccaggg gtttgagacc agcctgggca 120 acatgcagaa accctgtctc tacaaataaa aaattagcca agcgtggtag cacgcacctg 180 taatcccagc tactcgggag gctgaggcag gagaatcgct tgagcctggg aggtggaggc 240 tgcagtgagc tgagactgta ccactgcact ccagcctggg tgacagagtg aggctctgtc 300 tcaaaaaaac aaaacacaaa aaaacaaaca aaaaaaagca aatatatgta aaaataggaa 360 gtgcggtttc ccaaaatgag gtctgtaaac aactgatcta gaaaatgttc tggaaaaagt 420 aaaaaaggat caggatctga ggtcaactga cctctccctg cgctctggac aggcaaacag 480 gcaaggttcc ctctgaggcc gtagcggctt ctcgtgggcg agtccctgtt cgcaggtgac 540 gtgtggacca cgctcttccg aagcgtctgg cctgtgtgct ctcggggagg ggacgcaggt 600 cagcccacct agccgatggc taacaagtca gtttgttttc tgaacggaag cttaaaccta 660 gaaaagtaac tgggttgggg tgggggtgta gccacatgca gtaaaagcac tgcctgtctg 720 tataacaacg acctgatgaa aaaaggaacg cgtgaaatgg ggagtgttag ggcgtcacaa 780 actccagtgt ggttgaaatg aaagcagaaa gcaaatggca agctggcttc cccttccagc 840 ttttcacaac cctgccttgc tcatggtcag ccccaagcac gggcggaaga aaggactgga 900 ggggagggaa aggggtgggg agcgagggta ccagaggcgt gggaggacgg ggacaaaggg 960 gcagcaaggg accggcggaa aggaaagtcg gcgttagctg gattggaaac agtccagaca 1020 gaacgatggg ctctgctgcc tccgggtggg gcaccaagcg gggagcgggg ccacgaggca 1080 ggggacagtg aagcaccatg cagcgcccac cagccggcag cgcccaccag cctgcgctgc 1140 gctgcacatg gtacccgcgg ccccagctgg ccagtgtgtg gcggagatga gaccctcgtg 1200 aagagactaa gcggccacag cagggggaag ggttgctcac ataaccccat actgctcaca 1260 ctacgaggtt aactgccgtg agatctgcct gcagccagca gaaacccgtt ctaggaaaac 1320 gttgcccagt gacttcagtg agtgccactg acccgggcgc ctccgccccg gcgtccggca 1380 gcagcaccga ttgcgcagga ggcaccttgc aaacaacctt tcctgatccg cgctgcagtt 1440 cccaggccgg ttgcagccgt ttcacagaga ctgcgcacac aaagcgtctc cgtgccctgc 1500 cattcacctt tcgacacagc cgcaacccct cttttcagtg ttaaaacctg gcgccaaaag 1560 gaacatgcga tgtgacgtgt tacctctgcg catgcgccgg gcattcccag cgccccgaac 1620 ctgatgaacg cgcggtgggg accccaggct tccgtgcttt cgttttcctg gaagctacgt 1680 gtcctcagtc tacatattgt tacctggaaa ataaagtttt ctcctttttt cttcctttgt 1740 taacaggcag aaggtgtagg ctgcaggttt cgggcctaag agagggcatg gctggcgaca 1800 cggagtagac tcctagatga cataacggag gcgagtctgc accggggact cggcattagg 1860 aggaggcaga ggaaaagccc accaccgtgg ccgagggaga tctagcaagc agcttgcagg 1920 gggtgaagtg tgtgcaaagc aggctgagac ctgtccagta tcgaaacacg ccgcggtggt 1980 caagcaggct ttaccatgct 2000 <210> 168 <211> 700 <212> DNA <213> Homo sapiens <400> 168 tgaggctcaa aacaggtgtc tgtgagcttc acaggcggta aggccgtgtc tacatggccg 60 ggacatgcat cccggggctg cccctgccgt gctgcccgag tgcacggggg atgaggacct 120 gacaaggcca ttgatcttgc gggagcttcc tgaactactc cagcgtgaaa atcttccaga 180 aggattctcc acagggcaat gaggcaagaa atttacagct tagcctgatt aatgggccag 240 gcagttaaga gttctttgcc aagctatgag cataatttat agtcatcacg gcaggaggaa 300 aggccacata actcacatcc ttaaagggcc cttagaacaa gagacacgcc ggatcattga 360 aaacgtctcc actcctggcg ccaaaagaga tcggcacgtt tctgggtatt ctggtcaaag 420 aacagggagt ctggattaat atacacggca gaaaaaagcg aagaaaagac acacaggtca 480 tatatttctg actgatattc cgtttgttgt tttcggaggg acttggtatt tatttaacca 540 cattctcact tgacacgccc cctccccaca ccttgtaaat gccttcctct ttagccgagt 600 catttttcat cacatagaat tgaaatgttg ccaggaaggc ggtttatgag attgtagaaa 660 tggcactaga gaaagcagtg tgaaaagagg cctagaacgt 700 <210> 169 <211> 600 <212> DNA <213> Homo sapiens <400> 169 tctctacatg ctatctacta aaaacttagg caaggaaatg catcagacca aacaccccac 60 agcacagaga accgaccggc cattgctttc caatctccgc aaacctaacc attgctggaa 120 gaaatcttac tcacagtgca cagacagtag gtattttatt gaagataaac atatagtgga 180 acaaaccaaa ttacccccat ttgagttacg tgagcactca gttctcagcg tggatgtccc 240 acaaatcaag tcaacatttg cgtcccatta ccagcagcca cttgccgagt atctcttcgc 300 ttccactggg actgcctggc atccctgatg ctaaggagcc actgaagagc ctccaaatgt 360 ctgacattca caaacgcatc ttttgctttg acccgaccct tcaacctctc cgagtctgct 420 gccttttctc agacacacat ccaggcaccg ttagggatag ttagagaatc tgaaaattca 480 gaagcgctcc gaaaagcctt tccaaaagta atccacagca ctcaacagtg aatttagaaa 540 ccccaatttt tttctgagtt tgaagttttt aagccttgcg gatggttgga gtaggaaaaa 600 <210> 170 <211> 1100 <212> DNA <213> Homo sapiens <400> 170 tcagacaagc tctgtgcagt cggaattttt taaagatgca ctgtcacttg aggaagacag 60 gtgatcttcc tgcggcacaa atagaagcaa agagatttct cttcttctct gtagagcaac 120 acaattgata aatggccgat aatctccacc aaattggcag cagtaggctg cccgaaggca 180 gcaggcatat tcgtctttgt gaattgtttt actatgatgc tgtcacattt ccaggaataa 240 gacggttaaa atgatatatt gttgtggttt ggcatttgca gctttgctct gacttccctg 300 gtaactgcca acatctgcaa attattatgt gcttaaaaaa aaaatcaacc gccaccgcag 360 gctgccccca cggtccctgg ctgggccagg cctcctgcca ggccacaggg cagagttctt 420 ggaccaggag gcagcagggt caaaacccag gttgcctagg aagcccccaa agacagttat 480 ggatagagct gggagcccga aacacatgcg gcagtctctc agtttccagg taccggttct 540 cacatcatcc atgcatgtgt ttgaggaaaa acaaaaaaaa attgatggtt gccaaaaaca 600 aaaatgcttc catatcaaag tttatcagtg tcaatgtcaa gagacttctg gttcgtagac 660 tcattttggc ttgaggccac cagaagtgaa ctctggtttc taaatgcaga agcagaggca 720 ctggccgatc atggaagatg cagggaactg ttcaagaggc ccaagcctgg tgctcagaaa 780 cttggcagga tcaagcatct cgcccaggaa ttcatcccct gcttgtctaa gccggctggc 840 tctcgtgact gactcggaac aacagagcag atgtttgcgt gggaggcaag cctcacccaa 900 catctgtcct gcggcgggaa ggcctgggtg ttcacagata gagctggagt tccccggtgg 960 gtggcacaga caattagctg gggctgcctc acatgtaatc taattacagg ggaaacaggc 1020 tcaaacaccg ggtgataagc agcgcaactg tttcgggtga ctctgtaatt tttcctccat 1080 taattttctc cataacgcac 1100 <210> 171 <211> 250 <212> DNA <213> Homo sapiens <400> 171 gttgcctggg atatgcttat atcaaaaact tacgtgtcac ttacctagca tttgcatttc 60 actgggcctc ctaaattctg tgtggtaacc gactgccacc ggacatgctg tttacttctc 120 tatcctcacg cagccagttg ccacattcaa cataacactg caaatattgc cggtggatcc 180 tgacttcctc gtggacccta ctgtgtcggg aaaaacaaac aaacgaaccc tggaaggaaa 240 caccatgagt 250 <210> 172 <211> 600 <212> DNA <213> Homo sapiens <400> 172 tcataaatat ttccaaatgt attcctattt gtctctacag agtctaacag acataaatag 60 cgaattgaag gttctgtctt aaaacccagc agaaagaaaa acaatgacca gaaaaaaaaa 120 acaattgtct ttggcttccc aagaacagca tcggatttca actggaacca cagatggtcc 180 gttgatagaa gcgactactt tttagctctg gaggacgaca aaaggaacca gcttcttcct 240 gtgggtgtca cagcgaggtc gcctggccac atcaggtacc agagcgagcg ccctcacctg 300 ataggccctg tacaacctca gccacagcac tgtcaggagg aacacgcgga actagcaacc 360 taggagggta aaggcggagt tgggagggaa cacgaggcag gcaggtcggc tggctgctga 420 gctacaggct gcactcctag gacgtctacg tgtaattgag aaaaataaga caaaaataac 480 ttactgtgca ggcaattaat tctggttggc atagcgatcc tcttaagtta aagggaatga 540 gcatgagatg aagagaagta agaggcagaa agaattatgc aagagcaaca tcagagtgga 600 <210> 173 <211> 2000 <212> DNA <213> Homo sapiens <400> 173 acgccgagcc gcctctgcag gggaaaccga agcagatgtg gtgagataat acatccaacc 60 ctgagtgcta ctctaacctg ccagaggcgg agggttctca gtgagatgaa agcattacag 120 atgcgttaga tctaagggag gggcctgcag atgcgcagct ggcagagaaa ccagggaggg 180 gctgaactgt cagtcgcgac caccagggat ctgaatcagt tcaccgacag ccttggggac 240 attcaccttg ggctccacaa cctgtcagaa atgcccccaa gcccaaaggc gtcgagagaa 300 tggccaggtt gtttcagatt gacacatatc ctaatgtaca agtcagccca cacaccccac 360 gtgcactgag cgtctcttgt tgttcacccc aaataaactc tgccggaact ggggcgggac 420 tcgcaggggc ggagaagggg ggagacgggc agagggcaga agtggatggt gagaagagcc 480 aatggagggg ccccgtgaga gtgagcaagg ctgcacccct aaccgacgtc ctggggctac 540 tgtacaaaca aagaaccaca ggctgggagg ctgaacaaca gacctgcact ctctcgcagc 600 tcggaggctg caggtctgaa atcgaggggc tgacagcgct ggtttcctct ggaggctgcg 660 agggagaaac cgtcccctgc ctctcccagg ctctggggtg agcccttcct ggcatcccgg 720 gctcattgta gatggatcac tccaatctcc atggcttctc agggcttccc tccatgcacc 780 tcaaatctct ctctccttcc ttttgtaagg atgccagtca ttggatttag gttcacctta 840 aatccaggat gatctcatct aaattacatc tgcaaaaaga ccctttttcc aagtaagttg 900 acattcacag gtacctgggg ttaggattgg acatatcttt tgcaggggtg cagggggctg 960 ccactgagcc cgctgcacag ggtgacctgg gccaagggcc cttcactttc acttcctcat 1020 tggcaagctg ccctgtgttt ggactgggtc gaggctgtca accttgctgc ccctcggagt 1080 cccccctggt gtcccccaaa cagattctaa gctgctttcc tggggctgga ggccaggcat 1140 tgggattttt taaagagctt cccagcaggt gagcagcctt tcatgggtat caggagacct 1200 tcctggcaaa tgtggtgaag gtccttcctc ctgagcgatg ccttagaccc aggagcccag 1260 ggaggctgct cacctgatcg ttaggacagg agcagtggaa acctctggcc tcagaccccc 1320 tggaggaatc cctccctcta agactctggg actggtgcac gcaaggagct atcgtgaaca 1380 ttgctcccaa ctggccgctt gcttgtcccc cggctcccct tggccccagt ggcggctttg 1440 cctgaattag agggcgtgag agccacctgt gtctcagcac tgcaattaaa gcaggaagcc 1500 ctttcggaag cagccgtgtg caccagcctc ccatgggtgg agcagagcaa accacccact 1560 tctgccctct gcccttcttc ccttttctcg acaccctgcg gccccccagt ttcagcagag 1620 tttatttggg gtgaaaaaca agagatgctc agcgcctgtg ggatgtgtgg gctgactcgt 1680 acattaggat gtgtgtcaat ctgaaataac ctggccgtta tatggatgcc ttggggcttg 1740 gggggtttct ggcagtctgt cgagcccgag gtgaatgtcc ccaaggctgc tggtgaatca 1800 gatccctggc gttctccgtt ggcagttcag cccaacagtt tctctgccgg ccgtgcctct 1860 gcaggtccct cctctgatct gattggatta atatttgaat caatagactg agtcaagcag 1920 aatgtgggtg ggcctcatgc aatcagctga agccctgaaa agagcaaaag ggctgcccct 1980 tcccccgagg aggagagaac 2000 <210> 174 <211> 200 <212> DNA <213> Homo sapiens <400> 174 gaatgttcaa agaaagagcc ctccttgcct tcctcttctt ccacccctgc cctctgcaga 60 ctggggttct gtagaccccc aaagtaagtc cgccacaccg gaaggaagtg agttacacag 120 gggcccacat gggaaccgct ttttgtcctg tcttggtggg aaaatggcca cgaccccagc 180 ccaggctctg ccacgccaca 200 <210> 175 <211> 400 <212> DNA <213> Homo sapiens <400> 175 aggcagcagg gttaggactt caacatacaa cttttggggg gagatgtact tcagcccata 60 acacaccacg tgggaggata acaccgattt cagagcttgc agaggaagcc gccaggaact 120 ccagtgagac atcagccccc aggtgcctgt caggcacgcc gggctgtggg gggcacctgg 180 gcccatctga gtaacggagg cgcatccgca cttcccccag gagtacattt ttagaaccca 240 cagcgccata aaccaaagac aaggagactt cctggtgccc cgtcagcttc tggaggcgac 300 gttctcggct gacagctctg gcagcctccc ctgtaggtga gagacaggta aatgggactc 360 ttgcttccaa aacggaacag ggtaaaaatt ctcaagcgtt 400 <210> 176 <211> 300 <212> DNA <213> Homo sapiens <400> 176 ttaaagggga gtggttgtat gaagagttcc tcagtcaaag gtgtgcagct gggaagccca 60 ccccacctaa gagggaggtc tgacaaactg tccacactga accactcaga cctgcatcag 120 ggccccgttt cttccataag ccgccaagta cagccctgag tcaactgaac tcaggcctgg 180 gaggcttccc aaagctgact tgactcagct ttgaactgaa atgaccgtac catgacaacc 240 ctgatgaaaa gctaaactga gcccaattat tcaacagtaa aattcagttg gtctcactca 300 <210> 177 <211> 450 <212> DNA <213> Homo sapiens <400> 177 tgctaccagc tgcttgggct tgggcaagtc accctagctc tcagatgtca tctgtaaatg 60 atgacaatgc caatgtggca ctgttctgag agtcagacag aacgtatgtg tgcttcacat 120 atggtgctca tgaagtgcta tcattatcta aggaaaacag aaaacgaagt tcagagtctc 180 tctaaacgca tgacaccaga ccaacaggga gtttcaaaaa ataggtctga agtaaatcaa 240 ttctcctggt ctcaatacac tgaaaacaaa ctattagggg actgaccgaa cccaccttag 300 gaaccacctt acgtcacctt ctgtctctac tgcaaaaccc tcccttaata ctgttcaaat 360 acgctgacaa tccagatcca tatccaatgg aaccagcaat catgcctgtg tgccagcaat 420 gtcagggagg gaagccgatc tctgatgaat 450 <210> 178 <211> 1300 <212> DNA <213> Homo sapiens <400> 178 caagcctgtg gtagggacca ggtcagagta aacaggaaga cagctttcgg ccaggcggtg 60 cacctcggtg ccggtgagtg tgagcgtgtg tgcgtgtgca cgtgtgcaga tgtgtgtgga 120 cgctcccttc tccgcagcag ctcctgaccc cctgcaggtg accctcagcc agccccaggg 180 ctgcccccac tctcccctgt ggacacctac ctcatttggg gtgaagtggg gggactgggg 240 tgtgaggggt gctttggggg gcacacttcg acccctctct ctgcaggcca agtcctgagg 300 ctcagtttcc tcctctgtgc cccggcgacg tggtgcaggc ctcgcgagtg acgtgagggt 360 tcatgaccca ggtgtgggca gccagccctt cacgggaggc cacccacctg gccacagtgc 420 ctgggaattt aggtcgggca ctgccgatat gtcgccttcc acaaggcggg cccgggcctc 480 tgctgaccgt gcaccggtcc tggggctggg taattctgca gcagcagcgc agcccatgcc 540 ggggaatttg cgggcagagg agacagtgag gcccgcgttc tgtgcgggaa ctcccgagct 600 cacagagccc aagaccacac ggctgcatct gcttggctga ctgggccagg cccacgcgta 660 gtaacccgga cgtctctctc tcacagtccc cttgcgtctg gccagggagc tgccaggctg 720 caccccgcgg tggggatcgg gagaggggca gtgtcgccca tccccggaag gctgagcctg 780 gtgcagccag ggagtgaggg ggcgggaagc cggggtgctg ccctgagggt gccccgacac 840 gctctcctgg ggccctgagc ggctgccacg tgcgtccagg gttctggcca cagggtgggc 900 aggggccctg tgctcctcac tggaggcccc tgaggctctg gaactgagac catccacccg 960 ccggccccct ctcgccggct ccggcacccc tgcctactgt gacttcctgc cccggactcg 1020 ctctgccagc ttggggcaaa ccacttccct ctggggtttt cacttccctc tttcccaagt 1080 ggggaaagac cacctgtccc cgacccagaa agggcccctg cccgagggca gcagcagtgc 1140 caggctggca tgtgaggctt ggggcaggcc cggcccccag aggcacaggg cgatgctctg 1200 tgggacgctg tgtcgtttct aagtacaagg tcaggagagg agccccctga ccccggaggg 1260 gaggagaggc agggcaggaa accgccacca tctcagccca 1300 <210> 179 <211> 200 <212> DNA <213> Homo sapiens <400> 179 gcccactgtg ggtgtgcccg tgtgtgtggc tgtgaggcgt gagtgcaggc gtgaagtgtc 60 tgggagtggg agcgggcatg agtgtgtgcc acgggcctgc tgttgggtcc ttggaggcca 120 cggttgcccc tgaagggact gcaagctctt ttttgatttg tagttatttg agaagtctat 180 acaggaagaa aattaaaccg 200 <210> 180 <211> 1000 <212> DNA <213> Homo sapiens <400> 180 agcgcccagc gcagggccgg gacccagagt ggactctacc gtggggctgc ctcaaagaaa 60 tctcagcaaa cacaggaagc cagcccaccc gtgcagccat ggggccagga agcccgccct 120 ttaccaagtc atttgggcat tttttctctg tgctaacagc ccagatggag ccatagcctc 180 aacctctgtg ttctgataac accaagctgg gacgccggag ccatgcaggg gacagtgccc 240 ggcctgaggc tgcagcctgg gtctggatgc ctttctaatt cagggcctcc tcatggcctg 300 gttccataaa tggtcaaatg cagcctgaca gcgcagcctc ctatcagcgc tgggctccgt 360 accgccacac agcccacata ccccgttccc caggagacgc ccgcaggtgg gcagcgtcac 420 tcccacccgc cgagcacacg ctgtccccgt ctcgtgtccc gaggagccgg aagcagctgc 480 ttcctcccag cctgaaagct gcacctcggg ctgcactcgg ctccccgaac ccgccctccg 540 ctgccctgca attcgccaag ggagctaccc ttcccatata aaaatttcac ctccatttcc 600 ttgtagagaa gaaacatttc tgacagcaag gaagattcta atttgaaaag caagtgattc 660 atctcccggt gccaaacagc agacgcaggc gttaccagtc tgggtggggc gcccgagctg 720 gggacctggg gtcctctggg aggggcaaga aggcagcgat gctggccccc gcctccatct 780 gcccatccca tctgcttcca cacaccgccc tgccgtagct gcttgcagcc cttctctgtc 840 agtttctcca tcttttggtt tggtgataaa tgagagttcc catcgggtgt gccaccctct 900 gtgtgacggg gagcagagaa gaccctgcgt ccaagtcctc ctgggggaag agcgaagatg 960 ctgggaccag ccccagctgt cagggggtct ccaatcccag 1000 <210> 181 <211> 300 <212> DNA <213> Homo sapiens <400> 181 cgcacacaca gcacagacgc ctgcatcttc ccatgcgtgg tttctgctct tgcctctctg 60 ggtttttgtt tcacttcggt cgagtttttg gtggtgttga gcggatagcc ggggaagttg 120 gagtcttgtt tgtggccgcc tcgtgctcgt gtctgtatct aagatcctca ggctgctcct 180 ttttgggtaa ggtctgttgc ttctctagga acagtgacgg tggcagagcc cgtggcccct 240 ctctcctgtc ccagagccaa gctgtttcct ctccccactc ccgggcaccc tgcgggcaag 300 <210> 182 <211> 5000 <212> DNA <213> Homo sapiens <400> 182 aagaggaaat tcccacctaa taaattttgg tcagaccggt tgatctcaaa accctgtctc 60 ctgataagat gttatcaatg acaatggtgc ccgaaacttc attagcaatt ttaatttcgc 120 cttggagctg tggtcctgtg atctcgccct gcctccactg gccttgtgat attctattac 180 cctgttaagt acttgctgtc tgtcacccac acctattcgc acactccttc cccttttgaa 240 actccctaat aaaaacttgc tggtttttgc ggcttgtggg gcatcacaga tcctaccaac 300 gtgtgatgtc tcccccggac gcccagcttt aaaatttctc tcttttgtac tctgtccctt 360 tatttctcaa gccagtcgat gcttaggaaa atagaaaaga acctacgtga ttatcggggc 420 aggtcccccg ataaccccca gctgcagatc gaggcctagt gcgagcacag gtccccccag 480 acccttccca gtgcccacca accggcggcc taggccaggt agaactggca gcgcctcccc 540 tgctgcaaca ccaggctctg gtagaaactt cagaaaacat gcaccggcaa aaccaaggaa 600 gggtggctgc gtcccgggtt cttccgcgca gctgtgtgta cacgcatgca cacacccaca 660 cgcacacacc cacgtgcaca cccccatgca cacgcaccca cttgcacgcc catgcacgca 720 cacacgcgcg tgcacccatg cgcacgcacc catgcacaca cacgcgcgca cacacccacg 780 tgcgcaccca catgtacaca cccacgtgca cacacccacg cgtacacacc cacgcgcaca 840 caccgctgtc cccagccgtg cagaacgatc ctccctgagt ccccggctcc gacccacacg 900 cagcactcgc taaacgcttc ccacgcagtc gttttgctgg gttgcgcttc acccacttct 960 cagagggggc ggccgaggca gaggtgtcgg ggatcgagca gctccgggcc tcaggggtcg 1020 ccccgccacc gttttccttt cccagatgct gggacggggg cagggagggg ctccccaggc 1080 tgaacccgac taggtcaccc tagaagcgag gcgagcttct cttctgtttt tcttcggcgc 1140 ccctgagccc ctgacagtgc ccaagctgcc catgggattg gattcgccag agcctcctac 1200 gcagacccca cccagggcca aagccaaccc caagccccac caccttggtg gtgtgggatg 1260 aaaagtgagc catcgagaga tggggtcccc ccacccccaa cccctccaag gacaaaggcg 1320 ggctgggaag cacccgcttt cacgtccgcc cctgcccggc tttcctagcg gaattggcgc 1380 cggcatcagt tgggggttgt gggatcagtg aggaatcccg tggggtcgcc tccatttatc 1440 agttgtgtgg ggttgggcga gcacccctag ccccagccca ggcgatcagg gcgcgaagcc 1500 cactggacgc ggatttggga ttaggacggg ggtgacagcc aggaggaccg cacctgccct 1560 ccccactcct gccgctccac ccctgccccc accgcaacac caaggtctcc accaggaaga 1620 tgggggtggg gaaaggacgc ggggtggggg ggggtgcggg gagagaggac acagggtcgg 1680 aagggtgagg ggtagtggca gaggcggagg ccgaggccac gcagctgcgg ggcgcaggga 1740 ggggcagagg aggggcgttc agatgggaac ctagtccaga cccgtcgggg ccctcgtgtg 1800 cggctcgtta tcctggaacc agagaggctg gagacccttg gcttgtctgg agcggaaccg 1860 tagtgtccaa tagagtgtgt ggggctcagc cctaaagcta aacattcttt atttcctgat 1920 gaccatgggg gcggagcggg ggaaaagccc tggccttata gtttagaatt ttataaaagg 1980 aaaggcgtgg ccactgacaa tttgcgcttc aggagtccca gagtgaccgc ctggctcgga 2040 gcagggaatg agggggtcct taactctgag atttgttttc tgagagacaa aggtgatggg 2100 tgaggcggct aagcctctga ttctctatag gtggcggtca ttcatttcag aacatgaatg 2160 gattcagtaa ataaacatga tagaaaaatg ccacaagccc taggcccatt ggagtggact 2220 ggacagtctg ttcccagtgt gtccctcagc ctcggtcccc cacccttccc ggagccctgg 2280 gggtcacaca catccctcct ggctgcctag cctgtgcccc ccgattcccc ccctccccgc 2340 cccgcgcgtg cacacacaca cacacacaca cacacacaca cacacacacc acacagcacg 2400 aggcgacaga gatatgagag agagcgagcg agagaggacg ggagagagag ggagtgcaag 2460 tgtgcgctgg gggtaacccg tgcatgcatg cattgggggt aacaggctgg agctcagatc 2520 cctcccccag cccccagcag gggggactgc aggctcctgg tctgagtggg gagctgggcc 2580 ccctggacag aggactgggc tgcggggtca ggaatgggca cacttcctaa ctgcaggaca 2640 ctctaagggc tttggtcatg cacacgcagc caagagaagg tgtcgctggc acacagcctt 2700 ccaggagcgg acttggagac ctcgccaagg accaggactc cccagcactc acactccctt 2760 aggcgctgaa gtccagagga cagaggttga gggcagagct cctgggagca ccagtggaag 2820 taggagggct gggctggaaa acctccccca acctcctatt gcaaagaggc tccagccagc 2880 agcctccaca ccccagtgat cttttaagat gcaaatctgc gccatcattt atttcctcag 2940 tgccttctcc agctcctggg atgcacactg cccgtcccca ggcccagaga cctgaccacc 3000 ctcattcctc cctcagccca ccctggggtc tctccaccag ctgacagcct tcctgcagtc 3060 ccctccccga atgctgctcc ctgaggccct cctggacacc tgcagggcag gcacagcccg 3120 cgggacctca cagcacttgc tccgggcaga gctgcagttt ggccaagttg ccagctccgt 3180 gtgggcaggg gccctggcct gtggctgcca catcccgggt gggggcacgg cctttcctgg 3240 cgtggatgct gagcaaacgt agggggaagg ggagtgaatg aggagagcca ggtagctcag 3300 gggctgaggc ctcactgagc agggtcccgc gtgaccggtc cccaccgctg acggttcctg 3360 gggtaacact caggacaggg agaggcaatg gaaagagacg tggccgccct cgcatcctgc 3420 agctcccgca ctcccagcct cccagcctcc cacccagccc cccagagccc accagtgacc 3480 ccgcccactg ggtcctcaga tggctcccac gggatctcct gccttgatct cctgtccaca 3540 tggaggtgaa gtgggttgct ctgaatgagg ggtgccgagc ctagggcgca gcccactctc 3600 ctgggtccgc agcatcacgc agcccggacc acaggctcct tacaagaatc ggaagggtcc 3660 ctgcaatcgc ccttcgcact gaggcttcct actgtgtggt gtaaaaacac aggcttgtcc 3720 tcccttgctg cccacggggc tggagccgcc tgaaaatccc agcccacaac ttccccaaag 3780 cctggcagtc acttgaatag ccaaatgagt cctagaaagc gagagacgag aggggaatga 3840 gcgccgaaaa tcaaagcagg ttcccctcct gacaactcca gagaaggcgc atgggccccg 3900 tggcagaccc gaacccccag cctcgcgacc gcctgtgacc tgcgggtcaa ccacccgccg 3960 cggctccacg ccgtgggcac agactcaggg agcaggatga gaaagctgag acggcgcagc 4020 cacggcccgg tgccttcacg cgcacagcga cacagcccca gccagcgggg cccacgctaa 4080 ggcggaatcc cacagaagcc tacagagcga gcgcgcgcct gtgcttccca aaacggaatg 4140 gaaccaaggt gacttctaca gaacgatctg aagccctggc tggcccttat gctagtctct 4200 tgggagcgtt ccaaatgcag ctcaatatta cttacttgac ttttatcttt cctccctggt 4260 tcgtggtatt tataactggg tcatctttta actatttgca acgtagcttc aggggagagg 4320 gggagggctt tataaataac ctgtattatt attatgcagg ttgattctgt tccctgagct 4380 aaagggaaca tgaaaataca tgtctgtgac tcatgccccc ccacccccac tccagggtgt 4440 gctgaggagt ctctcagctg ccccggggtc ctcgagcagg ggagggagaa aggctggcgc 4500 tgcgccctcc atcgcgtgaa gccaggggat tttgctctgc gacaagctga cttggctctc 4560 gtattgtttg cagaatcacc cagttccaag gcagtccctg cgggcaggtg cagctgtgcg 4620 ggagcttcag tcctgtcccc aacacccagg cagtaatggt tccagcacgg aaggtctacc 4680 tacctcccac tgcacagccc gagggctgtc ctggaggcac agccatccgt ccctgggtgg 4740 gcaggcacgt ttatgacccc cacccccacc cccacccccc acgcgagtca gcacgttcca 4800 tactcgggtg atcgtgctca tcccctggtc atgtcatcgg gatctgagtg ccatccgagc 4860 agagagctgt ggcccggtgc cgggggtgga cttcatctat tccagggaac caaggatgca 4920 tgatttgcaa acaaaaccag aagcgcaagc catctcctcg cctcccctga tagccgtgct 4980 gcggagcctg agtgctggag 5000 <210> 183 <211> 400 <212> DNA <213> Homo sapiens <400> 183 tgcgtttagt gtaaaaatat caggtgtggc tgcacggagt gaaaaatcac aggctccacg 60 gagccgggag gcctgctgcc ctgccctctt gctttgatga ggaaatggcg accgcagaag 120 gaaatgtagc agcaccggca accggcatcc gtggggccac gccgggctgc ttcccagggc 180 cctccagcca agcagccaca ggaaagagta gatgttgatc ccaagctagg actgaggagt 240 ccgtccctaa gagccgaggg agtcaggtgg gcgaaactgg ccgcatgtct gggtacaact 300 gctcagggtt tctcatctgc tgaatcacca agctaggttc tgaagccagg cgtgagtgag 360 caggactgga gcaggattct gggaacaatc ttttccctcc 400 <210> 184 <211> 293 <212> DNA <213> Homo sapiens <400> 184 aggtggaggt tgcagtgagc cctcctcccc tcctccccct tcccttccca cctcccatgc 60 ccccctttct tcctcccact cccctcccga ggccccgctt attctcccgg cctgtggcgg 120 ttcgtgcact cgctgagctc aggttctggt gaaggtgccc ggagccgggt cccgccttcg 180 gcctgagcta gagccgcgcg ggcggccggc ttcccccaaa ccctgtggga ggggcatccc 240 gaggaggcga ccccagagag tggggcgcgg acaccttccc tggggagggc cag 293 <210> 185 <211> 474 <212> DNA <213> Homo sapiens <400> 185 ccttccagat gttccagaag gagaaggcgg tgctggacga gctgggccga cgcacgggga 60 cccggctgca gcccctgacc cggggcctct tcggagggag ctgagggccg cgttccttct 120 gaaagcggga cgcgggaggg gtggaggctg cggggagccg gggtcgcaca cgaataaata 180 acgaatgaac gtacgagggg aacctcctct tatttccttc acgttgcatc gggtattttt 240 cgttattgta aataaaacgg ttccgagccg tggcatcgag agggcgtctg gagttcaggg 300 aacgcgtggc ccccgcccgg gagcaccgcg cagcgctcgc ctctcgccct tcaagggggt 360 ccctgcccgg agcctgcgcc cccggagagg aaggggctcg aggggcttgg gtgccgcagc 420 gcgtccttcc gtagaaaagg cttgcgtcag tatttcctgc ttttacctcc tgag 474 <210> 186 <211> 346 <212> DNA <213> Homo sapiens <400> 186 cagtatttcc tgcttttacc tcctgagtat tggaatattc gagtaaaccc tggagtttca 60 gcgccagcgc acgcctcttc atcagggcag cgcgtcgcga gcgcgctggt tccccggggc 120 ctcccggcca cggacaccgc tctagccagg gccacggcga ggccgccgag cagcacctca 180 gagacctgcg tgagttctaa agcctggggc tactacaatt ctgctcatct gtttgtcctg 240 tgaaatgatt cagggacatg aaaatgcctt cccactgact tgcgtcctgt cttagcctgg 300 acttgtcccc ttgggaacac gggccaggcc cctctgttcc tgaagt 346 <210> 187 <211> 2000 <212> DNA <213> Homo sapiens <400> 187 catacatggt tattagaaaa ggcatctcat ccaaatgtgg tggctcgtgc ttgtaatccc 60 agtgcttcag gaggccaagg gaggaggatt acttgagcct aagagtttga gaccagcctg 120 ggcaacacaa caagaccttg cctctacaaa aaacttaaaa actagctggg tatgatggtg 180 cacacctgta gtcccagcta cttgggaggc ggaggcgggc agatcgcctg aggtcaggag 240 ttcgagacca gcctggccaa catgatgaaa ccccgtctct actaaaaata caaaaattag 300 ccgagtgtgg tggtgcatgc ctgtaatccc agctactcag gaggctgagg caggagaatc 360 acttgaaccc gggaggcgga ggttgccatg agccgagatc acgtcactgc actccagcct 420 gggtgacaga gcacaaaaga caggcatgac tttgtactta actgctcagc tttgtaatca 480 ctgggggccc agatgctcac ttggattcta actttgttgg catctgggcc taaaagccgt 540 gatgcaggtg agcaatgatg cagagggctc tgtgcgcctg gcgggctctg tttgcctgct 600 gggctctgtg cgcctgctgg gctctgtgcg cccgggaagg tgcggccacc ctcacgcgga 660 aggcggccag cggatcccgg tgcgcgcagc tcccagcgct ggggttccag cgccccgcct 720 cttcctatag caaccagcgg gacctgccgt cccccggggc accccgaggg gtctgcgccc 780 gcttctttcc gaaacgggaa ggcgctgggg gctcggcagc cagagggacg ggttcaggga 840 gcgtccggtg agcctaagac gcgcctttgc cggggttgcc gggtgtctgc ctctcactta 900 ggtattagga accgtggcac aaatctgtag gttttcctct gggggtgggc ggaggctcca 960 aaccggacgg ttttctcctg gaggactgtg ttcagacaga tactggtttc cttatccgca 1020 ggtgtgcgcg gcgctcgcaa gtggtcagca taacgccggg cgaattcgga aagcccgtgc 1080 gtccgtggac gacccacttg gaaggagttg ggagaagtcc ttgttcccac gcgcggacgc 1140 ttccctccgt gtgtccttcg agccacaaaa agcccagacc ctaacccgct cctttctccc 1200 gccgcgtcca tgcagaactc cgccgttcct gggaggggaa gcccgcgagg cgtcgggaga 1260 ggcacgtcct ccgtgagcaa agagctcctc cgagcgcgcg gcggggacgc tgggccgaca 1320 ggggaccgcg ggggcagggc ggagaggacc cgccctcgag tcggcccagc cctaacactc 1380 aggaccgcct ccagccggag gtctgcgccc ttctgaggac cctgcctggg ggagcttatt 1440 gcggttcttt tgcaaatacc cgctgcgctt ggacggagga agcgcccacg cgtcgacccc 1500 ggaaacgaag gcctccctga tgggaacgca tgcgtccagg agcctttatt tactcttaat 1560 tctgcccgat gcttgtacgt gtgtgaaatg cttcagatgc ttttgggagc gaggtgttac 1620 ataaatcatg gaaatgcctc ctggtctcac cacacccagg gtgacagctg agatgcggct 1680 tctccagggt ggagcctcct cgttttccag agctgcttgt tgaagtcttc ccagggcccc 1740 tgacttgcac tggaaactgc tcaccttggc atcgggatgt ggagcaagaa atgcttttgt 1800 tttcattcat cctagtgttc ataaaatgga aaacaaataa ggacatacaa aaacattaat 1860 aaaataaatt aatggaacta gatttttcag aaagcacaac aaacacaaaa tccaagtatt 1920 gccatgtcag caacacattc ctactttaag ttttatgaag ttaattggag tagtggagaa 1980 caaaagtgga tgtggggcag 2000 <210> 188 <211> 149 <212> DNA <213> Homo sapiens <400> 188 gctggaccag aaagtgttga gtacctgctc atgcgtgcaa gaggaggagg gaggagcaca 60 tcactgaact tcacatgaaa ttggataccc gggattagag acagtagagg gttttggtga 120 aatcagatac acattgcaaa gcagcacac 149 <210> 189 <211> 146 <212> DNA <213> Homo sapiens <400> 189 ggtcgagttt ttggtggtgt tgagcggata gccggggaag ttggagtctt gtttgtggcc 60 gcctcgtgct cgtgtctgta tctaagatcc tcaggctgct cctttttggg taaggtctgt 120 tgcttctcta ggaacagtga cggtgg 146 <210> 190 <211> 133 <212> DNA <213> Homo sapiens <400> 190 cctcgtgctc gtgtctgtat ctaagatcct caggctgctc ctttttgggt aaggtctgtt 60 gcttctctag gaacagtgac ggtggcagag cccgtggccc ctctctcctg tcccagagcc 120 aagctgtttc ctc 133 <210> 191 <211> 95 <212> DNA <213> Homo sapiens <400> 191 ctgttgcatg agagcagagg ggagatagag agagcttaat tataggtacc cgcgtgcagc 60 taaaaggagg gccagagata gtagcgaggg ggacg 95 <210> 192 <211> 127 <212> DNA <213> Homo sapiens <400> 192 tgcaggatat ttggcaaggt ttcttactgt tccaagtttt ttttccgaaa acctcccttg 60 aaacttttgt gcttacttgt ggtaacatac ccataatata ccctcttaac catttctacc 120 ggcacag 127 <210> 193 <211> 104 <212> DNA <213> Homo sapiens <400> 193 tgaatcagtt caccgacagc cttggggaca ttcaccttgg gctccacaac ctgtcagaaa 60 tgcccccaag cccaaaggcg tcgagagaat ggccaggttg tttc 104 <210> 194 <211> 127 <212> DNA <213> Homo sapiens <400> 194 ccgttatatg gatgccttgg ggcttggggg gtttctggca gtctgtcgag cccgaggtga 60 atgtccccaa ggctgctggt gaatcagatc cctggcgttc tccgttggca gttcagccca 120 acagttt 127 <210> 195 <211> 144 <212> DNA <213> Homo sapiens <400> 195 ccaggcaaga tggcttatgt ctttaatctc agctgtttgg gaagccaagt ggaaagattg 60 cttgaggcca ggagttcaag accaacctgg ataatgtaag aagacctcgt ctctataaaa 120 aattaaaaat tggctgagca tggt 144 <210> 196 <211> 110 <212> DNA <213> Homo sapiens <400> 196 gacccagacg atacctggaa attatttgct catgtggcag tcactgttga ttgcctaccc 60 aaagccatta ctccttctcc ccacctaaca gaagccgagt tttgttcagc 110 <210> 197 <211> 101 <212> DNA <213> Homo sapiens <400> 197 ccacatcctg gccatctact tcctcttaaa caagaaactg gagcgctatt tgtcaggggt 60 aagtgcgacc ctagaggcga tcgtctctgc tgtctgtgga a 101 <210> 198 <211> 88 <212> DNA <213> Homo sapiens <400> 198 tgagctcaca ggtctggaaa tggtctgaat agaaaggatt ggtctccgga ggaaagcata 60 ctcttcctat taccagaacc ctgtgggg 88 <210> 199 <211> 128 <212> DNA <213> Homo sapiens <400> 199 attctccaca gggcaatgag gcaagaaatt tacagcttag cctgattaat gggccaggca 60 gttaagagtt ctttgccaag ctatgagcat aatttatagt catcacggca ggaggaaagg 120 ccacataa 128 <210> 200 <211> 836115 <212> DNA <213> Homo sapiens <220> <223> NC_000021.9_gene_539 [gene=DSCAM] , region 40010999..40847113 <400> 200 tgactgaggc cggagcacgg caaagatgag cctgcccgcc cgcctgctgc ctggatgcgg 60 agggtgaggg ctggcgcacg ggaggccgct ggctgcgcat tctgggcgcc gagtgcccgg 120 gatgagctca cgcccgcgtc tgcggctctc tccacctgcc gacctgccgg gggcccactg 180 agctgacggc gcacctgggc tccggccgca gcgtggggcg cggcgcccgg gagcaggtgt 240 gcaggagcgc agcgcgcggc gagcgcagcc ctcgctccgg agcccggccg cgccgcgtgc 300 ccgggcggct aggcagcggc ggcggcggcg gcgggcggcg ggcgggcggc ggcccccggg 360 caggtgccga gcggcgagcg gagccgggcc gggcggagcg cggggggcga ggccggcgcg 420 tcgctcgcgg gaggccgggg agcggcaggg gcatgtggat actggctctc tccttgttcc 480 agagcttcgc gaatggtgag cctttcggtt tgtgatgaat ttcgtttcct tatcattgac 540 cgggggggcg ggggggtggg gggtggcatt ggatgcatgg gtaaagtctt ctttcttttt 600 ccgcttcatc tgtgtttaaa atttcgtgct tttatttatt ttttaaatat catatttatt 660 ttttggggga gaagaggtgg caatggagag gcccgggaga aattgctctg taatcattgg 720 aaggcgctta cctagccaag tgacagctca gagcctaact ccagtactag agagctgcct 780 cattcagaat aaaccaggtt tggtgacaga aggagagaca ggaagattgc cactttgaat 840 attacaacct ggaaagggat gtgacattcc aagtgcacgc aagtggaggg gtcaatgagg 900 aacatctccc ttcagattca atgctttttg agatttttca aacacgtaat ttcatgctag 960 tacaatgtat ctccagcacc aaggagggct ttaagaatgt tctgtccttc tatgcacccc 1020 gtgctgcttc atgctcctca cagtcgttta tgtaaaaata tgcactgata agcattacat 1080 catctgaaat gttgacaaat taaaaaaaaa aaaacacctg tatagttgta aaaatgaaat 1140 cagtgaatat tgtaaatagc atacatttcc tcatgcccag ccaatattat attttgaaat 1200 gatttcttcc tgggtattta gaaagctatt gctcttgact gagtcagacc caattagtaa 1260 gtgtgactgc accttaggct gcctgtcacc gcataaatat gaacttacat gtatgaatgg 1320 cttcctctct tgtgggaacc agaggaaatt gtcatcattt gacatcgcct gggagtagct 1380 acggcttaaa ttcccatttc aaattttgga acacacatct gcataaaatg tataacctac 1440 tgacagttga aattaaacca ttaagcagaa tcccctagcc agaagagagg agagagagag 1500 agagaaagag aggagggaga gagagcgaga cagacacaga gacagagaga gagagagaga 1560 gagagagaga gaggagaaga agagaaggta aaagaagaga agagaggaaa tctggccctt 1620 gtgagaaaat acgagaagca aaggggaggc tctaagattt tcctggaaga cacacaggga 1680 agctctgtgt gttggctgca aggcagtgca ttttctttgc ctacctagac agtgcctaaa 1740 gaatcagcat accaacaggc cagaagaaat gcatgagcat tgtcaatttt ttaaaaaaac 1800 ggtgactaag aaaaggtaga gttgaaagaa ggtactatca aaatgaacat gaaaatgata 1860 ctttgctctc cagtataacc taaagcaaag tgtttgaaac tttcattttg agatttccta 1920 gcaggaaaga attgcaacaa gttctgacaa gacacccatc tttcccagag ggcaccatac 1980 ctgtcctgtg tcctcctggg aatttccctt cagggacaga tgtgcttagg gaacatgcgg 2040 agatgtgtcg gggaagtcag ccctttctgc tcttctgcta atgcgacctc ctaagaaatg 2100 tagagatgcc tacacatgtg ttccaaagac acagagcctt gacaccctgt ttcgcctgtc 2160 agggagtacc tttctgaact ccttggaaag gcctgggtta taagaagaaa caaaatttgc 2220 accccattgg gaagtgtgtg tttcaggatg atgaaagagg ctgtgctggt tgtcagtcag 2280 ccagtattta tttacagttt tagcattttg tatgacaaaa tggtatggaa gaatttatga 2340 tactgataca gactattagc ctctgataca gagatgctat atgtgtgtgt gacttttttt 2400 ctgaatcagc attttataac taaaataaac aatcatagaa ataattatat atggtaatac 2460 aattatatga aacctcaaat attctgcaat atgaaaaata tatgcaaaaa ttatgtaggt 2520 actcatatag tgagttctgc aagtattatt ttcaagactt ttaaaatcaa ctgataatca 2580 ccattattgt aataaatata ggtagattcc acaatattag acataaacag caaacacaaa 2640 tgaatatttt acattgctgt attacgtatt ctgatccaat ctagcagaag gctatggaac 2700 tgtcttgtat aaaaatgccc ctctctttat atgatcaagg atgaaaacat taaaagcctg 2760 ctgtaaagct ttaggatctt tgaagggggg aggggaaatc agctttaaac agttttctaa 2820 ggtatggtgt tcattacata ctggggaaag gatcataaaa tatatagaca tgttgaaata 2880 aaataagaat ccagtttgga actatgcctg tttgtaagac catatttcaa aaatataaga 2940 gtaaatggtt tctacctatc tgaattaaac tttaaaaaat tgagaatatt tttgtcaaca 3000 actgtcatat tttgttatac ctcaactttg aaaaatttct gaatgtgtgt gataaaagat 3060 tgatgaattc taatacctaa actgattatt gctaggcctc aagcatcaaa atgcctgaca 3120 tgataacttt tttttttcat ttgtaaaaga ttatgtagtt taatatttgg ggctattaaa 3180 ataagcccac aatacatctg cattttaaca gtagacaaca atatttttct tattgatgta 3240 tcagaagtac agttatttct taataaaagt atggttgcta gacaggctgc aggcagtatt 3300 tttgaaaaaa aaaaaaaaaa aaagaagaag tcagtgacca ggcccttcat aggttaaacc 3360 cttaaatgaa tgacctcacc tgatgaggtg cagtatcgtg ttttaaagca gtcaatttgt 3420 tctgcaatgt tctggaaata cacgcgagct tctgttacag tgcaaggagc caaggtacac 3480 gtatgtgcag acactcaccc acacacgtcc ctcggtgtct tctcagcaaa gcttcctact 3540 gcattgtgtt tcattaccat ttctcctggt tttaacccca gagcacattc tagtttaaaa 3600 ttattgctaa aagaagagcc aggccttcag acaaacagaa tgatgaagaa ttagatttat 3660 tatatgtaat atagttttgc tagtatcctg gcatctctgt ttttacacac acacacacac 3720 acacacacac acacacacac acacatgcat gcattcctga catcatcttt tcctgagctg 3780 tgggattttc agttctactg catccgcttt catggggcct gagggtcatg gagattagag 3840 acggtggggt gctgggagta agaaggtgct cattaaagag aagatgagta tgcagcacct 3900 ttgagcttca tccattcact tgataggaaa ttacagagca cacgcttgct attttattta 3960 attagaagca gacctttgta aatacaaatg caccttaagg acttcaaagg tgatttttat 4020 ttaattcaca taaatgtatg taaggaagaa atgttatcag gtgaacaatt tcagggctgc 4080 ctccacttcc ctttctcccc catctttatt aaacagatta aaaagctatc cataatctca 4140 gggttcacct aaattccgag gccttttaac ttaagctgca tgcccctcca agatgccctc 4200 tgtaggaaaa caaaatgcca cgcagacctt caataaatgc cagtggatcg ttctccactt 4260 tttgactctc tcctttgtca ttttggtgtg accacggttt gctgcctcgg gggatcagtg 4320 agtcacgggg ggcagaacca gcgcaataca gcattctggt aggggaacta attttgacta 4380 aaatatttgc caattctaat ccccaattcc tggacctccg ggtagctggc aaggtatttt 4440 atgttagatg tgtctggagt aaggtgcacg gagtatttcg acaagagact caattcaatg 4500 cgtattaaaa cttgattgag agagggagag agagaggtca ttttataaag aaagacctgt 4560 gaacactgta gattggaaat ttatgtttgc aaaataaaag gatgggttta tcaagtggat 4620 gcatttacaa aatgtggcat ccaggtttcg taaaattagc tgaattctac gggtaagatt 4680 atgaatgtgg ctcataaata attaataggt agtgaaaaag aatgtatttt gcattaggca 4740 gtgcattcaa tagtatttcg gaaatgagca cttcgatttc ctcggtttcc atgcgtggcc 4800 cacctctcca gagcagggca ggcacccagg ggtgtgccca cacaaacaag cgcgtgtggg 4860 cattttcttg gctgctgcgc tgaagtgcac gctgggcctt ggtgcccgca ccctcagcct 4920 gggagatagg gaggtggtgc tacctgcagg ccgattgtgt ccccgccata ggacactagt 4980 gggcggcaaa cctcacaaga ctcttgcagc cagccttcag cagagccagc aaacccagcc 5040 gccaccgagg gaggactgct ccatgcagat ggtcaggggc tttcttctga agacgcctcc 5100 cccacgatct ctcaagttca ctgcgcccaa actccggcgt cgtagagttc gtctaacagg 5160 aaccgggcaa aggcaaccgc aggtcaggcg aggtccagca gcctttgttt tcaactgtac 5220 agcggaggac cgtattcaca gcaatatcta gaaacctaga aggtgcccag aaaggaaaca 5280 caggtgttgc agcgggtagc gggcccgcag aagggtgcat ttgcaccccc tttccaaagc 5340 cgcgagggaa ccccggcgtg gcgcgcgcct cggaggtggc agctccggga gcagctccgc 5400 gcctgattgg ctgaccttcc aatgtcattc caggagccgc cgcttctcct gctgatggtg 5460 acaggggtga tgctgacgtg cccgctcctc cgcagtccat caatctccgc aggcaaggct 5520 ccgggaccgg gagccccctt ccctctcccc caggcccact ggaaaacacc tgttcccctg 5580 gactgggggg ttaactcttc aagttccaaa gacctgggca caaaaatgct catcttatct 5640 ctccgcgccc ctccccccaa ctatatttat gttcttttct tcaatgttgt gaaaatgcca 5700 gaaaattcaa agttgcattt cccttgccga atctatgggt taagataagg cagtgggaat 5760 ggaagattcc agcagcccca cggagtatcc actatgtcgt tctgaattca aagggtggag 5820 cacacggatg ttttctgcag gtgacgcaag gtctgtcaag gtggcaggag ggaagcaggg 5880 acaggatttt ggttcagagg tcagacagct tctgaccagg acgttcagaa gggttgggtt 5940 tcacaaatct gctcctgaaa atcagttccc tccatattat cctttttcta aaaatcttgg 6000 ctgtttcctt gatggagtct gtggtaatcg ttacgcctgc atttaggtga tgctgatttg 6060 gctagtgact gcctctctca ctagctagac aggagcctcc atagtctgaa atgcgtgcga 6120 agcctgagcg tgtccttagc acagagcaga gcacatggta tggagtagtg gaaatagatg 6180 atgttcctta cggagtgaaa ggaaaaagtg ataggcagag cctttctccc ctccttaact 6240 cctgtccacc ttcctccctc ccgtccacct ctctcttctg cctctagctg attggctccc 6300 cctcttagtt tgctttcctg gacttgctct cctggtccct atcttgcatt ctgactaaac 6360 cactggactc ttttgctcta cccacctttt tctgtcgtag tgactcaatc acggtagaaa 6420 tgtttatttt ccagaaacgc ctgtggcttg gggcattttc ttctcttttc aaaaagagat 6480 tcatatttcg agtatctgat gggacttcat cactgttgca caacagctat gtaattgctt 6540 taggtgctct tcctgccgtg cagtgggtca agtgtcacag acaataattt catccatgtg 6600 ctggacccct tgttctcaag tgtacgctgc taaatggcat gatttaaaat tcctatacag 6660 tgtttattgc cctgtcgcat tttgaaagcc agccagaaac atcaaaccga catttaggtt 6720 ccccgcccac tccgccaccc ccagctcttg ggaattcatt tcttcatcaa agagccaccc 6780 aggacatcaa aacaaagctt actttctcag gccttaattc atctttaaaa agtcatacta 6840 ctgttttctt cagcatccta tggatttatg ggttttttgt cattatcttt atttcttatt 6900 ttgcagattc aaatatgaca gttgctatct tcatcaaagt aacatgaaag gatatcttaa 6960 tcattgttaa agttgatttt tgtccaaata taaaaatcaa attaagtgtc ttatagctta 7020 caatatttat cagcttttga tttttggaca tctctatttg ttctatgtga tcaacgctga 7080 ttttttaaaa atcatgcaac tggattaatt tttgatcttg aagccccctg gattatgtaa 7140 atacatatta tggtttaaca gagagggatg aatgggattg agaagatata tgtcaagata 7200 tgaagaagga aagaggctac tacacagaga gttagaatga cagggattaa tgaatcttgc 7260 ctgtatccct agttattttt tttactgaga agacagtgag taagatttaa gagtgagcaa 7320 gcagtcctat ttatagaaag ctgtttttaa gtgcagccgc aaagacagtg aaagaaagaa 7380 ttgaaaatgc aagagatcac ctccatacta aatgctagct tcccctaacg tcccagctct 7440 gtacagcatt ttgtaggaga aaaaaacaaa aaaaaaagca taccaaccct tgcagaaata 7500 ttatgaaatc tctttggact ctctgcagaa tattctagaa gtgctctcag tctttaagtc 7560 tatgttaggc ttgggaagct ggggatgaga aggcaatata tatattatct ggaaacagct 7620 tgagtaggtc tgaacaaaag actggaggtg aagggaggac attgaacttg cagcactgct 7680 acaaatattt attctgcaat aagccttgcc tttcttaaag atgtttcacg gcagaatagt 7740 aggagggtga aatctgcata catctcagta ataaagcaat tactgagaga agagttcaaa 7800 tttaggatcc tgtgattatc acaagtccct ccatgttaac ctgttctcaa actctggggt 7860 tttaaattgc aatatatgaa gtccttattt gtcagtctgt gtcgggcaga caatatcacc 7920 ccaggctttg tgattgacac aaatgttatt ggacaaggga aaaagaatgc cacatgctct 7980 tataaatgaa atagtcttta taagattcca tatataagtg agatcatgga ttttgtatgt 8040 gtgtgtctgg catatatcac ttagctaatg tcccccaggt tccttaagta tatacaattt 8100 agcataaaaa aagaaatgaa atagttttcc tttctaggcc tgtatttgtt acttatagca 8160 ttctggtttt cctggttcca agtgggcttt gggttttatt aatagtagaa tcgttgaatt 8220 tttatgcaaa tactgctgat ttacaggttg gaaatctgga caaaatcaga cctgccctag 8280 aagatgatgc tgtggaaagt gtttgccttt tgtcttataa agaaccatct ataaaatgga 8340 tcattttgtc gctagtctct ccagactatg aaattggcat tttgataagg tgatggaaag 8400 aaatttgaac tatttaatta ctgattttga ttcatacaag ccttgactct tttagtatta 8460 aaatgaagaa acaggaaaca gttttaagtc tggttttaca taaaatttac acttttttca 8520 cactgaaaat aaaacagtaa aagccagctt atagttcttt ctaaatatcc caactttctc 8580 attattggat gcttctgcaa aacagcagta tggtgatacc actcccagtg ttgaccttga 8640 tgacctgagg gtcccaaagt ggcttcagca ttatcatgga gtcaccacaa tgatcaggta 8700 gaagctggtg ttaggaccag cgtgaatggg tcacaggggc tgaggggggc tgttgggagg 8760 tagcccatgc cgtatactga agagccatcc atgccacttc aggtgggtga ttgcagtgga 8820 ctctcttacc attgattaat cttcctaata ttgagtaaag cattgattct tctcataagc 8880 atgaactgct ggatgatggg aacatttctg tgattgtatc ataagagaaa gacaagtaga 8940 aagataatta gaactgctgc aattctatgt atattttaat ttaatttatt tttttaaata 9000 caaaagacag ctatatttcc tatataataa ggaaacttat tactttaagg aaatatactt 9060 tctcacgaga gaaactcaag attcaattct tttcacagtt agccccgctg tggtgtgatt 9120 tgatcttggg ttccatagag atacagaaaa tccaagtccc agtctgctta attgccatgt 9180 ttatttttta atctcggctg tagagcattt ttaataactg atatgtagct tgcagggtag 9240 aaataacaat gctttggaat attacctgtg agactttagg aatgagctga agacacccaa 9300 caatgacaac aatggcctct accagcaaaa cgggaaccat gactacttta tcactcctgc 9360 cggatctagt tcttgtcagt tcctgcaaag gctagtcact tgtctatttc gttggctagt 9420 gaaaaggaaa tgcacaagaa atgtggaatg ctgtctaaca gacagaatcc tcctttcaca 9480 agttgtttaa gttggcagcc caagttagca acctctatcc gggtccttaa cgtgacagca 9540 gaatgtgggt aggatggtta attaccagat gtgtctgtta tgactcaccc aaatcaatag 9600 ctattaaatc cttggtggct actgttttag aataggcttc attgaatatt tgtatagaaa 9660 tctgggtaga aaaatgtgga cctcgaggtg atctaggtat ttgttttggg caaggaactc 9720 tcatcagtgg ttggtttatt tgtgtcttgg gggatctcac atcatcagcc tttattaatc 9780 acaggcacga ggggccccac actctccccc atacctctac cgccccattg ctgaggatgg 9840 gagagtaaga atatagaata tgctgtaggc ttctgtggga ttagatgctt ggaggcagcg 9900 gaggcaaatg ttcatgggaa cactgaatat ggaggaagag gctgtgccag ccccatagcc 9960 acacatcccc tccaccctta catcaggata agaggtagac cacagtctgt tgacacttca 10020 agctgaacat tagttagtat ccttctatgt gggccttccc aggtaaggat cgaggacact 10080 ggttctcaac accccggtgt tctgggtcag ggagaacaga gaaaggagat atggaagttt 10140 cctgaaatgc atttcctctc attagcctcc tgttggaaat tctgatgcca gcgttgtggg 10200 gaatgggctg tagtttggaa agctccccag gtgtttctaa tcccatgtga ctttgtcttg 10260 tttttcccac caccactggg gtctcccaag ttatggtttc catgtttgtt atgtcgtctt 10320 ccagctctga taccagagag tctgattctg tagccttggt gtatgcacga cctgtgaatt 10380 tgcattatta acgcatgcct ttgcctgttc tgatccacat gaaccataat tcacctttgc 10440 aaaacacaca cttgcaaaga agctacccaa acagtagcta ggaagttgat ccagtaaagt 10500 tccaagtaca tctcgatgaa ctgttggaga actctgtatt gggtagtaat ttattgggaa 10560 tgtctgtata cagggttagg tcttcactga ccaccataag aatttgggca tctttcggga 10620 taattggtgc tggggtttag taacaagaaa gattctgagt agaggggtat gtagatcctg 10680 ccagaggcac tcccaatgtg gatgctagca gcttacgaat catctgtgtg tattaatatc 10740 tatctctttg caccattttt tcttcctgtt agcgtatttg atattcaggt ttataaatgc 10800 ttgtgctttg cttatggtct tgattccatt gtatttctca cattggtccc ttcttcgata 10860 gcagctggag tcccagcaga gaagcccttt gaaacctgcc tgtaaccatg aagctccagg 10920 caagagatcc atagtgggaa accatttggg taactctact gaacaagctt aagagatgag 10980 ctagaacggg ctgagacagg gcaggagagt ggatctgttt gcagctagag gttttgcttt 11040 gatgccgcct tgggatgctg cacattcctt tgtccagggc acaagctcat tccagagcca 11100 gatctgaagg gctttgggtc atttgctctg ttggatgttc ttggctttct tttaggtaaa 11160 taatcacaag ttgactgtat ttaccataca aagtatatgt cattatccta agttgtcaga 11220 aaaaagagag aagctggcat ataagggcat atgtgcattt taaaccttgt tacatatatg 11280 acaaaataga gggcagttat tggtggcaga ttaatttttt caaaacatcg tgtccttgat 11340 tttggcacta aaatagactc aaatgtgtgc tggagagagg cctaaattca gaaccttaaa 11400 aatacctttt tgtgtcctga gatcttattt tagataatat taaaaataac tttccctcct 11460 aggcatctta aacaagtttg atgttataat cctttggtga ttttattgtg attcactata 11520 gaaattacct ttttgagtgg ccgttttgaa atttagcttt agaaggaaat ggtataaaag 11580 ccattgtagg ctgaataaat gtgaattctg cttactcatc actacaggaa ttagggtaga 11640 ctgtctcttt acaataatag tttcctatac tcatgttcct ttaaaagggg gtgggggcat 11700 tatattaaga agtcacaagc tctgacaggg gaattgcaga agaagatttc agtttaaaat 11760 agctcacagt tcctctctga tttggagttt tcacaaccta catggtatag cacagactgt 11820 tctcttttaa attttgtagt agagtaggtc aatcttttcc catctttctg ccacggaaag 11880 ggcataaata tttccatcat cagatttaat aacctgtgtt agactcatga gtaattgtaa 11940 atggtgaaac actttcttca taaaaaaaat aaaaatgaga gataatgtga ctcagtatta 12000 ttattagaac aaatcacctt aacccataga aaatatttct ttcctgcagc aataagtgtt 12060 gagtattttt ccctggggtc tctagcatct cttgataaga gtgaatattg ttaggtccag 12120 cctgactggt ggccaaggca ggttaagttt atgcaatgag tcgattgtgg tggagataca 12180 tttgcaagaa atggaggagc agtcggcatt tcacctctct ccatcttgtt cacctttctc 12240 tctccctctt tagaaactgg gagcaaatat tagagcttac atgtgctcag tgagagtgga 12300 gggagaaagc tgtattttcc tggggggtct ggaggccttc tctgggttta ttcattttca 12360 aagtcactgg tggtttgctc tctcctgggt aggtggaaga cattgctgtg acctcttgcc 12420 tgctcagggc acactgaagt ctagaagcaa gggttggagt tctctgagcc tgtgagtgtc 12480 cctattcaaa ggtgctcctg gaagtgtctc cctaaaggtc tttgatggag gaggctggta 12540 tttaattatt tttttctgaa gtgcacaggc ataggcatta tgggttattg taaagctcta 12600 aatagagcca tgagaaataa ggtaaatcca tggaactggg caactattat tattattatt 12660 attattatta ttattattat tattatttta ttattattat tattttggag acagagtctc 12720 actctgtcgc ccaggctgga gtgcagtggc gtgatctctg ctcactgcaa gctcagcctc 12780 ccgggttcat gccgttctcc tgcctcagcc tggcgagtag ctgggactac aggcacccgc 12840 caccatgccc ggctaatttt tgtattttta gtagagacgg ggtttcacca tgttagccag 12900 gatggtcttg atctcctgac ctcgtgatcc gcccgcctcg gcctcccaaa ctgggcaact 12960 attattttag gctcattatt ttttggcaaa tggaaataaa aagactcctc ccctattttt 13020 atgacttggt tacttttaaa agaagtatgc accggacaag ctgtgttctt cagtggttct 13080 taacggaggg caattttgca cccacagagg acagtgagca atgtctggag acatttttgg 13140 ttgtcacaca tctggttggg ggttgctact ggcatctgga ggggacactc actataagat 13200 gctcaacacc ctgtaatgca caggacagct ccccacgaca aagaatgatc cagttcaaca 13260 tcttcattgt gccaaggttg agaacacaga cttaaatagc tcagagtcta gttaccgtaa 13320 catcagtact gcgttttttc catggatttt agagtggtcc tggagagaga ggaggaagga 13380 aaatgtcatg aatctcagtt gcaattcctt tggctgctaa aaccatagct ggtgatgctt 13440 gtcattgatt aactttattt gctattttct ttcttttctt atgaagaaag ggaagccaaa 13500 tctgtgttcc ctcttttgtc attaagaaca tggatgctca gggtgttcct gggttcctcc 13560 agccatttct ccctcaagca attatgctaa ttagtgtttg atcagatgat taaattataa 13620 tgtgattaat cctgtgtgct aaccgctctg aatgcatttt ctctcgcctg gttgccctgt 13680 gcctgaagca cccttttctg cggctggcgg aggcctgttt ttcctgtgga tgtggatttc 13740 tgttttcaaa gcactgcaaa ttctctttgt tgcctggtaa aagggagagg ggatattttt 13800 gtaacctgtt ctctcaggca aaggctggac tggagagacc tctgggaaat attgaaaccg 13860 tagctagaaa gcactaatga tttgaagata ctagatgtgg agaaacgctt gaagaggaga 13920 gtgcagagac agctgtagtg gctccaaagt ccatgaaatc tttttctctg agagactttt 13980 cgctgtttgc cttcctttcc cttctgagtg ttgcctaagt ctctgcctct tgtgtatgtg 14040 atggccccgg gaggggtgtt ctcggtttat tttaggttta tatttcctta aaaaggcacg 14100 acatcatctg gttttgtttt ctgataacac agtttaggtt tgctcttgca tgccgtgtac 14160 tttagactgg gtgatttttt gaggtgaggt tcgttaactt aaaatgttga tgaaatgctt 14220 cctaatgtaa gaaaattggg actgcatagg aaagaatgtg agtagaaaat atcgatggtg 14280 gtgttgtcat tgatgggctt cttctctaag gctgcagatt accatggctc attgtgtagt 14340 ttgatgagct tagcagtgat tgaatttttc cttgcaccct atcacttttt ctccctttat 14400 attagcttaa tggggtagtc tggatacaag aaataagagc atgtagaata tgtgcagttt 14460 tttaaatcag aatttgcctg tgttttgatc tggctggaaa cgatagcctc ttgcgttcaa 14520 gagcaggtca cacgatgata ccatatatta ccattccagc ttcccgcatc ctaagaaccc 14580 ctgggccaca agaattactc atagagagag taattatctg catagattgt cacatacccc 14640 ttcgaatatt gtgtaatctc cttcatagaa atgaaaatct cttggtttgc tttgaagaaa 14700 gatatcctcc ttgtaattat ttccctaaaa aagaatgagg gtaaaaggaa actcgtatgt 14760 attgggcatc taaagtgtgt ggacacttga gtgaccattt gattcgcact cgttatgttt 14820 attagctaca atagtaatga tcataaaaac aatagcttga atttatgatt tattactaga 14880 tgtgaatatt gttattatga ccatcgtaaa gaaggcatgg ttagacaatg tgctcatggt 14940 cacacaattg ttgaatgaca gactgaggac tacgcctctg ttcattctca gtcaaatggg 15000 tatttttaat ttcagtttta cagattgcaa aaccagggtt tggaaatgtt gactatcagg 15060 ccctggtcag gtggcaactg tgatttgaga atagcacttt gagcccaggt tgtctggtgt 15120 cacagtcttt aaatcttctc ccaaatcaag ccacattcat tcatttgaag ttttcaagct 15180 gaaaatgatt atgttaaatt ttctttaaag agttgttttg ggaaagtgaa agatcggttt 15240 ttaaaaatcg gtgtataaat ggaaaattca tttacttttc catgtcagcc atttcgctta 15300 cttaagttag ataagtaaga gacaggttaa ttaactctta cccacttcag aggtgcaact 15360 atttcatgag attgcattct gttgggaaga gtaaaattgg agaccagatg acagttatat 15420 tacattcata ttacaggata gaatctttcc ccaactctca aatttaaatc atgcatctgt 15480 ttttaagtac actctatttc atttgtcctg aactgactac caattttctc aatgccaaaa 15540 tatcagaatc aaaatatttt tgaaattgct aattggaggc tgaaattgtg agttttgtat 15600 cagtttgagc ttttctgaaa aaacacccaa attagttttg ttagtaagcg tctgaatctt 15660 attgaagctg aatcatttta ccggaagtgt ccatgggaca tgcgtcttaa agagtttaga 15720 aaatactgcc tagacatttc agcctgactg aaagctcttg taataaataa gaataagcta 15780 tgcctgtgtg tgcctgtgtg tgtgtgcata cctgtgccac gctatggtga tattcttatt 15840 actctctcac actgagttaa ggttcaagcc agctactcat atgtgatata tgtcttctga 15900 gaaaggacat ttgccttctg tggagtgtgt ccattgtcca aatgtgatga aaatagacca 15960 gttctctcag agctcagagc ttccctcggc tgctggctgc aaggtggtgg aactcggttt 16020 attgcctggt tggcccctct gcaggataca cactgcgtgg tgctggttgg aatactgttc 16080 taatgaagtc accatctggg tccactggtt ggtcccctgt cgtgacaatt gccttcatcc 16140 tgtccaatca gccacctcac aaaccttggc cagggatccc atggagagtc tgactacaga 16200 gaaatttaaa gatatttgtc ttcttgtctg tggcctaagc agcctgaatt tcatactatg 16260 gtaatactga cagaatcacc tgtttatgga gtggtgaatg aacctgttta tagtaattgc 16320 taatattcat tgagctctta ttgtgtgcca gaaactgtgc taagtgcttt tttctaccat 16380 cccatttaat tgacaaacaa gtctttgagg tgcctgttgg tattatttcc actttacact 16440 tgcggaaatt caagacttac aaaggtgaat gcctttccta gagaaggcat acattgagcc 16500 ggggtggaag caggatttga acccgggcag tctaattcca gaactcctgc acttgacttc 16560 caggctgtct tcctggatga atgagcccca gataggtcag ctggtttctg agtgcacata 16620 ctatttagag tggtgatata gcttggatat ttttccctgc ccaaatctca tgtccagttg 16680 taattcccag tgctggaggt ggggcctggt gggagacgtt tggatcacgg cttggcgcca 16740 tccattagga gggatccttc atggcgtggc gctgtgcttc atgataggga gttctcttaa 16800 gatctggtca tctaaaagtg tgtggcacct cccccaccta ctccctgtct ctcttgttcc 16860 tgctttcacc ctatgacctg cctactcccc tctcaccttc cttcatgagt gtaagcttct 16920 tgaggctttc ttagaagctg agtagatgcc agcaccaggc ttcctgtaaa gcctgcagaa 16980 ctgtgagcca atgaaaccgc ctttctttat aaattaccca gtctctggta tttctttata 17040 gcaatgcaag aatgacctaa cacaaatggc catgcttatc tggaaaactg gaaatgtaag 17100 ttatggggag agttaagagg agccagatag caaacatggc tttcttaagc ttttctgaag 17160 gaagatgtgg gaaaaaatgt ggcaatatga gaacaatttg ggagtctcag ggttggtttg 17220 ttttcatccc agcatttctg gaatctcagc tcattcctga gatgagaggc tcagtcacga 17280 aaacattgcc aagcacttgt ggcctctccc atgcaactaa gcacctggtc atccccactt 17340 cccaacgtgc agcatgtgtc acccatcttt tcatatccat ttctatggta tttggattaa 17400 aaattaaacc ctccaaattt cagcagacaa cactaggtga ccaccacctg tctgtagtga 17460 tctcgatacc atcacggatc tatctcttga cagctgactc caacgccaac ttgcttttcc 17520 tctgacctgt ttcaccaggt gctcacacct actcacccat gtctcagaga ctatagactt 17580 tgtgatatac ctgattatac agccccagcc tatctgccat tgcatcagag cagctgcact 17640 tgaccaagga gctctcgctg cacacactgt gctctgactg gtctcattat gcatgaccac 17700 aaacctcgag tgggctctta gctctgccct caatctacct cactgcccta gttgatttct 17760 gtgtctgtgg gaagactact tcacaccttt ctcacctccc caaacctcaa actccccttc 17820 ctttcccaga ctctgagtcg ataacctcat atgatttact gagaaaaccg aagaatcaag 17880 tgaatacttg gactattccc tgctctccaa tacacaccca cacactcaat ttttcatgtg 17940 atcagcgtcc actcctgttt ttattgcctc cctttcaccc cactgatgat gggggattca 18000 gttatagggg tggttgaaca catgaccctg ggcagataaa attgacagca gtgttgcatt 18060 caagtattcc cacagcccag gggagtagga cagggcaggc catacagagt gaactagcag 18120 gggctgcggg aagcagacct tgtagtaaca agaagggatg gtggccgtgt gtgcacacct 18180 gtaatcccag cacttcagga ggccgaggcg ggtggatcac ctgaggtcag gagtttgaga 18240 ccagcctggc caacatggtg aaaccccatc tatactaaaa aactacaaaa attagctagg 18300 tgtggtggca tgtgcctgta gtcccagcta cttgggaggc tgaggctgga gaatcacttg 18360 agctcagaag gcggaggttg cagtgagctg agattgtgcc actgcacccc agcctgggtg 18420 acagagtgag actgtctcaa aaaaaaaaaa aaaaagaggg tggggtgtcc cctggttcct 18480 gagggaggat gtgattggct tatttggctg attccacagg ctgacgggag accgaagccc 18540 actactcatg ggtaagcagg cactgtgcct ggtccctatg agcggagtgc catttggcta 18600 ggggacttta tccatgacag ctcatgggtg ggggagaact agcaggtaag ccctttgagg 18660 ctcttctgaa tttatcccgt tcacagcaac acaatatgga accttaatct caggtcccac 18720 accagaccca tacacatgac cttcgctact gtgaccatgg aagccctggc cttgctcctg 18780 ttgaaagctg aaacctccat tcatgtccag aattccacat ctcccatctg cttaaagact 18840 ttgcccttgt atttattttt atttatttat ttttatagaa acagggtctc actatgttgc 18900 ctgggctggt cttgaactcc tgggctcaaa cagtcccccc gcctcagcct cccaaagtgc 18960 tgcaaataca ggtgtgagcc actgcatcag tcctgccctt gcattttatc tcagcctcaa 19020 cttccccctc ttccagctca gcatatcaac attctgtttt ctctctgtta tccctaccac 19080 tgtaaaacgt actaacaacc accacctccc atcttgtcac cacttccttc ttccatccaa 19140 ttcctctgat actttttaat agtaaaacta ctggaaagaa ttgagtatac tagtgcttct 19200 caaactaact gtgctgaaag atcagttttt cattttccaa tctgttgcag cttgatgtga 19260 ggtccttaca gtacttgcct caaacacagc ttgttgctca tgcttcttat cacatgagtt 19320 gaacgataca caaagttgcc tgtaccgccc ttcctgagaa tggagcccac tgatcacccc 19380 cttgaatgtt gcagcaactt ctcagtttct gtgcttgtct cactgtagac aagaaacaag 19440 cagctggtct gtacacactt cgattagcgc tgtttcaact cacctgacac tctcatcttt 19500 cagtctctgt tgaacacaca ctgatcaggt cttcttcacc actccattga atctgctttt 19560 gtcaatgagg ctgatgactt ccacatttct agtcttcttt ttctgtttat tttctttctt 19620 tcttttcttt tttttttttt tttttgagac atggactgac tctgtggcct aggctggcat 19680 gcagtggcac aatcacagtt caccatggcc tcaaactcct gggctcgagt gatcctccca 19740 cctcagcctc ctgagtagct ggactacagg tgctgcacca ccacgtccag ctaattttta 19800 atttttttgc agagatgggg gtctctttat gtgctaagat tgcaggcatg agccaccaca 19860 catgggccac gtttctagat ttcctcatgt tcactctctc agcagctgtg acacaacaga 19920 tcacacttcc cttcctgaaa caccttcacc tggaccgtgc acacctcact ctctgggttt 19980 ccctctgcct cactggcttc tccttctcag tgtctttggt gagcttcttc cctctaatta 20040 gactctaaat gttgcagccc actccaggga ttaattctta cccctctctt ctcctctcct 20100 ttcctctctg cttcctttcc cttcccttcc tctctctaat tcctctctat ataatttaat 20160 ttaggtcaag gcattaaatg ccctctctat gctgatgact tccatattcg tatctctatc 20220 catgatttct tctctgagct caaatccaga tcctgaaatc cagctgccta ctcaacatcc 20280 ctttacaaaa ctcacaggta tctcaacatt taaactctct gaaggaggcc ttctggattt 20340 tcctccctgt aaccacttct atctcacatt ttggtcattc aaactgagca tcgctcgtcc 20400 ctcactgcac agaacagaaa tctcagagtc gtccttgatt cctctctgtc cttcacatct 20460 tgtattcaaa ccaccagcat gtcctagtga tgctacttta agaatctgac catttcttct 20520 acctttaaat tccttcaagc tgcgttctcc tttttgcctg gactatcatg ataatctgcc 20580 aactcacagc tgaatttcca cccagtagcc aagggatttc ctcaaaatat aaagcagatt 20640 acatcactcc tctttccaaa gcctctccct tcatccccaa aataaacaca gcattgccta 20700 cacctcaaac cccttccatg gcctggcttg ggctggccca ccccaccccc tccacagagc 20760 catgctggcc acctggatgt ttctacagct tgctgagctg gtcctctcct cagcactgca 20820 ctggccgcgt gttctgcctg gaatgctcta ccctggcctt ttcccgcccc acttcttcac 20880 ttctttcagt tctctgtcca aatatcacca cctaagagag gtctccctga ccacctgatc 20940 taaaacaaag tggcctcctt gattgttcag tttctccttg ccatgcttca ggtttctttg 21000 tggaagtcag agtacttaaa atcatatact tagaagttta tcatctgtct ctcccaactg 21060 gggaagccca catttgtcta ctgtgctcac ctagaagagt gactaacagg ctgcaggtgc 21120 ccagtaagta gttactgatt gaataattaa accaatgaat gttgtttaaa gcaatgtata 21180 gctcttaggg actggatgtc attgctgtct cttcagttct actttattta tttatatttc 21240 tgatggaatg acagtatatc tctgtgtgac aatagtttct gcatttggaa gatctgcact 21300 tgtattttaa ttaaaagatc aacaagcatt atgccctaga attctcaact ctcacgcacc 21360 cataaaagat ataacaataa aaccccttac ttaaaaaaaa aatctttgtt gactacccat 21420 gtaatttctg atatgttgta tatactttga ggaatacaaa gatatttggt tcaaaaattt 21480 ttgaaaatgt ttactgaggc caggcacggt ggctcatgcc tgtaacccag cattttggga 21540 ggctgaggtg ggcagattgc ctaaggtggg gagttcaaga ccagcctggc cagcatggtg 21600 aaaccccgtc tctactaaaa atacaaaaat tagccgggcg tggtggtaag tgcctgtaat 21660 tccagctact cgggaagctg aggcaggaga atcacttgaa cccgggaggc agaggttgca 21720 gtgagctgag atcgtgccat tgcactccag cctgggcaac agagcgagac tccatctcag 21780 aaagaaagga agaaaaaaag gaaggaagga aggaaggaag gaaggaagga aggaaggaag 21840 gaaggaaaga aagaaaatgt tcactgaaca cctatatgca ctaaactgta acatccaaga 21900 aagcagggat tttgtgttgc ccattgtagt atcttcagtt cttagaacaa ggactgacac 21960 gtaagttgct ccctccatat ttgttgaata aataaatgag aaaaaaacac tatattaacg 22020 actgtgcaag aaacaaaaca acttcctctt ttctgggtca tggcaaagtc tccaggacaa 22080 taggacatgc tcacagcttc taaaagggtg tacccaataa tgaccaccat gtcggacata 22140 cagagaaagc tctgcagtgt ttatggaagc agaaaacaac ttctgattag cctatttaaa 22200 aagggcttca aagagagggg gatttaaaaa ctttactttt aaggttgtgt atgcttttga 22260 ctgggaaacg tgggcagtga aaagattggc aggagaaaag aggaaaatga gggaagtccc 22320 cgggtgtgga gggagagaca cagaattcta tcaagctgct gtgcaaagtc atggtggaag 22380 acacatctaa aaatgggata ggggccgggc gaggtggtgc ctgtaatccc agcactttga 22440 cggggccaag gcaggaagat tgcttgagcc caggagtttg aaaccagcct ggaaaacgtg 22500 gtgagaccca atctctacaa aaatattttt taaaaagtaa gctggggatg gtggcctgcg 22560 cttgtggtcc cagctactga ggaggctgag gtgggagaat tgcttgagcc tggaaggttg 22620 aggttgcaga aaaccatgtt tgtgccactg cactccagcc tgggtgacag aagtgaggcc 22680 agcttctgtc tccaaaaaaa aaaaaaaaaa tcaataataa aaatgggata gggagcagat 22740 tgtggaaaga tttgaattca aatttagatg gaattgaatt gaagattcgt gtgttaaaat 22800 gctcatctct atttgagcaa tcaatgcagt attttggttg ccgcacataa gagacattgg 22860 agagcagaga gaattggtgg aagggtggcc aagcaaaggc taattccacg gtgccggggt 22920 gagatgatct gccactagga cagtgatggc ggctgggtac tgacctaggt gggaggctgg 22980 gggacagagg gagcccaatg gggatgatcc aagcatgact gctgataagg ttgggtctag 23040 attatcccca tggcggtgtc tcacaatgtg agtttaccgt taaactaaag ctgtggatag 23100 attttatagc cttgtgtgtt taattactgc caatattgcc tacttttttt ttttcttttg 23160 agactctgtg aaatttgcgt ttctgcaaac tatgtgccag aatggagtca ttgacaggga 23220 ttttataaca cctgatgaga attattctat aattttatca cagcataacc caagagatgc 23280 tgaaacctga ctgcattgca atatgtatgg atcagagggc acatcctgaa gggctaatca 23340 gcttcaatca actcataact gacaagttta atttcttctg ttttttgtat ttctcttgaa 23400 attaaagtat acaaaaatgt agtattgaca gtgaatttgg gtgaggtttc actgtagcaa 23460 tcaccatcta ttattttaca aatcattggg atcaattttg gttcctgtta gcataaagct 23520 atttgggttt ttagtaacca gaaaatgaag ggttaagcac acctataaat atttatattt 23580 tttgttatgt agtataactt ggtatcaccc aaatatccat tttccctcat tcatatcctg 23640 aaaaatttta agtttaaaaa tgtgttccac gttgtgagtt ttgaaagcct taaacaagtt 23700 gaattgagat ttacaggatt caacttagtg taactttgac ctcaaaataa tttacaattc 23760 atttcatatt tcacatctgc agcctcactt tttcgttgag cagcttaatg gttttttttt 23820 atggtttatc tgtttttggc ctccttgtct gtcttccttt ctctcctcat cttgcacact 23880 tattgacaca cacacacaca cacacacaca atgtatgtat gctaagatta agcattcttt 23940 cttttttggg ggggcggtgc tggggggctg gtgtctcgct ttgtcaccct ggctggagtg 24000 cagtggcaca atttcggctc acggcaactt ctgcctcccg ggttcaagca attctcctgt 24060 ctcagcctcc caagccgctg gaattacaag catgaaccac caagcccggc taatttttgt 24120 atttttagta gagacggggt ttcgccatgt gggtcaagct ggtctccaac tcttgacctc 24180 aagtgatccg cccgcctcgg cctcccaaag tgctgagatt gcaggcatga gccactgagc 24240 caggccgaag tgttatttct tataagaagt ttatgtgtaa attctttgct tttgtactta 24300 ttgaaaaagt tatagttttg tacttattga aaaactgaaa ataaagagaa gtagggttta 24360 catattgtat atacccatct caacgtgata cagattgtga ggaactggca ctatctaagc 24420 agggtgatca tgatacagaa tgttactaat gttattaatg accgaagatg aaaccagtgt 24480 aaactcacca atgggctttc ttagaaggag agcattcatt aacctgaaaa tatttactgt 24540 gcttatttta tgtccattgg gaatatggaa taagataagc acagtataaa tatggtttct 24600 tagttggcca tttcattagg aaattatgac atagataagt acaaagtaac aaagtctttt 24660 tttttaaaaa aaaacagagg taatataagc taataaaaca aggagacaaa ctgaataatc 24720 caatttagtt agattataaa atgagctcct gatcattcta aaaagacttt tttttttttt 24780 tttttttttt tttttgagaa aagatctcac tctgtcaccc aggctggagt gcagtggtgc 24840 aatcttggct cgctgcaacc cctgcttccc gggttcaagt gattctccca cctcagcctc 24900 ccgagtagct gggactacag gcatgttcta ccatgcccag ctaatttttg tacttttagt 24960 agagacgggg tttcaccatg ttggccaggc tggtctcaaa ctcccgacct caagtgatct 25020 gcctgcctca gcctcccaaa gtgctgggat tacaggcatg agccactgtg cccggtcttt 25080 tttttttttt ttaactttta ttttaagttc ggggatacat gcgcagattt gttacatgga 25140 taaacttgtg tcatggaggt ttgttgtaca gattatttca tcatccaggt attaagccta 25200 gtacacgtta gttatttttc ctgatcctct ccctcctccc actttccacc cttcaatagg 25260 ccccagtgtg tgttgttcct ctctatgtgc ccatgtgttc tcatcattta gctcccattt 25320 ataagtgatg acacgtagta ggtatttggt tttctgttcc tgcactagtt tgctaaggat 25380 aatggcctcc agctccaaag acatggaacc aacctaaatg cccaccaata atagacaaga 25440 taaagaaaaa tgtggtatat atataccacg gaatactatg cagccataaa aaggaacaag 25500 atcatatcct tttcagggac atggatgcag ctaaaaatgt taaatataaa catagaggag 25560 aaaggaagct ttgtgaactg tacttcggga gggctttatg gaagtgaagc tgttgccaca 25620 gaatcctagg gaacatggat cagtgctgtc ctgcagtttg agaagagggc taggcattga 25680 aagcactgct gtggggtgtg tgtgtgtgtg tgtgtgtgtg cgcgcgtgtg tctgtgtgtg 25740 tgcatgcatg cacataaatc tagagactga atggatctga aggaggctga agagcaaaat 25800 ccaggctgca gtgagaagct tttaaggact ctcagagcaa agctgtgtgc aacagagcta 25860 aaagataaaa tgaaaaatgt actgactctt aagttgtgaa aagtcaaaaa agacaatttg 25920 acaaactcaa aacagtgaag atgattcaag aaattagagt gtgtatatat atatatgtga 25980 agatatatat atctatatat atgtgaagat atatatatct ctctatatat gtgaagatct 26040 atatgtgaag atatatatat ctatatatat gtgaagatat atatatatct gcgaagccct 26100 ccccaactac agttcataca tatatatata tgtctggata tctggtttgg gtacaaaaaa 26160 cttgctgtac taaattattg ataatatatt ttaaggcaat ttactaagtt aaaagcataa 26220 taaattataa tctattattg tgctctagag aagttattgc ttaatgagga aattaaggtt 26280 aacattgaaa cctgggaggt tctgatgttt aagtgggcat aaatcttgaa tggagttagg 26340 ctcagggcca cactgggtga tttatccaaa ttcactcact cttgattttt tgtttttttc 26400 tttgaatttt tacatggcta tggagttcaa ccataagata atttttttct gtaatacata 26460 tttatgaccc taatttaaaa aaattttatt ttactttcag ttctgggata cctgtgcaga 26520 atgtgcaggt ttgttacaga ggtatacatg tgccatggtg gtttgctgca cttatcaacc 26580 tgtcatctag gttgtaagcc ccatatgcat taggtatttg tcctaatgct ctcccccacc 26640 ttgcccccac tccctgacag gccctggtgt gtgacgttcc cctccttgtg tccatgtgtt 26700 ctcattgttc aacttccact tacgagtgag aacatgcagt gtttggtttt ctgttcctgg 26760 gttagtttgc tgagagtgat ggcttccagc ttcatccatg tccctgcaaa ggacatgatc 26820 tcattctttt ttatggctgc atagtattcc atggtatatc tgtgccacat tttctttatc 26880 tagtttatca ttgatgggca tttgggttgt ttccaagtct ttgctattat atatagtgct 26940 gtaataaaca tatgtgtgca tgtgtcttta tagtagaatg atttataacc ctctgggtat 27000 ataccccgta atgggattgc tgggcatgac cccaattttt tacctaagag ctttttatag 27060 ttctagcttt ttttagtcac aagcaggggg cctttattta tatatcccta cacacattat 27120 ttttctccat aaattgtcaa cttcctgcct tatcccattc ctgatgatga tatcctgttc 27180 ttgggaatta aggccctaga gccctagaac catcaacagt tagacatgga aggacctttg 27240 ttaattacct gtcaaaatct tctatttgaa agataagagg ggagtgagga tcaaagatgt 27300 aaattgactt ctttaatgag gcacaatatg agtggaatgg agctggaacc caaaccaagc 27360 tggcctatct cccagctcta gacagtttcc atcatggcaa acatattcat gagaagaatg 27420 ttggaagaaa ttagaaattc gcatataagc caatgcagat caatatatcc atgctagatt 27480 gcgtgattta tcacaacagc ttggcccaca atgatctcgt tggttgactg agatgggcct 27540 tttttacact caaaatttgt gaggattagt aattatatgg cattagcatt atgttcctaa 27600 atttatggct cagtgaatgc taagtatgca attgggaacg tatacacaac cattatgtgt 27660 ttggcccttg ttgtttcctg agactcaaca tcttataggg tgaaaatcca ataatgtgtt 27720 ttgacgacat agactgcccc cactgtctgg ggaaggttca catggggctg aaaagctccc 27780 ctgcctgggt gcagcccagc acagtgctgt ggtttgaggc aatctgtgtt caattacggt 27840 aaaatgttaa attagctgaa agagaatttt tctggtcact tgagtctgcc ttttggactc 27900 cattaatcat tcaatcatta aatcatttat attaaccctt tctaaccagt cctaaaataa 27960 tcagctttgt gttccgtgtt tttcctcagt tagattttct tgggcaaata gccctgggcc 28020 ccagtgaaga atccagccta ccttaggtgc tcagtcagtg ttgagcaaat gggtggatgg 28080 ctgttacgca aatgggctcc gtgtagggct tattagacct caaatcctgg tttcctgtca 28140 tacttcaaca ggaaatgcta catttgtact tcagatctaa attttatttt aaagccagaa 28200 aaagctcttt ttatataaaa taattatgtg gttattttaa agtaacaatg tctcattcca 28260 aagaccatct ctttcctttt ttggttcagc tgtgttttag acattatcta aatttagtcg 28320 ttctcttaga ttttatcaca tcttcaaaaa atgctatttt agagtaaaga atatttttaa 28380 ttgttctgtt cttaacctca gtgtccatgg agggttggag aagaagcaac atatatgaag 28440 ctgaagattg atttctaaac cttcagttaa cgttggcttt ccaagagcaa atgctcaagc 28500 gtgggataac tatcttatgt gactttgtct tttttttttt tttttttttt tttttttttt 28560 ttttttgtga gacggagtct ggctgtgtag cccaggctgg agtgcagtgg tgcgatcttg 28620 gctcactgca agctccacct cccgggttca ggccattctc ctgcctcagc ctcctgggta 28680 gctgggacta caggcgcccg ccaccacacc cagctaattt tttgtatttt tagtacacat 28740 ggggtttcac catgttagcc aggatggtct cattctcctg acctcgtgat ccacccgcct 28800 cggcctccca aagtgctggg attacaggcg tgagccactg cacccggccg actttgtctt 28860 ttttttaaaa agaaaacaac acatcgcatg ggggcggggt gcctccatcc aggcagtgtt 28920 gcagggacag gcggatgtcc ctttaccaca tcgaggccca aggagctttc atcaccggga 28980 gcttcttttt tttttttttt tttttttttt tgagacggag tctcgctctg tcgcccaggc 29040 cggactgcgg actgcagtgg cgcaatctcg gctcactgca agctccgcct cccgggttca 29100 cgccattctc ctgcctcagc ctcccgagta gctgggacta caggcgcccg ccaccgcgcc 29160 cggctaattt tttgtatttt tagtagagac ggggtttcac cttgttagcc aggatggtct 29220 cgatctcctg acctcatgat ccacccgcct cggcctccca aagtgctggg attacaggcg 29280 tgagccaccg cgcccggcca ccgggagctt cttgaagtga tgaaccacgc agtgttatat 29340 tccttttacc ttctactctg tcatataaat gatgacaaat tgcctagctg taaatttgaa 29400 agtccctaaa tggcattttt gtcaaagcct tgagaacaaa atgcttactc ggagagattt 29460 ttaagtcttg ggagacgggg tggcggggag caggcctaat tattatgcat catggcacaa 29520 tgcattatgc atcacgcttg cttttctgct ttttaaacac ttgttatgga tgatgaaact 29580 aatttaaatg gacaaacagg gcgctctcct gcacattact cctgtgatgt catattcttc 29640 ttccagggga tttcatcctg cttcccttgg aagtccccca gacatgcaca ttttaataag 29700 acactttaat aattagctta gagataattg tcagtcaagg gaaaataacc ttttatcata 29760 ggtgccttga aagtggcctg ttccagagaa gaaacaagcg atctgatttg cacttaagct 29820 tgcttccctt tccctcctgg catttatgtg gaataaaata ctacaaacgg gggagagtgt 29880 aaaaaaagga aaagtgtggg tgtggaaggg gaagccggag ctgtcaaatt gttaagacaa 29940 atggggctta gagaatccta attaaacctg aaattgctta gaaacaggaa gtatgtattc 30000 ctaattgttg gcaccaaaaa aaaaaaagaa tctaatttac tgcatatctt taaataagaa 30060 taacccatta tttggctgaa tgagaattca atccttacct attgaagagg tgaatggcgt 30120 gattttaaag gctatgaaat tcacctccaa agttcatcat cagctttaga gaatgtcaaa 30180 aaagagcgag ctcgaagcca tgtgtagaat tttttttttc tttttctcat aggtgtattc 30240 tagctttatt ttggggaaac tttagtctat tgagaccttt agaaatatta tttgggtctc 30300 taaaaaataa atatgggcat atagtctcaa gactcaacag aaaatagatt cattttgaag 30360 acaacccagc agcgttgctt aataagaaaa aaaatgtatc cccttgggct aggacttcag 30420 ttcctgggag gatgtgaaag atctctattg cagatcgcag caccagtctt tcctcctgtt 30480 attgtatctt ttgatgcaga ggatcaacca cccctggttt ttgttgttgt ttttattgag 30540 acagagtctc gctcttgttg cccaggctgg agtgcagtgg tgcaatctcg gctcgctgga 30600 agctctgcct cctgagttca agcaattctg cctcagcctc ccgagtaggt gggactacag 30660 gtgcatgcca ccacacctgg ctaatttttg tatttttagt agagatgggg tgtcaccata 30720 ttggccaggc tggtctcgaa ctcctgacct cgtgatcagc ctgctttggc ctcccaaggt 30780 caccccctct ttttatttgg gggtaggaag ggcatctagc atcccgacac ctcaaattca 30840 tcatcacatg gtgcaggaca gaactaagga caaattagga ccctttctga gcctttgctc 30900 aagcttcaaa tcacacttct tctcgtttgt acagcactta tagcactttg actttcattt 30960 atttaaaaaa cacattgaat atgttatccc cactttttag aaactgattt tgctgttttg 31020 acattgtttc tctagtagac gggaagggat aatagattgg aagcaggaac tgtggattct 31080 gcctgtggtt gcctctctga ctttgggatc tcagggatgt cagccacatt gcctcatctg 31140 tggtgacaac cacaatggtg acaggtggaa tcatgatggc tgcaaactac tgagcacttt 31200 ctaaatgcca ggcactgtgt aggatctttc atcatcacat ctcagtctca ctgtagtcct 31260 ctctcccctt tacagatgag caaactgaat cacagaaagg ttgagaacat tgctgaaggt 31320 cactagaggt gtgtgttcag tttgaatgca gatcacctga cttcaggaac agtatgataa 31380 cctaaatccc taaactcata tctcccatcc tgtctacctc acaaaattat cgtaaacaac 31440 aaagcaaacg gccataactt aggaaaaata ctttgaaaac aaggaagcac accctgggtg 31500 tgtgtgacac ttccattatt atcactttct cagcatttca tctggaaaac ggacgtaatc 31560 acagttgccc tagaagacag tggtgctcat tacatggaag agatttgatt agtggtggaa 31620 aattttgtct tttaatttgt ccagcagagg gttggtgcca gctttatcct gggagacaaa 31680 gggacctaca tttgcttata tttgctgact aggttcttgt gtctgtgtga ggggcagcct 31740 gcctttaagg cattatctgt gtcagcccag gttgagggct tagggatgga ggctgctggt 31800 ggaaacaaat gagctttgtt tagggggaaa atagccttat ctcgtggcag tctgtccctt 31860 cctatttgtt ctgagaaaat gaccaagtga taggcccttc atcatgtaca aacactcttt 31920 agattggggt tacctttttt ctttgggaac tggaactaac aaaatggcaa tgacctgaag 31980 gttgagaatg acttctcctc tccattcagc ccctaccctg tcagctgtca ctgcctgcat 32040 cactgggctg cagcatttca gcatcttctt tctgaagcag atcaaatcat gcttagaaaa 32100 tttgatgtgt ggcccttctc aagggctttt cttcacttgt ttttattttg aacttgtaaa 32160 ttgctatcac attttcaaac actgcaatca cctcgctaat tgctgttttt catgaataag 32220 aatacaagat caatggcctt ttcaatattt tcctttaccg tgaggtaatc gaaggtcagt 32280 acataaagct cctgacattt cagttacctg ctcttcctcc tgttaactgg attacctact 32340 tgcctcttgt ggttggtccc agtgttttta tttctgcctc tgcaattgtc agggtgtggt 32400 tccaagtcaa tcacatctgc aggtcaacgt ctcatcttcg ttttccatta tatccttttc 32460 ccgctcttct tcatgattaa ctaaaacccc ttgacaacaa tgatctatgt atttgtcaat 32520 gttgctgcta agcctttagc atcaccacgg tagagacaga cagctccctt cctcatcaat 32580 ccttgtgttt atgtgagcat ttaaaatagc tattagatgt aacttagaaa gaagcagtat 32640 ttcttttgtc acagcacatc ttttcaagag agattttgca cttctcactt tggtcctttc 32700 tctactacgc taaggtgtgg gacttcacac agattgttct tacattttta atgaacaaca 32760 atagtaagca attaagaatt ttagcttgag attaaatatt gaaaaatgtc actaaaagag 32820 ttacaaaaag tgcaactgga cctgtgcaga gccagagagt ctgcatggtt ctgcggttct 32880 tcatgcgcag gagaattaca cagttggcac atcccagccc atgctggagg ccacaaataa 32940 agctgttgtt tagtatgctc cagttgcatt ttggtcacat gtgcttatat taatgccttt 33000 gctttctgct tcctcttggg tattatgtgg ttgcttggct gcaacagtga attccagctg 33060 cattgatgac cactggaaaa ctgcaagaga ccaaaagatt cagggaatcg agcctgcctc 33120 atacccctca taaagctgga aattaactcc aaaagaaacc gtcaaaactg gctgtgctca 33180 ggggctcata cctgtaatcc cagcactttg agaggccgag gtgggtggat cactaggtca 33240 ggagttcaag accagcctgg ccaaggtggt gaaaccctgt ctctactaaa aatacaaaaa 33300 ttagccgggt gtggtggcgg gaacctgtaa tcccagctac tcgggaggct gaggcagaga 33360 attgcttgaa ctggggaggc agaggttgca gtaagctgag attgcgccac tgcactccag 33420 cctgggtgac agagcgagac tccatctcaa ccaaaaaaaa aaaaaaaaca agaaagaaag 33480 aaagaaatcc tcaaaactat acaaatatat ggaaatcaaa taatctgctc ttgaataatc 33540 attaggttaa caatgaaatc aagacggaaa tttaaaaatt ctttgaactg aatgataata 33600 gtgacacaac ttgccaaaac cactgagata cagcaaaagc agtgctaaga gggaagttca 33660 cagcattaaa tattaaatgc tgacatccca aagcctgaaa gtgccaaata gacaatctaa 33720 tgtcagacct caaggaacta gagaaacaag aacaaatcaa acccaaataa tacccctgtc 33780 ttcatatacc acagttattt agattaatca acatatgtgt ggtctcatag gttctcttgc 33840 ccaaccatgg tttttaggtc agagagatgt gggttcaaat ccaatcaact cttccctagc 33900 cttttatgga atgaaatggt gtttcatttg tgccgttatc aatcatcatc tctattatac 33960 tctttaggat atattaggct gcacttttat gcgcatgagc tttttgtatt tctcctcgta 34020 tttcaaagcc agagttctct gaagacatgt cgaaacccat ttacttatct ccctgcctat 34080 actcactcaa cacctggtga atttccatct gccattcctt tcactaaaac aatttacccc 34140 aagatcacca gtgacatacg tattgttgaa tttagcaggc aattttcaat cctcacagca 34200 gtttccaaca ctggtgacca caatctcttt actgaaacaa tctcttgctt tggcttccaa 34260 cttcccactt tctccctcct tcttttattt ttctagtctc tgtatcaact gggttgtgcg 34320 tgacctttaa gtgaattcct taaagttcaa accaaggctc tcctctatct ttattctaca 34380 tcatcttcta gaatgataaa tgtgtgccca taactttcta tttcctactg tactttgagc 34440 ttcagaccta tatgttcaat tgtctggaca tatccacttc gaactctcaa ggtttcttct 34500 aaagctagta atcctaacca agttccatct tctccctctg tggcccacaa atagccatac 34560 cgtgagagtg tgggtagtca tggttcacat gtatccaaaa agagagcaca ggtaatggaa 34620 gggaatttag gtgtcttggg agccatggtg tgatttcttg atgagagctg tggctcaggg 34680 gtcactgtct gcgtgctggg cacagtgtga cagtagaatg catggactcc caagctgaag 34740 atataagtgc tgggttatct aggaagactt ccttcagaca ctggtgtgat ggtgctgtca 34800 ttgacctgag tacctgctgc atggaagggg agaacatatt cttgctaaga ctgggtattt 34860 gagatgtggc agtttatgag gtcagatggt aacgatttct ggctctcagt tgatttgcta 34920 tatttttctg attcaattct gtttctctgg ttatatctgt tatattcctg ctctccctta 34980 cctgtttcct cacatctaaa gaatacttca ctcttcactt actcactggt attttccctg 35040 taaacctcta tgccttctcc tgatctattg tttatctcct tgtaagctaa ctcttctact 35100 ctccaatacc aggaagatgg gagatgaaga agaaatattc tctttttgct gaagcaagga 35160 tgcctcaatt ggagaacata gtgagagtga atcacaacct aaaggcacta agaagtgaga 35220 aaggccggaa cagacaccaa agttgacttc cagtggtccc aggtgcctat cccatatggg 35280 accccatagg tcttcaacgc aatctactca gcctggctca gcccacagag aggttctgtg 35340 ggagataaag atttctcaaa aaaccaaaat gagaaagaaa ggctaggcct ggaaagtgac 35400 ccaaagctga gttaactgct ctctcagcct ccaggttacc catgaggatt tctcctttct 35460 gtctgcatca gcctttgttc tgtctttgca gactgccttt atctgcttct ccagcatgga 35520 ccacctggtt ctgctgctcc agggccccct tcccaatttc tggtggaaag aatctgactc 35580 cacgtgcgcc cattgatggg tgaacgttaa aactctttag aacacacttt cttttccaga 35640 attcatgttg atgaacttgt aagaataatt aaatcaatta aaattcaaca agcatcaagt 35700 atttggtagg ttatcaggta cttgactgag tcaattcagg atttaatctc aacaggtaaa 35760 agcttaaaaa ggaagcaatc atttgaatta atgtttgaaa tgcagagcca caaatactaa 35820 tttgggggtt ctggctaata tataacaccc tcgaaaagtc tgtttgtatt taaatatcac 35880 atggaggctc tgtttcttgc tccttgactc tgcacgctgt agcatgaaag tgatgacatt 35940 ggactctctg tcttctctgg cagaagccca ctggaaagga tgtgagaaac cctgactagg 36000 gacacactga gccttcccat attatttaat gacagtctgt gccagggcct ccattaattt 36060 aactgaatga aatattccta tctggggttt caatagccct tcactgagta tctcctatac 36120 aatgtcccca tcatggtgta gcctctcatt gcaaacatac aatgacccca agtgaaaaaa 36180 ttatttttat aactatagca ttttttttag agacagggtc ttgctctgtt ccccaggctg 36240 gagtacagtg gcactatcat ggttcattgc agccttgaac tccaaggctc aagcaatcct 36300 ccatcctcag cctcctgagt agctgggagt acagtcacac accaccatgt ctggatagtt 36360 ttttaatttt tattttgtag agatagggtc ttgctatgtt tcccagactg gtcttgagct 36420 ctcaggctca agcaatcttc ctgccttagc ctcttgggta gctgggacta caggcatgtg 36480 ccaccacatc cagctacaaa aattttcatt attacctcag ctggacaagc gagaaaactg 36540 aaatccaggg aggttggagc tgggtcagct aattagtgat ggggccagga tccaaaccca 36600 gatctctctg actcaaaagc ttaaacactc tacccaacct tcttgtgttc ctggtttacc 36660 agactaccca ccaggaacag actcgggacc tactgggtta aggagaactt ctaataaatt 36720 catctctttt tacatgactt ctctccccct tttcagcaaa tttctggagt agaaacaatt 36780 tacattcttc taagataatt ttcttccccc tgaagattac cacacactcc ttcctgtgca 36840 cagacctgag ggtgcaacgt tctagctcct caggaacttc tgagagggtg aatcgcagat 36900 ttggatcagg gtgaaggcta tgtttgatca atgttgttcc acaaggagat gcacagtaac 36960 atttagacta caaggaaaag cagctccagc cctcttcttt gtctgcaagt tcagccacat 37020 gggctgtaat ctcatagttt caacagaggg gcctgctgcc tctggcctta ctgggcagca 37080 ggtggtgggg acggctgttc cttctggagc gacactgcca tctcgcctga agtcaggagg 37140 caatggtgca atgcactgct aatatttttc tcctgaagac tgatgacttg ctggatctgt 37200 agctaaatgt cttgtctcat tttcacagcc acgtcatcgc ccttttccta gtgcttgtga 37260 gtgagtcacg tgcaagggcc atctgggagg aagcgttctg ttaaaccttt ctttaaagca 37320 tctttttgat gtcctgggaa atgcacctgc ccactagagt tcaattcagc aaataattgt 37380 taaatgatca ccataggcag gggacttgct atgaatataa caaagatgaa aatgccagtt 37440 gacagaagca tgacgtctcc tagaggaccc agatccaagt gaagcaagtg cagtccaagg 37500 cagggcaggg tctaggctga cagtttacaa ggctcagttt cttagccact tacctacttc 37560 tgaaatgcat tcttatatgt ttaacatctt tattgagcga taatttacat aacgtaggat 37620 tcacttattt taactgtatg attctctgat tcttaacaag ttcacagagt tgtacaacaa 37680 tcgccctttt agaactaccc ccaaaatatc tctcatgcct atttgaagtc acttcccatc 37740 cctgctttga agtcccaccc ccagtcaaca gcttctgtct actttcttta tagatcggct 37800 tttcctcaaa ttaggatctg cttctggaga actcacacca agacacggcc ccttgtccag 37860 tcttatgagc taccagtctg tcctgggaca tggtggcagc tgttgtctct tgcctttatc 37920 gtggtggtgg ctgtgctgac ctggggaacc ctggaacttc tgctatcaat cccaacaggc 37980 cagagctagg tggatgctct ggtctcatct cattggatga gacccctgtc ctgccctaac 38040 agtcaggaca agggtctaat ccaatgaaga ggggcatcaa agattgttca agaacaatca 38100 gattgaccat gggaatgggt cagtggtgag catgtaggat agtctctggg gtagaagtta 38160 gatgctaggc gcaggttaag gagcctggag ctgatggtcc aggagggtta tgtcacctaa 38220 caaagcagag agtgtcagct catctgcaaa tggcgtttgc ctttggggta attccagccc 38280 acactgaata gcaggtccat gtgtaatctc caaagtcttc ttcaacttta tgagaatggg 38340 cctgggcatg gtggcacatg cctgtaatca cagcacttta ggagggcaag gtgggaggat 38400 tgtttgaacc cagagtttga gacctgcctg agcagcatgg tgaaatcctg tctctacaaa 38460 aagtgaaaaa aattaggtag gtatggtggt ggtgcacctg tagtctcagc aactggggag 38520 gctgaagcaa gaggaacact tgagcccagg agattgaggc tgcagtgtgc tgtgatcatg 38580 ccactgcact gcagcctggg tcacagagag agactatgtc tcaaaaaaaa aaaaaaaaat 38640 gatggttgta ttaacccaag gcctacttag aatctcaaag acctttctct ctctcctcat 38700 ctcctgccag agcttgacca ctctgtggtt ctagctgcac ttttatcact tctctgttct 38760 acttgcaaga tggcttcttt tcattttttt gtgaactttg ggtctgtatg ttgtcagcaa 38820 tcttcagtgg gcatttttgg gcctcttggt cttcttgtgg tctggtgagt agagatgttg 38880 actgatacaa ggacagtgga attcccccat tgcttcaata attttaatag ctgacccttt 38940 gaggaacatt gaagctggat ggtcattcag acttgtccca aattgagttg ggctccagca 39000 acacccattg accagtcatt ggatgagtga tgtctttggg gaggaggcgt ctttggttga 39060 ggtcatagaa ggactcagct ctgaattctt tgcaaacaac acactcagca gatgaggaga 39120 tgtgtactta ggcccagaag taggaatctg gacagcagac cacagtttct actatagaca 39180 acaaaagcca cacagtgaac atggagctaa aagtcactgt ggttcatgaa ctataatata 39240 cctcacaata gcatgctata atatgtaaaa atacccctcg gacagataag agaagaaggt 39300 ggatagaaat tcaggctttt ggcccttttc accacttccc aaccctcttc cctttttctc 39360 tcttctcttg tctcctgcca gagcttgacc actctctggt tctaactgca cttttattac 39420 ttctctgtcc cacttgaaag atggcttctt tttattttgt tatgaccttt gggtctttat 39480 attgtcagtt gctataaatg aataaaggct ttttccttct tagtgtgttg gtgaagaact 39540 aggagtattg cactcactga tcaggaggga acaggtctag ggagtgcata gaagctttcc 39600 aagaggagtg gacaggaagc ctgtcctccc cctcgccctc cacccccatc ccgccccacc 39660 tcctgcgaag gcaggaggac catgaacctg caatttggct gatggcagtt aaggggtaat 39720 caaaagtcca ggcataggaa ctggttcctt agtgtccatc caaagcctca agaggctgac 39780 ctggaaggat gcaggtgtga gaagccatgt gtggatccca agtttaagga catagatgtt 39840 ttccttacag aaatggaatt tggacactat atggttacgt ggtcagccag caacagagtt 39900 caataataat aaacccctaa taaaatattt atgtttttcc ttatattacg tttctcctat 39960 gaaacactta ttgattgatt gattgattga ttgattgatt gattcattat actttaagtt 40020 ctgggataca tgtgcagaac gtgcagattt gttacatagg tatacacatg ctatggtggt 40080 ttgctgcacc catcaaccca tcatctacgt taggtatttc tcctaatgtt ttccctcccc 40140 tagcccctca cccccgatag gccccggtgt gtgatgttcc cctccccatg tccatgtgtt 40200 ctcattgttc aactgccacc tgtgagtgag aatatgtggt gtttggtttt ctgttcttgt 40260 gttagtttac tgagaatgat ggtttccagc ttcatccatg tccctgcaaa ggacatgaac 40320 tcatcgtttt atatggctgc atagtattcc atggtgtata tgtgccacat tttctttatc 40380 cagtctatca ctgatgggca tttgggttgg ttccaagtat ttgctattgt gaacagtgcc 40440 gcaataaaca tacggaaaca ctaatttctt agggtgatga aactaataga aacacagccc 40500 ttgaatgtat ttgtacatat tgtagcattc acaatttttt cagacctcat aattgtcaaa 40560 atgaagggtg gattttgagt acctctagga tttggaaata aattatgtga ctttttaccc 40620 aaggtcattc aaagacgctt gtgtagcaac tctatatttg tattgcaaga gctagactgg 40680 aactttaaaa tatcatcaga tctctgtcag gtaaactcac agaaatgagc ttattggtca 40740 acacactttt ttttgcatct tcagggtgcc aggcactggg agaatcgggg caccacagat 40800 ctgactcccc acttggtgga gctgacagta aagcaatcac gtcaataatg gcagcattct 40860 gcagcatatc aacagcaaag tagaatgcac cttggaaggc cacagtgggg acttaatcta 40920 gcttgtgggc caggcaggaa agaagggcca gcctcatagt gagaaggctt ccagggatag 40980 taaatcatga tgtgctgaag gatctgagaa gagcccagca gggctgaggt gtagcaggca 41040 ggggtatcgc agtaaatccc cagcaggaaa cagatggcag gctcatctta gaaaacattg 41100 tgtttaggcc aggtgcggtg gctcatgtct gtaatcccaa cactttggga ggccgaggcg 41160 ggcagatcac aaggtcagga gatcgagacc atcctggcta acatggtgaa accctgtctc 41220 tactaaaata taaaaaaatt agctaggcgt ggtggcaggt gcctctagtc ccagctattc 41280 gggaggctga ggcaggagaa tggcatgaac ccgggaggtg gagcttgcag tgagccgaga 41340 tggggccact gcactccagc ctgggtgaca gagcaagact ccattaaaaa aaaaaagaaa 41400 agaaaagaaa gaaaacattg tgtttaataa agggaccatt tactatggta tgggctgagt 41460 gtcaggacaa caggctagat ggtatagggc tgtgtgatga tggacttgcc accatcctta 41520 ggcctggagg ggtcaagggg tcatggcgta attcccagaa cctggaaggg gaaggaaact 41580 ttggttgacc aatggaacaa gctaagtagg ttcattgggg agtgagccaa gggaatgagt 41640 tactgagttt actcttctac tgccttccag tctcctgtct ggactcctgt ggccctgaac 41700 acaccaaaag tcagagggca tggaatctca ctgatgtcat gattactggt cagcctcatg 41760 agccagaagg caggatggag ggggaatgaa caaacagaag gaaccctcac aaaacagaga 41820 gggggaaaga gagatagaca tacaagagag agctaggaaa gttggcagtg gccagatttt 41880 aagagatact tggctcatat taagattaag gtttacttgg aagtcactgg gcagtcatct 41940 gtgtgatcag attattataa gaagagaagt agcagactgg agggtggatt tgagaggagc 42000 aagggtggat tctagaaggc catttgggag gtcatgacag ctccctagga gttgggggga 42060 agtgagctaa ttcaagaata ttagaagagt ctcgttcaga cagctgagtg gacgtgcctt 42120 tcactgattt aggaaacatt agcattagac caattatggg ggtggggaag gagaaagctt 42180 aagtgcaggt gtgatcatgg tcagcttgaa acacctctga atacaattgg gtggggtaca 42240 atgtagcagc gggaagttaa gtctggagct cagtagatag tcctagatgg aggggaatgt 42300 tgacttatag atgggaattt agcaatggat atagtagagg tctctaaaga gcacaggtag 42360 catgaacaga tacagaaggc ctaggacaga atccataaaa atgtcaacat ttcaggattg 42420 tgcagagaca gatgactgag taaagaagac tgagaaggaa cagataagta gtcgaaaacc 42480 aagtgggcag ggcaggaggc aggttagggt gagttgcaaa gtggctgaga aatgagaaaa 42540 tgaaaccgtg ggggctctca tcttctccag gaaggtgtgc tgggaacggg gaggggagat 42600 aggggctagc aggcagaggg tggtaggagc agagagagcc ctgctgggaa aggaggactt 42660 gagcctacct aaatgatgac cagagtcagt ggagaggcaa tggcaatgga aagaacaagg 42720 gtccaggagg aacaggataa tcatcaggga aaggttggaa tgcggaaggc aaccaaagca 42780 tcctgcagag cgtgcatttt gaatttctgt gatcctctgg aaaaacaacc ttctgtgctt 42840 caatttaaag gaaggtgcat ggactctgtg ctcccctgat tctgaaccac actccatcag 42900 caaggccaca tccacattca gagctccagg aagcctcccc tatccctgtg gacaggactt 42960 ggggagtggc cttgtactgc acaggtcact gtctccattc taacctaagt gagggaagag 43020 tggattggtc cctggagtgt ttacagactt ggtgctgatg gaggggtggt ttaaaggatt 43080 tttagctatt tccccccttt ctttattaag cagaagagaa gactgggtcc tgagagtaaa 43140 gagtctgagg cttgagtagg ttagagaagg agaaatggtc attttgtaga gcaggagagg 43200 ggatgctcct tagagacact gaaggaccat ttaggctggt gacggcaaat ttattgtgac 43260 acaaatcttc ccagctgtgg gattttcccc aacaacactc aacggtccag acacaggtat 43320 aaaggtgttt tttttttccc cattcttccc ttcctctttt ccttcctgtc tgatctatcc 43380 aagttggagt tcattaccca cagattctat acataaatgc cagtatattc tatatatact 43440 aaagtctgta gattctagta attcctaact caccaaccaa ctacaaggtt taacaataat 43500 agaatcacac atatgtcacc tttctaaatc attaacctga gagacgaaag agaaggggga 43560 gtctgggggc ccgagatcag tgactagagg gtgttgcagc actaaaacat cacacgattg 43620 atcagaccta tcatggctct ttcactttca tgaacatttt gtgttttgct ttaacagaat 43680 ttgagtcact cctataggtg gctttagtgg tccttccctg ggtgttttct cagacttgtg 43740 gtgggtaatg gggtagcata tgtgtgctca cgtgacagag tggagttctc atcatttcac 43800 tgccttcttg gcaaacagag gcaatgagaa cgtcaaaggc atcatttgca tttgtaaagc 43860 aaaagccagt gatcacatct gtatctacca tatggcagat gttccataat tattttgaaa 43920 aacatatgag atttcagctg tgcagcactt attggagact tgaggaaaga aatttagggg 43980 caagaaattt aggaatgagt attattttcc tcttagaaac tgacttctct gacttaccct 44040 aaatttagta cttccaaaga gaataacaga ttttcatcat tgtaaaatat cagcaaaaac 44100 agaccaaagt gctgccataa ggaaaggaat tctgttagtg gtaccttgtc tgtctagttg 44160 tgaggtgtgg tcagctgcgt aatgctgtca cttccccagg atatccatgt ctgtattagt 44220 ctgctttctg ttgcttgtaa cagaattcta gaaatgtgta atttataaag aaaaggaata 44280 tggttcttac tgttatggag gctaacaagt ccaaggtcaa ggggccacat ctggtgaagg 44340 tcttcttgct ggtgaggacc ctttgcagag tcctgaggca gcccaggcca tcacatggtg 44400 aagggctgag tgtgctgctg agatttctct ctttctcctg ttacgaagcc acaaatgcca 44460 ctgctgtgat aacccatgaa tccatgaatg gattaatccc attgtgaggg ctatgccctc 44520 atgaccaaat cacctttaaa ggccccacct cttaatactg ccacattggg gattaagctt 44580 caacattagt ttcagaggga gtaaacattg atatcatagg cttttgcccc tggcccccaa 44640 aactcatgtc cttctcacat acaaatatat gcaatccatc cccataaccc caaagtctta 44700 acttatcccc acaccaactc ggaagtcgaa agtccacagt ctcatctgtg agtctgtgaa 44760 atcaaaacgg gttgtctact ttcaaggtac ctagaaagac tcacagattt ctattttcaa 44820 agtgataaat aggcaaaaag aaaggcttaa ctagtcccaa ccaagtctga aacccagcag 44880 ggcagacatt aattgtaaag cttgagagta atctcctttg actccacctt agcctccgag 44940 acactggggt gggagttggg cccccaaggc ctcaagcagt cctgtccctg tggctttgct 45000 tggtgtagcc catgcagcta cttctatgtg ctgaagtctg gtccctgaag ctgtccaacg 45060 tgggcattgc atgctactgg tgactccaca gttttgggat cctggtggag gtcctgcctc 45120 tatggctcca ttagatatta ccctggtaag gactctgcag cagctctgac cctacagtta 45180 catacagcat tgctctagtg gaaactcttt gtggtggcaa ccccccctgt gacaagtccc 45240 tgcctgggcc cccaagcttt tgatgacatc cttagaaatc tgggtggagg ctgccaatcc 45300 tctacaactc ttgctttctg caaacctgag aattagcacc acatgcatgc tgccaagagc 45360 ctgcagaatt agcgctacat gtatactgac atgtgtattc cttccagagc tgtgccacaa 45420 gccataccta gggtctcttg agcctaacta gggcagttgt ggagcaccgt tctggagtgc 45480 aggaaacaga gtcctctggt ggccttgggc actgagccta tggagggtgc ccttggtcta 45540 gctcctgaaa ccattctgcc atcttaggcc tctgggcctg tgatgagaga ggcagcctca 45600 agatctttaa aatgccttca ggatctcttt tttctgctat cttgaggaaa agcacctggc 45660 tcccttctat tcatactaat atgtttagca aatggtctct gagctacacc cttgattttc 45720 tctcctgaac acacttatta acttttcact tggccaagat gagagctttt caaatctttc 45780 tgttctgttt ctcttttaat tataaattat gtttttaaat tattcctttg gtcccaaata 45840 tcagcataag cagccaaaag taaccatgta gctcctttta tattttcctt agaaatgcct 45900 tgtgtcagac caaggcaggg ggatcacaag gtcaggagtt cgagaccagc ctggccaaca 45960 tggtgaaacc ctgtctctac taaagacaca aaaaattatc caggtgtagg ggtgggcacc 46020 tgtaatccca gctacttggg aggctgaggc aggagaatca cttgaaatct gaaggcggag 46080 gttgcagtga gccaagatca agccactgca ctccagcctg ggtgaaagaa actccatcta 46140 aaaaaaaaaa aggagaagaa agaaagaaag aggagtttga gaccagcctg accaacatag 46200 tgaaaccccg tctccattaa aaatacaaaa attagttggg cgtggtggtg tgtgcctgta 46260 atccaagcta ctcaggaggc tgaggcagga gaatcacttg aatctgggag gcagaggttg 46320 cagtgagccg agattgtgcc actgtactcc agcctaggca acagagtgag actccgttta 46380 aaaaaaaaaa aaaaaaaaga aagtaagaaa gaagaaagaa gaaatgcctt gtgtcagata 46440 tcctagttca tcattcttaa gtttggcctt ccataaagcc cttgggcagg gacacgcttc 46500 aaccaaatta tttgccaatt tataggaaga atggccttta ctcaaaattt caataccttg 46560 tttttcagtt ctatctgaga tctcatcaga atggccttta ctggccatat ctctattagc 46620 attctggtca ccaccattta accaattcct aaggagttac aaacttccct tagttttctt 46680 gccttctaag ccctcaccag aatccaggct ttttctagcc tgctccctca gcttccatcc 46740 tctgcccatt acccagttcc aaagccactt ccacattttc aggtgttcac tatcatcaac 46800 accccactcc tggtaccaat tttctgtctt agttcgtatt gcttataaca gaatgcctga 46860 aactgggtaa tttataaaga aaagtaattt atttcttaca gttatggagg ttgagaagtc 46920 caaggtcaag gggctgcatt ttgttgaaag gtccttttgc tagtgaggga ctctgtaaag 46980 tcctgaggtg gtgcagggaa tcatatggtg aggatgctta gttattgttc aagtctccgt 47040 ttttcctctt ataaagccac taatgtcact cctgtgataa tctattaatc cactgactcg 47100 ttaatctatt aatcaataaa tggattacct cttaaaagtc cacatttcaa tattgccaca 47160 ttggggatta agtttcaaca tgagtttcag aggggacaaa cattcaaacc aaagcagtgt 47220 actgtctcca aaacctgtaa atgctacctt atatggctaa aggaattttg cagatgtatt 47280 taaatttagg ctcttgagat tagaagatta ttttggatta actattaagc ctaatgtaat 47340 cacaagaatc tttaaaagag aaaggcagga gatcagaagg atagtaaaag atgtgatgat 47400 ggaataagag gttggaatga tgtgtctctc ataagccaag gaattcaaga ggtctttaca 47460 agctgaaaaa gactttatga ggtggaaaag ctttacaagc tgaaaaaggg aaatcagata 47520 ttccccatgt tccttcaaag ggagtgcagc ccagtttata tcttgagttt agttctgtga 47580 aattgaactt ggacttctgt cctccagaat tgtaagagaa taaatctgca ttgtttaaag 47640 ccaccaaact tggggtaatt tgttatagtg gcaataagaa tctaatactg tagaataatt 47700 tactttgagt tttttttctc tgagtttcac caatcagcta ttccaatgta tattcattat 47760 tgattttcct gcatagggaa ggtaatgtca gcaataaatt tgagttaatg tgttagctct 47820 caatttacct attggcaata tagattcaaa ttagagagga agcatcacct accccaaagc 47880 cccagcaatc tagttctttt aactcatttc actcccagag taaaacaggt attttggtaa 47940 gggaatcact gatgttactt acaaacacag gctctcaatt aaaaaaataa aattttcttt 48000 ttggtccaag ctttctcttt acacacctca ataccatcct ttgcctacaa acttaactgt 48060 ggatatctaa aaatgtcttt atagggtaat aacatttttc caaaagtcag tagcttaatt 48120 ttagaagtaa aacattttaa tggcttaggc tatagtttta tagcattggg aatggaattt 48180 tcctgttttt atggtaaatt tgtttatcta aattgttcta attttaatct ctttaatttt 48240 gtatgacctt tattttattt ttaattgaag agcaatatat actgaatggg tgaagtttgt 48300 aaaacacttg aaacacacaa aaaagcaact cttgtagttc tacaatgtag agagatactg 48360 ctaacagtct ggtatgtctt ttattaaaca tttacaatta ggtgattgtt ttattctttt 48420 tttactgctt catgaacatt ttcttcacat cagtagacgt tcttccatat tacacttata 48480 atgacaacat cctagtttat cgtatgtatc tgctactatt agctgatcct ctactgtaga 48540 ttcaggtcat tcctgaaata ttattattgc caattcatgt gctttgctca tttctttttt 48600 ggtgtgttat ttgaaaaata ggtttgcaag cttttataaa tgctaggctt attaattttt 48660 aaaaggtatg tataatcttc aaaggtcatt atttgccttt taattttgtt tatggtgagc 48720 tttattgata tataagcatt aataaatttc atgcaatcga aactacttgg cattttcatt 48780 tagggtgtgt ctgtgatgat ttgtattctc ttttttttta cagataggtt ttcttttgtc 48840 ttgatggtat actggatttt aactcttttc ttcttttaga tcaaatgcat atttccttct 48900 tcgtggtgga gcagtggtgt ttttagtcct taactaacca cttagcttat tctgtattaa 48960 gaacattttt tcccacttag tatatttttg accctaaatc tgctggctaa cttgatagtc 49020 tgattcatct taaagcggct ccaggctgaa ttcaattaca aacataagga tagtattact 49080 atcttctgta aatatgcaca tacttacatt gtgagttaaa tacctaaaaa aagtaatgtg 49140 catctaatga aggatctttt tttttttgtc ccagatgaca agataaaatt cttagtacat 49200 ggtttccatt tttcatattt tggtaatgtc cccactatta acaacataaa ctgataaatt 49260 agaaaacacc agatccttac aactgtatta aatttgaaga aaaaaatgat ttctttctat 49320 caaggtagag aaaaaagaag ctgaataagc tctgggtttc tggaatgtct ccattcagct 49380 ctttctctgc ttatgttcca aacaattgca taaaagcaat cccaaacaaa tgtttatagg 49440 gctgcactcc gaaataaaga taatgaattc tacataacaa gtacactctt tcccctggct 49500 gtttgcattt aaaatgtaca ttttgcagta attttgatga cttcattttg aagcagttct 49560 taacagacat tttggaaatg tctcatgtca tgaatttatt cataaaccag cctgtcaaaa 49620 accttagtgt tcactgggga gaatgtgtct caaatgcaca agtggttgtt ccacctacat 49680 catccaccat cttgaaatat cattattcat ttccattact tcttggatgt tctggttcac 49740 tgctactggg tttcgcaaca gtgtggagaa gagaccatga cattgaatta ccggctaagc 49800 agcatccata agtgttatat tcctccctta attatgatga gaacttgtgt ttaggaagct 49860 gtgatgttta ctgatatggt taatggtcaa tgtcactcat caaaagggtg ataagacaat 49920 aatgggatct tggaacaggg aagtcaagat aagcacaatg tgtcattttt tcccctacaa 49980 gcatacagtc cttaatgaag acaaataggc cctaatgttt atttgttcaa tgaacatgct 50040 attggattgt gaacaagagg tcagcgtgac tagcaatgag gtgtaagctg ctctatcaaa 50100 gggtgatatt tagtgactag agcaagtcct agaatgtttt acagtaaacc attgtagtta 50160 caacacattg tttctacccc tctgatctcc aagagacaag gaaaataagt ggatactctt 50220 gtctttccaa tctggaaaat agaattggaa gtggatgctt tttttcattt ctaattcata 50280 gctctttgat cttgattatt catgaagcat atgcgtccat gaccatgtgt taaatcagca 50340 cttatcatat tttattgtga cattcattcc tgggaatttt attaaaatgc agattcttgg 50400 gtgggagctg agattctgca tttctaacca gctgtcaagt attactcata ctgtttctgg 50460 tccatggacc atactttgag tagctgactg attccaactt gcaagacaga gacagcagaa 50520 cctgcctaca tagatttaga accttgtctc ataatagtgc atgtatgctt agtgaggcag 50580 catagtaaca tggataaaag tgcaggctct gggtgtgaat tctaccacta cttttgctaa 50640 gctttgtgta gtgccagtca cccctatagt ctctgtgatc aatgacaaca aagatttatt 50700 ttgtgctcac attacgtgtt ggactgactg ttggccacaa gtgtgcaaat tctgggaacc 50760 actttaaaga cagccttctc tgggacatgc cattttaccc tcatcttttg ggaacctaca 50820 atgactaaaa cttctgctcg gatttgccga tgtcatgtcc actcacatgc tattggcctg 50880 agtcaggaac atggccaagc ctgatgtcaa tgaagcaggg aagtagactc cttctgcaca 50940 cagcgtgtat agacatatgg cctcctgcag gaaagggagt gaagagttgg gacaagaaca 51000 cacttttcca ttgtgactta gtagctatgt actcttgtta ttttcacagg attgttttga 51060 ggattgaata agctaaaatg gatagtacat tgtacctaca tgacacttag gagaagctca 51120 ataaatgcct gtaattataa ttgcttttgt ttttgttctc atacttcacc ctagtcctca 51180 ctgcacagtt gctgtaccct tgaggttgag aaaagtccct ctccctgcct ttcatgatac 51240 atgaaacata ctgaggccca ctaaatacca aacaatcaga tcatctgagg catctgcagt 51300 taaagaaaac tggattacta cacaatcagt tatttccaaa taattttaga caacgattga 51360 cttcttcctg gccatcatat tttctgagtt tttgacttga gtttcagatc actagatttc 51420 ccctgattat tctctgaatt tgttttatgg cctgttcttg ggtcgtttgt tctacagatg 51480 tgtactgagc atccagtgaa agtcagctgt tgtgtgagga gcaaagattc atataaagtg 51540 tggttactat ttaatgaaag tttgtgagta cactcttcat agacgccctc attcactgtt 51600 atctaattgc caggcagtgc tggatgaggg tgcaaaggtg aaatccagcc taaataaata 51660 ggagtctggg gagcttgagc atatttagtt agccaagggg aatcactata gcttgtgaac 51720 agtccaggaa tatgaccttg gatttcgaaa aaaaaaaaat tgtgggtagt atatgtaagt 51780 tgttggagcc tctgccattg ggcacttggt ggagtgagat tatagggctg tgagccagag 51840 catggtgtag tgaatgggat agatgtgttt gtgtgagagg aaaatatcca gtggctgcat 51900 agctctgaag attatcagtc caggcaattg tggacaggca ataagtttat gtgatggagg 51960 aggtagtgca ttcaactggg gccgagagtt tgcgttgtga atagtataac aagacacaga 52020 tgttggaaaa aggggttcaa ataatttgca gaccagctat ccaggtcaac tagctgatga 52080 tccatgacac agtgcatgtt aaaggcctat caatcttatt gtgtagaagg agtatagacc 52140 aagggatacg tagtcattaa atgctgaagg ttgagatcct tgttgatgca attgttcact 52200 ttactaagag gtactttttt tttttcaatt tgactaagaa caggcctgaa gattatcagt 52260 ccaggcaatt ttggacaggc aataagttta tgtgatggag gaggtaatgc attcaactgg 52320 agccgagaga ttgtgttgtg aatagtataa caagacagag atattggaaa aaggggttca 52380 aataatttgc agaccagcta tccaggtcaa ctagttgatg atccatgaca cagtgcatgt 52440 taaaggccta tcaatcttat tgtgtagaag gagtatagac caagggataa gtagtcatta 52500 aatgctgaag gttgagatcc ttgttgatgc aatggttcac tttactaaga ggtacttttt 52560 tttttttttt tccaatttga ctaagaacag gcgtgcttta ctcataacac acttgttttt 52620 ggtgcagtat atcgcaaaac aaagttgctg tgttaagttt aactgtgatt taaactgatg 52680 ttgcctgagt ccccaaagac caatgaaaca caagtgggat ggaaaaagca gccacttcta 52740 ttgttgccaa atgatagaaa agatttgaaa aatcaaatgc atcaggttag cctcactgtg 52800 cagcaaggaa aaaaatgaat taattataaa taagatgaat aaataattta aatatatcac 52860 ttattgcttc tttattgctt aacacttgaa aaattgtttc aattagaaac ttaaactcaa 52920 tttgatagac gaagagtgtg cagctcaaga taaatgtaaa tccctttgcg atataaaaat 52980 ttgattttgc agtatgagct ctattaaaaa gaaattaata atctctagaa aaagaaggca 53040 gtgccaagga aggttggcct tttcccacag aacattgctt tttaagagga aaaatcagta 53100 agcttattat agagaaaatt ttttaaaaaa tcagaaacgc aaaatactaa ccaccaaccc 53160 cacaaacaac aaaactaata agcatttgtc tctctggatt tcatattaaa accgtagagt 53220 aggtttttgt gcttcttata tttcacatga ttttttgtct aagccagaca aaatgcttca 53280 ttctctcttt gagtttgttg ggcctataaa aaatggtaga acagtccagg catcgtggct 53340 catgcctgta atcccagcac tttgggaggc cgaggcaggt gaatcacctg aggtcaggag 53400 attgagacca gcggggtcaa catggtggaa ccccgtctct actaaaaata cgaaaattag 53460 ccagccatgg tggcgtgcgt ctgtagtccc agctacccgg gaggctgagg cagaagaatc 53520 attggaaccc aagaggcaga ggcttcagtg agccgagatc acaccactgc actctagcct 53580 ggggacagag tgagaccccg tctcaaaaaa taataataat aaaataaaac accagaacaa 53640 tttcatattt tttgtaccta aaaagcaagg gatttatgta tctgaagtca caatggacct 53700 tacccaagac aagagtatcc tggaaagttg ctttgattcc tgtgccatca tgttctaatg 53760 ctgcaaaccc tctctccgca ttcttggcag atatggccaa ttaatgagat catgatcttt 53820 tgtatgtcca gtctaaacct cagaatccct cccatcacag gcctccagcc agccacttct 53880 tggcacgtgg tatgaaacct actgcccatc tgtcccagca gctgaaggac taagagttca 53940 ataacatttt atctggcaca tgaacaattt gcctgatttc ttaactacgt gcaaacatct 54000 atcaccttat gttttagttc agtctgcaga aatgagttct ttctattatg tatagaaaaa 54060 aagcaaatgt ctcaggaaat tatgtggcct atgtatttta ccttttggac ctaaatatac 54120 atctaagaac taaatatggc ctgagaatca gctcccctcc tccccagaat ctcataacaa 54180 actgaacact catcatccat caaaaagcaa acacaaaata agaaaacacc agctgggcca 54240 caaatgccag tccaggcagc tttcaattaa cattcagagc tgtcagaaac tctacagcag 54300 gggtagaaaa cggatggtct cagcccacag atgtcttgct tggccagaag gagttttatt 54360 tctttattct ggccctatgt gggtcccctc ctctccaggt atcataggct tccatactgc 54420 cccattctct ttatcccagt gacatctgaa gacccctgac tttgtgattc ctgatggcag 54480 aattctgtct ttcctcattc tcagtcacat atccgtttat ctctctttta tggactgaat 54540 catgttcctc cagaattcat atgctgaagc tgtaaactcc taatgtcact gtatttggag 54600 ataggatctt taaagaggtg tctaagttaa aatggggata ttggggtggc ccctaattcc 54660 atgtaagact ggtatttaag aagaggagat ggccgggcac ggtggctcat gcctgtaatt 54720 ccgaggcagg tggatcacct gaggttagga gttcaagatc agcctggcca acatggtgaa 54780 accccatctc tactaaaaat acaaaaaatt agccaggcgt ggtggcgcat gcctatagtc 54840 ccacgtactc aggaggctga ggcaggagaa ttgcttgaac ccaggaagtt gaggttgcag 54900 tgagccaaga tggcgccact gcactccagc ccgggcaaca gtgagactct gtctcaaaaa 54960 aaaaaaaaaa aaaaaagaag aagaagaaga gattaggaca ccgggacaca aagagggatg 55020 gccatgtgaa gacgtgcgga ggaagacgac catatataaa cctcaggaaa aaacctacct 55080 ccaaacacca tgatctctaa cttctagcct ccagaactgt gagaagcaaa tttctgttgc 55140 taagatccag agtctgtggt ctttcactat ggcagcccag accaactaag acaccatctc 55200 tagtcctgaa atcgtgagga agcagcactc cccaagtcaa tctacattca gtgagctgtg 55260 gggaaatgga ctgcagtgct gagcttcacg gcctgagtcc ctaaggttgg gatgaagaca 55320 atgtgaggag agtcactttg atttatagct ccaacaatta tgaagcctct taggaatagg 55380 gcaagaaagc attttactgt gtctcgactc caagaactat aatgacatct tttaaaattt 55440 cattattctt tttgtttttt tgagacggtg tctctctctg tcgcccaggc tggagtgcag 55500 tggcgcaatc tcggctcact gcaagctcca cctcctgggt tcacgccatt cccgcctcag 55560 cctcccgagt agctgggact acaggcgccc gccagcacgc ccggctaatt tttttgtatt 55620 tttagtacag acggggtttc accgtgttag ccaggatggt ctcgatctcc tgacctcgtg 55680 atccgcccgc ctcagcctcc caaagtgctg ggattacagg cgtgaaccac tgcgcctggc 55740 cttaaaattt cattattcta tttacaatat aaatagcaat actaagccaa cgtaagcgga 55800 tattgtcagt gttgcacgct ttattagagc ttcttggaag atagacataa acacaacctg 55860 ccatccagcc gtgtccacgt gatggcttgg agaggctttt gcttcagcag ccagtcagta 55920 ctaagcatat ttctttttct tttctttttt tttttttgag atgaagtctc gctttgttgc 55980 ccagtctgga gtacctctgc ctcctgggtt caagcgattc tcctgcctta gcctcctgag 56040 tagctgagat tacaggcagg tgccaccttg cccggctaat tttttttatt tttattttta 56100 gtagagatgg ggttttacca tgttggccag ggtggtctta aactcctgac ctcaggtgaa 56160 ccacccacct cagcttccca aagtgctggg attacaggca tgagccactg cacctggccg 56220 attgaatgta tttttctatg aagacctttt ccctgtttta tgaagcatca actgtgcatt 56280 ctgggtggaa taacaaatct gagtggaata cttactattt acttgttatg tgcttcctag 56340 aacatgttac aaattcttat ttattttttg tgctgtatgc tatagcatcc caaacatctg 56400 tgatgctgtg ttacactaga gacaacattc tcaggcttgc atgcacactc acatacacat 56460 gtgcacacac accctcataa cacacaatta ctccctccac aagtcaatca accaatcatt 56520 tatacaactt catcccatag agtgttcttt aaatttcaag cccatgaagg atggtgaatt 56580 ctcaaagcaa tttcattgca gagggcaaaa cgagctgtca gaactagtat aggttctatt 56640 aagggtaaga taaagtaaac tctaatcagg gccagtaaga aaaagctaac tacgagaagc 56700 ttgagaaaga taaacgtttg cctggccaac acggcgaaac cccgtctcta ctaaaaatac 56760 aaaaattagc tgggtgtgac ggagcacacc tgtaatccca gctactcgag gggctgaggt 56820 aggagaattg cttgaacccg ggaggtggag gttgcagtga gccgagattg cgccactgca 56880 ctccagcctg ggagacagag cgagactcca tctaaaaaaa aaaaaaaaaa aaagaaagaa 56940 agaaaaacgt ttgcatccta gggggctatt taaccaaaag gtgtatggct cctgtgagct 57000 ccagatagtg gcttgtgaac ctctgatatt agaaaggata agaaatcatc cgtttctgta 57060 ctgagcctca aagagaagac tcagccctag ttaggaaata caaacaagac ctatttccgc 57120 taaattggca aagccaccaa tcagagccat atagactttg tgtggtcaag cttcccacca 57180 ctgatttcat gactcctaac ggtagaattc tgtcctgtga ggctgagaat gaacatctaa 57240 ctttaagaaa tacagcagag gccgggcacg gtggctcacg cctgtaatcc cagcactttg 57300 ggaggccgag gcaggcggat cacgaggtca ggagatcgag accatcctgg ctaacacggt 57360 gaaaccccgt ctctactaaa agtacaaaaa attagctggg cggggtggtg ggcacctgta 57420 gtcccagcta ctggggaggc tgaggcagga gaatggcgtg aacccgggag gcggagcttg 57480 cagtgagcca acatggtgcc actgcactcc agcctgggca acagtgcaag actccatctc 57540 aaaaaaaaaa aaaaaaaaaa tcaatctact ccttgcatca tgtgtgacat tttaattacc 57600 taggcagctt atcaggacat aatgaagcag ctgctatgat tatagaattt tgtcccaatt 57660 atttacaaag ctgctcagct acagaaatgt ctcattgtca tatccagcat gcttaggttc 57720 tagagcaggt gttaagcctg atttactggc caaatcagaa aattattcca tggccgtcac 57780 tttttctttg gagccaaaag attaaaattt aagttattct ctgaaagtgt gatttttttt 57840 ttttttaatc ttgattgtct tcttccggct atcagctatc tttcctcgtc gtcctgaagg 57900 tcttaatgtt tccctggttt cattctctgt cttcttggtg ttatcaaact ctgctctatc 57960 ggcacccttc caacaggtga gtatgcaata ttctgattct cccaaaggat aagatgaagc 58020 gtttgtagca aaatgctttt cacagacccc tagtaatact tttttccaag cataatgaat 58080 accgactatg cgccaggcaa tgagataaaa atactcatat ttttttctag taggaattct 58140 aaaattagat tctgattgct aagcagaaaa cagttctttt aaggctacct ctaaattgtg 58200 gtgctatatg gttgctgaaa tccataaaac agtataaaaa ggtcaactgt taaattaatc 58260 tttgtgattg attattgctg tccttgcaat aatctggttt aagttagaag ttgcattgtg 58320 gctttagttt taaatcgtca cagaatccct tccatatgct tttacagaaa agagagtatg 58380 atattttaaa agaagttcac atggaacatt ctctagggag gtagacatat tgtgtgggcc 58440 taaatggatg aatttacagg atgctggaac ttggagaaag tggtcaaaag tagctatcac 58500 tgcaagttac ctaacattac taccttgagg ccggggaagt tggagataag aatgagtgct 58560 tccaaataaa aagcagatgg aagaaaggga cctatatgga taagagatga atgagtttct 58620 actgaggagg ccatgcttat gttcccattg tgactgggat ggctgagata cagtacttcc 58680 tctagtgaag gtataaaaca aaagttattt ttctcattaa aaaaaagtta cactttaaca 58740 caaaggggaa ccaaatttac ttacaaacaa aacaagtaag gatagacagg gtcacacccc 58800 catggcctga atttgcataa tgttgtcctt ttagattaag aagaaatgtg tgctgatgaa 58860 ttgttcattt ttattcagag cacagaaatc tagtttcaga aaagaagtgt aggtctactt 58920 gagtcataat gttttcttat tgaataacat gcattcattt cagaactaaa tgcatttagt 58980 ttattgggaa taatgaagta attcttggaa gagggcgagg aaagtggaca gcatgtttta 59040 ttctggtgtt gatttgcttg gatgttccac agacagtcca agctttttgt aggtcagaga 59100 aacatcctta acctggggca aactttgaca cccagcagat gccttcaatc ctctttatct 59160 atcatagtgt ctgtttttct gtggtctctt ttactacttc aggtttgcta ttaatgatta 59220 tttgaactca tttcctcagt atacaattgg gggaggagtg gagaagatta atgtcatagt 59280 gtcatttttt ccctgtattt tgtgggtctg acctcgaatt ctgatcctta tactctctta 59340 agtttataca tggatagaat gttgtatcag aatgtactta taatggttgc ctttactaag 59400 agtatattaa ttatgggttg agcttataat taattgactt catgattgta aaagtgaagg 59460 gcctggtatt acaccgaact gcttcttagc acaaagtagg aactcaatat atatgagtgg 59520 aatggatgaa taaaagtgag tataaataaa ccatgactgc taagatgaac cactgttcaa 59580 ttgtaaacaa tgcaagataa cccaatcgtt ttgacattat gagggacgtg catcttttct 59640 tgagaaatgg ggtgagacat taagtcaggg gcctgatatg aggaagtggt agattcattt 59700 gtaccagctg tttagtgaca atgagaagag attacagaag tccagtgtgt ctagactagg 59760 ccacatgtga tttttatctt aaatctgata gtggcatgcc agttaggaca catcattcgg 59820 caagatgtaa ttgatatctc aggtctggga aaaaacctta aattgttttg tgctcttctg 59880 agtggctagt atgcaagccc gcacatttaa gattgacatc acttttgagg gtgtttctgc 59940 ccctgagtag ggacctgcca catggtggca aatgtgtttc tgtgaaatac tttcccagcc 60000 tgtatttcat ggactagtcc taggtggtct ttgcaaaata gaaaaaagct gtgtccatgt 60060 tcaatgattc aatgtattta gaaaattgcc atacgtttca aatcgagccc ttgggctttg 60120 gaatcaggca gggctgggtt cccagttggc aagtttgcaa actgtgtcat cctgggaaag 60180 taacttagcc tctctgagtt tcagattcgt aatatgaaaa ataagaataa taacaccaaa 60240 ttttggggac tgactgatga ttaaacagga ttccatatcc atatcatatt taagcaattt 60300 tagtggtagc ctatagtaac taaactataa atattagtga ttacgaccat tattatgatt 60360 agtattggtt tctttctctt gggtatttaa aatagacata aggaactctg acgaatccca 60420 aggtgaagaa gtcactgact tgccttaacc agcagtttct cactctattt gaccaaaggt 60480 ctggcttttt cacttagcat gaagatgcca tgtcccctgc agcacctttt gagaaaacat 60540 ctaagtgcac tacttctcaa aattcagtgt cccttcaagt ctcctgggtg tctcgttaaa 60600 ctgaagattc tgattgatta ggtccaggtg ggctcaagac tgtttctaaa aagctcccgt 60660 gtgctgctga tgctgctggt tcgtggacct cattataggt agcaaggact gggagcccgt 60720 gactatggta cctgcatgtc tgaagtttat atgtggatga tttctttctt tctctttctt 60780 cctttcttcc tttctttctc cctctttctt tcttccttcc ttccttcctt tttttctttc 60840 tttccttcct tccttccttc tttctttgtt ttgttttgag actgagtttc gctcttgttg 60900 cccaggctgg agtacaatgg cacgatctca gctcaccaca acctccgcct cccaggttca 60960 agcaattctc ctgcctcagc ctcccaagta gctgggatta caggtgccca ccaccatgcc 61020 tggctaattt tgtatttttg gtagagacag ggtttctcca tgttggtcag gctggcctgg 61080 aactcctgac ctcaggtgat ctgcccacct cggcctccca aagtgctggg attacaggca 61140 tgagccactg tgtccggcca gatgatttct tttagatgag ataattgcat atcagcatta 61200 gggaaaaaat accatctcaa tggaaaatga tgatgggagt atgtggaaag gaaagaaact 61260 agtagtctac cattttatgt gggtctgtct ctacccttct ggactgtaaa ttctctgagg 61320 aggcagatgt gttggtttcc tcactgctct atcccaatgc ccatggcttt tcttggcata 61380 gcatagacag atacatacat attaaatgac tgaatgaatg aataaatgaa tgaatgaacg 61440 acaggacacc gagtcttttc atcctgggag tcccattaca tgccacatcc cagaggttgg 61500 cgggaagcca tactgtggta actgaaagat atgtacaaga ttaggattta ggcagcatac 61560 gaaagcctta cttttatgct ttatttattg aaagtactct ctattttttg ttaaaagtct 61620 gtactgctat tctcctgata agtgtattgg ccagtgaggc cttcctgccc ttattttagg 61680 aaacttcagg agcacctttt ccatggtggg accacaaagg cagttttcca tcagagtaat 61740 tccacagtga gctcaaggaa gggtacaagg atggattgaa taatttctct tacagctcct 61800 gaagctctct acaagggagt attttcttat tagtgttatc acagctcctg gaggataata 61860 gacaatcaac tgaggaggtc ctcaaatgag atttctcaca gatttgctca tcagtgtggt 61920 gcaggttcat agctttaaat ctcaccaaag atagtttatg tttgtggctc aatgcaaatt 61980 gttttgccca catctaaatt tatttccatt ttatttgtat tggtctctac ttctaaaaag 62040 cttttagtgc agaatcatcg agttgacttg gaagttatct ttctgtgcat ttagacttta 62100 tgaattagaa gactaaatgg tatattttaa atggatataa aaaatcaaat gaataaaata 62160 ggccataatt cagctttgtt tagaatgaat attgtctcag ttcacttggg ctactataac 62220 agaatgtcac acctgtgtgc ttctcaaaaa ccaacattct ccccccacag tactggaggc 62280 tgaaagtcta acattaaagc agcagaaggt tcggcatctg gttagggcct gcttcctggt 62340 tcgtagatgg tcatctcctc cctgtatttt ctcacagtgg aaaggaaaca agagcactct 62400 ctggagtcaa ttctatcagg gtactaatcc cattcctgag ggcttccatg aattaatcac 62460 ctcccaaagg ctccatctct gaataacatc acattggggg ttaggatatc aacaatgaac 62520 tttggggagg cacagatatt cggcccattg caaatatatt tgtgcaaagg agattctaat 62580 aaatgttgac ttgtttctgt atgttaatcc aaagcacgtt gtattagtcc gttttcacac 62640 tgctgataaa gacatacctg agactgggta gtttataaga aaaaagaggt ttaatagact 62700 catagttcca tgtggctggg gaggcctcac aatcatggtg gaaggtgaaa ggcacgcctt 62760 acacggcagc agacaagaaa gaatcagagc ctagcgaaag gggtaacccc ttataaaacc 62820 atgagatctt gtaagactta ttcaccacca tgagaacagt ataggggaaa ccgcccccat 62880 gattcaatta cctcccactg ggtttctccc ataacacatg gggattatta caattcaagg 62940 tgagatttgg gtggggacac agagcagaac catatcacat gtttttgtat attctctaat 63000 aaaatgaata ataaatagtt ataaatatat aaaaatattt atatattttt gtatatattt 63060 ataaataaaa taataaaaga tgagttattt tataaatttg ttttaaaaga aaattttctt 63120 ttaaaatatt ttcttttctc caaaaatatt gcatacctat tagattatat acagaagcaa 63180 atttgacctt tccaattttt taaaggtctg tatgtgaaga aagagaagaa tgcgattttt 63240 taggctactt tgagctatgc tccccagagt tctttaggaa gcaatggatt cttcaaattg 63300 ggcatcctta aagcatcaca gtcatttgcc ttcaacaatg cagtgctcat ggacatatga 63360 aagacatttt aatgcagttt tacatgtgac aagttgaaag cgtcttccaa gagttccacc 63420 acactggtgc tgtccactcc attgctcggg attctttgca gtgatttttg agaggtgtgg 63480 gccttttcct ctttatgtgt cacgtgactc cacagatgcc tttcctgtgt cacccgcagc 63540 agatattact ttcccaatta aagtcctttt aaagaatggc ttttctccaa aagtggaact 63600 gaggcctttt agtggtttct tgctattttt gacacacata catgtatgca tgcacacaca 63660 cacacgcaca cacacgtaca cacacatgca gatagtagca ggtttaaagc tacacattcc 63720 acatcaattt ctccccatcc ctggcttcca agtgcacggt ttggtattgc tgtctgtgtt 63780 acacaggtta ttgctgcaat cccatgtgcc ggtgctggtc aacactgaag agctgtgccc 63840 gcacctcatc tattgtaaat cagtgccagc cttagggtaa attaccttcc tggagtgaga 63900 actgtaacct gctaatgctg ctatgtaaca gtctcagcaa tgtctgactc cttcttcgga 63960 atgttgttat tgaattaggt gttatccaat gtccactttt acactctccc ttctctcttt 64020 tctgtaaaga atttggttgc attgtttgtc tcaaggatga agaaaaatac caataaatac 64080 caccagcaac ctcccctggc aggttcagga cataagctcc ataatctgaa tttccctcct 64140 atgtttcatg aaggtagatg atgtaatccc tatgtgatcc gcctcagggc agtcatgtta 64200 aagtgtgacc cacctgaatt ctcaactaaa atttaccata caaaaataag tggaaggtca 64260 cttgcattac ggagaagcaa ttcttaatat gacacttatt tatttaataa gtacagactg 64320 aatcccagct atgtacaaag cagaaagtga ttttttttta tttattttat atttatttat 64380 tttttagaca gggtctcact ctatggacca ggctggagtg cagtggtgtg atcatgcctc 64440 cctgcaacct caacctcctg tactcaaatg atccttccac ttcagcttcc cgagtagctg 64500 agtctacagg tgcatgccac catgccctgg ctaatttttt gcattctttg tagagatggg 64560 acttcaccgc attgcccaga ctagtctcaa acttctgggc tcaagcgatc ctcccgcctc 64620 ggcctcccaa catgctggga tttcaggctt gagccactgc gcccaaccag gaggtaattt 64680 taaaactcac aagccacact tcctttctgt gagaagtttg taatttagga tgaaaactaa 64740 gatgcttagg ctaataatta aaatgaaagc ccattaccga ttcaaagtaa aatagaagtt 64800 aagaaaggca gaggccactt atggtcagtt ggttaggaaa tagttgctgg acgtgatacc 64860 attggagttg ggcttggaga gtggggctta atttctggca ggactagaag agaaggtttt 64920 tttttttgtt gttttttgtt tttgagatgg agtctcgctc tgtcgcccag gctggagtgc 64980 agtggcgtga tctcggctca ctgcaagctc cgcctcccgg gttcacgcca ttctcctgcc 65040 tcagcctccc gagtagttgg tactgcaggc gcccgccatt gcgcctggct aatttttttt 65100 ttcttttttt tttttttttt tgtattttta gtagagatgg ggtttcatcg tgttagccag 65160 gatggtctcg atctcttgac ctcgtgatcc gcccacctcg gcctcccaaa gtgctgggat 65220 tacaggcgtg agccaccgcg cccagccaag agaaggtatt taaagtagag gaaaatggga 65280 agaagatgca gtagcttgac catttaatga tgaaacctag tgcagtttgg ctacagaatg 65340 taagtaggac atagctgagg tctgttgaga agcaataatg gcctgggttg gggtggtttc 65400 tatggaaatg caaagaaaag ttaattagct cacagcgtga gcttagtaca ttcatctctc 65460 tgtatgtgtg ggggattggt ttcgggaccc ccaagtatac caaaatccag gcatactcaa 65520 gttcagaagt cagccctata taacctgcat ataaaaaaag gttgtatact tcagttttcc 65580 atccctcaaa tactgcatta tcaagctacg tgtggttgaa aacaaatctg tgtctaagtg 65640 gacttgtgta cttgaaatcc gcattgttca gagagtcaat tgtatgtaca ttggaagagt 65700 gattgcagta atgaatgcta tttactaatc tgatgttctg ccgttctata tgctggaaag 65760 taaacacatg ataaaattta aaatgtacaa aatgggccag gcacggtggc tcatgcttgt 65820 aatcccagca cttggggagg ccaaggtggg cagatcactt gaggccagga gtttgagacc 65880 agcctggcca acatggtgaa accccatctc tactattttt agtagagatg ttaaaaaatt 65940 acccgggcat ggtggcacgc tcctgtaatc ccagctactc tggaggctga ggtgggagaa 66000 ttgcttgaac cccggaggtg gaggttacag tgagccaaga ttgtgccact gcactccagc 66060 ctgggtgaca gggtgggact ccgtctcaag aaaaaaaaaa atgttactat taataattca 66120 agagatacat gttaaacatc ttgttttgat tttgtggaat ttaactacat caatcgcctg 66180 aaatatggcc acagaaatat tctagtatta taccatattt agtgtacata aacaattcaa 66240 gtactagtct gctagggtcc cataacaaag tacttcagac tagtggcttc aacaacagaa 66300 atttattttc tcacaaacct ggaagctgga tttctgagac caaggtgtca gcgaagctgg 66360 actctcctga ggccattctc tgtgtgtctt tataggccca cccctctaca tgttcctgca 66420 tcctcatctc ttctttttgt aaggacacca gtcagattgg aacaggaccc acccatatga 66480 cttcgtttta ccttaaatac ccctttaaag accctatctc caaacacagt cacattctga 66540 gcaactgggg attagaaatt caacacatga attttgtggg gacacatttc agccggtaac 66600 actccacaca cttgactttt caagtttctt ataatatttt tagttcataa ataggataac 66660 aggagatata tatatatata tatatatata cacacacaca cacacacaca cacacgttta 66720 tatttggaaa taggtgaggc acaaaattat aaatggtaag taaaatactg aaacccaagt 66780 cacctttaca aagtttaggt ggccaagagg ttgcatgtca gtttctagag cctcatcatg 66840 ccagtatgca ggtgggtggt cccttagctt ctgatagaaa gaacatgggc tctggaactt 66900 tgtttggaaa gaacacgtgc ttcagcacaa cttgcattta aggccagatt ctgctattta 66960 caagcagtgt gacttgtctg gctctgcttc cttgacattc aaatggagac gatgacatct 67020 acatctgcga ttgttataat tgagaagatg catgtagaaa gccctaggct cctaactctg 67080 cttgtaaagg tgagattcct acatggtgtg aatgaggaca cacttctgaa tttgatctgt 67140 acatcaggtg tctgtttttt ccttcccatg gatatagctg tatatataaa tcttagttgt 67200 cttttttaaa gaaaacccaa gctccttacc atctggtctc tgcacacctt ccttacccca 67260 cccagccctc tgctcactat gcagtggcca catgggcatt tttctattcc ttggtgatac 67320 ccaggtaatt ccacttcagg ctctttacac tgccatccct ttgccaggcc cggctgtccc 67380 tccaggtcac tcaagtcctg gctaagggtc cttcacttac tatgtattct gaagtcacct 67440 cccatcaact cacctatttt attttcctct taacttttta tcatataaaa ttatttattg 67500 atttgctttt tataccattt gtcttcctca cctttcccca ctggaatggc agatccatga 67560 ggacagcagc ttcgcctctc ttattcccta ttgtaaactg gaatagtgcc tgaatttgat 67620 acgcatgcaa tgagtacttt tacaagaaaa tgttataaat gtgtaacagc attgaagggt 67680 ataaacttcc ttcagataaa tttggcaata catattaaaa attaatactg acgtctgaac 67740 caaaatttct cttcgtcaga atccattcca tgaaatgatt gaggaagttt ttaaaaagtt 67800 taagtgtgtt tatcatcagt cagtcaggct atggtaataa catcctaata gcccgtcttg 67860 cctctctcta ctctccttct ttcatacttc agcccaaaat acctttcatt cccattttta 67920 aaaatacacc aaaatgatca aggttaaaaa gtcaaaagtc taatatagta gaaaacaata 67980 gttagctatt ccatcttttc tgagcccttc catgggcagg attattcaaa cacaagttta 68040 gtctactcac actctttttt tttttttttt tttttttttt tctgtttttg agatggagtt 68100 tcgctcttgt tgcccaggct ggagtgcaat ggcacgatgt cagctcaccg caacctctgc 68160 ctcccgaatt caagtgattc tcctgcctca gcctaccgag tagctgggat tacaggcatg 68220 caccatcatg cctggataat tttgcatttt tagtagagat gggttttctc cattttggtc 68280 aggttggtct caaacccccg acctcagatg atccaccctc cttggcctcc caaagtgctg 68340 ggattacagg catgagccac catgcccggc ccacattctt tatgattttt gatatactga 68400 acttcttttc acaccttact tttgacttct atttgtcaca ctttatcatc cttatacatc 68460 cttctttctt tgtttaataa gtttttcttt tttactttta ctgtacttac ttagaatgta 68520 tatattctat ttccatttat ttagatgtta ccttggaaat ttaccatgta catttaaatt 68580 agcaaaagtc tgcaattaag caataaccta agcaccttct tccatgaaaa gcaaacaaaa 68640 aacaaaagca ggttttggag cattttgatt ctgaacactc acctcaaaac ctacatgctt 68700 ctgggccagg cacggtggct gggtgacaga gcaggactcc gtctcaaaaa caaagaaaca 68760 atcaaacaaa acttacatgc tcctgttgtt ttctctactt ctatatattt attttttttt 68820 aacccagata ctaggtatta ttttattatt agcttattca gatgttattt ctttggattt 68880 gcttactgtt ttataatttc atttgttcat tcttacttgg atcccaaacc atctttttaa 68940 ggtcgtgttc ctttttcttg aagcatatcc tttagaattt tctttatttc aggtttcttt 69000 gtggcatacc ctctcagttt ttgttatctt tacccatcct tgttttatct ttttcataaa 69060 agagtatttg gctgggcaca caattctgta ctgactatat attttccctt tgtactttgg 69120 aggtaaaata tcattatctt ctagctttca ttagtgctgt tggaaagtct gaagtcattt 69180 aaattgtttc ctttttgtag gctgtttgtc cttgctctat ggcttcattt aagatctcct 69240 ctttgttttt gatgttctgt aattttgtca aagtgtgttt ggacacaaat ttctttttat 69300 atattctgat tttatttatc tcagtatatt gtacttttgg gatttttaat acatattttc 69360 tgatagttct aaaaattgta tctttttaat gattttcttt tatattcctg agattccagt 69420 tagttatcta tttagtcttc tcattctgta ttttatttat cttagtgtct ctttcacatt 69480 cttcatcaca attctatttt tgtcttacaa atagattatc tcctggaatt cttaatgatg 69540 atgatgatga ttattttcgt tttctcccgt tttctgaatt gtgtttcatc caacgtttgt 69600 atttttatat ttgttgcctt ggtcttcctc cttcatgatg caagcattcc ttgaatatct 69660 gatggctgtt gatttccatt tatattaaag attgagcaga taggaaggaa acttatataa 69720 gtgggcaagg gttatggaat agtctttgtt gctttatgat gtgctgttgt ctgaaggttt 69780 tcggctccca ccaaatttat atgttgtaac ctaatcccca atgtgatggt agtaaaaggt 69840 gcagtctttg agaggtgatt aggtcataag tgtggagctc tcatcagtgg aattcgagcc 69900 cttataaaag aagcccaagg gagctcattg gccccttcca tcatctaggg acacagcatg 69960 aaggcgccaa ctatgagcaa tgaaccctca ccagacactg aacctgccag tgccttgatc 70020 ttagacttct tggcctccag aactgtgaga aatacatgtt gtttataagt catccagtct 70080 atggtatttt tgtgaaagca gtccagcaga ctaagatata gtgagagaga tcggtgcttc 70140 agaatctgct gacatctttt ggttgctgac agcttttcct gttttctttg ccataatgat 70200 tttccctctt ttcttagctc attactctta ttttaaggaa gcttaaaggg aatatcaata 70260 gctcattcta ccatcttgaa ttaaaagcca catgtaattt tttaagaaga acactctcat 70320 tatattaatc tcttgcttga aatatgctcc ttgctgccca ttgctcatag aacaaagacc 70380 aggatcctta cgttggtccc caaggccctg aacagccttc tccccagaga atttccacct 70440 tcaccttaaa tcatgctcca tctggctttc tgtgctcttt tctcttctgc tagtccacaa 70500 tgactcctcc tgtctaaggg atgtgcacac atcatatgct ctctgtctgc agggcctttc 70560 tccttcctct ggccctcaca acccctgctc cacaactgca acctcctaat agatcaattt 70620 accctcttgt attatctcag agcatcagag atcttctttg tagtacttat caaagttgtg 70680 atttttcttt catttctatg actatttgat taaatctgtc tcatccgcaa atagaagtgg 70740 gcagctgatc ataatcctga aagacacagt acctagaaca ccataatctt gaatgttgaa 70800 atcctagaaa gtcaaaattt gcaaagtcta aaatcctgaa aataacaaca ctgaaagatc 70860 aaatccccaa attataattc tggaagaaat aatataaaaa attatattag aggtatttat 70920 ttatattttt aaagggggat ttattggaaa aacataaaaa catcatcgag aaacatgata 70980 ggccacttta cacaataaaa taagcaataa taacataaat atttttgcaa gcataaacac 71040 tcaggtatac taatgatagt cacatgagca taacagttag gaacagacag cacatattca 71100 taaagaaaca ggctaaaaag ggaaatgtat aaattcacat cactatggtt ggttattgtg 71160 tgcacccagc tttctaacta cagtcgtctg aaataccatg atgaacaacc ttagtctttt 71220 gacgagtcaa tcaaaactgc aaaggttcgc caccgcattt gcaatcgccc aaagaaccaa 71280 gatctccaga aattgcatct ttcacagata caaatgtaca aaaaggacat ctcttcattt 71340 attgaggaag ttccaatgtt tatactttga gaaccaggga tgccgacgat gtgtctctca 71400 gtccaaggtt gaaaacctca ggatcctggg agctgctggt gtaagttcct agagtccaaa 71460 ggttggcgaa cctagagttc tgatgtccaa ggcagcagaa gaaacatctg tcccagctct 71520 cagagagagg gatctgtgcc tcagaatccg ttgtaagctt ttgttgctga cagctttttc 71580 caatttgcct tctgtatttg ttctttcctg gtgcccagcg aattggatgg tgcacctgac 71640 aacatggaag gcaaatcttc ctcacttagt ccacccagat tcatacggta acctcttctg 71700 gaaataccct cacagacaca ctcaaaataa tactttacca ggtttctagg tattccttca 71760 gttcttaatc aagttaacac ctaacattaa gtccactggt gaccacatta agtcactact 71820 ggtcaacgtg ggtaacttgg cacccatatt cctcgcctta aaccatgctt aataacaaga 71880 tggctagatc tgcctaacat gatgcaacta ttttctgata gtgattttca agattttaga 71940 tattagggat tttaggcttt agggatttga actttgagat ttttggtctt tagggatttc 72000 aatctttcag gatttcaatt tttgggatca tggcatttgt gattgtgtct tttgggatta 72060 tgatacaaac ccaacaaggg gtcagattgg gtttgaaaat gagcaaaatt attttgtaaa 72120 aattataatt atatgttata taattattac ataataattt tgctcatttt cattccttag 72180 tctccatgta gtgaatgaat gcataactga atgagagatg aataatagca gtaaaggacc 72240 ttggatggtt tatcttatgc tattttttga ggatattcag gagatctttg ttgaatctgt 72300 tccatgatca tggtaagatg tttaagctga atctcagact caccgagata gaagtaagtg 72360 atgatgaagt aagtgataga actaagtgat gatgaatgtg gcttccagta tgaacatgac 72420 ttatttatgt ctaataatgt gttccatttg tacagaactt taggcttttt aatatagttt 72480 cacatattca gattaatttt atcttcatat ttttatgaga cattttgttg gttcatttag 72540 atgaactgga ataagactga ctcatgtctc tgcaggttat gagacacatt tagaaacgaa 72600 gatgctagga tcatcaacca catggccagg caacaaagaa ggaaaggaac tgtcactcat 72660 gtgtaccttt ccgaaagtgg agcctggaag gctgtttgag ctcccaggca gtctggagcc 72720 catgctgttc cattgctcct tcatgtacaa cccacggagc ttcacctgac cattaacttc 72780 actcagtttg attcccagca caccagcctc tgtctatgtc tctctcacat cactttccac 72840 tatgaattat gcttgttctt cccctctatc acttctatgc tctttcactc tacatctttt 72900 attaaaatct cagagagaga gaaaaaagat tggtcttagg gcagaactct catagtaact 72960 aagtcacagg ccgcctgtcc tgtatgatgt ggtgtgcaaa gcactgttgt cttaaagtgc 73020 tctggaagct cccttctggt tgttggacag catctcagct agcacttccc cttgttccca 73080 gtggggaagc ctcaacccaa tttcagcttc ccatgggacc aatatcttcc tttttcaggg 73140 taggggggat gcatctgaac ccagcttcta ctgtgtcttc aaggcttccg tattctgggg 73200 atctggactt tccaaacagt tgcttcaaac agctgacatc taaattcatc ctgcctggtg 73260 ccccggtagc tggattattc ccttacttac aagattgctc tcacacttgc cttgtttaaa 73320 gggcaggcag cctagcagag gggaacttcc cctagaattc acagccacac tgcctgccca 73380 ccacagtgtc ttggcccaaa tgcctttcta tggcatcaga gggaaaatca ggggcctgtg 73440 ctttcttttg cttacttacc ttggcttgta ggcactttgc tgaaatgtgt taggttggtg 73500 tagtgggttg aacagtgttt cccaaacatt cgtgttctcc tggtacctca gaatctgacc 73560 ttattttgaa atagagtatt tgcagatgta attaagttag gatctggaga tgagatcagc 73620 ctggacttac tataagccct aaatccaagg actggtgtcc ttctaagaga gaggagatgg 73680 aaatttagac atgaagacac agggagaaga aggccatgtg aagacggagg tagaaattgg 73740 agttgtgtgt ctacaagcca aagtatgcca aagattgctg gcagatacca gaagctaaga 73800 gaggcatggg aattaacact gcctacatct caattttgga ccaaatttct attgtttaaa 73860 gcaaccagac atgtggaagt ttgttatggc agccctcaga aatgtaaaca gctgggtttc 73920 ctagaagtag aacctgagaa gggggttctc gtgcgaggga ctgatgaagg attggttgaa 73980 caagggttag gtggggagct gcgtaagtca gggatgtggt ttcagctggg gactggcctc 74040 tgtctgacct cacaggctgg ctctggcgca cagagcgccc tgcagggata tgatccacct 74100 gtggcaatag ggccaatgct ttgaccccta ggtcagccag ttactgactg tgggctgctg 74160 ggagtgagca atgcctccag caggagctgc tttttatttg acagaagaca gctctccggg 74220 acagggtcca ccaccgcggc gattatggca atcgttattt cttaaggcaa atcctgtgaa 74280 gttatggaat ttgttacggg ccctggtcca taatggtggc agccacgaga ggacgtgatt 74340 tgcgtgagta acacccacaa agggaaccac gttgcacagc acagcagatg cccaccattc 74400 cggcagttat ctgtatttgg gaagggggag gttgtatgat acagagagga agagggaatt 74460 tggctgggga ggccaccaaa ccaagacagg cagttggaca tgggcagggc tcctgctgag 74520 ggaactaaga cagttcctaa aactgcctga gctctatgca gagccacccg cagcaggagg 74580 tataggacac aggtctgaca tgcctataac tgagaggaaa gagataggca ataaccatta 74640 aatcaggctg ggcacagtgg cttatgccta taatcccagc actttgggag gccaagatga 74700 gtggatcacc tgaggtcggg agttcgagac cagcctggcc aacatggtga aaccccgtct 74760 ctattaaaag tgcaaaaatt agccaggcac ggtgacgggt gcctgtaatc ccagctactc 74820 aggaagctga ggcaggaaaa tcgcttgcac ccaggaggtg gaggtagcaa tgaaccaaga 74880 tcacaccatt gcactccagc ctgggggaaa agagcaaatc tccatctcaa aaagaaaaaa 74940 acagaaacaa atcacttttt aaacctatta ctagcaaaac atttaaaaac agaagctaga 75000 agtatgtgtt gacacaatag cacattttat cagcccttat tatgaaaatt ctgtgtcaat 75060 tcccgtccac ctgactttga agttatcagc atgtgtagca aaagtgaata tgtttcatgg 75120 cctctttccc atgaacgtat tcacatttta tgaaataata aaattcgcat aaagattaca 75180 tcataaactc cagtctccat tttcccctct tcattgtatg cgacatacgc acgttccctg 75240 aaaataaaat gtgcgtgtaa aattaactgg ctattttagg ttgagttccc agtgtaccta 75300 tttggaatgc ctttccaagt caaaacaggt tttgaggctg taacaatagc atcacaaata 75360 aaacaagttg gattcagagt tttacctaaa gtaattggga gtaaaaaagg aattgttcaa 75420 ggttccccac tatatcttca tacttccttt cgctggctct tgatttactt agagatgcag 75480 ttaagatgga aatgagccat gcccagaggg atggagaagg cagagtgagt gagttccggt 75540 gttgctttta tgaaccacgc aagtgctctt tgcagaaacc tggtccggaa gccttccccc 75600 gtgtaggtgc ggagaggaga aattgctcac agtctgaagg aatagcatgc acaagaacac 75660 attttcaagg ggttctgctt tcaaaactcc acctttcggg aaaaatgtaa aaggtgcttt 75720 gagatgacct tcactcttgt ttattcccaa tactccctcc tccatccgtt tcaatcattg 75780 cagctcagaa ctgcgttatg acagcagcct gaagaggaac ccaggcctgc cttataggac 75840 acccagccca tggcctgctc aatgaaaata cctggtaaaa tgggcagcat ggttctatgc 75900 taatgaaagc tcgtgccctt aagtggcttt ctgtccctca tgtgggctgg gtggcctgtc 75960 tcccactgcg tgaagcctac agctctttac actgcccaac tctgtttctt ggtttagttt 76020 gactctgcag ctacccttgg gcatgccctg gagtccggca gcctgggggt gctatgccat 76080 gtccaggctg cctcgtgttt accatgatcc ccttggctgc tttctttctt tcattctaaa 76140 tctcctggaa gtttccagaa gaaaagactg ccaacttctc accttggcac cctttctacc 76200 tcttctgttt ttgcatttta cttttacttt caatatgcct ctgcatctgt ttagtaacaa 76260 ctaaaaagtt ttcctagcta ggttatgact atctcaggct ttgaagctct gttcttctta 76320 ccagccacat ggttagggct gcctaactaa cctttctgtg cctcagtttt tttcatctgg 76380 aagatgggga tcccataata acattcgcct cctgtagggt tgttgtgaca attaagtgag 76440 ttttcacaca aataaggttt agagctgcac ctggccattt gcaggtgctg agtgttagct 76500 gtagtttctt tttctacacc cccaactgtt ctgaaagacg gtaagggctg tgagccctga 76560 cttggccgtt atcagcaatt ttgacaatat tgcattcttt ttccatggaa aaaactcgaa 76620 taactcttac agatgagttt caaagtcaat acaagatcat cactgtattc tacagttcca 76680 gacttgggtg cagtattggt gcctaagctg gccaatttcc tagccattgg aggtgtgagt 76740 ctcacggcac tactttaata ctttgatgct gagatgccaa tagagaaaga aaatattgaa 76800 aagttgagaa actgattctg aatttggttt ttatattttg ataaaaatga agagaaacta 76860 aaagaattta aggagaccag tcttttaaga aatgttcaag tctacttttt gttttgtcta 76920 gggaagaaat gaagaccagt tatacagcaa ctcccttttg tttttaggaa gataattgga 76980 tataattttg agaatgttcc ttggtttaac ctcggggaag agttcagtgt tattgttaaa 77040 gaaaaaaaaa tgacctttga taaggcagta aggcagactt tattcagagc catagagacc 77100 ctgcaattgc attttgaagt gggcgagaga gattgggcac aattccaaat acaaaaaaca 77160 aatgggagtt tatagccagg tagtgaggtg gggatcagtg gatggaatat tatttacagg 77220 agacatcaag ggtaaggggc attctggcta catcacctga acatgactct tgctgaacac 77280 agaccagggt gatcagacaa ccacctgggg gttggtgaag gagaaacctg atcagatagt 77340 tagggtgatc agatacccag gatagccaaa ctaagcagga ttcttgctaa aactggagaa 77400 ggcagagaca agaaaaaatg ctccaaagtc agggcttagt tgagaagagc ttagagaggg 77460 gcctgcctaa agtctggtca gggaaagagt ctgtcgtgat acacagttaa gcacaagact 77520 cttggcagat gctatgagat ccacctctcc agggatggtt gaaggaggct ggcttggatt 77580 tgggactctc tgaaagggct ctcactgtga agacagcagg atgctgacaa tacccacctg 77640 tgtccaccac agcatgcagg cctcatctac ttctccaccc acctgtgtct gccacagcat 77700 gcaggcctca tctccttctc cccatgggtg cagcacagct ggccagcttt gaggttgggg 77760 tcatctgtgg gtctctgacc agagctccca cattccctaa atggaaaatg aaacctgaga 77820 attttctgtg ctgcaccatc tttgctagaa tacttggctc aggaccaact atcaagaata 77880 tgagagaaca agtagtgtat cacagagatg taagtgtcaa tccttgttct ggaatgttcc 77940 ctgcagtggg gattcagcac agatcatggc cacttatagc cttgggaagt gagagcagag 78000 ggttggggaa gggcccccat gagcctttca ggtctagact ctagtggatt aataggagca 78060 gacatcccca gctgccctct agagatagtt ctaatatttt agtcaccata ctacttcacc 78120 ctgacatcaa aggacgtctt caatatgcat ctctttgata atctcccctc ttgggtgaat 78180 ttcagcctgt ctcaattggg cctccacctt ccttttcaaa gaaaatgcct tgttttttcc 78240 tcttgttcta taagatcttc cataccccta tgctatatcc gaggtctggt gctcaacttc 78300 tgttctcagt aactactggc ttttgtttct aactttcact acaattacaa tcaacgcaag 78360 ctttgggaag cctgctttta ccttgaagca cttccacatc aggaggtctg agtgcagagg 78420 tgctccttac aacagatgga ttgctgcact taccggggaa aggccatcct gtgatgttca 78480 ccaaaactaa caaacacctg gaaatgggaa ttgtgtttaa tgaaaataaa ctgaagctgg 78540 cttcgttcat tatacccaaa atattagcca tctctaatct tttcctcaca ggttatgccc 78600 tgcaggaatt actgggaggg atagagaaga atgctttcgg ttagtgaaag acaagctgta 78660 attgttggga gcactggatg agaaaatgca cataaaatca cttggaaact tggattagca 78720 tgcaggacag ataggttctg aagctcttcc cagaattatc acactgcagc ccctcagggt 78780 gggggtgggg ggaggggtgt caccgtaagg taatgaggca ggtgggaagg ccacctgtct 78840 tggctcagag ccactggggt gccatctggg tgcaattcag gcagggggtg actggccacc 78900 tgtcctggct cagagccact ggggtgcaat ctgggtgcag ttcaggcagg ggtgaccatg 78960 ttttctttaa tgaagttata gcctatgcta tgtgaaatac ctggatgatt ccctaaaatc 79020 gactttaaca gtgtttgcct atattagtca actttagagt gttttataag tagttttcca 79080 cttaatcaca ttcattattc ttgatttttt ttctttttgt ccctgtcact gaacatttgc 79140 atatgtagac aaaataaaat gctgtatatc tcatagtgaa accatgtaac atgcacacac 79200 gcacacacac acagggagag agagaaagag agaaaatggt gagccatgta tcaatgatca 79260 taactgacta aactggcaat gttaaactac tgcgggttct acctctcaaa gatcctgaat 79320 gtcacaggtg gcaccatccg tagaaatggt aattcatccc gtcaattagc tgtgatgctc 79380 aggaccaaat gttagcaagg ctgggattaa tagcaagtga tcatttgcat ctggcattca 79440 attgggagct gccatgagat gctcccaccc tggggtctct gttctaaata tacgacaggc 79500 tgatactttg caggaaggtt cattctcaaa cataaatagc acacatggtc tttgcatttt 79560 gcctcccatc ctagctggag aagcttattt tgtatgtcat cctaaaggtc aactttctca 79620 cgctaaaaaa gaaaatgggc atcaggcgaa ggtgcaggga gcgcagagaa tgctcagtgc 79680 agcagctggt ggttgtcctg tacctgcttc gtgcttgtct gtgtgttttg cccaaagtga 79740 tgtgggcccg aagttactgc caggatctgt ctgtgcccta gttttgccca attctcacgt 79800 caccaattct acgaccctta tttcagattg aaattttttc atgtgagacc cactacctga 79860 agaaggcaac cctgcttact tactctagta ggaaaaggaa tgctggtttt ctcagagtga 79920 aactatttaa aatcttaccc cttatttttc caaacacacc cctcccacag tgctcctaac 79980 atgttttagt tgacaattaa acgtctttgt gaattagttt ttttgttccc tgttccacat 80040 ttcccctacc cataaggctt acgtatttcc tgtaaagcaa gtacccttct tttaaaacaa 80100 agaaccatga aattaagaaa ggttttttgg ctggacacgg tggctcatgc ctgtaatccc 80160 accactttgg gaggccaagg cgggtggatc acctgaggtc aggagttcga gatcagcctg 80220 gccaacatgg tgaaaccccg tctttactaa aaatataaaa attaggcatg gtggcatgca 80280 cctgtaattc cagctacttg ggaagctgag gcaggagaat cacttgaacc tgggaggcgg 80340 aggttgcagt gagctgagat tgcaccactg cactccagac tgaacaacag aaagagaccc 80400 tgcctcaaaa aaaaaaaaaa agttgttttt tttttttttt ttttggaatt gttgttttgt 80460 ctttttaaaa acattagtga tggtgaccaa aacttggaac ttggaagctg tcagttgggt 80520 gaggctttcc aggctgtgtt ttctccatct gatgctcttc tagcaagcat tttctttcag 80580 taaaactccc aggggaaaag aatgtgaaat aactactttg taaatgatac caagcctcaa 80640 tgttaatgtt cagtattgat attgaatgtc tctcagcatt ttagttagtt atgtgtcatc 80700 ttcccttagg tttaagaatg tcatatatca gctatcctgt taaggatatg tatttaatcc 80760 tttgaaaata tatatatata tacacacata ccaaatacat ataaaattga aaggctctgt 80820 tttatatttt tatgtatggg gaaaatgggg agaatttcaa cttactttgt aatcgggtcc 80880 taacagttca tgatttttaa taagtagcaa tcttaccagc agtgctttcc caccgtagat 80940 ttaattagtc tttcttcccc cacccccaac cccttttgct agttgacgga gctgagagga 81000 gggaaacggc cgcaatttga aaccttgtta gaaatttatg aagtgctaaa atgttttatt 81060 cccagaggct ggcttgccag ctgtcacgag ctccctgcct gcctccgcgg ctgtgatagc 81120 aggggtaaga gggaggctgc cagagctgca cagggtgggg aaatgccatt cccatcagca 81180 gcacagggcg gaggtcagct cctcgttctc ctgcagctga ccagccacat gtgagatgag 81240 aattcagggg atctggagcg ggcatcggag ccctagagta agaccctttg cggctgttga 81300 taacaggcac tgatcgctga tcatgcaatg agacgtcagc tttggttata gaaattaaac 81360 aaccattctg ttggtggcct caaacagata attggcctct tactagcaaa atgtccctga 81420 actaattttt tctggaggaa acaccttctc acaaatgtta ccaggtgtga aggatgttct 81480 tcccggggtc atagcctacc tgcaatgact ctctgtgtcc ccatccctcc cccattgctt 81540 ctatgatgcc tggaatgtgt ctctcaggaa acaaagttta aaaaaatttt ttttctttgg 81600 tccttgaatg gaaatatcac ttgcacactg tggtcataga taccccagag aataaacaat 81660 tcataataaa ggtgcaaatc acccacgtta gatgctgagc tggaggaagt gctaagtctg 81720 acatgatgga gaccaaaagg ccccacggaa gcagaggagg aggaggaagt gcctcctcca 81780 gggccagggg ctgggccagg cagtgccttc atgatttgcc tccaagttgc tctgcgcaag 81840 gaattgggca tggaagaagg agccagagac ctcagaaatc ttcatggcaa tgacattggt 81900 taggaaagta tgccctcagc accctctcct acttcctctg cctctccaaa ccaacaatta 81960 tagtaagtac ttttggttcc acagaacttt ctgacaagtt cttttttttt ttttctgtga 82020 tacatgtgca gaatgtgcag gtttgttaca taggtacaca tgtgccatgg tggtttgctg 82080 cacctatcaa cccatctcgg ttttaagccc tgcatgcatt gggcattttt cctaatgctc 82140 tccctctcct tgccctccac cccctgacag gccccggtgt gtgatgttcc cctctctgtg 82200 cccctgtgtt ctcattgttc aactcccact tgtgagtgag aacatgtggt gtttggtttt 82260 ctgttcctgt gttagtttgc tgaggatgat ggtttccagc ttcatccatg accttgcaaa 82320 ggacatgaac tcattcattt ttatggctgc atagtattcc atggtgtata tgtgccatat 82380 tttctttatc cagtctatca ttgatgggta tttgggttgg ttccaagtct ttgctattgt 82440 aaataatgca gcaataaaca tacatgtgca tgtgtcttta tagtagaatg atttctaatc 82500 ctttgggtat atacccagta atgggattgc tgggtcaaat ggtgtttctg gttctagatc 82560 cttgaggaat cgccacactg tcttccataa tggttgaact aatttacact cccaccaaca 82620 gtgtgaaagt gttcctattt ctctgcatcc tcaccagcgt ctgttgtttc cagacttctt 82680 aatgatcacc attctaactg gcttgagatg gtatctcatt gtgattttga tttgcatttc 82740 tctaatgacc agtgatgatg agcttttttt catttttttt tttttttggc ggcataaata 82800 tcttcttttg agaagtgtct gctaatatac ttgacccact ttttgatgga gttgtttgtt 82860 tttttcttgt aaatttgttt aagttccctg tagatcctgg atattagccc tttgtcggat 82920 gggtagattg caaaaaattt ctcccattct gtaggttgcc tgttcactct gataatagtt 82980 tcttttgctg agctgaagct ctttagttaa ttagattcca tttgtcaatt ttggcttttg 83040 ttgccattgc ttttggtgtt ttactcatga agtctttgcc catgccaatg tcctgaatga 83100 tattgcctag gttttctttt agggttttta tggttttagg ttttacatgt aagtctttaa 83160 tccatcttga gttaattttt atataaggtt taaggaagga gtccagtttc agttttctgc 83220 atatggctag ccagttttcc cagcaccatt tattaaatag ggaatccttt ccccattgct 83280 tgttcttgtc acgttttcca aagatcagat ggttgtagat gtgtgctgtt atttctgagg 83340 cctctgttct gttccattgg tctatatatc tgttttgata ccagaaccat gctgttttgg 83400 ttatggtaga cttgtagtat attttgaagg caggtagcat gatgcctcca gctttgttct 83460 ttttgtttag agttgtcttg gctacacagg ctcttttttg attccgtatg aaatttaaag 83520 tagttttctc tagttctgtg aagaaagtca atgttagctt gatgagaata gcatttaatc 83580 tataaattat tttgggcagt attgccattt tcataatatt gattcttcct atccatgagc 83640 atggaatgtt tttccatttg tttgtgtccc ctcttttttc tttgagcagt ggtttgtagt 83700 tctccttgaa gaggtcttat cgcatccctt gtaagttgta attccaggta ttttattctc 83760 tttgtagcaa ttgtgaatgg gagttcactc atgatttagt tctctgcttg tctattattg 83820 gtgtatagga gtgcttgtga tttttacaca ttgattttgt atcctgagac tttgttgaag 83880 ttgtttatca gcttaaggag ttttagggct gagatgatgg ggttttctaa atatacaatc 83940 atgtcgtctg cacacagaga caatctgact tcctctcttc ctatttgaat gccctttatt 84000 tatttctctt gcttgattgc tctggccaga acttccaatg ctatgttgaa tagcagtggt 84060 gagagagggc atccttgtct tgtgccagtt ttcaaaggga acgcttccag cttttgccca 84120 ttcagtatga tattggctat gggtttgtca taaacagctc ttattatttt gagatatgtt 84180 ccatcaagac ctagtttatt gagagttttt agcatgaagg tgttttgaat tttatcagtc 84240 cttttctgca tctgttgaga taatcatgta ttttttgtca ttggttctgt ttattgattt 84300 gtgtatgttg aatctgcctt gcatcccagg gatgaagctg acttgatcat ggtggataag 84360 ctttttgatg tgctgctgga ttcggtttgc cagtatttta ctgaggattt ttgcatcgat 84420 gttcatcagg gatatcggcc tgaaattttc ttttcttgtt gtgtctctgc caggttttgg 84480 aatcaggatg atgctggcct cataaaatga gttagggagg agtccctttt tttctattgt 84540 ttgaaataat ttcagaagga acagtatcag ctcctctttg tacctctggt agaatttggc 84600 tgtgaatccg tctggtcctg ggcttttttg gttggtagac tattgattta ctgcctcaat 84660 ttcagaactt gttattggtc tattcaggga ttcatcttct tccttgttta gtcttgggag 84720 ggtgtatgtg tccaggaatt tgtccatttc ttctagactt tctagtttat gtgtgtagag 84780 gtgtttatag tattctctta tggtagtttg tatttctgtg ggatcagtgg tgatatcccc 84840 tttatcattt ttttattgtg tctatttgat tctcctctct tttcttcttt attagtctat 84900 ctagtggtct atctattttg ttaatctttt caaaaaacca gctcctggat tcattaattt 84960 tttgaaggtg ttttcatgtg tctaactcct tcagttctgc tctgatctta gttatttctt 85020 gtcttctgct aggttttgaa ttcgtttgct cttgcttctc tagtttcttt aactgtgatg 85080 ttagggtgtt gattttactt ctttcccact ttctgatgta ggcatttagt gctatacatt 85140 tccctgtaaa cactgcctta gctgtgttcc agatattctg gtacactgta tctttgttct 85200 catgggtttc aaagaacttg gttatttctg ccttaatttt gttatttacc cagtagtcat 85260 tcaggagcag gttgttcagt ttgcatgtag ttgtgcggtt ttgatgctct acatgtttag 85320 agaaacttct ctagtaatga actatagaaa tgatccctga aagtactctt ctgataagtt 85380 cttttttaaa aaagtaaacg taccagggca ctctctaatt gggatcgttt ctctctgtat 85440 tagtttgtta gggctgttaa gaaagcatca caaactgaga ggcttgaaca agagaagttt 85500 gctctgtctt gcagttctgt aggctccaag tccaagatga aggtgtcaac agggttgttt 85560 tttttctgag agctgtgagg gaaagatctg ttccagtcct ctctccttag ctggtggatg 85620 tctgtattca tgatcacatg atgttctccc tgtagtacac atctgtgttc aaatataaga 85680 tgagagatgg aggggtggag gagagaaaaa aagagggagg gcgggaggga gagagagaga 85740 gatgctatgt tgttggcttt gaaaatagag ggggggccat gagccaggaa atacatgtag 85800 attctagaag ctagaaaaga taaggaaaca gactctctcc taaaaacatt tgataacagg 85860 taccgagctg ggagacttgg agcagataag agctgtactt agatttagca aaactgcatc 85920 ttcgtgatga gccagactca aggatgataa agtccactac ttggaaggat catggatgca 85980 gccttgggtt taacttgaag tcattcactg agttcagata ccagactgac tctttccata 86040 aggaattgcc tggttaggtg agggtagaaa ttcaacaatg actgttgcat tccagaagaa 86100 ggaaggcaaa gagccaaact ccaagttgtg ctttgggaat gttgtgatta taagtaagtg 86160 catcagctcc aggctcccca gtgtcacatg cacacactat ggggactgat cgtgttgatt 86220 ctcagtgagg tgtcttgggg accctgtccc agctgggaag gtagggatgt attagaaggc 86280 ttggtgccag gtgcagaaag gggaagattc tggaggccag gcacagtcca tgagctgtag 86340 ccagagatat ggcatgagaa taacatctaa cttcccagaa aaacagcaca gccaagccag 86400 gcatcagtca aggatcacag gaggagagat ttgcaggaaa gcaaggttcc tctacctggg 86460 tggcaaaatg ccacagctgc tgaggcttcc ttgactcttg cctgcttgaa actggcaaag 86520 cagtgactgc tggtggctat gaatgcttgt taaatggccc attcttactc cctgactggc 86580 ctgtgcccag gacctctgca gttggataga aagacagtgt ctctagggta aggcaggtca 86640 gaatcaaaca caaattccac tcagtatgac ctgtggctcc tgtgcaagct aacgtcaccc 86700 tctcagcctc agtttcatga tgtaaaaaac aggaggaatt ctgaaatatt tgaagcagct 86760 gtgaagcaag ggccaattga atcaataaat gtgaatgtgg ctgggcgtag tggctcctgc 86820 ctttaatccc agcactttgg gaggccatgg tgggcagatc atgaggtcaa gagattgaga 86880 caatcctggc caacgtggtg aaaccccgtc tctctctact aaaaacaata aaaatgaaaa 86940 aaaatttcaa aaattagctg ggtgtggtgg catgcacctg tagtcccagc tactcgggag 87000 gctgaggctg aagagttgct tgaacctggg gggtggaggt tgcagtgagc caagatcctg 87060 ccactgcatt ccagcctggt tgcagagcaa gactctgtct cataaataaa taaataaata 87120 aataaataaa taaataaata aataaataaa taaatgtaaa cgtatccaat acagctcctg 87180 attcttcatg gaggcaaaaa gatgaatgcc cctctcgtca cctccccctt ttgatgtgtg 87240 gagggcgatg gctgcatttt catctgggac agtgatggag atagaaggcg gcagtgagga 87300 aggaaaagga gggaagcaaa gactggcacc ccaggctgtg caatgactgc tgccaggggc 87360 aggctcatgg gatgatggca ggagggatgg ggagctggct ttgaagtcct ggactgaagc 87420 cagaatggtt ctcatgctcc cgtagcaagt gctccgaggc cagccccagc aatcaaccca 87480 actgagggca gcacagaaga gtctggacag cccactcccc gccgtattga tgtgcataat 87540 tagcctgcag gtgcaccttg actgggggac agagagatag gcaggccagc tggcaggctg 87600 cccccaggga tatgggtatt tatccatgat cagaagggca caagcgagtc acgtgcactt 87660 taaagatcat tcagttggtt tttttattca ggcttaaaaa gatgtaatcc agcctgaaaa 87720 gattccaggg gcaatgagga attcaaagca gagccggcta ttaggtgacc atgatgcttg 87780 gagaatgtgg gggcaaggag gagtcctgat gcatggggtc atggagagtg gtgggagtga 87840 gatgggcact caggataggc ttggagcacg tgggaggctg agagcctggg gactgtggaa 87900 tccaacctgg aatcctcttg gatggactgg gagactcaat gccaagagat gagacaggat 87960 gggactaaga gcaaaggccc caggctggga ggagctatgt gtcccttctc tctacccttc 88020 tctccctctc ctttttgtgc ctcctcacta ccccatttca caccccttcc aggcagcctt 88080 gtgcagtccg gatccctgta ctctaaggat tgtcacaagc atacttgcgt tctttattta 88140 tgatgatcta ttaacaagaa taaatggttg tgggtcagat aaagggctaa aaatcaaaag 88200 tcatccttaa catctttaag atgctactat gtatcatctg tcagggcatg agggtcttca 88260 tcaggcccac taaagaatcc catttctctt gaaccaagtg tgtcatgact gggaggaaga 88320 caagaccatt tggggtgtga agttttgggc tagaggccct tttaggagcc aggttagccc 88380 ccagcttccc caagaaacca agctgccccc ctcatcctcg cctaagcaag cagctgatga 88440 caaaaccgga gttggcctga ggggttcaaa ggaaaaccat aaatagaccc cccaaaataa 88500 gaaaatcatg taactaaatt ctttccactt tatgccagca gtcaccacac ctcctgtcct 88560 ctgtatctca gttttaggtc tttttttttt tttttttgag acagagtctt gctctgtcgc 88620 ccaggctgga gtgcagtggc accacctcgg ctcactgcaa gctccgtctc ccgggttcac 88680 gccattctcc tgcctcagcc tcccaagtag ctgggactac aggcgcctgc cacagtttta 88740 ggtctttatt ctgtgttcct ctttattttt ttcccagtcc ctttttctgc atctctcaga 88800 atatacacta atgtcctagg acagccgtaa caaagtgcca cacattgggt ggcctaaaac 88860 aggaggaatt tattttgcca tagttctaga ggccagaagt ctaaagtcaa ggtgtgagca 88920 cggtggtctc cctctgaagc tcctggtggg agtctgcttc gcctctctct gtggctgctg 88980 gtggctgcct tctcagtccc tgttgtcata tctatcatac cgtgttctcc ctgtgggtct 89040 gtgtctgcct ctctgggtct ttgtccagat tttcctcttc ttataagaaa accagtcatt 89100 gaattagaga tcattgtaat ccagtatgac ctcatcttaa tttgatgaca tctacaaagt 89160 tcttatttcc aaataaggtc acatccacgg gtactgggtg ttaggacttg aacttacctt 89220 ttagggggac acgattctgt ccactgtgat ggatatacgt gtattccccc acatgaaaca 89280 gtactccaca catagggagg attcaatcga gacttgatgc caaaacttag tggcccaaag 89340 tggcaaacat ttatgatttc tcatgattct gtgggggcag ctgtgcagct cttctagtaa 89400 ggagaggcac tctcttgatt ctcttaagtg tctgggcttc aaatcggatg gcaggcacaa 89460 ctgggcctca gcacatgctc tttaccctct ggtggactag cctagcctag tactcgggtg 89520 gtggacccat gtcccaggaa gccacaatgc tcatgccctt cccaactgct tgcatcacat 89580 ctggcaatat tcctgtgact aaagcaagtt gcatggccaa ctccagattg aaggagtaga 89640 gaagtcaggg gagcagccaa gtcacgttgc acaggacatg catgaggaat gagagaattt 89700 gttgcagcca ttttttgcaa atagtctacc atagaagctg agtgacatga ccttttatat 89760 atgtggaaga gtaacaatat atacacatgg gctgggcacg atggcttacg cctgtaatcc 89820 cagcactttg ggaggccgag acgggtggat cacgaggtca ggagatcgag accatcttgg 89880 ctaacatggt gaaaccccgt ctctactaaa aatacaaaaa aaattagccg ggcttggtgg 89940 tgggcacctg tagtcccagc tacttgggag gctaagcagg agaatggtgt gaaccccgga 90000 ggtggagctt gcagtgagcc gagatcatgc cactgcactc cagcctgggc aacagagcaa 90060 gactccatct caaaaaaata aaataaaaat aaaaataaaa tacacacaca tacacacaca 90120 cacacacaca cacacacgac catttgttgg gcaatctttc ttacaggctg aattgtaaat 90180 attccagaga taaatcgcac agacttggga gttatatcgt ctggcttgca atactacctc 90240 taagatgtgc aaactgtatg gcctttgacc aacctttctg tgcctcagct tcctcattta 90300 taaaacaaga ataataatac ctccctccta tggctgtgag ttgtaggata aaagaagtta 90360 aaatatgaag tgtttagtac agtgtatttg tctattcttg cattgccata aagaaatgcc 90420 tgggctgcgc gtggtggctc atgcctgtaa tcccagcact ttgggaggcc gagatgggtg 90480 gatcacttga ggtcagaaac tcaagaccag cctgaccaac atgatgaaac cccatctgtg 90540 ctaaaaatac aaaaattagc tgggcattgt ggcaggagcc tgtaatccca gctacttggg 90600 aggctgaggc aggacaatca cttgaacctg ggaggcagag attgcaatga accgagatca 90660 tgccaatgca ctccagctag ggtgacagag caaaactcta actcaaacaa aaaaaaagag 90720 actgagtaat ttataaagaa aagaggttta attggctcac tgttctgtag gctgtacaag 90780 aagcataata ctggcatctg ctcagcttct ggggaggctg caggaagctt agaatcatgg 90840 cagaaggcaa agagggagca ggcagctcct atggccagag cgggaggaag agagggggga 90900 ggtgccacaa actttcaaat aaccagatct cacaagaact cactcattat cgtgacagta 90960 ccaggaggat ggcactaaac cattcatgag aaatccaccc ccatgattca gtcacctccc 91020 accagacccc accttcaaca ttggaaatga catttcaaca taagtttttg gcagggccac 91080 atatccaaac cgtatcatac agtgacatgc ataaagcaat tactaaataa gtgctatctg 91140 ttttaattta attcccaact tcttgcatca gatctgccaa tattcctgta actaaagcca 91200 gttgcatggc gaacaccaga ttctaggagt agagaagtca ggggagcagc aaagtcacat 91260 tgcaaaggac atgcatgaag gatgacagaa tttattgcag ccattttttg caaatagtct 91320 gccatagaag ctatatgaat atctcatttc aagatgtatg agcatctcat tttgctctta 91380 aattcacatc agtaaacttt ggaatcccct acacaactcg cctatacctt ggggggccag 91440 ggtgctacct cagtcctgct ctctgcctta tctttttatt gcagcatttt cactctgctg 91500 tggcctctca gggtagggga gaccttccct ttccttttct ccactcctac caatccagag 91560 tttctatcat ctaaaccata cccaccctca aatctaagat tcctctcaag aatccaggca 91620 acatcttttt aaaaactttt ttatttttta tttatttttt agcaggtggg gacagagcct 91680 ttttatgtca cccaggctga aatgcaatga catgatctca gctcactgca aactctgcct 91740 cccgggttca agcaattcta ctgcctcagc cttctaagta gctgggatta taggcatgca 91800 ccaccacgcc cagctaattt ttgtattttt agtagagaca gtgtttcacc atgttggcca 91860 ggctggcctt gaactcctga cctcatgatc cgcccacctc tgcctcccaa agtgctggga 91920 ttacaggcat gagccaccgt aactggaccc taggcaacat cttaacctca tccttatccc 91980 ccaaatctct ccatgtcctg cccactgcat catctccctt cctcttccat gttgtgggaa 92040 ctctgtcctg agccatattc taagtcttca caccatgtct tgtggcaaaa ctccatcatt 92100 agacctccaa gctttgttct gccttaatgc agaaggaggc tttgggaatt tagaaaactc 92160 tcttccctct caattgtcct ataaatccag actttcaaat gaaatgctta ccatagactt 92220 gagaaacaaa tcagaaactc agagcaaaac cctgagtctt tattttaggc tgtatctttc 92280 tttgaagcaa tggctgccat caactccgtg tgtgaaggag acacaggaca attaagaaac 92340 aaaaatgagc ggtggtgttg caggtgctgt tggtgcctgc ctggagcctg tcacctcctt 92400 accatttcct ggcagcactt ccagctgccc agtagcaaca cttcccctaa ggactctctt 92460 tggcaggtga aagtgcctga gattgactcc tgagagcagc cacggccagt gacagccgga 92520 ggtggtgatg taaacctcag ctagctaggc tttcaggaag agtaactgag gcagggtcct 92580 gctctggttc tcagtgtctc caagagatga agctgccatt tctcatagtg gcgacttgct 92640 ataatgtgcc cttcattgac cgtcttcctt ttattgttca cttgcctcct ttcctgcctg 92700 tgtttcctga aaccaactac ctcacataaa ctacttttgc ttgaatccct gtcacagagt 92760 ctccttctgg gggattctga aggtagacac atttaatatg tcaaaagtat tgcacctgtt 92820 gtgtgtttta ggggagtgat gattagcaga aaatagaaag gaggctatta tagtggtcct 92880 gggcatggga gaacaagagc aggtgctgat aaaatcagga gaacttgaat agtggcagag 92940 ctggcagaaa cacggaggat gtgtcggagg gtctggtgtg cggttgctcc ccacagcgga 93000 gtctgagcaa gaaaagaggc tctggcctga tggcaagaag acctcacggc tgtttcttgc 93060 cattgctgtc actgtcatgt tcataggttc actgcccata gcaactgaaa gaatgtcaaa 93120 tgcttgcaca acccccttca atttgtagat gaaaactgga agtgtggaca ggttaagtgg 93180 aagctcaagg tcataaagcc agccagctgc agaaccttgc actgtaagtt tttgttcgtg 93240 acaaggccca gctccacttc aggtgcggtt cagatttttg tcttcattcg ttctataaaa 93300 cttcattttt tgctttttac ttctcgactc ttctaattgt cctttgtatg tctattaggt 93360 gtgggtcccc cattaggctg atctgtagca taatttctac aataggaaag ggagataaat 93420 aggacattta agatgcctgg actcatctaa aggttgttta aaagcaatta ctaccattag 93480 tttgaagcct acctctggct actctgatag taatgtgcac ccagcaatcc aattagtttg 93540 gaaatggatt agtctatttg ttaccaatgt gtgtggttta aaatcagtat aatatacatc 93600 taaaggtgtg tccattttat ctattgacac tttgtataaa tgtgttgctt catctttccg 93660 taggtaattt actcactccc ttctcccata ctaaatgttt cttcattaca aattgatttc 93720 ctaaactatg attcatgatg tttcagtttc attgtcttta ttaaatgact gtaattcttt 93780 ctttagtttt aaggatttcc attttgtgtc accacattgg actaaccatg gacaaccaga 93840 ttttccatag aatgaggtca ttttctggga actaacagac caaggaatac cccctgatat 93900 actacattgg aggaatcctt gcagatactc tctccaaatg tgttaaataa ataaaatagt 93960 atgttcatca agtacctctg gggtaccaga agcacagata agctggtgtc caacatggag 94020 caagtctggc attgaggtgt tagaagaaaa aggctgggct ccctgaactc tgttacatgg 94080 tggaggctga ggggcctgtt gtgtagattc aggtgcaggc cacgtgacag ggtgttagcc 94140 atgtaagtcc atattttctc ccattgcttc acatctattt catctattac ttcattcatt 94200 caacaaatgc ttagtgtcta ttatttaaac gtttctgggg atatactagt gaacaaaaca 94260 cttgcctttc ctccttgctt ccctcttctc cccttctctc ctcctttcct tccttttgta 94320 attctttact ccccgctttt taaaattgag cttattttca gggcttcctt tgaacatctg 94380 cattcttatc cagttttgga acactatttg tgttgttgtt gttctgttgg acagggtctt 94440 tctccgatgc ccaggctgga gtacagtgat gtaatcatgg ctccctgtga cctcaaactc 94500 ctgggctcag gtgctcctct cgcctcagcc ttctcagtat ctaggattac aaacacaagt 94560 ccctgcaccc aatctataaa agtatttttt taaataactg catattttat cacatattgc 94620 ctcaaatctt gttggtcctc ttgccaaatt gtcagatatt agtggagaca caggtcagtt 94680 tcccaaggaa aagcattaaa cgtggtccct gcctcttgct gcagcatttg gctgcaggaa 94740 tgtgtgtgga ttccaagcca gagggagggc cccacctcat taagccgacc taggggaggg 94800 ccccagctgt gctcagtcag gaggaagagg tgagctggct ttggagaaaa gaagaggtta 94860 cagcagaaag gaagcaccca ttcttgacag agtcttaggg agccttctct cctttctgga 94920 tacaaagctt cacactataa taaaaccatg tggcttatgt agttaattgg tagattatta 94980 ttaccatgta caaagtgctg tcaggagtgc aaaagaaaag atgacctgca ctttattctt 95040 gttttgactc ttcttggagt tttgtctatt gggatgtttg ccatccagtt gggctataga 95100 gctaacaatg aatagtgtga atttgctgca cagtgagctg gtaatgcagc agataagcag 95160 aacagaggca tcagatcagt ggccgaggag atggggatgg ggtcatttat attatgaata 95220 ttggattaca aggaggtgat gcactctgct tgcttcaatg attttttaaa tgtaactttg 95280 tctttttttg tcttttaaaa atgtaactta atttttttta cacaaaatat aaacatgaat 95340 agaaccccac ttaagaaata gaaaagtgtc cttgaaaagg cccctgtgtg ctcctctcca 95400 atcacgtccc caccccaccc tacagtagga acccctctcc tgaactcctt gttaactaat 95460 cctcaatgtt ctttgtagtt gtaccacatg tttgtagcct taagtaatat tttgctaaga 95520 tgtgcatgct cttgaacttt atgtaattag aatcacagag gaagagttct tctgggacta 95580 gctttgttct ccacattatt gctttgagat ttatccatgg tgatgtgtgt agtttgttca 95640 tttattcaac aaataaattt tggaggcaaa tactgagtgc cacacatggt ttctggctgc 95700 tggggataca gtgtgaacaa aacaggcgga agccttcatc ttaaggtagc tttattctag 95760 tgggtgtggg agagcaatgc atcagataaa tgaatatgta gactagtaga ttgtaattag 95820 tgcaaagaaa ctgaagcagt gaagaagagt aattttaagg gagacgtgga gtttcagata 95880 ggctagagtc ggtctcgctg agaaggggca cttgagtgaa acctaaacga agtgatagag 95940 tcctggggat gtcagcgggg gtggaagagg gcttttcagg cagagcaaac agcaaacacc 96000 aaggcctgca gcagcctgtg tgacaagagc agggttagca agggagggac aggaagggga 96060 gatagggaca gagaggatgt tggaggtttt tgaacagggt ggcattatat gacttatgct 96120 ttaacaagat ttatctggct attgtgttga gcatagagct gaaggggcat ggggactgga 96180 gcgagggctc caggtgggag tcattttagt cattctaacg agagatggtg tggacatggg 96240 gaaaggagca gcgtgctggg tgcatcacaa aggctgagtg taggattttc tgataggttg 96300 gatttgaggt gacagaaaaa gtgagaaatc aaggactgta gcctgagcag ttagaatggc 96360 agagggactg ctcatcgagt gagggaaaca gggcagggaa ggaagatcag gggctcagta 96420 aaaagaatgt tcggtttctg atgcaaattc aacatcctgg tgcagatgtg agcaggcagt 96480 tgggtgtaga agtttggagt ttagataaga ggtctggatc agacatggaa attttgttgc 96540 tgccagcctg gagatgatac taaaaacctt cagaacgggt gagatcaaag ggagaaaggg 96600 agtgagtaca aagagactgg gaaagaaaga aagtccagag actgtgttct gggatccttc 96660 aaaacgtaga aatcaggaag taggaaccag caacagagac ttagaaaaag cagcaagaaa 96720 attcctatca gagggaaacc atgcatgatc aatagtgtca attatcactg ctacagcaaa 96780 acacaggcca ctggtgactg caagagcatg ttcagtggag tggaggggac aaaagccagc 96840 ttaaaatgag agactaggag gctgagggag aaagtggagc caatgaggtc aggcatggtg 96900 gctcatgcct gtaatcccag cacattggga ggctgagatg ggtggatcac ctcaggttgg 96960 gagtttgaga ccagcctggc caacatggtg aaactccatc tctgctaaat atataaaaat 97020 tagctgggtg tggtggcggg cacctgtaat cgcagctact caggaggctg aggcaggaga 97080 atcacttgaa cccaggaggt agaggatcca gtgagctgag atcacaccac tgcactccag 97140 cctgggtaac atgtctcaaa aaaggaaaaa aaaaaagaag aagaaagtgg agccaatgaa 97200 ggattagagg ggagaggcta cgtgggagaa ataacaaggt ttcagacagt tacaggccgc 97260 cctttataca ttcctctgta ggtgcacatt taagtcagtt ccatctctca gcttctgtga 97320 acagcgctgg agtaaacatg gagtacagac atcccttcaa cacactgatt tcatttcctt 97380 tagatctata tccagtaatg ggactgctgg ctcatatgct atttctattt ttaaattttt 97440 gaggatcttt catgcctctt tccataatgg ctatacttat ttacattctc accaacagcg 97500 tggaagagct ctcttttctc cacatcctca ccagcatttg ttaaattttt tgtgtgtttt 97560 tgatgataac cattctaagg tgaagggata tctcattgtg gttttgattt gcatttccct 97620 gatgattagt gatgttgagc attttttcat atagctgttg gccatttgta tgtcttcctt 97680 tgaaaaatat ctattcagat cttttgtcca tttttaaatt taattatttg cttttttgat 97740 attgagttgt ttgagttcct tatatattat ggatattaat cccttgtcag atgcatagtg 97800 cacaaatagt tttttttccc cattctgtaa gttgtctctt caatctgtta tttcctttgc 97860 tgtgcaaaag atttttaatt tgatataatt ccatttgtct atttttgctc ttgttgtctg 97920 tgcttttgag gttgtcttta aagaatcctt gctccattcc atgaagcatt tcctctatgt 97980 tttcttctag tagtttcata gttatggtcc taacacttaa gcctctgatc ttatttgagt 98040 tgatttttga atatggagat agtgatctag ttacattctt ctgcatgtgg atatccagtt 98100 tccgaggacc gtttattgag gatactgtcc tttccccaat gagtacttct ggtgcctttg 98160 ttaaaaatca tttggatata catacatata tttatttcta ggttctgtat tttgtcacat 98220 tcatcaatgt atctgttttt acgccagtgt catcctgttt tggttactat agctatgcag 98280 tatattttca tcaggtagag tgatgcctga agctttgttc tttttgctga agattccttt 98340 agctctccag gatcttttgc atttccatat gaattttagg attgttattt ctattgcagt 98400 gaagaatgtc attgagattt ttattataga gattgcatta aatctgtaga tcactttgga 98460 taatatgtat atttttaaac attatttcag tccatgaaca tggaatatct ttctaatttt 98520 ttgtgtcctc ttcgatttct ttcattggcg ttttatagtt ttcattgtag ggatttttca 98580 cctccttggt taagtttatt tataggcatt ttatttatac cttgtaacta ttgtacatgg 98640 aattactttt tcaatttcaa tttcaaatag tttgctattg gcatatagca aacactactg 98700 atttttatat gttaatttta tatcctacac ctttaccaaa ttcatttatt agttctaata 98760 tttttttttt gatggagtct ttaggctttt ctctaaccat ctatctaatt atgatgatat 98820 tgtctgcaaa cagggaaaat ttgactccct cttttcttaa tttggatgcc ttttctttct 98880 ttcccttgcc taattactct ggacagaatc ttcagtgcta tgttgaacaa aagtggtgaa 98940 tgtgggcatt tttgtcttgt tctacatctt agaaatgaag ttttcaactg tttcctgctc 99000 agtatgatgt tctctgtgga tttgtcatat atggccttta ttaaattaag gtgtgttgtt 99060 tttataacca atttctggag gatttttatg aaggaattga attttatcaa atttttttca 99120 gcatctattg aaattatcat atggatttgg ccttgattct gttaatgtgg taatattatg 99180 tttattgatt tgtgtatgtt gaatcattct tgcatctctg tgatgaatcc cacttgatca 99240 tggtgaatta tctttttaat atattattga attcagtttg gtactatttt cttgaggatt 99300 ttttgcatct gtattcatca ggaatattgg cctatagctt ccttttttgt tgttgtattc 99360 ttttctgatt tttggatcag ggtaatgctg gcctcataga atgagtttgg aagtgttccc 99420 tccttgtcaa ttttttggaa gaattggtag aattcttgtg agaaagatta gttgtaaatc 99480 ttctttaaat gtttggtaga atttatcagt gataccatta agtcttggga gttttttgaa 99540 tgggagattc tttagtactg cctcaatatg gttattcatt attggtctat taagattttc 99600 tatttcttca tgatttaatc ttgctaggtt gtgtctgtcc aaaatttact catttcttct 99660 agattttcca atttcttggc atatagaaat ttacaatagg ctcttatggt cctttaaatt 99720 tttgtagtat cagttttaat gtttcctttt tcatccctga ttttatttat ttgagtcctt 99780 tctctttttc cttagtctag cttaaggttt gttgtttttt ttttatttaa acaaaaatac 99840 ctccttgttt tcttgatctt ttgtattgtt tttaaaacct ctattttgtt tatttctgct 99900 ctgatttttg ttatttttcc ccttctaatt tggggttcag tttgtccttc ttttctaatt 99960 tcttgagttg tgacattgga ttttttattt gagatctctc tacattttgg atgtaggcat 100020 ttatcacagt aaaattccct cttagaactg cttttactat atcccatagg ttttggtatg 100080 ttgtgtgcat attttcattt gatcgagaaa tttttaaatt ttatttttga tttcttcact 100140 aactcctctg ttgctcagga gcgtgttgct taatttccat gaagttttac agttttgaac 100200 atttcttctg ttattgattt ttagttttat tccatggtgg tcagaaaaga cacatatgat 100260 tttgattttt aaaaaatttc taagacttgt tttgtgactt tcataatcta tcctggagaa 100320 aatatcatgt cttgttgaga aaaatgtgta ttctgaatct attgggtgga aagttctgta 100380 aatgtctgtt ggattcattt gatctagaag gctgtttaaa tccaacgtct ctttgttggt 100440 tttctgtctg gataaccttt ccattgctga aagtaggggt attaaagttc cctactctta 100500 ttgtattata gtcaatctac agacctttca gatctattaa tgttttcctt acatatttga 100560 gggtctcaaa tattgagagt cccagttttg ggtgcataca tatttacaat tgtaatgttc 100620 tctttctgta ttgatccctt tgtcattata tcatggtctt tttgtttatt ttttaccatt 100680 cttgacctaa agtctatttt atctgatata aatattgtta ttcctgcttt ttttttttgc 100740 ttcaatttgt ttggaatatc ttttttccat ctctttagtc tgtgcatgtt tttataggtg 100800 aaagatctct tgtagacagc atataattgg gcatttttaa aaatccattc agtcactcta 100860 tgtctcttaa ttggagattt taattcattt gcatttaagg ttattattgt taggtggggc 100920 tttactacta ccattttgtt acttgttttc tggttgtttt atagatcctt tctaccttgt 100980 ttcatctctt attgttttcc ttgagagatt ttttttttct agtagtatgt tttgatttca 101040 tgctcattat ttttagtgta tctattataa gtttttgctt tgtaaatacc atgatgctta 101100 aaatcatgtt atagttaaaa caagttatct taaactgatt aacaacttaa ctttgactgc 101160 aaattaaagc aagaaaaaca aactacattt aacaccatcc cacacacgtt catttttatt 101220 tttgatgttt caatttacat ctttttatat taactcttaa ctaattgttg taattactat 101280 ctttaataat tgtttcttta gtcttcatac ttaagatcca agtggtttac gttccacaat 101340 tacaatatta tagtattcta aatttgtctg tattcttact tttaccagtg aattttatac 101400 cgttagatct tttcttgtta caaattagca cccttttctt tcagatgaag aactcttgtc 101460 agcatttctt gtaagacaga tctgatgttg atgaatttcc tcagcttttc cttgtctggg 101520 aaagtcttta tctctccatt gtgtttgaag gatacatttt ccatgtgaac tattcttggc 101580 tacaaggttc tttcccttca gcactttgaa tatatcatcc caatctcttc tggcctgcag 101640 tgtatctgtt gagaaatctg ctgaaacttg cactggggct caggtgaatg tgatatgttt 101700 tctttctctt gctgctttga gtatttcttc tttatctttg ctttttgata atttgatgct 101760 gtgccttggt taatttctct ttgggttgaa tttgattggt gatctctgag ctttttatac 101820 ttggatactg tcctttttct ccagatttag gaatatctta gcgattattt ccttaaacat 101880 gctttctaga actttttctc ttttatctcc tggggaacta ctattatata gaggttagtt 101940 tgcctgatag tatctcataa ttctcatagg ccttcttcaa tcttttttta aagatttttc 102000 tcctctgatt gggtaatttt atatgttctg tctttgaggt tgtgggttct ttaagtctgc 102060 tattgaagat ttcgaataag cttttcataa atttcaataa gttcagttat tgtattcttt 102120 attcttagga tttctatttg gatttttaaa aagtgtttct atttacttgc taaatttctc 102180 aaattctttc aaaatttcac tgcattttcc atccacattt tcttgtgact ccctgaaatt 102240 aaagaggatt attctgaatt ctttctcaga catttgatag atatttaatt cttctgggtc 102300 cattattgga gttttgtttg tttcttttgg tggcatcata tttccctgag attgtttttg 102360 ttgttgtttt gtttttttta aacaattttt gcgtgtttta tgatgatgcc tgcatatttg 102420 aagagaaagc cactcttcca gcttctgctg gtgttattag tgttggacct ctactacttg 102480 atattgggac ttaatcactg ccctgccatt gtttcccagt ctagggaaca cttatagtga 102540 gcactggaac ttaaacactg gactagaact aaattgctac tctactattg tttcctggtc 102600 tgggaaagac ttaaatacgt actggaactt aatttccaaa ggaacttaat ttccaaactc 102660 agttgtttcc aggtcagggg aagactccac atgagcacct gagctttgtg ggaagtctgg 102720 ccagagattc agaccttcct gccgatcatg cttcctgcag cactatagtg ctggccggtc 102780 tcctcagtat gacatctgca tccctgctga ttggagctcc aagattccag caccaagtga 102840 tcagcacccc cactttttgt ccccagttca ccccaggtag ttcagccctc ctagctctcc 102900 caggggttcc tgtgcagtga gacctgagtg ggcttcccat gaagattccc atactggtag 102960 ggggatcaaa catccacctc caattccatc ttcccacctt agaaaccatg agtctgtgtc 103020 aattctctgt gagtggcatt atacaagcct ggagaagaga gtggcacagt ctgaaatgac 103080 catttttctt agttattatg gcctagtggg tttctccact tctccccaag ttctggtgaa 103140 ttcatggtgg tattcttgtc ttttaatagt ttccagttgt atgtttgtgg aggaaataat 103200 gtcagggtgt cttctattct gcaatcttgc tcatgtttct ccttcataat tactgttact 103260 ttttatagaa ttgtatttag atctattggt cagcagattt gattataaga aattttgacc 103320 tatttacatc atgagaacaa agaaaaattt tgagaaatga tagggagaat tcctcagatc 103380 aaggacttgt gaaagatcct gagaactgtt gaccagacag aaacatggta tcagaataac 103440 tctcttgtat cacaaaattt ttttttaaat gtacttcttt atctcaaatt ttaatttttt 103500 aaaatataca tttgattgtt tttttcttct agtataagca gatcctcact gcatgttttg 103560 gggtgtgaaa ttcgacatct ctagcaggtt aacctcttgt attatgtcag agtggggaat 103620 aagctcagaa aaatataatt tatggagaac attttctcat tttctgggac cttgtaaaga 103680 ccttatttgt tccaggtgac aggccccaag tggaataaaa ggccattatt gtgagaaatg 103740 acaactcaga tatagcaaag ttgttgccag gagttgatga tgcagaaaca atttattttg 103800 ggcaagatgg tattgaatgg ggagtctatt agtggtattt taccatgtga atttctatat 103860 gaaccatgtc tgtgggagca ctgctgcatt catttgtggg atgtactgct ttttgctagt 103920 tgccgtcaat aaaatctgtt ctgtagctct tcaaagtggt tgattcagcc actctgtatt 103980 caggccataa agatcatgaa atgaaagtct tctgagctcc aattagagtg gaatgttata 104040 tctcaatgca gaagtcttct tcagtaaagt aagtgtaagt ataaatttgt ttagtgaaaa 104100 gtaccttttg gaaattgtac ttttgagaca gaggcattca aactctgact accgcttgcc 104160 aggtgggtaa tttaggggat actgcttaac ttttttgata attgtatttc ctcatcttta 104220 aaataaaaat aatgatgaaa atgttaatta aaaggatgat gatgatattg acaataatgg 104280 caatgatgat catgacagtg aagatggcaa taacagtaac aatgaatctg gtgatgatga 104340 tgacaatctc aaacaactgt tgtaaggata ggacgtaatc cattcaaagt aaccagcaca 104400 gaccctggcc cactaaaggg agatcattaa atttcagctg cccttaactg ctttctcaaa 104460 cctctactct gttttctgga ttttctttat ttgtgtatat gtatcagttt tatattgctg 104520 ctgtcacaaa ttatcacaaa cgtagtggct taaaacaaca tacatttatt ctcttgcaac 104580 tctgaaggac agaagtacaa aatcactttc actggatgaa aatcagtgtg tcagtaggac 104640 catgtccttt cagagtctgt agaagagaac ccattccctt ggcttctcca gccctacagt 104700 ggtgctcctc atattccttg gctcctgacc cctttctcca tctttaaaca aattcattaa 104760 agttgcagga tacaaaaatc aacatacaaa aattagttgc atgtctatga gctacaccaa 104820 taatgagcta ccagaaaaag aaattgggaa atgagctgca tagtgaagta atcagaaatc 104880 aattcactgt ccttagttct gctgggacct cctgttcagg atttggcagt accagtgaca 104940 aaggctaaag ctgcttggaa ttatatattc tccatcttaa aatgccaagg ttaccttgga 105000 cttcaacctc agatgtcgca tgtgactgtc taggttgtac ataaagatac gaagggtgcc 105060 cattgaagtt ggccagtgca caacttgtgt ggctgtacgt ggtgggcttt ttctgatgcc 105120 caccagacta aaaactctag aaatgtgtga tctctatcta tcttgtattc tcagcaccta 105180 ctgcagttct tggcatacag tagaaattct catttaagga aatgaaggaa tgaacatata 105240 ggaatagtca atacaagaac actaagtaac acctcatctg gagttactca ggtcagtata 105300 ctgagctgct cattcgaatc acctggtgga aattttaaaa aataaaaatc tcagcccaga 105360 tcctattgac agacattctg atttatttca tctggatggg gctgcagtat tactgctttt 105420 ctaagaagta tccaggtgaa tctaccgtgc agccaggtag ctagaacctg ctagtctgga 105480 agagtggttc tcagacttca tgcattaaat ttacccagtg gacttgttaa acacacaggt 105540 gacttttctt actctgtcac tctgagtttg ggggctgaga tattgcattt ctagtaatca 105600 ctcaggtaag gctgatgttg ttggtatggg gaaccatggt ttgagaactg ctattcagga 105660 agacagcaga gaagataagt tcctttagtg tgcataggtg gaaaacagtt ggtagagtga 105720 ttctggaaga gtgcatgcat gtgcattcac atgttttatt aacatgtgaa tatgaaagat 105780 attaagcacc catttgtcca ttttaaatat ataattgtat cccttctgtc caacagcatt 105840 tcactgtaga catttttaag tgtcagtttt ttagctgaaa aactagaaaa ccaaggaagt 105900 aaatcattgc ccaagctaga cttgatcttt tcagcatgtc agagtctcat gctttagaaa 105960 accagagacc actctcacta ttttgtgttc atcctctttc tccatttcca gtcacttttt 106020 ctgcactgac ttcaggttaa tcttccataa gagggccttg gtgttctcat cttattccta 106080 tgcccccact aaattctgag taagtgtaac agcctttgtc cttctgcatg ccacacagta 106140 gttacctagc taagatattg tcaatcagtt tgagagacta taagctgcct aacctagagt 106200 tggaggataa taccaatctg agatcttctg agcttagcat cattatcaac ttctgttact 106260 tccactaaaa cctttgtaaa tcacagcaga tatatttcag aactgtgcca cttatctcag 106320 tgcctccagg catttcaaag tagtcacttc acacttgcca tcctccctgt ccttctgagt 106380 cctcctctca gccccagtgt gtctaccacc tcaaagccta tggttgttag cctgccttac 106440 ttgggtcaaa gaccttgact ccttccagat ggatcctaaa cttcccttcc attcacttta 106500 tccaaaatga aattgtacat tcttgaaata cacagcagca ctcaacaaat gctgaaaatt 106560 atatgattaa agtaatttgc actcaaatgt aaataaggct tgatgctcca tggaagtttt 106620 gaattttaaa gaagagcttt ttattcccaa tggctctaat gtgtgggaaa catattgggg 106680 gaggaggcac atggggtcag caaatgctgt ggacaattct ctgccctctt tacctgggct 106740 gccgttagtt tgtctggcag ggactgaata tatggcttta atattctggc caaactatct 106800 cctcatctcc ccttagcttt gcaaagtggc tgcagtaaaa cctgccatgc ttggattggc 106860 acggctcaaa gctaactgta tttgaaactt cacatttcaa atctcgaaga agacttctgt 106920 attaaattta gagtttttta tcctcaaagg agttgtacat tttatttgtg tcaaaattta 106980 cagagcactg tcttaggcgc tttctagcag ttgctttaaa gggttgtcag ctccaggcat 107040 ttcctctgcc cacatacagg tgttgtcaca tgttcccagg tgaggagtta gcaagggttt 107100 gctgtagctc ttggtttaaa tgttggcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaat 107160 tacacctgca tcatctagag gtggcctttc ccaatggaca tttccacttg tgatgatgga 107220 ctgaatattg aaaatcattt ctggaaactg taaagtgaaa gaagccactg acactgaact 107280 gcctgccaga atcaggagat aatttctttt ctgggggaaa aaaaaaaaaa aactaattct 107340 ctaagtttta actgatttcg ggaagttaaa actacagttt atccccaggg ttatgggcca 107400 aactgtactt ttaaaaaaat tatatgttga attcctaacc cccagtacct cgggatgtga 107460 ctggatttgg agatagagtc tttaacgagg tgatgaagtt aaaataatgt cattaagttt 107520 ggctctaatg cagtctgact ggcatcctta taagaagagg agattaggac aaagactcac 107580 acagagggat agccctgtga agacacagga aagagagagg ccccaggaag agccaatcct 107640 gcagacaact tggtcctgga cttctagcat ctaggactgt gagaactaaa tttcagttgt 107700 ttaagccact catctgtagt gctttgttat ggcagcccca gcaacaagaa agttgttgtc 107760 aaagaataca tccttttgct ggaccagcct ctctggggct gccccttccc tgagcaggtg 107820 gatttctctg tccgactcct caagggcatg gcccccacct ccccccagca ttgctgcaga 107880 cagtgctcct gccattgtcc tcttgtcgcc tgtctaggtt tggttgtcct tgttctttcc 107940 tctttgccta tggctgaaat taagaatggt gacaagataa gactataatc ctctccttta 108000 gtctcagtac aaataatacc acattaaaat ctggagaaaa ggaacatgat gatccatggg 108060 aaggacagcc agctctgtaa aagcatcact ggacgctagc agaaatggtg cactccccac 108120 cagaactcat gctccccctt cttcctgcag ggttggagct gggaagcagc tgcccagaca 108180 caggctgtgg tttccatccc tctccttgtt ggggattgtc cgtgtgactc gcccctgctg 108240 agggatggcg agttgaagtg atgcaccttc caagccttgg tagtgaagca ggaagtgtgt 108300 ttctctgcat tctctgctat ctggttctag gactttgctt ctccaagtgt ggtcccctga 108360 ctggcagcat caacgtcact cgatgatttg tgagatgcgc aaaacctggg gcccattcct 108420 gacctactga atcagattct ctggggtggg gccccgcaat ctgtctttga acaatcactc 108480 taggtgattc taattgacct ccactttgaa aaacactggg atagaggaca tgagaggtct 108540 ccaaaaggca agaaccaagg ttcctgaatt gttgtgtaga ggaagggcac ccaccaatca 108600 tgaacactac tggggtgacc ttcatgtgac tcctaagcaa gatgtaaatg cctgttagct 108660 tggaccactg aaattctggg gtttatttgt tacaacagtt aggattgtcc ttaatgaagg 108720 gcagaagaag atgcgattac aattaagtgg ttacagaacc agctctgggt ccctgatgca 108780 actctttccc actgtttgct ttaggaaaag agcaagagtt agaatttcat gcattggcat 108840 ggtctacctg caacctgttg tgcattttaa tttaatttag tttcttggta aaatttttaa 108900 aaccttattt ggtaacctct caaaagcaag aaactaattg ttcttctgat gtaaaatatc 108960 aagcaaatac aatcaactat tgctacttac ggggaggggg tacataacag agcagaccct 109020 tctctttgcc aagactgtcg tgaaatgcat ttcacatgaa tgaaacatat gcctcccact 109080 agtaggagcc acagcatccc ttgaaggcta tcactcccct gaaatgagag ctacctctca 109140 gactaaagtg tggtcagaaa gggagacttg aatgggagga tcattttatt gactgtgcct 109200 tcagaaaaag aaggtggttt ctgcatgaca ggaggtaagg ctgcacctca ccttgatatg 109260 ggctggaaga ctgggagccc agaacccact caagagcccc ttctgaggtc agctggatgc 109320 tggatgtggc caggctctgg aaagccagca gagaatgaga tgctctttct gcctgcggag 109380 attgtgttcc tctccctgtg gcttagtgtc atcagcccta taatcacctg atagtcatga 109440 cacatgaacc cagacaggtt gctgagtgtt tttgagatgg agttttgctc ttttgcctag 109500 gctggagtta agtggtgcaa tctcggctca ctgcaacctt tgcccccttg gttcaagtga 109560 ttctcctgcc tcagcctccc gagtagctgg gattataggc acctgccact atgcccagct 109620 aatttttgta ttttttttag tagagatggg gattcaccat gttggccagg ctggtatcaa 109680 actcctgacc tcaggtgatc cacctgcttc ggcctcctaa aatgctggca ttacaggcgt 109740 gagccactgt ccggccggtt gctgagtttt taaaagcaaa cctctccagt aactgggtaa 109800 aatgttgatg tatttcctta taaagctgtg tgtctctatt ttttatatat atacacttgt 109860 gatcctataa tatgtatcat ttctgcctta cagtgaaatt aaagcctgcc ttttatttta 109920 taaccaagag tcagaattca agaaattcac tagtaaagca atccattagt aaaaataaga 109980 aattagaata aaggaaaata ttgtctattg tcctaactcc cataattcta gaatcttcct 110040 tacagtattt gttccgtagc atcaacttgc tttctgattg aaatcactgt gtgactgtaa 110100 ttttgctttc tgcttaacat tttatcttaa gtattttcta tagtgtttca cggtcttttt 110160 aaatgtaatt tttgatccat aatattccat aaaactaaag ttccacaata aactatcttc 110220 ttcttgtgga gtagttatat aattttcaat tctataaggg tttttaagta aaattaaaaa 110280 gaataacttg gtgcaaaaaa aaccctatgc tatttaagat tgtaacttca gtatatgtta 110340 tagaagaaag aagcttgggc ttgacaatct gtgacatcat agaaagatat ttggtctttg 110400 tccctggttc ttgacacagg agctcctaaa acccttgaga tgtcctgaat gacaagtgtg 110460 aaggaagcct cttttgttct aatgaggtgg ttggaggccc tagatacctt caggatgggg 110520 ggctgcacac caaaaagacc aagtcacagt gacagggttg gtcacaattg gggaagcctc 110580 agaagaaatc aaccctgtgg atactgtgat cttgaacttc taacctccag aaccatgaca 110640 agatacattt ctgttgtttg agctgcccag cctgtgatat ttcgttacag ccctagcaaa 110700 ctaatatacc cacggccccc atgagcttac cccctgactt ttggagagag aagaggagct 110760 ggaagttgag ttcagttacc aatggccaat gatgtcatca atcaagccta tgtaatagaa 110820 ccaccagaaa gccccctaaa tgatgggctt cagaggagag ctcctgggtg ggtaaatatc 110880 cttgagtgaa gagagggtga tgcgtccagg gagggagtag gggctctgtg tccctttccc 110940 cataccttgc cctatgcatc tctcctcaca tttggctatt tctgagttac atcctttatt 111000 tgaaactgat aatactaagt aaagtgattt cctgagtttt gtgagcagtt ctagcaaatt 111060 atgaaaactg aaaggggaga ttcataggtt ccccttgact ttgtattcaa gttggactga 111120 agtgtgggta gcctggggat gagctacttg cacctggcat cagaagtgag ggcaatctcg 111180 gggaatggag cccttaagct gggggtgggg aagtctgcac tacctctggg tagtgagtgt 111240 cagaactgat ctgaaatgta ggatatgcat ttgctcttcc agagagaatt ggttggtgtg 111300 agaaaaaagt ctgcccattt ggtatcagaa atgctgtaaa taaaaaatag tgcagaatgc 111360 aacagatttg ggtttgaatc atgactctgt cactttctag ccatgtggcc tttgtgatct 111420 ttcatacatt agttaatatc tgtcctcctt cttaaaatag gactaatctc taccctataa 111480 ggtgctggtg gttgttcttt gagggctaaa ggatgcaatg acatttcaaa tctcttagca 111540 cagtgtgtct ggaatgtagg tgggtactgc acaaatggta aatatttgta ttacaaaata 111600 ggcccccaaa agtggaaata ctgggcaaga gtttgcagcc tttttttggg atcttgacac 111660 ctatagccaa cttgctttct aaaacatgca cacactcatt tcagatgaaa gcaagtgtgt 111720 tttaaacact gtggcagttt gtaacagttc cttaattgct gtaaattgta tacgttcctt 111780 aactagttgt atttcctcct tgctacttgc ctgctcatgt atcttttgaa tggaatttaa 111840 ttcagtaaac acaaatagtc atctagcttg tatcagtgcc gtactaggtg ttagaaatgc 111900 aagcataata ggatgcagta cttacccatt tggaacttta aatcaactgg aggagaaaaa 111960 cacgtggatc agtaccctca gtgtgataca tgcaaataac atatatgtac aggcaaagag 112020 aacagagagt aatgaattcc tttgctaatt tatctctcaa tgctttagca attttttaaa 112080 aattcatttg tgaatagttg accagtttaa atattgaacc aaccagcatt tctgttttgt 112140 gacaataaca agtcaaaatc caagattctc ttcttacttt gtctactctc ttctcttcca 112200 aaagcacatt cacgtttgtc tacataaata catgagaaca ttcagaaccc aagaaggtgg 112260 actgacaaag ctgagggacg gtagagactg cacgtattaa acaagcagga aaacaaccct 112320 cagagtctac attttcatac aacattagaa ggaaaaaagg gtattaactg aaaagaaggg 112380 tgtggaaatc aagtgtgaac gagccatatt gaaactctgg ctggaatggt gggatggagg 112440 tcccagttga atttttccta agaggctgct tggtaaacat tatctgtaga cctctccgac 112500 aattggattt acattcgaag aagcagattg aggctcaccc tgatagaaga aagtgcagtg 112560 atttacacag gttggatgga agacctttct gtcctttgtg tatgcatggc ttgactctaa 112620 gctctggccc ctttgtctct taaagaggcc tttctcaagg tggctcttga atatttttaa 112680 aagtattttt caaggctccc tgcatccaag catggcaccc atgtgctgtg ggtccttctc 112740 tccctctggc ccatgagtga cttatctgag agatgggttt gggaagagga agcagcgtgc 112800 cccttttctt atcttcctcc tgctctcctc ttgtagcccc gtagcttgat ctctgtagat 112860 gctgttaaag tggaaagctt caggtgaaaa tttccttgga ttggagactc tcagtgtcat 112920 cttttgacaa catttagcgt ttcttggggt gactccgatt tctagatgac cccacatcgc 112980 atctaatgca catctaagtt aatcctcaca gggcttactc tgcttatcat ttattaagga 113040 ctgacatttg tataattaag ttagggccca tcatctgttt aagattcaac agtaagtgat 113100 gtcggggttt acggatgcca agacacccca gctccctgcc tatatttgga atcaattaac 113160 agaaagatat agagaggggt caggtggaga tcaaatatca tctgtttatg acaaagtctg 113220 agcttgacaa tgtggtgctg acgggtggca gcaatggcct tgctaatcct aaaccccaga 113280 accaaaccaa gccaggcccc tggagccctt cccccaacca caagcagggt cttgctgcaa 113340 cttaacatgg ggagagtgga gcagagcaga gcagtgggca tggcccctga ggtcaaggag 113400 gctagagggg agaagaaaag gaggcgtgtc actttctctt cccaaactca cctctctgat 113460 aagtcactca tgggccagag ggagagcagg acccacagtc tatgggtgcc atgctcagag 113520 gcaaggtttc tcagcagcgg cctattgaca ttttgggttg gatggttctt caatgggagg 113580 gactgtccca cacacagtgg gatgtttggc cacatccctg gcctctactc attagatggc 113640 atagcactcc ccaaaccctc cctcatgaca atcaacagta tctccaaaca ttgctaattt 113700 tccctaggga gggcaaaatt acccccagtg gagtaattcc gcttctccaa tgtgaggtct 113760 caccaaaaag tagactggga gtagggaatt gaaaccgcaa aagaaactgc aggcagcaac 113820 ctcctcagtc ccatcagtca gtatccagca ggctcctctg ttctttccaa gctcctggtt 113880 catacctccc ctggcacttg tctccagcct gcctccctgt aagtgcctct ccagtgggtt 113940 atttacgagt gcagcaacta cctggccttt tgcccctcca gcacctgcat gcatgtctgc 114000 accctcccag tgcctggcac agtttgccat acctggggcc tcttttgtat aggtcaggaa 114060 ggtaatgatt ttagagaaag tttctcagat acaggaagaa aaaaatagat gagagtattt 114120 tcccatatta atctttaact gtcgctgtaa ttgcctcaaa tcactttatg catcgtctga 114180 cctgccaatc acatggatct tacccagcat agaaaagcag agactctgaa atagtagaaa 114240 aaatagcaag tgatcatcat atccgtggtg ctggctccaa gcccaggact cgcacaaagt 114300 accattaaat ggtgataata gtcacatata ttgctttctt cacattttaa gtcctctcaa 114360 aaagtgtttc atattcatca tttgtatgca tttgtcttgg attcaggcta gacttttcta 114420 gttttatgat acaagtagct aattaggact agtatagggg caaaagtaac ttattttgca 114480 aagcatgctc acttgaaatt gcctcaataa ttgtatgagc tattttagga atcagagcta 114540 atgtgtgatt aattagagga ccttgtccac atcagtcagg caaggagcct ccaaggagat 114600 gaagttattg aatcagtgta tctcctctaa ggcagagaaa catgcattct tcttgtgatt 114660 tcatgactct taattggaat gagtaagaga ctagatattg ctgagtcaac cttcaaggtt 114720 cttggcatct ccaatacacc attctccttg aaaacatttc agtatgttca atgttgggca 114780 gttctaattg ttagaatgtt ctgccttaca tggtggtggc atctgcctct ctttaacttc 114840 attcttaaag gaagggaggg tcctagggtg atataataga tttcatcctc ctgcccacag 114900 cagtcattgc agaatcttca gaattctatc acatttgtcc catattatgg tccctggttc 114960 ctctaccatc cttgtttccc tctgttaggg gttgaatggt atcccccaaa aactatgttg 115020 aagccttaac cactgacctc agaaggtgat tgtatgtgga gatggggctt ttaaagaggt 115080 aattaagcag gcctggtgtg gtggctcctg cctgtaatcc cagcacttta ggaggccaaa 115140 gcaggtggat catgaggtca ggagtttgag accagccggg ccaacgtgat aaaaccctgt 115200 ctctactaaa aatacaaaaa attagccaga tgtggtgcac acctgtaatc ccatctgctc 115260 aggaggctga ggcaggagaa tcacttgaac ccgggaggca gaggttgcag tgagctgaga 115320 tcgcaccatt gcactccagc ctgggtgaaa gagcaagact ctcacccggg gggcgggggg 115380 gggggtgcag tgggaaggag gtaattaagt taaaatgtgg cctgtaagat gggccttcat 115440 taaatatgac tgatatcctt ataagaagag gaaattagga cacacacaca aaggggaatg 115500 tgaacataca ttgagaagac actttctaca aaccaaggag agaagcctca gaacaaacca 115560 accctgtgga tactgcaaac ttgaacttct aacctccaga accatgaaaa aaaatatttc 115620 tgttgtttaa gccacctggc ttatggtatt ttgttacaga agccctagca aactagtata 115680 ctcaccgccc catgagctat agcctcaact ttcccctcct tatcatgagg accatgattg 115740 caactgcctt gtgggttgat ggggaattcc atgagatcat gcagtgtctg tcctggtatt 115800 tagtgaaatt gtcttcttgt taacattatt ctcactatca ctcctatcat actacctgtg 115860 tttaagtgac taatgaaaac attaaataca acaaagttaa tactagccta attttgtgtt 115920 acttcagaat ctgtaaggtt gactttgacc cattcctaaa tacttcttca gaacagtcat 115980 gcttatggct cacatcctta ttaccaaacc ttccttaccg aagctcatat ttgttgcctc 116040 tgacattcta gtttactggc ctcatacttt aaaagtatga gagaaacaat aaatatgtaa 116100 attattttgt ttttaaatgc atagagttgg tccaaatatg caaacataaa aataggtctt 116160 taggtagtga cttggggtca taggtttact ttctatgggc taaacatttt tctgatggta 116220 acaggatcat tccataatat tttgtaacaa tttctgtttt gggctttagt aatcattgag 116280 caagttgcat gtgctatatt gttaacattg tactctaggt gccccaaaat atgcaaatac 116340 tctaaatcta ctgatttgaa atctggggta ttgtgagtcc ggggtcttgc tcccaccccc 116400 tcctctcttg cagtttgtgt tgccttggca acagtcttcc agcacatcac atcaggtggc 116460 ctcttataga gacagcatca tgggctggac agcgtgccag gcttgtggcc ctggggcatc 116520 cttgatagat gctatgggcg ttattttctg cttataaaat cttagaacag ttatgtcttt 116580 acagataaga tttgattttt atcaaacggt ggaaaatgct gtgactggca cggtcttcac 116640 actctctctt ggaaatctgc gatcctgggt cggtttaatt taaaacattc cagtaataac 116700 tttcagactt tacaactcaa ttttattttg agaagtcatc atgaaggaaa tatttaagaa 116760 gtctcattcc tttaagttta aaaatgttcc acaggattca tttgcaacag ccagccactc 116820 accccaaccc caaacttcca gaaaaaatta tgcctccagg acatttctcc aaatgaagtg 116880 tcaagtccaa atcaagtcaa atttccaatg tggaataatg gactctattt tatgacctcc 116940 tgcgccccgg aggctcttcg gagcccatta cacagctggt gcatattagg tatagaagga 117000 aagagacctg agtggctacg ggtttctgct cggtgaagcc caagccacat ttcataggtt 117060 ctgggattat taatggtatg tctagttgcc ttgagaatgt tcaactccag tctgttatga 117120 atacttaata gcaaggagaa tgtgattctt ctcttttcag agacgtttct gtgactcggc 117180 gaattcattc tagtgtgata ggcaaactgt caaaattaat gaattccaac tgagatttgg 117240 ttgtagtgca gttgtaaatt agcattaata ccacagtgta tgttgaatgt gctacatttt 117300 caccatggat ctggcctaga ggatgtcttt ggaggaagcc actctaaaaa tcatgttttc 117360 tggtttggtt ttttcaattt ttgatcatag ttttaattct ggaagaagta tatgaaagta 117420 ggtcattaag attttataga acacaacaaa aaaagaaaca ggaaataaat gttataacca 117480 aagacatgtt agcagagttg tcttgttttt gtgtggctgt gacttaaaga tctgattact 117540 gaacctcaat ctatctaaat gttaagtgat tacaaaggaa cacgattcag tttataaggc 117600 tttagatgag ctccaaggac tacacggcat acctagccca agcacatctt attatgagaa 117660 ttttaaataa tctgcagcaa tgtttagatc aaaggtgttt taagtgggga tttggacctt 117720 taaggagctg gaaacagaac tgtgtgtgtc ctttttgttc atgacagagt gcagcacttt 117780 cttctcattc ttaaagggtt ctgagcccaa acacagtcac tgcttaactg acaacctagc 117840 accaaatccc agctctgttc ctcacgacag agttcaaagt ttatatggtt tctcatctct 117900 gacataaaaa tagcagcaat agcagcctgt gaggtgtagt ttgaggatta aaataaggtt 117960 ttgtatttag attacttagc ataatcctag cacataatgt gtattccata aaagctaatt 118020 atttaatcat gccaagaaca gaagcaatag ttacagcttt gaatataaag tttgataatg 118080 cacttggtga tattttcttg gcagacacgg ggctagcgac ccatgtcagt ggagattgaa 118140 atattgccac gtgtagatgc attaccactg agtgaaggag cacacttggg catcttggtg 118200 ctttgctgac acacaatacg gaatccaggg taactaattt ccttctcttc tctagagctc 118260 tgacttctca cctagtgcag tctgtaagaa taaacatcta taggattaaa tgtgacaatg 118320 atgggtgaaa atgcttggga agggcctaag gtgctgtgca aatggagagg cggcattcag 118380 aatcatttgt agtgggctag gcatggtggc tcatgcctgt aatcccagca ctttgggagg 118440 ctgaggcagg tggatcacct gaggtcagga gttcgagacc agcctggcca acatgataaa 118500 accccgtctc tactaaaaat acaaaaaatt agccgggcgt ggttgtaggt gcctgtaatc 118560 ccagctactc aggaggctga ggcaggagat ttgcttgaac ccgggagacg gaggttgcag 118620 tgagtcaaga ttgcaccact gccctccagc ctgggcaaca agagcaaaag ttgtctcaaa 118680 ataaaaaaaa aaaagaatca tttatagtga atgtttaatt ttaaaacact atatgtcact 118740 gagacttatt gatatttaat tgaatttagc ctaacagtct tgtgttcaag aagtattaaa 118800 tatttgttga gactctttgc tacatgctag aaactattgt aggaattggg aatacatcag 118860 ggaataaaat caaccaaaat atttactttt tagggaccaa aattttagga taggtttaga 118920 ggcagacagt tgaagcaagt ataacaaata ggtaaatgat cgagtgcact aaagacgctg 118980 agggccatgg ggagtaagtg caggcgtggg tcggaggggg cgctgcagta gtggaagtgc 119040 cgccatcttt accaggcagt caggggaagc atccctgagg gggagacggc acagccaagg 119100 ctggaaaagg tgagccaggg agtttctggg agaaaaacat cccaggtgga gggagagcag 119160 gtacagagac ccagaggtgg gagcctgcag gggtggtcta gagacgacaa ggaggccagt 119220 gtggctgcgg tgggatcccc aggggagggt ggtaggagat gacatcagag aagaaacagt 119280 gaggatggat cctgtaggaa gataggcttt tacctggaga atggggtcct caaaagctca 119340 gaacagaggc cagagatggc ctgagccatc ttaactggat cactctcact gatggagctg 119400 atggatgaga gtgtgtgtgt aggggaccag ggtagaagca gagagaccca ttgggcacca 119460 gggagaggtg atggtggatt ggaccaggga gtggcagagg agatggcaca aggcagatgc 119520 agggtatatt ttgagggtac agctaagaga cttattgatg ctgtgaatat aagatatgag 119580 gaaaacaggg acctctacaa gcacccacat gtttgggttg ggcaactgtt aagaatgatg 119640 ctttttactt cttcgattaa aactctcata ttttaaggat atttttgagt ataccttatg 119700 tgactcttat taattttttt ctgaagtact aacaaatgtg cagaagaatc acatacatga 119760 ggaggaaggc aagaaaactt cttgaagttt taagaatact ggatcccaga acaggggcat 119820 agctaagtgg acaaggaaat taggacaata atttaaccag ggttccaatc aacagatttt 119880 ttaaagtctt gcgtgtttga gactcctaaa taagcctctg taggcgagat ttcagcatcg 119940 tgtgttttcc atcattgaga gcctgtgggg cgtcattagt ctccagctga ctgatgtagg 120000 tgagaatgtc ttattttgtt ttttgttgtt tgtaacagaa tgcctgacac tggtattata 120060 gagaaatgat atattgattt cctccaatta tggaggctaa gaagtccaag gttgaagggc 120120 cacatttggt gagggtcttt ttgctgatgg ggactcagag aagagggggc tgggtatgcc 120180 agctcagatc tctcctcctc ttcttataaa gtcaccagtc ccacttccat gacaacccac 120240 ccactaatca attaatccat tactccatca atccattcat ggattgatct attcatgagg 120300 gcagagccta catgacccaa taacctctta aaggctctac ccctcaatac tgccacattg 120360 gggattaaat ttcaacatga gttcgagtgg gggcaaacat tcaaaccata gcagagaatc 120420 agacaaattg tgctgcgtcc acttggaagg cactgttccg catagggttg gtttgggctc 120480 cttctgatca tgattggaat tagacaaact ctctggaaac acactcactt acagactttg 120540 ctttctgtga gtattttttt ttttcctgtt aaagctgact cttctatgtt cagacccata 120600 tttttaagtt atctttttac actgaaattc ttaatctttc aagtttagat atggatttac 120660 cttgatttta tggactgtga atgccctctt ttcttatctt tttctatttt atctatataa 120720 tgatactacc atttggggtt agatcaatat ttatgattta cattattatg actatgtaaa 120780 tattagctac agctgagcca catagtatat gatgaacact ttttctatta cagctttgtg 120840 tttttcctag gattaataat cacttgcttc tttgtttact tagttttcac tgcatgtgtt 120900 actaattcat tccccaaatt ctccaacgga ctaaacactc ttcttaatac attcagatgc 120960 attagcgtgc ttgaatgttt atttttttcc tggaaacatc tctccaggag ccttctttct 121020 gctttaatct ggactgattt ctgctgtatg tttgttgttc tgttatcgtt cacagttatt 121080 ctggaaattc tttttgtttc tcacctatgt tgtaccgtct gttttctgga tatcgtatgt 121140 tctttctgag tttgcaacct tttaattcat tttttaattg ctttttgaag aagggtacat 121200 gagaggtcaa aattttgact ttgcatgatc taaaattgtc ctcgtttact tgtttgatac 121260 tttgagtatg gaattctagg tcagtcacac cttgctttat aaatggctgc acactgaggt 121320 ccagaaaagg caggcccttg gtctccacac tcctaggtca gaacctgaga gcaggttcca 121380 actacagaga accccagaaa tgatggcacc ttttctcaca aagaaatgct ttttccacct 121440 ccacagaggt ctgccttcgg ttacatttaa gtgttgattg cattgtccat acactcagtg 121500 ctgtgtgagc acacggttta caaggatgac aatgccccct ttgctgcatt caaggtacaa 121560 atgttttggc aatgaataaa gtcacatata cgaacagtct gttgatatgc aagggcaaaa 121620 atacagaact ggatcaggtg gtatgagtac aagggatggt aaagtcaggt gagtttcatt 121680 catgcagtat tccccaatgt cctctgggaa gatagaagag tacctcatac ctggagcccg 121740 gacgcaggtt tttttttcca tcactgcttt ggcgacagta ggcattgctg ataagaaaag 121800 gcaactggac atctacactt tgtcattgct tcctcatcct gccacagaag cttcattaac 121860 atggaaataa agggatttac aaacactcta aggacaaagg ggaagagaga tgagatgctg 121920 gcagtcatga gatgccaatg gcaatggatt taacattgtg gagaaagcca aaagaagtca 121980 tactagagga agccagtgag ccagtctctc attcagagca aaccctggaa aggctggtaa 122040 attcgaggga ccagattaga ctggagtcaa tccttaaaga gtctttcaaa gtttttttaa 122100 aaattgtcat cactcatgac ttagggtgta tttgcattta tgagaatggt catttatttt 122160 gtttctgaaa cttaaacctg tgcgttacat gaagaaagaa attacttaaa acattagatt 122220 tctgtaagtc cttaggtcag agcaaaatga aaaatgaagc acttctgaac atagtgaagt 122280 tctagcaaaa gaaaataatg ctcaacagtg tattagtcaa tgaaactaag aagaatttat 122340 gtctttttgt catttcactt cagtgttttc acttaatgct ggagtgaaag gtttaattac 122400 cgaacttgga ttttacattt ttatgctgag gtaccagtca gtctctggtt ataattcatt 122460 ttcttcttta atcataggag aaatgattca gttggctttg gttaacgtcc tcctcccctt 122520 ccctttgata atcttacttt attgttgctt cactgttttt ttgttgctat ttcacattgc 122580 catgtttttg gacattcaat tttgtaattt tttccctctc tctccaactc tttgcctctt 122640 aatctgcaga aagcaattct gttaacatta ttgtgatgtt atctttattt ctctgttatt 122700 tctgctgatt ttcttcattt gtaattcttt acataactct gtactctttc ttcattcgtt 122760 tgttctattc ttgttcccca gtttttatgc ttccgaatcc taaggagcca tttacatcat 122820 tttggtttat tcatgtgctt tactgcctgt gatcataatg ctcactgggt cttctgctcc 122880 ttccaaatcg ctagccactt tcatgccttt tgaaaccttt gagcttaaaa tgtaaatgcc 122940 ggaacgtagt aaaccacata catattattc attacagatt ctatattcct ctctgaaaat 123000 gtacacttaa cccctagcaa tgttaatgag agtgacttta atccatccaa agggatggag 123060 agacttttat ctctaaaatg aattccctat acacatatgg aagtagtact ctagaaatgg 123120 attgcaaaca atactcagac attttctggg taaaacacta atttattttt actttttttc 123180 tccagagctt tgtaaaaccc atggcaaaaa tcaggctttt tccttcttgt tgcaaaataa 123240 gtacaaatat tggataaaaa gaacattctt acacaaagta gctaaaatct tcgaagtgtg 123300 ttcttatagc acctcagaaa ttctttttgt cagccactca tccttgtggt cccttgatat 123360 ctatataatg gaatttagat tatagtagat gatgtatata aaatacagat tgttacttct 123420 taaaaggaat ctctttagtt atatgtagta tgaaaaccat aatatttttc ttttaaacat 123480 ttatttatgc attcaataaa aaatgtgagg gcttctatta tgtattagcc agcacaccag 123540 ctgcctctaa gaataagatt gcatcatctc ctatgaagca tgctgcccct cttctagatt 123600 gcaatggagt ggggtgcaca tgcaaaatag ctatgaaaac attgatgaca gtgtgatgca 123660 agaagctgaa aggtaggaca cggtgtctag tatgaaaggt agaagaccgg gaataaattc 123720 taaggaattg gtgtttagct gacattcaat gaatgagtag gagttaattg gataaaggag 123780 ggtgaagtgt tccagctaag agcctagtac cagcacagac cccgagttgg aaggggattg 123840 gggacctagg acactgagga gaccagcgtg gccagaccct agtgtatgac agctgtgaga 123900 tgacattgga ttttttctac tcacagtttc ttaacctcca acattcaaga atgcaaccta 123960 catctcaaca aaaaacactg ttacgttacc ctaatggtaa ttagcactaa aaaaaaaaaa 124020 aaagagcgag agagacccag ctctcagttc tccttttgga ttttatattt ttcactttaa 124080 ttccagcaga tttgcttcat gtcctctgaa gctcttttat taggtacata gacatttagg 124140 attgttatgt caccttgatg aattgaccac tttatcatta gggaataacc atctgtccct 124200 agtaatattt cttattctaa aatctacttt gatattaata taatcactcc cactttcttt 124260 agagtagtgt tagcttatat tttttctatt ttttttactt ttggtctatc agtttcttta 124320 taatagaatt tctcctggat agcgtatagt taggtattta ttttttattc aatctgacaa 124380 tgttttactt ttaagagtgt ttaggcaatt tatatttaat gtgatggtca atttggtttc 124440 gtttaaacct atcatcttgc taattgctcc ctattttttc tatctgtcct ctgttccttt 124500 atttttctct ttcttgcctt cttttggatt aatggagtat tttttaaatt gtcaatttta 124560 cctgcattaa aggattaaca tgtaagtttt gtttttattt tgctttgtaa gtggttgctt 124620 ttagagttta caatgtccat cttcaaagta acatggctta ctttcaaata ataccactta 124680 atttatagaa ggaccttaca acaataaatt tttatttcct ccttcctcct gcctttgtgt 124740 taatattgtt attcatttta tctatatgtt acaaaccaca caatgcatta ttattgcctt 124800 aacagtaatg tatcttttga tgatttaaag tgagaaaata tgattttata ttcacccaca 124860 tgcttaacat ttttgtcact cttcatttct ttatgaagtc acaaatttgc atctgatatt 124920 atttcttttc ttcctgaaag attttaacga tttttgtatt gctagtctac tgacaatgaa 124980 ttctcagctt tggaatgtct agaaagttat tttgtcttta tgaaaatttt tctgcatata 125040 gagctttagg ttgacagttt ttctttcctg tctttttttt aaaaaaatgc ttcaaatttc 125100 tctccccttg tcttctgttt tgcgttgttt ctgatgagaa gtctgctgtc attcttatct 125160 ttgtttctct aaatataaca tgtatttatt ttttaatctg gttgccttta agtttttttc 125220 tttatgttgg atttgaacaa tttaatcatg tgtcatgttg tggttttcta catgcttctg 125280 tttggtgttt gttgaatttg atggatagtt gaggttctag tgttcattaa agtttgaaac 125340 ttctgtatat taattgttcg attttttttc tgtatctcat tttcatccta gaactccaat 125400 tatacgtata ttaggccaaa cgatattggc ccacatctca ccagttttgt gtttactgtt 125460 tttaagcctt tttaaagttt gtttttcaat ttgggtagtt ttaattgctc tgttttctgg 125520 ttcattgaca gtttcttctg aagggtgtaa tctgccatta atcctatttg tctaactttc 125580 atttcatata ttacattttg aatctctaga aggtccattt gactgtttta tttgcagctt 125640 ggctgtttgt attttctcca tttctctcat caatgagctc ttcctttttc ctactgtctt 125700 gtacatattg acagaatatt tataagagtg atgttaatat ccatgcttgc aaattgtatc 125760 atctctcatt tatgtgtctt tctgtggaat agtttactcc taataatatg ccatatttcc 125820 cttattgtgt ccaatttttt attgaatgac agacattgta aattttatat tattgattga 125880 ttgttggttt ctattaatta tcatcaaagt tttttgttgt gcagttcaat tacttagact 125940 cagtttgttc ccttctagga tcacttttaa attttgttat gattaatttg tcccctgcag 126000 ctgtgtgata catttctgaa tactcaatct gatgttctat ttattagaag ttcttacctc 126060 ttttgctggt tgaaacatga actattttct cccctgtgtg agcttcacag attttcaccc 126120 acttctttct ggtgttccta atccaacctt ggtagttttc ttacacgcat gcaaatatca 126180 gcacacagtt aaggactcat caactggaag ctccttccgc tctctggagc tccctctcta 126240 tataacttcc ttctttccac tttgtaaatt ctagcagcct tagtcccctc aagtgtcata 126300 cttggtcccc ctaaccccac aatataacca agttttattc aaatttcctc cttttggaat 126360 tatcttagaa actcaggaag taagctgggc cactcataag gtccactttg tttgtttcct 126420 tctttcattt tttttttttc tgtactgtct gaaactttag tgaagacata gagtaaatcc 126480 agttcttgtt tctgtgtttt tgtttgttgt tttatgatgg acagagacag aatttcatat 126540 ttctaagtga tgacagttgc aacatcattt cacagcttgg gagtagatag aatgagtgaa 126600 atatattaac gttaaaggca aaattgctat aacatatgag cacattttaa taacctgact 126660 tggaatcact tcatagaagc cttggaatgc tttccaagtc attataagcc catcatttaa 126720 ctgatttgtg attgtctgat cgagatgaca ctgaatttct aagcatttat ccaaagaaaa 126780 aaccattttg gagtctcaga atcagctaaa tgttatgctt tctagatatg tttacctaag 126840 gctaagttat attccctttc attttggaag acctttacac aagcagttca ttttagtaag 126900 catacccact cacgtattcc tatgaaatca ataaagctaa cttgaaccca aatggcattt 126960 ccattcaaaa ttaatgtacc caatttgcaa attcgatagc ctgttttagt tctcatgttt 127020 tctgacctct ctgaagcaat tgacagtgtt gaaaactgtt ggttaacgtc tcaaaatgtc 127080 tttttgtttc taagacatca ctctctaggg tttgagctac tgatctccta atttcctatt 127140 tatctccttc atgatttttt tccaatttct ttaaactctt ttaatttttt aattgaaatg 127200 ttacatacat gcaaatcact gtgtacacat gcagtgtgcc cagcacccag atcaagaaaa 127260 agaacatagc ctgcaccttg gatgccacct catggccctt tccattctct gcacctgacc 127320 ccacccccac gggcaaactt tattctgact ctcaacatca tagattagtt tttcctattt 127380 tgatgtttga tataaatgga acaatacagt gtaaatccct ttggtgtctt tttgcttttc 127440 ttcaccatta tagttgtgtg atttataata ttttatgtgc agattgttca ttgttatcag 127500 tatgtagtga ttcaaggtgc caatatatca cgatgtatca attttattat tgatcgatat 127560 ttggtaagtt ttcagtttgt gactgttaca acgtgttgct gctgtagata ttccagcgtg 127620 tattttttga tggacatatg catgtgcttt tgttgtataa atacttagga gtgaaattgt 127680 tgagtcacag tgtacacatg tgttcccttt agtagaggct aataattttc cacaataact 127740 actgatttac attactacct gcattgtttg agggtcttgt tgctccacat tcttaagacc 127800 ctcaatatat tctgtctttt ccattgtagt tattttggtg gatgtgtagt agtaccccac 127860 tgtactttta atttactttt tcttaatgac cagtggcatt gaagcacttt ttaatgtgct 127920 tattggccat ttatatattg gcctttgtga agtgactgtt cacaccttgt gtgtgtgtgt 127980 gtgtgttttt cttctttgga gacaaggtct cactgtgtcg ctcaggctgg agtgcagtgg 128040 tgcgatctcg gctcactgca acttccaatt ctggggctca agtgatcctc ctacccctgc 128100 ctcctgagta gctgggacta caggagcatg ccaccacacc cagctaattt ttggtagaga 128160 gagtcttgct atgttcccca ggctgatctt gaattcctgg gctcaagcga gccacacacc 128220 tcggcctcca aaagtgctgg gattacaggc atcagctact gcacccagca cttttgtcca 128280 tttttgttgg actatctttt tatattggtg tgtaggagtt cattatgtat tttgggtaca 128340 aatcttttgt cagatatttt cctaccttat aaaatactcc ctatccctga ggatttactt 128400 ctggtttttg tctcttcttg ttctttacac ttgatatgcc ttggctgtgc cctcacccaa 128460 atctcatctt gaattcccac atgttttggg agggacccag tgggaggtaa ttgaatcgtg 128520 ggggcaggtc attcccgtgc tgttctcatg atagtaagtc tcacgagatc tgacggttgt 128580 tagaagtttt cctgcacaag ttcactccct ttacctgctg ccaaccatgt aagacgtgac 128640 ttgctcctcc ttgccttcca ccaggatttt gtggcttccc tagccatgtg gaactgtaag 128700 tccaattaaa tacctttctc ttgtaaattg cccagtcttg ggtatgtctt tattagcagt 128760 gtgaaaacaa actaatgcaa cacttttctt ggaatatctc acccagtgat agacttaaat 128820 ttccctggct gccaaatatg tctctagggt cttggactcc tatttccaat ttgctattgg 128880 gtggcccagg ggcagtgccc tctttacgtt agtgaaactg acatgttgtt tcctttacca 128940 accagctctg tcttgtaggc tctctttgta atagtgtaac tgtgcaactg ggtatgcaag 129000 caattacatt tgcctcctat tgactttttt tattttcttc actctttttg ctcccacatc 129060 cctgcccacc gatgctggta ggatcatatc agacatatcc ataattaggc cttttttctc 129120 ccttctcacc accaatgccc agctggccta gactcccagc agagcagtct agccaggctt 129180 tctgcctgca gtcttctctc cctgtctact cagtgtttac tttctcaaac ttcaatttgg 129240 gaaattgatt gttcattgtc aaaactttca ttgacttcct actttttaaa atagctttat 129300 tcaaatataa tttagatacc ataaaaagaa tccacttaaa gcatacagtt tagtggtttt 129360 tagtatattc acagataagg tgccttcacc acaatcaatt ttagcaggtt ttcatcactt 129420 caaaagaaac cctcctatcc tgtcccgtta cccagtccta accataagta agccactagt 129480 cgactttctg tctctacaga tctccctctt ctggacattt catacgaatg gagtcataca 129540 gtatgtggcc ttttgtggct gtaattgagg gtcatcccca ttgtagcttg tgccagttct 129600 tcactctagt ttattgctga gtgatatccc attgtaaggc taagccgcat tttgcttacc 129660 tgttcttcag gggatagaca tgtaggctgt ttccaccatt ggccattata cataatgctg 129720 ctttaaacat ttgctcacag ttttgtgtgg atgtatgttt tcatttctcc tgggtatgtg 129780 cctaattgtc cttattgtct gcagggctaa gcgcatgctt tttagcttgg cacctgacac 129840 tctttacaat cttgacttta taatcagcac ccttccacgc cttggttatt agtgtgtctg 129900 ctggtcttgg cacagtgcca gatacatggt aggtgctgaa gagtgtttcc aagataaatg 129960 aatctaagaa acctgtagct ccctctccta atcgtgcaac acttttagct gtgcattgaa 130020 tttcctgctt cccagcacct ttttatttct ctcctgactg ggacaactca atgtcctaat 130080 attttttaag acttctgcct agaatgtact tttctttcct cctctggaaa gttgtttcca 130140 tttttcatag gtcagattag tttctctatc acttatgctt ctgttgcatt ttgtgaatgt 130200 ttctgtcaca accttcggta aatagaatta taattgacct cactatgtga actagagtac 130260 ccttcagact gaaatttcct tggcagtagt accaggactt gttatatctt gcattactgg 130320 gcccttacac aagacctggt acctagtagg tgctcaataa atattattgc atcagtgaat 130380 gcttgtgtca ctgcctactg caaaattcct cccacatctc cccttttcac cctgccctgt 130440 ttgaatttta agaaaagcta aaatattgat ttattttctt tttggtgtaa cactcttctt 130500 tatgtttgtc agtggagcct tggttatgcc gtctgttaca gggatgtaaa atattgagaa 130560 gtctgcaact gaagaaacaa ttctccaagg tccctcccat tagctccctt agtgttggta 130620 ccccaggatt ttcaaccctg aatttcacaa gattgtgctg aatgtttcat ttagctttct 130680 gttttgaacc cacagttatt ttttaggaac tttcacacac acacacacac acataattca 130740 cattaaggtt gcctctgccc ttactggagg aagcaaatgt tactgtatta aagagcagga 130800 ggcactctat aaaaagaagt gctattattt aggcagatgg atggtccctt agatggaaga 130860 aacaaaagct gttggaatat agtttgggtt ttcttttgcc tgtggccata tgatgtgtct 130920 cttagagaat gagtttatgt tacattatta aaccctgtgg catgaaggag aaagactaat 130980 gtaaaattct ttaaaaatat aaggagaagt gacagtaatc ccccataggt cgcttatctc 131040 tttaactgct aggattaaac atttatttat catttttttc ctgcagtcat ttaaataatt 131100 tcacaagctg gcttgtggaa tgagattttc aataagaaac tatacattta attaagcaat 131160 gtttcttgta tacatttaca tttttaaagt cttgctattc ttaacaagac tacttttagg 131220 atacaagagg ataaattcaa atatgaccaa attttgctta gttcaaatta cccacagtcg 131280 ggttgataga aaaataatgt agggaaaaaa aataaaagaa tcctggtgga attaattagc 131340 cttgaagagt gacagttacc tcattcctaa caatatgttt ggggtaatgt cagtttcttg 131400 gaaagctcaa atgtaaaatt acagtgctac tatcagcatt tttatttgag ttgaaaactg 131460 ccgtgttgaa ctattaacta tgcttctgat ctgaaccgat ttcttagtta gcaataattt 131520 tcatattctg acttatgaag cattgctaaa gactttagtt atggttggga gagaaaacta 131580 taaaacactt acgacttgat gaacacccct gcctctcttc tctgtgggta agagctatcg 131640 cttgtacaaa atgtattttt ctctgccacc ttttggcaat tggtgttcac tgtgcttccc 131700 agcttagcca tagccccaac tggccctgga ggccaaactc ttggtttctg ccagtgatgg 131760 agaccaagag aaaaacgatg gatgtttcaa gtaagatacc tggaggatgc taaatctcat 131820 ggacacagct tcccctagat ctgactttcc ggaataaagg caggcatata atgaaactaa 131880 aatagtgatg tgaaaaggtt tcacctattc tgtatgagtg tgaagagtga aactttcgtg 131940 aattgttgtc ttggttcatt ttctgctact aaaacagaat acacagactg agtaaattgt 132000 aaacaacaga agtttatttg gctcatggct ctggaggctg agaagtccaa ggccatcagg 132060 tgaaggtcat cctaggtgga aggatggaag acagaagcaa gtgttcagga tagaaagaaa 132120 atggaggcag aatgtattat tttataagga gctcactcct gtgataatga caataatcca 132180 ttcatgaagg atctgcctct tacgagtcac cttttaaagt ttccacctcc cagtaccatt 132240 accctggtga ttaaatttca acgtgagttt tggcaggaac attcaaatcg tggtattctg 132300 ccctggcctc ctgaaacttc taacatacaa aatgcattca ttgaatccca gtaccccaaa 132360 agtcttaagt aattccagca tcagtttgaa agtccaaagt ctcatctgaa tcagatatga 132420 gtgagactca ggcatgattc atctagaggc aaattccctc cagccatgag ctatgaatca 132480 aagcaagcta tctaattcca aaattcgatg gtgagacagg aacaggatgg acattcccat 132540 tccaaaaagg agaaagaggc aggaagaggt aacaggtttc aagtaaatct aaaacccaac 132600 agagaaaaca accttaagtt taaagctgga taagaaaccc ctttaattcc atgtccctca 132660 cctggggaac actggggtgg ggattgggtc cccagggcct caggaaaagc tgccttggtg 132720 gctttgttgg gctcttgggc tcagtttacc cagcagctct catgggttgg agtcttatgt 132780 ctgcagctct cccaggctga tgttatgtgc tggtagctct acagttctgg gatctcaggg 132840 ccagccccac ttccgtggct ccactaggca ttactctagt ggacagtctc tgctgcagct 132900 ctggcccatt aattcgtctc agcaccgccc taatggggac tctttgtgcc ggctccacct 132960 ctaaaacaag tctctgccca gggccgcagg ctttctggga agtctttgaa gtttaggtgg 133020 agaaagccat gccccacagc ttttgcattc tgtgcacctg cagaattaac acaacatgga 133080 tgccaccaaa gtttatgatt agtaccttcc agagcagtaa gttaagccag gcctgggacc 133140 acttgagcca tggctggggc agctgaggaa tactttgtca caatgcagcg gataggtccc 133200 gagacagctt gggtagcaag ccacggagag tgcccaggcc tagttattag ctcatctagt 133260 tattagatta atgtctcttc tgcctctatt ctgctcccta cttcttcctt tattgtgaca 133320 atctaaagtt ggtgcttagt gtttaaatga ctggttacat gaccatttag tttcttaaca 133380 agatgtagtg ctaaaatgca tgagctcatt ccaccatacc aaatcttgac caccatatgc 133440 catcctcata actttctaac agttcttcct aatgaagttt tctttctagg ctatagtagg 133500 ccaggaatct cattacactt gcccttcctc atccccacac caacatattt attgatatat 133560 ttcctaacct tagttaaaga atgaagtttt gccatgtgca ctctaaggta tatttgtgca 133620 aggaaagaca gcaatccttc ccatctctcc ttagtgaggt taggggttaa ccttcttggt 133680 tttactaaat agaagtctac attccatata ggcacacgag agcaagtttc ctaatgtaac 133740 tgtgacacaa cacacgtctc aatgccctgc aggattgtgt gtcattgacc actgtgttta 133800 tactgataaa cttttctata attgaagcct ttggccctgg taacatttcc atcctatatg 133860 acaccagtga aaagttagag ttttcattgg tgccatatat ggcctaacag ccagagtgac 133920 cctcagatct caccccagta gtggacctgt caggtagata tcatctgcca acatccccaa 133980 ggaggtgtag gtcttcaagt gtgagatcat ccatgttatt tccagcattg ttgaacaaga 134040 cacttcttga gacgcacaga ttgacaatag cttttgatgc ttcccctgat caaggagaaa 134100 gagggtctta tcgggggccc atctactttg gagacatcta cattgtgtgt ccctcacagg 134160 ggagcagaat tcacatcagt atgtaggctt tcctgttcat agtggaaggg gggccacagt 134220 ttgtaagcat ctctctatat caggacctcg ctaaaggctt tcgcctgtac cccccacctt 134280 ctctctctct ctctctctct ctctgtctca acttctatac agtcagttcc taaactgtga 134340 gaggtaattc caatctactt aaaagagttg taattttgta aaatagaaat tccaaaaata 134400 cttcaaaagg ttacattata ttatcaacag aagtttgaca taccacatga attatgagat 134460 gggaaaatga aaaaatatgg ggacagtgaa tgcaccaact agcatttacg aaacacacac 134520 agcttgctag gcattaggct tagggctatg agcccattga atatgtgaag tttaactaaa 134580 aatcaaaatg tttatataat agataaatgt tagattcttt tttttttttt tttttttttt 134640 ttttgagacg gagtctcgct ctgtcgccca ggtcggactg cggactgcag tggcgcaatc 134700 tcggctcact gcaagctccg cttcccgggt tcacgccatt ctcctgcctc agcctcccga 134760 gtagctggga ctacaggcgc ccgccaccgt gcccggctaa ttttttgtat ttttagtaga 134820 gacggggttt caccttgaaa tgttagattc ttacatgagt atgttttcat aaaacaaact 134880 acacactgtc actgtccaga ttcaatgggt tcccaaaaac ataacagcct gagagtctta 134940 gttgtgtcat tgccttattc aatgtaataa ttattgcttg taaaaatgtt ttaatccagt 135000 gataatccag atttagtact ttcttccatc ttggtgtatt ttatttattg ctcatgctct 135060 attggggagc ttacatggga tgttagttgg cactttctga ttactttatt taaaatagaa 135120 aaacatttca gaaagacatg gttgtagagg gtaactagca gagcctcatt tgatgtctcc 135180 tgttgagtta cctgaaggga gatgctcaga ggaagagttg catgcagaag gcctcctggg 135240 agtgtattct caagagagac atcagcaagg gtgtgaggaa ggcagaatga gtggagggag 135300 aagcttctct gcaaagctct gatgatagcg gtctcaggtg ggatgcacct tcagcattgt 135360 tgcaacttaa cacgaggggg ccaggcttgt ggagccacct ttgaccagtc attccctgca 135420 ggcctcagac aaggcagttc cctgtaactt gggctggttc ccagtgtagg actcaacata 135480 ggatctttcc agctgctttg gggcagggtg cattggcgct aaagaggaaa tctgaaggga 135540 gccccacagt gtccaccaag tggcagcagg gaagaacatg ctgtgagtag agtcaaccac 135600 atctattcag ccttgtgcca atgcttggat gctgtgcttc ctaacagcag ggtggagacc 135660 acccgctacc ctcacattta gtgagcaggt taaatcttat tattataaga tgagtccaat 135720 cacctttgta aatagtgtta atttcttcat ctctttctta ccaaatcatg tcagttaact 135780 acaggcaaag tgaggggctc atgtatttta tcacatagac ttagtagcaa ccccagcaca 135840 tagcaggagc ctgtaacccc tcagctccac accacggaga aagactagat ctggaagcac 135900 aggccataga cccactctat acagagctgc ctgtaatccc cacacaaatg aggggggact 135960 gttatgccac atttggttct aagatgagaa aacaaaaatc tcaaaagcct tcatcagaaa 136020 gactgaatct agttctgcca cctcctagcc ctgcgttctt gctcaagtga cagcctgtat 136080 cctgtgtcct tggtcaagtg acagccctgt gaatctccat gtcaccgtct gcaaagtgga 136140 gcctttgttt acctagcgga gctgttgttc atctcgagtg ttagaaggtt gtctggtatg 136200 agatactatg aagcatacaa taaatgttat tctcacttct gaccagtgaa gttcattcga 136260 aatatctggg gcttctcttc tctcttacaa atatgtaact aggtatgcac ctgctttaga 136320 aagtcatgga gaagctcaga tgtgtgacaa gtaggccttc attatattta taaatctttt 136380 atttaacttg taaattctgg aagtcacgtt ttatttcttc acataaccaa cactccagaa 136440 acacttgtta taggccctta aatgaattaa aaagccaaat gtgtatgaac acatttgatg 136500 atatttactt gtagaagcga aaagagaaac aatttaaatg aaaagagcag aaaaacagtt 136560 cataagaata tgtataaatt gtgcattcac tgatatttac ttgtgaagtc cgtatagaac 136620 catggaataa tgtagatgat gtataaaaga attaaacagt tataaaaatg gtacatttta 136680 cgtatgtaca ctttaacatg atataattat atagataagg catggaggca ggtggaccac 136740 aagggaaatg taaaaatcaa aacagacact gtaggctggt ggagttgagt catgcttttg 136800 tcaaaattct ctttattgtt atgtcctatt ttaaataaaa gtgtattgtt gatttgacat 136860 tgtattttct gataatggtg cttttttaac atgctttact ctacaaagaa cttaaattta 136920 caagaaaaaa aaccccatca aaaagtgggc aaatgatata aacagactct tctcaaaaga 136980 agacatttat gcagccaaca aacgtgaaaa aaagctcatc atcactggta ttagagaaat 137040 gcaaatcaaa gccacaatga gataccatct catgccagtt agaatggtga ccattaaaaa 137100 gtcaggaaac aacagatgct ggagaggatg tggagaaata ggaacgcttt aacactgttg 137160 gtgggagtgt aaattagttc aaccattgtg gaagacagtg tggagattcc tcaaggatct 137220 agaaccagaa ataccagttg acccagcaat cccattactg ggtatacacc caaaagatta 137280 taaattattg tactataaag acacatgcac acatatgttt attgtggcac tattcacaat 137340 agcaaagact tggaaccaac ccaaatgccc atcaatgata gactggataa agaaaatgtg 137400 gcacatacac accatggaat actatgcagc cataaaaaac gatgagttca tatcctttgc 137460 agggatgtag atgaagctgg aaaccatcat tctcaacaaa ctaacacagg aacagaaaag 137520 caaacaccgc gtgttctcac tcataagtgg gagttgaaca atgagaacac gtggacacag 137580 ggaggggaac atcacacacc ggggcctgtt ggggttgggg aactagggga gggatagcat 137640 taggagaaat acctaatgta gatgacgggt tgatgggtgc agcaaaccac cacggcacgt 137700 gtatacctat gtgacaaacc tgcacattct gcacatgtat cccagaactt aaagtataat 137760 aaaaaataaa atgttttaca tatgatttgc aattttaatt aaaaatgtgg caaatttcat 137820 tgcataataa ccctcagtga agctagtaaa gagagcaatt tgatcccagc aacaagatct 137880 aggcattcac acattcagct tccctttact gagagtccag tgagagctgg gctctatgct 137940 ccaggtaata gtgggagtaa attaagacct tgtcctcatg aggcttatct ctagtggcag 138000 aagatagaca ataagtgaat ataaaatata tacagtccaa tggtggtcag tgtggggaga 138060 gaacagggtt tggggcatga ggcaaaaaaa caatctatta aaaattaaca tccaggataa 138120 cttaacagtt tgtgtacaaa atgtgaaatt aggatggtgc cttatttttt agtatcagcc 138180 tgtctgctca cagcattttc agaaaatttg aattatttgg ttttatttga gcctgcgcct 138240 catgattaat tttcaggata actttctgag gccagacatt gaactgcaaa tgtcaaaggc 138300 atgttttact cacctatgga tccctgtgtt gtcttcttgc agttttcagt gaagacctac 138360 actccagcct ctactttgtc aatgcatctc tgcaagaggt agtgtttgcc agcaccacgg 138420 ggactctggt gccctgcccc gcagcaggca tccctcctgt gactctcaga tggtacctag 138480 ccacgggcga ggagatctac gatgtccccg ggatccgcca cgtccacccc aacggcactc 138540 tccaaatttt ccccttccct ccttcaagct tcagtacctt aatccatgat aatacttatt 138600 attgcacagc tgaaaatcct tcagggaaaa ttagaagtca ggatgtccac atcaaggctg 138660 gtgagtacag ctctgggctt tgttttttct gtgcctgctt gggatgggag gataatgaca 138720 atgacacata gcaaaatgcc atcacagcag agaaccaatg aaaaccccat catcagttca 138780 ttctgacctt gctgatgact tctttaaggt ctccttgttt agatttcaaa gtgccttaca 138840 ttgttggaac taaaccttga aagaaagcag tgattagcaa gttggcaagt tctaacatcc 138900 cagcctcctt atattttgtc taatttgata ctctaattca aattttcagt gtctcaaacc 138960 caatgtgttt gcttccaccc ctcctttttt cccacttgcc cttcccctac cccatcctag 139020 gggaggagaa agagagagaa aaaaatgaca aatggttgag ctggaataaa accatagcat 139080 caagatgtac tgttatggaa acagaatcaa tctaatatcc ttgctttcct tgtgaaatag 139140 aaaggctatt ttaacatttt tgactgtatc acatgttgct gaaatgttgt cagtacataa 139200 atcctgaatg ggctatgttc cttttaacaa catattgtgt ctttttttaa tcaccattgc 139260 tacaagtcaa cccaggaaag aatactgcct gagatacaca gacatcaagg gctatatata 139320 caggacagat tgtgtggttc tatagattta acaaagccct gcaaaacaaa ctcacagcta 139380 gactcctgtt agcaaacagc attttaattt ttttaagtct agctctgaaa tacttgtgta 139440 gactgacata atataatagc agggcaaaga gaatgtgact ttgatttttt tcttatacac 139500 caggtagctg ggggagcttt gcaataattt cttcagtaag tgagtaggtg ctggtagaag 139560 acatcacaac atgagaaaaa tatgaggtgt ttctgaattc ctgcatatga tctctttgat 139620 gtaagccatc aaacattaga ctatgactca tgctgctagc tagtcatttt cccaactata 139680 ttttgatctt tgtgacatgc tcatgaattc caagacctgc atgagaattc acataagaaa 139740 gaaaaaaagg attgtcttta atcaagatat atgaaaattt gatgtgtcaa ataattacaa 139800 tgcaatttgt atagggacct ctaaacctga caaacaggga gatacagtga atgactttta 139860 ctgggaagac tgcacatttt aatgatgtgt tataaaagcg tatttataat ctgcaaaaca 139920 ccacttatag ggaaacctag aatttcaaac agctccatct gtgcgtatta atccattatg 139980 tctgccttgg attttctgtc agataaagga atgaaatgct tactcctgtt ttaactatca 140040 tcttctaaat tagtcataga attcattgtt tttgcatgac actgaaagtt ttagagcatg 140100 gacattgcat catcttgtct ggcgtctgtg ctacctgcct cttcctaccc agttgtgctt 140160 ttactattta tgtgctggcg ttcttgacat ctgaaaccct atggactatg aatccagcat 140220 atggatgact actgtatcag tttgaacata taagatgggc agtcatatta cccaaatcaa 140280 atttctctcc tgatttcatt ttgcttttta ttgtgaacac ataatggtta taataatctt 140340 ttaggttgtt cactggatac ttgaaaatct tttttcatcc tgtttatgta aatatgagta 140400 cagaactgga agcttgttca aaaagacaga tgaagggcat aaatgctacc ctttgacagc 140460 tgaagggtag gtttgagggt gatgactgct cactcacggg gtatcctctt ctgtatcagg 140520 tcatcctaaa tgtctaaata tccctgtaga ttggtgtttg gattttcctg gaataagcta 140580 ttaggtagaa tgacttcata atctttccct tggcagcaca agggattctc attcttaaat 140640 ttcagaaatt ttgacctagg tctgggtgct agcaattgaa ggaaggttta ctcatcatgt 140700 ctcattaatc atcaatccta gtcctaacat aagatatttt cttgcctgtt ctaagggctg 140760 gaatgcaggt gggccacttc agacagtatt gctccttacc caggctgcct ttgctacaga 140820 gcaagtagca atgagccgcc tgatcctggg caagtcagaa gatttctcat gattgttttc 140880 tccttagcag actgtgcttt ctttctttct ttctttcttt tttttttttt tttgagactg 140940 gagtctcgct ctgtttccca ggctggagtg cagtcgcgcg atctcggctc actgcaagct 141000 ccacctcccg ggttcacgcc gttttcctgc ccagcctcca gagtagctgg gactacaggc 141060 acccgccacc acacccagct aacttttttg tattttcagt agagatgggg tttcaccgtg 141120 ttagccagga tggtctccat ctcctgacct cgtgatctgc ccacctcggc ctcccaaagt 141180 gctgggatta caggcatgag cgaccccggc cacaaactgc tttctaacat ttgactagga 141240 cttttgcttg tggccgagat ggaggtgtgg gagccacatt taccctttta tctgaaacaa 141300 ccaaaaacca gtgtcctgag gctgataggg tttaactcta tgtccgcacc caaatctcat 141360 cttgaatgat aatccccata atccccatgg gtcctgggag ggacccagtg gaaggtcatt 141420 gaatcatggg gtaagtttcc cccattctgt tctcgtgaga gtgagtgagt ctcacgagat 141480 ctgatggttt tataagcatc tggcacttcc gttgcttgca ttcattctct ctcctgccac 141540 cctgtgaaga ggtgccttat gccatgattg tacgtttcct gaggcctccc caggcagttg 141600 aaactgtgag ttaattaaac ctcttttctt tataaattgc ccagtcttgg gtatttcttc 141660 atagcagtgt gagaatggac taatacaacc aactgaaaaa aaacaacgaa aaatgcagac 141720 aaaatatctg aagcaaccat tttcaagact ggacctcagg cagtagagga aagcattcct 141780 taaggagctg gaaataagat gtgtcctatg cttgccttat gctttgggat aaagaatatc 141840 aaaatctgca cataaatttg tatagcaact ttattcctaa ttgccaaaac atggaagcaa 141900 caaagatgtt gtttagtatg tgagtggatg gggataaaga atctctcctt gactaacttt 141960 ggaaaggctc ctctgagccc tcctctcaac tagttctcaa ccttagcttt tcacatctgg 142020 tctcttgtcc ccagctttag caagaatcct gctaaatcat ccccttactc ttgatacttg 142080 atcactctta atatctgatc aagttcttcc agtcccatct ttgatgtata catgtttggc 142140 ctgattttag caagaatctg ttaggccagt ttagcaagaa tcctcatccc ttgatgtctc 142200 ctctttctaa ttttccaccc actgctcccc tcactgtgtt cattggctat aaaccctcac 142260 ttatccttgt tgaatatgaa gttgaattac ccttccctgt tgcagtcatc atagatgact 142320 cctactggaa cagacatgaa tataatctta tctttttaat aagtgttaga acattttttt 142380 ctgttcttta atatttttga gaggacatct ccctctcttg tccaggtcgg agtgcagtga 142440 tgggatcgtg gctcactgca gcctcaactt ctgggctcag gtgattcccc tcagcctccc 142500 aagtagctgc ggctacaggc ataagtcacc acacctggct aattctttaa aaaaaaaaat 142560 tttgtagagg gtattctcac tatgttaccc aggccggtct caaatttctg ggctcaagcc 142620 atctgcctgc ctcagcttcc caaagtgttg ggattacagg aatgagccac agggcccagc 142680 tacaattttt ctttaacatt agacaaatta tagtataaaa tgaagtatta gtcagcgata 142740 gaaaaaatgt gctatcaagc tatgaaaaga tatgggggaa atttaaatgc ctgttactaa 142800 gtgaaagaag ccagtctgga aaagcaacat agtataccct tccacctact tgacattctg 142860 gaagagataa actagagaga cagtagaaag atcagtagtt tccaggggat agtcaggagg 142920 gagggagggt tgaacagacg gagcacaggg gattttttta gggcagtgaa actgttctgt 142980 atgatactgt aatggtgata cctgccatta tgcatagaac ttacaacata gagtgaaact 143040 tagtgtgaac tatggacttt agttaataat aataatgtat aaatatgagt ttattgtcac 143100 aaatgtatca cattaatgca agatgataat aatgaaagaa attaaaggat gtggcaagag 143160 ggagaatatg ggaacctgct gtgaactttt ctctaaacct acaactgctc taaaaaaaaa 143220 tcaagcttta ttcaaaaaaa ttaaaacatg cttcaggaag cttaatgaca aattaagccc 143280 caagggaagg gatggtgaaa tttaaaaaga agtggaaaaa tgcaggccaa aattttccaa 143340 atttgttgaa aactataaac ccacagatcc aaggagctca acaaacccca agctcaagac 143400 acgtgaagaa aaaatgcaca aaggcacatc ataatataat aaaattgctc agcgcaataa 143460 taaaatatca aaagcagcta cagaagaaag gcatattaca cacaaaggaa caaagataag 143520 aatgacagta gacaggattt ttgttgttgc tgttgggtgt gtgtgtgtgt ggatgtgtgt 143580 atatgtgtgt tttatgagac agggccttgc tctgtcaacc aggctggggt gcagtggggt 143640 gatcatcgct cactgcagcc tcagcttccc tggctcaagt gatcctccca tctcagcctc 143700 ccaagtagct gggaccagag gtgcatgccg ccacatcagg ctgattttta tttttatttt 143760 tgtagagatg gaatctcgct atgttgccca ggatggtcgc taactcctgg gctcaagaag 143820 ttgccctgcc ttggcctccc aaagtgctag gattacaggc aagagtggaa gtaaatttat 143880 aaaataatgg tgagatgaag gctttctcag acacaaaata gcagaaaatt tatcatcagc 143940 tgaatcctac tacaagaaat cttaaaggaa gttctagaat cagaagaaaa aaatgacacc 144000 tgatcaaatc ttagatctac tcaaaggaaa gaactgcaat gaaaatggta actacatgag 144060 tatctaaatc agatttttta aaaaattgca atattttaaa aaataattgg ctatttagac 144120 aaaaatagta acaatgtctt aggtagtttg taacataggc agaagtaaaa cttatagcaa 144180 caatagcatt aaggcctaca gtgaagacat gggagtgtaa tattggaggt tattttgcta 144240 tatgtgaagt tgtgtaatgt cacctgaata tagatggtga taagttacaa atgtatacta 144300 caaaacctaa agcaacctct aaaataacaa aacagagtta tagctaataa gcccacaaag 144360 gagaaaaaat agaatcatta aaaaatcctc aatccaaaac aaagaagaaa atgataagaa 144420 aaaggaaaca cggtaaaaaa aaaatacata tcaaatagca aaatgataaa cctaaccgta 144480 tcaatatcca cattaaattt aaatgttcca gtaacctgaa ttataaggca gaaattgcca 144540 gattggattt aacactgctt aaaagaaaca ttctttaaat acaaaggcac aaatagctta 144600 aaagtaaaag gataaaaatg atataccatc ctcatcaaat caaatcaacc taattaaagt 144660 aaaccactga aagaaagcta gaatagccac attaatatta agcaaagtgt atttccaaac 144720 aaatacactg tttgctcaga gcatcttgca ttagtgtgat acatttgtga caataagctc 144780 gtatttatac attattatta actgaagtcc atagttcaca ttaaatttca ctctatgttg 144840 taagttgtat gcataatggc aggtatcacc attacagtat cataaagaac agtttcactg 144900 ccctaaaaat cccctgtgct cagagctaaa gcagttcatt tcataatgta aaggggggag 144960 gtgaagagga tatgactatt gtaaatgttt atgtacccaa caacaaaact tcaaaataca 145020 taaagtaaaa atggatagaa ctgcaatgag aatcagacat atcaaaaatt atagccggag 145080 atttcaatac tcctagttca ataattggta gaagtagaca gaaaatcagt aagaacaaaa 145140 aaacacgtga atgacactat caatcaattt gatgtaattg acctttaaat aaagaacatt 145200 ctatccaaca acagcacaat ataaattctc ttctgagaca cacagacatt tactaatata 145260 gaccatactc agagcaacaa aacaaatctc agataaattt gttttaaatt caagttgtat 145320 aaaatatgtt gtttgatcat aatgaaatta aatcactaac aataacatct ctgagaaata 145380 accaagtacc tgaatactga atagcactct tttaaatgat ctgtgtcaaa aaaaaaaatt 145440 cagaaaaaaa tttgaagaag gaaattagaa agttttttca actgaataag aaatgaacac 145500 acaatatata tgaatttggg gagtgccact aaaaaaatag ggagatttta ttgctctaaa 145560 aaacttatat tagaaatttt taaaaaagtc ttaaatagtg gtctcagcat ccattttaaa 145620 ctgaaaaaga ggataaaact aaaactataa gcagaaagca aacaatgaag atcagaatgg 145680 agatcaataa attatagaac agaaagaaac aatagaggaa atctatgaaa ctaaaagttc 145740 ttttaaaaaa attgttaaaa ttggtgtgtt tttcaccaga aaagtgagag agttggtaaa 145800 tgactaatac caagaatgag ggagataacg tcactttatc ttctacaggt attaaaatga 145860 tactaagaga acattaagaa aagtagatga aataaaatat tttttgagaa acacaaacta 145920 tcaagactca ctcaaggaaa aacagataaa ctgaatagcc ctatatctat taaagaattt 145980 aaatttattg gtaaaaattc tctacagtaa aattcctggc tcaaatggct tcactattga 146040 attctactaa tcctttaaga aagaaataat aattttggcc aggcacagtg gctcatgcct 146100 gtaatcccag cacttttggg agaccaaggc aggagaatca cttgaagtca ggagttcaag 146160 accagcccgg ccaacatggt gaaaatccat ctctactaga aacacaaaaa tcagtcaagt 146220 gtggtgacac atgcctttag tcccagctac ttgggagact gagacaggag aattgcttga 146280 acccaggagg cgaaggttac agtaagccaa gattgtgcca ctgcattcca gcctgtgtga 146340 cagagtgagg gagactccat ctcaaaaaaa aaaaaaaaga aagaaagaaa gaataaaaat 146400 tataaacaaa ttcttccaga aaattgagga gagagtattt cccaaatcat tttatgaagt 146460 tagcattacc ctaatacata aacaagacat aagaaaacta aagacaagta tctcttctga 146520 ctatacatgt aaaaattcta aaaatttaac aaattgaatc caacaacata taaaaggaat 146580 aatacattat gaccacaaag gcttatattc ataatgcaag gtgagtttca catttgaaaa 146640 ttaatcagtg taaaccatgt gatcatttca acagacacag aaaaacattg atgaaaccca 146700 acatccacta atgattaaaa gaactctcag aaaaccatca gtagaaagga acttcctcaa 146760 tctgataaaa agcaactacg aaaatcctgc tatagcgaac atcatacttg tcaaagatga 146820 aatgttttca cccccaaatg aagaacaata tcaaagtgta tgctctcacc acttctattc 146880 tacatcgtcc tggaggttct atcctgtgca acatgacatg ctataagaag atgtgctgtg 146940 acccagacct tcttgtttta tttctagagc ataggcaaag tagatttgtc ataattaatt 147000 ctaagaaata attttagaat tattgaaatg gtaaatgagc attgacttca tcttagtcat 147060 cagctgcatt aacccttaac aagaatcagc ttgttttttg aagcattgag gctaggcatt 147120 gacttctcct ctctagctat gaaaatcctg gatggcattt tcttttaata gaaggatatc 147180 ttctgtacat tgaaaatata ttgtttaggg cagccacctt catcattgac attagctgga 147240 gcttctagat aacctgctgc agtttctcca tcaacacttg ctgcttcacc atgcatttgt 147300 atgttataaa gattgcttct ttctttaaat ctcagtagcc aacctctgct agcttccagt 147360 gtttcttctg cagctttccc acccctctaa gcctccctgg aattgaagag agctaaggac 147420 ttagtttgat ttaggctttc gcttaaggca atgttgtggc tagtttaatc atctctccag 147480 atcttctatc tactcaaatt ttctccacac caccagtaag gtagtttcac tttcttatca 147540 tttgttcgct gaagtagcac ttttcatttc cttcaagaac ttttcctatg catttacaac 147600 tcggctaaat gcacaaaagg cctagctttc agcctgtctt agcttttgat atgccttcat 147660 cactaagttt aatcatttct agattttgat ttaaagtaag agatatgaga ccatttcttt 147720 cacatgaata cttaaagacc actgtagggt tatttattga tttaatttca gtattgttgt 147780 gtctcaaaaa aagggatgct tcaggagagg gagaaagacg gaaaatggca tgtcagtgag 147840 gtgggcagag cacatatgac ctgtattgat taagtttgct atcttctgta aatgtggttt 147900 gtggctccgc aaaacaatta caatagtaat atcaaagatc actgatcaat gatcaccgta 147960 acagatataa tgattttaaa agtttgaaat attgtaagca ttaccaaaat gtgacacaga 148020 gacacaaagt gagttcatgc tgctggaaaa atggtgctga tagagttgca tgatgcaggg 148080 tttccacaaa tcttcaactt gtaaaaaaca taatctctcc gaagtacaat aaaatgagta 148140 tttcatgtga gaaacgcaca tacagccatc cagatgcaaa gaatggactc agagacacga 148200 agaacagcag aagcgactct tttttttttt tttttttttt ttttaagacg gattctcgct 148260 ctgtcgccca ggctggagtg cattggcgca atctcagctc actgcaacct ctgcctcccg 148320 ggttcaagtg attctcctgc ctcagccgca ctagtagctg ggattacagg catgcgccac 148380 cacgcctggc taatttttgt atttttagta aaaatggggt ttcaccatgt tggccaggct 148440 ggtcttgaac tcctgacctc aggtgatctg cccacctcgg cctcacaaag tgctgggatt 148500 acagatgtga gccactgcac ccagcctaag caagactttt gatgcaagat caggcgcctg 148560 ttaggcaggc acacccaggg caggtagagc aggtaattta ttgcctagca agcaagtccc 148620 tcccccagtt cctcattgat tgagtactat ggagttacaa tcttcctgga catcgcctaa 148680 gtttcattat ccccctttta aagttataac ccaatcccct tccccactta agttttgatt 148740 tcccagtaac aaaactttct tcccttttat gggctgaccc ctcgtctaca ttctgtttgc 148800 ttatcgtgac cttctaggtg catgagccat gcaatttgtt acatctgcag gctggctgcc 148860 agtgcttaga tttattatgc cttgaaaatg gaccatttaa aatgttttct cacattcgct 148920 gctgtcaatg tagaccaacc gtgtgatctc ttgctcaata aataagccat gtgtgtgtaa 148980 tcaaagtaaa gttgatttca gttttaaata acttcttata actataagat gcttttcgta 149040 agcttcatgg taaccacaaa gtaaaaacct atagtagata tgctaaaaat ataaagaagt 149100 atgaaagaaa ttgaagagga cacacacaca caaaatggaa agttatttca tgctcgttga 149160 ttggaagaat taatagtgtt aaaatatcta tactactcaa agtgatctac agattcaagg 149220 ccatccctac caatgacatt cttcacagaa atagaaaaaa aaatccttaa ctttgtatga 149280 aaccacaaaa gactccgaaa tgctaaagca atcctgagca aaaagaacaa agctgtaggt 149340 atcacacagt ctaatttcaa agaatacaac acaggtgtag tactggcata ctatagcata 149400 gtactgacat aaaacagaca catagaccaa tgggatagaa tagagaatcc aaatataagt 149460 ccatgcgctt atacccaaat catttttgac aaaggtacca tgaacacaca ttcaggaaag 149520 ggcaagctct ttaaaaatta gtgttggcaa aactgggtat ctatatgcaa aagaatgaaa 149580 ctagatccct gtctttaact gtgtatgaaa atcaactcaa agtgggcaaa atacttaaac 149640 taagtcttga aactatgaaa ttactgaaag aaaacactag ggaaacacta tagaaaatta 149700 gtctgggcaa agatttttgg ggtaaggcct caaaagcaca ggcaacaaaa gcaaaaatag 149760 acaaatagga ttacatcaag cagaaaaact ctgcacagca aagaaaataa aaatcagcaa 149820 agttgaagag acaacatgca gaatggggag actattaata tttgcaaact ctccatccaa 149880 caagaatata atgatggatg aaactggagg ttgctatgct aagtgaatta agccaggctc 149940 agacagacac acattacatg ttttcactca catatgggat ctggaaaagt ggatcttatg 150000 gaggtggaga gtggaatggt ggataccaga ggctgggaag caaggggatg aggagagggg 150060 ttaaagagta gttggctgag gggtataaaa atacagttaa atagaaggaa tatgttctaa 150120 catttgctgg cacagtaggg aaattatagt taataattta ttgtatattt ttaaattgct 150180 agaagaaaaa agatttactg tgctcccaac acagggaaaa gattgaagtg attgatattc 150240 caattaccct gattttatga ttatacattt tatacaggta tgaaaacatc acatgtaccc 150300 cagaatatgt acaactctta tatcacaatg aaaatatttg attaaaaaaa taaataggcc 150360 tgattttgtt tcaaagtcat attaccagag attttttttt cttctgatct aaaaagatga 150420 cagattttac tgaatgaagg ctaaaatgat tgcagtggac cctactggca tccctgaatc 150480 agatccccca agatctgcgc gctggttgct aagaacatga acctgcagcc ttcagaggat 150540 tgcttgggca ctggaaccat tcacagaaac aagagtggga aatgcctggg agttccatcc 150600 tcctgaggcc agccctaagc caatgacaga cagctacaac aggggatccc agctcctctg 150660 catgaccgag catgtcaggt gtggctggga cttcacctga aaccacacac ctgctttgct 150720 gcttccctcc ctgccctact cacactttcc ctgcctctca ggggattgtg tccttgctca 150780 gtcgcttgaa cccagctcct ccttttgggg tcgaataagg agaagggatg gggagtgtgc 150840 agttttcttc tgatccccgt tctctctgag cgagctgggg ttcagagcac cacagtgctg 150900 tccctgcttt gagaagatct gggctctctg gggagagcct aacttatgac accaagcaca 150960 gtacttagat aatactctgt cttataatgc aaatgtcaat caaatttaaa acaaagtgta 151020 tttttttttt tgcctgcatc tcaggtttct agcccagtgt ctgttactgc aacaaagtta 151080 gcagtagttg gatgtagaat gaagatcaag gctgcacccc tgtcttcggg gctgactatg 151140 ggctcaggaa actcacatgg ccctctgaga gatatatcgc catagacagc aatgttggtg 151200 tcttaagtta tggaggcctc aggaacaaac aatgctctat tacaaagatt aggagcttta 151260 ataaaaccct gatttgcatt tttttaaaaa actatagata gtggctataa attcaaatgt 151320 gcatacatgt atattctgta aaaggattag aagttctccc agaatggaag ctctgtcttt 151380 ctatatattc agtctcaaaa tatgtattga acacctcttg tgtgccaagt attttctaag 151440 ataatttttt aaaggctcac tgcacaggct atctttgtgg aatgagtaat cgaataagga 151500 gaagggatgg ggagtgtgca gttttcttct gatccccatt ccctttgagc gagctggggt 151560 tcagatcacc acagtgctgt ccctgctttg agaagatctg ggcttcttgg gactgacctg 151620 gaggttggag aagcaaaagt cacacaggtt taaaattgtg actactaagg tgtcctggta 151680 ctggtgaggg cagtgggtag ctagagagga gaaaactcca tgatatgtgg gtaagtgctg 151740 ggactgaggg gtttcctagg acactggaca ttgggtggta acactgggaa tgtccccggt 151800 cagtcacccc atatttttat ggctcctgtg atcccatcta gtgtaggctg tacacctggt 151860 gggaaggcat ttcccgtgtc tcccggtaaa caggtgaaca tcttttcttc tcactttcct 151920 gtctgataca tggaacttga cccctttcct tgatttctat taaaaattat cctacttgag 151980 tcattaatgt ttgaagcaga gtctgcggaa ggtttgggga gacagagtga ttttattgca 152040 aagaaacaag catcacacag acaaaggagc ttaaattgaa atcattcccc tgcttagggg 152100 cactattcct gtgacggtag actctctctg ttgaccagtc cctctttctc ctctgtcctc 152160 catcctcctc ttctcctctc tgtcttctgc ttctcaccat gcccagattc tcaccaatga 152220 gtttgattag tttgcctata tcttcatagt ctttttctaa tctattaccg tagacctcag 152280 ctcccagcaa aggtttactt atgcaggagc ctttctgtac aaagtcagtt ccctcctctc 152340 ggtgtaagga tgttgttgct gaggtcagtc tcttgggcgc cctgaatttt tgcctagtgg 152400 acctcctgca ggaggtgtgg agttgctgcc tggaccttca cctcatgccg cttggggatt 152460 acagtgatgg gggtcgcaga agatttcaat acttggaaaa atctctctgg ttagatacaa 152520 taatgaagaa attctccaag ttggggaaaa acggctaatg ttaaaaatgg aaactggaga 152580 ggaaggcttt catgaaagac atgctttact acaaaaatgc tcagcatatc acaaggttag 152640 cccgacctta acagtcctct tctaaagagc tcacctctgc ctactgggag atttcccttg 152700 agaaattcac ctttagcttt gttggtgtgt tagtaccttt tgaaaccatt ttcatggcac 152760 atatttgtcc agtaagtgat taattcttta agtgaggtgg ttagatgatt agacaataag 152820 ttatctctgt gggtatctta gaaaatcata gacttataag atttagacct tgaagaggtt 152880 cccaccacaa tgccctcatt ttaaatttga ggaaaacaaa gctctaaaga agtaaggctg 152940 gcacatctaa ttgggactat attcatcagt gtcttacttc cctggagaca gatcttcccc 153000 aaccctgggg atccatctct ggctattggt aagtgtggcc ttacccaacc tgcttctagc 153060 agacactgtt gaattttcac ctacgttaac tgattcacca cagtcaccct agggggcaga 153120 tgctaccaac atcatcccca tggtatagat ggtgagagga tttgctcact gccccacagt 153180 cagggagtgg ccgagcttgg atttgaaccc agggagttgg gcctgctagg taggttctga 153240 acaccagtac caccctgcct ctgagcctag acatcaagga cgtggaagtc cactctgcag 153300 tctttctggg atgctcctat cattggagtg tttgggcagg ctgtctaatc aacatccttc 153360 cctaaacaat gggaagcagg atcagtgttt cccaaactgc tttgcaactg tcatttaaaa 153420 atttactaat gaaaaattat tttaattgtc tcagagttct caaggcttcc cagaaaaatt 153480 gccttgcctg aattttttat tcattttttg cagtcagaaa aaaaaatctt cctcggccct 153540 tagaggacta atagcagttt gccatcatca taactttgca gagccagtaa cttttctttc 153600 atgaagctat ttcctatctc atgatacctt cagggggtct attaactatt ttcgattata 153660 ctctggcccc ttggtataga gtgtagtgta tttttttttc ttcacccagg ctgggtgcag 153720 tgatatgatt atagctcact gcagcctcaa cctcccaggc tcaggtaatc tcatctcagc 153780 ctcccaagta gctgggacta caatcacaca ccaccatgcc cagcaatttt tttgtatttt 153840 tagtagagat ggggtgttgc catgttgccc agtctggtct tgaactcctg ggcacaaggg 153900 atctacccat cttggcctcc caaagtggtg ggattacagg catgagccac cttacccagc 153960 tatgtattgt taagggaatg aatgttttct taagtcaggc gatgaaagac gtgaaatgta 154020 ggcatcttaa ctgttttcca gaaagatatg ttatgcaatt gatgtgtgtg tgctgcagtg 154080 tatatattac agtgagatac tctcagaatg agcctgttga ccgtgtgcct tactgacgtc 154140 ctctttctgc cttccagttt tacgggagcc ctatacagtc cgtgtggagg accagaaaac 154200 catgagaggc aatgttgcgg tcttcaagtg cattatcccc tcctcggtgg aggcgtacat 154260 cactgtcgtc tcatgggaga aagacactgt ttcacttgtc tcaggtaggc tttgcgtctc 154320 cagggtgcag gacaccacgc tcaccttctg aaaaggttat ttcagagatg gaatcgggtc 154380 tccgtttatg tgttcatcat aattcagaat tagtattctt aaggctgatg ctattttgta 154440 agtaaacctg aaataagtgt tttgtattgg cttataatgg cttgattcag acatcctttg 154500 gtgggttgac tgatgaagag agattagtta ccggcactgt aactgtagcc attgtgttaa 154560 cttttttgag aaaattgtgg ttttacgtct gcttctaaaa acaaggtagt agtattttgc 154620 atctgtgaga gacctcagca ttgcatatat agctgacatt ctgaaactaa aatctggaaa 154680 atggaagccc tgttttcatg accttttggt gctttccaat gtcttgagag ttatgttgta 154740 tctctgacct atttcttgaa gattctacta agaatatata tgtagcaatg aaatgtatat 154800 ttgcatatga ataatttctt ggcttatatt tggtgtgtag aaaagacaaa atttaaattt 154860 agcctccaag aaactgcagt tcttcatttc taatggtgtt gatttcttgc tctgtgctat 154920 ttacctggaa aggcgactgt ccgcgtgatg catggtgctc ctgttcttac atccttggat 154980 aatgactgtt ggcatatctc aaaatgtgtt ggctgctttc ggaaaagaat tgtgaggagc 155040 atagtctgtg ttccgatgtg gattataaat agttgccttt tttagacatg tctgtatgcc 155100 ctcacatgcg ggtgcacaca cgcacaacac acatgttaac agacttcttg actaagcaac 155160 attttatcca tttatagaga gcagaatttg gaactaaacc ctcacggtga cacaccgttt 155220 ttgtttctca gcttattgat tagctagaga ggttggttac tgtacaccac caccagaggc 155280 atttaaaaga tccaaatcaa agttgaaata cattgccatc atagcacatt acaggaatct 155340 aggatagaat ggaattctta gtttttatga aaacattgtc tttacagtga attcaaaacc 155400 cctcacactt caatgaacag tacattcctt gctgttatgt tgattaatta tcataattta 155460 acttagggtg ttgaaaaata ctaagcttaa taactcaaat gcgattgtaa taatcagaat 155520 agagactccc ttatacattt ttatttgcta attttcagtg ttgaaacatc ttcatcttct 155580 ctccttaggg gtcatgttag ttgtcttaat ggcaaatgga aggatttgat gacagtcatc 155640 tggctaagct cggaatcaaa ggggagaggc cctccaattt atatggcaag ggagtatagg 155700 ttcagggagt ggaagaattg ggagctacct tttcaatctt ccggactcgg tgacctagga 155760 tagagacttc accatctttt aaccctgtca tccaaatttt cagcttcatg gtctgctctg 155820 gcagaggaag agagcatggg agaattacaa acgccttctt agtgcttcca cttggaggtg 155880 acacatgtta tctctgttca tatttaattg gccaaagcaa gtctcatggc catgcctgac 155940 ctcaatgggg catgtgcctg aaggaagagg agaactggaa atctgggtga gaaattgaaa 156000 tatctaccag gaggattttt ttaactttta ttttaagttc aggggtacat gtgcaggttt 156060 tttacacagg taaacttgtg tcatgggggt ttgttgtaca gattatttca tcacccaggt 156120 gttaagccta atacccatta attatttttc ctgatcctct tccttctccc accctccacc 156180 ccgaagtagg ccccagtgtg tgttgttctt ctctatgtgt ccctgtgttc tcatcattca 156240 gctcccactt acaagtgaga acatgttcta ccaggaggat ttttgaatct ctttggttat 156300 gcataatacg tgtgttcttt tgtttttaga catctttaat tagcagcatc ctcattgttc 156360 ttgtttcacc tttttgcaat ctctgtgaac agactttatt ttccttcaaa tgtgaaccta 156420 actaaataaa aaaaaggaaa tgtgtatcta gtgaggggat gatgctggca tgcaatatag 156480 aatttatgcc cctctgatag gaactgttaa agcccatgtc ctctcctcag tcagatactg 156540 gagcttcatc ctttcataca attttaaatg caaaagtttt ggagaagtgc ttggtttgta 156600 cttcacaaca gcatctagaa aataaataca acacaggtgt ttatcttatt aaggaataca 156660 tcagtaagaa gctttggttg gtttgtaagt aaatcactga aagaaaggga gagagagact 156720 tcatatcagg tcgttcaacc tgagtcgaat agacttgtca ctaaaaatga ccttgtaaat 156780 gacaacaagg ccccaaagca gtggcatgat ctgctaatag aaagtctgga aattgagcat 156840 tttacctgac ttctgttgct cactgctaca gtcagaccct gttcccagtg tctgagctcc 156900 acccatcagc aatgcccaga aaaggaggtc atgaagtcac tggaggtgac gcatggttta 156960 aaacattgga gatcttaata aataaaccat gctcaggagg tttaggtgga gaagggttat 157020 atttctctct ggttaccagc acaaggcaca gataaggaca gaggacagcc tccctccccc 157080 atcacccagg ctgtgccggg gtggaggccg ctaaaaggaa gaccctccct ccctccacac 157140 tggctggggc tgagccactc cagggaagca ctgggattct tggcttcagg gaacgacctt 157200 gcatagcaca gaagtcccag gaacagaggg actttttcta aattagccct gaccttcagg 157260 gaagctgtcc tgaatgccat atgcacagca gatgacctgt aaaaggttaa tttgtctctg 157320 ctttgtatat aaactgtaac tcctgcgagc tagtttggat ttattccttg gcatggccat 157380 ctcccaggtc cctcttcccg gattatcaag tcatcccagc ctgctgggat ctggctggga 157440 agtttgttcc aggaagcatt cgtactctgc agagatcact tccttcagtg gttgattctt 157500 tccatggaga aaagcgatta actaaatcag ccatggaaat aagcctgtgt aagtatctta 157560 ctaagtgagt gagttaggag caggtatggg agtgccagag agttgaccta ggatagctga 157620 gagctgatgg cagtcaagag agggcccaaa agcatgattc acaggccatg gcccaacgtg 157680 ccccactggg ctcagggcga agtgtgacct gtcagcctgg gggatgctta gctgctcagc 157740 cttgactgtt gggagatccc ctgggaaggt cggagcagca aagacctgct tctaacagat 157800 gagctttggg tttctgtgaa tctctaggcc aggggacctt tggaaatcct ggtgaaggta 157860 aatgggtatt tgtcttctac aaattctttt ttaatgaaaa gcaaaattaa agatgtttgt 157920 gtatttccct aaaaagaagc aaaatggttt ctattagtat gtctcactag gttttgccct 157980 ttattttggt taagaaaaca aatgagtagt ttattttcct gagaagcaca aatgcagtgt 158040 ttgtcagggt ttaatgagtg ttgtgcatat tgtcatggtt ccttttggga gcttactgca 158100 cattagggcc tgcattgatt tctttccagg acaggcttcg gttggcctga aggtagacgc 158160 aggaatcaag ttatgcctct tcatcatatg aggccatgag gctaccatta tcaaggacat 158220 taatgagttc attgatttgg agtgaccttt ggaaagaata ccccaacagc tgaaaagtag 158280 aaatcccata attctaccaa atggaggaaa gattcataat atctgatgtt gcttttctgc 158340 ctgcctgagc tcttccctgg gccctggggc cttacagggt gacccttccc tctggtatga 158400 tggatggggg tggggtcgta aatgtgcaga ggaaaagcat ttcagagaca ggcacacaag 158460 gtgccatcag atgacctcag ttaatatgac agatcctgac ctattgtgtt cttacctccc 158520 taaaatgagc caggaagaac aagagtcatg atgtctatgt ggattttttt agacatcctc 158580 atcacttatc ctaagctgca atgaaatcct tttaaatgcc ataatattaa tgtagcccag 158640 taaaaatata gtagcttgaa taatgacatg cttttggagg tactgctgat gtggagatac 158700 ataaaacacc atcctggaaa aaaacaataa caccggcttt atatttgggt ttcccttcac 158760 aagcctgttg tgaatttcct cccgattagg gaggccagca gtaagagagc ccagccttcc 158820 gtttctgttt cttctgataa aattgtgaga atctcaccag gggtttagct acattaacat 158880 caaagacaca gcccaggggt aaccggattt ggaaaatgga aaaagcaaac attttactat 158940 tcccagagaa actgcctccc tctttagcag tggcccaatt ttctgctgta atatttccta 159000 tctgaatacc tctattagtg atgattcaag gagaatttta cctcttagga tcattgagtt 159060 caggtcgaag gatgattatc ttctttctgt attttggcta aacgtgaaca attttctgcc 159120 cacatgaaat atcaaaggac ataaaccaac cactttacat gaaacattgg ctgtaattct 159180 tcactgccac aactgggtct gggcatcata gatcacgcaa gacttgggct ttaagaagca 159240 ctccctcccc aggcccctgc agagatggtt tctgctgttg agatgcttgg ggagattcct 159300 gcactgtccc tcttggggtg ttaagtgctg cagtaggcgc ttagggcctg aggctgtagc 159360 tacacacacg gttttgcctg gggaagtaga gaaggtttca gaaaggaggt tgtgatttaa 159420 gaaaaccttt gcattttaga gaggggaaaa gagattatag gtacagccaa ccaaattaga 159480 caaggctgcc cttaagcacg tttcagcaaa ccagaactaa gagcagattg gatgccgtat 159540 tctcatgtgg ggagggaggg agagctagca cagctgtcgg ggggacctga gggtcatgct 159600 gtggggggcc tctgctttgt gcactcttga ctatagaagt taaccttccc tttctgtggc 159660 acttctattg tgattttatt gctcctcact gagcattttc cagacatctg ctatgctgtg 159720 gctgctatct tgcggagacc tgagtctgcc ctcaaagagc ttatgagtaa aaggaatgag 159780 ataaacatta aaataatgtg aaatttaaaa aaaacctaga gtcacctgaa agcctcatct 159840 ttgattttaa aagtgccaga gagttgcaga attaaagaag catttcttta acattcactg 159900 aaaagaaatt cgtgggacca aatgaaaagt ataaaaggaa catttttctg tctgttatca 159960 tctacctagc tatctgtctt tgtatgtatc atctaatctt ctatttatat tgcttttagt 160020 aaataagaac ctcattttaa acactggaaa gtattctcag ctcagaacgt gcacatcaga 160080 ctggaattag aaaggcacag agatgtcatg tttttaccat gctatatttt tgggagtgaa 160140 ttaactgaga aataggaaga gagggccctg gtctctttct ttttaaaaat cattaattat 160200 gttatacttt ttccatttaa gtctatcgct cactaaatta ggttttgcat gttaccccgc 160260 tgccacctga aagtaattaa aagctggttg tttacagctc tggagagccc ctgtgtgaca 160320 ccaagaatgg gggtcgtgta aggcgagggg cacagcctga gtctccaaac agctgccagc 160380 aaggctccaa agcagccaca atagcagcta gtctgcaggg cctcagcctg ccaggaggag 160440 acctgcaccc attctgaaag ctgcaaactg tgtattgtgg agtacaaccc aacacagaga 160500 agtacgcttt tgacttttga actaccaaaa caagtagata gacacataga gataggtatg 160560 ttaatatttt ttctttaaaa aagaaaacaa gaaaagaaag cattggggca aatttagccc 160620 agaggatatc aggaggggtg tgtgtacatg tgtgtgatgt gcgtgtccac atatgtgtgt 160680 ggtgtttggt gtggtgtgtg catacgtgtg tgtggtgcat gatgtgtgtt tgtatgtgtg 160740 tgtagtgtgt gtggtgtgtg tgtggcatgt ggggtgtgta ctctgtgtat atgtggtgtg 160800 tgtgtgtgcc gtgtatggtg tgtgagctct gtatgtgtgt ggggtgtgtg tgtggagtgt 160860 gtgctgtgtg tggtgtgtga gctctgtgtg tgtgtgtgtg tgtgtggagt acgtgctatg 160920 tggtgtgtgt gctctgtatg tgtgtgtgtg tgatatatgc agggggtgtg tgtgatgtgt 160980 gtgctctgta tctgtgtgtt gtgtatgtgt gtgtaaaacc tcatttgttg ggccactcag 161040 tcacactaaa atcccccttg atttcctatt ttaagtttct ggaatatgac ttgattgcag 161100 cgctgactca ggttagctgg gtggcctagg gaaaggcgtt tctatctctc tctgtttttg 161160 tttttgtttt tgtttttgtt tgcctcagtt tcctcccatg gatatgcagt gatttctcta 161220 gtcctctccc acaatacaat gccaggatat taaaattcca aattgaatat tccacttctt 161280 aagccaactg ctgtcaaagt tattttttca ctttcttaga tttaatcttg caggatgtta 161340 catgcccatg tcaaaggtcc ccaagcccac cctcaggttt ggtgatctgc caggaagact 161400 cagcatgtag ctgcatccat ggctgtgact taatacagga gaaggctatg gagcaaaagc 161460 agcaaaggca aaaggcacat gaggtgacat tcagaggaaa gcaggcccca gctctcaggg 161520 gtcttctccc tgtggaatca ctaggaagca cttaatttct ccagcaatga gtcatgataa 161580 gaggtgcaat gttgtctacc aggggagcag gagagctcct ggagactcag tggccaaggt 161640 ttcctttggg ggcaggtcac gtaggcaccc tggtatgttt ggtatgtgcc aaagttccag 161700 actccccaag gaaggcaggt gctcatcatg aactgtattg cttatgcagt tcaggcagtg 161760 agccactcta agggtggtgg gaacgctgcc aatatcctag ttcccagata ccagccaagg 161820 gacagtcctg caagcagccc ttcataagac tgacagtctc agacctactg tgttaactct 161880 tctctgtgcc atgcaacttt ttaaatgatg ttggctcatc ttcattttca tacattcaac 161940 gatcactttg catatgctca tcatgaaatg ctggagaaag caaatgaaga aaatctatgc 162000 tttatgtact ttattgcctt gtacccaagt atttcaagcc ttaagaaagg tctcatccca 162060 aattatttta aggtctgaaa acacattgac tcatactctt cccttgctcc acctaagtgt 162120 aaatggagtt cattttatat tctgccatta aggatcttct gctttctctc tctccccgtg 162180 atgtttggtt ctttctagac atgggaaaca gatggccagc taagtcaatc agatgtaatt 162240 tggacacaag catattctct ggtctgttgt tcatctaaga gttttcattt caggaaaatt 162300 caagagaata acaggatcat ttaggaaaga atattgtgta gtgataacca taatgctgtt 162360 agattattat tattatcgac aagctaaaat agatgtcaca aatcaagatt tgcttagaca 162420 atgtgccaca gtataagaaa acaggatttg agattgagaa atataatttt tgactcagaa 162480 taacttgcta gctactcaag aagtcagtgt gaactcaagg tattgtcgag cagagataaa 162540 ggtgggttgg accaggctta tggtgctgtg tcctttgctc tgggctggag caggtggagg 162600 aaggtctcct taagcagatg ggttgcttgg cctccagaaa tccctcaggc ggagctacca 162660 tggctgtcag ccctttgtgg ctgtccttct gagcagatgg ggcaggatgg agtaaaccat 162720 ccagcagccc agacttcctc tctcctcagc aaccgcgtca cctgtggaat cctcagtcta 162780 ggagccaccc cgcttccctt ctccaccgtc agcctgtgga gcgttcctgc agactgggca 162840 cattgagcat ttatgccagt ccggtttctt ttttcttttt tctttttttt tgatggagtc 162900 tcactctgtc acccaggctg gagtgcagtg acgcgatctc ggctcattgc aacctcttct 162960 ccaccgagtt caagtgattc tcctgcctca gcctccggag tagctgggac tacaggcacc 163020 tgccaccaca cctggctatt tttttttttt tagtagagac agggttacac catgttagcc 163080 aggatggtct cgatctcctg acctcgtgat ctgcccgcct cggcctccca aagtgctggg 163140 attataggtg tgagccaccg tgcgtggccc ggtcttaacc agctcttcac tgattgtctg 163200 gatgctcagg tgtttttgcg cccgcgtctg tatagctgaa gaggtctttc ccaagctttt 163260 tctcagcatc ctggagcacc ccattctcaa ctctgctgca cctactctcc agtgttcaaa 163320 ggatcgtaac ttttcactct gcaggggctg agaacagctt tcttcagatg accctttcta 163380 cctccttcat ggctcagccc cacgttctct cccacaggaa gagctgtcct ctttccttcc 163440 agcttagcct cccaccgtgc tgccctcctg gtccccttac ctgctccggc gttctaggac 163500 ctcttttcat cagctgtgcc ctctgttgct tcagacagct tctctttagt aattaccgta 163560 tttcttgtga cacaggtgct caggtccccc agttttaaag aaacctttcc ctttgctaac 163620 ttccatactt ctttctttct ctgtctttac tttcttcctt ccttctttct tttttctttc 163680 tctctctctg tcacacactc ctttcattct ttctctttct tctggcaaac tgtttgagat 163740 aatagtttat agtagtgagt attttgggct ttgcctgtta caatctactg aaattcacta 163800 cttcaagatc acccatgact tccaaatgtt aaatcccaag gctgtctcct ggtccagttt 163860 ctctctgacc tccctgttag atgtacacag ttgacctact tcctctgttg gttcctgtat 163920 ttggcagctc tggacgccaa aacaaaatat cacacactgg gtggcttaaa caacagcaat 163980 ttatttcctt atagtcctgg agcctagaag attgagatca ggctgccagc atggtcaggt 164040 tctgatgggg gcctcatcct ggcgtgcaga tggacgcctt cctgctgtcc ttacatgact 164100 gactttctca tgtttcttct tgcaaggaca ctaattctat ccgattaggg gccaccctta 164160 tgacccgatt taaccttaat tactttcata ctccaaatta cttctcttag taattactgt 164220 atttcttgtg acacaggtgc tcaggtctcc cttcccttcc cttcccttcc cttcccttcc 164280 cttcccttcc cttcccttcc cttcccttcc cttcccttcc ctcccctccc ctcccctctc 164340 cttccctccc ctcccccccc cctccgctcc cttcccctcc cctcccctcc cctcccttcc 164400 cctccgctcc cttcccctcc gctcccttcc cctcccctcc cctccccctc cgctcccttc 164460 ccttcccttc ctctttcttt ctctctcttt ctctttctct ttctttcttt ctctctttct 164520 ctctctcttt ctctcttcta cctttatttt cttccttcct tttctttctt tctttctttt 164580 ttctttttct ttctctctct ttctctcttt ctttggggtt agggcttcat catctacaac 164640 tttaggggac acaaggcagt tcatagcagt tgctctcctt tggtttgtat ccaactacac 164700 tgcctggttg atcttctctc tgaatatttc ggtgctatct ctttccttca gtttgcatct 164760 tcccctctca gaaatgtatg tcaatctaaa agtccaatcc catccacttt ctgtattggt 164820 catttcatca tcttccaggg cttcatccat gacttgcacc tgtgtgaccc caacttcgga 164880 cctgccttct ctcctggtcc tgcttattca ctcccccgca tccctctggc cacctccaac 164940 aaaggaaacc ttccccatga ccacaaagga atttcccttt gatttattca tttatttttc 165000 aatatcatga ctgtattagt ttcctaggac tacaaaaaaa aaataccatg aactgactgg 165060 tttcaaacaa tagaaattta tttcctcaca gttctgaagt ctgcaaatcc aaagtcacag 165120 cgtcagcagg gctgtgctga ctcagagggc tgcggggagg gtctctgtca gtactctggg 165180 gagggtccct gtcaggcctc ccagcacctg gtgttgcctg cggtccttgg ctccttggca 165240 tccttgactt gcagaagtct cactccatcc agtccctccc tctagcgaca tgtgactttt 165300 gccctgtgtg tgtctttgca tttcttctcc tcttctaata aagccaacag tcatattgga 165360 tgaagggccc accttatttc agtatgacct catggtaact taaatgatta catctaccac 165420 aaccctgttt ccaaataagg tcacattctg aggctccaga aaggacattt ttgggggaag 165480 ctatttaacc cactatgatt acaaattctt ccaattcttt atttgccctc tctcacacat 165540 tttatatctt tccatctcct gctggacaca cagtagacaa ctgataaata tatactcaat 165600 gagattctta aaaaaaaaaa aaaagcattt ttaagggaag gaaacaaaaa gcagacagcc 165660 ccatcagggt agccaggagt gctggtgtgc caggtcctgt gggtccctgc agccctgtcc 165720 ccggcggcgc cagcatccag ctggcagcca caccaccagc tgccgctgtc ccagctgcaa 165780 gtagcctggt ctgtgtcaga acgggctggg ggccagtagg ggacaggatc caggcagtcc 165840 tggaccaagc acaggggcgg caggcaagct gcttcacctg catttcagat cctcactttc 165900 gggtgccacg gtttattggg catcttcaag tcctgtgttt ccttcctcaa aaggaaaagg 165960 gggaaatttg ttaatggaca aacgactcat cagtttccca agtgattagt agtctgaaaa 166020 catgtgcatg aaaaaattgc ctcaaaagtt acccttgatt acaaaatcaa ttccaaacaa 166080 actgaatttt tattggataa actgtcacct gtggttgaaa cttcaacaac tagattctat 166140 ttgcaaagtt gtattgactg tccaaggctc atgtatgggg gaagtaatga gagtatttac 166200 agaatatttc agtgtgtgta gttcctgaaa atacagttat tccaaaatta attccaaact 166260 aactgaattt ttattggcta aatcgtcacc tgtggttgaa acttcaacaa ctaaattcta 166320 tttgcaaagt tgcattgact ctccaaggct catgtatggg agaagtaatg agagtattta 166380 cagaatattt gagtgtgtgt agttcctgaa aatacaatga tgctgctgaa aatattggct 166440 gtccagaatt ggactttatg agcaacagaa aatccacagc acacactgct ctgcagtaga 166500 gcagagtcaa aatgttcttt gaaaagaagc tataaacaga tacagtaaat aagcaaaaat 166560 acacagatcc tgtgtgctct tagaggtggt ttcaggtttc tgcatgtctt tcattttgcc 166620 agcagcgcac agcagggctt gggtttgcac tcagaggagc ctggctttgg gtccctactg 166680 cacagttgtg agaccttcca tagttaaata cctctctgtg gacctgggta ctgtgttttt 166740 ataaagatga agagtgccat aactgcagtt tcaggccaag tgaggtgctc catgaattgg 166800 aacatagcta agtaattctg gacctctagg tgtgcatttc tctatagagc ctgtagatag 166860 tgtggagcct gaagccagtg tctaggtcca taccccatat tcaacctgga ccaagttacg 166920 taaccttgag ttagtcatat aaccttgcta tgcctcaatt tcctcaactg taaaatggaa 166980 ataggaataa aaataacatt atagtaagat tgttataaga attaaatgaa ttaatatagg 167040 taaagttctt agcacagtgc ttgacattaa tgtttgtcat tgtccttctt cttcttatta 167100 ttattatcat tatcttctgt ctaaagtgtt tgtatcccag aaaccagaag gtcaggacac 167160 cgtggtttca aaacaaatag gccgttgttt gtgtgaggct tgttaggaag taaaagaaaa 167220 gtagttctat ttaagaattg ctaaaatgca aggtatgctg aagaagtcat ggggaaataa 167280 tccaaaatcc ttcaatttca acataaaagc attagaatgc tattgaacta atagtctgta 167340 ggattttaaa ataaacaact ctttacttat ttattaaaac gtttattttt cttaaatagc 167400 aaaagtatga tataaaatga caataaggca gaatgaaagg atcttatatt ttgccttaac 167460 catcacagct aaatcagagt atgtatttgc agtaaacatt agtatttaca ttaaaatact 167520 tgtagcacat gtcagttatt gaatagctaa caattctatg gcatgcacat gtcaggttat 167580 acctaaaaac ttctcgacaa ccccattaag taattgcttt tgtcggcccc actttacaga 167640 tgagaaggct gaggcagaga gagcttcagt aagtgaccca aggtcctttc ttgaaattct 167700 ccctctctag aagatagaga ttttgccttt tcttaaactt tctttcagtt tcccatatta 167760 tgtacgtgca taagagccaa caaatattgt cgactgaatg ataacattac cattccagac 167820 acatagtaga agcttaatac atgtttatgg agtgaatctt gaataagaaa cttttccatg 167880 agagtggtgg tgttatttcc ttttaaattc ttcttaatgc tttaataaga gcttttgctt 167940 ttctatattt ttttctacta ctctaaaatc aaatttcaca tcagcctctc ctcccaaggc 168000 aaagagtgcc tgtgttggcc aatcaggggc agcctgggat ttcatagctg acatctccta 168060 cgtgatgccg ttctgaggga aatcgacatt tcaaattccc agtatttatt attcccaaaa 168120 caaaagctgt cttcttttat tttcatgaaa tgattttatt gttggaacca cctacagctt 168180 tacactgcag catttgttaa aaagcaggac agtgcaagtc aaggcgaggc tgacatgccg 168240 agaccttcag aggcgcgtta cagcatttcc tgatgcactg aatccatagc cacaccacga 168300 gcctcagact ttactttcag ttttttatct aaagggttat acacatttgg tgagcacaga 168360 gtgtcaacct gccatggata gcttttgtgt gtgagggcat gttgtttcaa atagtgatca 168420 atatgcttca ccaatttatg atgatggatc taagaatggt agaatttctg tgtggagaag 168480 cttcagggtg tctttttgag ctggatactg gagccctgga aaggttacat gggggaaagg 168540 gatggcaaaa atgacagctg ctgagccaat cagatcaccc acacgcgccc atatgaggat 168600 gtaaatatca cctagatcag cctcccatct ctatcactgg ctccgatttc tcatcggaga 168660 attattttat agatgaagaa agcacccaga tgtgaaaagt cacctgagca gtgaatggcg 168720 gtgcagggac tccaacctgg gattttgtgg tggttgtgtc tgcactagtt ctgtgttcag 168780 ttgaaaattt ctccattact gtcatttaag cacttattct ggataaggca atgcttttaa 168840 agttgccatt ttaaaaatta tatgacctgt tttaaaaaga cacaaaagag atagaaacac 168900 gccagatata acctaattat aatcagtagg cttattatac tgaaggaatt acaaagactt 168960 atttttctga aagaagttca ttgaaaactg tacttcccaa aatgattcat tttgaaataa 169020 acttataact gagctttact tcaatatcaa atatttaaaa tatactttaa tgcaaataat 169080 atgttgtata tctgaaaatg tttacctgta atttctgaaa aaaaagtatt atatataaat 169140 attgtcttag attgtttggg ctgcattaac aagttaccat gcattgggtg gcttataaac 169200 gacagaaatt tatttctcag agctctggag gctgggaatt ctaagatcaa ggaggtgggt 169260 agatttggtg tctggtgagg gttctcttcc tggttcatag acagctgtct tctcattttc 169320 tcacatggca gaagaggcga atggtgtctc tggggtctct ttttagaagg gccctaacct 169380 cattcatgag ggctccaccc tcacgaccta atcaccctcc aaaggatcca cctcccgata 169440 gcatcacatt gaggtttagg tttcaacata tgaattttgg gaggcaggga aatagatctt 169500 cagtcgatat acatattttt ttaatagatg gaaatatcct taggccaatg tttcttgact 169560 ttttgggggg atcatggaca tgttgagtaa gtaataaaag ctatggggca gtggatcttc 169620 agaagaacac accagtatcg aaagctgcaa cagtccaggc cttttttgct tcctttcaac 169680 cttgtgacta tctgcattcc ctcacccccc ggctcccact tgtccttacc cagattaacc 169740 agggattcat actccattaa aatgcctgat atagatgttg gatcgtgtct tccttttttt 169800 caacctaaat tgcattttga aaccttcagc cacactcttt tctctgatct cttatttgtc 169860 ctggtttcct ctgcttcttt ttatgcacac attttttttt atcctcctat gcccattgca 169920 ttgtaccagt atctttcact acaattgttc ttgtaccagg aaaagtaaag ggtttttata 169980 aaaagccttc atcaagtcat tttcaaactg cagatgatac taggaaagaa aggccatact 170040 gagattcccc cccggctaat tagatggtga aatttttagt tctcagcatt gttatctgtt 170100 tgaattgaaa ccctatcatt gaaaaagcca aatgaacttg aaattgagga gggccatttc 170160 ccaaaacgga acgcagccag gctgaatccc tcggtggaga gccagggagc acgaggcccg 170220 gatgcacgtg actcgtttcc acagttctga tttccaagcg aagtaatttg ttctttaaaa 170280 aagttattct aggattcaag actttaaaaa aaatctgtat tgccaaatgc ttaccatgca 170340 tgatgaaata ttgaagaaag gtgtatctca gccttgcagg taatttttaa atgatccaca 170400 aggatttatt caaggtcagt aaattctgtg ttcgaacttt ccatgtcagt ctgtgtccca 170460 cactgtgtcc ccatcaagtc aattcctctg atgctgaatc tactctattc cttgcctcta 170520 agtaaaaaaa tttttaaaaa ttaaaaaaca aaacaaaaca aaaaaacaag caaacaaaag 170580 aacaatacgg caatcgaagt ctcaagcatt tcctctttta ctgaattcga cacaattcca 170640 tcgctaagta gagaaaacct gaacatccta ttgctggccg tgcctcccag ggttctccag 170700 taaacctttt ccatgaaagc ctgaagtcca tttcagatgc aaaacatgca gaacctctgg 170760 gctccgcgag gcctgatgca tgactttgat aggactctgc acatgcttag ttgatggtcc 170820 tgaacatgtg tattttcctg aatttcttgt gcttttttta ctggctttga cttgttgaca 170880 taagatgaat gtttctctct tgttttatca aaatatttaa gtgtttttag ttttgtattg 170940 agatttttaa aaacaaagct tttcttgcta gtaaggatat ggatgattac tttcttttca 171000 agaaaaatgg tgaaactgga aaagtaattt catgtattta aaatatacac ttgttgcata 171060 gttattgatc agtttataaa ttttacacct ttttggtggt gggaaaaata tattcatagt 171120 gacttctatc ttaaattctg gatctaagac gatgctgctt tttactaata gtggctatag 171180 agtatatgtg ttcttgtaaa atggttatgc agaaggagaa taggaaggac tatagatatg 171240 tgattaaaga tatttctctt ttgaagggtt agttaaattg aggaggcggc acgagggaca 171300 aacattgtaa actctgtgta acagcaagga tattcaaggt gacaaggatc agaacctctg 171360 tgaaggttca gtaaaattat ttgtgcacat caggttatta tataggatgt aaaaatccag 171420 ttttatggca agatttattt gtttatttgt gactaacata tacgacctga atttaaaaac 171480 tagaggcaac actcatagca atttagaatg cagcttttct tgtgatttaa attggactta 171540 tttttcttta gtctccaacc ctttcttaga agaattatgg tggaacagaa gctgtaaatt 171600 agggacagtt atttgaacct agttacagaa acgaagttat tggcgtgggg attctatagg 171660 agggactcta cattggatgg aaatgaagga ataactggaa gaagaaagga gcaaataggc 171720 ccaagtatac atttcactgt gtgaacccat aattctctct gatagctgca tgattaattc 171780 aaagatttat tgatttttcc cttctctact ccagcctgct gacctggttt tgttgacagg 171840 tttgtgtgga tcaagccaat ctgacagatg aaagtgtgct accatattag tccccgtggt 171900 ctggggcaaa tattttatac agtgtcctta tcaacagtaa ccgaacacat gtgaggcatc 171960 cgtcaacact ccttcccatg ccatgccatg aaatagactc agagatgcca gccccacagc 172020 agaagcagct gggattattc gttttaatga acatgcatcg tgtgtacgtg tgtgcgcgtg 172080 catgtgtgtg tgtgtgtgtt tatataatga ggtgggagtg tggaagttat ggcattttta 172140 ctcttagtaa caaatattaa ctgacagtta gcttttaaaa atacctttat gggccgggcg 172200 cggtggctca cacctgtaat cccagcactt tgggaagcca aggcgggtgg atcaggaggt 172260 caagaccatc ctggctaaca cggtgaaacc ccgtctctac taaaatacaa aagattagcc 172320 gggcgtggtg gcaggcgcct gtagtcccaa ctacccggga ggctgaggca ggagaatgcc 172380 atgaacctgg gaggcggagc ttgcagtgag ccgagatcgc gccactgcac tccagcctgg 172440 gagacaaagc gagactccgt ctcaaaaaaa aaaaaaaaaa agaaaaagaa aaagaaaaag 172500 aaaatacctt taatgatacc tgagatttac ttcaaaacaa tccattgcca ggggtgaggt 172560 tgtagcctga attgataatt tctgaagctg ggggatggta catggaggtt tattatactc 172620 gttatatcct tcatgtgtgt ttaaaatatt ctataatgaa aagttgagga aaaacaccta 172680 taagacaaat catatttttt acttgaaact tcagattaca tgtttaaaca tgagcaattg 172740 gcacatgacc aagccaggaa taggcagatt ataaatgtca tattttaaaa attaatgcta 172800 caacaactga agcatttttc tgttggttat gagctctaaa ttctggccaa agactagaac 172860 cacaaataaa atggtccttt aagactagtg aatcatctcc aagttgagtg tattccttct 172920 cagctaataa aatgagatat ttttgaccaa catttctcaa actgtgtcca tggagagatt 172980 aggaagatag ggaaaagatt atgtggattc tggttcaaaa aattttagga aataatacat 173040 taagcaatag caacccagtt ccatgcagca cgaatgtcaa agtgattgtg gccacttttt 173100 aaaaccaatt aaattagttt atttttattt ttattttctc tttttagatg tattagtcca 173160 ttctcacatt gctgtaaaga aatacctgag gctgggtaat ttataaggaa aagagattta 173220 accggctcac ggttctgcag gctatagagg aagcatggtg ccagcagctg cttctgggga 173280 ggcctcaggg agcttttact catggtggaa gtcagagctg gagcagaaag ttcacatggt 173340 aaaaacagaa gcaagagaga gtgagggagg agctgcatac ttttaaacaa ccaggtccca 173400 tgagaactta ccatctgaaa aatattgtgg atagtgctaa actattcatg ggaaatccac 173460 ccccatgatc taatcacctc cccaggcccc acttccaaca ttagggatta cagttctaca 173520 tgacagctgg gcagtgacac agatccaagc cataccacca gaccactcat gttattctat 173580 agaatataat ttagaaaaaa ctacttccaa cgtaaggcca ctagaggtga tttgcataaa 173640 attgaggttg tttaaggcct tgagttcaac aattcagggt taaatatgag ttagatgttt 173700 tcataggacc aaacaacatt tataggtctt gaataaatct gaaatttcta cttttataaa 173760 gtctaatatg tagatacact gggtttcatt ggattctaat tccatttttt gtattttggg 173820 gggggcatca tttttatctt tactaccgta aaacaagaca ccatcacagc caactccaaa 173880 tggccagctg tgaagtggaa ggaaagatgg aacaagaggc aaccaaccat gtgtgggtgc 173940 tcaggtggag gggactgtgg ttggtggaag acccctaagt ggagtgagct tggataggga 174000 gtcaggatgg gaggtggcca gggaagggat ggggcagggc cagcctgcat atgaagggcc 174060 ttcctggtta aggcaatagc tttggatttt tatgcaggga taatggcaaa ctgttgaatt 174120 ctgggctggg gattgatgtg actgctgttg ctgtgtggag aaaagtgcgg gggagagcaa 174180 acataccatt agatgactag taggaggctg gtggagactg acttgagtgg cagacatggg 174240 gacagagaaa aaaaggacag atgtgagaga tgtttgggga agctttggta tgttggctga 174300 tagattagat gtgggggtga gagaaagaca gtcatcaagg atgattcagg taaggaattt 174360 agtgcatgtt ggtaccatca ataggtgtgg aaactctatt atttaaggtt atcaatcaga 174420 aattgaatag cattaataat aggcaaagcc ctttaggcac tctgttcttg gtgtatatgt 174480 gtgtgcggag gatgtcctgt gagccactta ggctcactat aaatatcttt ctgaagcctt 174540 ccttgaatat actactctgg cctcctacct ttgctcaagc tgttttcttt tttctgtttc 174600 accttcagct ttatcttact catgctaggt cagacttatc actgacttca ctgcattttt 174660 gttggctgat ttccagttag tcaaaataaa agaaagtgga tagttttggc ctttgaagca 174720 aaaagagaca cagggacctc tctttccagc ttccaactcc ggatatagca gttgatggtc 174780 gacatctcac agtaattatt aggcactata attttgctaa atttacttaa gctaaactaa 174840 agaccaccaa gagcaccttc tacggactga tgttatgtcc ctctctaaaa gccatatatg 174900 ttgaagccct aacccccaat gtgactgtat ttggaagtga ggcacttaag gaagtaatta 174960 agattaaatg agggcatcag ggcagtacct aacccaatag gactggtgtc cttataagaa 175020 gtgggagaga caccagagag cttgctcttt ctctctctgc catgtgagga cacagaaggt 175080 ggctgtctgc aagtttggaa gagagccttc accagataca cagtggctgg aaacttgatt 175140 tcggactctg gcctccagaa ctgtgaaaat ataactttct gttgtctaag ccatcctgcc 175200 tgtggtattt tttgcagcag cctaagatga ctaatacagc acccttctgc tcttctgtct 175260 gactgtggtt tcttggagaa ctgctgtctt atattcttct tacttccaat ggtcattcaa 175320 tttccatacg gtttccatgt agtctaatgt cagttcattt ttataaattt aaactatttt 175380 tccatttttc ccatagtcat cctttttttt tttttttttt tgtttaagga atcatcttgc 175440 tctgtttcct aggctggagt gcagtagtgc aatctcggct cactgcaacc tccacctccc 175500 agtttcatgc aattctcttg cctcagcctc ccaagtagct gggactacag gcacacacca 175560 cccaccacac ctggctaatt tttgtatttt taatagagac ggtgcggggg gggagtttca 175620 ctatgttgac caggctggtc tcgaactcct ggcctcgtga tccacccacc tcagcctccc 175680 aaactgctgg gattacaggc atgagccact gtgccaggcc tctttgttca tgttagtgta 175740 tggagacttt tttatttgtt caggctagtc tgttcgcctt ttcttccttt gaagaaatta 175800 tctgttctcc ttataagttt tacagtgttc aaactttgga tcatgtcttt ttctctcttt 175860 gatctctttc taaatatccc tttatttaaa actgtgcatg gattttctcc taaaatcatg 175920 tggtgaggaa aatgaacttt tacatttctt caggaaagta aacctggtca aagactacag 175980 ttgggagaaa ttttagacac tcacgtatgt gactagactg tggatgtgaa tggtgtctcg 176040 ttaagcttgt ctcaggcttt catatggcaa agtagtattt ttaagttctt tttaggtcct 176100 gcctttacct caggatgcat tttcttataa tctgattaca atatttttta atggagacta 176160 ttttctcttg tacaagttat atgacaaaag tacatttggc ttgtcttctg tttgtttgag 176220 ttgattgtgt tctgattagg aatgctaagt cacctatgca aaagcaactg agaactaact 176280 taaaaacatg aattattggg gaaatgtttg tacacccatg ttcatagcag cattttttgc 176340 aatcgccaaa agataggaac agcccaaata tccatcaccc aatgaatgag taatgcaaat 176400 gtggtacata acattccctg gaggatttgt cagtcttgaa aagaaagaga actctgacat 176460 atgccacaac aatcttgagg gtattacgct aagtgaaata agcgtgtcac aaaaagacaa 176520 atactatatg attccactta tatgaggtat ctaaagtagt cacttttttt tttttttgag 176580 acggagtctc gctctgtcac caggctggag tgcaatggcg cgatctcggc tcactgcaac 176640 ctccgcctcc cgggttcaag cgattcccct gcctcagcct cctgggtagc tgggactaca 176700 ggcacacgcc accacaccca gctaattttt tttttgtttt agtagagatg aggcttcacc 176760 atgttggcca ggatggtctt gataagcagt caaatttaca gaggcagaaa gttagaacgg 176820 tggttaccag gggctggaag gaaagagaaa ttgagaaatt gtttaataag taccgagtta 176880 acaatactga actgtcctct aaaaatgggt aagatagtaa gttttatgtt acatgtactt 176940 taccacaaat aacttaaaaa acgtattgca cctcttctct taaaatagct gcatgggaaa 177000 attgatttta tttgtaagta aagacctagg tgaattaact tgaactagta ctatattgtg 177060 acattgtatt ttataaacaa cttccaaaat cataatcata attattttgt cctggtattt 177120 ttttaaagga tgtgtgtgat ggtattgaat ttggactttt ttttttatta tagccatatg 177180 ttgaaaaaaa tcaagcctta gaaaatgaaa agtatattgt aggcttaaaa attataataa 177240 catggtcggg cgcagtagct catgcctgta atctcagcac tttgggaggc ctaggcgggc 177300 agattacctg agttcgagat gagccctgcc aacatgatga aaccccatct ctactaaaaa 177360 tacagaaatt aaccaggcgt ggtggcacac gcctgtaatc ccagctactt gggaggctga 177420 ggcaggagaa ttgcttgagc ccgggagatg gaggttgcag tgagccaaga tcaagctgct 177480 gtactctgac agagcgagac tctgtctcaa aaaaaaaaaa aaatatatat aacaacattt 177540 gggaaaatag aatgatagta attttatctg tctttatatt ctttaacact ttggtgactg 177600 aattatagac aactagtgta taagctacag gaaagcagag attttggtct gttctgttaa 177660 tttctagaat agtaactggc acataggaac tccatgactc ttcatttaat gagtacacgt 177720 tgagagtatc caagtactaa ttactctttg ggcacgtgga ttgtggaagt gtggagacca 177780 gtccacagtt ctcctagata taaggagctt tccctgtgtc tgttgatcac ataattattc 177840 atcagtgagc tctttgttgc ttttgtatct tagggtaaat aatttaaaca gatcatatag 177900 ataagacact gaaaatctct ccactgagag gtggagagat tcgtctaggg tctcaaaata 177960 aatgactaac agaattgttc tctgttcagg acactaagtg atgcaagaaa tatttagtga 178020 ccaccgactc tgtgaaggtc ttgagcttgg ctttgtgaat atagctatga ataagagaaa 178080 tacgcaatcc ctgcactcaa ggaatttatt atctggtgtg tgtgtgtgtt tggcacggag 178140 gtgatataac tgcttcctga actcaataca atcttttcat tacagagcct cattttagcc 178200 ccaatttctg tatcttttct ttgttttttt cccaatcact atcttttgac tggactatac 178260 tactgaaagg aagtggagtc cttaggcatc tctgggtggt ctggagtgat ctcatcttcc 178320 aggaaagctg ttacacagac gttagtttct gaaaatgata tgacatgcag ctcactgtaa 178380 tacaatctat taattcaaca gataaagttt tatgttctaa tctcccagaa tagtacttaa 178440 acagtttagt gcacatgaat cacccaggaa tcctgttaaa taaagcagat tctgattgag 178500 tagcttggtg tggggcctag gattctgcat ttctaatgag ctcccaggtg ttgctgaatc 178560 tgctggtcca aggctggtat tgtcagtgac aaggctgcag gttcttagcc ctggttgttc 178620 attacaaccc cctgggtgga tttttacaaa taccaatgcc cttagagatt tgctttaatt 178680 ggtctgggct tgggctccag cattcatatt ttgaaaaact ttccaagtga gttttatgtt 178740 ctaccagcac tgaagaccac ttccctgcac aaacacaact gatgctgcct gtcattgtgt 178800 gtaactgaat ccactgatgt gagttggtgc atatcagtac cttttataaa tgcaaggaag 178860 gctggaggct ggggaaattg tcataagaca gcacccagtg cagggactag tgtacagcag 178920 tgtgtttgct gaataagtga gtgaggcaac gagtcatttt cagacactgt agaggatggc 178980 tagtgactgg atcccagtgc tgttgcctgg agctctagca actgtatttg gtatctctaa 179040 acatgctggc tatgggatag cagagttaat agaatgagac tggggccttc tacttccaga 179100 taaaaatttg gaaaggtatt agaaggaagg tactggggaa ataagttttg atctatgata 179160 gataagataa ttgaaaacca aaccaaagaa attaaattca gagtggagag gtgtattagt 179220 ccattctcac actgttatga agaaatgcct gagactgggt aatttataaa gaaaagaggt 179280 ttaattgact cacagtttca catggctggg gaggcctcag gaaacataga atcatggcag 179340 aaaacaaagc aaacacatcc ttcttcacat ggcgacagga gagacaagtg ccaagcaaaa 179400 gcggggaaaa gccccttata aaaccatcag ttatcatgag gactcactca ctatcacgag 179460 aatagcatgg gggtaactgc ccccatgatt caattacctc ccacctggct cctcccacaa 179520 catgtgggga ttatgggaac tacaagatga gatgttggtg aggacacagc caagccatat 179580 caagaggcat aaatcgaagg tagccttcca gggactgagg tcagatttgt cccaagttag 179640 acactttggg cacatatttt caacagacat tccacaaaat atgcaagtat ttattttttg 179700 atagtatgtt taaatacaaa tagaaatcaa gccttaaaaa tgactcgctg atgaaactac 179760 atttctcctg ctcgggactg catttcagat actgtccatt tgcatctggg tccatgatgt 179820 gctgttgaaa taacatgaac tcagcttgta ggtgaaggtg gggagggaaa catgcatttt 179880 tccatctgaa cagaaagtgt gttctggctt ttttctgaga tattattttt attgaatttt 179940 aagacccaca caggaagtgg ctttcacttg gtttcatctt cctgatcagt gcatgttggg 180000 gacaaaggag agaggaggga gttaacctgg ataagtctgc tgcttcttcg ggagagtggg 180060 gcatcccacc aacctgctgc ccatgttgct ttgtggggat acatgaagca gcttctagaa 180120 aggcttctct aggagcttgg tgaggctgtg caatgccttt tttgcaaaac gcttgctgtt 180180 cactaatgga gcagatgaaa taataaagcc aaccaaggaa gcaacttaat ggggaactaa 180240 ccagccacag tggcttttgg aactcttgtg ccttgctgca catcactttg aagtagtctg 180300 tggagtccat gcttctgatc cttggaacat ttggttcatt tttatgtcat tgttgtctag 180360 cgctaaccgc aactggtccc atagacctga agtagcccag gtgcaggggc aaagcagtgg 180420 ccaggtgtga gtgctgaggg cctaaatatt tcaagtacaa aacgcccagg aaaacaacca 180480 ccgggggctt taccatactt ataaaaagga atccttccct ctgaaagcct ccagcctgac 180540 tgtaggcaga agcagaagca gccattgccc atgcaaggtg aggaagaaca ggtgttggtg 180600 aacagagtgg gctcaggtca tcatttgtgt ggcaaaattc tatcagggat gaaagtatca 180660 gcaatgggac cacctggaac ccaagctctg ccactttctt gctatgtgat cctgggtaag 180720 ttatttagcc cttctgttcc gcggttttct cctctggaaa atgatgagga tgatactact 180780 ctgctcatag ggttgtttta agggttaaat gaggtactgc atagaaaaca ctcatctcag 180840 ggctgggcat gcacagtgca tgggtgtagc tatcatcatc ctcctcatat ttagaatgct 180900 tttctgtggc cacccatcat cagtatgtgc ctatcttcat cagcagtgaa gaggacagaa 180960 gcttctttct cccttcctgg catgctggag atgtggttgg tctcctcagg ttaccattaa 181020 attgttggca gtccccactg agagtaggga tgcagccaac tccacaggca cctgaggagc 181080 tggccctcta gcaggtgtca gccaggagag acatttacca aactgaagtt ggggaaaagc 181140 ctgagctgat tccacactct aagtcacctt agggcccaaa gaacaggtgg catgagatac 181200 tcagggaatg ctatggcagc gtgcctaacc atggttctgc aatcttcaca cccgaggtca 181260 tggcagcgga caatttctgt cttctggata agatgggggt gtatctgtct gtgagcattc 181320 attcactgat tcattcaaag tggatggatt gggcattgcc atggaccaga cccggcacag 181380 atggggtgcc cagggtggaa cggtgagcag tagtgccagc tgtgtctgtg ctcatgggcc 181440 tatggtcttg gggaagacct caagtaatca tgtaaataat gacctgctta caattgtgag 181500 acctgctgga aatgaacaac aggagtgggg gctgtacggg gaatttcagg ggacctggcc 181560 tgtcagaggt cagggaattt atgccctgga aagtgacaag ttgtccttta gattggttaa 181620 agaaaaatga aagtgcggag aggacattcc aggcaagggg aacaggtgca gtgggcactc 181680 acagaaggcc aaggggacag ccctgttcca caacagcctg ctcagagtcc agtttgctcc 181740 ttgctcctga ttggagattt ttcacatact gtctcccagc agaggattct gtccacaggt 181800 attgacaggg cctggctggt ctcttcttgt cattcaagtt gtagttcagg aaggatgcac 181860 ccagaaggct gcttttgact actcactctg aatttgccac ctccccatgc ccagcctgcc 181920 tctgtgtttt ctttgaaatt ctgccgttcc tttattcctt tgcttgctat ttataaagaa 181980 aagaggttta attggctccc agttctgcat gctgtaaaag cctggcacca acatgtgctc 182040 agcttctggt gagggtctca ggaagcttgc aatcatggca gaaggtgaag caggagcacg 182100 cacaccacac ggggaaagca ggaacaagag ggagagaaga ggaggttcca gactcttaaa 182160 caaccagatc tcctgtgaac gaactgagtg agaactcact tatcaccaag gggatgggag 182220 gtccacctcc aggacctggt cacctcccac cagaccccac ctccaacact gggaatcaca 182280 tttccacatg agatttggag gggacaaaca tccaagccct atcacctgtg taccatttgt 182340 tgcttctcct ctgaacaaaa gtcctcaaaa taggttcttc gtcacatcca ctgttgtccc 182400 ttattttcag gacactgtct gacaatctga caaggaagta gtgggcactc cacgtctgtg 182460 gagcaatgga cagtggctcc cagtctggcc aaatttccct aacatgaaag catggaacac 182520 ttcctctcac aggtcaaacg cgtggaatga atttgcaatg caattctcgg cacagctgac 182580 tttccttgtt gcttctgctg gttttgatca ctttccctgg ggtgctgtgc catcaggagc 182640 aggggcctcc tctttcctct cctgtcggtc ctctccaagt gatctgcaac ttcatcccgg 182700 ggggaaacag ggcagggaac ttcctcctca atttctgata ttgcaaggta gcaaactcac 182760 acaggccttg ataacaataa atgaagagtc aggtctttac aaatatgatg agaaaataca 182820 atggaagtcc cagtggggag tccccactta ctccttccat gccaatacag atctccctac 182880 agactttacc actggttcta tatatatgcg atgccagtgg gaaggtattt ctcagccgtt 182940 agaataatcc atttccttta tcccggacta tggataagag gacatttgca ggagagggga 183000 gacacttagg aagaaaagac tggctttgtg aatagaaata cattatttgt gcatatgttg 183060 tagctcgact agactttgag cagactgata tctgaaaaca tatttataag cctgttataa 183120 actcataatt ctaaaatatt gaattttatt tattttgcat ctataaactg agttttgaat 183180 ttgtgcagta atttgcatta ttcagaactc ttgattgcaa gtgacaaaca gaaatcaaaa 183240 aaaagtctta ttggctcaca gaactgaaaa ctccaggagt aactgccttc aggcccagaa 183300 gcatcaaggt gtccagaaac tctgacagga gcacctctca ctcttgctgt cagtcttact 183360 gctcttggag tactctggtt tagattggct ccttggcata cctagcatgg cacgttgcac 183420 acaaccccag tgacagtagc tcagtagcca gggggaaaga gtcttctttc tccaaaatcc 183480 ctgagaaggg tcatgtcaca tgcctatctg tgaacgagtc accatgtcta ggggcacaga 183540 ggtgatgacc ttggtctcat gcccatgagg gatggctcct caaaggaaaa cccaagtgct 183600 cttattctaa gagggagaat tggatgccca gagacaaagt ctatagatgt acgtggtcca 183660 gtgttgaagc ggtgggagga gagtgccggc aacacaggca attccacgtt gtgtgcgact 183720 ggcctgtgca tatggaggtg ttcagtgacc tggccctgga cactcctgct aacaggacac 183780 acacatactc tcttacacac atacatgtcc acacacacca cacacacaca catatacacc 183840 ccccccacac acacactttg acatacactc acatgcttat attcccccca caccatgcac 183900 agacatacac tcacatgcac atatgtcata cacacaccac acacactgac atacatacac 183960 ttaacatgca tacatgcaca caccacatga catacactca cacatacaca ccacacacat 184020 acatactaca catactggca tacacacagg tgcgcacaca cacacactca catgtgcaca 184080 cacacacaca tcattgacaa ctatgaaaag cccctgcata cctcagagcc cctcaagctg 184140 ggcttctgat gacacctcag gcactctccc ctttttattt tgtttcccat ttacttccta 184200 ccttaccctg ttcaggctgc cgtaataaag tttgatggac tgcgtcgctg aaactacaac 184260 agttcatttc tcatggctct ggaggctgga agtctgagat caagatgccc gcagggtgct 184320 ggtgagggcc ctcttcctgg tggcagaagc cgacttctcc ttctttcttt gcctggcagg 184380 gagcagggaa ggaagtgagt ggtcttgtgg ctctctgagg gcactgattc cattctgccc 184440 cacctcccat agcatcatgt tggggaacag ggttccagca tattaattta ggggacacaa 184500 acatccagcc cctaacactt ccattctcat taattgcctt caaagagagc taagctaatc 184560 ctaatggtaa ctttggcata aagcaaaact ttgagaagat gacatctgat atctgctgtt 184620 caatgcatgc ttgttgggag aagagtgtta agatttggac tttgcgtcac ttatggccaa 184680 aataggacgc tcctgtatgt ctgcacttga atttaaatat gccagtctca atataaagca 184740 cggaactcat gctgtttaag caagagcaca tattaaggct ggcatgtctg tcaagataat 184800 aattttgata gaggattaaa aaaaggaaaa aaatgtagag aactgaaggt aaaagatagc 184860 caggattaga cctttcaata ttaacagtga actttcttta gatatttctt acataatcat 184920 caatgcttat aaattctagt gcttctgtct tttcacagtg ttgtgttttt gtttgtttgt 184980 ttgtttgttt taacaacgta atgtgcttat tcctcaggct tcaggtaacc tctgtaatta 185040 cacacccagt gctgatgccc acgggctgcc acaaggctgg gcatgttact ttatgctcta 185100 accctatgtg ttcaataagt actttgaaaa aaataatatc ttgctaggca tattttaaat 185160 cataaaaatc tcaattttag ggttttcttc cctcaaatgt taatttacta tattatttac 185220 acttatttgc caaacaggga acttttgctc aaagaaacag gtgcagtttt agaagctgaa 185280 attaaacacc tctctattct catattgcct tttttccctt tggacacgcc ccaaagcaga 185340 catcctgctt acaaaagaga gcttaatggc ctccctcctg ctctccctgc ctgaagtctt 185400 tctagaattt ggaaatatgt ccattttgtt agggcaatct gttagtgtta atgattttat 185460 caatctaaac tccactaaaa gaagcaaatc aacacaatgc taataaattc tgtttgtttt 185520 ctaatcccaa gaagacacaa taaattaaca tacattttta attttaatta taaaaccttt 185580 caaataggga tgttgtctct cttatcctca ctgtcattct tgtgcctggt acagagcaga 185640 tattttgtga gggttatttt tgttgtcgaa taattgtatt ttaaatacac agaaaaggac 185700 agagagtcac aaaaacaaaa agcacgaaag aaaacaaaaa ccaggtactt aagcccaaca 185760 tagagtcaga tgtttatgct ttgccacatt tcattcattc ctttttttat gaatacgagt 185820 gttagataga attgaggtcc cactcacatt ttctatacac atcttgaaac ctctgcaacg 185880 tatttgtgaa tctgtaaacc atagaaacta acacagtgta tttttcaaat gcatataaat 185940 gatatcgtgc atgctaagat ttttcttaga tttcctataa atcatttcaa tcaaactctc 186000 cctacttttc tgtggaaact atgtaacaaa atgctctatt tccggaagcc tccaggccaa 186060 gggtgagtga gcctggggtg ttcaaatgta atcagagtcc aaaacaggcc cttgcttggg 186120 ctcaaactaa actgagttaa gaaattagcc tggaagggag agaaggtgat gtcagatctt 186180 aataggataa cattgccatg agttctcctt gcaatagagg aggctgcttt tcttcagcag 186240 ttattgagat gtatgtttct tttttcacta aatttctgtt attgtcggtt gattttgacc 186300 acaggttgtt gtcttattgt cttgactgtc aaggacatat aatggcagag ggattcttag 186360 gtcagcagac atgctctcag cttaggcaag cctcaggggc tgtatgtgtt tcagaatttc 186420 tcacatttta gatagctatc taaaagtaaa tgttaccata ctctgcatgt tttctacacc 186480 ctcacggtgg aatgtggggc agtaatgctt caagatttct tcagcagaac tgtggaattt 186540 ttattctgtg tgtaatgaac aaggctcaaa tagaacctca cgtccatttg ggccatgttt 186600 tggcagcagg tgaatcatga aaatactttt tcatttttga ggtatttttg gattgtggga 186660 ttgcagataa gggattgtag atgggtgtta ttgttgttgt tacaatataa atttctataa 186720 cttctggcca gttgttagaa ttatcccttg tttttcaatg ttgactccta tccctcccta 186780 cctctctccc tcctcctttg atttcttctt tcctgctttc cttccttcct ttctttctct 186840 tgtcatttct ttaggatttg aagagagggc acagtatacg atctttaagg actcagattt 186900 tcaagttaag catatctgtg gccaaattat ctttctgctg ctcattaact gtgtggccat 186960 ttttctatgt aacttcagga gtttcagttt cctgagataa tcatatctac ctcctgtggt 187020 tttgggaaga tgcagtaagg tgatggatgt caaaacattt aacacagtct ttagcatata 187080 actagcactt gatagatgac cactgctagt attgctgttg tcgttaccat atcacacagc 187140 atgcaccatt tgctattctc ttttaagcaa tgaatttatt cacattcaat ttcttgaaca 187200 tttttgaaat gcatctggtc ttcgcttaca tgtatgttat ttggcaacct gtctgaaaat 187260 attattaatt atggtttcta tcgttggctt tagctttaaa tgttgcttga aggcccctgg 187320 cacacagcca tgcttgacca tgtgaggaac atgatgctgc ccccatcagg tacagcctaa 187380 tggggtggat ggatggatcg atcgatagat acatagatag ataatagata gacagatagg 187440 cagatagacg atagataggc atatacatag atagatagat aattggtaga tatgcagaag 187500 aaaattagat ggtagaaagg cagatagatg aaagatagat acatagataa atagataggc 187560 atatacatag atggacagat aactgataga acacagatga tagatagata gataatagat 187620 aaatagtaga tagatggata gtagatagat aataaacaga aaacagaata gatatgagag 187680 agatgataga taactagagt gatagagaga tgagagagat gatagataga tagatagata 187740 gatagataga tagatagata ctcatctgat caccaaacag gtgtgaacag aggatgtttt 187800 aaagtgtggg attctgcatt tgctgtgaac aggagtacac cagacaatcc ttctatagga 187860 ggaagggaag aatgcatggg gccaaggttt tattttgcta agaaatcata gccttcccag 187920 agtttaattg cctccatttt tatcaaatag ttagaaacac gactattttt tttgaccctt 187980 ggaggcacat tggtgacatc tgtgggggca gcgttactga tggttgtccg tctgtatgtt 188040 gctgagccct gcaatcctgg tatcccaaga tgcctcccct cttccaaaga agcacttaag 188100 agctcaagtt gattaccgca ggggcttgaa gacgaagcct catttgcccg attatcagaa 188160 cagatgaggt gtgcacacag cctttgcaac tttccattca tctcaggaac taaaatgagt 188220 aatattttta agactaatgt cttaaattta tgattttatt tgattcttta ttcagcaatt 188280 tgaatattat ggttgattac aagtacataa taagagcctt tctgtgattg gcattttcat 188340 ttttctaggt aaataaagta cctcttgatc tgtttttatt tttcttccta cccccactcc 188400 ccccatcaat tttctttcac ttgtgtttct ctacacatac tgtgggcatc ccaaggggac 188460 cgtagtcttc ttgttcatgt ttcagacttg taagtcgtat gcaaatgcag ccatatttta 188520 cagattggca attttgctat aattaagctt catgaatatg aagattcttg tagaattccc 188580 aggacgcccc atggtgagga tttgcaatga aatttcttct cagctcactg tgacctatta 188640 gagtgtcagt ttggctcagt ttcaacatgg tgtttactct tatgaagtgc aaaccactta 188700 ttagctaatt tttaagccat gacagaagca gcctgagagg cacatttgtc cagagggctt 188760 gacaaaaagc tagaaggtca gtgtcttcac agacccactg aggttcagaa attaaatgat 188820 aattttgtaa accaggcagg aagtgacatt tgtgcaattg cctttgatat gttttctttg 188880 gctgtgtttg gtttctttgt ctctgcagaa tctcagaatg agccagcctc taactaaaat 188940 ggcgctgctt catcttaaaa tctctttgtg acagcttatg acaggagatc ccttggaacc 189000 ctggttctct gtgggacctt tcctggactc ctgtgtctgc aatacaaatg ttaattctca 189060 gctctattaa tacctcaata tcacttaaaa gatatccaag ggaaacttta cctggccaat 189120 ttctttccac aaagtagcat ttctgaattg gagattgctg gttggctcat tcttatttta 189180 tttacttttg taaacaggtt atcatttata attcaaaact caaaaagcat acagaaaaaa 189240 ttctagtctc actccagtcc cttactctcc attccctggt atgcctcccc caccctcagg 189300 tactaatagt tattcatcgg tatccaacct tccagaaatt ctcttgtata tacacaaaac 189360 aaatagaaat gtatcacttt gtaccaccag tactttagaa atcatttcag catgggtact 189420 cctgcggggt actccctgat cagattgccg cgttgtggaa gatttctttc tgcctgtcaa 189480 ttttatttcc agaaaatagt ggtcacattg ctttagggta agtcaccaaa gggtgtagct 189540 gcgcctgtgt ctgtgcagcc ctctggtatc ctgttctcag ctgaaaataa agccctggaa 189600 ttggtccatt tcactttttc tttttcttgc agtttgaaag gcacttgaac tagcccacta 189660 atgttgcttt ttactccttt tacattttaa aaggagtcgt accctggttt atttgctttt 189720 attgcctgtg aaaatggcct gagtaattag accaacagag aattgcatct taagggctaa 189780 ttattgatat attccttgtg tcagctcaaa agtaacctct ggggatagaa gattaggcag 189840 agtatgcctg cccatgaata tacactgttc atgcctctct aggcttcaac acacacaagg 189900 tcatgtaagg caaccttacc taccccatta gggtccagaa agatatccac ctaggagaga 189960 gtgtaaatat cacacccatc aactcactct tatgcccagt ggctcatcct ttcaaacatg 190020 caaaactttc tataatgggg aatctgaaat actttaacaa gtttaaaaat ctttattgag 190080 cacagatttt gatttttaaa aaatattttt gatagacata ctatggttca agtcccatac 190140 ttgcattaaa gggttaaggt ggaacaatgc ttcatgcaca gttagcattt catatttttt 190200 gtccagtgaa gaaaagaaaa cattctcaac tttgatctcc tttagtttaa aatgagataa 190260 gataagatac actccagcat catgctctta cttaaactga gctgattctc ttgatttcta 190320 tttcttgctt tcctcgccat tggcctgaaa tgagtaggca tgacaatttt tgtccatatg 190380 ttgtatgtaa ttaaactcca gcctttacat tgccaccatc aaagacagcg aggaagagac 190440 attttattat tgcaattcac tgtcttaagg tggaagcttc tgcaacggtg acacagaagc 190500 gtgatggaga aggcacaaaa atgatccatc ttgctctttt aagagaggag aacataccgg 190560 acttgtgcag acagaacttt tttttttttt tctattgaag catcttctag tgcatttaag 190620 cttttttctt gtcaacttga ggatggagtg aagaaataac acacacagct tgtttgacag 190680 tgtggctatt aatgaagcaa gcaacaacag ctttcactca tgcacaacag ggcttggctg 190740 tgtggtttgc aaaaagcgat gaacattttc acattaggat tttgaagggg ctggtgagga 190800 aactaaagat catcagcatt tgcgtgtgaa aataaaatgg aaacgttaag aaaggttgaa 190860 tgtagccttc aaaagggggt agaaagaaca aaatgaaata agagttgctc tggtttgaat 190920 gtatgtgtcc ccccaaaatt catatggtgg aacctaaaac ccaatgtgat aggactgagc 190980 agtggggcca ctaaggaaat gattacatca tgagcactct gcttccatgg atgagatgag 191040 tgctttattt ttgttttgtt ttgagacagt gtctcactct gtcacccaag ctggagtgca 191100 gtggtgcaat catggctcac tgcaacctcc acctcctggg ctaagcaatc ctccagcctc 191160 agcctcccag gtagctgtga ctgcaggtgt gcaccaccac acctggctaa tttttgtatt 191220 tttcgtagag atgggatctt gctatgctgc cacgctggcc tggagctcct ggactcaagc 191280 gatcccctca ccttggcctc ccaaagtgct aggattatag gcatgaccta ccatgccagg 191340 tggattagtg gtcttaaaaa agaggttgaa tagtggctca tgcctgtaat catagcactt 191400 tggaaagtca aagcaggagg atcacttgca tccaggagtt catgaccagt attggcaaca 191460 tggcaaaatc ctgtctctac aaaaattaaa aaaaaagaaa aaaattagcc agacatggtg 191520 gtgcacacct gtagtcctag ccacttggga ggctgaggtg gtaggatggc ttgatcccag 191580 gaggtcaagg ctgtaatgag ccgtgattgt gccactgtgc tccagcctgg gtgacagagt 191640 gagaccctgt ctcaaaaaaa aaaaaaagag agacagattg aagggagcac aatagcacct 191700 tttgcccttc tcccatgtaa aggtgcagct atagggtgac attttagaag cagagaggaa 191760 gccttgccta gacaccaaat ctgtctgtgc cttgatgttg gacttcccag cctttagaac 191820 tgagagaaat aattttatgt tatttctaaa tgacctggtc tcttgtgttt tgttatagca 191880 gcacatgtgg actaagacaa gcatgatatt ttaggttcct taagcagggt agagaagaga 191940 gtcagaatcc taatatgtct agttgctgtc aagatgggtg catgagtgtg gcacgctgtg 192000 gactgtgcac tgcaagaaag caggctccat tttctctctc cttctctggc tgcttcggaa 192060 tctccctaag ctagctagtg attacctagt acaaatacgc atttccagac gtatctccct 192120 gtctagactg agagtatctc cacagctgag ggggtatcct taacccctgg tggaaaatct 192180 ggtacttagt aagtgtggca ggcagagtaa tggcccctaa agatgtgcgt gtcctaattt 192240 ctggaaggtg aatatttcac cttacatggc aaaaaggatt ttgcagatgt gattaagaat 192300 ctggagatgt gattaccatg aatcacctgg atgggcccgg tgttgttcaa gggtcattat 192360 aagtgaaagt cagagtcagg agagtcaagt tcagcatgat gagatgtgag gaaaactccg 192420 ccaggcactg ctgactttga ggatggagga agcagccatg aaccaagaaa cagggatggc 192480 ctctaagagc tggaaaacac aaaacacact ttctcctcga gccttcagaa ggagcacagt 192540 cctgccaaca ccttgatttt agtccagtga gatccattta ggattttgat ctctaaagca 192600 tgaggtaaca aatttgtgtt attttgtgcc accaggtttg cagtgatttg ttaccgcagc 192660 tgtaaaaatt tagtgcagtg aacaatcaaa atcgaacagc ctcttgcttc acatgtgcca 192720 tgtgctgaca tcaaagaggt gctgagaaag tactgctatt gattttgtac tagcaccaga 192780 aagcagagag catgcttcta ggactcaacc tagagctcca tttctatgct cttgataaac 192840 aacttccatc tgcatatttg ggtccatttc cctgatagcc aatatgattt ttaaaggaaa 192900 acaaaaatat ttttaccaga cagtaatatc gtattggtga ttgggttaaa aagctaacag 192960 tttttcatgt atgtaatggg tgtgaggttt ttcttttttt cttttttctt tttctttttg 193020 agatggaatc tcaatctgtc acccaggctg gagtgcaata gtgtggtctc ggctcactgc 193080 aacctccgcc tcctgggttc aagcaattct cctcccttag cctcccgagt agctgggatt 193140 acaggtgccc gccacaatgc ctggctagtt tttatagttt tagtagagat ggggtttcac 193200 catgttgccc aggctggtct tgaactcctg acctcatgat ctgcctgcct tggcctccca 193260 aagtgctggg attacaggcg tgagccactg cgcctggcca ggtatgagtt ttaatccaca 193320 aagacggcat ggttagaatt gaagttgtat ttttgtatag ttcaacttaa tttgtaacat 193380 atactgcatg atgccaggtg gtagaatctt aatttcattt aattcacgat gatcacagtc 193440 aacgcggggt cttctccact ctgtgtctgg gtgctttcct ctgtgtttag gagtctaacc 193500 tggggctaaa ggatctcagc agaccaagta gagagggtgt ggccttcttt ccatcactga 193560 taccaattca cggccggcat ctgcagctac caagtttcca tcattgagtc agattgcctc 193620 tggcctcttg tgtccttaac tattaatata aagcctctcc acaaaaggct ctttcaacaa 193680 catctatggc cttgtgagac accctgaaaa tgcctggctg tggaccaccc tctccagagg 193740 tggaggaact ctcttaggct gttgtaggac catccacctg ggcacatcaa agcagccatc 193800 ttttttctac tgctccaaga ccgtgtcgtt aacaggaacc catgtggaaa tgttggactg 193860 tgttggagtt tcctgagacc accccttggg ttgatgattt gctggagaga ctcacagaac 193920 tctgaaaagc tattgttgtt aaggttatag tttatgaaac agtgaaagga tacagattaa 193980 aatcagcaaa ggaaaaagtg cataggaagg agtccaggaa agaccaggca caggcttcca 194040 gttgtctttc ccggagacct atagggacag ggcttaactc ttccagtaag aagttgtgac 194100 aacacataca gagtatcatc aaccagggag ctcatacaag ccttggtgtc cagggttttc 194160 attaggggtt agtcacatag agtgctcaga tgacttacct taacacttga gtctccaacc 194220 cctcctccag aggttcaact gacacagcgt ggcccagggt cccagaagaa taaaaacaga 194280 cactcgtcat aatccaattg ttggcataaa caatcttgcc tggccccaag cctcaggtct 194340 gtaatgacac ttttatcagg ctggaaattg caacagctta gaggttacct cctaggagtc 194400 agtcaagggc aagatctttc tttagaatgt gtgggatttg gaccccctaa gcctgtggga 194460 ttaacccttt actgcacaca ggcctagatt ccctgggctc tcagctaagc ccaaagccat 194520 gtgtggtttc cactgtgtct cctcccattg gatgtgcctc ctgtggatag gtccttgact 194580 cagggcttct ctgctgttag ccatgggctc gttattcagt ctgggtggaa aaaaatggtt 194640 ctggctgatc acatagcttt tggcatctgt tgttcatgtc atcaactaaa tgacatgaca 194700 cagagattag gcttttgaag ctcaaagcag gattcttata gctagaagtt gttttttttt 194760 ttttttgttg ttgttgttgt tttcaaattt ccaaccttaa ttttaacttc aggggcacat 194820 gtgcaggatg tgcaggtttg ttacataggt aaacaggtac cacggtggtt tgccgcacag 194880 atcattccgt gacccaggta ttaagcccca catccatcag ctattcttcc tgatcctctc 194940 cttccctcca cccccaccct tcaacaggcc ccagtgtgtg ttgttcccct ccatgtgtcc 195000 atgtgttctc accagctaaa agtaacttga ctttctcact cctttataat cttttacctt 195060 ttcccctgag aaaagaatgc caccaactaa atggggaagt atggccctag agaacagtgc 195120 tgaggtcagc aggtggggcc agcagagaaa aaggtggggg ggctgacctc ttttgtgcct 195180 gtcccttatt aaggaggaaa tcctttccca gaagtcacca acagatttta aaaaatgtct 195240 ttatctcatt gaagttgggt cccacttaga ctaattcctg gcagaagaaa ctgattttgg 195300 tgtatttgac ttaaagcaaa cataatgtat tccctaaaac tgagtatata tccatcagaa 195360 caaaaccaag atatttcttg agcaatcagt caacagtgtt ggctataata tgcatgtaag 195420 atataagact ctgcagcctt gtaaagctgc ggtgaaactg agtttccaac aggtcagaga 195480 gtgacgaaat tgcagtagct ctactccagg gactccacag cactctttag gttgggaaaa 195540 gcaagtgagt tgcttttaca ggtgtaaatc agagggatgg aaattattga tgagataatc 195600 gagatgggat atgagcaggt attcagaata tatacggttt gcaaatgaga atgaagactt 195660 cccaatcctt ggagcagttc ataaaggtat gtcaaagcct gcaggagcct aaggaagaat 195720 gtgctaactt ttgaaccatg tagatggctc ataagaaata taaatattga atacactttt 195780 gctgctatta gtggctgcct tcatagttgt gctcagtaat ttgcctgaag accctcaagc 195840 cttgcggtgt taaacattgt gattcaaaac ccaaatctag ccaaggccgt ccatgtgtta 195900 gatgcttctc caccccagga gacagggcct ggagttggtc tgtgtgcttg gagctcatga 195960 ggcaatgacc tgagctgcaa atcttcagct gtgcacccac aaagctgccc cagaatccta 196020 gccatagtgt ttcaggccag acctcaactt ttcctcggat catgggttat actccagatt 196080 ttgaactgga cagctggaca acctttagga accctcccct agaactggga aaactcctaa 196140 accaagctcc tgcctgaccc actctccagg ctccaccttt cccctcttct ttatttgttt 196200 atgatggagt cttgctctgt cgcccaggct tgagtgcagt ggtgcgatct cagctctctg 196260 caacctccgc ctcccaggtt caaccaattc ttctgcctca gcctcctgag tagctgggac 196320 taaaggcgca caccaccacg cctggctaat tttttgtatt ttagtagaga tggggtttca 196380 tcatattggc caggctggtc ttgaactact gacctcatga tccgcccgcc ttggcctccc 196440 aaagtgctgg gattacaggc gtgagccaca gtgcccagcc tccccacttc tttattaatg 196500 aagacagatg tcccagctca agaaaagaga gtggaaaaac tcctccttct tctgcctttc 196560 tgttctatcc gggctctgaa agaactggac gacgccagcc cacgtggctg aagacaatct 196620 tctttactca gttcactgat tcaaatgtta atctcttctg aaaacacttt cacagacaca 196680 cccagaaata atgtttaacc agttatctgg gcatctctta acccagtcaa gttgacacat 196740 aaaattaacc catcacaatg tcattgatga aaattgccta aatacctcca cccttgtgaa 196800 attgataact accttgtcta accacttagt taatgataag tggaaatgtt gcctctacat 196860 catgcaaaat gtgacagata gggaataaat gcttagagat gcttggatga aataaagcct 196920 tgtccagatg aagaggtttt tgttttgggc atttgacctt gggaagcagt tcaattaaaa 196980 aaagaaaaaa aaagtccccg tcagtgattt tatagcacct ggtaaaattg caagtgattg 197040 ctcacttctc ccctgctcct tcacccctgc aataagcttt gttgtcggtc acagccttat 197100 gacctcctct gtgctgctca tctcacagag agtgtggagc accctggaag tgagactcaa 197160 ggccaccagc cttctgcaat ctccaggtct gtacctggag caaactctac tctgtctctc 197220 tctctctcca agtttccttg cagaaggcac tgctgacaga ataggtgaga caaaatatag 197280 tgaaaagagg agctggtgcc atccaatcca gagagacaac tacctggcct gcagtgccct 197340 gggcttgctg gcatagctgg gctcaactga acctttcctg cacaacatct ctattttgtg 197400 acctcactgt ggcacactca cctctcaaag cgcttctgag acctccccta atgtgaacta 197460 ccttggcatg tttttttcca cccctgcata ttattgtttg tgtgtcactg ttctcattgc 197520 cagggcattg cattgggatt tctttgtcag agcacataaa gaggcgtatc cagaataggt 197580 atccagccag cataaaacaa tgtggcataa tgtgttgcta aagtatatat attttaaatt 197640 cttctgtagt agttggtaat cagaaatagt ttacttgaga ccacgcatta tctaatgacg 197700 ttggcccatg gaggctgtgg tggtggtgtg gtcttgggag tggggctgtc ttggaggtgg 197760 acagaggtgg aggttccagg tgggatgtgt gcaatgcctc ctgctgctct ggagtgggcc 197820 agaggtggca gggacaaccc aacagggtgg gggctgaggc taaccttgag gaattggggt 197880 tgggaccaag acaatggtct tttaagttca agctagctga aaagtgctgg cttctgggtg 197940 atgcccagcc cagacacctt cttttgtaac cagatgtagt gcactggcct gatgactatt 198000 agcttaatgg gaggtcaata aagtgtgtga ggctaaatca cagtgatgca gaatttttct 198060 cagccacttt gccaacaaga gacctccatg gctggcgata tccccctgcc tgggccttgc 198120 tcagccccgg gcctgccatt ggaggcaccc ccacccgctg agcttgctgt cctatagctt 198180 gtacccatgt ttggcagttc ccgagctcct gtcccgtgtc caagaagaat gaggatacac 198240 tgacaattcc aagggtgagg atgggcagag aagaattgta ttgagtgatg gaacagctat 198300 cagtggagag gggatacagt gggtggtccc ccaacccctc agttgggttg tttatctccc 198360 agtgtggcta ggtctggagc tttttatgga ctcaaaatgg agagtgtgtg ctgattggtt 198420 tatgagtgtg caaaaaaggt taaaatgaag acaccactca aaggcacgac agtgtagaaa 198480 actaattagg aaaggatagg tatatgtaaa atagatgaag ggtggggatc aatcagagaa 198540 aagtgcacca aaatggaaag acaggttctc aatccagtct gtggatgtac ccaggactta 198600 tagctaggct ttaaactgtc ttcggcttga aggttgggtt tcaatgggga cccaccactg 198660 tctgcctagg gatttgtctg tctcctgcca ctatcaacag ctcagccacg gacgtcagct 198720 tgggacatct gcccaaacga gagatcaccc tagcaattcc taaaatcaga agtgtcagga 198780 cagttgggta aacaatgcta tagcttcaga aacttgctga gcagtgtgtg agtgtgtgtg 198840 tgtgtgtgtg tgtgtgtgtg tgtacaggga tatgtatgaa attagaggaa agtttttaat 198900 tactaattta tgtatttgtg caggttgttg aattatttta gtatcacccc agatatacat 198960 gcagcacagc agttattgaa tcttttcagt tactgagtct tttattttac ttttccaaat 199020 tttgcaagta tgtgaactac aactgctttc tttctctatt tatttgtttt cttgctactc 199080 ggtgcatgtg ctgttgcatg caccaagtta attcatttta tttccctaac aaatgtcagt 199140 atctctccct ccccctatgc agcacatcat tgcccactca gcgtcactgt ttggcacatt 199200 caatgtggaa gacacatggg tgaatcattc ccagcatctg gacatttaga gtcagctgga 199260 tgctgttggg tgtcttattt ttcatgcaga tgtgaggcat tatataaagc agccacattt 199320 gtattaatgt tgaaaggtcc tagggtttct gcattatgaa atgaaaaata gctattagct 199380 actattatct gatgaggttt gaaggtatgt agttctagaa ggaatatttt gaatggacat 199440 aatttctcaa ataatatata gtttttatcc taactacacc aaagattttg tcttataact 199500 gtgctagcac tattaaattt ttgtcctatc actagaaatt ttgctatttt agacaagaga 199560 acctgacttt ggactatgat ttatgtaatg gaatttcgag tggtccatta aacttattta 199620 ataaccataa aaactggcat aaaattagcc ataattcatc aaatcttaca ttatattctt 199680 agtctgggat tgatgtttaa tcagattttt tattgtttca taacatttaa tgggctattt 199740 ataattattt tctcaactat atctgatgga aaaatatatt acagaagagt ttttaatgtt 199800 ccagaaataa ggatataaat atacaaacag tgctcaccca cacaggaact aaggcaaaga 199860 ttgttgctgt tataatttca gagcaaatcg attggccttt gtaagctatg attagtgtag 199920 acatcctaat aacagcgtgt ggtgaatgct ggtcttctga actttaacaa ctcctccaat 199980 tcggccacca ataaagtgat gataatagga ctgaaaaact tgttctcaca gtgataaatt 200040 tgcatagccc catgcatatt tgtggcttga atttttcctc cttcaaaatc ccagagcaaa 200100 atttgaacaa ctttgtgtct ttatgatgtt ataaattctt ggcaagaaag tatagagtga 200160 tggcagagag caaagcgaaa ctttagaaga gaatattggc agaaaccctt ggagactggt 200220 cccgagctgt gtgtgcaagt ggatgcattc atgcatgcag ggcatggagg ctctcagctg 200280 tgatgggacc caagagatgg tccagggccc ctggagggcc tggaagagat tggaaacaag 200340 agtcgagagt gttccctggc agctgagcaa ggccagtcag cctcactgaa attcaactgc 200400 acaccagctt tctacttaat atgttaattt tgtgttccat tttctcctgc aatcctttct 200460 gccagccact cttcgctttt acatgcttca tgttggaagt cattatttct gtcatctcta 200520 aatatttcat ccaaggaaga aaagctagga tatgtctaga gaacagaaac taagtttgta 200580 ggaagtttgg tgggcaacac gatggactcc agatcagtca atgccacgtg agttctcttt 200640 gctaacaaga aatcagtgct catggtatca ggtgaacagc cccccttttt tttttttttt 200700 tttgacagag tctctcactc tgttgcccag gctggagtgc aatggcaagc tctcagctca 200760 ctgcaacctc cacctcctgg ggtcaagcct cctgcctcag cctcccaagt agttgagact 200820 acaggtgcat gccaccacac ccagctaatt tttgtatttt tagtaaagac agggtttcac 200880 catgttggcc aggatggtct cgatctcttg atctcatgat ccacctgcct tggcctccca 200940 aagtgctagg attgcagcca ggagccactt cttttagtga ttttcaggat taatttctag 201000 gccttatgtt ccaccctgtg tctttctttt caatcctagt ttcacagcct gctcccttca 201060 tcggctcaaa cttcatggtg gtactttatc tcctccaccg cctccaagaa cggtatcttt 201120 tcatttagtg cagttaattt tataggctaa aggctctaag gttctaatac ttgtattgtt 201180 tttcactctg cacccattgt attttataga ggaaatattt ttgatgtccc aagacagttt 201240 aaataattta ttgttttgga atattccctg gacacaacaa aatacttttt gctcaatttt 201300 tccatttttc taaattgaaa tgaatttaga agtgaatatg gtaaaataat tgtataataa 201360 ccacttgatt ttttagaccc atgacctaat atcatcaaaa cacatcacag tgttttgtga 201420 attacaggag tatttacctc agatagagaa ttggattgtg catttctaac ataaaacatg 201480 aagaggggca ccgtgtatgc ctgcctgatt gctatgagat ttaggaatcg tcctacctat 201540 tcttctcata ctacttatag ttataagtct ttactaaata gtggatgcct actaaaaaaa 201600 aaactgaatt aaagcatcac atgattccac aaatatggat cagttccaat tttcactatt 201660 ttaccctaat tcaattaaca gccttctaca gtccagctga atttcatctt tatgtatcat 201720 catctctaat aaaacatttt tactcttggt tcatgattta tactgctctt tatcggatac 201780 tttacattca gttattgcat ctctgtggtt tcggatgcct gtgtagcata ctcaatcatc 201840 aaaactgtaa gaaacagggc tgattgttat ttctatgctc aagaacattt tctttaattg 201900 ctgtggcttt caggacatca aacaaccacc acagaaggaa gggaaaggaa atattaggga 201960 gaaaggatgc aagaagagag tacgttaatt attctcaaaa gagcccatca tgctctttct 202020 aggctgtgct aggaaagtgt cctagattgg cagcccccgg tatgtgtatg cttctgtggc 202080 caaaacctga agctggaata aaatgaagtg tttttttctt gaatctttac ttgcaaaatt 202140 tggtagaagg gtatgagtgc ttggctttag taacttgaaa acaattttta aaatttggca 202200 gttgtatttt gaaactgttt taaaaagaag aatgactata tatctcctca gattttaggg 202260 atggaacgtt ttgactgtga gttgtccagg ttcttggtgc attgagcaaa gaactaaaca 202320 aaatccacaa aaaatgcaac aaggaatgaa gcaatgaacg aagtaacaaa agtccagctt 202380 tactgaagtg aaagtacact ctacagagtg ggagcaggct caagcaagca gctcaagagc 202440 cccgaatgca atgttcttta gggtttctat taagctaaaa gaatttggta acacccctag 202500 gtgccctttc gaggcctcca gttagtcaca ccctatgaaa gattggccca ccaccaatca 202560 gaggctgaag tgaagacttg gcccacagtg gaccagaggc tgaggtggaa actactgttt 202620 tgccatcaca ggagtgaggg catggcctgt gtgctaatct ttcctagaac tggccgaacc 202680 tgctgttttc ttgcttatgc cttaaccctt ggttacccta aaccctattc tcctgcctca 202740 ccattggtta gctatccatt ttctattttc actcactctg atgagggtcc caactacaga 202800 taaaccactt gactcaccaa acactgcttg ctgaagtgag aaatgtcata aagttatctg 202860 agtttggctt tgtactcttt tatttgaaag agcgtgttca tccattaacc catccattca 202920 gaaagcattt attaagcacc tgctgtgtgc tggctttgct cactctgcca agctgtgaaa 202980 tctgtttctc taggcggagt tctgaagtca cccacattct gaatctcagt cttggaccaa 203040 ctgaattaga atgtctgggc tggggcttgg gaagttggga gtttaacaag atctgccatg 203100 gtttttatgc atggtgagcc tgctggtctc aattgaacaa atgtggatgg aatgaagcat 203160 ggattagtct gttcaggctg ccgtaacaaa atccacagac tgggtaacaa aaacaacata 203220 aatgtatttt cacacattct ggaggctgga agtccaagac taagtgttgg caagtttggc 203280 ctctccttgg cttgcaggta gctgcatact cattgtgtgc tcacatggtg tttcctctgt 203340 gcacacatcc ctggtatctc tgtgtgtggc caaccttctt atgaggacac cagtcattgg 203400 attagggctc actttaacag cctcattcta acttgaagac tctgtctaca aatctgattc 203460 tactgggact gagggcttca atatatgaat tttgttggtg agacaccatt cagccaacag 203520 caaagcaaaa gagtccactc ttggccggca tcccaaatta gttgaacctc tgccatctca 203580 agccagagct ttgcagtcca ctctgaaatt ggtgggtgac ctgtggaggt agtttctccc 203640 ctgagagctt ctcagtgcac agttaaggct ctgaagtcct cctgagcagc tcgcgaaact 203700 gaatttaaac caaagttttc tacaataatt tcaccatgac cctctgatgt ttgcaaaatt 203760 tctgttctca aacaggttgc tcacttgtaa aatatgttgt ttctccaagc tagagaaaat 203820 aaaacaagaa gaagtcaggc cccttcctga aggccaccca aatgtgactt agagatgaga 203880 tatcaatctg tcttactcag ttcaagacag taggaaaaac attgtgtatt tacaggcagt 203940 agccatcaga cagatcttat tcctacatat ctgagctgca ctctggaatt ttatcatatt 204000 aatctctagt gtctcttcat ctacccaccc cgccactcat ccctctaata gaaaacagtt 204060 ttagttcact ccagagactg cagcaggtgc caggagcctg aaacacacag cagccccagc 204120 ctatgtatcc cagagccctg agtccaggct ctatgctctt atcaaagcaa atacagagcc 204180 catcactggg tctcctggga ggccctctgc cctggtgatt ctcattctca tcacacatca 204240 gaatcacagg aggctgtaat ctttgagagg ccaaggtgag ccaattgctt gaactcagga 204300 gttcaagacc agcctgggca acatggcaga acccccaact ctactaaaaa aataaaataa 204360 aaattagctg ggcatggtgg caagcacctg tggtcccagc tactttgggt ggctagggtg 204420 ggaggatggc ttgagcctgg gaggtgaagg ttgcagtgag ttgaaatcac accactgcac 204480 tcaagcctgg atgaaagagc aagaccttgt ctcaaaatca tttttaaaaa aatgaaaata 204540 gaattacagg agagcttgtg aagaggcaga tccctggact tcattcctca cctctggaac 204600 caaaaactcc tgtaactggg ggcagaaaaa tttctctttt tggaagctct ccaggtgatt 204660 ctagttctaa accatggctc tttccggtgt aatttctcag tactcctaat gggtgctttt 204720 aactatgacc tagatcagct gctccctctt gcttgtgctg gatacatact tatcgtgcct 204780 ctgttccagc catgtcaccc tgctgtgctc tccgcctcca gtgtttcttc attctttaga 204840 ctagcacctg cccctcttca ccagggaagc ctgcatcatg aggaacacca gtattgaagt 204900 cttcatctct gtgttccttc agggctgtgg agtccaacag ccagggccca gctgtgccag 204960 tacaagatgt atcaccctgg acaaatattt accctctctg agccttgatt ttcccatccc 205020 aatccacaac aggaatacat gaatataatc tttgtttttt tttttttttt tgagacagag 205080 tctctgtcac ccaggcagag tgcaatggcg caatctcagc tcactggaac ctctgcctcc 205140 cgggttcaaa caattctcct gcctcggtct accgagtagc tgggattaca ggcactggcc 205200 accatgccca gctaattttt gtatttttag tagagacggg gtttcaccat gttggccagg 205260 gtggtctcga actcctgacc tcgtgatcca cccgcctcgg cctccccgta gtgctgggat 205320 tacaggcatg atgagtgtaa actttgaaat acatattaac ttggctttta tcagtgtgta 205380 gtaaggctct ccatgtcaga gtaaataaat ccaccaaata ggagtcaaat aaattcttat 205440 ctgaaaatcc aagccttaag attaggatat tctagaactt ctcttctaga tattttcaat 205500 catgttgaat ctcttgtgtt acatatttaa gagaaggaga aaagaaagct tcttttgaaa 205560 gcctgtgacc aaaagaaaga actggaacca gcaaaagcaa attggtttgt tttcactcaa 205620 ataaccgtct gcttgactta aatgtgatct ggcaaatggg cattgctaca ggaaacaaaa 205680 ggcttctttt gagcttctag agaaagagaa agcatcctga atacttaatc aagatacctt 205740 ttcctacaat tagtggaaac cagctcatgt ctgttttctc tcgccccgtt tccttgtata 205800 acactcatct agctgcttcc gtgaggtaga tttaaacgtc caccacccag accacaccca 205860 tggggccacc aacattctag agcagcttgc tctgtgcatc ttatccacac tgccatgcgc 205920 tctgtttatc tcattagaaa aacccttgca tatttactaa aggcaagagg caaaataaac 205980 gctgagttac atatgtaaaa ttccatgcag catcgttctc ctatgtatta ctaggtttgg 206040 ttattttaca tgaagacagt ttctttttac acaaacagta gggctcttat gcagttgttc 206100 tctttcaaca tgaacacaat agactagata atgttgtctg tttatatttc tttccgaaag 206160 taggaataat ttcctaaatt gctttcacgt actgtgtaaa acaccgtaga agttctgagg 206220 cttatctgac atctcattgt cccctggtgt gtgtgtgcgt gtggtgtttt tgtgtgtgtg 206280 gggtgtgagt gtggcagaga ggaaagggga gctgtttgat tctgtagttc cttttctgcc 206340 ttcttccttt ctctgtaaac tttggatact tatccaaatt actaacggca gattgagccc 206400 tatgcagatg gcatgtgtct gtgacaacct ctgctctcca catctcttgg gcctgtttac 206460 ctgcgctccc agagcctccg ccagcatccc agaatctcca tccccatctc tcacttatac 206520 acacatcagt catcggttat ccattagcta aaccgccttc cttaatagct ttacactgtt 206580 tgctttctct ggaacatttt tagttaaaat ttcataatgc agttgcacac aaatgaagac 206640 acagatggct gcatcctccg tctcttcccc tcgtttacag gaagctgcgg atcagggagg 206700 ggtgttaggg ttacccacat ggtaagggca gagacaagag gggaccccag ttttccatgc 206760 tgcacatggt cattgctggg gactgaggtt tgcacatcac cctgccctgt tctccctccg 206820 ctggggagaa agtcagggat ggagcaagct gcagcatctt ctgaaaaaga aaaggtggcc 206880 ttgtctccag gtctcccctc aagtcccacc ttcccatagt tttctgccac ttctcttgat 206940 tttcctctct gccacttctc ttgattttcc tctctgcagc tgctttgagg tgggttttct 207000 ccagatgcac actttcccct gctttgcgtc cttattctgg tagaagcaca atctaaagct 207060 cattaaggga actaatcaat tctgtgcatg gcgctagctc agcagatcac cacacaggca 207120 gcactattag caagtcggtg cttaacacat ggcacttcca tgaatcgata tggagcccgt 207180 gtagaacaag gcatgggttt ttttctcctc ccattaagaa aaactgatgc caaaaataac 207240 ttctcagata ttttcaagta tgacttttat ggagggaaaa agcatttttg tttgcaaaat 207300 catgcttcaa tgcaggccag ttgtgaattg tgatggcttt tatttctcct ggggctgtaa 207360 ctttaagggt ttagaatttg gaaccacagc ctagctaatc atgacacaca cacacacaca 207420 cacatgcaca cacatacaca tacacaaagc atcacgaaga accatacaaa ttgtacatta 207480 ttttacacat ggaggctcac tctaaaatag ataccatttt aaatattaac taaaacttgt 207540 gctcattgta tgttcattct atatgtactg atttgttatt cacatttctt tcaaaatcgt 207600 tcaaatttct agcccacatc aattaaatat taatagtact ttctacaaac atgagcgcac 207660 aaaataaatt caaatctatt tttcccactg gtgttatcag tactgctcat actttgtcag 207720 tatctaagta tcacatgatc ttaaaactaa tgtcacatac taaaaagctt ctgaggcaaa 207780 ttgtagaaag aactctcaac atcattgttc tactggacaa catacataaa attattttac 207840 agtgatggga gagaaatagg ctcctcatcc taaaagctgc gaagacagta gcggtgccgt 207900 gttttggcgt tactcccctg tggatcccag cgacgggtgg atttctcctg tgctttatca 207960 tcagacacaa aatggaccaa aatggaccaa aatggacgag tgtgagggac acagaggctg 208020 ctgtaaaaaa aaaaaaaatg caggatattt atgggtctat gacgacccaa ataatgagca 208080 aacatgggaa tcccctgctg aaaagctgtc acagaactga agcctgcctg gaaatatctt 208140 gagaatgttg atatcatttt aataggatct aaaatgagaa ttctatcaat ataaaacagg 208200 gagaagggcc tccttctatt tttaaaaata cccaacattc atgtttttca tattttccta 208260 gcctataatt actcttaatc aaagcacaac aaatagtaaa cagtaaaaat gaaataaatg 208320 tggtgacagt ttgccaataa cgaggagaaa atgtcccatc tgtctagccg cgagtaaaat 208380 gggtgtaatt accgctcatt tttctcgtaa ttgctgagtt attagtttaa agcttacaca 208440 caactggtga acagtgagta ctacccattc cgtaattaca gccccagcct cgccgtgctt 208500 gaaatcaggg aatgcaagag cagaggaaac gatctgaatt aaccctgact gcttgcacag 208560 aattgtgact gtctatctta tatttaaatt ttataaactc tgagttcctt tgctatccaa 208620 atgttaaact ggaatgtttg caaatccagc ttgaattcta atttgctttt aagctatagt 208680 cttgcatctg cttctaatgg tgaatgcata aattcatttt tgatagaaat aatccatgca 208740 gaccaccacc ctttgcattg catttgttaa agttatgcat ggttcactga tatgcagggg 208800 tctgttagca gttatgttac catctcgtta ccagggaaat tccatttgaa agtttaggat 208860 tacacatggg tagtcaacac ctgacgtaca cagcagggca aatacagaaa aaagaatctc 208920 ccttgattgt ttctgtttat tacaaatcaa agattaagac aaatagagct gtggtttatt 208980 tcttcttcca gtatgttatt ttatctctga gattcaccta agaaagacta agttctatga 209040 tgttctcata gaactatagc tacttttgcc taaaatgctg atatcatttt aataggatct 209100 aaaatgagaa ttctatcaat ataaaatggg ggccgggcat ggtggctcat gcctgtaatc 209160 ccagcacttt gggaggtcga ggtgggtgga tcacctgagg tcaggagttc aagacctgcc 209220 tgaccaatat ggtgaaaccc catctctacg gggttttttg taaaactaca aaaattagcc 209280 aggcgtggtg gtgcgcacct gtagtcccag ctacttgaga ggctgagaca ggagaattgc 209340 ttgaacctgg gagacaaagg ttgcagtgag ccaacatcat gccattgcac tccagcctgg 209400 ctgacagagt gagactctgt ctccaaaaca gaaaaagaaa aaaatttata tatatatata 209460 tagatatata tttatatata tttatatatg tatatattta tatatattta tatatatatt 209520 tatatatgta tatatttata tatatttata tatgtatata tttatatata tgtatatatg 209580 tatatattta tatatattta tatatttata tatatttata tatttttata tatttatata 209640 tatttatata tatttgtata tatttatata tatatttata tttatatatt tatatatata 209700 tttatattta tatatattta tatatatatt tatatttata tatatttata tatatattta 209760 tatttatata tatttttata tatatttata tttatatata tttatatata tatttatatt 209820 tatatatatt tatatatata tatttatatt tatatatatt tatatatata tttatattta 209880 tatatatata tttatattta tatatattta tatatatatt tatatttata tatatttata 209940 tatatattta tatttatata tatttatata tatatttata tatttatata tatatatata 210000 tatatgaatg agaagggcct ccttctattt ttgaaaaata cccaaccttt atgtttttca 210060 tattttcaca ttctagcaaa ggtagatttt ctgggttacc tctctttggg gtcctgtctt 210120 tggtctatac agggaactgt aactcaccac agacagagat agtgctgaga tgacaaagct 210180 gggcttgatt ccgcttggat ccctggcttc tcagccattc ctgatgaacc ttttattagc 210240 tgcctgtctc tgatccggga acactgatga caggtgcgtt tattttgagg gagcatatcc 210300 tcaagctatg gagtggttgt tgaatgagat gttgtgaaaa aaaaaaaaaa aaagtcatga 210360 gacccccggc caaaatcctc agactagcgt ggcatttttt ttttcctagc aagttatgtc 210420 atttaattta tagatataga agtggagaca atgaaaatat agcatagtat gttcatttcc 210480 ttcctctgag cctgagtgat gccaaggcat atttttctat gttagaggga ctaccctgga 210540 aaaaggaatg gttatagtaa aatttggtat ggaagattca ctgatacgaa tctcacattt 210600 tcggaaagag aggagatgag gaaaggactt ggtgatgatc aaatataacc taagaatcaa 210660 agttatttcc attcctggct gcagaagcag tgaaccaccc ccttccttct tccctctctt 210720 tctttctctc tctctccctc tctctctaat atttaacctc ttggttgaga taagctggtg 210780 aaaatcatgg aaatgtattt ttaaaatctt cattctaagc ccccgagaac cacagtatgc 210840 cagattcctt tgagctccgc ataaatgtct tggctccgtg aaccacgtgc atcttatgca 210900 taatcctttg gttgtgcgcg ccagctgggc agcagagata gcgagtgctg gggtcttgca 210960 gctttaaaac tgtgcccagg cctcactcag aagtaggaaa atgaaatgag catttgcata 211020 atctatctcg agttacccag gtttctttca atcttcttat cacgttttta aaaaaatcta 211080 ttaagagaat attagaacaa aatgcatttt tctcttcaga gaattcattt tgcctgcgtg 211140 tttgggtcct atagggcttt tcatttgttt tagtttttta aaatgcctta agaaaaattt 211200 ttaggagttt actttgttcc tactcttctc tatttgagtc agcaacacat atttagatta 211260 attcttttga cttggaagtg cagttctgag cgattacaaa atttttatct aaaaaggctc 211320 taaatgaatt gaagttgtga aaattgtgat aatttatttc ctggaattga aatacagaga 211380 gaaactaaaa tacacaccac attttaattc agtgttaatt tctcccattt gcttataaaa 211440 gaaaacatgg tgcagatctt gtgtacttga aataactgtc cacacattct caatccacag 211500 tcacgaatca gacacacaca catgcacaca catgcacaca cacctgccca cgcacacacc 211560 ggcatacact gctaaagtaa caagcttgct ctccaggcct gtgctgccaa ggctggctgg 211620 ccagactgcc tgcctccctc tctctttctt tcttaactag attattttca ttaactctac 211680 tttctaaatc tttctttacc tcggtagcaa tttgcagctg catcatttac tgacacgtgt 211740 ttcttgaagt tccctagcag gcactgagtt ttgaaatcca gcggtctcca gtgtctggcc 211800 cgcacaccag catttggtac tgctgccctg tccttttccc tcctgctgac atccctccct 211860 ccaggctgtc tgctgtgtgt cttcgctttc tcttctttat tttccccttt ctctcctgtc 211920 gatgggattt cccttctttc ttctgccttg tctgtcccct ctctgtgtcc cttcttcctt 211980 gaatggtgac ctacctctct acaggctgtt cccagatgcc gtcattcttt catttaacac 212040 agaagtacta agaactcatc tgtacctggt gctattccag gggctggaag actacagaaa 212100 attttagaga gacaaaattc ctatctttgt gaaacttata ttccagtggg agcaggcaga 212160 caactactaa aataaacatg taacatgcta tgtttgatga aaagtgttgt agagaaaaat 212220 aactcaagga agggtgatag taggttgagg ctgtttaatg ctttaaacag gatggttggt 212280 gaaggtttct gagaggtgga cgtgggtgca aagacaccct ttcttctcgc tcagttatta 212340 ccaaaacgga aaaatcacca cgtgcctgtg ctgaagacaa ccttgtagat acacaggctt 212400 caaatgaata cactgaagtt cacacatttc tttaacctgg gatgtcccaa atatttcttt 212460 ttagatttgt acatattttg ttttactgat agcttatttg atgtattaag atactattac 212520 agagaacagg aatttctagg gcatattggg aatgaaaagt atggccatcg tgttgcatct 212580 gagctgtggg tccccataga aatgtgaaga gatgagggaa aaggataaat ctttggagga 212640 agagtgttgt aggcaaacag aaccgtaagt gcacaagtgg gagtgtagta ccactgcatg 212700 ctggtagaag ccttggtagt gaagagctga gtggggaaac acggttccgt cacaaagtcc 212760 ctctgtgtgc agacagaggc tgatgccagc tctatgccta ctgccaaccg ctgccaccaa 212820 aaattacgga cagaacaaga ggaacaaaag ccacagagct ggtctgaatc tcattcctga 212880 aacatctttc ctcttattgt tttcaaactt tctgtgtttt gaaagttctt aaatgtaact 212940 cttgtgcttt tactcctcca ttaaccgttc atcaagtcgt ctttcaataa agagacttat 213000 atgttgtgtc tttgagattc ctttatattg ggatataaag gagcatatcc cactaaggaa 213060 taaatagctg ctaggctttc tctttctttc tatttgttag gctatgttcc tgggtcgaga 213120 ataagaaata gtaaaccctt tgtgtcctcc ctttgggaga agaccacctt atacagcaac 213180 aacatgggat ctctggggcg catcattccc tgggaggctt cccaatctaa taggagactg 213240 cctccctttg ggaaaagaca accttgtgtt ttctgtgtat ggttcattcc aagttacaca 213300 catccaagca tcttacacca ttgaacacgc tctcaaaatt cactccaggc atttgcgttt 213360 tgactccatg catccccatc aaacagttct tagcctacag tcctgacgga ggcccatctg 213420 agcagccatc ttattctcaa tgtctagcta acccctcctt tcttctcact cagttattgc 213480 caaaatagaa aaatcgccat gtgcacgtac tgtacgtggc tgtggataca caggcttcaa 213540 atgaatacat tgaagttaac acattcttta atgtgggatg tcccaaatat ttctttttaa 213600 atttgtacat attttgtttt actaatagtt tatttgattt attaagatgc tatttactga 213660 gaacagcaat ttctaggaca tattgggaac gaagagtata gccatcttgt tttatctgag 213720 ctgtgggtcc ctgctcttgc agagagatgt ggaactgggt cttgctgtga gatcttgtga 213780 agtcaccgcc ttcctctcag gaccaccgcc atttgattat acgttgtgtg cattccttca 213840 cgtgaccatg tgccagatgc aatagaaaaa gtcgtttcag actgccactc tctgcttcca 213900 aaacccaagt atcacattgg ttggaatcga tgaaagtaac tgtcacccag catttgtgtt 213960 cgctggtgat gatgtattaa atagggaaga accacaggct gggaggacat cagtaaacaa 214020 cctaaagggg gttttaaata gcaaatcaat atggaacaac ggatgtagaa aattaccagg 214080 aaatggataa ttaagttcct gccatgctct tttacaaaat ctctgagaat aaattctctt 214140 aggacaaata aagaggaaaa gtgatgccca tgaaaacctt aaggaaatga ttgagtgttg 214200 gtgcttaaag tgatggagta tcggtggtgt catagtgtgc aaagggaacc cacagcctct 214260 tgaagggatt cgcacatggt cacgtccatc tttccattcc agtggcgctg ggcttcctgt 214320 ggatgcagca cagttaagtg tagtggtctt tctaaaagca ccgcacaggt gcttgtcaat 214380 caacgtggaa tgaaagccac cggcctaggg atgaagagtg agtgagacct cttgcatttt 214440 ccgactaagc aatttcagtg ctgtcgtgtg atcttgttat tccaataagc aaaacacgtt 214500 attttatttt gggctcagtg ttggatatac tgaaaacaat gataataacc agcatttact 214560 atggagcaca tactgtgtcc caggaactgt cgtgtccttt atatgtttta cctcgttact 214620 gagtgtgtgt gtaaaacagc tctttattat gtgagcagaa caactcccca atatatgtgt 214680 gatagtagtg tgtcttttaa tacatttgtg tatgcatatg tatatataaa acaactgtcc 214740 tctcaccctc cccccaccca atttcctttt attcttgtaa acgactttct ctacctcttc 214800 atttttttat ttacagaatg acaagtattc ataaagccag gtataggcag attctatcag 214860 ttggctacaa tagctggatt tgtcttgggg gtagttttat ttattatttt gccctcctat 214920 ttctgacagg ctcatgaacc cctgagcact ggggtcagca tagacctggt cagcagcctt 214980 ggaagccagc atagctcttt ggaggcccca tgcccagggc actacccttg caaactcaga 215040 gctgtaaaag gatgccctct tcaactgcgt ggacgcgtgc tgttcaaatg caccttctca 215100 cagaacctgt gcagtagcgc agggaggcag actttgtcag aattgtaccc acattttact 215160 aggaaagcac caacatgcag acagtctgaa gaacttgccc atggtggcga ggatagtgtc 215220 aaagccatgg cctctgttgc catcaccctt tatttttcct tctgcaccac aagcccatgt 215280 ctcctgatat gactgggaag cctcatgggg agtgaggttc cccacagaga tcagatgtgt 215340 tgctgtataa cttcctactt tgggacagag ataaaatgga tgacttcttt ggccctccca 215400 gtcctgagat tctatcatcc agattcattc cagtaaacat ggaacaccac ctaaatgtgc 215460 tggagtgaac agagtgattg tttccatgac tgatttcagt gtcttaattc cttctcacca 215520 attccatgac tgtggggcct gagggacagg acaaaagagt agacccaata ctgggaagtc 215580 ttattgggtt gcaggggtgc tctgagtcag ctggaggaaa acggtgaatc acccatgcaa 215640 gcccagaatc ccacccaaaa ccatgcccag aattcagaca cattttattt taaagaaata 215700 acaaaagtgg ttgaatgagg caagatgtgg gagtgaaaga ctggacctga tggtgacagc 215760 tagggaaagg aatctgagct gctagagcag ttcagtagct ggctcaatta tcaagcggtg 215820 agatttgctg gcaagagtca aataaggaac aagaagacaa atgacatggg gcagatagag 215880 ctgcactgtg gcagagctga tctgcaggct ggtggagcag aggaggggag ccactgagcc 215940 atgcagagag gccacgtata agataatacg aagtgacttg gccaaaatgt gtaagcacag 216000 aaggttcatt gctggcatac acaatttctg ctacataaca tggtgtcctt aatggccata 216060 actgctgaaa agcacaggga gaaagtggat gttatctaat ttataaaatg ataatacttt 216120 tattatccag attgatgaca gatgctccaa cccccagagt ctttctctcc ttggcccctt 216180 gacctgaatt cttcaagcgg ggacttcgtt tcatagcctc tgagcccatt ctttcttccc 216240 ccaactccct caaaaatcaa attacattgt aatgatctgt ccacctttgg gtgacactct 216300 accgtgttca tctgagactc tctccagcgt ttttgtttgt gtccaggctt ccaggaaagc 216360 tgatggggtc tacatgcact tttcctatat cccccactga caagtacagt gaaggccgaa 216420 tgctcagtga acagtaactc tctgccctaa atccaggtgg gtgatggatc aacactgaac 216480 ttttatttat ttattttttt agaatatatt actttggctg ggcgcagtgg ctcacgcctg 216540 taatcccagc acactgggag gccgaggagg gagaatcact tgaggtcagg agttcaagac 216600 cagcctggcc aacatggtga aaccctgtct ttactaaaaa tacaaaaact agctgggcat 216660 ggtcacgtgc acctgtaatc ccagctactc agaaggctga ggcacgagaa tctcttgaac 216720 cctggagaca gagatttttg ttgtggtaaa atatacataa cataaaatcc acaatttgag 216780 ccatttttaa gtgttgacta tacaccattt aaagcaacaa aaatgtttgc aaattcgggt 216840 tttatccaac aatgcatgca tttcctgtag attttattct cacctcacct ctgtatgaac 216900 tctctgcctc tgcttctgtc aaatgtgtcc gttccctaat attagacata ctttgtgctt 216960 tcctgcttaa ttaattgttt atacagccct tctctttcct tttcacttct gctttcctgg 217020 ccaccacacc tcttcctgtt gggctccatg gtagacatcc atcagcattt actccttgcc 217080 tcccagggaa tctaggtcat aaagggcacc ctctttgttt atagcactta atagtaattg 217140 taacatctct atgttgtcta tattgtcatt tacctcttct attaactatt cacatgctac 217200 cagataactt cttttattaa tctgtatgta tatgtcaggt tctatagtag atgccaggtc 217260 tccaatagta aatatgaata tgattattaa tattaaatat gatttgtctc cttttctcat 217320 ggaagtttta tactctggac aaagggcaga cattgaacaa tcactgtatc aatcagaata 217380 ggctatgttg tggtaggcta acaaccttca gcaccttcga acaacaaagg ctgattaatt 217440 tcttgcttac tccatttgcc ctggtggctc agctgtgact ttcatggtcc ttactcatgg 217500 accttccaca ctgagggagc atgctgcatc tggggaattt tggatatcag gagcactgag 217560 aaaaagagaa cacagtaagt ctcaaactag ctcttaaaac tccttcctca cttctcctct 217620 tgtttcattg gcaaaaacaa gtgacacggc cagttctggc ttcaatggtt gatagatatg 217680 taatcttccc ctgaggagtt tgggtatcgt ttaactggat atacaggcta tacatacaaa 217740 tgcacaattg cacattttta tgagactcaa aacccttcca aagtaaattt gattacttct 217800 gtttgaattt ggttttgaat tttctagaat taaagggttc gaagaaatgt ataaggataa 217860 tcttgtccaa tcccaaatgg tttgacccat gactctcaat ctctgggcct ctgcataaga 217920 gtagagacta aattatttta taggacaaga agtagagtaa acatcctaag tgcttgccat 217980 agagtaagta atatcacaca cacacacaca cacacacaca cacacacaca cacacaccac 218040 acacacacat actacacaca catacacaca caaaaagata gatatatagg gctgggtgca 218100 gtggccaggg aggccgaggc cggcagattg cttgaggcca ggagtttgat accaacctgg 218160 gcaacatgtc aaaccccatc tctccaaaaa aattacaaaa attagctaca tggtggtgca 218220 tgcctgtagt tgcagctact cagtaggctg agttgagagg ataacttgac cccaggaggc 218280 ggaggttgca gtgagctgag atcgcaccac tgcactctag cctgggtgac agatcaagac 218340 cctgtctcaa aaaacacaag aaaagataga tagatagata gatagataga tagatagata 218400 gatagataga tagatagata gcaagtgctt ataccatgga ccattctaaa tgtttttcat 218460 ctattaactc aagagtcaac aaactttttc tgtagagtaa cagacactag atattttagg 218520 ttttgtgggc catgagatct aggttattac tacataactc tgccactgca gtgcaaaagt 218580 ggccacagac aatacataaa caaatgatct tggctgtgtt ccaatacgga tttatttaca 218640 aaaacaaaca gtgagctggt ttgacctctg ttttaactta gtttattctg atgacaaccc 218700 tactgttatc cccattttat agaagaagag gcctgtagag gtacagtaat ttgtagaagt 218760 gcagttgagg cttgtagagg ttcaatcatt tgtcaaagtt ctctcatctg gtaagtgggg 218820 gagccaggct ttcacaaagg caagttggct ccagggttca tgatcccaac tgttaggatt 218880 catttcttct ctaataatgc tactctgctg aattcagtta agctatcgaa gtatggatca 218940 gaaaagaggg ttgggcttcc aatatatttg ctcattttat ggatgatctt ttctgtctac 219000 aaagacaaaa gacacaaatt atttgtggtt tcattgtgct ggggttgtgt gatttactga 219060 gccacactaa atacacaaca aggtggtata caaagtggtc aaatgtacca tctgaatcat 219120 tcttgacata cacggacaca caactttggg ggtcttcaag tttccttcta cccttcccag 219180 cagggtagaa gagaagacaa aaacacagca gaaaaactct gtccaagaat gggaaagagt 219240 agttatggca tgcttaggtg gtgggaaaca gctgatttaa agttagtaaa tctgaatcca 219300 aataatggtt cgatttctct gtgcaaccat gcttaaatcc ccgtgcttct ccaaatcgga 219360 gctttcacgt ctgaatcatg gagatagtat atctactaac agatgtgctg tgaatgataa 219420 aggagtttaa gtaagtgcaa gtgttggcta aattacagca tcttatagat atatgtaaag 219480 tcatcgctat tactggattg tccttagaaa taagggtttt gcttttgttg tatttcaagg 219540 tgacttaagt atggttgact gcatatagaa aaggaagaat ccaaacatgt actcgctgta 219600 attgagtctt taaattgcat atttaaagaa aattactagc ttttaaaatc ccaagtgatt 219660 ttagagaaga ctcacagaat tgttaaggct ttccacaaca tatttactca tatagtgggg 219720 gtggaaggag ttggatttgc ccttgtggtt ttcatagagt tgacagcttt tcttgcctat 219780 tccacaagtt ctaatgctac ataattttta agatttggtc cactcagcta tcactgtgat 219840 ctcccaactt aaatctgtta tcaatttttc agtcctctcc tagttctttg cattcacttc 219900 tatttgccac aggttattag agttatttgt ccattcattc aactaacgtg tggctgtcta 219960 ttatggagag gcagtgtact agatgttagg gacacaaagc tcatgaagta gatatggctt 220020 ctgtcctcag tcggtgtatc tctcagtcag aatctgttac ttgagggggc agctggagct 220080 ctttctccct tcctagtagg ctgagcatat ggaaaccaga ttcccagtta attttagttg 220140 ttgttttctt gatacgtaaa gaaaagatcc ataaactcaa gatgctttct tatgaatcaa 220200 gttttcaagt tttatagcat tcgctttgta ctacttgttt tgaccccatt gagaagtttt 220260 atttcttctg ttctcctgat tcttcgccat tttagcagca aatatgtact taccatccac 220320 tatgtgattg atgctttgga aatacaatgg aaaacttggt agcaatgaac cctctgcctt 220380 taagaagctt atattctatt ttagattagg gaagcaggaa ggtctctcta tgtacaatag 220440 aatgggaaag aacgagccac ataagtggtg tcaaagagga atgcaaaaag acagcatggc 220500 tggagccaag tgaaactaaa aagaagatga ggttgactag agacatgatt cagatcacca 220560 gaggctggga ggcaatggag agcattttga tttgattcta agttcaatgg aaagtcacca 220620 aagagttcta agaaggagta taacataggg tttgacacag tgggtgggtg aagaagatca 220680 cacttgctac tagagatggg gagtacgttg tagaggggaa agtatgggtg cagagagatc 220740 agatgggggt tatttcaggt gtctacataa gggatgatgg tgacctcaaa tggaagtaga 220800 ggtaagtgga gagatgtgag atacattttc agatagcagg agtaggacct gctgatgggt 220860 gtgttgacat gggctgaggg cagggatgag gcaggaagat ggtaaaatca agaatattcc 220920 tgggttgcgc aacactcctc tgtccactcc ctgtgatgcg atttggcatt tcccaactct 220980 gccttccctc ctaaaaatca ggaatcggtc ttatattaat tttattttgg gttctgtatc 221040 tgttgaattc cataaacatc tctcattttt ttctggttac tcattcatct atcagaaatt 221100 gtgtaaagtc catatttttt caaatttaga cacctaaata ataaagattt aaactattaa 221160 taaacatgta cttaatttca aaaagagcct gctagacata ggtgaatagg gtttcccatt 221220 tcccgagagg aggaagaggt gaggaagatt gtgtggggaa aattgagagg aaaatggagc 221280 agtagtaaag gagaatgcca gctaaaggga attttgtttt gttgttgtta tttgtttatg 221340 tgttttttgt aaagatgaga tacagtagag catgtttgcc cagtgagtac agtgatccaa 221400 tagagaataa gctgtcgtgg tgcagataca agaaagataa aagaacagac gtaatgacat 221460 ccttgagaag gccacagggt gggggctttc cagctcctgc agcaggatcc gccttgagtg 221520 ggtgattggg gtgggtgcag ggtagagaga gattctaact gagcaagttt aggatgaggg 221580 cttgcactcc agaaaaggct ggagaaggca ctgagagagc tgttaggagg gaagccagag 221640 atgagaaaca tagaatctca tctcagggag tgaaaaagga gactcctaga cacaggatgg 221700 tgggcctttg ttgagcgact cttccataga ggaaagtgcc ggatagctgg tttctggaga 221760 atttaagtat tactgtatta tacattataa tgcatctttg tataatgttt ttctcttatt 221820 ccccaagatc tttcattttc ttttggaaaa tgtggacagt tagtctccat gtatatctct 221880 gtggtttctt actcttatat taattttgtt ttgagttgaa tatcaattga acttcatcaa 221940 catctctcat tttttcaggt tactcattcc tgtttcagaa attgttcata aatgttcatt 222000 attttcacat ttggacacct aaataataat gatttaaact aaacatttat ttaacttcaa 222060 aatgtatata ctatttgcct tttttatggt gagaatatat ttgtataata cctatttatg 222120 tcaacacagc aactaacata ataaatatac tcttagatta taaaagctca ctttatataa 222180 tcaaagaatt ttctttatgt tataaaataa ctggtatgaa tatgctattt agattatcat 222240 tcaattactt acacctcatt tctttcaaaa tgtattggag atatttccca atttgcaggt 222300 gcttggaagg ttggagtgat gagtgtgtgt ttgtgtggat gtgcttttgg atgtgtatgc 222360 acacaaaggt ttcttctttc ctaatctaat atttcttttt tcttttttgg cctgacttct 222420 atacacaatt ttcttagccc ttctggtagg ttatttagga actcaaaagt gctgggtatt 222480 ggctttcatg tcctgccagc cttccttctt ttctttggga gaatgttctg cattccagga 222540 gaccctgctc ccaagcatca ttcacatggt caggctgtcc aggtgcctct caccccactt 222600 ggagatgagg ctgctctgtt ttcctacttt ggtaatccct gcctctgttc taagggcctg 222660 gccaaaacat ggaaagtctt actctttttt caatccgatc ttacagcagt gctggtgaca 222720 ttttattcta ggtagatgtt tgcatgaggc agttcttaaa aaaaagttta aaaaaagatc 222780 tttctgtctc tgagcttttt tcatctattt cctccttctg tcatatttcc agaaggtaat 222840 tgagagtcag ttatgtttta ttttatttta acccagtgat acaggcaatg atgagtttgc 222900 atgttagtaa aatgggaaaa tgagatgtgt agaggctgag gggcaaaatg agaatcggca 222960 caaaaatctg attgatacaa cattctgtga gaggcaagaa tgtccctgtt aggcaggaag 223020 ccctgggtaa gataacctgg aatgggtgta tatgatcaga acacagggca aaaaaaacca 223080 tcctcaagac ttatcgccat atgaagactg aaagacaaac caaccttctg agtgaactca 223140 ctgaaaaaaa tcttgtgtgc ctggaaacat tctgaaaggg gcccctccct tgggctataa 223200 aatcaatggt gaatatcatt atcaaatcag atatgggtaa gcttttacag catccagttc 223260 ccagtgacta tcccttaaag aacaaaacaa aacaaaaaca ccactatccg taggcaagtg 223320 ttttctcttg accacatatt tacatatgaa agtctattct ggggaaggac agtgaggaag 223380 atggaaaaat caatgaaaag ctccctcttt gaatttgtag aggcctttct ttcaaaggtg 223440 agcccttctg cacagatttg tttgcagaga cccacacagg ccccatattt atttagttcc 223500 tatttgaaaa gaagctttcc tcctgcctta gaagaagctc attacagata gacttcacct 223560 ttctgttgca aaagatgttt ccttgaaatg aaaatgtaat gagtgttaga tcagtagcat 223620 gtagctgcca ggctatctct ttgatccagt ttggaatgca tttgttaaaa agctgcttta 223680 ttgatttttt tagctgcttt ttgctgtgtt tggatcattt gtacatatac acatcacaat 223740 ttttgctaca tcaaagtgct taataagttc actgcactca ggaaatagca tacaaaacaa 223800 aggaactttg ctctataaag atttctgcct cttaacctcc agtatgaaag ttgtttttaa 223860 tgtgtttttt tttttctgaa tagcttcaaa atattttatg cagtcttcaa tgagtcagcc 223920 agggccccgc ttcagatctc cttctttgaa aatgatgcat tctggaaaag gaaggatttg 223980 attgaacgag taaacacatc tcacatccat tctgctggac aggagtcatt ttacttcaat 224040 taattattta attggctcaa tttgtgggta gcggcagctt ccaggaaagt gttgacaata 224100 tttgatgtat gtgaggatag ctactaattt agtaataagt tgaaatttac taggtaacta 224160 atgtgatgtt tgtttattag gtccaattat atgacaaaga atgagcacat tataaccttt 224220 aatgctgatt tttttttttt ttgtatcatg tacatacaaa tcagtgttaa gtgcttttaa 224280 ctctaaacag gtatttcctg ggggcagact cggagccagc tcagtggaaa gcacgactgg 224340 gaagacagag ctgagtttgc tccacttttg gtctcaggcc aaaagtgctg actgtggtca 224400 agtgtgggct gcacagagga gctgtccaat ccagctttcc aactagaccc ctcgtgctgg 224460 tattcgggca ggctatacct cctgcagatg tacaaatgaa catgcattaa agattttatt 224520 tacctcattc agtgagggag ctaggaaaac attataaaca gttgaaatgg ggatcaaaac 224580 caacatttat ttgtcagtaa tagtgaaatg aatatgcaaa tggagtcaaa actggttttt 224640 ccatgggaat ggtgtcggtg gggagggaaa ccaattaaac ccctatgaca ggtggaattt 224700 atggtgttca ttagttacct acagactata ggtttgtaaa atagctcaaa gacaatgaaa 224760 acttagaatg tgataacctc tagagtctag aaattgtggc gcttcccatt gaagcacacc 224820 tttttttgta cacctccaac agtggggcgg acactcaaat ccttttcttt ttgtctttaa 224880 agtcaggaaa gtacgttgac ttcaggggtc aggtgaaggt caaggggtaa gaaaatagga 224940 ggcaggtgat aattgtgggc ttccagtaat attctggtaa gtgaaaagga aacatgacct 225000 aaaatagcaa tgcatcaact gagtatttaa aagtcttttg tcttttctag aaattttgtc 225060 atcgtggtgg tagttgatgt aaaaagtggt tttcctactt tgaattttat cttttattct 225120 ctctctctct tttttcccct ccctcctttc tttccttcct tcctttcttt tttcttcctt 225180 cctttccttc ccctcccccc tccctccctc ccttctctct ctctctttct ttctttcttt 225240 tccatgacct cattcagtgc cagttcacat tttcatcttg atccatccct ttgtacattg 225300 gactctcaaa aacagcaatt cttaacagct caattggatt tgccatttgg ggccatctct 225360 gtacatggcc tctaaataaa tttacgaact ccccttggtg caaaattgag atatagatga 225420 atgggtggct ccctaagaga ggaacgggga cacctgggtc tggtggaacc atgtcctgaa 225480 agcactatat gactttggca aacagcactc ttctctgggt gccatcccat ctggtcccca 225540 agcagaagtc agagggtgct tagcagccat ggcctggcct ggctgcaaag ggcatccagt 225600 cagcattgct ttgtacactg gagctttgaa ccagtgatcc tcaagcctct ccagtcaggt 225660 cactgggaat ttatactttc ctaaaatgtc cgttttcttg ctgtttgcct cagaatgaaa 225720 tctcacctca tgtgatagta gtcatgaaac ccaaagacac aatgtggaga ggagttcacg 225780 agaatgcctg gtatgaggag agcaccccaa atcactcttt atgagctcat ctcaaatctc 225840 gggctccact tatcccacgg tagttttttt gtttgttttt ttgtagttat aaagatataa 225900 tttacatgta ataaaattta tttttaatgt gtatttcttc ttttgaacat atgcttagag 225960 tcacactaca atcagataat gtttctgtgg gacacccaaa ctttcctggt gccccttttt 226020 tgtcattttt atccctggtc tcccaacttt agtaaccact gttgtgattt ctgtctctat 226080 attttgcttt ttctagaatg tcatatcaat ggaatcctag aaatgcaaac ttttgagtct 226140 ggcttctttc acttataatg catctgagat ccatcaatgt cgtcacacgc atcagtgcac 226200 gctgagtcgt attcccttgt ataaatggaa cccggtttat tgtctcacct actgaaaggg 226260 aggttgttgg gttgttttta gtgatgggac atcatgaata caaccagtag aaacgttcat 226320 ttacagattt tttatatgaa cacagtgtag tgtttctgaa ttggatgata aatacgtgtt 226380 taattctata aaaagctgtc aaactgtttt ccaaaatagc taatctattt ggaattctca 226440 ctagcagtat atgagagttc cagttgttcc atcatattct caccatcatt tggtattgcc 226500 tgcctccctc ccttactcaa tcttcttttt tcttttcttt ttttccatta tattctcacc 226560 attatttggt attgcctgcc tgcctgcctg cctgcttgcc ttcctcccct ccctccctct 226620 ctctcccttc ccttcccttt ttccttcctt cctttctttt cctttccttt ccctcccttc 226680 cccctccctc ttctctccct ccctccctcc tttctttctt tctttctctt tctttctttc 226740 tttctttttc ttttttctct ctctttctct ttctttcttt ttcttttttc tctctctttc 226800 tctctctctt tctttttctt ttttctctct ctttctctct ttctttcttt ttcttttttc 226860 tctctctttc tctctctttc tttctttttc ttttttctct ctctttctct ctttctttct 226920 ttttcttttt tctctctctt tctctctctc tttctttctt tttctttttt ctctctcttt 226980 ctctctctct ttctttcttt ttcttttttc tctctctttc tctctctttc ttttttctct 227040 ttctctcttt ctttcttttt cttttttctc tctctttctc tctctctttc tttctttttc 227100 ttttttctct ctctttctct ctctctttct ttttcttttc cttctttttc tctttttcct 227160 tttttcttcc tttcctcctt tcttgccatt ctactagatt tcatagtgtt atctcatacg 227220 gtttaaatga tattacctta attactaata tgttgagctt tttttttttt ctttacatgc 227280 ttaaaatctt ctctgttcaa gtgtctgttc aaatcttttg actgggctct ctttcaaaag 227340 ctttccaatt caaattctat ctttccaaaa atatgaattc attaagtcta gaaagtatcg 227400 atcggcgtat ttacaatgcc tgtggatgca atggcgaaac aaactcctag aacagattat 227460 tttgtagtac cttaatacat agatattaaa gcagtaatca actcaagcca gagtggattc 227520 actaagaatg aataatgtaa agggacccat ttcctttctt tttcatgaat taacttaatt 227580 ttatattaga atagttgaat agatatattt tatttcatgc ttgtgaacaa aatggagaaa 227640 tatgaactgc gtaacaatag gtaaattata ttttgttgaa aaactattac cccaacatat 227700 taatcttttt gaatctgtct agctggagga atgttcctta gtaattaaat tcaaaataat 227760 gtaatcatca aaaatattcc aattaagtca acaataattg ttttataaat attattaaat 227820 gtgtatattt tattcttatt ttagaaatat cacatattat aataaatctg gtatagtttc 227880 atgggagaag gatcctctga cattcatctc agaatgctat acttcactta aagtttactt 227940 ccttttgtta tattaacccc acttcatgag atgctattta ctctactttt tttaaatgtg 228000 tatgcctcac tttaatggtg ttgcttttgt tttttttaaa attgcttatc tttatatttg 228060 agctttcctt ttacccggtg ggtttaagtg gcatactgct tgcttcagcc tatttcgagt 228120 aattctgagg tagaggcagg acagattgcg aggcctgtca tgccaggagc tgcaaagtct 228180 ctccccttct tcctgggtct tggtagacac ttgagtttct gccatgttgt cccttccacc 228240 tccaggcgct gctcctgcct gagttctgca gccaagtgcc ctgtgattgc tataagaagg 228300 aggaatgagg actggggggc ggcgatgcag caaactgacc agctgccacc tctccattct 228360 cccagtcaat ctctctgatc attgtctctg cgctagctca cagtctggaa gcttggagag 228420 cctcttttgt ttctccactt tttttttttt ctcagagttc tctgtaaaag catgttttgg 228480 gttgtgctct cctgtttcaa ttaatttata tctaccctct gacttttagg aacttattat 228540 attatttgac aaagcacaaa tgtgcagaaa aatcctaggc ctaataaacc cagatgttct 228600 ggatgcagat tcatgcttct ctctcatgaa actccgcctc ccaggccatc agggtgaaag 228660 cagggtggca gctgctgtga ggacagcgct gccatgcagc gctagagacc attccccaca 228720 ccgcacctgc tgccacggca acaagcaccc ctcctgccct ccccctttag aggatgtcat 228780 gtggaagttc cataaaggca aagaccacgg agagctcatc agtggatttt acccagtaac 228840 attttaaaat gtatttattc cttcttcgtt tggattttct gaaaacggag cacacatttc 228900 gataggcatc aagcagcctg ttgatttcat gtgtactaac tagcaatttt cttcttatca 228960 gagatgctta ttgaaacacg aggctttcat ttcttaatac aatgacacct ttttaatcag 229020 tcccgcacag ctcttaattc aggagccaga atgtcagtga ataaagttct ccttagaaag 229080 cagacctgac aattcctatg gttcgtgagg cttcaccttc acccaggcag ccatattgac 229140 aaaagcccca agtgtgttgc aaagtgggtg ggtgccggtg ttttgcctgc ttcgcgttgg 229200 aacacccgtc ctctgtctgg cattgctctg cagtaggaat tttggtggga aggaagaagt 229260 tgcagaatct gagtcagcag agtctctatt tctagatgtg cttgtagcta ctctatggac 229320 acctgaccta gcttcttcta agtcagtgct cctcaactga gcacaagttt gaccccagaa 229380 gtcatatggc aatgtcagca gacagtttca accataacga ctgggaggga gctgctggca 229440 tttagtgtgc aaggaccagg ggtgctgctt acgcatacta tgatgcatag aatgttccca 229500 cgaaaaacaa ttgtctgact ccaaatgtct acagcgccaa gcttgagaaa ccctagtctc 229560 agttacagta cctgggagcc agtggatctc cagtgtcctg ctcgggtcct agaaggagct 229620 gggagggggt agattgtggc ctctggtgtt ctgtgatggc agcagcaaca tttactcaag 229680 actcattctg ggccgggcgc ggtggctcac gcctgtaatc ccagcacttc gggaggccga 229740 ggcgggtgga tcacgaggtc aggagatcga gaccatcctg gctaacatgg tgaaaccccg 229800 tctctactaa aaatacaaaa aaattagccg agcgtggtgg cgggcgcctg tagtcccagc 229860 tactcaggag gctgaggcag gagaatggcg tgaacctggg agggggagct tgcagtgagc 229920 cgagattgca ccactgcact ccagcctggg caactgagca agactccgtc ttaaaaaaaa 229980 aaaaaaaaaa aaaagactgg ttctgtgcct ggcctttgtt ctgggtgttg gcttctgcct 230040 ggctgtctta gagtctattt ctggtgtctc ataaccattc tttttttttt tttttttgag 230100 acggagtctt gctctgtcgc ccaggctgga gtgcagtggc gggatctcgg ctcactgcaa 230160 gctccgcctc ccgggttcac gccactctcc tgcctcagcc tcccaagtag ctgggactac 230220 aggcgcccgc cactacgccc ggctaatttt ttgtattttt agtagagtcg gtgtttcacc 230280 gttttagccg ggattgtctc gatctcctga cctcgtgatc cgctcgcctc ggcctcccaa 230340 agtgctggga ttacaggcgt gagccaccgc gcccggccaa taaccattct taagttccgt 230400 gactcactag aagggctcac agggctcagg gagactcagg actatggttc attacagtga 230460 aaaaacacgc agtggcatca gcaaggaaaa caaatgcacc aggcagtgtc tagaggagac 230520 ccagcagtgg cctccaaagt cttcctgtgg atttgcgcaa gacacactca ctcctccagc 230580 aatgaacttc agtgatgtaa gccaagtgtc taagcccagg gagggcagct tgggtctcag 230640 aggctagagc ttttatcagg agctggtcac acaggcacct atttccagga ggaaacgtga 230700 ccaccgtaaa tcatgctatt gacttggtac gaaccaacta gataagcttg ggcagcatgt 230760 gtcaggaccc cgggtgtaca aaacaacctt attaattagc agcgcaggga atattgcagg 230820 gccaagtttt caggagctgg ccaagggtca gttaggcctt cctgaagaga tgtgagactc 230880 tggcactgtc aggcagctag ctctttcctg cacactgcag ttgtcaaaaa cttcccagtc 230940 attctgtgct ttcttcagta acctttcagt gaagcccttt ctgctaaagt cagacaagtt 231000 cagttatttc tgcttccaac caagaacagg agctgactca tacacaaggt aattcaaaaa 231060 taataaccga ggcctcttgt gttgtttgca tggatcttgt atgcatgtgt gtgtgtgtgt 231120 gtttgatttg atttcaaaac gttatcattt ctatcagaaa gggagctttc ttgaagactt 231180 catgacagcc acacatgagt ccttgggctg gtgttctagg gaagcacatt atctgcccgt 231240 ggcctttaat gatatgcatt taaaatattt tttctttttt taatagagcc gaagacccag 231300 gacacaggca aagactgccc atatcacatt tttgacgttt gttgatatag agctctctgc 231360 ccaggaaaga ctttagctcc atctgtctgc atgttattac acatcccagg ccacttaata 231420 catccagctt agctgtggtc tgaggtaccc tgcttttctt aggtttgaaa tgaatgcagc 231480 tcatgcatgt aagatgtgtc ataatctctt aggaagcaat atcaccactc aaaataatga 231540 aagatctcgg aaagaaaggg tacgaatttg ttggggaata tttagccatg ttgtctgact 231600 ttcttaccca ccacgttttt tgtttttcag agccattgaa gataatgaag agatcactct 231660 taaagtgctc tttttttctt ttcagatttt aatagtaaag cagaacttta aaaaaaaata 231720 aagctgataa aaattattca tagattcatc atttagagaa aattgctgtt aacattttgg 231780 tatataatat tcccatcaat tttcttttct tttctttttt tttttttttt ttgagacaga 231840 gtctctctct gtcgcccaga ctggagtgca atggcatgat cttggctcac tgcaacctcc 231900 acctcctggt tcaaggcatt ctcctgggtt tacaggtgtg tgccaccatg cctggctaat 231960 ttttgtattt ttagtagaga tggggtttcg ccatgttggt caggctggtc tcaaacttct 232020 gaccttaggt gatctgcccg cctcggcctc ccaaagtgtt gggattacag gcgtgagcca 232080 ctacgcctgg cccccatcta cttttaaaac gtgtgtgtgt gtgcacatgc atacatatat 232140 acataatgta tataaaatat ataataaaaa cataaatata tatttataca tgtggcataa 232200 gtgtgtgtat atagagatgc atgcacaggt agtcataatt tatgcagcaa tttatacata 232260 atgtatatca tgtaatcctg ttgatgttct tctgaaacat gtgcctgttt cattgatacc 232320 acatcgacct gcaatattct tctgcatcat ggaagaatgt agaatggccg catggtattc 232380 catctcatct catacgatag tcagcacttc cgttactgga catacaactg ttaccattta 232440 tttgcagtca catgtcaggc tgtgattaac atgtttaatc aaatctatgt gcatatataa 232500 ttttacctcc agactatatc ttggtggtag aatttctgaa ccaaagagtg agcacatttt 232560 tcaaacaatt gaaactcatg gccagttatc ctccataaaa gttgttccaa atttcacaca 232620 gtaggtcttt tttcccatga acttgccaat cttaatgatt tctaattttt aaaaaatctc 232680 aacagtttgg tgtttgtaag tagcttttca ttataattaa aacaaccttg attgttaagg 232740 agtagccaga aaccctttaa acaaaacctt actggtattt tttgtttgtt tgttttaaat 232800 caggatgtca gcctgtttaa atttaccaag tacatgaaaa ggaaaacaaa acaaaaattt 232860 cttgactcta aaaaaccctt agggtggtct acagcctgca tctctcttcc atgacttcca 232920 tgactgcatc tgacttccat ggcctcatga ctgaggcctg gggctgcact cagcaggaca 232980 ggccacctta ggctgggccc ccgggggcag tgccaggatt gggactgggg tgggactggt 233040 tgacaggagt cttctcaaat tatctgtgca tctcacaggg gaatatatgg gtgtgctttt 233100 ttcctttgat aggatggatt aggaggactc agagtttttc ttttgtgcaa ggataacgat 233160 ttgctcccca aattttgatt gtctcatact cattcctttt ctaattatcc catatttgtt 233220 aaatacaaga taatagattc tgacaagcaa tcagcaaatg ggcaccaagt gatgtgcttc 233280 attttaattg gattgccttt tttttttttc cttctctgct aaattatagc ccatcagcat 233340 gagattccct gtggtgagca gctaataata tgcccaggtg cagccaattt tacttcctaa 233400 agaagaacta gtagctacag atccccctaa agtgaagtgg aaaagtgggc tgtaatagct 233460 cgtctcagca gtgcggcatg ctagggcaac ttttacatcc ggatctctat tctaacaatt 233520 tttttttaat gcagtggcaa ttaatttgca ttatattgat gaattaatga ggcacaggac 233580 agaaggtttt cttagagact tctgagaaat ctcttgttta attttgcctt agatgttaca 233640 atttttaaaa aatctttttt ttaagaatta ggaatataaa accactatag ataaacacaa 233700 atgaaaatat cactgttaaa tgaaccagtg aaacagcatt ccatatgtat tttccaaagt 233760 ggtgctggga tgtggctttg ctttggtgca caaaccatag acaaatgtac ccaatggaat 233820 gtcagttagg tttttgggaa cacttttccc tatttgccat taataatgtt tgttcctatt 233880 taaaacattt tagtgacttt taattagcta caatgaggtg agagtatatg ttttaatctt 233940 tatctaactt aattttattt ttaagccact tgaccatgat gtgcagtttt cagataaacc 234000 caaatattct ttctgaggct gaatcaatag agattttcgt catcacatac tacacaccat 234060 ctgtcacagc catctatctg ttactctctt ggtcaagtgg ccaccaatac tcttgagcca 234120 acttgaaaac atatgggaaa gacagtaaag ggacaaggat taaagattcc tgtcttaatt 234180 cttgaacctg gaaagaaaaa atgaaggagg agaaaacaga aatggagaaa acaacaatct 234240 cccctcccta ccaagacagg gagggttttc agggtgacct ctcagtgtgt cttcactcag 234300 ccactgcctt ccatattcct gccacattct ggttcagtta ctattgtcca cacatgtcct 234360 tcttcccttg cagtttgtcc atctccacac ttcagccaga gggattatca aaaccctttg 234420 ataacatata acagacatcc tcatgctgta taacaaacat ccccttaaaa ctgccattgg 234480 ctatgtttgt aaacatgaga tttggacagg actcagtgga gcaactcccg tctgctccag 234540 gatgcctagg acctctgctg ggtagacacc aatggccagt agacagaaat ctctttctcc 234600 tcgcggcaaa tctgacttgg ggatttgtag aggtcattgt cattcatgag ctgatatttg 234660 cttctcttca gctcattgcc aagtgtccca tccacatgct atctctagca tggtgctttc 234720 tgggtagtca cacttcaggg cttcaagaga atgttctccc aaagactggg gtggactgca 234780 aggcttctaa ggacccgaac ttggagatct caggacctca catccaccag attctcttgg 234840 tcaagcaagt cagtaggacc agtcagaatt caaagagaga ggggaattaa attataaatc 234900 tcaatgagca gagcagcaaa gaacttgaag acatatttaa tttctataaa atcgtgttgg 234960 atcatgtcac cctctaagcg tacaaccttc caaggcttcc cattgctttt cagatagaat 235020 ccagcactca ccccaaacag cctgtatgtt cctgctgacc agactcatct cacaatgtgc 235080 tctctgagtc ctgctctgtg tatttcaaat ccactgatcc tttatttctc taactatggt 235140 ggttgtccca cctcatgttc ctctctttgc acactgttta gctaaagcca agctatcttc 235200 caagtctctg tttaaatgtc acttagtagg ggcaacctcc actgacccat gggtgcagtc 235260 aagcttccct gtcttagcat ccagaattat caaataatta gttgtgtgat ttagtatatg 235320 cttcactgaa gtcccatgag ggcaagggca tagtgtgtgg ttcagagcta tttgcatagc 235380 acctagaaaa ctgtcctgca cacagttggc acttactaaa tatttactaa tgagtcaaca 235440 ttacattagc caaccttagg aaagagtgct tacctgtgca tctcaaatga caccaacttt 235500 gtgaaataat agtctcctga gacatgctgg atctgcacca tccagtaggg tagccctggc 235560 cacacacagt gttgggcagt caaagtatgg ctggtctgaa ttgagggtgc cataaaatac 235620 ataccctttt tcaaagacat ggtgtcacat caaagggtat caattgtctc attgatattt 235680 catatgaatt acatgtggaa atgataatag ttttgatacg ctgtgttacc taacagtatt 235740 attaaaattg aaaactaggc cgggcacagt ggctcgcacc tgtaatccca acactttgtg 235800 aggccaaggc aggcaaatca tgaagtcaag agattgagcc catcctggcc agcatggtaa 235860 aacccagtct ctactaaaat tacaaaaatt agctgtgggt ggaggcgtgc acctgtagtc 235920 ccagctaccc gggaggctga ggcaggagaa tcgcttgaac ccgggaggca gaggttgcag 235980 tgagccgaga tcgcgccact gtactccagc ctggacgaca cggtgagtct ccatcccaaa 236040 aaaaaaaaaa aaaaaattga aaactaattt cacctgtttc tttttacatt tttatatgac 236100 tttttgaaaa tctgaaacca catatgcagt tcacatttat gtctcatgtt atattttgtg 236160 ggacaaagct gctctgaaga gaaggttcta gggtgaaatg tacttggaga aattctgcaa 236220 gcactctcac tctttagagg gtttgcaatg aacatatcaa aagccctgag aagtcctgca 236280 gcaaaactgc tgttaactct aagccagtgc atttcaaagc tgactggacc ttgcataggt 236340 ctcatctttt taagaccttg gatattcacc tcccatgaaa cacacttagg gaaacatgat 236400 taggtgacgg ccaccctgat gcctggccct gaggtcgtgg acatggttca tgtaaaactg 236460 aatcttatta tgcagattag aggcagagcc tatggaagtg catttttatt gggggagggg 236520 aggggatgga atcagacaca ggagaagtgc caaattcaag cactttggca gaatcacaca 236580 gccccacaca taaagtcgta taagcacata tgttcccacc ggaagctgga agccgcttct 236640 actctgatgg aggggatggg gccttgccag ccccagggtc atgggcagcc cgtgctgggc 236700 tctttacaga catctagggc tgttccttgg tttgccttat ttctctagtt tgctcagttt 236760 gctgaagggg caaaccaaag gtaggacaca agttcaggtc cacaacggct gggtgcagtg 236820 tccgagatgg aggggagaaa tgtacaccga gtggccgtca gggcagcaga tggtctgcaa 236880 tttcctccca gaaatgtggg catttttttc tttctacagt aaagagtgga tattgtctcg 236940 ctgggctttc tgaatttcat ttttgatgag agatttaaat atgctgtttc tcagcccaga 237000 atcctcgaga tgttcgtgtg gactatgtcc caagccccgt gcttgtttta aaggtgtttg 237060 gttgtcaaga aaggtatcct gtgaacctaa gaaatagtcc gtctccctat gaggcaggat 237120 tgtggcctct tttaaattaa tcccacgtga actgtgacct ctttgttgga ctgtcaccag 237180 aatcatcttg atataagagc actgagtaat aagaatctaa ccagagcttg aggcagccgt 237240 gatagtctca ccaccatctg cccatcctgg agctagactt tcccaggcaa ggcctgcctg 237300 tcctctgtca aagcaaatgc tggcctccca ttagctccta attctaataa gggtttctat 237360 tttatccact tacctctcct ccagttgata tttcccaaca tcttttttac catcttcccc 237420 aacaattcag tcctaacaat gctctcccct tcctgagtca tctttccttt tctcacagaa 237480 gttcatccct tccacactgc aggattagaa agatcactac cttgtgttat tctcacagag 237540 cagagatgcc aagcatttcc ccacaagcat aaatcttaat tgccgtcctt gctacaaatc 237600 ataaataacc ctagcccagg tatcattgca cagaaagcca ggcaaaggag acagaaagcc 237660 aggcaaaaca taatgaaaag gtattaattg ataactaaac aggtgttcta tcttgctcca 237720 gtacaaattt tatggcaaca attttgttga attgcttctt ctggcattga aaatttcata 237780 tgatgtgcat agtttcactc tttctaaacc catctgggga aacaacaacg gcaaaatcgt 237840 gatttaaaaa tctgaagcag gctgggcgcg gtggctcatg cctgtagtac cagcactttg 237900 tgaggccaag gcaggtagat gacttgagtc caggagttcc agtccagcct gggcaacatg 237960 gcaaaatccc atcttttcta aaaatacaaa aaatagctgg tcatggtgtc acatacctgc 238020 agtccaagct atgcaggggc ctgaggatgg aggactgctt gagcccagga gctcgaggct 238080 gcagtgagcc atgattgtgc cactgcactc cagcctgggt gacagagtga gaccctgtcc 238140 caaaattaat taattaatta ataacaatct gaagcaattc aacttattca aaacacttta 238200 cccagaaaga acttgcaaat tacccagggt gaaaacgagt ggtagctcct ggaattaata 238260 accttaaatt taaagaagag aagaggtccc tggtacactt caaaccaaaa ttgttgtatc 238320 ctttaagagt attgcaaagt taactttcta aatatgtgaa tttatttaaa tttcccaaca 238380 attaaaatga atcaatgttt cccaaattgt gttccattaa atacttctca gggagagttt 238440 gaaagttctg catttgaata tgggctttga tggtcaatag acttgaaaaa tacctcatag 238500 tagagatcta ctaagaatac aacgcataca agcacactaa aagtgctgag atattctgtt 238560 gtcaacacac ctgtttcact tcagctaacc ttttccagag cttatctggg cacaaaacag 238620 tttattttga gctgtatctc ttatttttcc ttagaacacc gtttaggaaa tgagaaaata 238680 tacaatgtta cctggtatac aatggcacgg tttctttttt gttactctgc tcaacacacc 238740 taaccatttc tccctaattt taattttgca tataatcaca ggatattttg ctgttctttg 238800 cagtttcaaa tatattttca aaatattaat ttttatccct aatgccagaa aaatacactg 238860 ctatggcatt tcaaaattgt agccatgaaa tagaatgaga tgtgatgtca tcacgttttt 238920 aggataattt ctcactgcca ctagaaaaat acttcagcag aattcatgag gattatgtat 238980 attttataat cagtctcctc ctaccattta tggtgctctt tagaggtgat aattctgtct 239040 tttgaagatc tctggatcac aggaacaaga gtgatggcaa caccaagagc aagccagggc 239100 cctcctgaaa ctcccccctt cctcactcac tcttcactgc agcctctgag aagggacctt 239160 ggccctgtac caacttcctt ctccatccaa agtggcacct atggaatggc gcctctcaat 239220 gtgggaatat tctaaccaat tgctttgtat tagttcatta ccttgctgct gataaagaca 239280 tacccgagac agggtaattt ataaagaaaa agaggtttaa tggactcaca gttccacgtg 239340 gctggggagg cctcacactc atggcagaag gtgaaaggca cgtcttacat ggcagcaggc 239400 aagagagaat gagagccaag tgaatgggga aaccccttat aaaaacatca gatctcatga 239460 gacttattca gtagcatgag aacagtgtga gggaaacccc cacccgccca tgtttccatt 239520 acctcccacc gggcccctcc catgacacgt gggaattatg gcagtacaat tcacgatgag 239580 atttgggtgg ggacacagcc aaaccatatc atgcttcttt tcatttttcc cctaaagaaa 239640 gaatatcgct ttctaaaaag atgaaatccc tgaaaagatg gaatttattt cctaaaaaaa 239700 aaaaaaaaaa aaatcagaat taaagggaga atgaggcata tgaaatttgg atccaaataa 239760 cttgaagcac atttcttata tatgatgttc tttgtagaat tcctttgact gattggaacc 239820 atttatcttg ctgtgatttc acagcacagg cataattgtg attgttttat tagttctttt 239880 tgctgattaa ctgaaacata attgtgcttt ttgaaaaaag agtgtgaagt tagttgattt 239940 ctgaaaaggt atgtaagaat gtaaacacga ggattcttaa tatcagtgga agaaaatgac 240000 tcagtggtgg gactgtgttt tcacactgct aataaagaca tacccaagac tgggtaattt 240060 atacaggaaa aaggtttaat ggactcagag ttccacgtgg ctggcaaggc ctcacaaaca 240120 tggtggaagg caaggaggac caagtcatgt tttacaagga tggcagcagg caaagacaga 240180 gcttgttcag ggaaactcgc cctttataaa accataagat cttgtgagac ttattcattg 240240 tcacaagaac agcacaggaa agacctgccc ccatgattca attacctccc agcaggtctc 240300 tcccaaaata tgtgggaatt caagataagt tttgggtgat gacacagcca aaccatatca 240360 gactgaaaac agagcagaga gatgttcatt ccatggaagc taaaaggtac atttgctctg 240420 agctgtgagc tcgcatacag aagtgggctg ctcagctact acagcccagg tcacactctg 240480 ctgtctcctg gctgtgtgac cttgggcacc ttctttaact cccatgcacc cgtttggtaa 240540 aacttggggc tggcctgggt tggaggccaa attcaaccac aagccagcca atgttagcca 240600 gctagaggat ttgtacttga caaatatttg tgtttgactg ttgacctggg caatgtttaa 240660 aaatttattt tgaatagttg ccaacactaa acattttaaa ggtaacataa aatctggatt 240720 tccagctcct ctggaagaat tataaatctg gcaatgcagg ctctcattcc cacctggcag 240780 ctccagcagt ggctttggtg ctcttcactc cagctcatca atgtccccat caccccctcg 240840 tggccccaac accaacactg agacagagta ccagctgcca attgtgtggc tgtctcttta 240900 ttataattca gaagcattaa atgatttatg atattcatat tcctatctaa agtagagtat 240960 ttgtttaaag aaaaatgaaa tataacattt ttatggaaat aagaatgtgc attggctggg 241020 cacagtggct cacatctgta atcccagcac tttgggaggc cagggtgggt ggttcgcctg 241080 agttcaggag tttgactcca gcctggccag catggtgaaa ccctgtctct actaaaaata 241140 caaaaattag ctgggcgtgg tggcacatgc ctgtaatccc agctactcgg gaggctgagg 241200 cagaagaata gcttgaacct gggaggtgga ggttgcagtg agctgagact gcaccactgc 241260 attccagcct gggcaataca gtgagactgt cttaaaaaaa aaaaaaaaaa aaaaaaaaaa 241320 aagaatgtgc attaagcaca tatataagtg aagaacatat tttttgttta aaacccattc 241380 acctttgctc atgtttacta atgtcttggc ccctgatggc ctttcattct gtagcctgta 241440 tagagcaggg atcagcaaaa tggggctcac aggccaaatg tggcccaacc cctttttttg 241500 taaatgaagc tgtattggga cgcagccatg ttcacttatt cgcattttgt ttatggctac 241560 tttcatatta caataggaca cttcaggagc tgcaatagag actctgtatc tctcaaagcc 241620 aaaaatattt atcatttggc ccttcgtaag aaaaagtttg ctgactttga ttttcagcga 241680 gggcacccag agagcttgga agtgattact cctgggctca taacatgaaa aaaagctgaa 241740 cagaatgaaa atctatgact tttctggatt catcagagga ttgaggtcac agggcaaacc 241800 actggtctgc aatctggaga gacaggtcaa cacagagaat gagagccaag gtcagcttac 241860 agggggcaga agcttgcgga gccagtgatt ggtaggaaca cgtaaatggt aagttcaatg 241920 aattgctgga gactaagtat gtgaggcttg agagttaata tttcctagga gcccctacag 241980 ctttcttgag tttttcctcc aggaagctca ccagattctc acatgaaggt cagagaaaaa 242040 tcccctccag ttctgagcat gggaagtgag aaggtaagta tttgaagcaa gcccattgca 242100 ttctctataa gaaaaccatg tccttcaagg aaggctacct taccagaaca ttgtccaact 242160 tgaggaaagg aaaattagcc actggtgccc ccttctatcc tgcctgcctc acataggagg 242220 aggaagaaaa gctaaaaaac aaacaaacaa ataaacacaa ccacaaagca catctgaaag 242280 tcacaatcca gggacttggg tatactgcaa gctgagattt tatcttaaga gtatggagag 242340 cttcctctcc ctaacacctc agcatcacat caacaaggct ccaaaataat accagtgaat 242400 tacagctaag agagctgcaa gatgcagcct ctattcaaga atgagttcct agggaaacac 242460 aaagacaaca agagagaaaa gtgagataaa gaaactaaag gctgtgtcac ctgcagctac 242520 atcaaacatt aaatacagcc cagattcatg taaaacctca tgctaaaagt ctaattatat 242580 tagctttcat tacccaaata ctgtgtctga ctctcaacaa ataatgacaa gaaatgaaag 242640 gcaagaaaaa atacatatga agagacagaa taagcatcag aaccagactc atatatggca 242700 gtgattttgg aattattgga tatggaattt aactatgatt aacagaatta gggttctaat 242760 aggaaaagta gatgacaagc aagaacagat ggataatgtc agcacagaaa tggaaactct 242820 aaggaagaat ttaaaggagg tgctagaact caaaagcaat gtagcagaaa taaaaagtgc 242880 ctttgatgag ctcattaata gactagatat aaacaagaaa gaatcaatga gcttgaagat 242940 acgtcaggag aaacttttta aaccaaaatg caaagagaaa aaaaatgaat ggaaaaatag 243000 aaacagactg ttcaagtact ctgggacaat tacaaaaggt ataacacatg cagaatgaga 243060 atcccagaaa aaggagaaaa gggagcagaa gatatatttg aaataacaat agctgacagc 243120 tttccaaaat taatgataga cactaaacca catatccaag aggctcagaa aaaaaaaaaa 243180 aaaaaaaaga aatgcaaaaa agtctacacc taggcatgtc atatccaaac tgcagaaatc 243240 taaagaaaaa gagacaatat tgaaacaagc cagagaaaaa caccttacct gtagagagac 243300 aaagctaaga attatactgg actttttgcc acaagctaca caagtaagag agtggagtga 243360 aatgtacagt attgaacaac aacaacagta acaacagcaa caaaaaaccc accaagatag 243420 aattctctgt ctacataatg tttcttcaaa agtgaaggag aaataaagat ttttgtcaga 243480 cacaaaaaaa ttgagggaat ttgttaccag taaacctgcc tttaacattt aagaaaggtt 243540 aaaagaatgt attcagaaag aagaaaatag catgggtcag aaattcagat ttacataaca 243600 aaaggaggag cttcgtagga ataaatgaca gtaaaataaa atgcataagc agaattagaa 243660 aaacttgctg ttatagttag gggcttcagc acccctctgt cagtagttaa cagagccagc 243720 agacagaaaa tcagtaaggt tatagttgac ctatgtaaca atgccatcaa acaactgaat 243780 ctaatttaca ttcatagaat acttcatgaa caacagcaga atgcacattc tttacaaatt 243840 cacatggtct attcaccaag actatattct ggactataaa agacatctca agaaaattaa 243900 aatcatagac atcatataaa atatggtctt gattataatg aaattaaact tcaatggaat 243960 taaatttaat aacataaaga cagctgcaaa tctctaaata tttggagaat aaaaatacac 244020 ttccaaataa cacataagtc aaagcagaaa tctcaaggga aatttaaatt atttgtaact 244080 aaatgaaaat ataacctatc aaaatgtggg atgcaatgaa atcactgctt cacagaaaac 244140 ttataacatt gaatgcatag attagaaaag aaaaaagatt tgaaatcaat agtcgaagct 244200 tccaccttag aaaactggag taagaagtgc aatatcagcc taaaacaagc agaagaaaga 244260 aaataataaa acttagacca gaaatcagct acattgagac caggaaacca gtagagaaaa 244320 tcagcaaaac taaaatctgg ttctttaaaa atgtcaataa aattggtaaa cctctaacct 244380 ggctatcaag caaaaagaag acatgaatta ttaatattgg aaataaaaga gaactcatca 244440 ggaatgcttt catagatgtt aaaaggataa taattaaagg gataataggg ttatgaaaag 244500 ccctgtagcc ataaatttga atacttggat gaaataaact aatttcttga aggacacaga 244560 ctatcaagat ttgtataagg agaaacagat attctgaatg ggcctatatc aatgaaagaa 244620 attgactcaa taattaataa ccttccaaaa aagatagcat caggcaccag tgtttgcact 244680 agtgaaatct accaactctt aaagaaaaaa aatgatacca attctttgca atctcttcct 244740 aaaaataaaa gctgagctga cgttatgtct catgactatg atctcagcac tttgagaagc 244800 cgcagcgggc ggattgcttg agctcaggat ttccagacca gcctgggcaa catgacaaac 244860 cctgtctcta caaaaaatac aaataattat ctgagcatgg aggcacatgg ctatagtccc 244920 agctacttgg gaggctgagg tgggagaatt acttcagcct gggagacaga ggttgtagtg 244980 agcagagatc tagccactgc actccagact aagtgacaga gtgagaccca atctcaaaaa 245040 aaaaaaaaaa aaaaaaaaaa gtagaagcag agggaacatt tgctaactca tttgatgagg 245100 ccagtattat cctaaaacca aaacagataa agacatcaca agaaaactac agatcaatag 245160 ctctaatgaa tttagataca aaattactca ataaaatact agcagattaa atccaacaat 245220 gtataaaaag aataatgtac catgatgcat ttggatttat tccaggtatt gaaggatgct 245280 ttaacattag aaaatgagga aatgtaacct atcgcattat aataggctga agaatgaaaa 245340 tcatatgatc ataacaacag atgcaaaaaa gaatttggta aaaccggcac ttatttatga 245400 taaaaatgtc tcagcaaact aggaatagag gggaacttcc tcatcttgga aaaaagaatc 245460 tacataaaac ctataacaga catcatactt aataatgaga aaataagttt cttccctcta 245520 agattggaac aagtaaaaga ttttcctttt catcactcct tttcaacatt gtgctggaag 245580 tctgagctaa tccaggaagg caagaaaagg aaataaaata tatacagatt gagaagaaat 245640 aaataaaatt gtccttgttc acagatgaca tggtagtcta tttgaaaatc tgaaacagtt 245700 aacaaaaaaa tttctggaat taataagtag tcatagaggg ttgcaggata caagactaat 245760 atatgaaagt caattgcttt ccaatgtacc agcaataaac aattggaatt tgaaatgaaa 245820 aaccaatata atttctatta gcaccaaaaa acccacttaa atattaatct aactacatct 245880 ggacagtatt tacatgaaga aaactacaaa actctaatga aatagacaag atatatagaa 245940 atggagagag attctattgt catggacagg actcaatttt gttacgatgt cagtttttct 246000 caacttgatt tatagattca gagtcatccc aatcaaaatc tcagcaagcc aatttttaca 246060 cattgaaaaa ctgattctaa agcttacatg gaaagctaaa agacctagaa taggcaagga 246120 gatactgtag aagaaccatg agagaactga cattacctga cttcaagact tttggtaatc 246180 actagcttct ggtgttggtg gaagaacagg caagtaggtc aatggaacag aatgagggct 246240 cagaaacaga tgcacacaaa tatattcaac tgaatattga caaaggaaca aagacaattc 246300 aatggggaaa ggatagtctt ttcaacaaat aatgctggaa cacctgaaaa tccatgtgtg 246360 aaagaaacta gacacaaaat ttagcaaata ttttacaata cgtgctttaa caacaacaac 246420 aaaaaaactc aaaattgatt agagacccac atataaagtg caaaacaata caactactaa 246480 aagataatat aggaggaagt ctaggtaacc ttgggtttgg ttttgacttt ttagatacaa 246540 ccgcaaaagt atgacgaatg aaaggacaaa ttaataagtt ggtgctatgg tctggatgta 246600 tgtgtctccc caaaattcat atgttgtgat agtcttagga ggtggggcct ttgagaggtg 246660 attaaatcat gaggtctctg ccctcgtgaa tgagattagt gcccatataa taaagacccc 246720 agagagctgc cttgtctctt ccaccatgtg aggacgtagc aagaatcacc atctatgaac 246780 cagaaagcag ctccacacaa gacagcaaat ctgctggtgc cctgatcttg gactatccag 246840 tctccagcac tgtgagaaat gtcagttgtt cataaattac ccagttgatg gtattttctt 246900 atagcaaccc aagctagcta agatagtttg acttccttca atttaaaaac ttctgctctt 246960 tttattgttg tatctctgcc aggttttggt atcaggagat gatggcctca taaaatgagt 247020 tagggaggag tccctccttt tcaattattt gaaatagttt cagaaggatg gtaccagctc 247080 ctctttgtaa ctctgtagaa ttcagctgtg aatccatctg attctgggct ttttttggtt 247140 ggtaggctat taatgactgc ctcaatttca gaacttgtta ttggtctatc cagagatttg 247200 acttcttcct ggtttcatct tgggagggtg tatgtgtcca ggaatttatc catttcttct 247260 agattttcta gtttatttgc atagaggtgt ttatagtatt ctctgatggt agtttgtatt 247320 tctgtggggt cagtggtgat atccccttta tcgtgtttta ttgtgtctat tcttctctct 247380 tttcttcttt actagtctat ctagcaatct atctattttg ttaacatttt caaaaaacca 247440 gctcctggat tcattgattt ttttgaagga ttttttgtgt ctctatctcc ttcagttcta 247500 ctctgatctt agttatttat tgttttctgc tagcttttgg atttgtttgc tcttgcttct 247560 ctagctcttt taattgtgat gttagggtgt cgatttgaga tctttctggc tttctgatgt 247620 gggcatttag tgctataaat ttccctctta acactgcttt agctgtgtcc cagaacaatg 247680 ataacacatg gacacaggga ggagaacaac acatactgag gccagccagg gggttggggg 247740 ccaagggagg gagagcatta ggataaatag ctaatgcatg tggggcttaa aacctagatg 247800 acaggttgat aggtacagca aaccaccatg gtacatgtac acctatgtaa caaacctgca 247860 tgttctgcac ttgtatccca gaacttaaag taaaataata ataataaaaa aaagccttct 247920 gctcagcaaa agacacaatt gaacaattga gaacgttaaa agacaagcca aagatggaga 247980 gaaaatcttt gtgaaacaca tattggaaaa agacttgtat ccaaatatat aaagcagcct 248040 taaagctcaa caatgtgaaa acaaatgatc caatgttaaa aaagaacaaa agatctggaa 248100 gatcacctca cctaagaaga cacagaagtg gaagataaag atatgaaaag atgatcagca 248160 ttatatgtcg ttaaataatt ttaaattaaa acaataacga gatactactc tatagctact 248220 aaactggcta aaattcaaaa aacttacaat atcaaatgct gatgagatgt ggagtaacag 248280 agacggcaga gtcactttaa aagacagttt gggccagtcg cggtggctca cgcctgtaat 248340 cccagcactt tgggaggccg aggtgggcag atcacaaggt caagagatca agtccatcct 248400 ggccaacatg atgacaacct gtctctacta aaaatacaaa aattagccgg gtgtcatggc 248460 gtgcacctgt aatcccagct acttgggagg ctgaggcagg agaatcactt gaacccagga 248520 ggcggaggtt tcagtgagcc aagatcgtgc cactgcactg tagcctgggt gacagagtga 248580 gactccatct caaaaaaaaa aaaaaaaaaa aaaaaacagt ttggcagttt cttacaaact 248640 aaacatagtc ttaccatagg atccagcaat cacgcttctt ggcattcatg caaataattt 248700 gaaaacttat ttccccgtaa aaatctgcac atgaatgttt actaaaggca accgaactaa 248760 aatcaaccga agtgttcttc agcaactgag tgagtgaact gtggactttt actcagtgat 248820 gagaagaatg atccatcaag ctacaaaaag atcaggaagc accttaaatg catacagcca 248880 cacaaggaaa gcaagtctga aaaagccaca tcgtatgtgg atccaaccat atgacattct 248940 ggaaaaggca aatgctgaga caataaaaat gtcagtgact gccagggatg tgaaggtggc 249000 aggtggggaa agatgaacag gacaaacccc agggatttgt gaggcagtaa aactattctg 249060 catggcacta gcatggtgaa tacatgacat tatacatttg tcagaaggca cagaacgtac 249120 aacacacaga gtacagctta atgtaaatcg cggcctttag ttaacagcaa attcctcaca 249180 ctgttgcaag atgttcataa tataggaagt tgagtatagg ggagtggcag gggacagtgc 249240 atgggagctc tctctactat cgcctcaatt tttctataca tctgtaactg ttctaagaaa 249300 taggccgggc actgtggctc acgcctgtaa tcccagcact ttgggagact gaggcggatg 249360 gatcacctga ggtcaggagt ttgagaccag cctgcctggt catcatggca aaaccctgtc 249420 tctattaaaa acacaaaaaa ttagctgggc gtggtggtgg gcacctgtag tcccagctac 249480 ttgggaggct gagggggaag aatagctaga acccaggagg tggaggctgc agtgagccga 249540 gatcatgtca ctgcattcca ggctgggagg cagagtaaaa ctctgtctcc aaaaaaaaaa 249600 aaaaaaaaaa aaagcctatt actgtaaaaa agataggtta aaaaaaaaaa aaaaaccggc 249660 ttgcaaactt tgatttagaa ccatgaacct ttttatccta aaactctgtg aaatacttag 249720 taccccattt ctgtcattaa accaacaaag gagacatttc gtttgaagaa gatattttcc 249780 caagaaataa aacataaata tgaaatacac aaggtcatgt aggaaaagta gattattttt 249840 ctttaccctg tgaatattgc tctcagggtg tagcagtgcc ctccagtcag gcaaaaatta 249900 gttgaagcta gtaatagcca acctggctta gaaataacgg ctaaatatat gcattatgtt 249960 gtgagtgctt actatttatt gagagtgtgt tttattagat ttgggtttct gaaaatgtga 250020 taaattaatt gggttggtaa aattaactag caaaaatatt tgtaaacagc tataatctta 250080 attacaaatg agtttataaa ctttcatttt ttcattttaa gggaaaagac aagtgtagaa 250140 gatgatgctg tttattttat ttttaatata acatcatgct gccttaccta ttatcttttg 250200 atgaattctg gaatactgag gaacatgagc atatatatat atatgaaata tttgtaaaat 250260 gaggaaactg ggagctattt tatttttccc caagagtgat tttcagctat aaaactgtaa 250320 tgtggtcagg tcgtagatca cataaaaatc attctatgtt tcccttaaaa ttatctaaat 250380 agagttcact agtttttctt aatgtgcaca tttcgtatca cccagtatgg tcaggggtgc 250440 aggaggtagg tcatcttcaa gacattttct tgttgcaaga aattaccaca attctgtgtt 250500 ctgttgttct tgtttttaag atatttacct gccaagcata cggcataatt atactttcca 250560 acctctccaa ttaagaaaga acttttggtt ctttgtgctg tggaactctg agtagataag 250620 atgttttttc ttttagctaa ctgaataata cccacaaaat tcaataagct ctttgacaaa 250680 aatggccatt gagggcctct gagtcacctt acgctcatca actcccaccc gtcaatgaat 250740 atcagaatat gggctctaat atgctttaaa attagtcctt ccttaaaaag gtgtcatgta 250800 ggggaagcac tcttatattt gaaagcaagt atcagaaagc tggagagtgg taccgatcct 250860 gcagatataa aaatatcttt agtgtttttc taaaacatct acttttctag gtagtacctg 250920 tctattatta ggggacaagt gagtcagccg tgttgatgtg acgatattag ggtccttctt 250980 gctacaagct catgtgccat tttaaggctt acccccagag catgggctca gcaaaccact 251040 gcagagaaaa caggctggtc ctagtgctct gccttgtgct agttcttgcg caaaggaaaa 251100 ccacaggcca gcagggccta agaatcagtc cagacacgca catgcactca cacagagcac 251160 agaggccaca gtttgccgcc tgtggatccc attaccaaca gggatgactt taggtaccag 251220 gatacttcgt ctcattcagg tcaaaacttt tactttgcct aaagcatttc tcattcgcga 251280 tgtttggatc caaagactgt agtaatgcta caacttgctt gcttctttgc tattttcctt 251340 tcttttaaaa atggattctc atcagaacat ccctttcaat gtaataaact atatttggat 251400 ctgatcctct tataaattgg aaccagagta tgtggttagg ttgtgcctca tcttttctgt 251460 tgataagtgt tttatgtgag gaggttcaga agagctgact ttcagctaca aaggttgtgt 251520 tcccgttcct gaggcaaaca gcaccctggc cttcagggca gagcttggct gggcctttaa 251580 gcactgggag tcttttgcac accttcgaat agagatggct cttggaaacc cagtatgtgc 251640 ctttccctag caatttctct tttcttttct tttttctctt ctctcccttc ccttctcttt 251700 tccttccttc cttcctcttt tcttttcttt ttttttgaga caggatctca ctttgtcacc 251760 caggctggag tgcagtggtg tgatcagggc tcactgcagc cttgatctcc tgggcgcaag 251820 tgatcctccc acctcagcct cctgagtagc tgggactgca ggtgtgcacc accatgcctg 251880 gctaattttt gtattttttg gagagacggg gtttcaccat gttgcctagg ctagtctcaa 251940 actcctgggc tcaagcaatt cacctacctc agcctcccaa actcatggaa ttataggcat 252000 ggatatggaa agaaatgcat agcagatggt aaaataagaa ggaaacacaa ttgcacttgg 252060 tggcaccaaa gaaggcctgc cctgtgctgc ctgggctagg gggacttcag aaggtgtcct 252120 atttgaaggt gcacccagta agtgttggtt gctcacctca cccaatacct acctgtcctt 252180 ccatcaggga gcacatagaa ttgggctcaa gagcatgaaa cattctcaag cgatatctct 252240 ttagcatatg gggttccctc tacaaagact gaggttactg tcttggcatc agcctcccct 252300 cccctgagta acaccaaaaa cacaatcatt tgttccattt gctggaccca gttgagagcc 252360 cacatctgtt actgtagaca gtcaagtttt tatctacata caagttattg attatctaca 252420 agttattgat tatgattatg gcatgcgacc ctctgttcac acctaactgt gctccagcat 252480 cctctttagg ccatcatccc aacattatct ctatggctac tctttattac cccctaccct 252540 gtgccaaata ttgtgctaac taatggcctg acagctgtta ttttattgaa tactcacagc 252600 agtcttgaga cagtcgttag tgtttttatt tttcagatga taagagtgag attcaaagaa 252660 tacaagtatc ttgcccaagg tcatattcct gaaacgacag gccaggatta ctgcccaagt 252720 gagtcctctt taaacccagg ttcctgtccg ctattgtgat aagctatgtc acactgtaaa 252780 attagtctgc tggttacctt ccagggactc atggctttgc agaatctcca cccaccagcc 252840 acacatgtcc agactctatt gcacagtgta ttattgttcc aaatctagga ttgattaata 252900 ttttcctgtt ttacctttaa gaggatgacc cttttttgac tttatcccaa taagttttga 252960 ggtaggggca tcttcctaca ggccttatgg atgaaaataa ttctccacaa ttttaagtat 253020 gatagccacc tgagattaac tgaaaagggg cttgtaagaa agcagaattt tgtttcaaat 253080 atagggggat aaatgaatgg acctaagtaa ctttctgaaa aagcataaac gaaaacaaca 253140 acaacaaaat atgctattta acctgtgttc ataggagtcg attaaaacct tctattttgg 253200 aacatgagat ttagcggaaa acatctgtag ataggtagca aatgttagca gctatttaag 253260 atgtaagtct gacttactga tgaacatcag aaatggatca ctcggtcgct tggaaattca 253320 acctccattt cctgtgtgta aagtaagctg aactggctca gactgagcat tctagctctg 253380 aatagtaaaa taacagtgag gaactcatga ccatgataca tgatgctttc agataatttt 253440 aaatagtttt ataatattga aacatcatag cctggtatag tggctcatgc ctgtagtccc 253500 agcactttgg gaggccaagg tgggtggatc acttgaggtc aggagctcaa gaccagcttg 253560 gccaactggt ttcaccagta aagatggtga aaccccatct ctactaaaaa tacaaagaaa 253620 actaaccagt tgtggtggag catgcctgta gacccagcta ctcgagaggc tgaggtggga 253680 gaatctcttg gacccaggag gcagaggttg cagtgagctg agatcatgcc actgcctgcc 253740 agcctgtgcg acagagcaag actccatctc aaaaacagag gaaaaaaaaa aaagagaaac 253800 atcatgaaaa ggtgaaggat tggaatgctg atagttgagg ctacaaaacc atgacataag 253860 tctaggagtt tggcctttat tccaaggacc aacaatttca agaattatta atagcacaga 253920 cttaataaaa aaaaattaaa aaatcctttt ttgtgaagtt ccaatatata aaacatatgc 253980 tttaactctt aaatagtgta gtttaagtta acaggtttct aaggcagtac cacacttcag 254040 tttagggcag aaaatacttt tagtactaat tttgaactct aatccagaaa ctattttggc 254100 tcttcaaaca tttaacttcg tcaaatgtat tttgttttgc atcttttaaa acctcgtttc 254160 catttaatca ctggtacaat atctgcaatt cattagctca acaaatatgt gcgtgcttgt 254220 gagttcttct gaactcttaa gggctgggga cagcaataag ttagaattcg atctgtgtct 254280 tcatggggct tatattctgt gagagggaag gacaataaac atataatcca tggtgataca 254340 agtgcggtga agaaaataac ccagagtgat gctgtagaga tgacatgggg tgagggtgat 254400 ggatgagatg gtcaggaagg gttctccaag gtctcccttg gcaagtgaca tctaagtcaa 254460 gacttgaatg tgaaggaaga agccagaagg aacagcatgg gcaagcacac agaggcaaga 254520 aagagtttgg tgtattggaa gaacaggaag aaggggtgtt tcggagtgga cagttaagga 254580 agtggtcagt gaagtgggag agacagggag gggtgaaacc actacacctt aaaaatgata 254640 gcgaggtctt tacattttat ttcaattgga gcaggaagcc attgtccaaa accaaataat 254700 aacttgacct tttgcttcct atttgagtct ctttaactta ttaaaaataa gacatacaag 254760 ctcatatgag tatgtgatat ttgatagata ttgagttaat atagtttatc agatatttca 254820 agtatttgaa gtatccttac tgttaccttg ccttaggata actacctaaa ctccttacag 254880 actaattgca ttatcagagt aatttctcac ctgaaaaatt taacatttta tatatgcaaa 254940 agtcagattg aaaaagaaaa caaaattgta cttagctcta aaactttaat ggggtattac 255000 tgccttcctg gatgttgtag accaccttct taaatgtgac acatttagca attctgaatg 255060 ccagcaggat gttgtagact accttcttaa atgtgacaca tttagcaatt ctgaatgcca 255120 gaaggcagct gggccatggg ggagagtcct ggctaaggtc aaagtaagac cctgtccctt 255180 tcttgctctt taattcttgg gcagataatg tagtttctat gacacataat tccttcattt 255240 gtaaaatggg tccaacaagc taatacatat tattggtaag ctattagaaa tcgaatgcat 255300 tttctccaaa tagcctgggc catttgtatt gccaacgtat acttggcata tggttaaggg 255360 attgaagtga aaaatattaa attagaattc agtttgtccc tattataact atgaccactt 255420 cttgggaaca accctagagt ttatgtatat ttataccttg ttacctcact ttgttctttc 255480 caaactcatt tttaatagaa ttattccaag aaatttaacc ctagtggaca ctttctattc 255540 cacacaatat aacataccct cacaagtaca ctccttttat ctgtttcaaa tgtctgtcat 255600 actgggatag aaaacaagtt aacatacaat tttcctcttt acttatatcg aatggtaagg 255660 aggcttttaa caaatggctt tatataacaa ctagtattgc gtgtttaggt aacaggtgga 255720 tactcagtac tttattggca atggtgatga gggaattttg atcttggaat tcccagcctc 255780 ctgaactatg aggaaaaata tttatgttgt ttataagtgt attattctgt ttccagactg 255840 ggtaattaat aaaggaaaaa gtcttaattg actcacagtt cttcatggct agggaagccc 255900 caggaaactt acaatcatga tggaaggcaa aggggaagta aggcaccttc ttcacaaggt 255960 ggcaggaagg agattgaatg caggaagttc taccaaacac ctaaaaaaaa tgtgatctcg 256020 tgagaactcc ttcactatca cgagaacagc atggggcaac tgcccccatg attccattat 256080 ctccacctgg tctctccctt gacacatggg gattatgggg ataatgggga ttacaattca 256140 agatgagatt ttgggtgggg acacggccaa accatatcaa taagccatgg cattttgtta 256200 tagcagcctg gacaaactaa ggcagttggt tagaatacat gtttttaagg caaagatgag 256260 gaaagggaag aatcctggac ctcaccatga taaccagatg gtttagacag ggcaataccc 256320 ctctaagatg ctgcttcacc tgagaaatga ggaggataat attggtacag gactttcaga 256380 agtgagataa tgttcaaaag ttacaaaagg gagacccaag tatagtctct tgttagtttc 256440 ttagtatttt tgactttgag atttattttt taaagtaata gtaagtgaca ttattattgc 256500 tattactagc tatatcatct attggctggt tactgtcacc agcactatac aaaatccttt 256560 aaatatgtta cctcatttac tcctcacagt gacaccatta agtcagagct gtttccccac 256620 attttacatg aggaatctga agtcagagag tttaatcaac tttccccatg ttcacactgg 256680 gagcagagtg gtggagatgg gatttaattc cagctgtaaa tgcatggggc agaacccctg 256740 caggggctcc atggctcatt aatgtgcccc tctggcccaa gcatgggtta agaaagtgga 256800 cctaatgata gagcactaaa taggggatat tcgaatcttg catttatcaa agtgccattg 256860 tccatatcat gttaatattt tatatttaca tacttccatg taagtcgcag acctgggata 256920 tgaatctagg cctttgagcc taggcttggt cttccctgtg ggtaaaaatc ctgttgcact 256980 ttgggtctat ttcttagtta cattggagat tcatattcag tgtttggaat ttcttacaaa 257040 atgacggaaa ctgcctacta attcccattg attgaagaca caatatctac caattcagtt 257100 ctcaggaaga ggagttatta ggtttaaatt tatttttaca tcttaaaaga aactgctgag 257160 tgataggaga ggagagtgtt aacttggagt gacagattaa aaaaagtgag ccagttcatt 257220 tgtacataat ttttggctat gttatccaga cataagctac cagaggacaa agcagtgtaa 257280 taaatctaat attctcaaat agtttgtgtg cagaagttta gcagtgagga tggttttgta 257340 atgaccgcac atgctagatt gcaaactcca ttcttcacta ttcatgtaca tttgatgtca 257400 tatacattgc caaagatgat ttcaaaaatg ccaagcttct agtctcactt tccttagtta 257460 tgatacctta tatcttaaaa gggtggtaat ttattagttg gttttttgtt ttttgtgtgt 257520 ttttttcttt tctttttgga gatggagtct tgctttgttg cccaggctgg agtgcagtgg 257580 tgtgatctcg gctcactgca acctccacct cctgggttca agcaattctc ctgcttcagc 257640 ctcccaagta gctgggatta caggcacatg ccaccacacc cagctaatgt ttgtattttt 257700 agtagggacg gggtttcacc atattggcca ggctggtctc aaattcctaa cctcgtgatc 257760 cacccacctc ggcctcccaa agtgccggga ttacaggcat gagccactgt gcccgaacta 257820 atttattagt ttttattatt tcattttgtt tagatagaaa gcatggagtt aaacattaat 257880 tgtactgtat tggctgccaa agcatagaaa ttgtattttg gaggtgagag ctgcagggtg 257940 ggttgctgtt tcttcactga ttattcccca tgagaaaaaa gtgacttgtt gattgcaatt 258000 tcgttgtgaa taatagttat tttcatggtc tttggaaaac aagacagaga agtggagagg 258060 gatatggtag cacggctggg attgtcacag gaaataactt gccccagtct actttttttc 258120 atacacatac agtttgagtt cctaattaat cagttgaaaa atccagctcc tgaaaatatg 258180 gctacagaat actgatcatt gattgtgatt cattttgctt cacataaatg gttgcatttt 258240 cttttcaatg agaataaagt ttttcttttt cttcctctgt caacataatt ccctttgttc 258300 ttattcagtt ttcttgttaa atgtttttcc acatgtagaa ttttacaaat tgaataatac 258360 atgcagaaaa aaagaaaaac aacaacctgt ctttttttct ttcgtctagg tcatgggaga 258420 atgaaaaact agaatcttca tgagcattcc atactaaata tttgtattag attatcatta 258480 tttattactt tgctaaacaa ccatttttat ccatcacttt ttatgaatct atagtaaaac 258540 aaaagtaaac agcctccatg ctttcaacaa ggagagtctg ttgctctaaa aatgtccatt 258600 tcaccacagt ttttcctcat caccacttgc tgaaacttac tgcatttgtt catgtttatt 258660 ataaagactt ttgccatcct gctcggtatt taagattcat cacaagggta ttcccccttt 258720 agatgttctg actaatgttg atattaacca tgtgacattc acaaagtaat tttttcctga 258780 atatatgaca gtatatatta ggttggtgca aaagtaattg tgatgtttgc cattaccttt 258840 taatgccaaa atccatgatt ttgagccaac ctaatatcag aggggtaggt aatgcaattg 258900 taagtgagtg ttctttggag tcaggtagat cctgcctctt ctcagagcag ctgaggggcc 258960 cgccaaggtc tgtggctgta atcctgagtc atgtggatca ggaacgcctt taagtccatg 259020 cctggcagct gaaggcatct gcagtttaga ttctccttgt accaattttg caaatctctg 259080 caatattgga agccatgcac ccagctgaat ggaagcaggt gaaaacaagg ccgcatgaag 259140 tcatagcact gtgggcagca gtgcaccagt agtagctctt tgtgctcaag aatcaaatga 259200 tgactgttgg cagggattaa aactggggct gactgagtgc tgggctttga tcttgccaaa 259260 tccactgaga cagctgaaat ttcatgaaaa ggtgacaagg atttcctaaa ccaaatgcaa 259320 attgatgttt aactttcaac tccagctcac acccaaaggc tttgcaagtg cttgaaaaaa 259380 gaatatctgg cttgtacatc agaaaatgac ctttacaata tattttattt gggctaaaac 259440 ttgtgctgca gcatcactga aaaaaattac tcttactatt taaatgatta tacttttcat 259500 aaaatttcaa tgacagagat gctaagtaga gatgatgttt attgaaaggc attcttaaaa 259560 tttgagaagg atttatcaaa tgataaacaa cattttgtga taaagactat gcattcccac 259620 ttatttggta atgcagccag ttacggggta cacaccattt ttttctttaa ctgatgtgat 259680 aaaaaattgt ataaaactta ataaacattt tccaacatga atggatgctg taattaacct 259740 atactcacta aaatcagtgt gtggattagc attgtattgg gaaaaatatg tgattatgtg 259800 agttataacc cagattttgt catgaaaatt agatgcttaa agctaagaca tgaccctagt 259860 gttctcatca gaaatacggg tagatacaaa ttagatgatt ttgaggtaat tttcagttaa 259920 aagtctctga tacatatcct ttttcatatc ctctccaatg gacccttgtt tcattgatga 259980 gattattaca cgtattaatt cgctcccaaa gccttttttg tatgtttgtt gatcacaaga 260040 ttattttaag tataataatt ttactagatt taaaaattat ttttgaaaag gttgtgtcct 260100 ctaatgtact ccttgaatta ctcatctgct cttctttatt tttgtatctg gaattagtgc 260160 cttgttttcc tttttagatg ctgtgtgatg tggttactgc cccaaatgtt catatttgct 260220 accacttaga gtccagcctt cttctgttgt ctaattatat gctattaaga ctgtcatatt 260280 gtgttgttag gtacagaaat ttgctttaga aacaaactga ggattgcgta agtattgaca 260340 tggcagggta gtgttccatg tgtttcttgg gcaagttggg tttcaagcat ggatctttgt 260400 ccacacctct cgcaccttct tggaaatata tacagcaatg tcaccagaaa tatcttgcac 260460 cttaaggctg tctgtcactg tcagcatcac ttggaagctg gtcaggaatg caaaatctca 260520 ggctctaccc agatctcctg aatcggaatt gaactttaac aaatcctcta gtgattatta 260580 tgcaaatgaa gtttgaggag cgctgggctg aaacatcctt ctccttcata acagctttgg 260640 gtggggtgct tctgaacact ctttcccaag atgcagtgtt gtcattttcc ttaatcaact 260700 ctgtctctgg gacacagaac agtcaaacaa gattttctgt gttagtctgc ttttatgttg 260760 ctgtaaagga ttacgtgaga ctgggtaatt tataaagaaa taggttcatt tggcttatgg 260820 ttctgcaggt tgtacaagaa gcatggtgcc agcatctgct tttggtgtgg gcttcaggct 260880 gcttctgttc acagtggaag gcaaagggga gccactgcac agagatccca tggcaagaac 260940 agaaacaaaa gagcacggac caggcatgtt ggctcatgtc tataatccca gcagtttggg 261000 aggctgaggt ggatggatca tttgaggtca ggagtttgag accagcctgt ccaacatggt 261060 gaaaccctgt ctctactaaa aatacaaaaa ttagctgggt gtggtggtgg gcacctgtaa 261120 tcccagctac gcaggagact gaggcaggcg aatcgcttga acttgcgagg cagaggttgc 261180 agtgagctga gatagtgcca ttgcactcca gcctgagtga caagagtgaa attccatctc 261240 aaaaacaaaa acaaacaaaa tgagcacagg gaaggtgcca ggctcttttt aacaaccaac 261300 tctcaggggc actctcatgg gaactagtag ataaataatt cattctttac tgcaaaaaca 261360 ccaccaagcc attcatgagg gatccactcc catgaccaaa acacctctca ctaggcccca 261420 cctccaacac tgggaatcaa atttcgacct acaacttggt gaggccaaac tatatccaaa 261480 ccgtaacacc ctcttatttg gtcagtcact actgctgaga ggtgggtgga ataattcttc 261540 attcagcatt aaacaagaaa aaatagatcc tctctgaaat tgcccatgta ttttgctgtg 261600 ctttaaaaaa gacttgtaga tctattacca cttgtaaact tttgcatatg tgttctttta 261660 agcatttttc tttttttttt tttttttttt ttttgagacg gagtcttgct ctgtcgccca 261720 ggctggagtg cagtggcggg atctcggctc actgcaagct ccgcctcccg ggttcacgca 261780 gcatttttct ttaacactca atagagtatc ttcatggatc taatgagctc caatatttcc 261840 catctctcca accctttttg tgcttgtgtt agtccatttt acattgctgt aaagaaatac 261900 ctgacactgg gtaagttgta aaaaaaaaaa aaaagaagtt gatttgtctc gcggttctac 261960 aggctgcaca agaagcattg ccccagcatc tgcttggctt ctggtgagcc ctcaggaagc 262020 ttctacttgt ggtgaaaggc aaggtgacat ggcctcccac atgacaagag aggaagcaag 262080 agcgagagga gggtggtgcc aggctctttt taacaaccag ctcttgggag cactctctct 262140 ggaattaata gagctgaaac tcactcatta ccgtgaagac ggcaccaagc catttataag 262200 gatccacgct tatgacccaa acacctccca ctgggcccca ctttcaacac tgagggtcac 262260 acttcaacat gagatttgga gaggacagac atccaaactg tatcagtgtt cttgtatctg 262320 tggagcatca gaatcaccaa gatggatttt tgacaatttc aggttcatag ctcccaccta 262380 cagcgcttcc tggaccgaga gaaccccctc cgcaggacct ggtaactgtg cagagctctt 262440 cagggcttcc agggagctgc catgtttggg ccctgctgac ctgactttgc agagtccctg 262500 ctgcttcttt gagggaggga ggtgtgatga gaacagtgat gttgatgaat gtaaaagcac 262560 ttcgcagact gcagctctcc gcacatcgcc atgggcaccc tctgctttca ttcttccatt 262620 ctgcgattct tcctgatttc tatgcttttt ctagcacctc actgccctgc tgccgacgct 262680 tctgagatga aagttgatct caatccttgt cattctgata acactccagc ttcacatctt 262740 gagataattc caaggttcct tttatctgac ttgcagatgg atttgcaaaa tatatgtaat 262800 tcatttatca cctaggcttg acctggttac ttctaccatg aggtaactag ggctctgaaa 262860 ctggagttac tggtgcttca ggtgagctat gcctgtgccc ctgtgtaaca ccaaggagcg 262920 gaacctgacc ccaacaggca agttcatggg aggaatatca gcttctctgt gcttcttttc 262980 ttatggattt ttccatggca catatgggaa gtggggatca aatgaggtct tttctgactg 263040 atacagaatt gttttcccct acaggttttt gggggcatag ttccaagcac actggcaatt 263100 ttgcctcatt ccttaatgca gaggtatcat gcttttcaaa atacagaaaa acgccactga 263160 attttactca ctttgatcct ttactatctg ggcttttttt tttttttaat agactttatt 263220 ttttaaagta ggtttcattt cacagcaaaa ccgagtggaa ggtacagagg tttcctgtac 263280 acccctgatc ccacacatgc acagcctccc ttgttatcag catcccccgc aagagtggta 263340 catttgttat caatgaacct gccttgaaag atcattatta cccagtggac atagtgtata 263400 ttaaggttca ctctgggtgt ttattagttt ccttgaatat ttgaaagact caaggaattt 263460 ccttctgaac cagttttcca gccaaaagga aactggcatt ttttaaaaac taggacattt 263520 tctctccctt tatcctcttc tcttttttcc ttcccactcc cctggtaggt ctgaggtccc 263580 ttaaagttga ggtgagggtg ggaagagaca ggtggggaca gcagagtcag gtgtggtgga 263640 agaagggagg gcagaggacc agctcgtgtt ccatgtacca ggccgagaag catattcgtg 263700 tctgtgggtt cgtttgtggg ttatagttcc gaaagttgat ataccacaaa tacaactctc 263760 tggaaattga acagccagat acgaaatcaa tggaaatcaa acccagtctg gaattgttaa 263820 tataatctgt cctcaaccca gaaaaagcag tgagtgcttc agatggtaca atgtgtactg 263880 gcccctggta acctttgcgt tgctggctgt gcccaggatg tttatttctt ttgccttaca 263940 tttataaaat ggatctcttg gaaacttcag tactggtttt ctaaacatcc ttttgtgatt 264000 ctactttgta cttgcctgaa ttctgaagtg atctttcttc aatagttcat tcatagtcag 264060 tcatccttga tctatatata tttttttact gattcctaaa attttttggt aagtttaatt 264120 catctctcat ctagtaatga ctttaatagt ctgttgcaaa tatcggattg cttttccatt 264180 gctcaaatat cagtgtgcag tacatataaa ggcaattcct ttgtttacca aaggacagtt 264240 cccactaggt taaatctatt gctccatctg gcccagggga tgggttctgt tcacttagtg 264300 tttccaaata tagggcactg tgttctagac actcttgctt ctagtaaggc aatgttcaaa 264360 atatcatctc aacttctagt aagtacttat tagtaaaacg cagatgctct ctaaccagag 264420 ctcattttct ccaggtctta tctttatgta catagtatat gtacagaatc ccagtgactg 264480 caaattcctg gaatatgtat tatgtgtgtt tatgtctcta atttgctatc tctccttgta 264540 tgcttaatgt tgaactttaa aaccactttt tgggaattgt tacaaaagct atgtttacta 264600 catactatgt gtatatattt ataatacata acctaagaat gtgttgctct tgatcctttc 264660 ggctgggact gttagttatc ttggtctctg aatctggttt ctgtgtatgt gagtatgtgt 264720 ttatttgtat attttgtccc atttttggac tcacagaaaa ttaaaaacct gcaaaccgaa 264780 actcaccgtg aaaatatttg atataggtgt ttttggatgc attttaaaaa taataagtat 264840 tctcattatt taaacactat tgtaacactt cagcaagatg cagatttagg cctgaaatca 264900 accactggaa tatatgaaga agaactgatt tatggatgtt actttataga gttttattat 264960 acacagtccc caggactata tagccaatcc cagtagggct taatcaggta ccgttaaata 265020 ctgggcttta ggaccataat cctaaactgc agaatgacat ttatctaaag taattacctt 265080 gtgactcaac cacatttcac tagtatttgc taatctccct agcatatggg atctgggaat 265140 taaaaataag cagatcaaat aaattacatt ttatggtatc cttagaggat acaatttgac 265200 tttggaattg aaaatatgtt tgattgcgtt actttgttaa ttttttttac aaggaaaaat 265260 taaaagaaag aaattcttct atatgaaaat gttactgtat agctttaaag gcagtaagaa 265320 taaactcgta gccatgaatt accaaactca atgccttttt gtctgtttcc agctaacacc 265380 tgtgtcccct ggaaggcttg ggtagcaaat gtgcccacct aacagtggga aaaatagctt 265440 ctgctgggct ggcaaaagca gaaagtcgta ttttggaaag agtgaagaaa aatgtcaatg 265500 ctgacctcac actttctccc agtttctgtc cccatcccca ctcccctcct ctcacacctg 265560 ggaggaagtg agaaagttgc tacagtttag gattatgaac tttggaataa gacaaacctg 265620 ggtttgaaac ctggcttgcc cactaactgg ctaagcaaac ctggctctgc tgtttgacat 265680 tcctgagccc ctatttcttc gcctgtaaaa cagggatgag agtgtatacc tcaccagttt 265740 cagagataag atttataaaa ggtcctaggt gaacacttct ggctcagaga ttgacacaaa 265800 gtgccataaa cagctgctca gcccatggaa ctagcaaaag gtggtctcag tcctgagggt 265860 ggggactaaa actaggtttc ccgccacctc cttgaggctg cagcgcattc cccagcttct 265920 gccagaggac cacatatgct tcttcgttta aaggattctc ttacgattta aaaggacctg 265980 ctttatccag agtcctgtct tctttttcat tcccattgat catttgtgtt ttgctgagat 266040 gtttttctat actatattat tcgtcttttt aaaaacaaaa cacagctttc attttcaatt 266100 ccttgttgtt ttgtatttta tcatctttct tcgaagtcct ttcagtttac tgcattcttc 266160 tcgcttctta aattgaatat tgagctaatt tgtttccagt ctttcttttt caaaaaagaa 266220 atgcatttaa acctatacac ttctttctaa taaacaccat agctatgctc cacaagatac 266280 ttttcaaaat ctgttattgt ttttctttag ttagtcatgt aggtacatat atttttcctt 266340 tggcttctgg tacattgggt gttttccact tactgcattt ggtcttggat tgtcttccag 266400 cccacccgcc tttcctgtcc ccattagatg attctctatt tcctttattt cttctactgg 266460 tgtggaagtt tatataagtt ctattgattt ttttctactt tccatgctct tttaattaca 266520 attttaaaat ctaccttctt tttaacgttc tcagtagtct gttttgtttt tttttgagac 266580 agagtctccc tctgtcaccc aagctatagc tgtagtgcag tggcaccatc ttggcacact 266640 gcaacctctg cctcttgagt tcaagcaatt cccctgcctc agcctcccaa gtagctggga 266700 ttatgggcgc ccgccaccac gcctggctaa tttttgtatt tttagtagag acggggtttc 266760 accatgttgg ccaggctggt cttcaactca tgacctcagg tgatccaccc acctcggcct 266820 cccaaagtgc tgggactaca gacgtgagcc accccgacca ggcctcagta gtctttaaaa 266880 gttaatttaa tgtagtccca gctactcgag aggctgaggc aggagaatgg cttgaactcg 266940 ggaggcagag cttgcagtga gccgagatcg cgccactgca ctccagcttg ggcaacagag 267000 cgagactctg tctcaggaaa aaaaaaaaaa aaattaaaca tggtaaagtt ggattctcca 267060 aggtagatct agaatctgtt attcaccatt ggttctggtg gatgatctga agtgaagatc 267120 cgtgtagcac ggaccctagc caatcaggag agaggcctga ccatcagctg agtaccctgg 267180 gccaccacgt ggctcacaat ggctgaatgc ccaccttcta cgtgacatcc cacatgtgag 267240 tgtgacaccc tcttagtacc aaagaaaaat cttcactttt ttttgtggtg aaggtctgat 267300 agtagtacat tcttttattc ttatatctga aaacatcttt gttttgctta atttttgact 267360 aataacataa atggagatgg aatcctatat tgacatttat tttccttcag aatttttgta 267420 atgattttct agcgacgatc ttaactttgt cagtaatctt tttctctctg ataggttgga 267480 atatatttct ctggctctgt aatagtctgt agtttcatat aggcaagaca tgggtttctt 267540 tcctgcttgg cttgtaatct ttctagaatc caaggattct ggctgtttgt cagttctaga 267600 atctccttca gattttagct cttcaaatat tgtctcttct ttcgtcttct tccaggtctc 267660 ctattaaaga gacattggaa tttatcattc ttttctctat atctcctaac ttttctttca 267720 tattgcctac ctctacccct ctgtgttatg ctttgggtga tttcatcaaa tcagcttttt 267780 ttcctcactg cttctttttc ttctgtgtct actctgaagt tttattgagg tttttttttg 267840 gatctgcttt cagaatccaa attaatttat tataatttaa ttatgtacct ctgaacttca 267900 tatgtattgt tgctttcaga tgatccaaaa aaacacagac ccatcaggtc ttttgcttgc 267960 tttctgtggt gggctgtggt ctgtgtgaga attgttcccc tttggttatg ttgatttcct 268020 ttgatcccta tagcccattc cctctacctc cctctgtcgt tacaaatgtg ctaatgtgca 268080 tctttctgtg ttttgcacaa tgcatattgt tgttttgttt gcatgtgggt ttcaatttac 268140 atcatcaagt tgtattatac atctttcatc ttcatccaca ctatgtttct ggaactcttc 268200 catgtcactt gaaaattaaa ttcctgacac ctaactgctg cactgtactc tatggtctct 268260 atactgcaca ttttatgtat ccccattccc agggatggat tctaaaactg accaacaacc 268320 ccatcataca tcttgctgtg tccataattt attccttcct atgggttctt gttctcgctg 268380 acttcaggag tgaagccgca gaccctcaca gtgagtgtta cagctcataa aggtagtgtg 268440 gacccaaaaa gtgagtggca gcaagattta ttgtgaagag caaaagaaca aaggtaccac 268500 agtgcaaaag gggtcccacg ctgggtgctg ctgctggctc cagtggccag cttttattct 268560 cttatttggc cctgcccaca tcctgctgat tggtccattt tacagagcac tgattggtcc 268620 attttacaga gtgctgattg gtccgtttta cagagtgctg attggtctgt tttacagagt 268680 gctgattggt gcgtttttac agagtgctga ctggtgcatt tacaatcctt tagctagaca 268740 cagagcgctg attggtgcat ttacaatcct ttagctagat gcaaaagttc tccaagtccc 268800 caccctaccc agaagcccaa ctgacttcac ctcctattgc tacagtgaac atccttgaac 268860 ttgtcccttt ctgaaggtgt gtaagagtgt ctctgggcta ttcacagaag ggtttaacta 268920 gatactgccg gatacctcta ggctgtgacg gtgttagcct gcactctatt tttctcagtg 268980 catgagggtt cttctgttcc tatatactca ccaatccttg caaatacctg gttttctaat 269040 gtaatgccca actttgtttt tactaactct gtttttaggc ttgtttccac ctgaattgat 269100 tctcccttag ctaagagagc cagatagact ccatcttggc tctttgactg gcagcccctt 269160 cctcaaggac ttaacttgtg caagctgact cccagcacat ccaagaatgc aattaactga 269220 taagatactg tggcgagctg tatccgcagt tcccaggatt tcgtctgatt gataacgccc 269280 aaagccccga gtctatcacc ttgtagtagt cttaaagccc ttgcacctgg aactgtttac 269340 tttcctgtaa tcatttatcc ttttaacttt ttgcctactt aacttctgta aaattgttct 269400 aactagaccc ccctcccctt tctaaaccaa agtataaaag aaaatctacc cccttcttca 269460 gggccgagag aattttgagc gttagccgtc tctcgtcgcc ggctaataaa ggactcttaa 269520 ttcatcccaa agtgtggcgt tttctctgac ttgcctggat acaacataat ggaggcccca 269580 gcaagatatt aacgccactg ggcgagagcc agtctcgctc cgggctcccc cggaaggaca 269640 gccggctcgg aggggggcgc cacctgagga aacaattttc aggtccccaa agagtgaccg 269700 tcttccggag gagagcggat cgactaccgt gtcagtgccc taaaattcaa catctgagtc 269760 ctcagcttct caccccgggg tcaggtaggt cagatttgac tttgttctgg ttctggtaag 269820 agggaagcgg cctggtcgcc ggctaataaa ggactctttt tttttttttt ttaataaagc 269880 ttttgagtaa ataattttat attttcaaat ttctccataa taagggatgg tgaatgaata 269940 tataatacat aaataaatga atattcattt atatatcatt acatatattt tgttcataat 270000 atatgaatga atggatgaat taatttataa atttatgata tataaattca catagaattt 270060 tcactaagat accctctcgt gccctttcca atttgcatct tatttttttt tttattttat 270120 tgttattata cttttagggt acatgtgcat gacgtgcatg tttgttacat atgtatactc 270180 gtctcaaagt gtggcgtttt ctctaactcg cctgggtgca acgctaattg ttgatagatg 270240 caaaggtata aaaagatatt tcgtgatctt agcccttttt atgattatta gttaattcta 270300 ggagttttga aataatttat ttgaacctta cgtaaaaatt gcgcatttat atcttttcat 270360 tgtgctccta tggggcttcc tgtcttcttc tgttggattt ttcaggagtt ctatatatat 270420 attataagta ttaaattttg ttgattttag atgttgcagg tgtcttctcc cattctgcca 270480 ctatcttaac ttgtctctgt tctcctgtgt taaacagaaa ctcatggttt ctcttaaatg 270540 attttttgaa ttataattta tatacaataa aaggcactga tcatttttta gcttaatatg 270600 ttttgtcatt ggaagacacc caagttgaca ccacctaaaa caagatgtag aacattcagt 270660 taactgtccc caaagaagat tcccttgctc ccataattat cagtgtccca gcctgcaccc 270720 aacccagatg caatcctttc tgatttgaac acaaattagt tttacctgtt atgtaaatag 270780 aagcaagtgg tatgtattct taggtatctg atttcttctt ttaaattata atacttctga 270840 aattcacaca tgttgttgct gatttcagaa ctttgtttct tttctaaaca tttttcctat 270900 tctgttgcca gacttttggg ctgtttccag ggattgacta ataggagaaa ggctggtatg 270960 aatatttttg tagaagcctt tttgtgaaca tatgttagga tttctcttgg ggaaatacta 271020 agtgggatgg catgtttaac tttataaaac ttctaaaagg taccacttaa actcttgcca 271080 gaaatgtatg atagttcttg ttgctccata ttctctccaa cttttcatcc caacagtatt 271140 ttaaatttta accaatatag tgtgtatgag atggtattgt attattgttt aaatttgtct 271200 ttatctaatt actaatgatg ctgttacatg tgctcattgg acgtgatatg tcttcttctg 271260 ggaagtgaca attcaggtca tttgcctaat ttttcttggg ttgccttctt actactgagt 271320 tgcaagagtt ttttttttta atatattttg ggtatgaatc ttttgtcaag tataatattt 271380 tgtttttaat ttgtagcctg cctacctatt tattagtgat gcctttcaat tagcaaattt 271440 aaaaaattga tgaagcctaa ttcttttatt tttctctagt taattttaac ataaggagtt 271500 gagtcggact caaggtttat ttccctccat ctatttatct gattcttaca atattattta 271560 tgaaacaggc tttcatcccc tgtcacctaa ttggctttgc accttgattt ttaaaaagag 271620 ccgtatatgt gtagatctct attctattcc cgtaatctaa ttgtctgtct tatgccaaaa 271680 ctacactgtc ttaattatat atgtttcatt cgcgtccgtg tgaagagatc accaaacagg 271740 ctttgtgtga gcaataaagc tttttaatca cctgggtgca ggtgggctga gtccaaaaag 271800 agtcagcgaa cagagatggg gtgggactgt tttataagat ttgggtaggt aaaggaaaat 271860 tacagtcaaa ggggggttgt tctctggagg gccggagtgg gggtcacagg gtgctcagtg 271920 ggggagcttt ttgagccagg atgagccagg agaaggaatt tcacaaggta atgtcatcag 271980 ttaaggcaag gactggccat tttcacttct tttgtggtgg aatgtcatca gttaaggcag 272040 gaacaggcca ttttcacttt tgtgattctt cagtaacttc aggacatctg agtgtgtatg 272100 tgaaggtcac aggggatgcg atggcttagc ttgggctcag aggcctgaca atatggttgt 272160 tctagaaatc aaattgtata attgttttga gatggtagtg attactaatg ttttattgca 272220 gtcttaaaaa tcaggtacct tagccaggtg caggggcggg cacctgtaat cccagctact 272280 tgggaggctg aggcaggaga atcccttgaa cccaggaagt ggaggttgca gtgagccaag 272340 accctgccat tgcacccagc ctaggcgaca gagcaagtct ccgtctcaaa aaaaaaaaaa 272400 aaaaaaatca ggcaccttat gtgattctct tttttgacat tgtttggctt ttgaaatgta 272460 ttatcttgcc ctactgcact acctaagact tcttgaacaa tgttgaatat tgattagaag 272520 tgactaaaag tgatgagtga atacctttgc cttgttccta accctaaggg gaatgtttcc 272580 aataattcag tgttagatat catgttattt gtatatcttc tgtaaatgcc ctttatcaga 272640 ttgtgaaagt tctcttttat tcttagtttt ttgagtattt ctcataaaag aagctgaatg 272700 ttgtcaaatg ctttttctac atgtattgag atagttatat aatttttctt ctttaatctg 272760 ttaatgaaat gaattatttt gactgatttt taatgttaag ccaattttgt attagaaaat 272820 aaacttgaca tggtcatgac ctgttattct ttttaagttt atagcatcca attgctaata 272880 ttttaataga tctttgtgta ttggaccata agggatattt ttcttttttc ttaaacttat 272940 aatgtttttt gtaggtttaa tatctgggtc gtgcagtctc agaaagtcat ttgggaagtg 273000 ttccctcctc ctctattaaa aaaaaaattg tgaaggattg gtaattggta ttacgccttc 273060 cttagatatt gacatctagt caggagtttt ttcttttatg tttttgtttt attttatggg 273120 aaggcttctg attacaaatt ccatttctgt aacaggtatt aggctattta gatgttctat 273180 tttttcttgc atcagttgtg ataagatgcg tttttaaagg aatctgtttt atataagtgg 273240 ctgtatcttt aatggcataa agttgtttat gatattccct tatttttaat atctgtagaa 273300 cctggagaga tgctactact tttattactg atatagattc ttttcatttt ttcttgacaa 273360 tttttctaga agtataccaa ttttattaaa ctgtcttaaa caaatttctc acattgttaa 273420 ttttctttta tgtgttttca ttttatttct gctgttttta ttatttcctt tcttatattt 273480 tagttgtttt tcttagctta ttaaaagcta aaactttttg ttttacaact tattattttc 273540 aattcaaata gggaattaaa gctatgaatc tccctctatg caccaccttc actgcctttc 273600 acattttgat atgttgtgtt ttcattttca ttcaattcaa aatatatttt atttttccct 273660 gtggtttttc tataggtcat catctgttta gaaacatgtt gtttaatttt caaatatttg 273720 agtagtttta aagctattta ttttcattta tttcaagttt atttatttat ttatttgaga 273780 cagagtcttg ctctgtcgcc caggctggag tgcagtggcg ccatctcagc tcactgcaag 273840 ctccacctcc cgggttcacg ccattctcct gcctcagcct cctgagtagc tgggactaca 273900 gtcacccgcc accgcgcccg gctaattttt ttgtattttt agtagagacg gggtttcaat 273960 gtgttagcca ggatggtctc gatctcctga cctcatgatc tgcccgcctc ggcctctcaa 274020 agtgctggga tcgattttaa tattattgtt ttcagctatc atactttata tgaattttat 274080 cattatgatt tgctggggaa tttttcatgt tgcagaatgt gattcatctt agcaagtgtt 274140 tcatgtgatc ttctcaagaa attgtagtgt atagttgttg agtggagtat tctattagag 274200 ataattatgt aaattttgtt gacagtatta aaatctccta tgttctttga tttttggtct 274260 acttgtttta tcagttataa tgagaggcat attaaaatct tccatggtga atgtgagctt 274320 ttcaaaagca acattcttcc tttagtgctg tcaagttttg tatcatgcat tttgaatctc 274380 tttattaggt tcatacacat ttaagataat tacttcttct tgatggagtg actcttagca 274440 ttagaatata ctcctttttc tctctgggtt actatttgtc ttgaattgta ctcggtcaga 274500 tataaacata gccgtcgaga tttatgatgc atagtggttg gatagtatgt cagttttcaa 274560 cattttattt tcaaatatct atctctttat gctctaagtg tttcttgtaa aagtcattta 274620 tttgaatctt atttttaatt agtatgtaag tggtatttca tttatattta atgtaattat 274680 caatacaatt gtatttaagt attttaccag tatttgtttc tctttcttat ttcctgcctt 274740 attttgcata atccagcaat taacttttta aatatacttt gtgttatttt ttaggagttt 274800 gctagaaatt acagtatgta tacttaacta tcatagtcta attttcaatt atactaaact 274860 ttaaaaaaat ctaagactat cacaattata taattctatt ctctcattct ttgtattctt 274920 ttgtttcact gtattctata aaacttataa cacattgcta ctggttgtgc tgaaatgcat 274980 atatatgtac acacaaacac acacacacac acacacacac acacacaccc acacacacac 275040 atgttgagta tcccttatcc caagtgcttg gtaccagaaa tgttttagat ttcagatctt 275100 ttaggatttg aatttgcatt tgcattatat acttagtagt tgaacatccc taatgaaatg 275160 tgcaattctc caatgaggat ttctttggaa tgccatgttg gatctcaaaa agcttcagat 275220 tttgggccag gtgcagtggc tcacacctgt aaacccagca ctttgggagg ctgaggtggg 275280 cagatcacct gaggtcagga gtttgagacc agcctggcca acatggcaaa acctcatctc 275340 tactaaaatg ggaatatttc agattttgga tatttggact ggggatgctc aacctttaat 275400 atgtgcttaa tatattatgc aacatgtatg tctgtataca aacaaacaca catgtatatt 275460 aaatataata agtaggtcct ttatttttac ctatatgtta tactacctat gttttcattc 275520 tttcctgcag atttgagctt ctatcatgta tgatattctt tcagcctgca tttctttaag 275580 catttcttgg agcacaggtt ttttggctaa aaaaatctct gagttcttct ctagctgaaa 275640 atgtctttac ttagctttca ttttcttaaa ctgatacata ttagatgtcc atatcttcag 275700 gatacatgtg attttttgaa gcattcatat caagtgtaaa gatcaaatca aggtaattga 275760 gatatctatc accttgaata ttcatatttt atttatgaga agaatatttg aattgctctc 275820 ttctatagct tttatttttt tatttatact ttgactaaat gtagaattca atgtagaatt 275880 ctatgttgac agtttttttt cagcattttg aatttttttt ccattgtgag gaactcatcc 275940 atcattcttt tcatacttcc cctaaatata acatgggcta ttttttcttg ctacttttaa 276000 gatttctttt caattttttt ttcttttaag gttcacctct gatgtaccta ggtgtgattt 276060 tgaaataact ttttaaaatc ttatgttgtg gtttgctaat cttcttgggt atgtaccttg 276120 ctgtatttcc ttaacttaaa aaatattggc tattgtctct taaaatattt tttctcctgt 276180 atctctcttc ttcttctggg attccaattg tttatattga ttgatatttt tacacaggtc 276240 ttggatgctt tgttttattt ttttcatgtt taatttcttt gtgttttatt ttagatattg 276300 tctattggcc tgcctttgat tcttttctct tctatgtcca gtctgctatt aagcccatca 276360 aatgaattct tcctacctag tatcatacag ttacgtcctg atagttccat ctgagttttg 276420 ctttcaccgt ttgcttccca tgctgtagtt cttcacctgt tcacacgtgt cagtattttc 276480 ctctagagcc ttcatcgcag ctacaaagtt cctgagtgat aaatcaaaca tctgggccat 276540 ttccatattt gtttctgtta atgagttatc ttttaaacat gggccttgtt ttgttgtttc 276600 tttgtgtgtc ttgtgacttt ctgttttatg ctaaacattg tgtgcagatt gaagtaagga 276660 atgtttacct tgcccttgca ggaaggacat gctccttctg tccttctgtc gggctggtga 276720 tgtggggctg agtcaatctg acatgtggct gggctgtgct gggctctgtt gcagagttag 276780 gatcctgagc tagattctct ttaccttggg ttcacatggt gtgaaggtgg ggtcagcact 276840 ttgccttcag aagggcttgg gatctgagca ccagccagac tctttgaatc tttgtgcttt 276900 actgaccagt aaccagcttt ccaaactgtg ggagatctct ttctgcttta cagcttgcct 276960 gccagctctt tgagtttctg gggcattctc tttgctctct agacctgttc ttgactttct 277020 gtacctgggg agatctcttt ttgcatcaat ggactgccct cagcctttga aggccactgc 277080 agggtacttg gggaatgcag agatccacct cagttctcct gcactcatcc cagcttttgg 277140 cattcatttt gttcactaca tttgtccttg cttccttacg ttcataccac aaattttttt 277200 ttctgctgtt tgctaattct atgttctata tattattttt atattttaaa tttatatttt 277260 gctctcttga catctgaaat ccagtgtgaa cacacaaaaa ataagtagga aaaactccaa 277320 gtttcataaa ccttacctaa agaagtcatt tctaatttat tcataattga agctcctgaa 277380 aggtctgata cagctctggt acaagggagg tatgtcagtc agggtccacc acaggcacag 277440 aaccagtaag ttatataggg gacagataga aatctgaaga ggaagcgctt gaagtgtttt 277500 taggaattgg caattgctgt agcaactatg gggcggggct gagagtgtct gaaatccgta 277560 gggcaggctg tcagaaaggg ctggctagaa ctcccaggca ggagctgatg ccgcagttca 277620 caggagcaat tttcttcttt ctcagggaag cttcagtttt cctcttaaat cttttcgact 277680 gattgaatga gggccacgta aacgatcaaa gacaatctcc tttacttaaa gtaaattgat 277740 tacagctgtt aaccacacct acacaataac cttcatagca acacctagat aagggtttca 277800 tcaaataact ggaaactata gcctgaccca gttgatacat aaaactgttt atcacaagag 277860 taagggtcta ttccacagtg tggcacagta tgtgttaaag aataaactgt aaggaagaaa 277920 ataaatggaa gcaagaaaat gaaagggctg tgaatcctga catcatccaa cagcaaggca 277980 ccctggggcc agctctcctg cacagtgggt aggtctgtgt ccagttgagg gaccctcctg 278040 cacccagtga ctctcccttc ttgtaagccc caaagaaatg ctactaggca gggggataaa 278100 cagcctatct gggattaggc atcagctgtt actggagttg tctgggacag ccagctgccc 278160 agcacctgga gatgctgagg cccatgggaa tatgtgggcc ctgctgccaa gggaagaggc 278220 ctcctgctac agccctcgtg gtaacagaaa ggaggacccc cttcttccag ttggctcatt 278280 gtctagcctg ccctgagtga gctcctgggg cctctctcac atcattctgc ccactgcaca 278340 aaattgtctg cttatagggc agacattaaa atgctggtat tttattctca aagtgtaaga 278400 ttattattta tttttatttt gcctttctac ccatctgtat ttactaaaac ttttactatg 278460 tgactatatt aattctataa taaaaatcaa tataacttcc agcattttaa ataaaaatgg 278520 agacaagttt atattccccg aggaagaaaa tatcatttta atattttgta ttttccataa 278580 gtctccacat ataaatacct taagcatctc cttgaatgta cagcctggag tgtttctgtg 278640 cctgcagtgg tctgtgggaa ggacaaaaaa caccctaaga cctgggagaa ctcctttttg 278700 gaggcaatgg ggtagcttgt ataatcagaa tattggaaat gattaatcca aattcattgt 278760 cttttttcaa ctagaccagc aatcttaaag aaaaaaaata tatatatttg aaccatacta 278820 acacactgtg ctttaataag gatagacaag taactttgct aatatgctct ctttctcctt 278880 gcttcttggg aaactgtcag aatggtataa aatttagata agatgttgtg acttagaaaa 278940 gaatttgata caggaagaag ggggtggtac acatgcattc cccattcatt gctaaatgct 279000 tcaatcaaac atagtttacg tatcagaaat ggaaagaaga agagacagga aaacatactg 279060 attatctaca ctatcaagaa cactagaggc ggaggttgca gtgagcggag atcgcgccac 279120 tgcactcctg cctgggcaat agaatgagag tcagtctcaa aaaaaaaacc aaacaaaaaa 279180 acactagatc aagagtggta gttttgtaga gaataaattc ttatagaaag gaacaaaata 279240 tcctaaagac tgaattttaa tgtttttgaa actagtgttt ctgataattt tcaaatccat 279300 gccatttaac gaggaatagg cagagtgctt atgttatgcc tgatgctaat ctaagtttgg 279360 gaatgctaac acattagcaa acaaaacatc ccagcccttg accttgtgga gctggcattc 279420 ccgtgagggg agacagatgt tgggcctgat gagtaagtcc attgtagaat atgttcagag 279480 tgataagtag ggggaatgag atgaggaggg gcatttgggg cgtatggata attatagaga 279540 cagatgtttg tctgtgttcc ttgaagtggg gcttctttgg tttagtgcat ttactagtgg 279600 ataactaata aaaaacggct gcagtccctt gagccttatt tcacttggat gtccattgtc 279660 ttctagagca aattgttatt atttggtgtg gagaggagat gcggaaacgc agagctctgg 279720 ctgtgtcctg agcactaaac caggcacttt catttccatt tccttcgtct tagcaaggaa 279780 gacaaggagg cattaagcag ctagctacct tgcacaaagg ccgttcaatt aatgggtggt 279840 ggaagaccgg gaggccccaa agccggggcc aactatttgc taggcacagt aagttcagtg 279900 tctgaaacca ggatacgttt tggagcccat gacaattgtt ttaatttctt ttaaaatcag 279960 aaggaaaaac atatgtaatc cagcctgatt gtatttgtct ttatacttac agagtcataa 280020 aatgtaacac tgatttttgg ggagggagga cccatgagca tcttaacatg gccctgctta 280080 tgtgtcttta ataattctgt tgcctacacc ccttctgctt gttgtttctt ggcatttctc 280140 cttcgcactg aaaggatgct tgtgcttacg gacttgggtc atcttcaacc tgtgtccatc 280200 cccactttcc tgtgtctcac agagggccaa tgaagccaag gctgttgtca gcaagtatga 280260 tgctcagcat ttggtagggt gcaacacata tttgttcaat gagtgaatga atgagcaaat 280320 acatgaatac atgagtggag gaacctggca atagcagtag tggtgggtgg ggggatattt 280380 acttctcttc ctagcagact ttttttcaaa gaaatgtggc atcagcccac tgaatgttcc 280440 agccaatgaa attattttca aagcattctg tgtcacaaag cccatatggc tctgaactaa 280500 agggagaatt agaaataatc tgaaactcag ttaaagataa gtttgctaaa tccagtgcat 280560 gatgaattca aattactttt gcataatgaa taatgtgttg ggtggtgagt agcggtgtga 280620 aaagctaaat tgtgataaac gcaagcttgc aagagtcaat gaatgtctgg agagtcttaa 280680 actacttagg tgcagttgaa ggtcaaaagt tcagcaatgt ctggcagagt agatcacatg 280740 ggattctctt gattatgtta gtaagatttt atgatattac tttcagtgtc ttgtcttctc 280800 tggatgatgg ctggtaagca tgtttcaggc catggcattc ttgttatgat gtctccagag 280860 agactcccca gcatcactag ccatctaggg tggccgtttc tgagcgtcaa cagtgccaaa 280920 gcttctgccc tgtctcccaa agcacatgct tacagcaggc taaggagaaa accctgaaac 280980 atgaaatgta ggacaataat aatatatgtg aaagaggaaa aaggatgaca tcttaatgac 281040 tgatttagca gagagggttt acagagtttg gcttacgtct agacttaaac ccttttggtt 281100 tgagaagtca tgttttagtt atctttatgt gccgtttttc atgaagcttc tcttggctgg 281160 ggtgtaaagt tgatataaaa gggtacatgt tgttggttca tgcgttcatg ctgggggacc 281220 tgcatgtgtg gaaatgacag gagtgacaag agtccaattt tacaaaataa actgggactc 281280 tgaagttttg gaggcagaca tttgtgattc cttctgtgta gttgaaagtg attcacctgg 281340 cggtattttc cctctgttga agttgaatcc ccctttccat gtgatgttaa ggatgcatgt 281400 ggacaggcaa tatggccctt cttcagataa gacactctgg gctgctggct gcggttctgg 281460 gacatcttga agcccccgag gcactgagtg tgaacatgtg ggtgctgatg ataattcaga 281520 agctatttag aaggtaggga cagcaatgga attttgtgga aattaattcc aatgtaagtg 281580 tgatatgtca cttatccaag ggtgttcctt atgtgtgacc tatttctatg acatcagtgg 281640 catgaggctt ctctgtgaac atattaatat cttggcattc tttggttgag attagcatca 281700 gtcagaagct gtggataggc tagagtcagc tcaaaaaccc ctgatcacct accctgaccc 281760 ctgagagttt attacgtagt cacagatggc ttctctgttc tataagagta gaacttcctc 281820 ttcatggtct tcttcgagct acagtgtctc taatttccct aaatggctgc tcaactgtca 281880 agagatgtaa gccctattag ccgcattggc cattcagcta tagacaccca gtagccatgg 281940 tgggtagcag agcaggtctg gctggagagg agaagccagt acctcggcta ctggaaggca 282000 gcaggcatac aaaggctgca cttcttggct cctgtcttat gtctttactt tgttgtcttc 282060 acaacatggc cttaaagtat tttggaaatg gcaccgtgtt gggtcatgtg tgtcagggga 282120 gcagtatcct cccctccacc tctgcccatc ccacctgggc ctcttccctt ccaatctcca 282180 ggtgctcacc ttggaggcac agggagcaac taggtctgta cagcacacct tgctggcaca 282240 ccagttctcc ttattgccaa gcagcttctc accctaatta ggtattaaaa taaacttgca 282300 tttgttatgg aaagaatgtg gctttgtgtg tttttaaggc aagacacaaa attttaggaa 282360 attttatttc ttgactggca gaataggaca cagaagggtc tagccttggc aggttcccgt 282420 ttcacgtgct cattccattt agtcttgaaa acaatcccat gagtagagac agacctagag 282480 aaaggaacaa agtggctcaa agtgaccttt ttgtaggagg cagggttggc aggatccagg 282540 cgagatactt ggtgctgtcc tcagccctaa gtccatgccc caaaacaggt caaaggaagg 282600 ccagaagtat tgatagagaa gtagaggaag gaggagggtg gtgggaggtc aacgctgagt 282660 aaataaagca acactgcctc ttccctctag cttctttgtg tgcatagtca gaacaatttc 282720 tccaaattta ctctgaagat tagttactgg catccgtgaa gaacttggaa gggacaaacg 282780 taccattgtt ttcatttttg ttcctcacag gaaaattcat actctcaaaa tcattgtttt 282840 ttcccctgca gtggtctgtt ttgtagagtt ccctaaccac tttgtttcca gtggtaactg 282900 tgtactttcc tctgacacaa gattttaagg aaaagaaact accaaagatg ttttatgttg 282960 atttcttttt ccatatttag gactgctgac caagcacatt tattgtggtt atcattaaat 283020 gtttgacatt tacaaacagc agggcacaga gtacgcatct ctcagatggg cgggaagcct 283080 gagaaccaag ggctttcagc cgcgtgcctt ttgcatggct ggccttgctc acagctctgc 283140 tctcactctg cctcccttct cccctgaaat gtgctttttc ataggaggct ctttctgttt 283200 tggttttcct gtttttatgg ctctgcttct aaacatataa ctatatataa acatataaac 283260 atatataaac atataaacat atataaacat ataactatat atacacatat aactatatat 283320 aaacatataa acatatatat aaacatacaa acatatataa acatataact atatataaac 283380 atataaacat atataaacat aactatatac acacatataa ctatatataa acatataaac 283440 atatatataa acaaacataa acatataact atatatacac atataactat atataaacat 283500 gtaaacatat atataacata taaacatata aacatataac tatatataaa catataaaca 283560 tatataaaca tataactata aacaaataga tatattttgt tttacaaatt tttattttgt 283620 tttatacata tataaacaaa tatatatata tatttcaaaa tatagatagt attatcattg 283680 atctggtgga actctgagaa tttctggatt gaagttctca gagttccacc agatcaatga 283740 taatactacc tgtatttcaa aatataggta gtatttctgc tgcttctcta tgatgtgtta 283800 gtagtagatc tcttgatctc aggtgacttc aagctgggag acaaactatc tttgtttagc 283860 aaggacagag aagttaacca gttgcatgac tttcagtaaa aaaaatgaga gagtcctgga 283920 caaaccaaga cagttggttg acctgtgagt ggtttcagtg tgcaagaaca cactggcagt 283980 tttgacattt tgagatgtgg tggctctcct agataataaa ctgtcttcca cttctgtgta 284040 agcttttctt agggataact caccctgctt cagcaaatcc gggcgattgt ctctatcagc 284100 caaattctgc acatgtagcc tctgaatcta aaataaaaat tgaaataaaa agaaaaatat 284160 aagatgcttt gtttttgcgt ctctctctcc tagccgttga cttttagtgc atgtcgtgca 284220 ggcgacagac gtattgctgc cctttctgtc tctggtcctt tttctagggc aggatccaag 284280 tagtttttgt gagcattgca gccagggatc atttcctctt tcccttttag ggccacaata 284340 gtgacctcca gcagcactgg gtactgaaat acagggcttt ggctttccca ggctcataca 284400 catagcagag cgtctggttt aaggtctgta taattttgtg taattatatt caattgctca 284460 ctcaatctct gatcactttc taatgagctg ttattttcag aggtagtaga aaaatcagtt 284520 caggaagaga tgatgatgtg agagaaataa atagcaaatg actagtgagg agaaattaca 284580 cagtaaacat gatgctgagc tttctctgag tgagtggtgt gtctagggag gtgtattatg 284640 aagtacattg ctatgaagaa cggcctgaga ctgggtaatt tataaagaaa agaggttaat 284700 tagctcacag ttccacatgg ctagggaggc cccaggaaac ttaacaatca tggcggaagg 284760 ggaggcaggc acatcttaca tggcctgaga gagaaggtga gagagcatgt gagagtctgg 284820 gaaaaactaa catttataaa accatcagat ctcgtgagaa ttcactcact atcatgagaa 284880 ccgcatgggg gaaactactg cattgatcca gtcacctccc accagctcta tccctcaaca 284940 cctggggatt acagtcaaga tgagatttag gtggggacac aaagcctaac catatcagga 285000 ggggtgtgtt agttgagcag acacagaaaa gcaaaacatt tgagcccaag agtggaaccc 285060 atcccttata aggagagacc acgatgtggg gaaagtcagt gaaatggaca tatggctaag 285120 tttgtttagt gtttgaaaat gtcaccgaag tcacttttta ataatgaaaa atatgtggat 285180 tgaagagttt aaaagagaag tatgcccaga tgttatttta aaaattggag tgtatacaaa 285240 gggcccccaa atctaggctg ccttagtatt tttgccccta gctttgtttt cccttaagtg 285300 atgtcaggaa ctgccagtgt tggcctctgc atctccaaaa ctgaagacag cttagttcac 285360 tcggtctcgt cattattgtt tcatgaaagc atgtcgttgg gagatctggg ctcagaccta 285420 agattgaaac aaaaaaggaa agagaaagat aagaaaaccg tctcattttc aaaaaccttc 285480 acaaacccca cgttttatta aaatataaac catttgaaga aaagccagag gaaaatagag 285540 gaaatggggt atcactgaat gaagcagaag ctaaaggatg atcatataaa ttgtctcaaa 285600 tagcaggtca ggaaccagtg gcctgtcacc atgaaaacaa agttagggga aatagacaaa 285660 tgaaaacaag tgagtttaca ttattcctaa gaactttctg ccggtgagaa aataatggaa 285720 cgacgtgtag tcagcataca cacaggaatc tatattttgt aggttatatt tcaaaggatt 285780 catgtaccct gaaaagaact gttgactgta gggtaagtta acaccagggg gtgctgggtg 285840 caggcacatt gaatctgaac tactgggttg ccattttaga ctgttaccat catcactgtt 285900 accacacctg tagtttaggt cattagatag gtgtggaaat gaagcctggc tccttatcaa 285960 tcgaaagcct atgctcttac caaatacact atgctattta atattggtaa tattagtgaa 286020 atttagccgt ttcagagttt tccttctttc cccaaagcat catttgtcaa tgtttgttaa 286080 catacgacac ttaatgtaat cctcataaac aaagtggaca ccctcaagtt gttttctggg 286140 atttttacat aagcatatgg tccttgagca atgatggttt gactttacta tgacaatatt 286200 tggctttacc gtggtgtgaa agtgatatgc attcagtaga aaccatactt cagatttcaa 286260 actagatctt tacccgggct agcaatatgt ggttccatac tctcttttga tgctgggcag 286320 aggcagcaag ctgcaatccc cagtcagcta cactgtcacg ggggcaaaca accggtactc 286380 tacaatgcat tgtgttgcca gctttttttg gatgtgattt tgcccaactg taggctaatg 286440 tgagtgttct gagcacattt caagtaggct aggctaagct atgatgttca gtatgttaga 286500 ggtattaaat gccttttgac ttgtgatatt ttcaacttac aatgagtttc tccagacata 286560 atcccactgt aagtcgagga gtcgctgtat taacaacggg tagactgaaa acaccgatgt 286620 gcaaacctgg ttcagtacgg atggggtgga catcggcatc agggttcttg tgaatattcc 286680 ccgggaacat ggggaacgtg gtgttgtgaa atctagagct ggccaggaat ttccggatcc 286740 ttacctccag ctttccaccc cacacagggg gtccccctgg agccacctgc ctacctgact 286800 gcttatcttc cagcctctgt ctgagcttct ctaggtaact cctacatcca gggcaactaa 286860 tttcctggag caacagaaga gccttccttg tattgagaca acatgcatgg tctccctgca 286920 aatgctgcct ctctgctcct acatcttcac attttagtgt agaaagagca atcgtgggtg 286980 agaatttaag cacaagtgtt tagttcaaaa gacagaaaat tggccacgca tggtggctca 287040 agcctataat cccagcactt tgggaggcca aggcgggcgg atcacgaggt caggagatcg 287100 agaccatcct ggctaacacg gtgaaacccc gtctctacta aaaatacaaa aaattagccg 287160 ggcatggtag ttgggcgcct gtagccccag ctactcggga ggctgaggca ggagaatggc 287220 gtgaactcgg gaggcggagc ttgcagtgag ccgagatcgc gccactgcac tccagcctgg 287280 gagacagagc gagactccat ctcaaagaaa aaaaaaaaaa aaaaaaagac agaaaatttt 287340 aaaagcatca aaacagccgt tacagagagg gaaaaaaagt tcttaagtat cttagaactg 287400 cttcatttca atagatgttg caataagctg acttctatat gacttatagg tcccgaatca 287460 ttgatattta tgtttgcaaa tttgtgtgtt ttgtgtaaat gagatcccag aactacaaca 287520 taaacttcta atgaactctg tttctatacc tatgtggatc ctgagaggtg ctcaaatatg 287580 agaggctgtt tctcttaacc tcctattctg cttaaaatca tttgtcttta cttgtacttt 287640 tttttttttt tttttgagac ggggtctcgc tcttttcgcc cgggccagag tgcagtggtg 287700 cgatctcagc gcactgcaag ctccaccccc cgggtttacg ctattcttct gcctcagcct 287760 ccccagtagc tgggactaca ggcgcccgcc accgcgcccg gctaattttt tgtattttta 287820 gtagagacgg ggtttcaccg tgttgaccag gatggtctca atctcctgcc ctcgtgatcc 287880 tcccgcctca gcctcccaaa ggtctgggat tacaggcttg agccaccgtg cccggcctac 287940 tttaactgga gaattcattc ttccaaatgt gctcattcat ggttttattt tattttattg 288000 cattggattg tatcattgca tctcctacct gtgcatttta agagtttcca cttcaaactt 288060 tgtttcatta tgaggtaaac cttaaaaaat aaagcctgtt ttctggagtg ccacagacat 288120 tttgtcagaa gaaaatgtga ctgtccttta atcgggcact gttttatgca cataatacaa 288180 atgatttctg catgcttatc agatctactt gtgggcttat aaattcactt catcctggca 288240 tacgtagtga aggacattcc tctgtgccct gtcaagaata atcaagcttt taaaatcaat 288300 tccagtggtg ataaaaataa cgaggatggt ttgtgaaaag ggacaaaaac ttggtaaaaa 288360 taacattgaa ggatttacaa tatacagaga gaaagtgaac catctctttg aaaataagtg 288420 taaaaaagaa aagtgtatct aatattttta ttgatgcata agctatgaag agaactatca 288480 atgtttctgt cttgctctaa atgagatatg actggtggga tcccagatca tttgattatc 288540 cgtttgcaga ctgctctgtt tatttaaaac ataattcact ctctcattct atagatggac 288600 ttactagata ggagtctgtg ctttataagt gaaattaact tagataattt tttttttttt 288660 ctttttgaga tggagtcttg ctctgtcgcc caggctggag tgcagtggtg cgatcttggc 288720 tcactgcaag ctccgcctcc caggttcatg ccattctcct gcctcagcct gctgagtagc 288780 tgggactaca ggtgcccgcc gccatgccca gctaattttt ttgtattttt tagtagagac 288840 ggggtttcac cgtgttaacc aggatggtct cgatctcctg acctcgtaat ctgcccatct 288900 cggcctctag atcattttaa tgacaactga taaagagata atcaaatgat aacctgtttt 288960 tctcagtgat agaaatatgt gatggaaagt atctgagact aatgaaagac atggaaacta 289020 atttaccgat gatccttgga tactagttat ggaagtatac ttatattatc tatgcaaata 289080 tacaaggtct tttgaaaacc ttttacatgc ccaacgccaa atatattaag tgaagctaca 289140 caataagata ctgtaggatc agtaaacagg tattgctaac gtttgtagca aaatcctgtt 289200 gatccacatt gttgggtctt tcttggtatg gtctagtgag atatcagtgc gtgtgtatat 289260 atgtatcagt gcattttagt tcattttgtg ttgctataac ataatactgg aggctgacaa 289320 attaagaaga ggtgtttgct tggctcacaa ttctgatggc tggaaagttt aagattgagc 289380 atctgcatcc agtgagggcc tcaggttgct tccactcatg acaaaaagca gaagagaagt 289440 gcgcatgtac agggagatta catggtgaaa aaaggaagca gctgggcatg gtggctcacg 289500 cctgtcatct caacactttg ggaagacgag gtgggcagat cacgaggtca ggagatcgag 289560 accatcttgg tctctactaa aaatacaaaa aattagccgg gcccggtgtt gggcgcctgt 289620 agtcccagct acttgggagg ctgaggcagg agaatggcat gaacccggga ggcagagctt 289680 gcagtgagct gagatcgcac cactgcactc cagcctgggg gacagagtga gactccgtct 289740 aaaaaagaaa aaaagaagca agagacaaaa gccaaataag ccagactctt tttaacaaca 289800 tactctctca ggaattaatt cccgagagaa ggggaatgca cacctgaggg agggcattaa 289860 tctattcatg aagtatttta ccccgtaacc agaaaaactt ccacttggcc ccacctccca 289920 acactgccac actggggata aaattttagt atgggttttg gcagggacaa accacatcca 289980 caccatagca gtaaatattg atatacagtt gacccttcaa caacatgggt ttgaaccgtg 290040 caggtccact tacatgtgga tatttttcag taaaacttac actgggtgtg cctgcctctc 290100 ctgcctcccc ttccaccttc tccacctctc ccacctctgc caccccagag acagcaagac 290160 caacccctcc tcttcctcag cctactcaat gagaagatga tgaggatgga gaactttgtg 290220 atgatccacc tccatttaat gaatagtgct atgatatgga tatttattcc cttcaaacct 290280 catgttgaga tttgacccct gatgttggag gtggggccta gtaggaggta ttgcgtcatg 290340 ggggtggatc catcataaat aggttaatgc catccctcag gggtgagtga gttctcactc 290400 tgtgagctcc ctccagagct gatatttaaa aagattctgg tacctcccct ctctctctct 290460 gacttcctct gtctccatgt gatcttcaca cagttggttc ccctttgcct tccaccatga 290520 gtggaagctg tctggggttt tcaccagatg cctaatcttg aaccttccag ctatcagaat 290580 tgtgagccaa ataaaccttt tttctttatg aattattacc cagacctctg tatactgtca 290640 tagcaataca aaatagacta agacatatag tagtatattt tctcttcctt acaattttct 290700 taataacgtt tttttctcta gcttgcttta ttgtaagaac actgtattta atacagataa 290760 catacaaaat atgtgttaat tgcctgtttt tgttatcagt aaggcttcca gtcaatagca 290820 aactattagt agttaagttt tgagggagtc aaaatttata catatatttt taactgtgtg 290880 gggactggac actgtggctt tgttcaagag taaactaaat acatagaatc tcatcttctg 290940 aatattataa acattattag acgtgtcttt cctcaaaggt gattattcta tatagtgatt 291000 tggtttggag gtagaaaaag tgcagagaaa atttaagcaa atattaaaca tcactttttc 291060 ttctatacac tctatttttc ttactgacag aatttttctg gaacatttaa cagtatcttc 291120 taacaggtac ctctctcacc caacttgtcc tcaagtaatc cccctacctc agttgagctg 291180 tatatggtgg ctcacacacc tgtaatccca gcactttggg aggccgagga agggggatta 291240 cttaaggata agacttcaag accagtcagg acaacatagc aagaccccat cgctgcaaaa 291300 aattaaaaaa aatattagcc aagcatggtg gtggacacct gtagtgccag ctactcagaa 291360 ggctaaggca agttgatcac ttgggagcag aaatttgagg ttatagtgag ctatgattgc 291420 actaatgaac tccagcctgg gtgacagaat cagatgctgt gtcttaaaaa acaaacaaca 291480 acaaaaaacg ttggtttgaa atttgacaaa atgttctgca ttcacattta gaataaacgt 291540 tttatatgag gaagttaata tgtcattttc tataattaaa tacaatataa tgtgggttta 291600 aaatttcatt ctgattctta ttttggcatc attaaatatc attactcgat cttgatattt 291660 agaaggtttc agaagccaat tactagtgcc tcaaaaactc agtactgtgg aaatgacata 291720 tcattgggtt ctggtaatga ggaatgacta tttttctttg gatgttacta tcaaaacatt 291780 tttataggca tctggaaaat atctgcctga ttaaagagct gtgttttaaa tgctcaagat 291840 cacgtgtgct tttttcttcc ctgtgttccc caagcaaatg gaatgccatc tggattctag 291900 atttggcttt ctcatgtaat ggatgtgaga ccctgagcta gttacttaac atcatcaggc 291960 tttctggaaa gtgaggatag gaatgcctga atattgaatt taaaatattc aagttaatca 292020 tgtataaact ataaagattt ttgaaatata aaatatgcat catttcattc actcactcac 292080 tcattctttt atttgttaat tcatccacca tttactgaat gccttctgtg cactaggtac 292140 tgggcttggt gctacctact ggaaaattaa taaaacattg tctttaaggg gctcacaatg 292200 taatggggga aatcaccaag aaaataaaca atttcaatac catgtgtcaa gtgttaaatt 292260 ccagtacaac atgttggtgg ttacaaaaac gtaaaaacaa aaatgaaata ttatgggagc 292320 agagattaca cttagtatcc tccagaaggt taccaaaatc cattttatat tttacatata 292380 gtttgttctg tcatcttcta agaataccta aaaataggaa ttacctctat aattttaaaa 292440 aataatttag tgcaatacag cataggagga gagtatgtct ccctctatgt gagtggataa 292500 ccgtctctgt aatatatact tttctgagat ttgttactca tattctttac tcagtactat 292560 attcagtaca caatggaatt cctgttactg ttgactagat gactgtcgaa attggctcat 292620 ttccccaaaa ttgtccacaa ggtgaaggac ttgaggggtc cctgaaaggc taggtccaca 292680 gaagaacttt ccccatggta ctggccaggg gaaaacattc ctagtcagag acaagtattt 292740 ccaggattta aactatcttt ccatttttgt aagaatgata gctgcccttt cccctggatc 292800 ttgcacctaa gtaagactta gcagaagcag tctaatttta ttgtttgcag ttatgttcta 292860 aaatgttttt aattcgttta atccaacaat ttgtcgcatt aaaaaaaaaa aaaaaaacta 292920 acaatcaaaa caaacagcca ggcatggtga tgcatgcctg tagtcccagc tactggctac 292980 taaggacact gaggcaggag gattgtttaa gcccaggagt ttgaggttgt agtaagcgtt 293040 atgacatctg taaatagcca ctgcattcca gcctggacat ctagcatgac cctgtcttaa 293100 acaatacctc tacaaatgac aacaatgaca agcaccctga ttcaagatct gggatttttt 293160 gtttcctcct ccgcttggct ttgctctgag gaggataagt cacgtaacct gttgggcctc 293220 agttttgtca tatgataaat gagaaaatgg aactaggtga tctttcatga accttttatt 293280 tttaacagtc ttgttttagt gatcctatga ctctgtcaca gaatgttaaa aaaaataatt 293340 cagaagaaaa atttacaggt tgaaatggat ttgagaattg aagcatgaat tgctggcagg 293400 tgtttgcaat atacttttgg gtgcaaacgg atgtgttatc ttgggaatga agagtgagaa 293460 gcatttagat atcacagttg ttggctagaa gaggaaggat tggttaaaaa attaaaggta 293520 tatttggtta atgatatata tgtaaaaatc ttatttgttt gcaaagagtt agacacatct 293580 gaattttctt acattataca ttgtaatgca ggggccttct tgcagggcct tgggatgtgt 293640 cctgtacaca aataactgat acctcctgaa accttgcatc aggggaatcc tggtggattt 293700 ccacattatc accacaggcc tttcaatata aaatgctgat ttgaatgaca tactgtcatt 293760 gagttgatct ctaaaagttg ctggaaattt tcagaagaac ttgatcctca gatactacat 293820 atgccctttc caaggcataa aaggtaagtc cagtggtact ttcataaaag cactgcttaa 293880 atatataaac aaaaacattt tgtggagttc tacaatctag aaagaaatgt gacttgtgct 293940 gtttcttctt ttatttttaa aatccaccaa tagaaactgt ccctaagagg ctttgtcctt 294000 taatcctagc tgattgttaa acggtttgtt attaatatct tacaattcag tgcagatggt 294060 tttgagcagt gatcagatga acaaagatgc ttagtgatgg ttcaatttcc gggttggatt 294120 tgcatcctaa tcttagtctt aaaaaaatta gaaagctgtt tccacatgag ctgtataatg 294180 ttttactttt ttactacaat tgctgtaata cttcagtcct taagcataga aaataatgcc 294240 cattattata ttgggtgaaa tgaaagcttt ttaagtgtaa aacatgtaat tgtagtctca 294300 aaactattta tgtggcatca attatggtga aattagttca tgaaggtagg tgaaaataca 294360 taaacattgt gtatatgcta attcatctag ataagaattt tcatgtagat ttggtcagct 294420 gtgttagatt taaatgtagt ttcagatctg gttcagatgg aaagtagatg aagctgccaa 294480 cctttggcag cagcacacag gtggaatagc tgagatagaa taggtgattg gtgaagaaga 294540 tagaaacatt tctaacacat agaagatttc aggacagtga gtgtggcaca ttctagatgt 294600 ttcccacact gcagcaatgg gagatataca gatcttcctc agtaaacccc tatttctaga 294660 ctacgtgagt ttccagttga atcagatttg agaaatgcag tgtgctaaag gcagctcttc 294720 ttaactccct ctgtgaaccc aaggaatctg tctcattcat tggaagggtc taggaaggga 294780 agagaactct tttttttttt gagacgaagt gtcactctgt tgcccaagct ggagtatagt 294840 ggtgtgatct tggctcactg caacctccaa tgcccaggtt caagcaattc ttctgcctca 294900 gcctcctgag tagctgggac tacaggcaca cgccaccatg cctggctaat ttttgtattt 294960 ttagtagaga cggggtttca ctatgttggc caggctggtc ttgaacccct gacctcatga 295020 tccgcccacc tcggcctccc aaagtgctgg gattacaggt gtgagccacc atgcccagct 295080 ggaaatagaa ctcttacaat ttttctgagt ttatctcttt acatcagctg cctccttact 295140 gtaaaccaaa aaatacaagt ctaagccccc cagctgactg aatggacaca ccctcttggc 295200 caaagggacc caaggaaacc tgaaaaggta gttcaggcca tgacaggaac agaggccatc 295260 agacatgtct cattatacac tctgcctttt ggagtttaga cacgactgag cagcattaac 295320 attaaaatag agatcctaag atggacagaa agattcttca tagcaataag ataccaaatt 295380 ccaacctaac tttagtataa tatcacataa cagataaaga aggaaatcaa aatattttac 295440 cccaaaatat ctttccttgc catattttgg aaatggttct gcaaagctgt cttttgtggg 295500 ggaaattttg cacctgtaag gaatccctat taacataact agatctttca tcttccaggc 295560 cctcccaatc ctgaagagat taacagagag tctagcacct tttaaaagtc tgaatgggaa 295620 acatttgcta tctattgtct ctaagggcag ccacctatga gacttcatct acataataag 295680 aacctcagtc tccacaaccc cttatcttaa tccagacagt ttctttctac tgattccagg 295740 tctttagata ataattggtt ggaataattg acaattccaa ccaattgtca atcagaaact 295800 ctttgaatcc acctataacc tgtgagcaac acccccaacc acttcaagat gtcctgcctt 295860 tctggactga accaatgtat acctcgcatg tattgattga tgtcttatgt ttccctaaga 295920 cgtgtaaaac caagctgtaa cccaaccacc tgcagctcat gtactcagga cttcttgagg 295980 ctatgcctca ggccatggtc attggtattt ggctcagaat aaacctcttt aaatatttca 296040 gtttggcttt tttcattaac actacacttt ttaagtttga cctaaaggtt tctctgtaca 296100 tagtgaactg tcatctaact ggacgtgtaa agggactgta atctacactg taacaagtag 296160 ctgagtctca gccaatcaca gcatcccagt ttcagccaat cacttgcatc caactattca 296220 aactgagctc aaataagcct gtaagcagcc ctgctgtttc tgtgcctctc gtcccttttg 296280 tctacctcac tttccttttt ctgtccataa atgttatccc aaccatgtga cagtccctca 296340 gttactctga acatattatg gttctggagg ctgcccaatt ctcaaatcat tctttgctca 296400 attaaactct gttaaatttg tctaaagttt ttcttttaat agctactact actctagaga 296460 aatatccaca aagacgtaat gtgtttgttc ggaatacctt gttgaatgga aagaagggtc 296520 tgtcctaagg gacaattgca aggattgaga cacttggtgg caattttgag gaaaaagcaa 296580 tttttttttg agatggattc ttgctctgtc actcattctg gagtgcaatg gcgtgatctc 296640 ggctcactgc agcccctgcc tcccaggttc cagtgattct cctgcctcag cctcctgggt 296700 agctgggatt acaggcgcgt gccaccatgc ctgagtaatt tttgtatttt tagtagagac 296760 gggattttgc catgttggcc aggatggtct caaacttctg acctcaggtg atccgcccac 296820 ctccgcctcc caaagtgcta ggattacagg catgagccac tgcgcccgac tagtaaaata 296880 tttttgagta gatggctaaa cagcagaaag ccctgggagg caggacggcc cagagaaagg 296940 atattggttg agctgagtgt caggcctggg gctcggtgtt ggtgtggatc tgggatccag 297000 ataccaatga ctagctgggt gatatcggac atttcctata ggtaggacta gtattttggt 297060 agggttcttt tcatttgtaa ataacgtcaa gaactcaaaa taccaagcgt agggcttgat 297120 gctccatgga tcctccataa agcaagactc tttgcttagc ttttcattat ttcattcatt 297180 tcagcattta tgtcagtgtg taaaggatac agcaacctgt tgacttagcc agcacatttt 297240 ctcagcttag atactggtag ttaacagtat tatttatctc gtcttgcatg atgtacctct 297300 aagaggtttg ttcatcacca ccatttcacc acagcccttc tccctgttag cttagctggg 297360 gtttccaaac gtcaatataa cagattaaat ttctttgtta aatatgaagg tgagtgagct 297420 gaagtatgac ttgtcccaaa atgtaacacc ttatgagaca ggcctagaac ctaggtcttc 297480 catacccttt catgctgcct gagtatctca gtgtggttgg cagcctatta aaacacagac 297540 ataactgatt caactcaggg tcacaaatgt acatatcagg gaactttgtt ttatttcgtt 297600 tggtcatatg gatgctgaga gaaggtagtg taaggaccac tgcttaccgt tctcagctgt 297660 tctcttccta agcgcaagta gtgggaccct cacagccctg gatgcattgt tgtttttttt 297720 tatctcgaag taaatgactg aagaatcagc aggagttttc cagaatgaaa atgtaatacc 297780 ttggtctgtt tggaactcag tcaacacctt aggaatgttc tgccaagctt gtttatgtta 297840 caaattaaat gtatgtatct ttaatatttt tgttgttggt attctctcaa aacaagaaga 297900 taaatgacat ttttaatgtt ttttttgaga cagggtcaca ctgtgttgcc caagctgaag 297960 tgccatggtg caatctcggc tcccaggctc aggtgatcct cacgcctcag cctccagagt 298020 agctgggacc tcgggcgcac accaccacac ccagttaatt ttttgtattt ttggtagaga 298080 tggggtttca ccatgttgct caggctggtc tcgaactcct gagcttaagt ggtttgccca 298140 tcttggtctc ccaaaggctg ggattacagg catgagccac cgtgcccggc cttgttttac 298200 cctattttga ttcttccatg gcttttggaa aatgcactag atttttaatt ctttgggcca 298260 ctctcagata aaatatcgct gtgtactact attgacatgt taatttgtct tctaacggac 298320 aattatatat cccaaagtca tgcctaccta atggtacttt aaaaggacta atttgatgat 298380 cactgttgag gatgtagaaa ggctgtgacc ctggcctttc aaacacattc tattcaattt 298440 tgcaaattga gaaggaaagt aagaggagaa agaaaaaaac tgctgtaata aaattggaaa 298500 ttgtttcagg aaattgcacg tgctattgag atctttctct gataatttag aaaaggaaat 298560 acaaattcta ttatatattt tatattgtac atatatatat tttttttttt actggtttat 298620 tttcagttga agattaatta catccaggat tgtaaattgc tcacgggtca ttaccagtca 298680 cctactgtct tgcagcagag caggaaatca gatgtgggcg ctttaagatg agctggttta 298740 gcgttcactt acttaaagat cagtaccaag ccgaaccccc ttgggaggag tcgatggctc 298800 atttggcccc atggggaggg cggtaattaa actctgaagg cagccctgat gttcagctaa 298860 aagctggtct ttaaatagta atacactcgc cttgtaaagt gctaggccct cgggtggctg 298920 ttgacacagt gcgaggagct ggcgcttttt tctataaaag ccaaattgaa gaaactgtta 298980 tgaactcatc tgcataaagc aatatgattt tgcctgaggg tgcaggcaat ggggagtgat 299040 taaccaaccg gctctctccc cgctcctccg cagctctgct aacatgccac ttgtcactaa 299100 aaaattggag acaccatatg ccaggctgcc tctgctgagc gccccttact gatgccacgc 299160 gaggaatccc tccccaattt ggggggctgc gggacactgc gcagtgtctg tctgtagagg 299220 aaatgctgcc tgcctgcctt cgtcttgctc cctgcctttc tcagcaagga cattccattg 299280 ttccagggaa cgtggcagag acgttctgag tttgcttgaa caatttgagg cacatttgaa 299340 ggacagtgga agcattgctc cagaaaccca gtgtccagac atcttgtttc ctctcctccc 299400 tgtgctgaag gctggaagag gtcccctgtg gctggttctc atgacctgcc ttttgattcc 299460 accggtgtct ttgtacttgt gcaggaaact caggagggca tgccttcctc ctgcaagcct 299520 tttatttctc ctaaaaccta ctttgcgttc tgtctcccga tttttctgtg ctccattaat 299580 tatgcaaacc tcttttgatt caatgtgcaa acagtgcatt aaggttttaa ccttgaggag 299640 aatggttttc atgaggcctg acagctgaat cccaggactt ggaaaaggag acgactgtgt 299700 ttggcttttg aagaattagc tttcacgtcc ctccgggtga taggtttggg tgcagagtgg 299760 cttctgggct gatttgatta taagccacca ttttgtgttt ccctcagtca ccagaattaa 299820 gatctttcta acagcaggcg tgtaagaagc aagaaaggaa ggccgtggtg tgggagtgtg 299880 gagaaaaatg gattctagaa aggttagcag gctgtcttcc ttgctgctat tgtgtctaca 299940 ccgggggaca gtggggtcat gtctgcctct gggctgtctt ccccaggata gacagggttg 300000 gggacagaga ggacggtgag gattccccat gaccaaggtt gggctgctct tggctctgtc 300060 ttagttgctc tgcttgatgt tatgagggga tttggatggg gttgacatgg gcctcaagaa 300120 gaaatgcttc tcagccccct tgcccccaat aactgggggg tatcagcctt tagaaaggat 300180 cctccaggct cccaccccag ccccagcccc tggagcaaaa ccacattctc actaggcctc 300240 tcctgaaaag gggaagtgta agacgtgact tcccttagaa agacctgagc ttctcttttt 300300 ctatgggttt tggggtgagg ccagcagtga cttaatccca ataaatatta aatgagacat 300360 aaatccaact ttagcaaatg tcacccacag atttttgcta aatcaaactt atttgtattt 300420 tattttttta aatggatgaa cttcatctcg aaggaatata aaaaaactga caaaccaaag 300480 gccactgagg tccatgcatg gactagggag gaaaacccca tgtatttact gccagatcca 300540 tgccaggagc tgtgcttggg cgaagccata gctggtggca taggtattgt caccccctac 300600 tcctcacatg gaaactgagg tggctcagag aagtctacat gatttgccta aggtcaaaag 300660 gcagggaagt ggctgttatt tgaatccaga tctgtcagac ccaaagccca tgatctgttg 300720 gccactttgc cgtttgcttt gggccagagt ctgcctgagg ccctggcaga gatgtcactg 300780 actgggcggt ggcccttttc cagatacata tccccatgac ccaaggaaat gctgctcaca 300840 gctaccctga gtgtgtggac ccccagctct cctgcacagc ttcctactga aaatatctcc 300900 ccatagatgc cttgtgaatc attttcccaa gaaaaggact tctctacacc ttaaccctct 300960 ttaaaaatgc ttgtgtccta ggaggggaga atgtacccgc tgagtttcat gcaggggtct 301020 tgtcagggaa gacagaatga gtgcctatgc actgccaggt cctggtacca gatcacatca 301080 tttaagtatt acgaccaggt tactagggat tatttggatc ttcttttgtg gaggagggaa 301140 caaaggctcg ccaaggctgg aaacccacca aggtttccca ctggtagaga aagcccagac 301200 tggacctgac tttctgttcc caaagccctt gacacgtggc cactccagtc actggttttc 301260 tcagtgacag actggctggg ctacacacaa gggggctagg ggctgaagcc actttttgag 301320 gtgactcttt gttctcccct cattcagtaa gtgttggagg ctggtgctcg gagccatagc 301380 cagaccattg ctggtgccag ctcaatgcct gcagtgtgct gggatggtgt gcatatttca 301440 cacatcatct cacacaattc ttacccctgc caagtgtccc aggacacctg ttttagagat 301500 gaggaaactg aggttcccag aaagtcagtg gcaggtgcaa aggtcatgcc tctttgtgtg 301560 acttctctgt ggtctgtctg gtttcccatg acatttctgg cttttataaa ctattaaagc 301620 acagactgaa agaaaaagtg ggactttgca ggtgaggctg tttaacgtgc tggaagagtg 301680 aatatatgta aaatttcgga tattacaggg ctgcctatcc ccagtggagg ttgtctgggc 301740 agaaatgatt tccctgattt gtgaagatta ataaatattt tgtaggtcct tggtcaactc 301800 aggctgctgt cacagaatac catcgtctgg gtggcttaaa caacagacat tgatttctca 301860 attttagggg ctggacatcc acaatcaaag caccagtaga tgctgtgtct gctgatgtcc 301920 atgtggcttt cagatggtgg ccttcttact gtgtccttgt atccctacat ggcacagagc 301980 agaaggacag aacacaagct ctcatgtctt ttcataaggg cactaatctc attcttgagg 302040 gcttcatcct catgacctaa tcacctctca aaagtcctac ctcctaatac cctcacctac 302100 tggggtttat aatttcgaca aatgaatttt ggagaaacat aaacaatagg ttcctaaatt 302160 ttgaattctg gcgcctattc tacctttttt tttttttgga aacttttaat taaataaaag 302220 tgaatacatg acccagtttt cttatttgga aaaaagtgac gcaagttcaa tttgactatc 302280 aaatgcaaat tgaaagataa ttttcatttg gaaaggttca attgataaat atataacaac 302340 aataaaaatg gctaaagtac atttcctagg gttgtcataa cacattaaca taaactgtgt 302400 ggcttaaaaa aattattctc acagttccag aggtgggaag ttcaaaatca aggtgtcagc 302460 agggtcgagc tctttctgaa agctctagag gaggattatt tttgcctctt ccagtttctg 302520 gtggccccag gcattcttca gcattccttg gcttgtggcc gtatcacttg aatctgtgcc 302580 ttcatcttcg cagggggttc ttctctatgt ctctgtgtgg cctctcctct tcttacgaag 302640 acactaatta ttgggtttag ggctcaccct aaattcagga tgatttcatc tgaaggtcct 302700 taactaatta catctgcaaa taccctattt tcaaataagg tcacattctg aggttccaga 302760 ggactttctt aattttgggg tgacaccgct caacttagta cagctgctat tcatgtgaag 302820 tttccgatgt gacagactct tccaagtgat ttgcatatac tttgcataga ctgcctccca 302880 taattcctgt tctactccgt gaccaaggct tattcctcaa tttctagaac cctgcatggt 302940 gagttatttt cagcccacct gcctgtatta tgaagcttct cccctgccct cctgactcct 303000 gctgatgctg caggaaattt caccagtgcg atggctcacc cctcacttcc aggtatcctc 303060 ttggttaaac ccaactcaca ctgactaaga gttcaacttg gcacttactg tctatggaac 303120 aggcattttc aaagttaaaa agttagcttt tgaaagaaca gtgaaagaag tgttcccctt 303180 gggtaggtag atgagacaaa taatgaacac aaccgagagc agcaatattt tatttacaaa 303240 tatttttaat tatgtaaatt tatatgaaat aaaactttta aacaggagat tatgaataat 303300 aatagttgtc atttaatact ttcgttgcct ggggacagtc ctaaaattac taaagtaatg 303360 cttggcggct aggtgaccag agactcatga gaagtactaa tttgatatcc ctttagaggt 303420 aaaggtggaa gactgatacc aagtagacag ggtttggagg cttcctcaag ctgggactta 303480 gtttcccttg tagatttggg atccctgccc ccccattcct ttcctccaca gactcactgt 303540 ggctccccct tcccatgagg tatgaataaa ggtgtgaaga agggatgtgt gatttccatt 303600 caacctgaca ttctgcttaa tgcattcccc tagagggtcg cttgtgatag gacatgacct 303660 accccagatt ctggttctgg gtcatgaggc caatgctctg tgacctggct gcccatgtcc 303720 tcttcatcac ttagctaaag gccacctgga tgccaaatgg tggatcccag tggccatcat 303780 aacatttctt gtccccatcc ctataattga ttgctggaat cagggaaatg gcaggacttc 303840 ctaggactaa aatgtttagg cctttggggt gttggaggtg aatacatcag gttttaaaaa 303900 tttatggcat ttagacacac actgtcagag ggaagaggaa tcttacttgt ctgacctttc 303960 cagcctatca aatattttaa atacttaaac atattttgta tgtgagatgt attctgtatt 304020 cttttttgaa atgagccaga tacattttat ttaatgcatt gattgtttcc ccttaaaaat 304080 gaatcagata aatatctcaa ggagcatata ttgtcttcag ggaaatgcca cacagtgtga 304140 tcagcaccac cgcagaggcc cgggtgaggg gccagtattc agaagaggac acctacctgg 304200 agctctttcc tggggtcgtt tctaatattg tgacatgatg ctggactagg aagacctgga 304260 gtctggttaa tggtgcaaat atttaataac taggatttta agcactttgc tccaagcctt 304320 catttcctta ttgacaaaat gagcacctta gcccattttg ggttgcaatc ataaagttca 304380 aaagactggg tggcttagaa acagcagaca attattcctc actgttttgg gggctggaag 304440 tctgagatca ggttgtcagc agatctgtca tctggggaag ccttgcttcc tgcttcccag 304500 acagtgcctt ctctttgact cctcagatgg cagagagcag agctgaagaa taagctaact 304560 cttgcgtctt ttctaagggc actaatccaa ttcttgaggg tcccaccctc acgacctcac 304620 taccttccaa aggccccacc tcctaataca atcacagtgg gagttaggat ttcaacatat 304680 gaatttttgg ggagcacaaa ctttcagtcc atagcaatga gcaattagaa caatttgaaa 304740 accattaatc taacttccac aacatttgag agtagatgct gggcatccaa atgtgtttct 304800 tgtgacatcg ttacccctaa aaatgttctc ttattacagt ttcaaattca tgttgaatag 304860 gtcattccca acgatatgta tagatagcac tgaacattca ttttttgaga ttgagtattt 304920 attttttgaa acattctata tattttgaat aatcttcttc tgaaatcagt cagttagaga 304980 acatgtaggc agatagtctc aatgaagaag tggatcaaaa atgccatgtg ttttcagaaa 305040 acaagtttct tttgttaaaa ctttgagttc ctatttcttt ttctccatgc tcttttgtgt 305100 attttgcttg gttctttctt tgctttcagc cactgatcta tgcaagtgac attctttttg 305160 atcatcagga ctgcaagtta tcccaaaata atgccttttg ttttagaggc gttgccacat 305220 ctaccaggtc caaaacaaat agaaatttaa atttattcca aatacttgtc ttctactact 305280 ttcagtgcaa tacattttgc tgaatttggt tggatttctt ccaagtcttc ctaaacatca 305340 atatactgaa aaatcattct tccttaagta taatattatt actttattaa agttcatttt 305400 aatacatgta atgacatcac aacttgtaaa atgttgacct taggtcttat atatacttac 305460 gcacttatat gcatttatgt gtgtgtatag accacacaca cacacaaata tacacatata 305520 tgtgatatat taaacatttt aaaattcttg actctgagaa aggcctctat tcttttaata 305580 aggaaataac tttcaattta tgaagtaaac taaaccagaa taaatggtac agacaactat 305640 ttatgaagag cattatgttt aggattcttc tcttaaaata cttaaattta agctttgctg 305700 tttattctcg tgtgtttcaa atatgtatta tctgatgctt actagcacgc actttatttt 305760 atttgtaaac ttactttcca cataggtctt gtttcagaga agcatttaaa tatagtctgt 305820 tactaaaggc tggcataaaa taagtattga aatagaggca attgcagaaa gttctggact 305880 agttatagta atgtgaatgc ttttttattg aaaattttta tgttatctaa tatgcagaaa 305940 acaaatgaac aaaaataaaa ataacaatgg cctgtaaaat gacattcatt agtattttga 306000 tgtataaaaa gacttcccct gtatcaagat tatattgata tgcaactgga ttttcttcta 306060 acacttttat tgttttattt ataacattta gttttgtaat atgcacctgt agtcccagct 306120 actcagaagg atgaaagcag ggtaatcact tgagctcatt aactttgaga catgcctggg 306180 ccacacagcg aaaccccatc tttaaaaaaa aaatacccca aacaaaaaac ctttaaaagt 306240 aatatatatg ggattccttt taataaaata ttttctctca gttgttagtt ggttggctca 306300 atatttgttg gtggagtaat ggcattaaaa acggattgaa gttgatcgaa gagggatcag 306360 ggttgcacag aaaggctggg agggatgggg gagctctttt agggcatttt ggcagaaagc 306420 aaaggagatg cgggacccag tagcctaagc agcaccccct ctcttttgtt catgtttgtt 306480 tattaccgat ctttttctga tttatatttt taaagctctt atatcctagg aagttttgtt 306540 tgttgcctcc ttcactaagc ttcctacaat gtggaagaat taaggccata tttagtgaca 306600 ttagaacaca ggaagcaaat aaaacctgct tctcatcctc cagagattca cagcgcagtg 306660 tgaggagggg catggaggga cgtagatgtg ggtaattaac atcgacagag agattacgct 306720 gtgtgtgaaa atagaatctc tgagtcctgt gggagcggag gggagagagg aattggttct 306780 atctgggaaa tcaatggagg cttcttagag gaattgttgt ttgatctgaa cttttgcctt 306840 cagaatctag acggacctta attaatgttt agtgaatgga ttaatgaata gagtgttttt 306900 ttgctttctg cttttgggtt gtgtgtgcga aggggaggtg agcgggcatc aaatgtagga 306960 ggaacggccc agaagcatga cagttgataa ttagtcattg tgtgttaaga gctcattaat 307020 tctaataaag atattggaga tggatcatac gtgaaaataa agcaccccaa atgcataatg 307080 caactcaata gaaacaaact gctaaaggct atcgacacta acattatagt actatgcaag 307140 taaggacagg ttttttggcc atatttttcc atagcatcta ggaaaaaata gaaacgtgaa 307200 aatatttgtg agtacatggg aaaatgattt tatgttaata aagccattag gtaaaacgag 307260 acacaccagg aatgccctgg gtcttatctg catatagaga ctatgctttc atcttaatga 307320 aggtatctgg tccatatttt cccttttcaa aaatctcagg aattgtcttt ttttcaatta 307380 ataacatcat aatatccctt ctcatcttat aagaaacaga gatacacagg accaacaaca 307440 aaaaacatcc ttgctcttga tctgtccctg attataagtg attttagctg tatttcattt 307500 cactgattct gtttgcaaac aggctttcac acttgttttt aagaaataaa ctccttttct 307560 caaataaaat ttcactggaa atcccaattt ttcttttttt tttctttttc ttttttttga 307620 gatggagtct cgctctgtcg cccaggctgg agtgcagtga cacaatctgg ggtcactgca 307680 agctctgcct cccgggttca cgccattctc ctgcctcagc ctctccgagt agctgggact 307740 acaggcgcct gccaccatgc ccggctaatt ttttgtattt ttagtagaga cgacggcgtt 307800 gcaccatggt ctcaatctcc tgacctcgtg atccgcccgc ctcagcctcc caaagtgctg 307860 ggattaccag cgtgagccac cgcgcccagc catggaaatc ccaatttttc taacaaatct 307920 cagcgatgct ctggtggacc cggtgtggac atctggggtc tgggccctct cggcctcccc 307980 aaccacaagc ttgtcccatg gagaccccta aagcttgtct gtaaaacatg ggactccctt 308040 aagtaatcac tgggctgtgg tcagcgaggt tccatcctag tcccaagttt tgttctatga 308100 aagtctctgt ctgggtttct tttcatcctc taaaggacac gtttttctct tcattttacg 308160 agttgatttt cctttgtgct gtttcatcct ctactacttg acctcatgaa ggaaagacgg 308220 aacccagaga actaggtatt gcccttcatt gtgtctgaga ccccgaataa taaattagag 308280 cagaaatgta tcattgtctt tcttctctcc tccttcccct cccttgtgct ccatgttccc 308340 cagtctcatc aagcaattct acctgagagg ccttaagatc tgatttgaac accacggcct 308400 tgatgacttt attagcaggc ggttcaagga ccacactggg aggaaagaaa aacaaaacac 308460 aacagaaaat taaaataaag taaaataata ccattgctcc agaattcatt gtatggcaaa 308520 cacagaaagc acaatatcaa ggcaaatttt gatttcatac ttaaaagttg ctcgctttta 308580 gttttgggcc aaattctgct tggtgtcaaa atggggaaac cagaattgtt ttcaaaagat 308640 gaaatatttc ccaataataa tttaaaactt ggacatttca cagctttgtg attgttagag 308700 gaaagtactt gggggagtgg cgcattttgg ttgaagccaa cagctccggg tcctacagga 308760 cagcgtgatg ggcctgctta gcttcctgct gtgcttggcg tgctgctgtg cacggggtta 308820 gctttggatt catacagatg ctgtcatctc tttcaactgg aaatgaagga gcactaacac 308880 cccatctctt gatcaaacac gtgacctctg agtggagagg gcagaagggc tctcaggagt 308940 gagtgaccga tgggagagag gctatcccca aattatttgg ctgtcaagca gacctttacc 309000 caactgagtg gcccctgctc tgcctctgtg tcagacaaac actacatcca tccctttact 309060 cattctcttg ctccactgct cactcactca cctaccactt agcatttatt gagcgctctc 309120 tctgagatcc agagatgaat tccacctggg tcccacttca gggccctcca aaaccacatg 309180 gaaggaggag gactacttca tataatgcga aaggtgcttg ggaagcgttg gtttgttggg 309240 gctgctgtaa ggaagtacag ccagtgacag aaatgtattg tcttacagct ctggaggctg 309300 caattctgag atcaaggagt cagcagggct ggttccctct gaggctgaga gagagtcaat 309360 tccaggtctc tcccagcttc tgggagtctt tggtgtttgg tgatttcatc tctgccttca 309420 tcatctcagg gcattctctc tgtgtgtctg tctgtgtcca aatttctcct atttataaag 309480 acaccaggca tataggatta aggacccgtc ctactctact ataattttgt tttgtttaat 309540 tacatctgtg acaaccctat ttccaaataa ggacagaggt actagggatt agtacttaag 309600 catgtgagtt ttttggtggg ggtggggaat ataattccta taaaaggtag cattctctcc 309660 cagtaatttc ttcttgaggc attagatgtc acaaataaac aatgttagtt ttctcagagt 309720 ttagttactc aagagtgctg tccatttgtg gacatgtttg caagaggaga aggcagcacc 309780 gatctatgtc ataaatcagc ctgctgtctg tctgtctctc tctcgaccta cctcccttcc 309840 tcaccacata ttgaataaat tatactgagt gatatgatat ttcagtaggc ctccaggaac 309900 tttgttcagt gaaaagaggg tttgataagt tgttaaacaa taaattaatc aaagtgctca 309960 atgctaaggg actttcatgg gtatctctgt ggcccatgag aatgttctgg aaagccaggg 310020 agagaaaaag atgtttctca agtcatgagc tggagtctga gacctgaaat gggagtagaa 310080 aatcctctgc cttttcatcc ggaaagtttg gaataagtta ggtgttttgc agttctagga 310140 gcatttatta aggggcattt cctaagtgag gcagtcctgt tctggggatg cacaaggagg 310200 caccatgcct ctggccttca aagctgtcac ggctggactt gtttttaaaa ttcgagagct 310260 ttaaatcaag ttcagaaatc attgccaaaa ttttctgtgt cctctttacg catcccaaaa 310320 ctgtatttct gtgtcagccg ttatattatg tccttacaaa aattaataag accaaatctt 310380 caccctgaat tagattagaa tctaccggga ccgggtgcag tggctcacgc ctgtaatccc 310440 tgcactttgg gaggccaagg cgggcggatc acgaggtcag gagatcgaga ccatcctggc 310500 taacatggtg aaaccctgtc tctactaaaa ataaaaaaat aaaaattagc caggcgtggt 310560 ggtgggcgcc tgtagtccca gctactaggg aggctgaggc aggagaatgg cgtgaacccg 310620 ggaggcggag cttgcagtga gccgagatgg cgccactgca ctccagcctg ggggacacag 310680 cgagactccg tctcaaaaaa aaaaaaaaaa aaagactcta ccggtcagct ttggttttca 310740 aaatccattg gtagagtatt ggaaaacctt tgaatcttag atggtttcac atcacctctg 310800 taatgacctg acctctaaat ataaggtcat attctgaggt tcttggggtt aggacttcaa 310860 cataggaatt tagggggtca caactcaacc cttaacagtg tcccagtcgg catcacagga 310920 aatcagtttc cgcttcttct ccaaccataa aatcgaacat gctgatgccc actttcattg 310980 tttttcgcac atttgctggc tgaatgttgg acacttacgt ttattaaagg catgaggttc 311040 accattcaga gatgtgatgt aaagtaacgt ctcaggctca acactgcact gcagtgggtg 311100 tccttgtagg ggcttcttta tttgccttga gaattggcca cagcacttac ctccagcttc 311160 ttgcctataa atacttctca accaagtagg tgtttttttc tcccaaatca tgatccatgt 311220 tgaccttgca aggagacaaa gtcctgcttt aaatactttc aggtgtggtt ggacctagac 311280 atctctcact atctttgaac cagttggtca ccttgctcca tttaggtgta tctgaggtgc 311340 cgcgtctctc tacagtctca caaccaccaa cctttagcat gttatgtatt tatctgcctg 311400 tcattcccac ctgactttga gcttctcaag ggcaaggatt ggctcttatc catcctgtct 311460 cctctgcacg tagcacagtg cttgctacat atctgatact caactaataa tgtacattaa 311520 gaaatgagat gaatatattt ttgaaaaatg tgcttgcata tctacagtta gttgagtctc 311580 tacagtagga atgatgctga taatttattt tttaacttcg acaaacactg tgactcttac 311640 atcctgattg gtaaaggctg aatgaaagtt aaggaaacta aggcttattg agatacaatg 311700 tggcaggcat ttgccaggat ctgaacacac gccatcacat ttaaaccaca ccctaactct 311760 gtttgcattt ttgtctgaca ttatggttga ggatataagt ctagggaaat tatttgctca 311820 agttattata tgttataata aggagaaaat gaacattttg tttttagtgc ttattcacat 311880 gaagcactgt tctaagactt taaatatgta ttatcttatt taattctccc ctacaccttt 311940 aagatagaga gtgtcattgt atccatttta agaatgagga tacttagaca cagggaatgt 312000 aagtaaatat gcagatcaga tagggagcag gtggccagcc agcatgaaaa cctagtgact 312060 tggtatcaaa ggttacagtc ttaactgtga ccacctcttg gggaaccaag tcagacccag 312120 gtatgtctat cagaaaagtc catcctcttg ccccaagctg gaacccccta tttttcttat 312180 tcactactag atgataccac gtaagtttag agattacaga ggtaatattg ggagaaatca 312240 ttacaaccgc ccatgatttg atgtcattct gtactttatt tctaaatcag aggataattg 312300 ataatagatt aaattaaaat aagtaatata gaagattatt ttggggtaat taccttacat 312360 aaaattattg agtaacataa tagattactt tttaaaaata tatcactcta tatcattgcc 312420 ctggatagca agcaagatac ctgctcttca aatgtaaaga atgtttttca aggcagagct 312480 caagaaatat gttcataaaa atgaacactt ggtgataaat gtcatcatcc tgcagagtga 312540 agcaagagtt ctggggacat gcctgtggag tctccaggtc cacatcaagg cggggtacac 312600 acatggatca ccccaagtct accctttgtg caggaagact cccttcagct accctggaga 312660 tgtgcacatt ttctagtcga atttcctatt tttccctttc ttacatacaa gaggaagtaa 312720 aaccttgact tgcttctgaa ctgtcacaaa tgacatttac ttttttccct gtggaaacta 312780 cttgaaataa ttaatatcca agaatataat ctttatgcaa ctactttact cctagagaaa 312840 ttccaaggtt agaaaatgtc aaaaggaatc tgaattgatt ttgccacctg gggtcaaatt 312900 ttctattcta gttatgaaag tcaattttca taaaaaaatt tcacatactc taacctggga 312960 atatcctaat ttcaatgaat aaaaaacata tggctgcctg tttaaatttt gacttttaat 313020 gcagaatggt ggtatttagc ttttaccttc tattttataa aattctgtta ttccatagga 313080 ataaagtaga tgcagattta tcaagtaaat tttaaaatat gtggccattt taaaatgaga 313140 tcatacttgc agcacatcag gtattagtaa cagaagattt atttaaaaga aaatcaaatg 313200 gatttccttt cagggaaacc acttgaagaa gctagaatat tgagagtgat gacatgttcc 313260 aatcacctaa ataggttttg aagcttcatt ttcaaaccta gatggaggaa ggaagagata 313320 gaaaaacaga gggttagatg gaaggatgga tggatggatg gatgggtgga tggatggata 313380 gatgggtggg tgggtgggtg gatggatgga tggatgaatg gatggatgga tggatggaca 313440 gatggatgaa tggatggatg gatggatgga cagatggatg gagggttgga tggatggatg 313500 gatggatgga cagacaggtg gatggatggt tggatggatg gatggatgga tggatgaatg 313560 gatggatgaa tggatggatg gatggacaga tggatggatg gatggctggt tggatggatg 313620 gatggatgga tggacggacg gatggatgga cgatgggtgg atggatggat agatgtttgg 313680 atggggaaat agataggtgg attcatttcc tttaacaatg cttatatgtt ggttttgtgc 313740 atcagatctt gaattaggaa atcagagaaa gaaacaattt tcacatatat cctggaatat 313800 gcaaaatatt ttgtacatat atagagcaat gaaaaggaaa ttattcttac atgcattcac 313860 acatgcctgg attcatcaca cacattggca ggaggtaagg atagttttga ttatttttaa 313920 gccaagacaa tgaggtagcg tttattctct ttacagtatc ctgaaacaat cttaggacct 313980 acagaatccc ttttcactca gattccctgc ttttgctgac taactgcaag tgaaacattt 314040 ttccattgaa cttgtaaagt taattcaatt aagtgacttt attttaaccc acgtctgtcc 314100 aggcttcgga tgactgtgcc atccctcact gaggctgtca cggtggtccc tggggccctg 314160 tgaaatgccc aaaagcacat atgcgcacat gcgcgtgcgt gtgcacacac acacacacac 314220 acacacacac acacacacac acacagagcc ttgtggctgt tttgaagcac cacccccgcc 314280 aaagtcctac ccagggccat tccatttgca ggtttctcta accccaagtt ctctcttctc 314340 caggtcaccc catgctctct ctcccccagg ttaccccagg ctctcttgct ctttcctttg 314400 agtctctgta cttatgtccc ctcatcagga tgcccttggc catcttatat cagcagcatg 314460 cccccatcac ccatgatctt ctttccctgc ttgctttctt gttccggacc actgagctaa 314520 agccctcggc aagaactgtc tgaacactac atataaatca tgacctgcat gagacatttc 314580 tgaccacctt tcctttatgt ttccctatag ctttcattac cgctgcacat accccatgct 314640 tgcttattta tgtgttgttt tttgcttgcc ttccatgtgt ctagaacatt catgttgtct 314700 gctcattcag tgaggcatct cagacaccta gacttgaagt gattctgtca caaaatagtt 314760 cagggaaatc aatctgcaag gaggaaaaag atggatcttt tatttatttt tttaacttga 314820 cgtcagcaac tgtcttatct gatatttatt agtatttcag attcattgtt ctttttttgt 314880 tttccccagt ggtttgaatt ttaaaggaat ttctttgtat aaagtatttt aagcaccctc 314940 ttttatataa agtattaaat cataacattg atttaaagcc atttaatttg tatgaccttt 315000 taagcagccg tgagagcata aaagaagagt gtatcaaagc aaaaagtaag aactcttgag 315060 tcttttgaaa atatttactt tgaacagatt gcagctcctt aaatgatgag gctttggaat 315120 ctgggaggtg gtcagacccc agctctgcct acttgaggcc acccacatgt cgctggaccc 315180 actgtgtgtc ctccccaagc ccagcacctc atcttcaaag tgacacccac aatagacagc 315240 tgtgcagagc attgagtggg atgctggatg cagaacctgc caaatatcac tggttgctga 315300 tttatcagtt taattgaatt tctgctgcaa aagaaggaaa ggaatggggg caagacctgc 315360 attttccatg acaagatttg tgttttgatg gcagggaatg tgctgcatgc cacccacctg 315420 tgatgcaacc actcaggaat ggggaccaaa cctttttgcc catctctcct ccttccttaa 315480 ggctgagctg agagctctgg gttggaattt cctgttggaa tctgctctgt tcttccttca 315540 cccttgccct gagcaagctc actgagcagc tgcctctctg agccgggagc tgggcccagt 315600 ggtggaaata ctgacgtggt ccctgcccat cagtctgcag tgcagagggg aaacacaccc 315660 aaggctactg tgggaccctg gggtgtgctg ggtgctggag aaggaccgtg caggagcttg 315720 ggcatgtggc tataagaaag gacaggtaaa cggagacagg ggtgaatgaa gaatgagaca 315780 ggtgtggtgg ctggaacggt gtacccagca gagggaacct gatcccagag ggtgcataat 315840 gcgcctgaga ccggcagcag ccttggggag agggaggcag attccaggca aaaggcaagc 315900 tgcaggtgcc agcaggaact gtaaaccacc atgtcctgca agccttggtg gttttggctc 315960 tgctggtgtt gacgagacgc caagaaggag attgtagctg gagagagaca atcacgtttt 316020 cagtgtaaac tcttattctg cctgaggtgt ggaaaatagt cgtgggaacg aggctgacca 316080 acaccagaag cagggcactc cttgtacata gttcagtcga ggggagtcta gggaagcctg 316140 aatggatggt tggatggatg gatggatgga tggatggatg gatggatgga tggttgaatg 316200 gatggatgga tggatggatg gatggatgga tggacaggca gggctgagag atgttatggc 316260 aaagaggcat gtagctttga tggacaccac ggatgtggac agagtgaaga aaacagggag 316320 gatgttgtga ctcccttatc gagcgatggg gtgggtggtg gaaactgtgg ctctaggagg 316380 ggcctgagga aatgtgggtt tagggtggag aaagggtggt ttggtattcc ataggtggat 316440 tctgaagtgt cctgggattt ccaagtgaga ggaaaactgt ctctatagat gagaaaaaat 316500 attttcttag agcattttaa tgtcaaatag aacttatttt aggttatttg tcattttaaa 316560 ttagccaagc acttgagtct ttctataggg tggatatgca attgctcaga attgtcttat 316620 catgacacag aatgggatag agcatttact ttcagtgtaa actcagttca agacaccacc 316680 tgttatcaga gctcccaaaa gacaacttgt agacaaccag tcaactgaag ggctgaaaat 316740 tattttttgt gaatatttaa aaactttttt taacctgtag ttttgtttat caacaaaagt 316800 caaattgaga aaagagagct tatcaaatct gtatgtgact taaacaataa atggagtttc 316860 agttcctggg taagaaaatt attctaaaaa gaaaaccaaa tcaggaggag tcaatggtgt 316920 ttctttgtac tgagtttgtg tctgtcgtac aatgaccatg gaatggtgca cttggtttgg 316980 acaagtcact tctgggggca gtgtggagct acagcagaga gcaactgaga tgtgagccca 317040 gggcaattgt ataaggtgtt cagttcttat tatttcatca tgttaaggca tctcttgaaa 317100 taaacagcac ccttagagtt aaagcaatat atctgtgaca tagaaattgt ttctccaaag 317160 tattgctggg gtcaatggga aataagcaac gacaagcctg ttcccataaa ctttattgcc 317220 tcctgtaact gactttctaa gtaaataaag gttcttagtt ttgcttttct tgcagaaagg 317280 aaagaaagag ggatacccga gggatagata gccaagagtt atgctaattc tctgatattt 317340 tataataaaa gagatttcat ctaaaaagaa aaggaggttc tgaaggtggt tatgtacatt 317400 cttccaaact caaagtcacg tctggaacat tcttatatgg aaagagctaa aaatacttaa 317460 aaatttacct tgaacatttc tcatccaatc atattatggt ccaggcaggt gctgatatga 317520 gggacatgat ggtgcaatat cctttgacaa gcagaaggga ctgtgagtct ctgaggatgg 317580 gatgcagacc tttgatctgc tccataccaa ctatgaagga ggtccatgtg cttttgaaac 317640 acattgtaag gatccaagac tttgcagtta aggttgctcc taataaacac aagctaatag 317700 tgcaaatatg attcctgtgc aaaggtaaaa ctatttaacg gccactaaga aacagcaccc 317760 tgttttgtaa tagtaacatg taaaaccaat ggcagatgca tgccagcgcc tcttagcact 317820 ggagagcaca gtgatcactg ccttactgga gaaacttccc agaggggagt gccatggaat 317880 gctttgagga agaggagggg ctaaaaatgg aaagcctagg ccagaagcag tggcttatgt 317940 ctgtaatttt gggaggctga ggagggcgga tcacgaggtc aggagatcga gaccatcctg 318000 gctaatacag tgaaatccca tctctactaa aaatacaaaa aaattagccg ggggtggtgg 318060 cacgcgcctg tagtcccagc tactcaggag gctgaggcag gagaattgat tgaacccagg 318120 aggcagaggt tgcagtgagc cgagattgca ccactgcact ccagcctggg cgacagagtg 318180 agactccatc tcaaaaaaaa aaaaaaaaaa aaaaagtgga aagcctggac attgccaaag 318240 acaaaatgtg tctttcatcc tgtccatgag gaggctctga ctgctgctca cctcgctggc 318300 tgctgctctg tcttttatcc tctaggattc tgaaagcaga gacaatgact tagcaggtga 318360 gttactgagg ccaactgagc aaaaacaaag gacagatgga gtacctggca gtggaggagt 318420 agggacgtat aaagccatcc ctcaaggctt gtgaccttaa ggaatagacc agttagttag 318480 aaagacaaga tgcacttgta caaaatttac caacagtatg agactatggt gctagcaaat 318540 gtcacagaca tgacgattga agtagaagaa attcttggct caaggaagag caatatccag 318600 tatttactgg aaggaatatt ttaaattagt gctgttctag aaaattcagg gcaatggcta 318660 tgcattattc tatttataaa acatttctac acactctatg tataataatg tataacaaaa 318720 taacaggcca gtaattacta taatggagta taatatagta tattatgaga actggaggcc 318780 aagttctcag aggaagccac tttattcctt aagttaatat gatgaatctc gctttgtgtc 318840 tcttatgcct tatttgagcc acacagagga ggaaagagga gaatcccaac acatagtaga 318900 ttcttgaatt tcaccattaa atatgggtca ggactgtggc tatggctgtg cttatgtcat 318960 ggagagcttt gtgaaattaa atcaatgatg atttatgaag tcatcatcag aacatggtag 319020 aaatactatg gttttgggca ctgaaccacc ccagtgttga aaggtttgct ttttggcttt 319080 gaggtttaaa aaggagctgt gatattttga gacacagaga tgatggatgg cagccagacc 319140 aggttacctt acatggcaga actcctggag atgactagtg gcatgattag agcatccgct 319200 cctgtttcca cagctatgag gcgggtggtc ttcagataaa aggagagccg catacagggt 319260 ttctgtctca ggatttcacc cacggttctt cctccagagg caagggtgag cttcatgttt 319320 cctttgcacc agtagcaatg acagcagaaa caggcactgc aatataatta tactggattt 319380 attccagggt gtatctgtta tttattactg tataacaaac tacttcaaaa cttagtggct 319440 tagaacaatg gctatttgtc tagttcatga ttgtgtgaac tggcaattta ggctgagctc 319500 agttgggtgg ttcttctgct gtcagctagg ttcagtcatg agtttatgag cagctgcctg 319560 tcagagaggt ggctcttctc ctggggttgg ttgccagcta tgtgttagga agataaggag 319620 aactggatca ttgtttcctg ttgtccagca ggcaacccta gactacctca catggtagct 319680 cagtaggttt cagagagaga gtgtgcagaa gcttagactc agtgctggta cacagcaact 319740 tctttcacat tctgtgggcc aatgtgaaat acaaagatgc cccatgtggc tagagtggag 319800 aagaagacta tgggacttga taggaggagt tgtgaagatc attgtaaagg ctatgatact 319860 tggagacatg gaggattatg gctatttttg gcatctacca tacatggggt agattttgtc 319920 tgaaggcagt gtggctggaa gcatttagga agtgagagct tcacctgtat gtccatatag 319980 ggacactatc aggaatagga aggtcagaga aaaatggagc ttaacagagc aaatgcccta 320040 aagagacaca gaggccagag ccacctgctt ggaaagatca gagggatgga acagcagggc 320100 agggacttta agccacacca ggcagtgcaa atgctgctaa ctttgcaggg gctcaggaac 320160 acaggccagg gaagcacctt gacctcctgg ctccaaagct ctgagcatca ttcttagaaa 320220 tagctcccct gccagcatat tttgtaccac tgagaaagtg actcaggatc aaatccagag 320280 ctctgttttt tttttcttaa ttaactaatt gattttgaca aataaaagtg ctctgtattt 320340 aaattatata acacaatgtt ttgatatatg tatatactgt gaactgagtg ccacaatcaa 320400 gctaactaat gtattcaggc ctctgttgaa gtgccctaat ggttctcttc aaactgctgc 320460 aaaaatctga taagcaaagt tcctggccag cccgaagtta cctcgagggc tctcattatc 320520 tccctgaatc ccaccccccg gcctcaccta ccatgccatc tctcacccca tcctcttttg 320580 gcagatgtcc ttgtcttcta cacacctgaa aaggggaagg catccagttt catattctca 320640 ttgcagcacc tgtgtcagtt aaggcttgga tggagccctc tgagtagcct tcaccccctt 320700 ctccctgaat aagccaaata aaagtgggtt tcatttgagg gagtgacatg tccctgaaag 320760 gcttggcctt gtggtaagtc acaaacaagg catgaacaat attcccacct tctcctctct 320820 gctaagtact tgccctgaaa aaaactaagt tctgcaaagt gctcagaggg tttaggtgtg 320880 aaccacccag ctggaggcag agttatagct ctgcctctgg gggccagctc cagctgggag 320940 gttgatggga gcctctgacg ctgggctccc cgagaagcaa gatcctagac aagaatttga 321000 gtgtaaggaa cttctttcag aggcaggccc agaaagtatc ctaggaaatt ggggaacgga 321060 catgggaaag aaaagaagtc agtagagagg gtgttgtcca gcagtttatt ggtgtgggaa 321120 actggggttc agtcccacct ggggcccccg agagatttgg tacagtacac ttcaaatgat 321180 catgtctgag ataccaggag cccaccttat ctatggctga ggtctgttca tgctctgtct 321240 tgtttgctgg ccaagagaag gttctcagat ggaaggccac aggggttttc agtaggagcc 321300 ctcttggctg agactgaaat gagggtacct caaaacatta agtgaatttt ctgagaccat 321360 atagctggga gctgagtctg tctaatttta aagtccttgt tctttaacag gagaaaagag 321420 aaaatggtga caaataagta gtttcttgga tccaagacat tgagagtggc tatttcctcc 321480 ttgcacagaa ggcttcttga tggaaaccaa attactctga aaagttacta gttttaatat 321540 cttagcaaat catttgatac attcacggaa gtgtttatca gcaatgtata attgttcttc 321600 tcacttaaag aatgtttgtt tcatgacatt ggagatctgt aacacaaaga cccactttgt 321660 atgatgaacc cccgtggtgt agctgcttac agggccctca cacacactct tttggtccct 321720 gaccacatct gttttaacct ggttctgact ataccactgt ccactgctag acagaaaaga 321780 ggaagacatg cctcattctc caaaaactgg aggaatggca tcattttcaa gtttagtttt 321840 tgttgtttcc aagtatattt atgtaatgct gtattatatg tatatacttg ccatgaatta 321900 aatacgtcac aaataaaatc cacttttggg actcaacagt atgtaaaaac acaagtagta 321960 tgaacagatt tatttataaa gttatgatga gcctttctga aatctttcta gcatatcact 322020 ggtgtaaatg tcatgggaat tgaaaataat gtatttgaat ttcacagtct tctgtgaatg 322080 gatttttttt tttttttttt ttttgagact gagtctcact ctgttgccca ggctggaatg 322140 cagtggcatg accttggctc actgcaacct ccacctcccg ggttcaagca attctcctgc 322200 ctcagtctcc tgagtagctg ggattatagg tgcatgccac cacgcctggc taatttttgt 322260 attttttagt agagacaggg tttcaccatg ttggtcaggc ttgtcttgaa ctcctgacct 322320 catgatccgc ccacctcgtc ctcccaaaat gctgggatta cagctatgag ccaccacacc 322380 tggccctgtg aattttttaa tactgcattt cccaaaaaga atttgtcttt ctctactttt 322440 taaaaaaagt tttccctgag tctattataa agtcattctt gaccagaaaa ctcaagcaaa 322500 aaaagaatga attagttgac ttgtccagat tctatgttta gcagacatgt gtaccaagag 322560 tttgtattga ttgttaatac atgataacac agaaagcgct gaaaaatctt aactctatgt 322620 aaagtgttta tatatgtata taagcactta agattttatg taatataact ttttctattc 322680 aaccttttaa ggaatatcta atattttaaa ttactttatc aagcaaagaa aaaggacaag 322740 tttaaaaata aaaacataga aaaggaaaaa aaagagaatt atcctgtggt gttctctcat 322800 taacgaaaaa taaaggtttc ggaaaatctg ttaattttcc aaattttaga tttttatgtg 322860 ctattagatt ggaaaatgac agattaaaat tttgaaaaat ttgttcatga aaattctaac 322920 tttaagttgc tcatgatcta aattttctta gctctcatga gatctggttg tttaaaataa 322980 ataaataaat aaattttctt aaggacccaa ctgccactaa gattgtttaa atggtagcta 323040 ctggcatttt ttgttataag ccgaatttct ttcatcaaat caagctcaca cattcactca 323100 agttcttaag atactgttga aatgggaaaa gtccctttgt ccccctctca gggtgtgtga 323160 tgggggtgtg gctcgtgttt tcggtgcctc actgctcaaa ctttcaggag agggcataca 323220 gacaggcagg ctgtggtgac tccgacccca tggcagcgtc tagaggtgaa tgtttacagc 323280 tcctgaggcc ccagtgtgtg tgtgtgtgtg tgtttgtgtg ttactgtgtg ctctattggt 323340 ttagcatgtg caggtggctt gtgcgtatca gatcaattag actcctgcct tatcacaaag 323400 acagagggct tttctgtatc ccaggatttc ttgctttgct gtaccagaag aatcagatca 323460 cacctgggct tggagaatga gtgcaaggtt ttgttgagtg gaagaagctc tcagcagatg 323520 ggggagccag aagggagatg gagtggtaag gtggttttcc cctggagttg ggccgctcag 323580 ccaccagggc tctcctccct ctgcctcccc gaaactctgc ggcattcacc ggtcaatggc 323640 ctgctggcct gctggcttct gtcggtgtgc tcttaggccg gtgcattcct cccgaagtcc 323700 agccacttgt gtctttttcc actgatgtgt tcctctcaac atccagctgc ttgtgtgcgt 323760 gcccgctaga gtctcggggt ttttataggc acaggatggg ggcatggcag gccagggtgg 323820 tcttgggaat tgcaatattt gggcacaaaa acagaaatgt ctgccttcac ctaggtccgt 323880 gggcacaggc ctgggagtag agccctagtc agggaccaca acctcctcta cccaacactt 323940 ccctgcccgc ttctgtatca ctattccttc attaattaga aagtatgcat tttttaaaat 324000 tatgaagtgt ctaggtgtct gccagcatta ctcaatagga aactccaata gaggagtaaa 324060 gttatttctc caaggtcaac aaaattaata aatacaaagc cttcatcacc agagccgtgg 324120 tgaagagctc tttgcactat gtgtaagcga aacatgaaat caacaattta tttaccttca 324180 gtgtaaattg ttcattgaat gtcattatgt tgtcgattat tgattcctac cgcatgtgac 324240 aattacatgt gcttctgcct tccctgccct gagtaccagg ctgctttcaa ctctgggcag 324300 caaggtggca agatagagtt gatggagttg cgaatggaaa caggaagatt tggcatctga 324360 atctcgaaaa ctcttgacga aaattctctt tagatacaga gatttgataa cttcttaaag 324420 cgaagtttgt tttgctcatg acgatcacac ctatcagctg atcaattctg tttccctttc 324480 aaggaaaaaa atatgtatcc tgcatcagca aggattcatg aactaaagga ctcacagagt 324540 agaactctcc acttttgaaa ctgaggagcc aaggcccaaa gagaaaacgt gacctagatt 324600 tagtcattat ttattgtttt aaagggggga caatcaaatt aatgaaggca gttaaaaata 324660 cattgcattc ttattaaata cattttgtag gatttatgcc tgatgatcat gaacatcaaa 324720 tctgactttc ctgttgagca aaatgaacta taatcaagtg gaacgaattg ctttgctatt 324780 atcccttgtt gtggatttgt gtcagcacat ggtaactgag ctgaaatggg ctttgtttgc 324840 ttagctcttc tcctaaggag aacaacacca tttactctga gtttgtactg ggtttctgtc 324900 tactaactgc ttatattggc cttactttaa taaagatttc tatctcactc cttaatacgg 324960 cacatgccaa tgggaaacac ataccttatg cctagctttg ttctatagca gagtttctca 325020 acctcaaccc attgacattt tgggcaaaat aattcttttt ctcggggagg gagtggcgaa 325080 ctgtcctatg catttttaaa tatatttttt aaaaagttta attgacacac aattattgta 325140 cctatttatg gggcacaacg taatgttttg aaacgtgtat acgttgttta atgatcaaat 325200 caggataatt agcatatcca tcacctcaga catttatcat ttctttctgg ggaacataca 325260 aaatcctcta tgacagctat tttgagatgt gcgtaccttg ttgttgactg tagttgccag 325320 actgtgcaac agaacgccag cacttctcct ttctcatcgt taactttgta cccattgacc 325380 ctccactccc catctcccta ttcctactcc ttaccccatt ctattcacta tttttataag 325440 attgacttta gatttcacat atgagtgaaa acgtggtatt tgaggggtta atattcagaa 325500 tacataagga actcaaacag gtcaacagca aaaagacagc aaaaaaaatt aaaaagaaga 325560 tatacaaatg gacaacaggt atatgaaaac attctcagca tcactaatca tcagataaat 325620 gcaaatccaa accacaatga ggtatcacct cacttcagtt agaatggcta ttatccaaaa 325680 gacataataa gataacaagg gttgctgagg atgtggagaa aggaaaccct tacacactgt 325740 gggtgggaat aaaaattagt aaagccatta cggaaaaaag tatagcggtt tctcaaaaaa 325800 ctaaaagtgg acctaccata tgatccagta ctttcactcc tgagtgtaca tccaaaggaa 325860 atgtcctgtg tattttaaga tgtttagcat tatccctggc ctccacccac tagatgtcag 325920 taccacccac cctctcactc ccagttgtga caacaaagaa tgtctccagg cattaccaaa 325980 tgtcatcaga aggtcaaaaa tgaccccggt tgagaaacac tgttctacat acagtaggga 326040 ttcttgaatt attgtaaaac acagaaagag tgcttttaag ttgtttgaaa ttttatttta 326100 ttagaatcta tgaaagtatt tttaaatttt tagcaataca taatatttgt acatacttac 326160 agggtacatg tgatattttt aagcaaacaa gcaaaggcca tttaagctca attctcatgt 326220 gctaactcaa atacaatgat ttgcaattcc ttatatacac actacatcac actacatata 326280 ttttctattt atttatttat ttttagagag agagagtctt gttctgtcac ccaggctgga 326340 gtgcagtggc acaatctcgg ctcactgcaa cctccacctt ccaggttcaa gcgattctcc 326400 tgcctcagcc tcctgagtag ctgggactac aggcacacac caccatgccc ggctaatttt 326460 tttattttta atagagatgg ggtttcacca tgttggccag gctggtctcg aactcctgat 326520 ctcgtgatct gcccgcctcg gcctcccaaa gtgctgggat tacaggtgtg agccaccgtg 326580 cccggccaca cactacataa cttttcatcc attctcacgt tagtgtttgt gttttatttc 326640 ctcctcaaga atctataaaa tataaaaata tttaatgcat ttaaattgtt gacagcaatc 326700 tttgattttg aaatactttc atgaaaagca tattttctgg aagataatag cattgcattg 326760 aatcctgctc ctcttaactg acttgctata attattgcag agaattattt tctcttgaag 326820 aaagatggta tttaaagtaa ggtataacta ctgacctgtg tgcctctaga atgagagcaa 326880 gtaagtatac caccaaaatt caactggaag tttgtagttt tatggctcct agaatttatt 326940 ctaggagcaa tttattccac tattgcaagc taatctactt cacatataat ttagggcaaa 327000 tgaattatgt cattaaggaa acatattcat ttagagttgt taaatgcctt ctaatagatg 327060 caagatctga aataatataa atatgtgctt atattaagag tcaggggcaa caaattttag 327120 agtctagaat gttataagaa ggaaggtcat gtgttttatg atttgattta aactacccta 327180 gtgattcaag ttacctagaa ccaataatca acagggtatt ttatatgtgt atggacacac 327240 acacacacgc atacacacac acagagagag agagagagtg agagagacag agacttaaag 327300 aaattggccc acacaattgt cgagctggca tgtctgtaat ctgtagggca aagcaagagg 327360 ctggaagctc aagaatgatt tctattttta tgttatggtc ttgagtcaca atttctcctc 327420 tgggtgtctt agtctatttg ggctgtcaca gcaaaaatac cataaactgg gtggcttgta 327480 aacaatagaa atttcttcct cacactactg gaggctgaaa aatccaagaa taaggcacca 327540 gcacatccag tatctgttga ggacccactc cctggttcat agacagcgcc ttcttgcttt 327600 atcctcagat ggccaaaggg gcaaggggtc tctctcaggt gtcttttaag agtgcacaat 327660 accgttcatg agggctctca aatccccacc tcctaatacc attaccttgt gggtaagaat 327720 ttcaacacaa attttgggca gatacaataa ttcagaccat agcactgaga ctttttttca 327780 taaggttctc aattgactgg attgtagatg ttaaccatat ctacaaaaca ccttcacagc 327840 aatacccaga ttcgtgtttg atgaaataac tgggtattat tacagcctag ccaagctcac 327900 acataacact caccgtcata tatttacaca tgcctaggaa gagtaaaata aagggctatc 327960 tggacatttt cttgaattac cagattcata aatacagtta tgtaccacat agtgacattt 328020 cagtcaacat cggactacat gtatgacagt agtcccataa gattataata ccgcatttta 328080 ttgtaccact tttatgcttg gtatatttag aaatgaagta cttaacatta tgttccaatt 328140 acctacaata tttatgcagt aacatgctgt atgggttagt agcttaggag caataggcta 328200 cacagtaaag cctaggtgtg tagtaggtta tgccatctag gtttgcatta agcacactct 328260 gtggtgtttg catgataatg aaattgccta atgacatact tatcagaaca tatcccactg 328320 ttaagccatg cacagttgta tcatgatgga tggatgttct tcctataact caatgaagta 328380 aaattttaag gttttaggtg gtgtgtgtgt atatatatat acatatatat acatacacac 328440 acatacacat atatatacac atatatacat gtatatatgt gtgtgtatgt atatatatgt 328500 gtgtgtatgt atatatgtgt gtgtgtatat gtgtgtgtat gtatatatgt gtgtgtgtat 328560 atgtgtgtgt acatatatat atataaaata tatattatat atattatata tataatatat 328620 aatatatata taaaatatat attatatata ttatatataa tatataatat atataattta 328680 tataatatat ataatatata taatatatat tacataatat atataatata ttatatatat 328740 attatatata tatatgggca aactgcattg aaaatatgtg cagatggtct gcgaggctct 328800 ttgacagact ggctgccaca tgtcagcaga tgactgggct tgtgcctcac ccagcaagac 328860 aggacgcatc tcaggccttc agggtctctt gcaaatggtc agaactcaag ggtccattgg 328920 aatgcacaca cagattccta ttgaattgga atatcggcta ttcactctgt gtttaggaat 328980 actcagtatc gaggttcact aatacccatc atggaggttc tatgtgccct ccttggtccc 329040 ctgtgtccct ggacccaagg tgtgcccacc ctctgcatga agcacccatg tctctgtgaa 329100 ccaagagtct gcagaggcca gaaaagcatg ggacccagag gttggcattt gggctaaagc 329160 tcatactcag agccatgtgc agggccaaac aggtgatgaa aaatgagagc actgggctgg 329220 acccaggctg aactcaggaa caggcagcag caacaaattt ccagtaatga gagtctgcca 329280 gggacacagc actgtcactt tcctcctgcc acctcaagag ttaagcctag ggacagctgc 329340 aggtctcagt gcccacagca gcaccccaga actacattcc aaagagggga tcagagagga 329400 agcactttgg ttttttacac agctcctatt tatgtgttct tatgacatgc actgtcctgt 329460 tttcatggtt ttgttgaagt tccaggtaga atgggctaaa tgcacattaa gactgaaaac 329520 agaatgttaa atggcatcat agacatatta gaaaaggagg gcttagagat tacctgagtc 329580 aaccttgtgt gaaaactgag aaaaatgaga ccctaacaat gttatatggt aggctgcaaa 329640 ggctggcttt gggtcccaga agaaaatatg cgtgtctgtg tgtgtgtgtg tgtgtgtgtg 329700 tgtgtgtgtt gcttgtgtgt gtgtatagat gtgtgtatgt gggtatatgt gtgtgtgtat 329760 atatatatgt atatacagag agagtatata aggtgaatat gtacatttgc atttatatat 329820 aaatatataa atacacaaat ataaatatat aaggtatata tatacacaca taaggtgtgt 329880 gtgtggatgc atatatatgt gtgcatatat atgtatatgc agagagagcg tatatgaggt 329940 gaataggtac atttgtattt atatgtaaat atataaggta tatatatata cacataaggt 330000 atgtgtgggg gtatatatgt gagtgcatat atatgtaaca tatgtatata tatacacaga 330060 gtatataagg tatatatata tatacatatg ttagtatgta aggtatatat atggtgtata 330120 tatatgtata tatataatat atgtatattt acagagagta aggtgaatat gtatatataa 330180 atatataagg tatatgtgtg tgtgtgtata tatatatata tatatggtgt gtgtgtgcgc 330240 atgtgtgtgt atccggattt gctactgtct aatgaataaa caagatccag atttgaaaca 330300 caatagtgta tatgaatgtt atcagaaaaa gcccatcaaa tttctcccac actggggcac 330360 tgcagagtcc ttcccttctc gaatgttctc cctggcactt gtgtttctct ccttcctgac 330420 ctctgcctag tcgcagatag agatgcattt tgacagaacc gggaagagtt gttctatttc 330480 catggcaacg tcaattcaca ttctgcaggt acattggccg ccactgccta aatgaaggct 330540 cctcaaggct ctgtgtgttg ccgtgcctgg ccaaaaataa ctgggcatgc caccgttcct 330600 cacagcccca tggagagagg cattaaactg actggatgcc aactgtcaac tctgttcctg 330660 tcttcctgct aaagaggaag aaacaggaac tgccagtgtt ttgggggagg ggagccaggg 330720 aggctgctac attgtttcca tggtctgaga aacatcgcat ttcctctgtt gaatggaaca 330780 tgaaatacat tcttacttgt tcaccccagg ggcaccagat aatttgtatt tcagcagaag 330840 tattataatt acatagttta gagttagaat taattagcat ttggggaagt agtgataaaa 330900 ccaagcagtt attaaaaaaa ttaattttaa tagaggtcag tttggagaga gtgcttggtt 330960 ttcttttgaa agatttgtgt gtgtgtgtgt gtatggtggg ggagataaaa gaataaaatt 331020 attaaatgat cctttaatca gtctgaaatg tgaactacct tatcattaga cgctaccact 331080 ggatgttaaa atccaaatta gtggcacaca tgcagaacat atttcaaaat tagtcaagag 331140 ttaggtgaat ctttgagggt tatctatgaa aaaaaaagaa agttttgtag agtcctttaa 331200 aaagtatatc atgttcccaa gaatgtgggt cataacaacc ttcttgacgt taaacatagt 331260 caagaatgat ttcatgtatt atactagaca catgagatac ttcataataa ttaaatattg 331320 tttgaagaat aatttttgaa atcagttaac attgcctacg agtgcgctga gtgtgaagct 331380 ctcctgggag ggcttgtgca cccgggaata aagttgaatc tttgccctca tgaggctttt 331440 actttgtttt gagtgaggag tcagaaaaga ctgcaatttt taagagtatt tttaccttca 331500 attggagttt tacaacactc ctctaagttc ttaaaatcaa agaccatcac agttaaattt 331560 taattttttt ctgaaattga tcaccgttcc gtggttgtat aaaagactgt ccttgttctc 331620 agaagataat gttgaaacct ttggggagaa agagacatca tgtatgcagt ttactctcca 331680 attgttcagc agtaacaata agtgttttca ttagaatgag agaaagggaa agcagtggag 331740 aaaatgaggc aacttgttat caagtggtga gtggaagtgg aaggtatgct acagttactg 331800 tactattcgt ataactgttc cttcgtttat atattttttt caaaacaata agttaatgta 331860 gtctatagct ttaggcaaaa actctttttc aaggaaaagg agcagtgtgc aaaagttatt 331920 tttatttttt cttaaatgaa ttcgcagtct ttttgaaaat ctggaacgtc aacacttgta 331980 aatgtatact tctttagttt tcagattata gtaggaatta ccctactaat attctgaaat 332040 aagaagtagc ctttactgat gtaccaatat ttttaagcag tgccagtttc taagtaatct 332100 tttcttaact tcgcttctga aaatttgaaa aatgtccttt cgtcacaagc tataggctgc 332160 attagtttag cttttccttt tccttccaag acaacaccct tgccgcagtt tggggccaga 332220 atgatcagct gacccattcc acatctttat actctaaatc aaagttgttc cctttaaaga 332280 gctcattgga gaggaatatg tgggatttga taagctccgt tgatggttta ataattatga 332340 atgtttaaca gacattatac atttatccca catttactag tataagagcg aaaataagga 332400 atgaaagcaa attgttctgc agggtccatt tgtgcatgct attatgcccc ataaagaaaa 332460 aaaatctttc ataaaggatc gttagttttt tcatcttatt tacaccatta gatgttgctg 332520 cagaacatta gaatatgcac tggtgcaacg tgaatagtct gtctgctatt tattgcataa 332580 tccattttat gcaatgtcaa aaaggaaaac aaccaaaaat acagggttta ttttaaatta 332640 ggagttaagc tctgactttc tgatgtgcta agttgaagcc tggagcattt tctcgctaat 332700 ccagtgtgag tttctaacag tgagccctgt tttaagagga aaaagggtga tgtagtccaa 332760 ttaataagat ggccttgttc attttccctg ggatgatgaa gcattggatg gctccctggc 332820 tcagtgaaaa cagggtggaa aaacgttgat ccaggaattg taaattgagc atgcagggct 332880 ctgcaacagc tttcctatac ttctttggga ataaggagta gggttcacca tacctgtcca 332940 gttttctttg cacttgccac tgtttctctt aaattgtttt gggaggttgc tttcattttg 333000 gcacattttt gacgaaaaat gtgtgccttc aagttcatgc ccaggttgtc tgtcctgatc 333060 acacaaatgg ccttggaggt tccttatgaa ttctgtatgc aatctgtcac tgcattgctt 333120 atgtagcagt tttgagtgca aagccttgaa aattaatgaa gtgcctttct gttttctgtc 333180 ccaatctgtg atctggtgcc tggagggtat tttgactatt tttgacttca cttgtttttg 333240 ttgttgttgt tgttgttaca tacagttttt ttatttttaa attctctctc taatatgtta 333300 ttttgctttt attctgtcca ttcattcaac accatgttga catagtttgg atatttgtcc 333360 ctacaaatct catattgaaa tttggcccct aatgttgaag gtggggcata gtggaaggtg 333420 tttgggtcat ggggaaagat tcctcatgta tagcttggtg ccgtccctgt gataatgagc 333480 gagttctttt tctactagtt tatgcaagag ctggctattt aagagagcct gacacttcct 333540 gccatcactc ttgctccttc tctggttggg tgacccacct gctccctttt caccttccac 333600 catgatttga agctccctga ggcactcacc agaagcagat gttggtgcca tgcttcttgt 333660 acaacctaca gaaccataag ccaaatcaat cttttctttg taaattatcc agcctcatgt 333720 attcccttac agcagcacca aacagactaa gacatatatg catagttgtg ttcttagatt 333780 ttgttgttgt tgttcccaag atagattttc ctttcttttt ttcttttctg ttctccatgt 333840 ctcttcattc atattacaga tgaggcacag gacctgggct gaagtatgta cggggtaggt 333900 aggttatgtt ctctcctctt tctatgcagt cgatgtaaga atcccagcac tttgggaggc 333960 caaggcgggc ggattacccg aggtcgggag ttcaagacca gcctgaccaa catggagaaa 334020 caccgtctct actaaaaata caacaaatta gcagggcgtg gtggcacgtg cctgtaatac 334080 cagctacacg ggaggctgag gtaggagaat cgcttgaata cgggaggcgg aggttgcggt 334140 gagcagagat tgcaccattg cactccagcc tgggcaacaa gagtgaaact ctgtctcaaa 334200 aaataaataa ataaataaaa ataaaaatta gtggaggaaa tgggcaagcg tcgaagctga 334260 gaattttcta tggtcccttc cctcccctgc agttctggga atggccacta gggacgcagt 334320 tgtgccgtta atgggtctcg ggggaggcct tgcccaggtg tgaacgaggg aggtcagagc 334380 actgttactc ttatggcgca taactataca gtactataac tttactatga taacttcact 334440 gagcaacggt acaaatcgac aaatggacaa cagtttctat cattgattaa tcaaataatc 334500 agaagtcaat aatctgctaa gaatattctg acctctactg gcccttggca atagatggag 334560 acagaacaat gccgcaaacg tgaagacagc ctcccactct ctcctctccc acttctccta 334620 caggctttga ggatcaccac gtttcgctcc ttcattcaca tgtctctgac attttagagt 334680 ccagaacatc acaagatacc cataatttcc aatgacgtga agtaatagag ataagattta 334740 gtaggagagt aaacctacct ctgtccttgc tgttgtatcc ccagtgtgca gtggggtgac 334800 ttcccagagt aggtgtgaag tcagtgtttg tggaataaca gatatgaaag aaaatagact 334860 cagttttgta agaaagaaca aggttcactc aggataagat gggcaaggga atttcttctt 334920 atgtgtaatc gctgaatcat gcataattgg aagggaaaga tcactgctac gttaatttcc 334980 tcctgcaaac acacacactc tcttcttgca aaacagtgta acctatctcc cttgcctttc 335040 tcattggaga aagctttttg catgcaagtg tttcccccaa aagcaagacc tcaaatagaa 335100 tacttttttt tttttttttt tttgagacag agtctcactc tgtcgcccag gctggagtgc 335160 agtggcgcga tctcggctca ctgcaagctc cagctcccgg attcgcgcca ttctcctgcc 335220 tcagcctccc tagtagctgg gactacaggc gcctgccacc acgcccggct aattttttgt 335280 atttttaata gagacggggt ttcactgggt tagccagaat ggtctcgatc tcctgacctc 335340 atgatccacc cgcctcggcc tcccaaagtg ctgggattac aggcgtgagc caccgcgccc 335400 ggccgagaat actttttgta ggttggtgaa agagtgactt atgtataggc agaggtgcaa 335460 agagagtgtt ttactggaag tgcagggttg taactttact ctataaagaa ttataaaatt 335520 tgtagactca tgaatattag aactgaaaac aacattagtg attctagttt catcttttcc 335580 atgtttgtag tcaaggaaac cttttctttg gagaaatgat aaagttaacc acaatcacat 335640 tcattttgaa tatttttgtt attaagtaac atatgctaaa tttatgacat ttgttttcaa 335700 taagagctgt gacatggata ctctaatcaa gaaattaatg taataactta cattaagctg 335760 aatttcttgt atttaaaatt ttatctatat gtgaatatat ttttaatgtc actttttatc 335820 agccctgtta acttgagggc tgtggcaaaa ttcctatttc tttatctata aaataaggat 335880 agtatcatat ctgttctgct ttcctctttt ctcaaaagta actgagaaaa tgtgaaagca 335940 ttttatgaac tataaagcaa cataccatga agagaattaa acaaatgaat ataattttat 336000 tattctccca aataaatcca acctttatta ttaacacata tgtgaacagt gcaaaaacaa 336060 gtctgataca ttttttaaag gtcaggaatt ttgtagaatt tttaaactat aaaagaaaca 336120 tgacatgatt ttctcaaaca taaatttctt gcttttattc taatacgtaa ataagcacaa 336180 tactgataac ctatgggtca gatctggcag gcttccaaat taacccatct ggcagaagtc 336240 ttgtgattca tggcaacatg cggtccctgg gtagggtctt atcaggagtt ctccaattgt 336300 tggcatactg tttactatgt aacttacaga cactgaaaag gatcctgatt tgtttcagaa 336360 tgggaagaaa gtctggctga tggtcttgca catggacact ttaacctgta tgttgccatc 336420 tgtagccaat gattgtaact tctgtaatgt accctccaat gaaaaaggac agctctggtg 336480 tgaggagttc tcttccttct aaactttctt atagaggcct tccaactcct agctgactct 336540 ggaacacacc caacttctgt tgacttcctg agtcaatctt cacatttagt tttcaataaa 336600 cctttgtcaa tcgtcacgtt tgatttcgaa caaatgttta tcaaaccatt atcaaacctc 336660 aacagtctta attttggtca acaatactaa cattttgagc aacttattat ttaaaaattg 336720 atgtatatta attcctaaaa ggtggactta ttacaatgta acaaccagtc atatctaaaa 336780 tgccactaga aaattcctca taaaaatgct atctctgttg aattaataaa ttttcccttc 336840 aatttcatag tctttttttt agaagcctag cctatatagt gtttatttct atattggacc 336900 tggctatact cattagtgat tttatagtgc tttctttgtt atttatttta gagtgctttg 336960 gggggggaca attttagatt ctttttttat gagatggagt ctcgctctgt caccaggctg 337020 gagtgcagtg gggcgatctc agctgactgc aaacctgtgc ctcctgggtt caagtgattc 337080 tcctgcctca gcctcctgag tagctgggac tacagttgtg tgccaccacg cctggctaat 337140 tttttgtata tttagtagag acggggtttc actgtgttag ccaggatgat ctccatctct 337200 tgaactcgtg atccgcctgc ctcggcctcc caaaatgctg ggattatagc catgagccac 337260 ctcacccagc ctagattctt ttagagaaag atcaaagcat gtgtaataaa gtttgctttc 337320 tgttctagtt ttgtttggtt tcagaatgca tgtataaaat ttttataact tcacagagta 337380 ggatggcatt gtgcttgggc ctcgttcctg ttttttaatg tgattacata tgagttcttt 337440 catagaaatt ttactagcta gtggtcactg tgtgtgaaat gctgcttatt gactgggtcc 337500 atgtctgtgt ctggttttcc tcatcattct gaacccactg catattggca tttgccagtg 337560 gggtgaaagt actgtacagg ccttttggaa aaccaggctc aggccccagg ctctgagtga 337620 gaggaacaat ggggagctgt catcccctca cctcctccca gtgaaaaata gaaaatcaaa 337680 tctcctttgg ccacttggca aggatctagc cgttatttct ccagtgtaaa agaaaagggt 337740 cttggaaaaa gaccctttgc taatcaatat acgagtagga aagattagag aggtttgaca 337800 tcttgggcat taggattcac tgcctgaact ccttttgaat tctactttgt tttattttct 337860 tggaatttat ggctgcaaat gactgtgctc ttggaaactg agggcctgat gaaagttctt 337920 cccttgcttg tgtaacaagt gacactcacg gactgacatc aacttccaaa aatatgcaga 337980 attttagaga aaaaaaccaa ctgcacaagt tgcaattttg tacaaagagg aaacaacaat 338040 aactttgtgt tttaggtatt agggagctca tccatgttca ggccatttta ccaaatttaa 338100 aatttttaat aaccaaaatt ttaccttaga aatgtagcat tttgccatca ttccttttgt 338160 caaaatgttg tttttctggc tggacacaat ggctcatgcc tgtaatccca gcactttggg 338220 aggctaggca ggaggattac ttgaggccag aagtttgaga ccagcctggg caacataaag 338280 agaccttgtc tctataaaaa agtaaaaaaa aaaaaaaaaa aaaaaaaaaa tatatatata 338340 tatatatata tatatatata tatatatata tatatatatt tgccgggtgt ggtggtttgc 338400 acctgtggtc tgagtgactc aagaggctga ggtaggtggt tcccttgagc ccaggagttt 338460 gaggctactg agagcgatga ctgcaccgct gcattccagt ctggtcgaca gggcaagact 338520 ctatctttaa ataataataa tgatgataac aacaacagca atactaattt taaaatgttg 338580 tttgtctcca tatttaaatg ccaaactgtt tagttaacat ttttaatttg atttcaatta 338640 acctatgctt gggatctttt taccattaca atttgcattt gaaatacata atagagttat 338700 tctaataatc caaaaacaga cttttgagat cttttccctt ctctttttga tttataaata 338760 gcatattgat tcccatttaa agtgtgggtg cagtgtggct gtcagcatat tccattttag 338820 taatttcatt attgatttat ttcttttcta aaagttacaa aagcaatggt gatttgcttt 338880 cgcaaataga agtgactcag aatggtaaat actcacagtt catggtttct tccctgcctg 338940 acagtgtgag tcagaaatta aataaatcag tgttgaaatt cctagaatgg aatctgctgg 339000 gacccacact gcgtccatac tccatcccct tctctacaac cagattaaac atactctctc 339060 catgtagggt ggctccactt aggaaaataa aagtgactca actgtaccca tttttccaca 339120 ggtacattta gcaaataccg gtgggttttg gttacaaagg tccagggatt ggtgctctag 339180 gagagcagtt caggaaaagg gtctgtatgc aggagtggag gggcgagggg gtacagagaa 339240 agctgctctg tgataggctg tccagagggc agctccaaca gtctcctgtg aatgtaagtt 339300 atttttattt atacatttat ttttttgaga cagagtcttg ctgtgctctg tcacccaggc 339360 tgtagtgcag tggcatgatc actgcaacct ccaccttcca ggctcaagag atcctcctgc 339420 ctcagcctcc cgagtagctg ggactacagg tgcacaacac cgtgcccagc taacttttgt 339480 gttttttgta gagaggggtt tcaccatgtt ccccaggctg gtctcaaact cctgagctcg 339540 agtgatccgc ccacctcagc ctcctaaagt gcagagatta caggtgtgag tcaccacatc 339600 cagctgtaga tgcaagttat attcacaaat gtaagatgga cattagagta cgtgatttgc 339660 ctgctataga aatacagcag tgtgtatgta aagttgtaaa tgccgtattt tttacccgta 339720 agacaaatag aagagctata tgctttaatg atgcatagga ctattttctg aaatctgcta 339780 ctggtgttga atagttgcgg ctgttttttt aaatttattt ttattattat tatttttgag 339840 atgtattcta gctctgccac ccaggctgga gtacagtgac gtgatctcgg ctcactgcaa 339900 cctctgcctc cagggtttaa gcaattctcc tgcctcagct tcccgagtag ctgggattac 339960 aggtgtgtgc caccatgcct ggctaatttt tgtattttta gtagagatgg gttttcacca 340020 tgttggtcag gctggtctct aactcctcac cttgcgatct gcctgcctcg gcctcccaca 340080 gtgctgggat tacaggcgtg agccgctggg cctggccaag ttgtggctgt tattttaaca 340140 tagaaagttt ttttccaatc aaagtgtaac ttctctgata atatgctttg tatttgtgat 340200 ttatgtttta gtaatagtag ggcaaaatat ttttttcctc ttttgattac cactagacca 340260 atattttttg tattatattt aaagttgata ttttggtaac acaataagat aaaatatatc 340320 tttttccctt tataaccacc aatctgatgt ttccaatgta acagttttaa aaacgcttct 340380 tcctggatat acctagtgat tcctgaattc tcttactgca gcctaacgac tgttactcgc 340440 tctttgcttt aaataatctt gacacatagt cctcatcaca gatccacatt ttctttggcc 340500 atatatacaa actcgacagt gtggtgttgg aaatgtgaaa gggctgctaa ctctcctgaa 340560 tctggggtca ctggttatca aataccattt aagcacttta tatctgaatt aagccgattt 340620 tgtttgagcc acttgatttt tccaatgaag caagaaggag caaataagtg gtaaaaacaa 340680 ccttggcttg ttttactttt cctccgtgaa gtcagtgagt ccggggctcc cactggtatt 340740 tttcatgttc atcatggacg tcccaggcag tagcacattc tgagaaatgg catctaacct 340800 ttcaaattga agattttatt tgctagaata ttcactcttt attgcttatc tcaaaatcag 340860 gtgggatgag tgtcattact gtcccctcgt gcatgggctt cagatcagtt gatagctaag 340920 cctagccgat gctcattcat ctttgagatt aacagagtag cttataaaat gcgttacaca 340980 tttttgaaat gcaagcatga agtgcgttag taaaaaagtt ccttcagtaa atctttaaga 341040 atctggaaaa aagcacaagt cagtttaaga gtatcatatc cgtggttcac tttgcagcag 341100 tgactttata tcttgttttg tgtgtgtgtg gttctttgca tcattttgaa cattttcttg 341160 aatgaaaatg agtcagatac agctactttg cttgtctcct gtagacacac actttgatta 341220 atagagttgt tggcgaagtg ttaaaagtca agaatgttgt tatcaccaca cacagaggga 341280 ctggatatgg ggagtgtagt gggattttaa atgagaagca ctgcatatca caatcataga 341340 gtaactcctc gagtgatttt acgtgatgag ccgagcttcc ccaaagagta atttaattgg 341400 catatttgaa gctagaagtt tctgacagcc accctgtacc ttagcaacag cctgttctct 341460 tagtaagagt ccctgtaaac aggtgggaaa attaaggcac tccaaatgtt tatcaagtgt 341520 aggacattca ttatagtatt taccttttag agatatgtct gaaattccat aagacagttt 341580 aagcaagcca ccagctgttg taaagggact gagaaagctc tgactagtag acttcttctt 341640 agaatttacc agactttttt tttttctcag aatgctgtga atcataagac tttcactaaa 341700 ctttcctatt cttatcaaac agcaaataaa ctggctaaaa ataactggaa gaaatctttt 341760 agcatgtaac aatactcaac tacatggaaa taactctatc ctgttttcct ttgtaaaact 341820 gcaacaacaa aaaaattgtc attttcaaac tgtgctgaat ctctggcagt ttttgaaccc 341880 agctgcctgt cacggtttga gtctctgtac tgtgtgagtg atgataggct aaatccactt 341940 ccactgattt ttctaactca ttctcaaagt tgtcttaagg ctttcccatt atttccaatt 342000 acctgtgaaa aatgggcaac caggaggtgg gacacagtac cacaaaacca agtcattgat 342060 aggctcttac cttccacctg gtggtggcct cagtcttcct ttgaatcttc tgagtaacat 342120 agcaccagag aaccatataa acagcccttg atttccagcc tcagaggcag acatgagagc 342180 tggtatgaca gtcaactctt actatatctt atctgtatac tatacaaata agggaataaa 342240 tacaaataaa aagatttttt tctgataata aagtaatgca tgtttccact ggatagtctt 342300 aaaactgcaa atagttactg agaaaataaa taaaatgcac ttgcagtttc acccccagag 342360 atccataatc aggtcctctg tattgaacca ttcaaggggg agtccaggtt ccattggaac 342420 acaggatgga tagcggcccc agaagttgca cagctcgggt cttaaacagc tgttaacatc 342480 ttgtgtcacg cattatttga gcctttcgca tcgcctatgt agtttttctg ttgttcttct 342540 ttttttattt tgctttctaa aacgagtgtc atgccatgct gacaggttaa agcttgttgt 342600 atcctgtata ttttaatgta atgcccgcta accacagtat tccacatcga gaattctgtt 342660 ctcagtgaca ggtggactgt tctcccgagg gagggctgag gcaggaggaa gtactcagac 342720 ttagagaagg catggagaac agggaaggca gggacagctg tgtgccccgt ggccatcacc 342780 attgctggga cctgattctt gatgccctcc tggctgagga gtcggccaac atccctggta 342840 cagacttggt gttattgagt gataaacaaa tcctcttcct cctctctcct cgccccactc 342900 ttttcttcct cttttctctt cttttctcct cccctcttct ttcctcttct cttctctttc 342960 ctttccttca atgttctaag cctcagactg ttcatttcta gagctggcca gatagaacag 343020 tgagtcacgg tgagatattg tgtcccatgg atttgttcta ccagaaacgt ttatgagcca 343080 ctgttgggga gctctggtgc tcttttgaaa tatccaatag catctttctg atgaaagcct 343140 ggaagagagg ttccactagt cagtgaacta gcagaaatga ccaactacaa tgataaccca 343200 tgaccatcaa ttcacagtgg ctgtaaatca gtgccaattc agacctgaat taccaggtca 343260 aatacggttc caagttgcac agtgaagata ctatccagcc aaaactaaaa ccaaaaccaa 343320 atcaaacaaa tacatgaaaa tcagagctag atcttaatct ttgtggcttg agaaatccag 343380 agaaaatagg accctgggta agccctgaaa ttaaagagac gaatgttaat gacttaaaga 343440 tttgtgttcc agatcttcag tgtatttttg tttgagagtt cttgtagcta cctgaggtaa 343500 ggtaacccac tgaaaatcag cggatgtgca gcgtgaagtt ggcatctgac agctccttga 343560 tagcactgcc acctgctcac ttgctcattc tagctacaac agttggtggg agaaacatgt 343620 gctagtcttg ttataagtgc atgttaataa agttttctct gataatgcag gaaagctggg 343680 gacagaggta gctagagttt gtttttcaaa gataacattt ctagtctggt cagatgcatc 343740 cataagaggg ggaataaaca gtgtaggctg atactcatct ggtactaata tcctcttggt 343800 cgaagcatat caggcggtga gtgaatacag ggcaatgctc gaagaagact tgaagcatgg 343860 gagcctcagc tccaaggtcg gtggagcgct ctttgaattt agccctgcaa cccatcagca 343920 gtgtggcctt tggcagatca ctctccaaac cctggtttct tcttctgtaa aagtagcata 343980 atagatattc ttaatgcgta acgttgggaa gtaggaagta aagagaacat atgcaagtga 344040 ctttgtagca gatatttcct taaaggaatg ctatggttct aattgtcagc atcactgtcg 344100 caaatgagac gttcttaacc tgctgtgtgc cgtagagctc tctggcaaac tcatggagcc 344160 catggaactc tcctcaggat agttttgtta aataaaaaaa attatacata atattataaa 344220 ggaaatcatt tagcaaatta ttactaatat atatgttagg cagaattatg actccccaaa 344280 aatgcctgtg gcttagttgc cagacctgtg aatatgttat gtcctatggc aaggggaaat 344340 taaaggtgga gatagaatta agtttgctac tcagctgtcc ttgacataag aaaattattg 344400 tggattatct gggtgagtcc aatgtcatga caagagtcct taaaagtaga aggaagagac 344460 gggagaaccc gtgtcagagt gatgcaatgg gaaactcgat gggccattgc tggctttgaa 344520 gatggaagga gaccatgaac cgaggggttt gggcagcctc tagacattgg aaaaaataag 344580 aaaatagatt ctccccttga gcctgtagaa agaagacggc ctgccaaccc cttgctttta 344640 gcccagcttg acccattttg gatttatggc ctacagaact atagataata ccttggtatt 344700 cttttatgtc atcaagtttg tggcgatttg ttacagcagc aatagtaaac taatacagtt 344760 atcaaattag ataaaatcca tgatgtatga tatgttcttc ttgattaatt tattaaatga 344820 cacactagat ttgtgtccat agcaaatttt aagaagttat tagtgtcaat aaaaatgtat 344880 agagagctat atctgaaatg tgattttgaa aatattagta atttttattg atgatgaagt 344940 cacagtacta atactactgt ggtttgttgc ctatattaat aattttaaaa catgataaat 345000 ttcagttaga ggttagtgaa aaatagaaca aatgttttcc tatacccagc ttcagggagc 345060 ttcctgaatt ttatgcatag agggtatgca ggccccagat taagagtccc tggtttagat 345120 atatgaaaga atgagaaacc ttctaagttc ttcaagatat atacaattca aaagcaaaat 345180 tagaaaatca ctgcagccgg aaagaacatt aataatccat tagccggcgc tgtggctcac 345240 gcctataatc ccagcacttt gggaggccaa ggtgggggtg gatcacctga ggtcgggagt 345300 tccggaccag cctgaccaac atggtgaaac cctgtctcta ctaaaaatac aaaaattagc 345360 tgggcatggt ggtgcatgcc tgtaatctca gctactctgg aggctgagac aggagaatcg 345420 cttgaacccg ggaggcggag gttgctgtga gcagagatcg tgccattgca cttcagcctg 345480 ggcaacaaga gcaaaactcc atctcaaaac aaaaaataaa agaatacgaa gcttaatgcc 345540 tttaaaaatt tattctcatg agaaaagagg cagctcatgg atgacctcag tgaaatcagt 345600 acattctctg tggagacagt ctttatatat cacaatgaat aaaagtaggg agcataattt 345660 ttaaaaatgg aggactcaag acacagattg aaaaggggag cacaaatata aagctcacag 345720 gaataatact aaatataaca cacctgggta gaaacgcatc atttcctcta gtgtttggga 345780 cagaagtaat aacaatactt caaatatgta tttgaagaat atatatttta atatacaaag 345840 aggtgaggtt gtcacataaa atagaggatg cccagttcaa tttgaattcc tgataaacaa 345900 aacataatat ttagtgtgag tatattccaa atattgtgtg gagcatactt atcctaaaaa 345960 ttatgcatta tgtaactaac atttagattg aaatggtgtc ctgtattagc taaatatggt 346020 aaccctgctg agaagagact actaattcta cctttaggct gtatgaagta atatttgcag 346080 taatagatat tgtttggagt atctctgcaa tgaaattctc tttgagcttg ctctctttaa 346140 aaagagaagc ctcgtgctgc atacctacca tattgcctct ccaagcccac tctttccctg 346200 tcttcaccct gctctgagcc ccaggaggct ggctgcctca atgggctccc aggtcatggg 346260 cttcctacca ggttccacaa tgggaggcat cagcaggaga ctatagggca gaagagcagt 346320 atcgttagag agttgatttt gtttcacctg ctccttccca ttcaggttgc tctgaaacca 346380 ctcctgccca ctaaccctcc atgcctaggg aagatgacag ttttgagctg ctcttagccc 346440 ctgggtactg cactggcttt gtaaattgcc cctttattaa tgattgagct tgaaggtgcc 346500 atctcttccc ttctggagct ttaatatgct gaagaatatg atgtagatct ccaaggtcaa 346560 gagtaccgtc tgcatccatg aagctgtgaa ttagaaaaag aaaagtaaga tttggaaaga 346620 aaatagttaa gttgacattc aatagtgagg tcttgctggt cacttaatct ctcttttaaa 346680 acagatattt attcctggaa ggtttctgga aaaattaata gaagcaggag tcttaatcag 346740 ttgaaagaca taaagacata gactacagaa ataagcagtt tattactaga atgtctatgt 346800 tactcataaa acaagacata aatcctgtat ttatgaaata tatgtattta aagggctttc 346860 ttcagaaaac ttaaaaaaca aaatatttag aaactatttc ataaatattt aggaaaaagg 346920 caaaaagaag caaatcatgt gttgtcctga gacttttttc ctgcaatctc ccttttctcc 346980 tcctccctcc cagtactgct gaagttttct tcctaaagaa gggtactcag ccgggcgcag 347040 tggctcacgc ctgacgcctg taatctcagc actttgggag accgaggcag gtggatcgtg 347100 aggtcaggag atcgagacca tcctagccaa catggtgaaa ccctgtctct actaaaaata 347160 caaaaattag ccaggtgtgg tggtgggtgt ctgtagtccc agctactcag gaggctgagg 347220 caagagaatc acttgaaccc aggaggcaaa gattgcagtg agccgagatc gcatcactac 347280 actccatcct gggtgacaga gtgagacact gtctccaaaa gaaaaagaaa aagaaaaaaa 347340 gaagggtgct cagatcttca cctccagcac agacacttgg atgacttcct tctatgcatc 347400 tgagaagttt tcaaaaaata tttgctaaat ttaattgcat ttctgcttct ttaacccaac 347460 tgtcttagat atggtttgga aaagagcaag agaaaagtaa agttaaattc cctaattatt 347520 tcttaaactt tccccagaaa cttaatgggc acgttggatc atagtttgtc ccacatagta 347580 aatgagacac atgcgttgct ggtgagtgcc ttcttaaata agaacagaga tctttcatct 347640 agaggctggc acagattgga aggttctggc tgctatcatc ctatatgtag tagagttttg 347700 gtttttttgt ttgctttaat ctgaatgtct gattgaggta ttcaaagagc aagagagaaa 347760 cctgtgaaga gatggactat ttgtgtcaga actgtttaat cttgtggcta ggatcacttg 347820 tattgttgag ctagattcct caatagctgt ctagatattt gacatatggt gttttactct 347880 attgtggtat atgaccacat aaacagataa aatagtagta atcttttcaa tcttttatag 347940 tctgcaagta ttcatacact tatttcaaag tagtctgttt ctagcttagg taaatttaga 348000 tgatttcatt gaatactgta ttaaaaacct gcttcattcc agttaatttt tttcaggaat 348060 tattactcat actacaaggc attatttata gctccagctc tcttacatga taaagaatga 348120 gctgcgtatt acattgctat aatgagaaat tctcttgtgt ttaaattaat ctcccttctt 348180 agcattgaga aattctgtgg attctaaaat tctatttgag aattgtaaga atgttttatt 348240 actctcttat aatatgtacc atattttttc tctcatatat ctgtcagtga tgggtatata 348300 tatatatata tatatatata tatatatata tacacaccca tatatatata tacacccata 348360 tatatatata tatatataca cacacccata tatatataca cccatatata tatatctata 348420 tatatatata tatatatata tatatgggta tatatataca cacacactat atatatatat 348480 atacatagtg catatataca tattatatat atatacacat actgtatata tattcatgtt 348540 tacataggta tatgtgaaat acatgtgctt ataaatcctg aacaatgcca ggcagctgtt 348600 tttataatct tgctggttta tacagaagtc agtttctacc acctttcttc caatcctagg 348660 gaagttgtct ctaaaacacc catctacagc agaaagggaa gcccatgggc cagccactgt 348720 gtggtttttt atacgcattg ctttgtttag tcctcacagc agtcttgcag agcaggtgtg 348780 gcgtattccc atttttagat aatcaaactg aggctcactg aaatacagtg agctctttaa 348840 ggttactcag ctcgtaatgg tgggtcattg ttgccttcat atacaattga caatagtaat 348900 tcctcctggc aacaaaatga gatatgtcct gaactctcat tgtgaaggag gcactgtgcc 348960 aaacatttaa gcagcccaat gacacagagt tattattccc gttttataaa tgaggaaaac 349020 cgagacacag aaaggttatg acatgtgcag attttgaaac ccagatctaa tgccaaaatc 349080 catactctta acactttact atgcaaccta ccatgtgcta gactttgatg agtctgttgg 349140 attatactcg aaatccagta cttcatattt cataatttta gtggtttcaa aatccacgtt 349200 attttgacca attccaacat agcagttctc atagctggaa atacaagtta gaaatcagct 349260 tccatttagt gatgcaaaac tctgcaaagg caaatgtatg caagctgatc tttatgaaaa 349320 gcaatcccaa ttaactttat tttttaaaca atttatttgt atattgacaa ataaatgtat 349380 atatatttat tgtgtacaac aggatgtttt cttatatgta tacattgggg aatggctaaa 349440 ttgagctaat taacctatgc attactgaat atacttattt ttatgctcag aacacttcaa 349500 atttactcta agggcttttc aggaatacaa tatgttgtta ttaattgcag tcaccgtgtt 349560 gtaggataga tttcttgaac ttattctttc tgtctgactg aaattttgtc gtctttgacc 349620 aacatctccc caactcccca cccctgcccc cacccctgga aaccaccatt ctactcacta 349680 cttctatgaa tttaattctt ttagatttca catatgagat caagcagtgt ttgtcatttg 349740 tgtctggctt attttactta acataatgtc cttcaagctt agccatgttt caaatgacag 349800 aatttccttt tttataaagc tgaatattat ttacttgtgt aaattttctt tattcttctg 349860 ttgacactta ggttgattct aatttttgtc tattgtgaat aatgctgcaa tgaacatgga 349920 ggtggagata tctcttcgat acgctgattt aattcacagc ctttggatat agatccaaca 349980 gtggaattac tggataatat ggtagttcta tttttgattt tttgaagaac ctctatactg 350040 tttccaaaaa tggctgtacc agtgtaaatt tccaccaata gagtactagg gttctctttg 350100 atacacatcc tcaccaatac ttattatctt ttgtcttttt gataacagcc atctgataag 350160 tgtgaggtga catctcattg tggttttaat ttccattttg ctgatgatta atgatgttga 350220 gcattttttc atgtatcgat tggccttttg aatgtcctat tttgagaaat gtctattcag 350280 gttctttggc cattttttaa ttaggctatt tgtttctttg ctattgagct gtttgcattc 350340 cttatatctt ttagatatta atcccttatc agacatatgg cttgaaaata tattctctta 350400 ttccataggt tctctttgct gattgtcttc attgctgtgc agaagctttt taagttgata 350460 taatcctagt tgtctacgtt tgttgcctgt gcttttaggg tcacatacta aattcattgc 350520 caagatcaat attatggagc ctttcccctg tatttacttc aagtcttatg tttaagtgtt 350580 taatccattt tgagttgatt tttgtatatg gtgtgagata agggtctaat ttcattcttc 350640 tgcatgtgga tattgttttc ccagaaccat ttatttaaga ttgttctttc ctcaatgtgt 350700 gttcctggca cctttgttga aaatctattg actgtaaatg tgtggatttg tttctgggct 350760 ctttattctg tattctgtgc aactggtctg tgtgtctgtt tctatgccag taccatctgt 350820 tttggttact gtagctttgt atatattttg gaggcaagta gtgtgatgct tccaacttgt 350880 tcttttgctc aagattgctt tggctatttg ggggtcttat ggggtttcat atacatttta 350940 tgctaatttt tttctatttc tttgaaaaat gccattttga tagggagtgc attgaatttg 351000 tagatcactt tgggtaatat ggacatctta acaacattaa ttattccaat ccataaacat 351060 agaatatttt tcaatttgta ttttcttaaa tttcttttaa caatgtcgta gtttttagtg 351120 tacagatttt tcacttcctt ggttaaactt attcctagat attttactat tttttggcag 351180 ctgtaaaaaa tgagactatt ttcttgataa cttttttgga tagttcattg ttagagtata 351240 aatattctac tactttttat gtgttgattt tgtattctgt aatttttttg tatttatcta 351300 ttagttctaa tagttttatg gtggagtatt tagaattttc tacataaaag atatgtagcc 351360 tgcaaacagt gacaatttaa cttctttttt ttccaatttg gatgttttta attcctttct 351420 ttttcctaat ttctccagtt aggacttcca gagaagtaga acagaaagga caagagtggg 351480 catagttatt ttcttcctga tattagagga aaactttcaa tttttcatca ttgtgtacaa 351540 tgttagcttt gggtttgtca catatgccct ttattgtatt gagcaacatt ctttctatac 351600 ctaatttgtt gagaatttta tcatgaaata attttgaatt ttctcaaaag ccttttctgc 351660 atctattgag atgcacgtgg ttttcccctt cattgtggta atgtggtgca tcccatgtat 351720 tgatttgcat gtattgaacc attcttccat tctagggacc aatcgtactg atcaaggtga 351780 atagcctttg tagtgcgctg ttgaatttgg tttgctagga tacgggcctg caattttctt 351840 agagtgttct tgtctggctt tggtatcagg gtaatgctga ccttgttaaa tgagttgcaa 351900 gcttcacctc ttagactttt taaaataatt tggggaagat taggattagt tcttcaatat 351960 ttcatagaat ttatcaatga agccatcagg tcctggattt ttccttgatt agagtctttt 352020 tactattgac tcaatcttgt tactcatctc tgatctattc agattgttat attcatgatt 352080 cagtcttggt aagttgtatg tgtctagata tttatctgtt tttttatgtt atccagtttg 352140 ttggtgtata actgttcata ttagcttttt ataatccttc gtatttctgt tgtatcaggt 352200 gtaatgtttc tccttttatt tctgattttg tcttcttttt ttcttagtct agctaacgat 352260 ttgttggttc tatttttgaa aaaaaaaaac ccaactttag ttttgttgat cttttctatt 352320 gtttttctag ttctatttta tttgtgtttg tactgacctt tattatttcc tcccttctac 352380 caattatggg cttagtttgt tctccttttt cttgttcctt gaagtgtaac tttaggttat 352440 ttgaaatcat cttttttttt taatttaaaa gtttttttgt taaaaacttc tttattagaa 352500 ctacttttgc tacatcctat aagttttggc acactgtctc tgttttcatt agtctcaatg 352560 atattttagt acttaaaatt tagacgtaaa aaatgaccta ttaatttctt ctttgaccca 352620 ttgatcattc aggaacatgt ttaatttcca tgtatgtgtg aatcttccaa aatttctcct 352680 gttattgatt tctagtttca taccattgtg gttggaaaag atacctgatg tgatttcaat 352740 ctccctagat ttgttaagac ttatggcctt tcagtctatg catgtcctta aatctgaagt 352800 gactgtctta caagcagcac atagttgggt catgttgtgt tctttttaaa tccacttatc 352860 cactctttgt ctttttgttg taaaatttaa tccatttaca ttcaaggtaa ttgtaaatag 352920 gtaaggactt attagtgtca ctttgttact ggctttctgg ttgttttgta gatcctttgt 352980 ttctttcttc ctctcttgct gtcttccttt gtgattaggt gattttgttt agtggtgtgc 353040 tttgatcctt tactttttat ctttgtgtgt ctactatagg tttttgcttt atgattacca 353100 tgaggattac ataggtggct tatatttata acaggctatt ttaagctact aatgacataa 353160 ctttaattgc atacaaaggc tacactttca cttcgcccaa cagtttatat atatatgtat 353220 atatatgtat atattttttt tttttttttt gagatggagt tttgctcttg ttgcccaagc 353280 tggagtgcaa tggcacgatc ttgactcact gcaacctttg cctctcgggt tcaagtgatt 353340 ctcctgcctc agcttcccga gtagctggga ttacaggcac gtgccaccat gcccagctaa 353400 ttttttgtat ttttagtaga aacagggttt caccatgtta gccaggctgg tctcgaactc 353460 ctgacctcag gggatccacc tgcctcggcc tcctaaagtg ctgggattac aggtgtgagc 353520 caccatgccc agccagtttt ctatttttga tgtcacaatt tggatctttt aatattgcat 353580 atttcttaac aaattgttgt agctaatatt atttttaatg gttttgtctt tgaaccttca 353640 tactaaagat ataagcaatt tacatactac cattacagta ttagagtata cttaatttga 353700 ccatttactt acttagactg agttttaact ttcatatatt ttcgtgttgt ttattaatgt 353760 tctttcagcc tgtagagctc cctttagtgt ttcttgtaaa aggggtctgc tggtgatgaa 353820 ctacttcagc tttatgtttt cctgggacaa tttttattct tcctttattt ctcctaataa 353880 taagctaata tttaaaaatg taaaattttg acattaaaaa tataagtgtt ggcaagagta 353940 aaagtataga gattttgtat acaattaaag ttatgtcctt ttctgaagga caggtttgtt 354000 gaattggcag ttttttcttt cagcattctg catgtatcat cccacctcct cctggtttgt 354060 aaggtttctt ctgaggaatc tgctgctagc tttattggaa cccctttatt tttgattcac 354120 ttattttctc ttgctgtttt caggctcctc tctttgtctt tgatttttga tagtttgatt 354180 atagcatgtc ttggtgtagt cttgcttgca ttgaatctga ttgaaaattt tgacttttct 354240 gtacctgtat atttatacct ttccctagat ttggaaagtt ttatactatt agttttttaa 354300 gtaagtgttc tacctcttag tcttcctctt ctttgcctca aactcctgta atgcaaagat 354360 ttgctttctt gaattggtca tataattcca tgtatacttt cttcaaattt tctcattctt 354420 tctttttttc tgttctaatt atataatttc ttctttaagt tcacagattc tttcttctgc 354480 cttatcaggt ctactgttga tgacctttat tgcatttttc tgctcctcga ttgtattttc 354540 tagctccaga atttgctttt aaaaaaaaat gtcaatctca ctgctaaatt tctaatattg 354600 atcatttatt gtttcctgat ctcagtgaat tgtttctctg tattttttga agagttctga 354660 ggtttcttaa aaattttttg aattatttgt gagaaagatc ataaatttct agttccttta 354720 gagttttatt ttatttcttt ggtcttggaa tctgctctgg gagtgtggtg ggaagtcagc 354780 ctgttctcaa ttagttcttt tttcttattt ttatataact ggctaccaat gacctatatt 354840 caaatagaaa gcaagccaat ttcttaattt aagtggaact tatcctcatt atctataatc 354900 tatacctaat aacacatgca ttataaagta gaatttatca aaggctctga agcactagaa 354960 taggattttt tttttctaaa gcaatggaaa aatcacttga tttatttgaa agatatttat 355020 tggttactta ttatactctg gtcattattc taggtgtctt agatatttga gtgaacataa 355080 cagacaaaag ttttccttta tgggatttct gttgtgggaa gaagggtact acatcaaacc 355140 taataaatat gtaaattaca tagtatgatc aaatgttatg tgtagcatgt gtgaaagaaa 355200 tgagaccccc gggaaggggg gttgggagtg atggcatagg ggttggcaat agtcagtggg 355260 ggcaaaatgc ttcaaacagg gcttgctgag aaagtggcat ccgaggaaat gcttaaagga 355320 agggaagttg ctggtgaaat gtatttagag gaagagcttt tcaggcagag agagaagcta 355380 ggcaaaggtc ttagggcagg agtgtgacta gcatgttgca gaaacagcac aaaggccagt 355440 gtgcctgggt tgaatgaatt gggtgtgggg gtgtttatag aaggagggta ggtaggacag 355500 agaggaaatg ggagacaggt tacctggggt attgcagccc ttggaatacc cttgaatggt 355560 acagggtact tttgcatgga tttgaacaga gaatctaatt tctgttttag caactgcagc 355620 agttgctgaa ctgagaaaag acagaggtga ctggagggtg ggggtggcgt gcaacactag 355680 aaagaggcag gcctgcaagg gaaaattgcc agagtcccag caatgcttga caataagaga 355740 atcgtggcaa aaaggttagg cagaagcaat cactctctgg tcatattttg caggtagaat 355800 aagtaggatt tgttgacaat gtgaacagga gatatgagat aaaaaaagag agcaattacc 355860 aataacctcc cagaattttg ccttattacc tgtcaaagag aaaaatagat ttttcactag 355920 aaagcattta tttttaaaaa agaataagag aacacatttg aagtgttcgt aattaaatta 355980 attttagact ctaaaattgc actttctttt atgatatcgt aagacaaaat actttgaaat 356040 tttacaaaca tcttaaaaca cgggggcaga gactcacaga ttttataagc tggtgaagtt 356100 ttatgtttga attcctcatg tgcccaagtc acgtaaaaga ataatggagc tcatccatgt 356160 catctgtagt ttaaaaagtg accttaaatc tgttttaatt aattattttg ccaaagtttg 356220 gcaattttag agaaagttga agaatgattt ttacactaat agaagtcagc aaaaatcccc 356280 agtgacaagg aatccttgtg tgaatagaga atgctggtgt ttatactgac acattttcat 356340 gtccatgaga cagaaacctt gcaggacagt gggagagaat gtggggataa aaactaagca 356400 aagaaagcac attaacaatt ggtcctcatc ctaccaagtg ccagaagctc ctgcctgcac 356460 tgccaaatgg ctctagacaa cctctttgtg acgtcagggt gggggtactc cagccagacc 356520 tctctcaaat cttttctcaa gaatgaggtg gaagttaaac aaagacttcc caaccctaac 356580 ctccttcctc tcacataccc ttacctgatt cctgcatgga gaggaggatg gtatgtgatc 356640 catcagccac acagtgggaa agtaatattt caacatccat gtaatgaaaa tatactgtgt 356700 gaacctacat agtaagtaaa agaaattaaa atgtctagaa tccaattata gattccattt 356760 ttttaaaaaa atactgtatt tattgtgtat aacactgtcc ttagcaaatc acatagacct 356820 actgatatgg tttggttctg tccccaccca aatctcattt tgcattttat ctcccataat 356880 tcccacgtgt catgggaggg gcccggcagg aggtaattga atcatggggg tgggtctttc 356940 ctgggctgtt ctcatgataa tgaataagtc tcaggaaatc tgatggtttt ataaagggga 357000 gttcccctgc acacgcactc tcttgcctgc tgccatgtag gacatgattc tgcttctcat 357060 ccaccttctg ccatgattgt gtggcctccc tagccatgtg gaacagtgag tcagttaaac 357120 ctcttgcctt tataaattac ccagtctctg atatgtcttt attagcagca taagagcaga 357180 ctaacacacc tacaaaatct tacgttgtat cctaactgaa taatatatct ttgattttta 357240 tttccatttc caaaatttag gggatggaag atgtcttagg gttctctgga gaaacagaac 357300 caatggtact tatttttttt tttttttttt tttttttttg agacggagtc tcgccctgtc 357360 gcccaggctg gagtgcagtg gcgggatctc ggctcactgc aagctccgcc tcccgggttc 357420 acgccattct cctgcctcag cctcccgagt agctgggact acaggcgcct gccactacgc 357480 ccggctaatt tttttgtatt tttagtagag acggggtttc accgttttag ccgggatggt 357540 ctcgatctcc tgacctcgtg atccgcccgc ctcggcctcc caaagtgctg ggattacagg 357600 cgtgagccac cgcgcccggc ccttatttat atatagaaga tatttatttt aaggaattgg 357660 ccaacgtgat tacggaggct gataaatcca gaatctgcag ggtgggccaa gaggttggag 357720 accttgagaa gagcaaatgt tgcagtttaa gttcaaagtc agcaggggac ccaggaagga 357780 actgatgttc cagtttgaag gccatcagca gaagaattat tttgcttgag ggagctcagt 357840 ttcctgttcc atttaggcct ttaactgatt ggatgaggtc acccgcatta gggagggcag 357900 tctgctttgc tcagagtcca ctgactaaaa tatcaatctc atccaaacac accctcacag 357960 aaacacccag aataatgctt gactaaatgc ctgggccccc tgtggcctag ctgatttgac 358020 atcaaattaa ccatcacaaa attttctttt ctttatgcaa attttatagc attacttttg 358080 tgttgtggtt ttttagaagc atagacctag agaatagtgc ccatgacctc tgactatcct 358140 attatacatg aggattgcat agtatggtag aatctcctat aatattcttt ccacgtggct 358200 gcagaatctc tgtgaattct ctttgaaatc gctgtgaact ctcttgaact catttttgtt 358260 ggcttttggt ggggaaataa ctagaattta aattgtgtcc agtaaaggtg attctggaaa 358320 tgaagccaag gaaaaataaa ccatttgctt aatctttcaa ggggcacaat aattggaaaa 358380 gacaatagtg aaataaagct ttttcttttc actgttcgag ctataatatc cctcccaggt 358440 gagaggtatt ctggctgtaa ttcccaaggg aacccttgtc acagtggcgt ctttagtgag 358500 atgatttgat ttttaccttt tttcctttgg gtggatgcct ttctcctctt cttgactgtg 358560 catgtgtcac tctgtgccca cggagacaga aaagaataaa aagcttacct ctccccctga 358620 aatgcagcag agtcaaactt cagagttcag cagtttctca ttgaaactat caggcaatct 358680 gatgcagaaa gacaacctca gacatgactg agccttcaaa tagaagtttc cagagaccaa 358740 acgtctcttt tcctggatcc ccgatatgga gagaagccgt gatctccaca gagacttcca 358800 agctctctgg catcacttta gcagagcagc ccttgctgcg gaagcagaaa ctcagagagg 358860 aagggctttg ctgctggggc tcaacaaagg tgtccgtctc cagccagcca ctgttccagg 358920 tgcggagtac agagagggcg acacactcat agagttggta agttcattga gaatgggtgc 358980 ataacaggaa aagttttgat taatgtggag ccttaattca aaatgtggtc cctgaccagc 359040 aagatgagca tcaactgtta gaaagacaga aacatcaacc cctctctgga tctcctgaac 359100 cagtgcctgt gttttcataa gataccccag ggatttgaat gtgccttagt ttgcgaagtg 359160 ccatctagag tgtacaagaa ccagaatgta cataaatttg actctaatca actggcaatg 359220 gcctcttcac tatgctggct acaactctct tctctctcct gtgctcctta tctcagtgaa 359280 tagcagaacc atctatgaaa actcatgcca aaaacctgga tgtctccctg gaaacagccc 359340 tcaccctcaa gcagcttcat aggttctctc tagaatgttt ctagaagctg cccatcttca 359400 ctgcctctcc cctggttccg tctctaagat tattaacttt ctcacgggct tccttgcctt 359460 caccctcagc ccttccaatg gattccccac cctgcagtta tgctgatttt gctaaaattc 359520 aaatcttctc atgtatccct ctgctggaaa tggttgagta gctctgatta ctctcagcat 359580 gaacccacat gacttggtgt gacttctacc tctctaagga tgtggctcca gcagccccct 359640 ccagcctcac ctcatgcaac acccaagcct gcctgagaga caatagcagt atgcttcact 359700 ggtgaaatgt tttatagcta cctggagtgc ttaccctcta cgtgtgagca ggcagtctct 359760 ctctctctct ctctctctct ctctctcaca cacacacaca cacacacacg cacgcacaca 359820 cgcacacatg cacacacaca gagagagaga gagagaggga gagaaagaga gagagagaga 359880 gttacaggtt atagagagag ggagaaagtg ctttctcacc ctgagattat tccatgaacc 359940 catagataag tcagaaccag gaattacata aaaggcccat gaaaggttaa atttaaagga 360000 tcaaaccttt gtgctaaaga ccctgcttca aacatgtgga gttcctcatg gtcttattct 360060 ctgagtctgc atgttgttgt taccacctgc ttacctggtg ctcccagact gttagaagca 360120 gaaagtgaga ccaagcagag ttgctaaagg caggcactga tgaccccatg ccagcaggac 360180 tggcacccag gaaggagcag aagtactcta gggagccaag caggagctca gcggaggcca 360240 gggtgagggc aggtgtccta caaatgtcaa ctccgatggt agctgatttc aagctctgtt 360300 tgatgacaga tgttgatccc agtggtttca agcttgagcc attcaaggaa cattagaaac 360360 tagaaaggaa atattgcata ggttcttcaa atatcagttt accccgtgaa aattcaagct 360420 ttagtcctaa tgcttaaaca gtgctgtatt aaggtctgtg tgcacttcaa ggttaaaacc 360480 tgaactgtaa aatatcattt tttacagtta tgggcccttt tatgctacaa ccccagaccc 360540 cctgagggcc ttctcattcc ttccttctcc ttccccctcc ctcccctgcc atcccctcct 360600 ctcctctcct ctctccttcc ctttcctctt ttctttctct ttttcttctt tccttccttc 360660 ctgcctgcct gcctgcctct tttacttgac atttattggt gagtaaatac tccatgccag 360720 gatctgagtt tacaatggtt ggtggctagg atggacagtc tggagtcatc tgaaaaagga 360780 cagtcaagag gggaaggacc agccagtata aaggctgtga gttgaaagtc atagagagag 360840 tagtggaaag aaaggcccag gataaaccat gccgggtgat tatcccaagt cctggtgaat 360900 gcatttcatg tgctttgttg actgtgttac tgtatattca ctagcaactg agtggatagg 360960 ggtctctcct tatagttggg tgatctgtta gccatctatg gctgacctct aggaatcagg 361020 gagggtcttt tgatgtgtaa tttgaatatt agctatatct caggctttat ttttgctgcc 361080 ctcagtttat agtacgtagt tttgtaagct gccttaaaaa cttttagaca caagcaagtt 361140 aaaagaatat gcagtagatt taaatgaggc tcctatttaa aaacatttaa taaaagtaat 361200 ggtgtaataa ttgtgttggt agtcaaaagg taaatttcag actgtgtgta tatgtgtgaa 361260 aagtcagtgt gtatgtatgt gtatgtatat atgtgtgtat ataaatatat aataacatac 361320 aatataaaat atacatttga cacacaattt aagtatacag gtttaagata ttttaaagtt 361380 aaataacaaa tagaaataac atatgcatgt aagtaacatc taaattgttc tatttaagta 361440 tgtaatttat aaaataaaat tatttaaact taaatacatt ttatttattt atttgttatt 361500 ggtggattca aaaactactg atgattagcc ttctgtatta gttccttctg tgtctggtag 361560 aaagtcagtg tgggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggcc 361620 gaggcgggcg gatcacgagg tcaggagatg gagaccatcc tggctaacac ggtgaaaccc 361680 cgtctctact aaaaatacaa aaaattagcc gggcgcggtg gcgggcgcct gtagtcccag 361740 ctactcggga ggctgaggca ggagaatggc gtgaacctgg gaggcggagc ttgcagtgag 361800 ccgagatcgc gccactgcac tcactccagc ctgggcgaca gcgaggctcc gtctcaaaaa 361860 aaaaaaaaaa aaaaaagaaa gaaagtcagt gtgatattga aatatgtaga gtggctgact 361920 gtgttttatt tttggagggt ggatgcaaag ggggtagcag ggagcttagt agcaagggac 361980 ctcagtgagt cttgtgttgt cagtgaggcc agaaattgat gtaggcggag gaactaaaac 362040 ctagttcttc aattcctctg tataataaca taatgagact ctggaagcgt ctctaaaagc 362100 tgctggagga agcttcaagg acatgcagat gagtggaaat gaaggagcag gagcaaagaa 362160 aggtgacctc catgacagag caggaagcta caggctggga ctgttggcgt caccaaaaca 362220 ttctctgcag gagggataga caagaactta tagatgacag catctaccat ttgattttag 362280 gattttttca gtctttgcgc tgtgtggcaa ttgtcctcat cctacatctc cctgtataaa 362340 acaggtaacc acagcagact tatgtcagca gcactttggg gaatgaggga gagagagttg 362400 cattttatgc ttggcctcat gcaagctgga gaaagaacag cagcttcagg agatgacgca 362460 gtggcaggaa ccagaggaaa aaaaaccacc catgaacatt atccaagagt ttctttttta 362520 ggtgataaaa tcatgagttt catacaaata gcagatgaac attgagtcaa atattttatt 362580 taactcattc atgaatgagg gaattgctaa gatgttgcaa ctggttccat tgaagattct 362640 atccacagag atttgttttc tatggggcaa aatgtatttg cagcactgag aacaggagtc 362700 ctttgccttg ctatggacag gaagtgtttt cattgcttta tgttttctat cagttaacct 362760 ctatctctgc agagttgtaa acagtcaagt caaagacaag ctaaggtata gataggatgg 362820 atggatgaac tggatagggc atttaatgcc cacttactca atttctgccc acttccacct 362880 ttcacaattc tgccggacaa tatatttgag acggtgaaat attcgggaag cctctggaca 362940 gacccataaa tcgtagtctt tggatgtgga ctttgtttat aggtggggaa cctgctgaag 363000 attagatgag tttgggtggg ttgagacatt ctcgaaagca agaaccttgt ctaacatctt 363060 ttgttgccga ggacctacat cctgccccgt agaattaaca gttcgtaatt attggccaat 363120 agccaaaatg tcaggattaa aattgcttac ctctcagaaa aattaaaaat acttcctcag 363180 ccttggtaag gaaagaagtg attaaacatc tagagtttta actttctatt aaaattttaa 363240 attggaaaga accatagtca tagaaagcat tcacagcaaa ctttaggaac acacaaaaga 363300 cacgtgtgta ccagggagcc cacgcacgtc tgggtactat tgttaaaatg agaagaacta 363360 ggcacactaa tctattccag ggataggatg cttgaaatgg acaaatagta atctaggttt 363420 attaatgggt attcatagtt gttaaaggaa ttatatataa ataatttcca acaaacagct 363480 taagaaattt taacttatgt ttaattataa catgcctccg ttatacagga aaataaaaag 363540 aaaaaaatta tcattgtgta atcaggcaaa aacatcatgg cttgttgatc ctcacaataa 363600 tattgttagg agaaatagct attaaagata taattcccat ggtaatttcc tgttgaaatg 363660 tttggccagt gacactaaaa ccaagccaac ttaaataaat atattgcccg tttaagttga 363720 tttcacttaa aaataaccca cagtaatatc ataaatgcct aaaaccatac ttatccataa 363780 taggtagctg ttttttcctc cttactattc aaatagattc gacatgaaat gaaagtaaaa 363840 tctcacaatg gtgaaagact tctggaaatt ttaaaataga tatttgctaa tttgtaagtc 363900 ctgcaagatc atgaggagtt tgtgcttttc tgcagatgca cctgcatgtt tacttttccc 363960 attaaatgac atttcttctg tttctaatct tctagagatg cagaagaatt gcgtgggaca 364020 ttttaaaata ttagtcacaa ctaatttgtc atcaaatttt gtgagatctt tcactgacac 364080 agatgatcag tatataaaaa gcaagtcaaa tatactttaa aaaataatta catccacagc 364140 accacaactc taccttaata aaaatttcac aattaggcgg gctgtgtgtc attagcctcc 364200 ctgatagcat tcagtgtatt gtcacctcat gttcaagcac acatctgata gaagcaagac 364260 attctgccac ctcattccac cttctctatt ttacaccttt aaaagtgtgg aggtagtgtg 364320 ctaagagtta taaattgtct tgctgaaatt ctttgggaga aaacataggg ggcttccata 364380 taaaataaac agtgagactc aaaaattcta gaatcaaaca tttattgccc tctgctgtca 364440 gggtccacct cctgggaatg tgtgttacct tttgctctaa ttctttttga aatgtctcca 364500 gagagtatga aaatgtagtg atttctctgg ttttgatttt caaaaccaat aaagtttttc 364560 ctttagtcca atttttaaaa cacaaaatgt tttcaaagta tacccatgtt gtagtgagta 364620 aaaattctga aaaattctct atattaaaaa ataaaaataa aaaagttgag tctagaaggg 364680 gcagagagca aagaacagtg tgaaatatct acagatgaca aagacagtca ttagctttat 364740 tattttgggt gctaggcacg tgttttcaat gtagttatac tctcccacag ctataagggc 364800 ataaagctac atgttagaaa aagtgcttct gacactacat aagtgtacaa tagctacgtt 364860 tagaactgtt cagtgtggtc atattttaaa attatgaaat gtagggaaga aatgcaatta 364920 tgtgaataaa aagactggaa atggtcttca tttctatgca aggatggcca caaaaaaggt 364980 gacatggagc cattttcatg tacaaataaa tgagaaataa tctcacaagg aggtgagagg 365040 ctgcacttgc tcttcccccc ggagtggtgt tgccatggta attatagtga cttcagacac 365100 ttctgagatt tctggtttca cactcaactg ggaacggcga atcgcctcta tgggtgacag 365160 gatccacttt ggatcaataa gcagtgcacg tgtgttccgg gtctagctct gcctttcatt 365220 tgctgtagct tcataaattg ctctgtccct cactcaactg tgacacgggt cctgtctgcc 365280 actccgggtt gttatggatg gagagccaaa acgcagctgc tcaggaagta actaggcagt 365340 gcatgtgggt taggatggca agatttagtc tcatcatttg ttgtttccac agttgaatat 365400 agttctggct ttattatgaa ctttaaaaat cagaagaaga aaatcacact ttcgtagtgt 365460 tgttggatta tttttggtca tttccactca tactgaaaaa tgctgggtat ttgagtccat 365520 ttcattgttc ctgagcaagg ctttcctttg ctcttgtgag cttttttttt tttttttttt 365580 tttggagaca gagtcttgct ctgtctctgt tgcccaggct ggagtgcagt ggcatgatct 365640 tggctcactg caagctctgc cttctgggtt cacgccattc tctgcaagct ttgcctcccg 365700 ggttcatgcc attctcctcc ctcagcctcc cgagtagctg ggactacagg cacccgccac 365760 catgcctggc taattttttt gtattcttag tagagacggg gtttcaccat gttagccggg 365820 atggtctcga tctcctgacc ttgtgatctg tctgcttcgg cctcccaaag tgctgggatt 365880 acaggcgtga gctaccgcac ccggcctgtt cttgtggtct ttctacagga agtgactttt 365940 gctgcaggga gcttctgttg ggggaaaaat gaatttaata gttttgaaat agtgggtttt 366000 aaaaagtgta tgcccaagtt tatttgactt acagttttgg aggctgagaa gtccaaggtc 366060 aaagggccgc atctggtgcg ggccttctag ctgcagcatt tcagggtgta gggcatccta 366120 ggcccagagg gcaaaagcat ggcctaaaag agttgttttt ttcccagatg agaataaatt 366180 gttaattctt tcccaaatca gtaattttgg taggttgact aaaatgtttt ctgattgcat 366240 cagagaaaag atataaatat tgatatttag agtgcctttt gaccttgagc cagtatcatc 366300 tttaaggtcc agttatgtga aattcaaagt gtcagtgata atggccttcc taatgtacat 366360 tctttactgt cacttaaact ttctgcactc aaaaccatgt ggcacatcgc tgtttaatat 366420 gacagtccag cacgaggcct tacattcaca accttcagta gcaacagcgt caaatttcta 366480 tcatcaaaat tgtagcatgt aaatatgtca catgaagata ggtttcaata cagaatgtac 366540 gtgagagata agtaatgtct acaaacatta aaaattcctc ttgactatgt ttcaagtttc 366600 tagaaaatga agtatgatat ttgcaaaaat atagcttcaa tgtgttatgc atagaactta 366660 atgtgtgtga ggctatgaac aagactgtct cagtctctga cctgttattt gttcacactg 366720 agttcagatt tttaaaggga agaataccag gagggaaaga gcaatactct ctcttcccta 366780 aaaggctttg ggaaatgctt tatctcatgt gttagtgatt ctttaacttt tgtgtataca 366840 gccacatcta gaaagagact atttcctttt ctaacaggag cctatagatt tctaaaagga 366900 gcctaagtca gggcacaagg aactgcctct gggctgtgag gctggagcag cctttgaaca 366960 aggactccca gagaaatggc gtttgacctt cctctgcctc atttctggcg ttcttgtttc 367020 ttaatgttgg gtgcaggcag tttctgtcac agctgactga gtttgggggt aaaatattgt 367080 ggcacaatat ttagttttgt ttaattaaat aaatgacatg gtaaacaaat ctcatacatg 367140 ttgctatcat ttacctggca caaaagacca ttagctgtgt gtgtgagttt gtgtgtgcgt 367200 acatgcatac gcatgtacac acacatatgt ctgaaaataa gattcaaaat atttacaact 367260 tatttttctt cactgctagg atattcattt ttactgctga cagattttta aaaatcatgt 367320 cagtccatgt ggagaatccc atgtgatatg gtctggctgt gtccccaccc aaatctcatc 367380 ttgaattgag ctcccataat cccctcgtgt tgtgagaggg acccagtggg aggtaattga 367440 atcatggggg caggtttacc catgctgttc tcgtgatagt gaataagtgt aatgagatct 367500 gatagtttta taaagggaag ttcccctgca cactttctct tgcctgctgc catgtaagac 367560 atgcctttgc tcctcctttg ccttctgcca tgattgtgag gcctccccag ccatgtggaa 367620 ctgagtcaat taaaactctt tcctttataa attacccaat cttggatatt tcttcatagg 367680 agtatgaaaa tggactaata catatgtgag atgtttctaa ggggactaag gaattaagca 367740 tatcagaaaa catagatgag cagatgttac ccctgcaccg ttaatgatga tgatgattgt 367800 gtacttccct gagcagatgg aagcactggg ctttataggg tagtaagagc tgagtttcat 367860 gtccaatgga cctgagtggt gagtggcttt ttcatcttgg ttaaattact catggccatg 367920 tctctggctt catcacattt aattgaggac aataatagaa tttataggat tacttagacg 367980 ttgaaatgcc tcattgcaat gaagcactta gcacagcacc tggcacatag gtgggcttct 368040 gttcttacag cattcttccc ccttatctgc agctccactt tctgcagttt gagttttcct 368100 tgatcaacca tggtctgaaa atacatgagt gcagtacagt aagatgttta gagagagaga 368160 gaccaaattc acataactca gaatacagta tattgtttta attgttctat tttattatta 368220 tttattgttg ttaatatctt actatgtcta attttataaa ttaaactttg tcacaggtgt 368280 ggatgtatag aaaaaaacaa agcatataaa ggattcagta ctatccgaag tttcaggcat 368340 ccattggggg tcttggaagc tgtgtataag gcagggctac tgtatttgtt attttgttgc 368400 agtcattgta attagttgta gttgtggtag tagcagtaat aacagtagtg atcattgtta 368460 gatttatagt tctttgctca aaatctcagt tcaacacctg aaattaaaaa tcctccctat 368520 tggccaagaa ctgatttttt aggatgttcc atatattttg aagattatat gtaacaaaaa 368580 gtggctataa ttttagtaca atgtaacttt ttacaatttg ctattttatt tggtgcatag 368640 aaattaaggt catgcaatca ctttggaaaa tgaccaatct ttttaaaagc tggctctgtg 368700 cctaccctat ggcaaagcca ttccactccc agctatgtcc ccaaaagaaa aaaatattta 368760 cctatgtcca catgtactac aggttcccag gtacacacag gcatatacag tgttcttggc 368820 agcacttttc ataatagctc caatcaaaaa actatgcaaa ttcccccaaa cagctaaatg 368880 gagttatgtt cattcaatat aatacagcta agaaatgaga atgaacagcc aacaactaca 368940 cacaaccatg tggataaatc ttgaaaaggt aatgttgaag gaagagagac agacacaaga 369000 gaatatattc tgtgtggttc tatttacata aacttccaaa acaggcaaaa cgaacctatc 369060 ctattagaaa tcaagatact gggtggcttt gaaagaagag taatgactat aaagaagcat 369120 ggggggtggg gctcaggggt cctggtaatt ttttttctct acctaaatgt gggttgcatg 369180 ggtgggatca gttggtgatg attcagctgg gctattcagt taaatgtact cttctctagg 369240 tatattacac tttactgaca agttttttaa aaagacagaa aaaaatgtca gtggagaaaa 369300 tgttgttatt ttatctttta aaatactgaa taaaatgtta acaatttaaa tgaaaatgca 369360 tgattggatt ttagattaaa tatatcattt tgataatatt ctaaaataat tacaaatttg 369420 tgctcaaatg aaaagcagac ctctcagtgt taataaacac tgtgtgtaat tcagttcctc 369480 aagtagtatg ggttttatca ctttcttcca aaacataaaa aagtgaaact tactaagttt 369540 catatgctgt tttaatgggc aggttctctg gaaaggatgt aagtacatat ggtggaaata 369600 attatagatg actcacggcc atcagtggaa atttacacgt cctttggaac ttcaatactg 369660 agcatctgag aaattgcaaa tttctactat agaaaagacg atcagaaaaa ataccgtttt 369720 cttttttttg ccattatcat tttttaacta tctccttttt tgtgtgttaa gcatggtatc 369780 tcctttttcc tatttctttt ccttttcttc tggttcttat cttttgttag atcaatttct 369840 gattttctat ggcagataga gagctggttt tatttttcta gactattcag tgaaaaagaa 369900 ttcatattcc tctttatttg tgaatattgt atgaatgagg tttgaacagg tatattttga 369960 aaatttcttt ttaaattaaa acacatttta tacttttcca cattgagatc ctaaatgcct 370020 gtgggctgac tgcagtcttc cttaaatact atttaggaag ttatataact tttgttttct 370080 ttgagctctt cccaaatatt ccaaatttca tgcaataaaa tatacttatt tgtactttaa 370140 attttaaaat gaacattatt tttatcaggt cttggcttgc aaaattatgg tcacaggact 370200 aaggtgagaa agtaaacgtt tttcctactc tctctgaatt ttccctcaag ttttttttgg 370260 cagttcatgg ttaattggat tgttcacgta gagaactttc cactcattct tcttattgag 370320 gccttagcag ggaacactgt ataacatagc ctacaatgac tgatttttga gcccttccca 370380 tcaaagcttt ccctatgacc tgccctgccc accacctaac caatggttag tcagcaaaga 370440 ataaattctt tcccccaaaa ctccccagtt atagtcttct gaaattccta gagtcccttc 370500 tgtcctcacc ttaagcacat tcgaaagctc attgtttagt taagaccaca aacattttag 370560 ctgataaggt tgtgagcaaa ctctatttta aacatacctc ttattaaatg tttgtgattg 370620 tcactatcat catcaatatt attatgataa attgatcact atgtgccaga cacttacctg 370680 tgcattttgc atgcaatata tgcatattaa tgttatctaa aaattaaagc cttataacaa 370740 ctcaatgggt tatattagcc tctaaactga ggctcaggaa agttaagaaa tggtccaagt 370800 cgtatccatg atgaatggct gagctgtagc tcaaactcag agttgactgc cctttctcat 370860 gccatattat ctccctaaaa ttatcgatat accttcacta agggccttca aatggggacc 370920 ctcctataga aatacaagga cgtttctggc atagcccctt tctctatgag gtggttagta 370980 cagcatggga gtgaagcacc caaatgggga ccctcctata gaaatacaag gacatttctg 371040 gtatagtccc tttctctatg aggtggttag tacagcatgg gagtgaagca cccacccaaa 371100 gatgaaacac ttgtggagga aagaagccta ataggattgg ataacctgac agatagttcg 371160 aatgtcctac aaaatcaaaa atggaatgaa ataccaactt acacacaaaa gaaacttgaa 371220 actactcaaa tggaataggc tgatgtgttt ttttttaaat tttatttatt aatttattta 371280 tttaagacag agtcttactc tgttgcccag gctggagtgc gacggcacga tctaggctca 371340 ctgcaacctc cgcctcccag gttcaagcga ttctcctgcc tcagcctcct gagtagctgg 371400 gattacaggc gcatgccacc aagcccggct aatttttata tttttagtag agatggggtc 371460 tcaccatgtt ggtcaggctg gtcttgaact cctgaccttg tgatctgcct gcctcggcct 371520 cccaaagtgc agccactgcg cccggccagg ctgaccattt tgtatgggaa agtcagcact 371580 ttcgtgaatg aacacattga tcaagccact gaggaaaatg tgattcaaat cataaggagg 371640 ccaggacgaa ggtcacacaa agagcccctg actctaatct acaatcatga cgaagggggc 371700 cccagtccag ttctaggaga agcctccctg ccacatcctg tgacaagttt cacaccagca 371760 gggatcttgc tgagccagtt aggtgggctg agtccagccc tggaagatgg gccatcctcg 371820 tgtccttctg aagggcactg gcctgaatgc caagacctaa ataaaagcag attttgaagg 371880 tttaaacgtg gaataaaccc aagagtgacc cagaggagcc agctgaagtg ctaatgcacc 371940 ttcacaatca aagatatgaa agcttgtcat taattgcgca cgacagtctg aaggaggagg 372000 gtggagcatc ttgctggctg gagaaacttc tggaaacctt aagtgctctc caacttcagc 372060 atccagggta ggtgaggcaa cagcaagcct actgactgtt tggggtgatg ggcttttttt 372120 tttcctggag agatgccaat cttcagaagc cctgagagcc tgcagagctc catggaaggt 372180 ctctggccta ggtgcccagg tgtgggtctg cctgcactgg gtctctgaat gagcagggct 372240 ccctcgcagt tctcgtcgtg ggaaccctca gaggacacgg caagaacaac gttcccctca 372300 gtctctaatg gacacggact gcccttccca ggcagaacgc acgcactcgc ctgcagaaac 372360 cttgagttca ccattattta ttatgtctgg gggatgctgc catcccctgt gatgcccctg 372420 attaatgata atgtgcaaac ctgaggtaat tcgctgacat gttagatctt tgtgaggcac 372480 cagaatggaa gcggcatttt tcaaactctg ctctgcggga gccccagggg ctgttccagc 372540 tcagggggga aggggagggc ggcagctccc gcggctgctg ctccattttt agctatttta 372600 tgtgtttatt tgtttacaat gcttgttagg attctggatg gacaaagaaa agtattgcct 372660 acaataaaag aaagaaagaa aaaacaatta aatggaatat tatatgctgc aaaggaacat 372720 gccaaggggt gcttggacca ttttctggaa ttttccagta ctgaatatgc ctttgtattt 372780 ttggttgtgt ttttttttaa tatttattat atatattttt gaagacggag tctcactctg 372840 tcacccaggc tagagtgcag tggcgcaatc tctgctcact acaacctcca cctcctaggt 372900 tcaagtgatt ctcctgcctc agcctcccaa gtagctggga ttacaggcgc ctgccaccac 372960 acccagctaa ttgttgtatt tttagtagag aactggtttc accatgttgg ccaggctggt 373020 cttgaactcc tgacctcagg tgatccgccc gcctcagcct cccaaagtgc taggaataca 373080 ggcatgagcc actacacctg gcccttgcct ttgttttgat gatcgtctgc attcatctgc 373140 tagggctgcc acaaaaacat gccactgagc aggggtttga acagcagtca tttgttttct 373200 catagttttg gaggctctaa gtccaagacg aagctatcag cagggtggtt ccttccaaca 373260 ctgtagatgg cacctcctct ctgtgtccta acgtggttgt cctccgtgtg tgtctgtgtt 373320 ctcacttcca cctcttccaa tgacaccagt catactggat tagggctcat cttgatgacc 373380 tcactttacc ttaatcaccc ctttgtaggc cctatgtcca aataccttat cccgaggtac 373440 tgggggttgg gacttcaaca tgaattttgg agggacatca tgcagcccat aacaaaatct 373500 gacaatagtt gtatatgcac attctgtaac acatagaacc tgtatgatct acctgatagg 373560 tgaccgctgc ccaatttcag agccctcagt tttggtcata tttgcgctgg tgttaacacc 373620 aggctattat ctaaggggtc ggcatccgca gtctatcatg ttggaaagca tggcagccat 373680 taggttggcc gttattgtca gatggcttct cagccccctc ttgatttagt tactgcctat 373740 gtcactggtg gattcccaat aagctttgta attaattcca gtacttgcct ttgtctattc 373800 aaattgtaca tgcagtataa ccttaaccac ctctaggtcc aaaatgaatg tgccactctt 373860 ggtgccactc tttgtgcctg cagcacattc tgcttttcta attcattctg ctctccttta 373920 gtttttaaaa agttaagagc cgttacctag ccgtagctgg caattcttgc ttgcaggtaa 373980 actgagttgc catggctgct ttttaggaag gtctctgcct ggttggtgaa cagccccttt 374040 attcccccag aacaacatgg atacttctcc tcaaataaat ccgtgccccg tatggaccgt 374100 ccgctttgcc agggaaatgg gtttgtagcc cactgagagg gctgacccat atgaccttag 374160 caacaaaaat atgaagtgca cagctgtgtt tgcaccatca gcatggccaa acaccctttc 374220 tcttctcgtt tctctccaca cagtgatgtg cattaactgg cacctggttt ctgcatcaca 374280 catgcatatt gggagaattg ttattctaga aggggatgga atgtgacaca cctcagataa 374340 ttgctctgag aaatgagtat gaggtctttt taaaaaaact ttacatttaa acacacaaac 374400 catttaaaaa aaccactcct ccaaaacaga cacacaagtg aaacaaacca aatcgactgt 374460 ccatccattt aattttgaac tatctgcaat atcaccttaa agctctaagc tcctaatgat 374520 tttggtcatt acaaatccaa aataacatta tttcaaaatg aagttttact atgatttttc 374580 ccatttggga aacagtatat ccaatacaac aagatgcatg tgtacctcca ttaaaatttt 374640 aacaattagg aaaattagaa tttatatatg atagattaaa atatgattat ttcctaaaag 374700 ttttctttag ttttacgggt ttgcttctgg attgctttca atagttatta gtgaatttaa 374760 aatttgattc agtatgaagg taatgtacac ccatcttctt cagaacacgt attttaaaat 374820 gtgacatcat ctgttctgag tctaagcact gaagaatgaa gtgtccacat tcaccgtatt 374880 tatgcacaga cacattctca ttccattgac atttaagtga tgtaatgaac taaaactgcc 374940 acaaagagag gagggttggg aggctgagct ctggacagct ctgtcactgg gcaagtaaca 375000 tggtgtttag aaaatctctg ctcctttctg tgccattggt ctatatctct gttttggaca 375060 aaaaaccaaa caccgcatgt tctcactcat aggtgggaat tgaacaatga gaacacttgc 375120 acacaggaag gggaacatca cacaccgggg cctgttgtgg gatggggaga acggggagga 375180 atagcattag gagatatacc taatgtaaat gacgagttaa cgggtgcagc acaccaacat 375240 ggcacatgta tacatatgta acaaacctgc acattgtgca catgtaccct agaacttaaa 375300 gtataataaa ataaaaataa aaattaagta aagtaaaata aaatctctgc tcctgtttgc 375360 tgtccccact gataaaatgg tagagcagat cactcctaag tcagagcttg tgtaatagct 375420 gcgtaggagt gtgaaaccag gctacttggg agccagtgct ggctccagaa ctttccagct 375480 gcgtgtcctt gggcaggtgg tttacactct gttgcctcag tttctccagc aataaaataa 375540 gaaaaaaatc atagccagct gatcaggttg ttgtggagga ttacattatt aaatcttggc 375600 caagccctcg gagcagactg taaccctagt actgtctcat gcataatcag ttactgatgt 375660 tgttttaaaa gcactgggtt aaaattgctg cacctaagat ctagaacctg ccctaccact 375720 gcctagctgt ggtggctgga ggcatagagc cccatagttg tggaaggaag gagtggcccc 375780 aaaggcctct acctagtgaa gttcacttcc ccctgcttcc ttccctaatg tggtttctta 375840 gagttgacat aagcatattt ctctgacaca caaacagatg actttttctg caggattggt 375900 cagaacttta gaagtaaagt gctcgagttg atgagataat ttgcagctaa ctgcttgaag 375960 ttcatgttgg ttatgctaaa ccttagagaa agaaagctac cgtttctgaa tctttaccac 376020 ttatgttttt atccgctctg acacattaaa gggagaaaaa taccagtaaa gaaatggcta 376080 gagaaaatgg aatatgacag ctagggtcta gggaggaaaa ccgtgaaaat gtctgtaatg 376140 aaaagaaaat tgctagacaa aaataatttg taatttgtct tctacatgtg gcattctaag 376200 actactgaat caatattgca agttctttgt tagccataat aatagtaatt tttaataaat 376260 gcccaggtga ggtggctcac acttgtaatc ccatcacttt gggagatcca ggcaggagga 376320 tccctttagt ccaggagttc aagaccagcc taggcaccat ggggaaaccc tctctctaca 376380 aaaaatacaa agattagcca tacatggtgg tgcaaacctg tagttccagc ttcttgggag 376440 gccgaggtgg gaggatctct tgagctgggg aggtcaaggc tgcagtgagc caacaatcat 376500 gccactttgc acttcagcct gggtgacaga gaagactttg tctcaaaaac ctaataaaca 376560 aaacacttca ggtgcatgac taagagtaag cttcgtgttg ggctcaaaat gctgttcagt 376620 tgaaggcgct ggagaagaga gggcagaaag ctcttggact cttggacagc ctcgcagaag 376680 caaaccttgc tccaatgagg gaggcaccaa atggcacagg tggctttggc aggacgttat 376740 tgtaagcctg ccacgtttcc gtggcataca gtttaggatc caaggttctt taatattgtg 376800 tttccatagc tttttcctgc aaggcagaca cgtaacatta atgagctcac agcactcttg 376860 gttttagtcg tagttactga atcctcattg gctgaaaagc tttgtgtatt aagttacaca 376920 atttttttct tttgcatcca aacttgaaat aaaacatacc aatttgatta ttttatatta 376980 attataacat gacttacgtc attgtggttt attgaggtta aaaattgatg tgctatactc 377040 agaagacaga aatgattatt aagataaaag aggcccctgt aattctatgc cccagagatt 377100 aacattttaa acatgttgga atagatttct cctttcattt tgcagtgaaa atatatggga 377160 ttacattatt ctaaaaccgt tttttccact gaacctatta cagcactttt ccatggacta 377220 catatgcctc attgttaaat tttttagtca aacactacat gcaaataatt ttaatgtcat 377280 atggttataa agaaattata acaacaaaaa actgagaatg cattccccgt tttcctccca 377340 cgaagaaatc actctcatta ttttttaact aaatttctgg tatttaattt ttttcaatct 377400 tattcatgta tttattgact tcatattgtg atggttcaga aatttaggtc actttgccca 377460 tattcccatc ctcccagtat gtcttacatt ttagttaaat ctattataat catgtaaata 377520 ttaagtgtca agccaagttg tgtgctatga ttacattttt cctttttgct ttaaacatct 377580 aacatttcca cacttcaaag cacaaaatga ttttccacat gttcaacttt gtcagggaat 377640 ttattctatt ttgtttttcc agcagagaca gctccaggag cccctctacc agcctccaat 377700 ctgaaggggc tgccacctta agtattcttc tcatgtctcc cctatgctgg atttcctatt 377760 tcctaaatcc tgtgctttcc catgtctttt tttctccctc ctttcagcgg gacataccat 377820 ccatcatttc tgagaaagga tgcatgagaa gaacattttt aagaacttat gtttgcaaaa 377880 agaatataag tttggaagta atttttatct tagaaatttt aaaaattgca aagggaatga 377940 tttctccatt gtcttttagc tgccagggta ggggttgtta tagttctgat tgctgacctt 378000 cgggtgtaag ttcactttct tccttttggg tgggcagtgt tgaggccatt ctctttattc 378060 ctgaagtccc gtaactttat gaaggtgtgt gtggctgtag tgtgctgggc actgagtggc 378120 atcttggaat gcaaacactc ctgcccctca atgtagggtg atttccctgt atttctttat 378180 ggatgatacc attcctactc tttccacctt tctctcccgc tggaatttct actgttcaaa 378240 cagacctcct ggatggaggt aatttttttt taaatcttta ttattttgtt gtacaaatct 378300 cctccttttt gacagttcag aaattttcga cttttggttc ttttctttat actaactttc 378360 agaaaatatc tacacttcca tcttaaatac ccaataatct gtttcagttt agccagagaa 378420 taaacccctt aggctatcga gatgcttctg gaagcagcat aatgtgcagc tgaatgtgca 378480 ggcggggcac gaggacgcag aatttcagga aacccctcct tgttcagccc ttgccccact 378540 ccaaacccca aaacctttga ggcctccccc tccccaatcc tgtgtgcaat atttgctgtt 378600 tttccattta ctccctgact tcagattgtt gagcttgagt tcatggacat ttcatagtaa 378660 ccctgaaata ttataagtct ctgaaatagt gtatttctct tcctttctct tctcgctcct 378720 tctcttcctc ctctctctgt ctctgctatg aaattaacta gtttcttatt acaaaccaaa 378780 aagtatctca gacaggtctc aatcgattga ggaggtgcac ccaggacaca ggtctgtgcc 378840 ttcctccaaa gatgattttg agggtttggg gatttaaagg agaaagggca gatattgggg 378900 aaagagaaag agaattttaa atttcagtga atctttattt ttacataaga taaaataaac 378960 atagggcaga ggaagcaaat cagatgtgca tttgtctcag atgggcagag gaatgactga 379020 gttctgtcct tcgtcccgca cctgtgaaga taagctatca atttatctcg tcagggtgaa 379080 atgcaacaga actattttag ggtaaagatc ttggggcccg caaggaattt cctagtgggc 379140 aaattgtgag ggagctatgt agtttttttt tttttttttt tttggttaat ctttgtagct 379200 atcttatttt ggaataaaat gggaggcaag cttgcctgat atagttccca gcttgacttt 379260 tcccttgggc ttagtgattt tggggtccca cgatttattt tcccctcaca taattgatga 379320 cattttagtc cttattcctt tacttttact atttttaaaa ttgcttataa aatcccaata 379380 tttgtgtatt ttttaatcaa ttcttagata agttactgct tactataaat tcgtgtacat 379440 tttacaatat tccatatttt aacaaattac cctcaaagac atatcaaatt attaagtttc 379500 atttctggaa agtatgtata aaagtgttga ttcttctctt acacttcctg acattaagcg 379560 ttatttttta atcaatttta tatacaagtc aattttatgc catcattcat acttctaaat 379620 acgtactttt agaaagctac atattcctga aaacagaaca cttattcttt ccacacaaaa 379680 tagtcatttg aaaacttctg cagatataga caagtaagtc ataaaacatt taaatgtgtt 379740 tacagagatc aagactaatt attttgtaga ttaaatcttt gtgtgcgtgt gtgtgtttaa 379800 gaagattgtg gggattaaat cattgtgtat atgcacagtg tttaagaagt taatgtgctg 379860 gaattaagag gcaaaggcaa ataaaattgt ttctaaaaat ttgtgaccta tctttgtgtc 379920 agaaacagct tatatttaaa tttgttgttt ctataagtcc acttaattgt cttgattgtt 379980 taaatacagg tagagtaata atgatcaaaa tctgggagcc ctctggtggc caaaatatct 380040 ttagctacag acatacatct ttggcttatg ttctaggttc tcaagatcta gttattttaa 380100 acttcttgaa agtataggca tttaaaaata atcaacagat gaacaaagtg aaataaacaa 380160 gaaaaaaatg taattgcatt aggaaaacaa tgtaaatttg aaaagtgata gccaggttca 380220 actcagttct tgtaagtgtt tttggaaact ggcaaaaatc aaatgcatgt atttgtccgg 380280 gagaagccac agtatcattg gaaccttgtc cactctcagc aatgcaaaag ccctttgagg 380340 tggtcccata gaaatttata acatgttacc ctcaatgaag tgaaggcatt taaattggag 380400 gaaaaaagaa aagaggtgtg ttagctgtct tcagaggtca gaagggattc tttgtcatag 380460 gatcacattc cttacctgga cagtgcaggg agaaacggaa gctgaaaaaa caaaacaaaa 380520 caaacaaaca gtttcaagtc catttaagaa ataaattatt attaaaaact atttttaaaa 380580 atggactgcc ttgataagca gtgagttgcc catcactgtg agtactcaag cagggagatg 380640 gaaacacact tgttagaatt gccatggagg ggactcaggc tctcaagctt gggtctaaag 380700 tacatggtct cttccagtgc tgtaaccctg gggctacgtg gatcaacaat caaccatcag 380760 gtaggaactg ttgatggcct cagagcctgt ctctttaaat cagagtttca ggaatgaaaa 380820 gtgatattgg catgagaggt cttgggtcta gacaggagtg aatgtcattt gtctcaagtt 380880 ctaggagggg tagatgtatc cagctgcatg ccgccttact tctgaaggga taaaagcaga 380940 gatggcttct gatctccagc aactccttag ttgttcataa gcaatgaatt tagaatcaca 381000 gatgggacca cacatatgtc tgtgggatgc tggcgtttct ttctgaacaa cagttccatt 381060 tttattgcac tccttgtgac cacatctgca tgtttcacag tctttttgag atttttgcag 381120 gcatgattcc gtcacccaaa acagcaagga tatgctactc ttatttctat gccttcaaaa 381180 acaaacagat ctgcagattt gacaaccttg ctgaaaatat tttttttttt tttaccaaac 381240 gtgtttataa tcaaacaagt tgtcagaaca aggggtcatt gttgctttct caagtatttc 381300 aagagtaagc tgtaatggca tttggagaga gaatataatt ttattctcta gaacaggggt 381360 gtccagtctt ttggcttccc tggggaacat tggaagaaga attgtcttgg gccactcata 381420 aaatacccta atgatagctg atgaactaaa ataaattgca aaaatgtctc atgttttaag 381480 aaagtttaca cattagtgtt gggccacatt caaagccgtc ctgggccgcg ggtggcctgc 381540 acgccacggg tgggacatgc gtgctctaaa ggaaatgaga tgaatggctc gtctcattat 381600 ttttaatgga acagagcttc tgtagttgat ctggatccat ttgaacaggt gatttaaccc 381660 acttgggtgc ctcagtttac tcatcattga aggtaccttt tcacatgcag ttctatatca 381720 aatgttcaaa cagagctttt gggagacgtt taagctcaga cctgaaagaa gagaaagagc 381780 cgctcatgat aactggaata acagcattgt ggggagagag aaaagcaggt gcaaaggagg 381840 ccaagaagca tttcatgtgt ttcgtgcagc aaaaggacaa cacatcccaa gccaagtagt 381900 agaaggatag attgatgaga aaggatgttg aagagacaca ctgatgccag atcttgcaag 381960 atcttatatg tacatgaagg gaattgggat cttattttag tgcaaagacg agccactttt 382020 aagcatttta aacagacgaa aacaatttta tttacatggt tcaaagatgg ttctgggcca 382080 gatgcggtgg ctcacacctg taatcccagc acttcgggag gccaaggcag gcggatcatg 382140 agataaagag atcgatacca tcctagccaa cgtggtgaaa cctcatctct actaaaaata 382200 caaaaattag ctgggcatgg tgatgtgtgc ctgtagtccc agctactcgg gaggctgagg 382260 acagagaatt gcatggatct gggaggcaga ggttgcagtg agctgagatt gcaccaccgt 382320 gctccagcct ggcaacagag cgagactctg cttcaaaaaa aaaaaaaaaa gatggttctg 382380 gggagaatga attagtgacg gaacaggaac agatgcagag aatccaggtg cacttgggac 382440 tgaacagggt ggctctttca aagatggagg aaagtgggta gaagtcggat atattttaaa 382500 agtgggctgg acaggagtac cctgatgttg caagtgagga aaactgaaga gtcgcaatga 382560 ctcctgtttt gtttttgctt ggacagtgct tgtagataga atgaaaagca atgcctttgt 382620 gtgtatgggg gttctaaagt gagggagtca tgaactgagg ctcagctttg ggaaccttac 382680 atttaagtga ctgtgaacag tttctacctt cctctgagcc tgttctctat ttttccccat 382740 tgtactcatc actttctaac atgctaccta gtttatttat cttgtttatt gtttcttgtc 382800 aatctccctg ctccacctgc tccctgctcc tgcattgaaa ggaaggtcca tgtgggcagc 382860 gatttactga tttactttta ttgatgttcc cagaacagtc ccggagcctc caaggcattc 382920 agagaacctc tgtagaggtg tgaaggaagc agtcaggctg cagagttcaa aagagagact 382980 tgggagatag aaatgtggga gaaattcata tgtggatggt aaaatcatga aaatggatat 383040 ggttacctca ggaaagagtg tgcagatggt tcaggaaaca gctggagaat ctctagttga 383100 tgtttggagg ggaaggatga gatggcaaag cagaaccagc agtgggcatt ttatcaggtg 383160 agaggttaga gggggattgt cctagaagcc aagaaaagag aggaatttca gaaaaggagg 383220 tgctcacctt cagaggtgct ttctagtgaa gtatgaggta aggccaacag ttgcgggatg 383280 ggtgtctagg gatgagaaga caaatgatgg agctcaggga acaagaagga tgccaaagag 383340 gctggaagca gatgttaatg atggtgcagc cttctggaac cagcctctaa ggagcagggg 383400 tctggacctg cacatggatg ggtggtgcca atctgtgatt tgaaagccag catggggacc 383460 aaggatggac cttctcttta tctggtcctg atgaaggtca ggaagagcag cagcctatgt 383520 tgcaaaggat ggggtgagat tgggtctaca gaggatgccc aagtttcagt taagacctgg 383580 ggaaagtggg gatgatcaga gcctatgctg ctgatattgg aggggaattt cagagaacac 383640 actggaagaa ctgatggaag aaggggtgat tggacaaatg agcagacatt cagtgcaata 383700 ccgggtggtc tcggtatgag cagtgaggct tgcatttctg atgctgattg agatggacag 383760 aagaatatca gggcactggg catagttgtt attggatgtt cagctatgtc cagctcacca 383820 catgtgattt aaactaggca tttggggttt atttttaaag tgcattttag aaattcccag 383880 ataactcctt gcttgcaagc cattatctag taggtgtgca ataataatga gcttctcaat 383940 gccatcattt tagtatccta aggaagtata ttacaatgct cgttattagg ctgaataata 384000 tgaaattgct gttttatatg tcaaatgtgg accaatcaag caatttcaga tggttcaacc 384060 tagcactcct tatagcagaa agtatgtcaa agaggaaata gtagcaacaa ttgcagtgat 384120 acaataaatc aactcttgaa aatactttga actatatgga ataaaaataa gattaacatt 384180 tctattttgc aaagttgaat atcagttgac ttttcagaaa tgactggggg ttgggaaatg 384240 actcttctcc tggcccccac atttaccatg tggcacctaa ctctgatcag gtgctacaag 384300 tgggaattct gctctagctt tcaccttagg gttgcattag aatcatctag ggattaagat 384360 tcctgacact caggctgtaa accaatcaat tagatcacct agggatggaa cccaggtatc 384420 tatacatttt aattggccct gagtggtttc aatgtatcaa gattgagaac tattgctcta 384480 aaccagtgct ttcaaactgt catgcatatg gttcacttgg ggatctttat tgccacctcc 384540 cctgcctaag cattctaatt ccatgggtct tgggtgcaac aaagatgtga aaatttttta 384600 aagatctcca cgtgattcca atgtgcagta acattttgga tgccttgctc agtctaaacc 384660 aagagctaca ttaagccagc ggttctcagg catgcatcac atcaggctta cttggaggac 384720 ttgtcaaacc agagtgttag ccatggctct aagattttta ttccagctgc cagaagatgg 384780 gtccaagaat ttgatttgct aacccattct caggtgacac ttctgctact ggtcttggtg 384840 ccacatcatg agagcctctg taccaggctc taatagaagt actcttgggt tcctgtttgt 384900 gggtggtatg gctgggatct cctatattcc ctgcatgaaa ttttcttatc tgaacttgca 384960 ggaaggagtt ccaagaggaa agacgtgggt taaaaatccc atctgctccc tactgcctcc 385020 ttatcttcct gtggtcattt ttctattctt ttctgccata ttcatttcct gctgctgctg 385080 ctttaacaaa ttagcacaca cctaagtggc ttaagacaaa gttattgtca tactattgtg 385140 gatgtcagaa gtccagagcg ttaaatgctc tcagtggtct aaaattaagg tgttggcaga 385200 gctaggtccc tttctggggg ctctagagca gttctgcttg agtttcccag ctttttgaga 385260 caacttgcag ctcttgactc acaatccatt agtcccttct ctctgcaaag ccagcaatgg 385320 ccattcaagt ctttttcaca ttgcatcgcc ggctctgatg cttgcttcca cttttaagaa 385380 ctcatgatta ccttggaccc acgtggataa tccaggctaa tctccctaca ttaaagtcag 385440 ctgaggagca accttaactc ccctttgcca tgaaacctta cacattcaca ggttctgcgg 385500 attgggatgc aaacgtattt gtggggggat tgggacatta ttctacctgt cacacctgcc 385560 tccccccaga ccccagagct ggaatgcttg agtgtgaaac cagctctgcc tcttagagct 385620 gggttacctg gagcaggtca tttaacttct ctaaactgct ggaacccagg gaaataaagt 385680 atctacctca cagtatttgt ggcagggcta cctactgtgg gtaatgaatc atatgtatgt 385740 gtgccaggtc ctggaaaagg gattttagaa aatgttatta ttattgttat aatgttcatc 385800 ttttgcaatt gtattaagag tttctgccta tagtcacaca gttcctcatt tcataggcaa 385860 acaccagttt ctcgggtatc ctttcagagc tactctatgc atgtataagc atatgcaaat 385920 atataattta tttgcagaag tggtaaagta ttatgcctat gtgaataata cttcattcat 385980 gttttttctt tcttttaaac agctgcattg ttcctatttt atgaatatac ttcatttact 386040 tagctagcct ttattgatga atattttgtg ttcaattctt ttgcaactat gaacagggct 386100 gtaactgata gtcgtataaa tcaataagct tgcatatgca ccgtatatct gttgtataaa 386160 ttcctagaag tgagtcttct gaatcaaagg ttatatacac tttaaacgtg tgatagatgt 386220 tgccaaattt gtctctgtat atattttatc cattttcatt tccatcagta ctatgagaat 386280 gtgtatttcc atatctcttt ggctgattca tgtcacccag cattattatt tctgccgttc 386340 tgacagttga gaataacatt tcatgttttt tatttgcatc tctcttttga agaaaaccag 386400 catcttttca cacatttctt agcaatcata tttccttttc aattaactac ccatttatgt 386460 ccctcatcca tcatgttttt gggtggttga tttttttctt taatggataa ttaataggat 386520 ttactcacag tttaaggaaa gatctatttt ctgtggtcta aattacaaaa cattttccta 386580 ctttgtttac tttttgcttt tgctgtaaat aattattttt tatgtggtta agtttctaag 386640 ttgtttatgg aatcataatt ttgtatcata ctcagatctt tgctatctta ggctacagaa 386700 aacaaaattt cccatatttt tgtctaataa taacattatt ttatgtttgt catttgtatc 386760 tctggaactt gtttttattt tttattttta tttttttctt ccaacttttt aaaacattta 386820 atgatattct attttaagtt ctggggtacc tgtgcaggat gtgcaggttt gttacatagg 386880 taaatatgtg ccatggtggt ttgctgcacc tatcaaccca ttacctaggt attaagccca 386940 gcatgcatta gctatttatc ctgatgctct cctttcccca atgccaccaa cagtccccag 387000 tgtgtgttgt tcccctcctt gtgtccatgt gttctcattg ttcagctccc acttataagt 387060 gagaaaatgc ggtgtttggt tttctgctcc tgtgttagtt tgctgaggat aatggcttcc 387120 agttccatct gtgtcccagc aaaggacatg atctcgtgga acttgttttt atttgatgaa 387180 ttcgatagga atgcaatttt agttttttcc acaagttcca gttgcctcaa caccatttat 387240 ccatacttga ttctgttttt cctaccgatt gctaccttat ttattctttt tttttgggtg 387300 gggggcaggt tttctttaaa atctggttgt ttttgcatgt ttactttaaa actggattac 387360 tttgctggag aaaaaaatat ctttcatatt ttgctagagt tgtttgaaat atatagatta 387420 attcatgcat tgctttcttt aggatattgt gttcccatct taagtagagt ctgcattccg 387480 cttactcaat ggtcattttg tgtagtaaag aagcatttca acgtgctgtt catatggttt 387540 gtacacattt tttatactta tgctttttgt ttctattgtg catggatctt ggatctgaaa 387600 gcatgcttct ttgtacatac ttaggcaacc tatttacttt ttacttttta ctcagtcact 387660 tcactgaatt atctttacca tgtctaagag tttttccatt ggttctcatg aactttttat 387720 ttatacagtt atattttgtg caaacaatgg taatttcctt tcttttttaa tatgcacagt 387780 tttaatttcc ttctcttatc gaatggtatg ttctagcatt taatttcatc actatctgat 387840 tcattccctg ttctcatttc taattttgtt ttgttcttct tttcttgctt agtttaatca 387900 acaatctaat ttttatttca aaacttttga tttatttaat agctctaaca tcattctgtt 387960 ttcgaatgca ttgattcttg tgtttatgat tttattaact tgttcctttt gcttttttgt 388020 tcgtatttta ttgatttttt ttctagttct tttagttgga tgcttatgtc atttattttc 388080 atcctttctt gttatttata tacgtatgtg tacaagactt aaaatgtctc ctgagcattg 388140 cttttaacat tttacctagg ttctactctc atatataact tttgtatatg ttctccagtc 388200 accgttttgg tttcctttgt gattcaagag tgaattcttg gtcataaatc ctgataagtt 388260 ctaactttgt ggggaaatat ttaatgaact tctctttgtg acctaacatg tcttcaagat 388320 tggcaatttt ttccttgatt gccgggaagg aatatgaatt atctgtcctt aggttacaga 388380 attaggtaaa gtacaaatag atctaactat gttgtttaaa tcttcattat ttttgctttt 388440 gatgtttaat caacaatcta attttttatc ttaaaacttt acatttactt aataggtcta 388500 acatgattct gttttcaaat gcattcattc ttgtatttac gtttttatta acttgttcct 388560 tttgctttcc tcatgcatat tttattggct tttttctagt tctttcagtt ggatgcttat 388620 gtcatttatt ttcatccttt cttattattt acatatgtat gtgtacgaga cttaaaatgt 388680 ctcctgagca ttgcttttaa catattacct aggttctact tcatatacaa cttttgtaaa 388740 tgttcttcga tctctggttt tgtttccttt gtaattcaag agtgaattct tggtcataaa 388800 tcctgataag ttataacttt gtggggaaat atttaatgaa cttctctttg tgacctagca 388860 tgtcttcaag attggcattt ttttcctcag ttgctgggaa ggaaggtcaa ttatctgtcc 388920 ttaggttata gaattaggta aagtacaaat agatataact atgttgttta aatcttcatt 388980 atttttcttt cgttgtatac tgggtcagtc atggactgag agatgtgaat tgaagtccct 389040 cactattgac atacttctgc ctatttaaaa aattcttgta ggtttcactt tattaaattt 389100 gatgtaatat tttcatcgtg tgcacatatt catacctctt acatgtttat tgctgagtat 389160 atgcttactc atcataaagg gccatgcttt gtcacaggaa tgctttctac cctgttttaa 389220 ctgtgtctgc tactcagaac atggccatgg ctttcctttc caatttgcct gatttgcctt 389280 tccacattat taatatttga tatttgtaaa tactttaaaa cttaccacaa caatgtatag 389340 ttaagtttgt ggtccaaagg gaggcatatg tagcacattc acattgtaaa tatcatattt 389400 tacgttattc tttctcttta tatctttatt ttgcattttc ccctcttttt ctgtgtaagt 389460 gtgtgcaata tttcttttca taatatgaaa atgtgggatg tttttagttt ttataatggc 389520 taactctgta attacaaatt gatataatac aggttttttt gtttgtttgt ttgtttgttt 389580 gttttatttt attatttttt ttgagacagg gtctttctct gtcccccagg ctggggtgcc 389640 gtggtgcaac tgtggctcac tacagcctca aactcccggg ctcaagcaat cctcccgctt 389700 cagcctcctg agtagctggg accacaggca tgtgccacca cacctgacta actttgtata 389760 ttttggtaga gatggagttt caccatactg cccaggctgg tctcgaactc ctaggctcaa 389820 gcaatcctcc cgccttggct ttccgaagtg ctgaggttac aggtgtgagc taccatgcgc 389880 agccagcctt cttctttttc caaatacagt gtcaacttcc cactatggcc agagatgaaa 389940 ttataaagta ttctaagtat gccactcccc aaattaactt ggttatattt ttattggttt 390000 ttccagtatt tatatcttga ttaattgatt tatcaccatt aaagaatcta tttgattcct 390060 gtataggcat ccctctatcc cttatctctc atcttctttg tcctatggac ttttgttaca 390120 gtaattctaa attgccatga tttacaattg atttctgtac agtaatttcc acagatattt 390180 tactcctaat actatagtta aatagaataa atgtggagag acaatacttt gctatggttt 390240 tgtgattttt catcatttta ttatgaaaag tcataaatat atagaaatat gaaaataatt 390300 gtattgtgag cacccattaa ccattacctg gattgtacaa tcaatatatg caatatttgc 390360 tttacctatt agctatccat ttagtgacac tcatcattcc attgtattca caataatttt 390420 tgtattgtgt attcacaata atttttgtat tattgtgaag tgtattgcac ttcacaataa 390480 ttttcagata gcaatcgact ttacctttga acacgttagc atacatatcg ttagctagag 390540 ttcaatatta gtggtctttc ctcattttct cattagctaa ttttttttct gattgtcagg 390600 aagattttac agcccctgca attcctgcct attttcccat ttgaaaatgt gacctgtaat 390660 catataatta aatgttattc tgcctgggta taacattttg ttttcttgag aatttcatag 390720 atgttatccc aatagtttca taagtagact gttactgtga gaaaatctga gattggtgta 390780 attttaattt actttttttt aagtgaactc taaaaaattt tttttctaat tataatttat 390840 ctacaaaagt ccaattaatg aaatactaat ttagatacag ttcttgctaa atttttaata 390900 tcaactattc ttagggcatt gtgatcattt tcatctgcat attcaagcct tcttgcaatg 390960 atacttctct attatttaaa aaaattatat ttaatacttt tttctttttc ttttctttta 391020 ttattattat actttaagtt ttagggtaca tgtgcacaat gtgcaggttt gttacatatg 391080 tatacatgtg ccatgttggt gtgctgcacc cattaactcg tcatttagca ttaggtatat 391140 taatactttt tagctcattt atgtgctgct cttccccgag cacaccagtt atgcagattt 391200 tgaatctcct tgtcttcttc cctgtctctc tcccttgaat attttttcct atctatctat 391260 ttatcatcta tctatcatct atcaatccat caatctattt atctatcatc catgtcgttt 391320 ttttgttttg ttttgtttgt tttttgagag agagcctcac tttgttgccc aagctggaat 391380 gcagtggggt gatttcagct cactgcaacc tccacctcct ggattcaacc gatactcctg 391440 cctcagcctc cccagtagct gggatcacag gtgcatgcca ccatgcccag ctaatgtttg 391500 tatatttaca gtagagacgg ggtttcgcta tgttggccag gctggtcttg aactcctgac 391560 ctcaagtgat tcaccagcct catcctccca aagtgctggg attacaggtg tgagccaccg 391620 tgcctggctt ggtttatgtt tctaatgcaa ttcttcctct tctggacagt gtctagtttc 391680 tttgggttga ttacaatatg gcaatcagtt tttttatttt ttaattccct ttttttcttt 391740 caagtattct gatagcttat attccatctt tctctcgtct gaacttcatc ttttacctct 391800 gctctgagct atttgattgc ttcattcagt tcttttcatt catgaccata catttcgttc 391860 aaatgattcg tcggctcaat aactactttt tctggtggag cattatgttc cacttgtttt 391920 tccagtgctt ctctgaacct ggtcttacat tacattgata tcaatcccat gctgggagct 391980 tcttgatcta tgtctcgctt tttggtggaa gtcttcctag atcaggtact tgcaaaaggt 392040 ttatttggag cggggaaagc ataactagat tagtaggagt catcccccat ttacagggaa 392100 gtaccttctg atatcaggtt acatttctgt gtgagttgtt ccacttcact tctctccagc 392160 ctaccaaggt cagcaggttg tgcgcagttt gtgattctga ggacctctgc ctcacccatt 392220 cttgtggacg tcgagataga atttatctgg ccctgcctct cctactattt tatggtgcca 392280 cacactcgaa aggagaggta cccatcacca aagtcatcac caaagtctgt gattaagcca 392340 ttggtagtgt ttcctctctg tatatttacc ctactttgag aagaatgctt ctgcctgaga 392400 tactgcagag accttcttgt ggcgacttct acattttcat ttgatttccc ttgatttggg 392460 aaggtgattt gcatgtacgg aaatcactta gtttttttca aagatgaatt gtataaactc 392520 tgcagctatt aaacacttcc ccgtgtgaac tctttgccca tccttcctct tcattctaga 392580 aggattcctt tctgttctat atagtgcctt tacattgtta tattgctttt tctgctttag 392640 tcatacattt tttaaagtgg gaaaattggg taattgaaaa ttgagtgttt cagagtggtc 392700 ttcacagaaa actttcacag atatggtttc atttcatcct tttgacaatc cttcaatttg 392760 ggcattgtaa tcttcatttc acagaagaac aaaagaaact cagagcacat gttatggcta 392820 aagccacata cgaacacgtg actaggctga gtttctgaca ccttcattgt ttcattatac 392880 tgcctttcat aactgggaat gaaacctgaa cagtcccctg aacatggtga gagtttagac 392940 atttgatata gattagaaaa aagagaaaat tgccctgatt catcatgagc agactttgcc 393000 atggtgacag actgtctaat tggcttatat atatctttct gtttcagtcc gtaagtttgc 393060 tcattaggat gtgtttttct ttatcctacc taggcaggta tttggggtgt actcgtgaac 393120 cttgttccca tgttagggcc ctgttggaga gtagaatagt ttcatgtgcc aggcataggc 393180 ccagccaagg acatatcccc tgcttcgatg tacttacaca caatggatgc ctttgctgat 393240 tcaagggcca aggctcttac ttccttttag tcttgttagt gactaattag ttcatctcct 393300 gagcttttca gttagaatac ttttacagga gggcagggac tgtttgtact ttatataacc 393360 tcagtgcttc aagcatttca atataaatgt ttcttaattg aatattatct gttcttaaaa 393420 gaagagttgt agcactttga tgttctactt ttgtttatct cttgtcaaca gcagcaaata 393480 tttattggca ttagtactaa gcaatgctca gatggatggt ggaattgtca tcctaaggtg 393540 ttggatcagg acatgggcag tggtccccaa ggatagctgg aaaatcgttg agggtaattg 393600 aagctttctg ggatgttttg caaatgcaaa ggaaaacatg cattttgttg ttgcaggcgt 393660 tttgtgcatt gaggacataa agtcatttgc ctgtcatagt gcagaatctg tcaggattgc 393720 agctgtcagc ttgtcagtgt gacctttcct agtgtgacat accatggaat tttatgtcat 393780 gctaggacaa tatgacagga ctgtgcattg ctttttcagt agatctctcc atccttatct 393840 tctcaagaaa gaatacattc tgaaagagat aagggagtac gcttatcaca tattaatcct 393900 ataaagtcag aaagcagata aaaaggttat acattaagct tgattttatg cagtaattca 393960 cataagtgtg tgatattact tatgtgtgtt tgcatgtatg tgtagatata cacatatatc 394020 tcacacacac acacacacac acacacacac acacacacac acacacacac acaaagtctt 394080 taaaattcag gaaccagaga ggcagccatg tttctgtcta gcagcaggca aagaaagact 394140 ggaaatatcc aaactcattt taaatgccat tctgaactta atatggaatt acctaattat 394200 gtctaattca acaactgaag cataaactac tgatttcagc ccaagccaga attttacaga 394260 tttccctatt ttcctgtata gaatataaca cttggcacaa atcctagatc acatcttctt 394320 tgcagctatt accaaggctc tatgagcctt ggtagagaat ggtttgcatc atgcactaaa 394380 aaaaaagcaa ctaaatccta acattttgag tttctttttt tctattggta gggaactctc 394440 acagacgttg atatcacata acctagtagc atcctgcttg ctagagcatg agtgctgtat 394500 tgtatgcttt atgaaataga atatagaagt ttgcttgata ctatttggca ggtaatatat 394560 tttatacttt gtataatgct aataagttat tagagtaact gttgaaacta aactttcaat 394620 tgaaaaatgt ttacgagcaa aacaagaatt gcatacgata tcactcttta acttcttaac 394680 ttcactaaat atcataaacc tctttatgtc ccgatgcaca cgtttcctga accagcttgt 394740 aaaaggtgta attgttcaga aatcagattt gaatactcag ttttttattt cacaagttag 394800 attgatgcat ttacagagta ttttccagga tacctccagg atacctgtgt gtgtgtgtgt 394860 gtgtgtgtgt gtgtgtaata tagtgtatac atagtatgta tatactatta tagatattat 394920 atagtgctct gtatctatat atagtacata tagtctgtgt atctatacag tgttctgtat 394980 ttttcattgg atgtattttt ctccacattt aatcatcttg attttgtgta taatgggtag 395040 gaaaaattat ttttgaaatt ctcctggttg aggggcctat cggtacttca tagtcccagg 395100 gaggtaatca attggaatct ttcagcagta gcgctgactg ttgagggacc cttctgtcat 395160 aaccagtatc cacagtgaac tgggaatacc tccttaaacc catttatgct ggaggttgca 395220 atttttttga atttttgcgt cagtgaaaaa tcagactttg atgatgacct tgagcagtag 395280 gatataaata actcccacat gtttagtgtt ccaataatgg aacacttggg tattgcattg 395340 atgttaataa tccaaatagt ttctggcgtg cacacatcct ccagccaccc tgaaattcga 395400 accctagtga tttgatttat ttgtacactt ctaggcagtc caccatgtgt tctggaaaca 395460 gttgcggcta aattactatc attgttgtgc tttggcacat ggatgtttga tgcaactgag 395520 aaagcaattt taatggaatt tattctgaca gctatatata cctggtgcag acttaatatg 395580 acatgatacg agccccacac acctaattgt gtaggattct tatgaataca tcacatggat 395640 acaaaaccaa gaaacactca attatctcat gtgtttgatg tggaaatttc tttactaccc 395700 caagtctgtt acctttcata accattaaag cagccccact aatcttttta taaagattta 395760 tgtttcattc aaaaagaagg gatgtctaag ccagtagaaa gtgccatggg gagctgggcc 395820 ataatagtaa gtgctctcct ttcattaaaa tacctcctgt tcttttttat aaatgctgga 395880 gactggcctt ctcttacatt gtggcccttt ggagtctgaa caacttaacc tcagccatca 395940 acaggcgatc caaattccag tggggcagag cctctggatg atggggctga atgcccagag 396000 atgacttgca aagcatctcg gaaatctttg gccttcctgc ccccaactcc actgacgtgc 396060 atgcttattt gtaggcctgc ccttgaagga caaggcatac agattttcat ccatcctgga 396120 atggtccagc caactggcca gaatgcccac caacagaaca tatcttgagc aggagggtag 396180 gtgacctgca gagattcaca cgtttataaa ataagattga aatcctaaga tgcaaaaaag 396240 aaacaaatag tactgttcaa tcgttactgg aaattttaca tatgcgttcc ttagtaagaa 396300 gcttcctata catttctttt cagagatata gtaatgtctg tcattaaaaa gcagcaacaa 396360 caacaaaact tacctttgat aaagtctcag tatattcaat aacaatcata tgtaacatag 396420 accctgtgag ccctgatggc ttagataaac ttcatgccta tgaaagataa aaatctcaaa 396480 catttgcaag caaattttat ttctgaatta aaacctatgt tgtaggctgt gaatatgggc 396540 aattcatcaa atgttctgaa gtcattgtcc atgaatccta aatcaagggc tttatccctg 396600 taaatatttt tttccaaggc catcaagctt gtgtttctgg gtaaataaca ttttttttca 396660 ttactgaaag caaagtgctg agtttcatgt agttgtgaat gaattaataa gattgtggcc 396720 agaatttgaa ggcaaacagt ggtacatcaa aaacatgtgg gatctatttt caagtgtcag 396780 ccaggactag aacattttaa aaatctgtac ttgacggcct cttcagcaaa ctaaaagtga 396840 tttgttctgc tggttttccc agtatcaaag caagcaggaa tcttcagatg tattatttta 396900 tgttacgttg tttggtttgg tttataaagg tgctattgtg ccatggtgtg aagaaaattt 396960 ttttttaaat gagtaccaga gtaacttgtt aaccatttcc tgtatagctt tctaagactt 397020 ttcactgcat attgacattt atgttgatgt gtatggagaa atgtcactga acatttcatt 397080 gagtttttct cctgtgtatc ccaaggcaga actttcttaa aagaaacaca aaaaatcaaa 397140 tgtaacatat taaattttat ttctgccttt gaagaaatat tttaattggc ttatgtattg 397200 tggatttggc catcaactat tataatgtat agaattaatt aaaaataggc ttaaatcaaa 397260 tatattaatg taattgtgaa aattcctatg aggtacagta tgcctaatct ttattaagaa 397320 atttaagact gtttcatcaa agaaactgaa gaagtttaga agtaaaaaag atatatagat 397380 gttagctctt ctgattacct tggctcaatg ttttcatgct tttatcttca acaaaaactg 397440 ccaccagaag aacacaggca taagtcatat gatgcagcag aactagcttt taaaataact 397500 gcttgattac tgtttagaat atagcattag acaatacatc atagatgact cctgaaatca 397560 cttttttggt cacacatcaa catctgtggg aggtacaagt ttattttgat ttctaaaaag 397620 tgaatgtaat aactggatgt tttcttttca tctttcattt ctgagaatac aaggatacgg 397680 attagtgtca tgcatttaca atttcacatt gtgggatgta cagctcttac aggtgaggaa 397740 tatacttgag aaatagtcat gtatataaaa atattgtgat agaatgatgc tcccccacca 397800 aagatgccta acatcctaat tcccaaaact tgtgttatgt tacattccat gggaaaaggg 397860 aagtaagggt gcagctgcag ttaaatgacc ttgaggtaga gagtttatcc tctattatcc 397920 aggtgggccc aaactaatca tatgcatcct taaaggcaga agaccttttt cagacatagt 397980 cagagggagg cgtgactaca gaagatggcc ggagagagtc tatggtgctg aacttgaaga 398040 tggggaaaag ggccacaagc caagaaattt cggcagcctc tgaaagctgg aaaaggaata 398100 ataataataa ttttctcttc agaggcttct gtataaatgc agtcctgccc accttcattt 398160 agttcagtga gactcaagtt caactcctaa ccaccaaaag tataagatat aaataaatgt 398220 gtgttgtttt aaaccactaa gtttgtggca gtttgttata gcagcaacaa gaaaacaaaa 398280 taaatatgaa caagatttag ccttttcacc ctccatccag agacaaaact ctcataatta 398340 tatttttgaa ttgattttgt gagaatatac tcctaaaaac aaaagaaata gattttgttt 398400 gcagcataca ttaaagtact ccagagaaat cagagagcca gtagaagatt agataaagta 398460 gatagataaa tagattgatt tattatgata aatattattg atttattatt gatttattat 398520 agataaatag attgattatt atttattagg aaggtcaagc agtcccatga tcatttccct 398580 acaagctgaa ccaggaaagc tggtggtgcg agtcagcctg agtctcaaga tttgagaacc 398640 aggggaccca gtggtataat tcccagtcca agttccagtg cttgagaact ggggggccac 398700 tagtgtaagt cctagagtcc aaatgtcaga gaaccaggag ctgcgatgtc cattgcagga 398760 ggagacagat gttctagctc aagaagagag aatgaactca cccttcctct atgtttttgt 398820 tctatttggg ccttcattgg attggatggt gtgtgcctac gttgctgagg gccatcttgt 398880 ttactcagcc tactgattta aatgctgatt tcttccaaaa acatcctcgc ttcacagaca 398940 catccagaat taatgtttca ccagctatct gggcatccct tagccagtca agttgacaca 399000 cacaaaatca tcacacacaa taaacagact ataaaacaca gttgatttcc atgttgacct 399060 attgagggaa gttagccttt atattgaatt ttattcaaca tgtacaagaa atgcttaatt 399120 ttattaggct aatattataa caactgtaga aataaatatc taattgatca aaaatgccct 399180 ttagcaaagt aaattggtct tgaagaatag agcaatcaca taaaaataga acttaaaaat 399240 tccaagtagg tttgaagttg atcgatataa gcatcacgct cctcctcgtt atgctgctat 399300 attttgtgga acacctacca cagataagct gtctgattta ggagaaaaaa attaatgtca 399360 ttcaccacca acagaaatgt gcttattctt tcaaaatgat tattgttgct gaaagtacaa 399420 atgtattgta ttcagagttg ccataaccac agtaaggagt tatgttgcat gatgaatgtg 399480 tttttttatt agaaaaacca agaaaaggaa agtttgccat agcatttcgc tgtgtaaatt 399540 agaatcagtc tttccattgg gtctggaatg tctgaaatac tttttttcct aatttgagta 399600 atgttttgtg atcataggtt actcttacac actatagcct tggatagagg tggttcattg 399660 ttgtcaaacc ataaagcaca cgaacagtaa tggtacccag aaaagaataa atatttcaga 399720 ggtttgtgaa aaatacaata agtacatttt agtttgttcg tggtctttac ttatcctaga 399780 ccttttacaa ccaaaatgag tcatgggact tttagaagga aattgtcagt gttaggtttt 399840 gtgatggtaa tgcagcaatc tccaccttcc atgatgcagc ccatgcttgg gtatgagact 399900 gtaaggagtc gagtttcatt cacctacatg cccaacctta gcctgattag taaatcctcc 399960 accctgagga agaaatgttc attggtgggt tccctacagt gacccctgtg ctgctaggga 400020 agggatctca tctgcatccc acaccatctc tgccagagca tgacagaata agcacagcac 400080 aggaacacaa ggaggtgacc aagcgggagg gcaccttggc agacaggcta cctcatcagt 400140 agaggagaca ttggggtctt cagcatcact caatcctgtc tctatttgtg agtgtacctt 400200 gtcatctttg ctgcatttgg ggctggccct gtcattagta tttccccaac aggactttga 400260 aagtcatagg gatttatatt ttcattctta agtactattt ccaataaaag acttctagat 400320 ttcttaggga acatgtggtt gctctacttt aagttgaaaa cagatatgtt tatttaatgg 400380 tagtcagtag aattatttcc tttgagggga gagccataaa cctgagttgc tgagagtgat 400440 tcttaaatga aattcacttt gagacttggc cagagcctgt tctggccatt gtaaaccaca 400500 cactaaacac atttgctttt ttgctggttt taatattgac agaaacactg actgggaatc 400560 gctcttcctt aatgcagttg atccttcact tttttgcaga gggggccctg ggtgcttaac 400620 ggaagataaa ctggaaggat actgagtggg gtctgaccag caaagcactg tatgcagtaa 400680 agatttccac tgacaacatc caagatgggc tgacattcct tgtgcccagt ggccatagga 400740 ctggaccttt ccattggatt acatgacatg gccttagcag agtccacagt tgccttgatt 400800 gatgacaaag tcaagcagac aagccagcag gtcatttcag catgcaatga ccatcagtat 400860 ccattatttg gactatgtaa taatctttca ggaacactgt aaacagtggt attagaccta 400920 aataactaat atggttttaa taaacctaaa ttactattta aacttaaata gcttttaggt 400980 attcttgaca tcacttcttg atgtctgtca ggtaataagt tcccacgtaa gaatataaag 401040 ctaacgtatc ctcttaaacc tttgtttcca aaaccaagag cattttactg aaactctaat 401100 atacaggcaa gttgatccct cattaagcca tgtgttcatc ttaacagata tgcacatatt 401160 tttctaatac agaaaccagt ttcctagact aattgaagat ccttgcattg aaggtaatag 401220 agtcttatta tttgcattca gtgtgaactg taaaatccaa gtcattagag aaaacaagaa 401280 tatgcttctc tttcaaaaaa catcaagcat gttttatata gtcttagttg caaatttcca 401340 tagttactat gtagtgaagg ttttctgaag gagatgagga ttcttcagag caagggttca 401400 gttaactggc atctggaaag aaccaacctt aattctaaat cctaactgga ttttcagagg 401460 ccattctgag ggtagtagat tttatctatg accttgtgtg ccagatgttt cattttatgt 401520 tctcccttat ttacctgaaa gtgatgatgg gcaagggagg catatgaaat tagctgacta 401580 atgataacac gtgatcaact acaggcttca tagctgagat accccaaagg gtttaattag 401640 gatttcctgc caatctgaga tttggaaagt gatttgggat aacaaaacaa acacatggaa 401700 acagaatgtg atttaaagag acgactcact taagtcacca gtctccaaca gaacagaacc 401760 aatgttgcat tatcccagag tgaactgagt cacctaacag cccagaggcc agcacgcaat 401820 taaagcttct gaggtgctgt gatctgaatg ctggtgtcac cccagaattc atatgttgga 401880 acctaatacc caatgtgata atattaagag gtagagcctt ttgggaagtg attaagacat 401940 gagaactcca ctctcatgaa tgggattagt gctctcataa cagatgttga aggggctgcc 402000 ttgtctcttc caccatgtga ggatacagag agaaagtacc atcctggaag cacagaatat 402060 gccctcacca gacacagaat ctcctggggc cttattctta gattccccag gctccagaac 402120 catattttgt tatagcagcc caaatggact aaacagaaaa catagacaat gtagggcaag 402180 cgtaggtcag tgatagagaa gctttgaagc aggaaggaag aatgtgggat ggacagtgag 402240 tgaggcacat gtagggaatg gaggtagaca gcatcatcca gggtacatta caaatcccac 402300 catcatatgt aatctgccat tgttcagtgt gaacagtcac tgagcatcag aagaccttga 402360 tcctattccc ttctctactt tggagcaagt tacaacatca tgggcctcag tgttctcatc 402420 taccagataa gaggatcagg cccagataat tgtatcagtt cttattcatt ttgtaaatat 402480 tttatgctat gccccagttt ttaaaaatag aatatgtatt agtcagccat tactgcaata 402540 atgcagtgta acaaatagcc cctgaatcta aaagcatctc tctctcttgc tcatgggtgc 402600 tccaggtggc tggatattgg ctatgctcaa ccggtttagg ttggacttgc ctccaggtac 402660 cagattggtc cagattggcc ctacttgatt ctcctctccc ttatgctagt aagtatgtgg 402720 ggttttctct tctcaggcag atcacagcag tgtcagagac aagccaagcc acacaaaaac 402780 atttaaaacc tctgttccag acattctgct atcacgacct tggctgccag ttacatgtcg 402840 gactccaaag tcaacagccc tgacaagtgt acacctcata ccctcaggga atggcaaaca 402900 gtgggaaaaa tgatagattg gccacaatct agtatcctga gtctccagtt ttagttatga 402960 atcctctctt gaacatgttt tagaatattt caaagttgag aaaggaaagt agcccctatt 403020 aatgctggaa agacaaggag ggaaagaaaa gtaaaagcag cagtttttcc tctattattg 403080 caccttattc cttgtcttaa ggaaatcccc attttgcaca agattaggtt atttaagtgt 403140 ttttcttcac ttactttctt ctaaattatt ggtgaaaata ctaagttcac agccagaaag 403200 cttgacataa atgcctgttt gtcaactttg taaagtggat aggaatacaa atatgatgta 403260 gagctgctgt aaatctggta gaataattaa aactttaaaa tatttcattt catgtcactt 403320 gtaatcacta caactgtagg aatgatgtaa agcagagaaa ataggaccca tcttacatct 403380 gctagtgttt gttatgagga cattaccttt cctttacttt tttaaaaatt tcaccagtga 403440 aattatattg accaaatgaa aactcataga ttactaatgt gaatttacta tttaaaaata 403500 atgttgaact catattggac ataacaagtg atgatataaa cctagatttt attttgatca 403560 tgaaataacc tagtcatgag gagtaggact gtggaaacct ggcttcccca gcaggaacac 403620 agacgggaac acagaccacc atgaatggaa tcctgtaatc catctgcagc ttcaactctt 403680 taactcacaa tgaagccata tgaacattct ctttaattaa gagatgttac agttttgtga 403740 gatacaaaat actaccgaaa taaagaagga tttcaacgtc tttattgaca ctctactgca 403800 gcataaatgg atctaccaag tagggtacat tatgcagata catgcccata gcaatacaaa 403860 tgttaattaa aaccttgttt aagatttcta ttttggaatg agttagcatt tcatgctggt 403920 aaaagaaatt gattaagcga attacataaa ttagccaata ctcagaagat ccacatagcc 403980 ttcctgtcac taatatagat ttttatcaac acgatatgat ccacaggtgt gagagcaaac 404040 ataacaaagg aaataactaa gaaatctgta gtggtgattt ctgcatctcg ggaacttatc 404100 atctaatact ttataacaag aacagttata ctctctcctc tgctattttg tatgcttttg 404160 tttcatgtcc atccacacat gcatacacat gaacacatgt accggggaag agagacaagg 404220 ttcacagatg tatcctgtat tatttccttc attaaggggg catgttccag ttggagagtc 404280 taaacattaa taaaaaatta actcggccag gcatggtggc tcacgtctgt aatcccagca 404340 ctttgggagg ccgaggcggg cagatcatga ggtcaggagt tcgggaccag cccggccaat 404400 atggtgaaac cccgtcttta ctgaaaatac aaaaatttgc cgagcgtgat ggtgtgctcc 404460 cagctattca ggaggctgag gcagaagaac ttcttgaacc tgggaggcag aggttgcagt 404520 gagccgagat cgtgccactg cactccggcc tgggtgacag agcgagaccc aatctcacca 404580 aaaaaaaaaa aaaaaacaaa aaaaaaatta ggggtcttaa tttgtatcat attcttttta 404640 taaattattg aatacattgg tagtacatgt ttattattaa aaggtagcag atacctttta 404700 aatataaaaa aattaaattt aaaaatattt aaatttaaaa aactagtaaa ttttaaaaaa 404760 taaaatcact ctgatgtcac catgctaaga tggatactgt gaccattttg acctcaacat 404820 ccagacttct ctctacacat atgcatgtaa atgtatatat aagttatata cacagatatt 404880 ttacatatat aaacttaaac aggattgtgc agtgcctaac attttataat gtactctttg 404940 attcaacaat atatgatgaa ttactttctg tactaagaaa catttttagg gaaactcatt 405000 ctttcagcaa atatgctcgg tttctttcaa tataccccct tggatgaagt tgtaattgtt 405060 tggttgtctt cataacctct accctctgga tctataatct agaagagaag ataaacatta 405120 gttaagtaaa caaacaagtg gatttcttac aaatagtaag aaatattctg aaagcaaaat 405180 aaacagtgtg caatgaaaaa gagcagtgga agaatagaag catgaggagg aaatggagat 405240 gagttgccaa caaactcaga aatgattcca tcatggggtc ccatggcaca aggatcctga 405300 gcagagggca ttggtcagcg agtagatggg aaaagatgca tgcacagaag cccagtgagc 405360 taagaaggaa ccagagaaat aagtctgggg ttcatccagg gcttggtagg gcaggtcaag 405420 ggtttaaatt ttatcctaaa gtttgagtat cttttagaca agagaaggaa atgatctatg 405480 tttggaacca gaagttcatt gatgattttg gcaaaaggat gcttagaaga agtaggagag 405540 aggtagccaa tttgaagggt gaatggtttc ataaatttat ggtgagggat ctgccttgtt 405600 aatccttctc atattgtgga atatttagca tctattgtct ttggtaccaa aacaaaactg 405660 aagagaatga tggtaaatat ctatatcttg gataactaag tcacaatgaa taatcctgct 405720 tgttagaggc acatgacaac tcacacatgg tcaacgctct atgcttattc ggcctccagg 405780 gagctagacc aagggaaaga cttacaagaa gactacagga tggggttgag gggtgaattt 405840 cagggggcta aataaacaac aaggctctgt cttcttgggt catgtcttcc ttggtcggct 405900 ctcaagaaag atgatcctgg cacttcctcc ttcttggaac ctgggctcta gggtctagat 405960 ctggtctact tggcactcag agacagacac tcccttttcc ttcatattct atgtgtttgc 406020 ctcagggttt accatttctt gtccacagac tagtagaaac tgaagatcca actgagtaag 406080 cttggggttg ggggaaagaa gggctgaata ggtcccatag cctgcatcca gtgcagaccc 406140 caaacttgcc tgaagtccat taagagagtg tcctcaaagc tccaggtggt ccattctaat 406200 aacattgatg ataactgtat taataatagg actagctaat acacactgta agtgctgttc 406260 aatttacata tgtcaactca ttccatccac tcagcaacct catgtggtat aggtcctgtc 406320 atatggggta gccctgaggc tacgttgctc agtgtcacac acagccaaga ctcatgtcac 406380 acacagccaa gactcagacc tgggcctttg gacttcggag tctttaacat ttgtgattac 406440 ccttcttcta tactgtctct ttccgtgtct gtaagtgctg ttcagtttcc acatgtcaac 406500 tcattccatc cactcagcaa cctcatgtgg tataggtcct gtcatatggg gtagccctga 406560 ggctacgttg ctcagtgtca cacacagcca agactcatgt cacacacagc caagactcag 406620 acctgggcct ttggacttcg gagtctttaa catttgtgat tacccttctt ctatactgtc 406680 tctttccgtg tctgtaagtg ctgttcagtt tccacatgtc aactcattcc atccactcag 406740 caacctcatg tggtataggt cctgccatat ggggtagccc tgaggctgtg ttgctcagtg 406800 tcacacacag ccaagactca ggcctgagcc tttggacttt ggagccttta acatttgtga 406860 ttacccttct tctatactgt ctccttccat gtgtctctct ggagaactgc cactaggttg 406920 aacaatgagt cagatgttca aagggctagc atcatggatg ctgatcaccc aaatgctatc 406980 tcaccatggc cactgacatc attaatgtgc agatacatgt tcctacaact cattcagaag 407040 acccaggttg ctttacagtc acaaaatact tttttgtaaa tactgtaaat tgttgaggac 407100 attgatcctc cctgatttgg actgaggcac agagcattgg gaaggggtcc agaaggtgat 407160 atggtttggc tatattcaca cccaaatttc atcttgaatt cccatgtgtt gtgggaggga 407220 cctggtggga ggtaatttaa ttatgggggc aggtcttttc catgctgttc tcgtgatctt 407280 gtgatagtga ataagtctca tgagatctga tggttttgta agggggtgtt tccctgcaca 407340 agctctcttt gcctgctgcc atccatgtaa gacatgactt gctcctcctt gcctgccatc 407400 ataactgtga gggctcccca gccacgtgga actgtgagta aattaaatct ctttttcttc 407460 ccagtcttga gtatgtcttt atcagcattg taaaagcaga ctaatacaga aggaagcatt 407520 gggctttagc atggctaggc agctccaatg tgtgcatggg actcagatct cagccacttc 407580 tgtctgaggt tccgaataca tgcttcctaa gtactcagtg ctgaattctt tctgttcaaa 407640 catctgaagt gttgctagtc ctacctttat agaactatgt ttcacttaaa tctgttctac 407700 ctttaacttg actttctgac ttcactccag ttccactgta ttaataactg aacagtggga 407760 tccaggcctg atctgcactg gaataacatt tttgcacagg gatcttttaa aagtgattta 407820 agttctgatt ctgttttgcc tgtgtatatg ttgtggaact aatattaact aatttattga 407880 gtactatttg caagacctat catagctgtt ttgtgtctag tttctccctt aatcctcaca 407940 acagctccat gatacaggag gtaatattaa tattcccatt ttggaaatga gtaagctagg 408000 acccagagag gttcagcaat ttgcctaaat atgcacagct aatgggtggt aaacagggat 408060 gttgcttgca cctatgacaa tggtgcaata gaaaagggta cttctacttt atgatacctc 408120 actttcatct gctgaaaaat tattgaaata tactggtttt ttaagaacat gccactctat 408180 ggctaccttc cagaaaaaaa aaattgtaaa atttataaat ctaagatgtc gatattggca 408240 gtgtgcttgg catcccctag agtgtgtagg ggtgaaatct gtgaatccaa ctccaggaac 408300 caagctctca gcatgtatgt tacagtgcct cgtgagagat gaaaggtctg ctgtttttca 408360 aaaggtgcca gaagacaccc tcattttgga gagcaaaaat aaattatctc aatcagtcct 408420 cattccttat gttgttagca tcaaaagaaa gctttttctc gggccaacat ggtagctttt 408480 actcagagac actgtgtgcc tattaccagc aatgataggt ccaacaacta aatgttgatg 408540 agaccttgga ccttgaggtt ggccaaggcc gtgctatgat tgcaagattc aatttggtgc 408600 catggtttgt gaggcttaca aaagtgtata atgttcattt gctttatgtc ggattattgc 408660 actttctcat ttatttaact ccttcactta ccactcattc attcattcat caacccaatc 408720 attgtttgaa agcctactgt atatcaggaa ctgttctaga cctccaagat accaagatta 408780 acataacaca tgatcgttgc atctatggag tttatattct agaattgttt tactttggac 408840 aatatcacaa gctctatttt attgagtgtg atcattaaat taggatacca gatcttaggg 408900 ttgaaaaggg tctcaaaaat tatctcatct ccttcatttt aagctcaatg acaagtggca 408960 tcctcaaggt cacacagtct atggcagaat acagactcga tgctgtgtcc ccagactcct 409020 ggtcctgggt ctgctgctac tgccagaaac ttcattttaa tcaggtgttg gtgtcagcat 409080 acacctggtg gcgagcaaga aggcagcttc aaggtcaata cagggtagga catagggtca 409140 gactgagacc tgtgaggcta tgagatgaac attgctgcaa gccaaatctg agagcttggc 409200 ctcaagggcc tgactgccag tgccccagtt ctggctcttc ttcttttttt cttttgtttt 409260 tttgagacta agtttcactc tttttgccca ggttggagtg cagtggcagg atctcggctc 409320 actgcaacct ctgcctccca ggttccagta attctctgcc tcagcctccc gagtagctgg 409380 gattacaggt gcccaccacc acgcctggct aatttttgta tttttagtag tgacggggtc 409440 tcaccatgtg ggccaggctg gtctcgaact cccaacctcg agtgatctgc ctgtcttggc 409500 ctcccaaagt gcagggatta caggtgtgag ccaccacccc tggctggctc ttcttttaag 409560 gtctgtgaac ttgagtaagt tatttaacct ctctgttcct caatgcctcc cttgcaaaat 409620 agagataatc ataaagctgg tctcacaggg ttttcactaa gattatgtaa ttgctcatgg 409680 gaatcttcat acttctccca tggttggtgc ttggtgaagc ttggctattg ttattactat 409740 tattagtagt agtattgcct ctgtgactct gtggacacct tggtggagcc ccgagcttag 409800 tttcttgaat cccccttgtg attcttagag tggcaattcc cacagcaagt ctccccttgc 409860 ttgaaaatgg tcctgaatgt gacccaaaca gtgaacatgt cacagagcct gtctacaccc 409920 cttctgaaga aagccgcctg taggtcatcc atcaaaataa tcatttaatt tcacattcct 409980 gattttgatc cttttcagga atcctgaaag tgaattccta ccttttcagc caaatgtaat 410040 ctacttcctg tgttttcagc caccacatct gattataggt atgtggcata tctgcagtaa 410100 gtgtaacaca ctatttccca aaaagaggcc ataactcaca tgcagaacca aatccttttg 410160 gaaaacagta tatgcccttc ccagaaaccc aaaatttaca ataacttatt aaacaccctg 410220 gagggtactg aggtaataaa atctaaattc tataaattga ttgtttcagc aagaaacagg 410280 cttccaagct ggcttcatgc atgcaggaac tctatcatcc caaaagactg tgctcttaga 410340 aggacccagt gcttgactta atgcgctgct gttttcgtct tgaaattctt aaccattttt 410400 taacgagggc ggcctagttt cacttggcga gtccttcaag ctttgtagct gttcctgaca 410460 cccctcatca tatcccacag aactggtgtt ctgccaaaca agtctcaggt gagacccctg 410520 ttgtctgttt tctgtcatct gggtcaataa gagacaaact cagtggagag ttaagaatct 410580 atcttaattg ttaaaaatat gcaccagatt tcctaatcta aatgtatgtg cacacaccac 410640 tagatgccag catgaaccag agctgctgaa ttcctgttca gagagaattc agctcagcct 410700 tgttttgaga agttctaggt tcttccccca gaggactatg atggggcaac ttaaacccga 410760 aaatactgtt caagtgtaat ttgtgtaaac taaccatctc agggggaaat ttttccatat 410820 taatctttgt gtaatttctg aattataaaa ctatttttag atgaagaaat acatcactac 410880 aattgataca gagacacttt aatttaattg gcacaaaagt atgttaaaaa tattccacag 410940 tacagatgct ccctgactta tgatggggtt atgtcctgat aaactcatcc taaattgaaa 411000 atatcttaag ctgaaaatgc atttaatatg cctaacatat tgaacatcat acttagccta 411060 cctcaaacac tcagaatgcc cacattagcc tacagttggg caaaatcatc taacaagtcc 411120 gtcttgtaaa atgtgttgaa tgtctcatgg ttgtttttct tgattccatg gctgactggg 411180 agctgtggca ccctgctgct gctcagcatc atgagagggt atcatatcac atatcgctag 411240 cctgggaaaa gatcaaaatt caaagtatgg tttctattga atgggtatca cttttgcacc 411300 agtgtaaagt gcaaaaatcc taagtcaaac catcggacag gaactgtctg tataggtaaa 411360 gggataggca tagagatcag tgaaactgaa tagagaaccc agaaatagac ccacacaaat 411420 atgctcagct gatttttgac aaaggtacaa aagcaattca aaggagggat gatagtcttg 411480 tttccataaa acagtacaag agcaattgga tatgcatagg caaagaaatg aaccttcacc 411540 taaatctcat agcttttttt tttttttggt agatacagtt tttaaatttg tattatttat 411600 taatttttaa actttcattt ttaggttcag gggtacatgt tcaggtttgt tataaaggta 411660 aacttgtgtc accagggttt gacataaaga ttatacaaaa attcactcag aatggatccc 411720 aggcttaaat ctgaaatgta aaactataaa atttgttgtt ttgtttgctg cataatacca 411780 actaaattaa acaaacatta gagaagttga aagaatgcaa ggatttaata aatcatctag 411840 caacaaggct gcactttgag cagctgcggg ctcacaggat tttcctttaa gccaagagga 411900 ttccgcttgg cagctgcggg gcaaggccac tggtgtgcca cgccacctca caccgcagcc 411960 accagacttc agaactggaa aagggtgatt ccggggtaat ctctgccacc tcctgcctaa 412020 ggagagatct tgtccgctcc ctaccatttg tctatcactg atcgattcca ttattggaaa 412080 actttctaga gcacttgttg gggacaatgt aggtctttca ggataggatg gcctgtctca 412140 aaaggtcatc ctagggccat gttctttctt cgtttcctac ttgtcccact caacaaacaa 412200 ggctaattgt ggctacctct caaggctgtg aggaaataat cattcatagc tgaaatgggt 412260 cttgtagata tcagtgattg tacattctcc ccaatatctg gatttagtgt ctaatcgggt 412320 gtttttttgt gacacatgtt gtattgataa tgatcaatat aggtttattg agaataacaa 412380 ataattacac aaattcaaaa attattttcc ttcattatac acagggcata tcaggactgc 412440 tttttgcaat tataattgag gtgctgctgc attattttgt ttaattattt ccacctgatg 412500 gcctgattag gaaaattgct caccttgttt tcctagcata atgcaccatt atgagaagca 412560 attactgcag cctgtgtccc cagcccccag gctgagctac catcctacag tggctaccat 412620 cctgtagtgt gcatggtctt gccagcgtcc agatagagtt tgagttcagc catttgattc 412680 taagcctaaa ttcaaataat ctgtttttca agaaagggtt ttgtttaact ctaagacact 412740 ggaaaggtga tgtgtgattt ctcatttgct gatgtttgac gccgttgttg gcgtctccgt 412800 gttggcatga gcacactgct ctctgcctcc atgttgtgtg ttcacacctg ctctggctgt 412860 acaagctgaa agggttaaac gtatcctgtc ctggtggact ttgtgtggca ttaatgtttg 412920 agaataagtg tgctctgcca ccacgtgatc atgtgtgtgt aaacatgatt aaaaggaaaa 412980 tggtgatgac aaggctggta aggaaagttg tggaactgca ttaggacagg cagccatgcg 413040 agggccagaa tgaaataccc agtttggaag aagaaaggcg gtctagatgc cccttggaag 413100 tcactggccc ttcccaggtg aaaccatgtg gtgtggactc cagctgcctc aggtgacatc 413160 gcccaacgca ggtgatatta tccacttcag atgacatcgt ccacttcagg tgaaatcacc 413220 tacctcatgt aacatcatct acctcaggtg acattaacca gctcaggtga tatcttctac 413280 ctcagatgat gtcatcacct caggtgacct catccaactc aggtgacctc atccaactca 413340 ggtgacatca tctacctcag gtgacatcat ccacttcagg tgatatcatc tacctcaggt 413400 gacatccacc tcagatgatg tcacctattt caagtgatgt catccacttc aggtgacatt 413460 gtgcagtctc ttgctagcca tttccctaaa ctggaagaga gatagaaaaa aataaatcct 413520 acctctgcca tccgccaaca gtgtgaacaa atccaactct ctccaagctt ttgttttcat 413580 tccttaataa ttgaattata ggaaaatcat cttcaaagaa aaatgcagtc ccgtgcaggg 413640 gttggagatg gggccagtca aagcagaagg agcccatatg aacaggcaga tgttatgctt 413700 tctgtgttgg tcccgtgcag ctggtgcctg cctgctgcag gtgctctttt tttttttttt 413760 tttttttaga cggagtctta ctctgtcacc caagctgagt gcagtggcat gatctcagct 413820 cactgcagtc tccacctccc gagttcaagc aattcttctg cctcagcctc ccgcgtagct 413880 gggactacct accatgcccg gctaattttt tgtattttta gtagagacag ggtttcaccg 413940 tgttggccag gatggtctct atcttctgac ctcgtgattc acccacctca gcctctcaaa 414000 gtgctgggat tacaggcgtg agctaccatg cccggctcat tttgacaggt atattaatga 414060 atgaagaaga aatgtgactg attttttttg tatctgtaaa ttgcttataa tttgaaacag 414120 atagaaaatg gttacaacag aaatgttggc tttcacagct gggaaagaag aacaaacgag 414180 aagcgatggg tcaacctggt taagagagta ggtttcaggc tcagacttcc ccaggtgcaa 414240 acccagctca gctaccgtgg aacctgggca catgacttca ccctctgggc ctcagtttcc 414300 tcacctgtat gacagagatt atctcaccta agccatataa ttgctttgag atttagtaag 414360 ttgatgcatg tcaaaatgaa gggcactgac tacttttttc ctttactata tctattcata 414420 gctcatcttc tggcttcgtt gatgaaaagg ggcatctatt ttagggcaag ataattagct 414480 gtgtcctata tgataggctg aataatgccc cattcaccaa agatgttgaa tccgaagcac 414540 taggaacctg tgaatgttac tttacgtggg aaaaaggact ttatagatgt gattaaattg 414600 aggatctttg gaagtgggga ggatatccta gagtgtttga gtggcatcta aaggtaaccc 414660 caagggtcct cataagacag aggctggagg gccgaagtgg gaggtggtgg tgtgaggaag 414720 gaagtggaga tctgagtgat ggccaggagc tgagaaacac cgcagcctct ggaaggtgga 414780 agaggcaagg aacagattct ccactgaagc ctctggaaaa aacagccttg ccaacacctt 414840 gattttagcc ttttgactat cagaagaaga agatatttat ttatttattt atatatttat 414900 tttttattat tatttttgag gcagagtctc atgctgttgc ccggactgaa gtgcaatggc 414960 acgatctcgg ctcactgcaa cctcctgggt tcaagcaatt ctcctgcctc agcctcccaa 415020 gtagctgaaa ttacaggcac ccaccaccat gcctagcgaa tttttttgta ttttttaata 415080 gagccggggt ttcactatgt tggccaggct agtctcaaac tcctgacctc aggtgacctg 415140 cccgccttgg cctcccaaag tgctgggact acaggcataa gccaccacac ctggccagaa 415200 gaatacattt ataagagaat cagtttctat tgctttaagc cactaagttg gtggcaatcc 415260 attacaatag ccacaagaaa ctagtacggt tgactctaga aaaatgcagc agttggggta 415320 ctgactgctc aggcagccag aaatctgcat ataacatttt actccccaaa acttcaatat 415380 agtagcctac tgctgactgg aagccttact gataaacagt tgattgacat attttttgca 415440 ttatatattt tagatactgt cctcttacaa taatcttgag aaatgaacac attattcaga 415500 aaatcataag gaataaaaaa atatgcttac tattcattag gtggaagtgg atcatcataa 415560 aggtcttcgt cttcatcatc ttcacattga gtaggctgag gagtcataaa ggtctccgtc 415620 ttcatcgtct tcacattgag taggctgagg agtcataaag gtctttgtcc tcatcgtctt 415680 cacattgagt agttcattag gtggaagtgg atcatcataa aggtctttgt ccttgttttc 415740 acattgagta ggctgaggtg tcataaaggt ctttgtcctc attgtcttca tattgaatag 415800 gctgaggagg aggaaggggg agaaggattc atctcaggag gggcagaggc agaagaaaat 415860 ttgtgtatca gtgaaactgc agaaacttgg gttgttcagg ggccagttgt acaccccatt 415920 acatgagatt tcaattagtt tagatggaag tttttctgaa aatctttgca taacatcagc 415980 ccttttaaat gagagataat gaagatgtgg caggataact atttttgttc tatttatctt 416040 cgcagagatt ctgtataaca tagagatgct ccatattctc agactgcttt gcttttcgaa 416100 ttgctggttt tcatttgtaa gattttgcag ttgtttttct ccctctccag ctgtctcagt 416160 agcggcttct ctctcactgc tgcctccacc cttaccacct tctagttgta cagctagaga 416220 agaagaatgc cggtaaagat gtgtgaagca cgtgctgtgt gttctgcctc aagtgcgtcg 416280 cacacggtat ctcatttgac tttcccaaaa cctctgttta cagattgtga caatgaggcc 416340 caaagaggcg aagccggcag taaagctaca caggaggaag atagacagga gtccagcggt 416400 agagccaggg ccctgaaaac cactcttcac tgttgtatta attggggttc tctagaggac 416460 agaactaata ggatagatat gtgtgtatat atatagggga gtttattacg tattaactta 416520 cacaatcata ggatctcaca agaggctgtc tgcaagctga ggagcaagga gagccagttc 416580 gagtcccaaa actgaagagc ttggagtcta atgttcgaga gcaggaagca tccagccagg 416640 gagaaagatg taagctgaga ggctaggcca gtccttgttt tcatgttttt ctgcctgctt 416700 aatatttgct ggcagctgat tagattgtgc ccaacaaatt aagggtgggt ctgccttccg 416760 cagcccactg cctcaaatgt taatctcctt tgtcaacacc ctcacagaca cacccaggat 416820 caatactttg tatccttcaa tccaatcaag ttgacactca gtattaacca tcacagctgt 416880 ctctacatca acttgtagaa aacattgtgt tgctaaaact gtacctaaaa tagcactgag 416940 ctaggctgtg agtgaaggta tgaagattaa ttctccatca aatgcaatgt gcagagtgct 417000 ggattttagc aagaggtgac aagcagcgac cagccccctc tatgtgtgtg agggtactct 417060 tcagattact ggatattagg aaaaattatt ttttgttcat ttgtatttta cacaaggtct 417120 taatgacttt taatagagtt gctctgaagg ctcttttctt ggtcattttt aaggagatat 417180 tagtaacttt aattcctatg acccaaaatt gcattaagga aagaggtcat gtcttattat 417240 attttgcatc tcaccatctg gaatagcgcc cagcatagaa aaaatccaga aagtgtttat 417300 caaataagta aaataagtaa catattctgg agtacttaat aatagccagc acttaatgag 417360 tacttactgt gtgccaggca gtaagccagg tgctgtttgt ttgtattaac tcatttaatt 417420 ctctactgac attataagga cctgaagtac aagggcgttt aacaactttc caaactacaa 417480 gtggcagccc tgagctggga gcccaggcta tctgggtcca cagttcacac tttaaaactt 417540 gatgcaggct gggcttggtg gctcatgcct gtaatcccag cacgttggga ggctgaggca 417600 ggtggatcac ctgaggtcag gagtttgaga ccagcctgac caacatggag aaactccatc 417660 tctactaaaa atacaaaaaa ttagccaggc gtggtggtgc atgcctataa ccccagctac 417720 tcgggaggct gaggcaggag aattgcttga actcgggaga cagaggttgc agtgagccga 417780 gatcacgcca ctgtactcca gcctgggcaa caagagtgaa actctgtctc caaaaaaaaa 417840 aaagcacaaa aaacttgata caatactgcc tctctaaagt ccataaatgt aacatttaaa 417900 attatatttt gcaaaagaca ttttgcaaaa aattggaaat ctgcagttgt gtttgcaatg 417960 aaaaacatta ttatattttg ttggtgccat ataataacat tgaaaatttg gatacaactt 418020 taagcaccat gggagagcaa agattatgtc ttgttgccag ttcatctccc ttgcctagca 418080 agctcagagc ctcctataca gtatgtactc agtagccatg tgggggctgt caaaagtgcc 418140 atgctgcaag gggttacagt gatgcttgaa aaagtaccta aaatgcaaag ttttcataca 418200 ctaatgcaac tttcattata ttttatattc ctaaatgaaa ggagtcacat gaaatggtgt 418260 gtgtgtgtgt gtgtgtgtgt attaggtcgc tgtatgataa aggaagtaga acgatatcat 418320 gtcagtggtc agctgggaca caacatgcct atgcccaggg cagcggccag ctgaaacaca 418380 cagccccacg acactaaata tggatatttg ctctagaggg aattagtaaa tttgcatatc 418440 ctgtttggag atagttctgc cttctcgttt agtttttgct tgtcttagac tctataaaag 418500 actcataact gcagttcaac aattgataat aaaatagtat ttgcagcagt gtgtggtggc 418560 tcacacctgt aatcccagca cttttggagg ctgaggcggg tggattacct gaggttggga 418620 gttcgagacc agcctgacca acatggagaa accccatctc tactgaaaac acaacattag 418680 ctgggcatgg tggtgcatgc ctgtaatccc agttactctg gaggctgagg caggagaatt 418740 gcttggaccc gggaggcaga ggttgcagtg agacgagatt gcaccattgc cctccagcct 418800 ggacaccaag agcaaaactc catcacacac acacacacac acacacacac acacacacac 418860 acacacacac acacacacaa agtatttgcc ctcatggtca cacagttgag gccagcgcct 418920 ttgttgggag aatgaagagt aagtaaatct caggtaaaat attagggtta agacagatga 418980 gctttggtgt tgaacatgcc aagcctaaat ttcagaaact taaaggcaga ttccccttca 419040 tagtagatca gactggacct ggactgtgag gacagacaag aaagatggag ctctcccaga 419100 gcgaagatga tacagtgtag cacaaagtat aatgggtcaa ggtctggaag aatttaggat 419160 caaaattcag ctgattaatc agtatcattt gggaaattcc ctttaaaaaa atggggcttt 419220 ctgcctcagt gctgatattc atccagaaca caatacttaa ctgacctcaa ctggatgaca 419280 tcttcaatca aagctcacag gaagacatag cagcaccagg ccacatgcgg caggcagccg 419340 tgagcatagc ctccctagct tgtgtctggt ttggtttgat gcatcaggat gagaatctgc 419400 agcattcttc caatgacaaa gccaatgggg cagcttatcc tctccctaac tctttccctg 419460 tgtttactgt gctgtagaga ttttgcataa agtgctgcaa agtgggtagc aataagggag 419520 ctgaggtttc attcacagag ggaaggccag ggattctgaa tgttgactgc aggtgggcat 419580 tgtgtttggc aaatctcttc tacttgaggt ctgaccttag ccttctagac tctgaaaaac 419640 gatcctgata ctgacccaga ttggaggggg tttggtaatt ctggttcatg gtaacaaagc 419700 tcccattaac ctattgaaca attgagtttg tcagtatatg aatggcccat gcccagggcc 419760 atggtcagct gggacacatg ggttcatgcc gagggccatg gtcagctggg atacacgggt 419820 tcatgcccag gacagtgatc agctgggaca cacgggttca tgcccaggac agtgatcagc 419880 taggacagac agccccattc caatgacagt ggtctggtca gctgggacag acaggtccat 419940 gaccagagca gcagtcagct gggccaccta ggcccctctc ctgtatgccc tgctcgctgt 420000 cttcaaggct cattgcagag agtgctgtgg ccagaaggtt gcttggtgag cctggaatca 420060 gaacactcaa gcttctggta tctcagacgg ctgacagcat caggtcccgg ggctgacacc 420120 tagggagctg cttattatac cccctgtaat aagtattccc acaaataggg atagtaccct 420180 tgcacactag attttttttt caaagtgtta gccaagtacc aatgaagaaa gagcaaatgt 420240 gagccaagat gacggtttgg gcttgactga ggagaatgac tgtggacatt gtcctgtgtg 420300 tgctgctcca accccccagc ccaaatgaca ccattcccat tgtcatgttt gctgtggtca 420360 ctagctggtg ctcctaggaa gcacacaaca aagcttgctg ggcctctttc ctaggctcca 420420 gccctttgag ttatgcctct gggaaagtat cttgtacttt tcttcatctc tcatgtcata 420480 gtactctcta gaacacttat cttttatgac attgacatct aaaaacaaaa taaatagtga 420540 aatgtggcct ttgacaactt taatattgcc atttacatta tgaaccttta acaatttaga 420600 atgtataacg agatgacaaa tttcctattt ctgaaagtag tcacagatgc atagtagtat 420660 agacacatag atgccgtgaa ctgttcccac agcaggcaac gtccactcgt gaaaatgccc 420720 atagaccacc tcgccaaatt actgaatggc caatgaaagg acaaatggag agaaaaggaa 420780 gcagcacagg ttttccaaca aactgtccat ggatcttgta aagtgacaac atttgtgacc 420840 attgtaggca gacccatcta tgcagcttct gttaactgtg acagcagtca ggctagttta 420900 ggaagtctgc ctcctgctta gctagcccca gggcacaagc ccctgacaat tgtgcctggc 420960 tttgctggat acagtccaga gtcggtcttt tcttccagtg ctaccaatgg agtagtatgg 421020 ggccagccac accctctgac cccaatccat gtgtgttcac aggtgcaaat ttaacaatca 421080 aacatgagat ttggagaagc tcttgattga ccagcaagca aagtgaaatt tactgaaaag 421140 tttagcttca ttgtccttta ttctgccccc tacaaaagga tattatatat agatagatat 421200 ccatatatac atagtttatt catgttcaca tatataacat atatagttaa catgtgtatg 421260 tttatatatg tttatggata cacatgcatg tgtgtgtgta tatacatgct gaaggtggat 421320 tagaaactat aagattggaa gtaaatatat tctttagaat tatactaaaa cagaaaaaaa 421380 gctgtatttt tgtttttaag tttatgaaat gaacaaggaa gagttttttt tttttttttt 421440 ttttggacac cgagtttcgc tctttgttgc tcaggctgga gttcaagcga ttctcctgta 421500 tcagcctcct gaacaactgg gattacaggc acccgccacc acgcccagct aatttttgta 421560 tgtttttttt tttagggggg ggtaaaaaaa ttcttattta tctatttatt attatacttt 421620 aagttctaag gtacatgtac acaacgtgca ggtttgttac atatgtatac atgcgccagg 421680 ttggtgtgct gcacccgtta actcgtcaac caaacaccgc atgttctcac tcataatttt 421740 tgttattttt agtagagacg gggtttcacc atgttggcca ggctggtctt gaactcctga 421800 cctcaggtga tccacccacc ttggcatccc aaagtgctgg gattacaggc atgagccacc 421860 atgcctggcc gggaagagaa ttttaatctc agctacatca ttatcttttt tgatcccagc 421920 attcctttat gtaacccaaa ccttggttct gttttggagt tgtagcctca ataactgtaa 421980 gagattaaac ttctgttgtg ataatttttg tttgtttttt gagatggagt ttcactcttg 422040 tcacagagag tgcagtggtg caatcttggc tctctgcaac ctccaccccc caggttcaag 422100 caatccttgt gcctcagcct ccagaatagc tgggattaca ggcacccatc cccatgccca 422160 gctaattttt ttgtattttt aatagagatg aggagattca ccatgttggc caagctggtc 422220 tcaaactcct gaacttaagt gatctgccca ccttgtcctc ccaaagtgct gggattacat 422280 gtgcgactgg cctgttgtga taattttttg tggaaacccc caggaaactc acacagctta 422340 tttagattaa agataagaaa gctatttcca gaatataatc tattcccaga atgtcatgtc 422400 ctcaggcata tcgttgttga acctttgatt atattctgga aatagatttt ttatctttaa 422460 tctgaagtaa attgtgtgag cttcctgggg attccataac atatgaccac aatagaagct 422520 gattctctca cagttctgga gcttacacct ccaaaattca ggtgtctgca gggccatgtt 422580 ctccctgaca gttctggaga ggtccttgct cacctcctgc ggcacctggc gctggctggc 422640 aagccttgct cttgttggtt tgtattatag acatcacgcc agtcacacgg ctggcttctt 422700 ccagtgtttt tacctcatgt tccctctatg ggtgtcagtg tctgtctcca tatttctcca 422760 ttctataagg acaccactta tattgaactg gcacccatcc taatggcctc atttaaattt 422820 gattatcact ataaagacct tatttccaag taaagccatg ttttgagata ctgcaggtta 422880 ggggtctgcc atgaattttg gggggacgca atttatccca tgacttctaa attagaaaat 422940 aaaagaaatc tgttttaaaa ggtacgtcat gctgctaggc tatctgcaaa ttaacagtgt 423000 tccaaatctt ggtattgatg tttgcaaaat ttaaaaatag gacaattcaa attttacctt 423060 cctgttttta gaaatcatat ttttatatta gcttatttat taaagtggaa aaccgatatt 423120 agctatatat aaaaagagaa aggataatag gaaagtgagg aaatataaaa ttttgtttgt 423180 aatatttctc taaatgttta tccagcatct ccctcttccc cacacccctc acagcctccg 423240 ctcttggatt tctgcccatt aagactgata gcaggaacat ctatgaaatg ccattcataa 423300 ttaattttgt tacatcactg atcatggccc acatgtgtta ctggtggatg gtatctgagt 423360 taccggcagc gaatccatat ggctctatag caacaccaat tcttgcctcc tcagaggaaa 423420 gaattcgacc aaggggtata aggcacaaaa agagactgag gcaagtttca gagcaggagt 423480 ggaagtttat tttagacagc tttagaacag gaaagaaagg gaagtacact tggaagagac 423540 tgaagcaggc aacttgaagg acaagtgcaa tctttaacct tgatcctagg actttgtagg 423600 ctggcccact tcaggtgtct tgcacccctt tcccatgact cttcgcttag gacgagcttc 423660 ccgcatgcgc agtgccctcc ttccccttgg gaggtgagca tgcgcagtgt gtttaggaag 423720 ttgtaacacc gtttacatac atgttctcaa tctctctctc tctcgttgtg gataatgagt 423780 cagttaaaaa ttagtaactg tccttgttaa tgaaaaccta cctacattaa tacaatactt 423840 ctgttcaaaa tattcatcgt gactcaaaat tttgggaatg aatatatttg ctgttaaaat 423900 gcttctagat gctcgcatat gccactgcct ggcaaagtca gaagagggta cataaattac 423960 ccaggcgata ccttctatgc cctctggact tttatgcctt gttagtgtct aaggttacag 424020 aaaaaagaaa tggaacactc gggttgccag ggagacatcc aagcctgtca acccctctag 424080 ctctaatagt gacaaatggt acttattaca tcaggactaa tttcattgga ttctgctcag 424140 ataaagatac ttaaccttta ctgataaaat tgtgtcgtta taattactta gtaaaagacc 424200 ttattaggca atagtattct atgtggatag acgaacattt tattgaggtt gattacctat 424260 tacattgatg gaatatttga atgtatgatt ttctgcaaga cctttacttc ttggaaaaac 424320 ctgcagcaaa gagattttgg ttttgtggct gcctcatatg gaggaagttt aaaaatgtgg 424380 tttttgcaag ttgttattga aaatccagaa aaacaacata tacatttttt aaaaaataga 424440 ctttacatgt caactttttt gttgttgtta ttgagacgga gtctcactct atcacccagg 424500 ctggagggca gtggcgcgat cttggctcac tgcaacctcc gcctcctgaa ttcaagcaat 424560 tctcctgcct cagcctcctg agtagctgga attataggca tgcaccacca tgaccggcta 424620 atttttgtat atatatattt ttttttagta gagatggagt ttcactatgt tggccaattt 424680 ggtctcaaac tcctgacctc aagtgatctg ctcacctccg cctcccacag tgctggggtt 424740 ataggagtga gccactgtgc tcggccacca acttttaaaa caaagctttc tatccaggca 424800 cataaaatta aaatatccaa atatgtcaac gaacctttta gacttttagg gtatatgccc 424860 tcgaaggcca agactggaaa taaattacat tttgaatgtc agttccatct gactggtagt 424920 gactgcctgg aatgcagaac tgagaaggat tctgaagtct tatctgtgct cactagaaaa 424980 gagtgtagta attgattagc aatgtctgcc atgggcatga gcaggacatg catcagtgga 425040 tatgctcata attgccatcc cttgtctaag tttatagaaa gatagcagtt gtgtcaatga 425100 ggcattcagt ttaaaagagc cttttctgtc tcctccatat gcattacatg ctcagagcct 425160 cctcattctc agtttgtctt aggcagggaa accacagccc tataggacat ttctcaaggt 425220 tggctctgta gacctcttct aagcaccctc ccctgcaggg cacctgggaa aagaaatgtc 425280 ctctcccaag gagctatttg tttcaacact gtcagagaga aagtcatgga gatatttgtc 425340 ttaaaatcca agtacttttt gtttcctttg tccattttgg tttccgcctc tcaggtgtta 425400 attctgctaa aatggtgatt gataatactg ttgtttatct ctcctgagag ccaaagatat 425460 gccccttgat ggcggaaatt caaagactgt gagaggcagt aaaagaaagg ctctgggaca 425520 gggttatttt tcaacataca cctcaaaaca cacagcgctg gcagctccta tgagagcaca 425580 tgtatttgat atccaaattt ttctagccta gtgtcccaca ccaatcccac aagcacaaat 425640 gtaattcttc aaaaaggagc atgctaagaa gtgccctgaa gtttgcagaa tgaactcatg 425700 cagcactttc tgagcaggct gggttcccct tgcctatgac tatgcttacc gaaggtcagg 425760 cttccctttg acaagacagg acaggtactg tatgcttagt ttctctcctc tgtctcacca 425820 gtttcggagg cgtgttcagg ttctaacgtc aggggtgagg tgaatccagg tgaggaatgg 425880 tggagtgaag gatgcagtga tgggcctgag ctgcaggcag tggtgatacc agctcctctc 425940 catggctctc aagtcttgaa cacacatcaa ttcctctgtc tttcttcatg gctgaaacaa 426000 ttgtcaggtt aacatattat ggtaaatata ggtgagaagg tgacactttt aagactatgc 426060 ctgaggctgt tgctcccagg cactctcctt attaagcttc tatattagtt taatattagt 426120 ttagtatgct gggtctgcca tcacaaagca cacacagtga gtggcttaca gcgaaagaaa 426180 tgcatcatct cccagttttg gaggctggaa gtctgagatc aaggtatcag cagggttctt 426240 ccttctgagg actctgagag agaatctgtt ccattccttg atcgtagctt ctggtcgttt 426300 gctggtaatc tttggcattt tgttggcttg tagaaacatc atctgatatc tgccttcagg 426360 gtcacatggc attcttgtat gtccgtttgt gtccaaattc cccctttgta taaagatacc 426420 aggcatattg gattagtgct cactctaatg acctcattca gctaatttca tctgcaagga 426480 cagtattctc aaataagttc acattctgag atactggtgg taggacatga acatacaaat 426540 tttggggaaa cagaattcaa cccataacac catagatact tggttcaaac caactctcct 426600 gaatcctgac cttcctgctt gctccataaa gtttgacttg attccctcag ttttcctcag 426660 gatttcagtg gcttccacct tttgaaaaca aaagctgatt ttctgaatta taaataccag 426720 gcattctgat tttagcaaat gtagaggctt ttgatacgga taaagaaaag ataaacgaaa 426780 tccagaaccc aagtcataga tcttgagtca tacactcaag cgcagattca tgtcaaactg 426840 tttcctttta gtctttcaca tatatctata gacttacttt aaaaatgaaa attggcattg 426900 tttatatata atttctcacc gggcttattt taccagtgtt acattgtgat tatctcatca 426960 aattattcaa tattcttgaa aatatgagtt ttcttgagct acaaagctat cacaattggt 427020 atcctgttac tgtattttgc tttgtgccta atttttttgt tttattatat tatcagtccc 427080 ttaatatgtc attttcataa ccactttttc tctaatgact caaaagcatt ccttcagtat 427140 ttgttctaat gattactctt aaattttata tatacttatc caaacttttt tataggtgta 427200 aaagccaaga ataaaaaagt atctatgggt ttcttgggta taaagtgggt aattttatat 427260 aattttaatt ttttattctt tctagtcagt tccttgttcc aataacaata atgtgagact 427320 ttatacatgg tgatgatgat gctgacaatg atagaattga ttttaggttt catgaccata 427380 tcatatcttt tgacataatt tatgtttagc tgagattaag ttatgcaata cattcttgag 427440 ttcttttgat aggctagaag atgtatctga gtaatttttc ccagaaatta tatgtgagtg 427500 gtatagctgg tgagaccttg aatctgggtg aatctctttc tttgccctca tatatgaaag 427560 ataagatggc tgggtataga agtttgctca gagaggtgca tattctgttc cattgacctt 427620 ggatgatgaa acccagtgtt ttcatgtata aattacctgt tttaccagcc tgcacagtta 427680 gaaaactttc tttaccccta tatttcaaaa ttctttgata tatgtttcag aattatttct 427740 cttttaaata atatttcgga tacttcatga atttttctat ctgaaaacac aggattttat 427800 gaactcttga atacatttaa aaaatatttt ctgggctggg tgtggtggct cacgcctgta 427860 atcccagcac tttgggaggc tgaggcaggc ggattatgag gtcaggagat ggagaccatc 427920 ctggctaaca cagtgaaacc ccatctctac taaaactaca aaaaaaaaaa aaaaagctag 427980 ccgggtatgg tggcgggcac ctgtagtccc agctactctg gaggctgaag caggagaatg 428040 gcgtgaaccc gggaggcaga gtttgcagtg ggccgagatc gcaccactgc actccagcct 428100 gggtgacaaa gcgagactcc atctcaaaat agatatatat ttttttcttt aattatttcc 428160 ttttctgtgt cctgaattcc tggaattttt ggaaaaaaat aggttgaata ttcatgtcca 428220 gttcataggt ttttaaattg ttctatcagg ggtttttttt ctctaaattt ttgtgaaaca 428280 tttatagttt gtatttgtat tttaccccac taattcaatt ttatgcatta ttctactgtt 428340 ttcagtcctt aattcattta tcatgttttt tcatatctat ccagtttatt cacatcctag 428400 cctatcccct cattttagca gattgttcta gtttcacata caaaattcct ttttggttta 428460 tgttgtgata attaattaga tgttttctaa aacactaatt tttactgttt gctaaacaat 428520 cttacttttg cccttcagta ccggcaatcc tgagcaaaag aaggcttgct ttgattgcca 428580 gtaaaaccca tgttcttgtg gccataatct tcacctcaca taacctaaac accctccttg 428640 gaatattaca aaattctccc gttcccagct gcagaactat atgaattgga tttacagata 428700 tcatagtttt tttcagcatc cacatcttta acttgaattt caattaaaac ttattggttg 428760 gtcaaaactt aaactcttag aagatttttt gctcagatac catgtcaaag tttagaggac 428820 gttcactgaa tcctttcctc tggccagcct tactttcctg tcttcccacc cagacagttt 428880 tccagaatct gagcattgaa atctcctgcc aaacacaatg gataacactg aatctcaatg 428940 ctttcaatgg atggcattga aatctcctgc cgaacacaac tgatactctg gcttcatgtt 429000 catgaaggtt ctttacaccc ctctaatccc ctatcgtact tcaatggtta cttccaagga 429060 agttctccaa tctgcctttt gttgaggaac ttttgcatag aagaaagggc aggtgtatcc 429120 acgcactagg tctaggtttg aggctgcctt aaagttactg agggcaaggg gcttcataat 429180 ttggagcctc accttccccg tttatacatg aggatcatga tagtggacag gcatttttct 429240 tagaaataaa tgagataatt tgtataaaca actttttttt tgtattttgt tattgtgatc 429300 ctttcttcat gtctattatg tcaagtgatg tacttatgtg aaagggattt tttaattttt 429360 cttgtgatta atattaacta agcacaacga ttataatttg ctaagttaaa ctgaattaaa 429420 ttgctttata tatctagaac cagaccggaa atatctgggt ggttattata gctaaattcc 429480 atactatagc aataagataa aatatgagtt atttactgtc taatatggac atatacatgg 429540 ctctgtatat ctatttttct tcatcaaata tcaaatgcaa tattacacat tagacacaac 429600 aattaacttg tgttcatgtt tctgaaattg attctaatgt attttctatt gtactcagaa 429660 atttaccatc aatttgcaag atctttataa tgattattta aagattacct tatttcttca 429720 cctttattgt cttgaaaaat ggtttctgct caaaaagaat taaatctgta aatgacgagt 429780 taatgggtgc agcacaccaa catggcacat gtatacatat gtaacaaacc tgcacattgt 429840 gcacatgtac cctaaaactt taagtataat aataataaaa ttaaatctgt atgaaatatt 429900 atatattggc aataaaaaat gaaaataaat gagataaaaa tagatgttca cgcaacctta 429960 acaactttac aatgctatta aaggaaaatt ttaggaaatt tcctattcag ttgggagttg 430020 tcatattgga aatgcaaata tggacgtcag agttacagat atagtcagat gcctcaacca 430080 aatcagacca atgtcacctt ttcagatgac aaaatttgaa ggagcattgc acgttccaga 430140 gtcccttgat tttcacctgt aatgatagct agttacatga gatgttcttg aattttgaaa 430200 ttataaagca tttttggggg gcatgaaatg ttcatgaaag aatgagattt taaattttat 430260 ttacatttct gtttttatct ttctaaaaaa atcctaaatt aattctgaaa tcatcttgct 430320 ctataatcca accactagag agtagtataa tacctctcct agacatatca ttcatgaaat 430380 tttattaaag tttttattat aggatcctta ttttctttta gtttaataat tctatcaact 430440 caattgaagt ttatatcaat ccctacaatt tttttttgca aatagctcac ttttttcccc 430500 aaattgctga aactacaaac ctgtcatttt tcattttgct cttgctttgt cttgaaatac 430560 agtgactatt cttgtctcca aactctttgt ctgcttattt tggcaaaatg acaacattta 430620 cacaagagat ggcaagagga atgtccattt tctttattag ataacttcaa caagcatcca 430680 ttaagcacca aaaacttacc aggcacagag tgcaaccaag ggtatttcta caaataatta 430740 cgaggctttt ccttccttta ttgataaaac acgcagacag atgaagacat aatctgtgtg 430800 tgagcacagt gggtcaagcg atcagtacaa ataagggtaa cggagttcag aaaggggaga 430860 aaccaatgca ggatgggctg tcagaaaaat gccacaaaga aatagaggag tgggcaggag 430920 cagagccttg aaggacaggt atgaagcaga gcgttaaatc aaatgtgtcc aatccagaaa 430980 aaggggatcc cctcatgtcc agccaaggca ggacttttca catcatgtcc aagtgtgcag 431040 gtcattttat tgaaaaaaat atatttgcac agaaaaactg atgaagtcta gattgcaaat 431100 aacctctttt gcctattttg gaagtttgaa gtaatcctgt gtgcctgtag ttcccaacct 431160 ttttttctgc ctaaaaatag aaaatctgag ctataaaacc tatgtgtcat taataaaaat 431220 ggataatgat gacagcgatg catgacatga tggtgccgtc ctgagagttg ggggaaggtg 431280 tgtataggga ttgcggcagg ggttgggaga gtttagagag gggaagcagt gtataaggat 431340 gagaagaccc tcgaagaggg tcccaccggc cccctgggga gcctgtgcaa atggtgcctc 431400 acagcaatta ccttgccagg gtgtgagatc tcccttagag ggatagaggc atttgtgcag 431460 ttctgcagat cagatttctc cagggccagg gcaacttccc tgtccaggcc taggccagtt 431520 cttttgtcct ttcaggattc tagatttctc ttccagtatt atcacaatgt ctcctaagca 431580 actgtgctcc ttgaaaacat ttggtctcac tcctcagcat cttgcacagt gaccatccag 431640 acctgggtca ttcattagtt tgtctacctc atattcattt ctctttgaaa tacatctata 431700 actcagtata ttagctctgt ttgttgtttg aacagtctaa cagtggtgcc accaactttt 431760 ggcacgctct gttaaagaga ctgtagatga cagtgccctt ttatattccg ccatgttgca 431820 ctgctatttt gtcctagaaa ttgagccagt taaattccat ctgtcttttc tttttttata 431880 actatataaa atcatgtatc ctacatttaa atataaatac agagctttgt tagaaaaaat 431940 caggctcgtt tgatgataat ctttaatttg atatcaagaa atacattcta ttgagtacct 432000 aacatgtgaa aaacgtccaa atcaaattcc aggtcttttt ttctcaggct ttttcttcct 432060 ttgtttccat ggaatcacac cttctttctg tagctttgat cctggaaaat gttgtaggca 432120 tatattataa atcctgctat atgtaacttt ggatatattt tattgagggt aagaaaattg 432180 tctcttggtt acttgtgaat atctatatgc tgaataaagc tgagatgaat aaatagctct 432240 tccttccttt gtcccatgtc ttgataaatt atctttttag cttttagacc tgatgactta 432300 ccttgtgctt tatcagaaca ctttgttgcc ttaggcaggt tcatgtcggc aggtaatgac 432360 tcactcgaga tattctctgc actttgataa taataatctg tgatttttga gacataccta 432420 tatagctaac tggatcaatg tatttcacac tgcaggttgc actcattgtt aggatctgaa 432480 atacatttaa tattgtaagg ccaacattaa agaaaaagaa agagaaaaat agggactaag 432540 caatatcaaa atgtacctca tggaaaaagt gtaaattatt cattaatatt ttgcattccc 432600 acaagtaata gttgaaaagt ttagttgtct cagttcttca cagtacgttt taattttagc 432660 tattctagga ggtatgcgtt ggtatctcat tgtggtttta ctttacattt ccctgaaaat 432720 gatattaaac atttaaaata tgctaattga ctgttcatat atctcctttc actaagtatc 432780 tgttcaaata ttttgcacat tgtaaatggc aaagaagact tttgttttct tatagtcgag 432840 ttctaagaac tcttatatgt gctagatacc ggtcccttat catatatatg ttttgtaaat 432900 attttctctt aatctgcagt tggacttttt attttcttaa acgtattttt ggaagagcaa 432960 tggttttcag ctgtgatgta acttgtttta taaatatttt ttcttttata gctcaaatta 433020 tttttgtccc atataaaaca tctttgctta gcctaaggtc acttccgttt tcttaaatgt 433080 tttcttccag aaatattaca gtttcagctc ttacatttag gtctatgagc tacttcaagt 433140 taagttctgt atatggtttg aagcaataat tgaggtccat tttggccata cagatttctt 433200 agtttttttt cccctatgta tgttcacata ttccagcact actttttgaa ttttttcttt 433260 ctccattgaa ttacctgtgc acatttgttg aaaaccaatt aactctatct gtgtgggtct 433320 gttttcagaa tctaatcagc tccttaggtc cctatgttta tctttgtgtg aataatatac 433380 tgtcttgatt aggtaactct ataatgagtc ttaaaaccaa gtagtctaaa tcctttcact 433440 ttgttcttat tcaaagttgt ttcagtcatc ctgtatcttt ggaatttcct tgcagacttt 433500 ataattagtt tgtcaatatc ctgctgggat gatgattggg attgcattga atcaagagaa 433560 ataggagaaa ttggcaaaaa caaaggggct acaggcccca tgtaagtccc aaatccagta 433620 gggcagtcaa atcttaaagc tccaaaatga tctcctttga ctccatgtct tgcatctggg 433680 tcatgctgat gcaagaggtg ggttcccatg gtctgggcag ctctgcctct gtggctttgc 433740 agggtatagc ctccctcctg gctccattca tgggctggtg ttgagtgtct gcagcttttc 433800 cagatgcatg atgcaagttg tcagtggatc tacctttctg gggtctggag gacagtggcc 433860 cccttctttt ggctctacta ggtggtgccc cagtaggtac tctgtgtggg gactctgacc 433920 ccacatttcc cttctgcact gccgtagcag aggttctcca tgagggccct gcccctgcag 433980 caaacttctg cctgggcatc caggcatttc catacatgtt ttaaaatcta ggtggaggtt 434040 cccaaatctc aattcttgac ttctgtgcac tcgcagggtc aacaccatgt ggaagctgcc 434100 aagacttgag gcttgtaccc tctgaagcca cagcctgagc tctatgttgg tccctttcag 434160 ccacagctgg agcagctgag atgcagggcc ccaaggccct aggctgcaca cagagacctt 434220 gggcttggcc catgaaacca ctttttcctt caggtctgtg atgggagggg ctacagaggt 434280 ctctgacatg ccctggagac attttcccca ttgtcttggg gattaacatt tggctcctag 434340 ttacttattc aaatttctgc agcaaactgg atttttcctc agaatatatt ttcttttcca 434400 tcgcatggtg atgttacaaa ttttcccaac cttaatgctc tgttcccctt ttaaaactga 434460 atgcctttaa cagcacccta gtcacatctt gaatgctttg ctgcttagaa attccttcca 434520 ccagataccc taaatcatat ctgtcaagtt caaagttcca cagatctcta gggcaggggc 434580 aaaatgccat cagtctcttt gttaaaacat aacaagagtc acctttgctc cagttcccaa 434640 caagttcctc atctccatct gagaccacct cagcctgggt ttcattgtcc atataattat 434700 cagcattttt gttaaagcca ttcaactagg ctctagggag ttccaaactt tcccatattt 434760 tcctgtcttc ttctgagccc tccaaactgt tcccagcctc ttcttgttac ccagttgcaa 434820 agtcacttcc acattttcag gtatcttttc atcagcaccc cactggactg taccaattta 434880 cggtattcgt ccattttcat gccgctgata aagacatacc caagactggg caatttacaa 434940 aagcaagagg tttaactgga cctacagttc cacatggctg ggggagcctc aaaatcatgg 435000 cagaggcaag gaagagcaag tcacatctta gatggatggc agcaggcaaa gagagaatga 435060 atgccaaatg aaacgggttt ccccttatca aaccatcaga tcttgtgaga cttattcact 435120 accacaagaa caggaaagcg aaagacccaa ctccataacc caaacaactc ccaccaggtc 435180 cttcccacaa cacatgggaa ttatgggagc tacaagatga gatttgggtg gggacacaga 435240 gccaaaccat attagtgagt attggtagtt tgtggtttta tgagaaacta gtctaaggtg 435300 tttaatttgt atgtgtagaa ttgcccatat tattctctta ttattctaat atctggaaga 435360 tcttcagtgg catctcgtat ttcattactt atattggtaa tgtgtgtctt ctctcatttt 435420 cacttcttca gtctttctgt ttatcacttt gatatctatt tcacatcaat ggttttagct 435480 attataactt atgttgagta gtgtttatgt gagatttttt gtttgcctta ttttttatat 435540 ctttttgctt taacctttct atgacttaac ttaaagtatg tttcttttac acagcatatg 435600 attaggtctt gcattttata caatctgata atatttgctt tttagttgaa atacttgcag 435660 tatcaaaatt cagtgtgatt attgacaatg ttgggtttca gtcttgctat ttgttttctg 435720 cttatcctat ctatcctttg ttctatcttt ccccctttct tgccttcttt tggattaagt 435780 ccatatttca ttgtattaat tgtataaaac attattttgt ctccattcgt ggcttattct 435840 gcccctcttt tgttgttatt gtttgcttgt ttgttttccc ctacaattca gtgtgtgtgt 435900 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtat ataattactg tctatcttca 435960 agtaatattg agtctggtca catatattgt tgaatcttat tacagtgtat ttccaatact 436020 cccctgctag acttgctact atttttgtgt gtattttatt tctacatatg atgtaaactt 436080 cacaaaatat ggttaattat cttttaaatg gttaattatc ttttaaagat attttaaaac 436140 tgataataaa aggtgttaca tttaaccaca tattttctga ctctcatgct cctcacttgt 436200 ttacatcggt tgaatttttt ctgatgttct tttctttctg ccagaaaggc tcctgtgagc 436260 agtttagtgc aggtctgtgg gcaatgactt ctttctactt tggttagttt tagcaagact 436320 caactttact tacttttttg aatttttttt ttttgtactg tatagagaat tctatatcaa 436380 cagtttttct ttgaaaactt tacaagtgtc accccattgt ctctggtttg catggcaaaa 436440 tcttgtcttt cttgtcttca tttgttcgta atttaaccct ggccccttta gatatttttt 436500 tcttcatgac tggctttcag cagtttgata atgatgcatc tcggtgttgt tttcttcata 436560 tgtccttggc ttaatattaa cggtacttat tgcatctgtg gctttatagt ttcatcaact 436620 ttggaactat ttatttcaat actcccttca aatatttttt ctgttctatc tcttctttcc 436680 tctgatagga gtcctaactc tgcctcccct aagtctctaa ttgcacatat tctatactgc 436740 ttgatattac acttcaagtc attgatgctt tgttcatttt tatctggttc tttttctatc 436800 cgtatttcat tttgtgtagt ttctattgtt gtttatgagt tcacagatga tttcttctgc 436860 attgcccaac ttcctattaa tcccaaccaa tgataatttt tcatttcaga tattaaattt 436920 cttatcttct aaagtcttac ttgggtttaa tttttatatt ctatttccat ttatactatc 436980 ctttttctgc cttcttgaaa atggcacata tttatgatcc gtgttttaat ttccttgcct 437040 gttaatttta tcatctgttt catttcttta ttttttggac tgttaaaatg gatttatttt 437100 tctccatata tataattttg ctttatataa tatatacata tttctgcttt agacatgttt 437160 tgtaattgtt tagtggatgt cagccatttt gaattttatg ttttgggtgc tggatttttt 437220 agttttcttt caatattgtt ggacagttta ctgggatgca gttgagttac ttggcctcaa 437280 tatgattcca tcaagccttg ctttaagcct tgtttgcaca gttcttgttt gcatggttcc 437340 agtctagaac tgattggctc ccttactaag gtaatattaa tacaattctg tggtttctac 437400 ttgatttctc aaatattcag acatactttc actgacttgc agggatacaa actattccca 437460 cctctgtatg agctccagtg attcttgttc ttgccgtagc cttggctaat cttcccacat 437520 gcattatcag aataactcaa taaaagacag gggtgggccc tctgtaaaac tcaggatctg 437580 tccacctctc actaggattc ctctagtact ttttcctaca ttctagctct gtggcctctt 437640 cagcgttgaa actgtgctct caactcagag aagagaccat caggctggtt gggtcatctc 437700 tggaaaagca gagatttcac tttgttcgct ttccttattt caggcttccc tgcatgtttt 437760 ccaaatttat aaatcactat ttcatatatt ttgaccatga ctcaagttgc ataagataaa 437820 agggaaaata gggactttct taatcaaggc tgaatgtgga agtgattata gtgtaatgta 437880 acatttaaaa atacaaatta cattctaatg gaacttttta atgccatagc tctcaatact 437940 cagaagctaa aggtattgcc agtatttact gtacagtttt tatgactatg tatttgggag 438000 cagttttgaa aatacaccct taggtattta aattattctt taggcttaat ggttttcttt 438060 ctttgtaagc attaatattg aactataatt gttatccaaa taaatattta gtgatttctc 438120 agagaaaaag ataaccacac attacctaaa cacctggata ggtcagatga taatattcta 438180 gttccattca taacatacta aaaatggact atttggagat tgctacctat tagagaataa 438240 atgtctcatt tatcggaatc acactagcct acgaactcta gttatgtcat ttaaaattat 438300 gactggcatc atggggcaca cagtgactgc actgcacatg tgagtgaaca cgtcactcca 438360 gctgtgtgtc agacaggggt actgcatcat ccctcctgta ggaatgagtg ggctcgggga 438420 aggaaaatgg agggcacatc aacagacaaa aacaaagcct actgaatatc cataaatgat 438480 gtaactaaat cttaggatag aagaaaccta caagaaccaa tgccaactta cgactgatga 438540 atgtctgttg ctgtgtcaga aataaaagat attcaatttt caggttgtca atgctcctca 438600 ctaaatgtgt tccccaaact gaatgtgatg cccagatgat ctcgtagggc aatttccagc 438660 aaatgtctca taaccagcat gtcccttcac attgtttgtc aatagccttt caagccctta 438720 aagctcaaca tttccagaat gtatggtttc ccattctaat gataatctat tttaataagt 438780 taccttaaat tccagctttt cagtgtcctg tccccccacc ctatcacaga ccttccaact 438840 tagtaaccat tctttctttc tcatcatcca cgtcatcaat gaaaattgtc aatgctaacc 438900 ctgaattatt taggcttagt gtacttcatt ctttatttaa tatattcttt gttttcatgt 438960 tgggcaccga gatgacccag ggcttagata attctgtgcc tccttgtagc aacacaaacc 439020 tattttcagg caaagatggg taatatcttc tgttgttaaa acacagtgaa cacagttctg 439080 tagtgctgtg taaacccacc aggtagccag cgagccttat aaagagctaa gttcctttga 439140 tgggctcctt gaaagataag gaaccatcaa gatattcctc tggatctggt tcacacccag 439200 aagggttata accagttatt aagagatgca taacaaatca cccagaaagt tattactcaa 439260 gataaacatc attgtacagc ttatattaat aagtttttgg gacaggaagc agagcagggt 439320 tctggagggc agcttgtccc tgcttcacat gctgtcacct ggactgggtc tgaagaatca 439380 aaagtggcct cccacctgtc tagaacctca gctgagacag cccaaatgag tgggcttgca 439440 gacctctgga gcctcgctac tcttccacat gacccttgtc tttatatgga gtgtctcatc 439500 ctccagggtc tcccctccat gtgacctccc tctttatatt aggaagtttg gattccttct 439560 tatgtctgct gggttccacc tgagcaaaat tagaagcttg aaagacctcc aaagggtcac 439620 cttgaatctc ccaggacatt acctgcattg ctttctattg gtcaaagcaa gtcacaaagc 439680 catcccagat ttaaggggca ggaagagtcc ctacccttga atctgggagt taaggcaaag 439740 ttgtctcaca aatgggttgt tgacatggag aggactgatt tattggagac cttctctttt 439800 taaaatttag ttttagtgga cacataaaaa ttgtatatac ttatgttgca caacatgctg 439860 ttctgaaata tatatacaat gtggaaatgt acacaattta ttctaactga gctaaattag 439920 ataaagctaa ttaaaatata tattactgca gactcatttt ttgtggtgtg aacatttaaa 439980 acctatgctt ataatgattt tcaggtatac aatacattgc tattaactat agttgctatg 440040 ttgtacaata tatttcttga atttattcca cctgtttaac tgaaagttta tattctttag 440100 ctcgtatctc tccaatccct ccacctgtca gccccaggta accaccattc tactctctgc 440160 ttttatgagt tcaagttttt agattctacc tatgaggctg ggtgcggtgg ctcacatatg 440220 taatcccaga attctgggag gtcgaggcag gtggatcact cgaggtcagg agttccagac 440280 cagcctggcc aacacggtga aaccctgtct ctactaaaat ttaacaacaa caagaagaag 440340 aacaaaaaac acaaaaatta gcatgtatgg tggcacacac ctatagtctc atctacctgg 440400 gaggctgagg tgggagaatc acttgaacct gagaggtgga ggttgcagtg agccgagatt 440460 gtgccactgc actccagcct gggtgacata gccagaccct gtctcaaaaa caaacaaaca 440520 aacaaaaacg ttttacatat gagtgagatc atgtggtatt tgtctttccg tgcctggctt 440580 gtttcactta gcgtaatgtc cttcaggttt atccatgttg tttcaaatgg cacgatttca 440640 ttgctttttt aaggctgagt tgtatttcat ggtttataca tattttcttt attcattaat 440700 gctttggtgg acacaggttg attctgtatc ttggctattg tgaataatgc tgcagtgaat 440760 atgggagtgt agctgtctct tcaaatattg atatcatttc ctttggataa ataccaacta 440820 gtgggactgc tggatcatat ggtagttcta tttttagttt tttgaggagc ttccatacca 440880 ttttccatag tgactgtcct agcttatgtt ctccaccaac agttcatagg ggttcccttt 440940 tctctacatt ctcaccaact cttgttttct ttcatcttat tgaaaatagt cattataaca 441000 ggtatgaggt gatacgttat tgcggtttta aattgcactt ccctgatgat cagcaatgtt 441060 gagcatttta tcatataccc cttggccatt tatatatcat ctttctttgt tgttgttgag 441120 acagagtctc actctgttgc acaggctgga gtgcagtggt gcaatctcgg ctcgctgcaa 441180 ctgctccctc ccaggatcaa gcgattctca tgccttgccc tcttgagtaa ctgggattac 441240 aggtgcacgc caccacaccc agctaaattt tgtattttta gtagagacgg ggtttcgctg 441300 tgttagccag gctggtcttg aactcctgac ctcaagtgat ccacctgcct tggcctttca 441360 aaatgctggg attacaggca tgagccactg tgcccggcta tatatcatct tttataaaac 441420 aagtattcaa gtccagtccc cattttttaa ttagattatt tgctttcttg ttattgtatt 441480 gagtctctta tgtattttgg atattatcag atatatgatt tgcaaatatt tcctttcatt 441540 ttgtaggttg tctcttcatg ctgttggtta tttcctttgc tgtgcagaag ctttttagtt 441600 tgatatcatc catttcacta tgttcccttt attgcctgtg cttttcgggt caaatacaca 441660 aaaattattt gcccagacca atgccatgtg gcttttctac tggggaccac ttttagcata 441720 tatcactaat gcttaccccc aaaattgcac cagtggatat aatgctaggt cttgataaat 441780 tgctcaactc ctaagtgcat gcatagatat tatatacaca aggtctcaga gggataatat 441840 ggtaagatgg ctgctctgat cccagtttaa tgcatgaaag accctgttac attttcccag 441900 ggtctacctc tgctcagtgc tttcagaaca taagcatcac tcagtatgaa aattattatt 441960 tttactagac aatatacgcc actagattct cagttcctgg gggccatggg ctatgtccca 442020 ttcacctttg catctcccat acttcatggc ttctgttata cgggagccag ctgcccagtt 442080 gaaaaaccaa aatagctcaa cttgaataat acatattttg tactgaagca aattaaaagc 442140 cttgctgtaa ccacactaaa ttatttcata tgtctctgag atcctagaat ctattgccta 442200 ggtctgttac tgggtgtgcc tgctgacctc atgaatatca gtcattttag gaaagatgat 442260 ccatccattg aatcaaaatg gaaatgaatt tgaagcaaac agtgccagga gtgcaaactg 442320 aggagacttt cctagaggat gacagcacag tgagctccag tcaaggaggg accacgcctt 442380 cctccactca ctattctata tccaacccct ggcctggagc ctggtgtatg acaagcccta 442440 tgtgttaaat ggagtgttgg caatgataga actttccgga gaggatatct aaaagtggaa 442500 ttattccctg tgtttattta agtgcaattc aaagagcagg tttttcagag acacacagga 442560 ggagcctgga aaatctgtga cgtgttaagg gacttgtgct gtattaaaga aacaccaggt 442620 ttccaaggaa acccttttag ccttgtgctt aatgtttgct cttctgccct caagaggccc 442680 agtgaacaca caattgttta taactagtca agagactgga tcttaggaaa tcacttgcaa 442740 aattgtccaa aattcctcta aaatctttga tctaagagat ctccaaccgc ctcttggttc 442800 acagaatctg aaacagtatc ttaactgttt cactttgcta tttatgtaca tttccagaac 442860 attttgcaaa tgtaaagtgc ctcgtagcag cattttgttt gtaccataga tgaatccctt 442920 tgaagttaac ctttattgag gcaattgtta aatgcagtat catgaacttg tgttcacaga 442980 agacaggaaa agtgtaagct ataggtctga aataagagag aaataagaga gtcagcaagg 443040 gacacagcag tccatctcag ggctttctca tttatgttaa aaagggaatt aacatagata 443100 atctatgtca gtttcttggc acaatgctga acaggtagtt cagtaagttg tagccatgat 443160 ggtgatcatg atgatgatga atgatttgga aacagacatg cctgattttc atattatttt 443220 ctaagatatt ttcttcatca aatgttctga acacttaaaa cttaactgct gtatgcttgt 443280 cacaggcaca ttcaatactc aagctttatt aatgagcata atgtcctcat cagccattca 443340 agtctagggc cttctatcac attttaggct caactatctt cttttgtgat tttgtcattg 443400 gtagcctcat ggtgaaattt atggctctac agagagaagg gcatgtgtat tgtgtgtgtg 443460 tgtgtgtgtg tgtgtgtgtg tgtgcacatg catgcttgca tacatgtatg taagcatgtg 443520 tgttgatgac aatgattagc ctgccaaacc acccatgtaa gaaatcggct gtataaggca 443580 tagtttgtta aaccacaagt ctgattttaa ggtttccaaa gaaaattcca ctgggcattg 443640 tctttaattt attctttgta aaatagattt actctgtagt cccagctaca tgggatactg 443700 aggtgggagg atcacttgag cccaggaggc agaggttgca atgagctgag attgcatcac 443760 tgcactccag cctgggtgac agagtgagac cttgtctcaa aaaaaaaaaa aaagatttac 443820 taatcacctg gacattaaaa aattgttctt ttaaaatgta cattctccat taaagtatgc 443880 tagttcattg ataccttttc ctttttaata tttcaaggga tcactggaaa tatatagtga 443940 tgcttttaat aattatgtcc tttctaatca ttccacatca ttgagcgtgt taagcacaca 444000 tgatgtcagc tttggtgctt gatagaaatg atacaaggtt ggcatgttat tggaagtgcc 444060 tgctttcagt gtctagtgaa ggatattggg aaatagttaa atgagccaga atagggaatt 444120 actatgaatt atggggtggg ggggtataat cttgcttcca aattttctca attgtgttaa 444180 ttcatttttt cctgtacttg tctctcttaa gtaatacaaa gaaataattt attgatagct 444240 attgccttac tctgagtttt gatatgtcat taaaattaag ccttaaaact ttgtattttg 444300 aaaggtcaaa aaatggttag tataatgaga acctgacttc ctaaacctaa aattaaaatg 444360 tatctcagaa tcaattgaat ttttccttca agaaattgtt gttaaatctt cctctcaata 444420 aattaaaaaa aaaaaaacaa ataaaaaaga caatgtcaat tttgagttaa gtgccatttt 444480 ttttaatcct gtttatctac aaggagccac agtctgccta actttaggta aagaaaagca 444540 gtatcacttg gaaatatata gatagtttac tccccgtgga aaaaatcatt atttctccat 444600 ttagaaataa tttcacattt aagatctcta gaactttact ttttccctag gcagatactt 444660 gttctaatga tctgagaggt aaaaactctt agcttagctt cttcttagga atctaatacc 444720 atttgtctta aaaataatat attttagccg ggcgtggtgg ctcgagcctg taatcccacc 444780 actttgggag gctgagacgg gcagatcacg aggtcaggag actgagacca tcctggctaa 444840 cacagtgaaa ccccgtctct actaaaaata caaaaaaaaa ttagccgggc gtggtggcgg 444900 gcgcctgtag tctgtagtcc cagctactcg ggaggctgag gcaggagaat gacgtgaacc 444960 caggaggcgg agcttgcagt gagccgaggt ggcaccactg tactccagcc cgggcgacag 445020 agcgagactc tgtctcaaaa aaaaaaaaaa aaaaaaaaaa aaaaggaata agaataataa 445080 gaataaattt tacttgacca tttagaaatc ataaatgttc cctgtcaacc acacggggaa 445140 cttaaaaggg ggaaacattt gattattgtc cagtgttgct ctgctcagtt gggtgtaaaa 445200 tatagctagc aaggctgggc cgacttctgg agaaagagga aggagagctg gcaagacggg 445260 cccatggcag gtctccaggt cagcagcctc cagaggggaa catggggccc ctttggaagg 445320 ccctggcttg ggctgggctt tgtgctgttc tcttgaccct ggtgggaaca tggctgtaag 445380 aataccatcc ctgtctactc tccttatatc ctttgtaaca tatgattatc ccatctgcag 445440 cacattttaa atcacaatgc caaagtgcaa cagtcctcaa ggagtggtcc ctgcacgctt 445500 gatggtctcc aagacccttt agggatttgc aaggtcaaaa ctactttcaa gataatattg 445560 agatatcatt cactttcttt gttgttttga catctgcaat ggtggataaa attgctggtg 445620 tctcagcagg tgtcaaggct gcgggatcca attatacttg ttttgtgtaa atagtgtact 445680 atattcttca ctgctacaca ctaacagaaa aaaaaatcca attttattga gaatatcctt 445740 tatgcagcca tataattatt agttttattt tatctcaacc cttgagtata tgacttttta 445800 atagcctctg tgaggaaaca ggaaatgtat tcccataaag tgtggttatt ttgaggaaaa 445860 gcatttgagt ggttgagctg caagctgaaa taatcctttt cttaatagaa ctttaaaaaa 445920 gttacttttc ctgttactgt tacttttact tagcggaaca agggacagaa aactatggta 445980 atttggacta cagatgacag ttattttctc aaagtatgaa ccaaggtgat cctgttactt 446040 caaggaaaat aaccaacagt atttgattca atggtaaaat ttttcaaaca aaaattcaaa 446100 ttgtggaaaa actgtatcca ccattatgta cttgacagcc tcccaatatt taaagaactt 446160 ttgtgatgag atcagtgatt atattaacaa atatgatttt ttagtgttat atattgaaac 446220 ctgtcaacat ttgaaagatc tgcataactc agtgaactat aaatgactaa tgcatgatgt 446280 tacaaaagtc atgcattagt aatagatcca tttaaagctc aagatagggc aatcaatttt 446340 aacataacag agtatgaaaa taccattcca actaaccttt aagaaattac cccagaaggc 446400 caggcacagc ggctcatgcc tgtaatccca aagctttggg aggccaaggc agaaggattg 446460 cttgaggcta ggagttcaaa accagcctaa gcaacatagc aagaccttgt ctctacaaca 446520 aaagttttta aattagctgg gtgctcatgc cactgccttc cagcctaggc aagaaaccca 446580 gaccctgtct aaaaagaaag aaagaaaaaa aacttacctc agtagaatat tcacaattac 446640 ttacaaagac tattaaaaca ctcctttatt ttccatctac atatctctgt aaagcctgaa 446700 tgcagatgca gatatgagaa ttgagcattc tattagggta gacgttaaaa agatttatga 446760 aaatataaac aatattactc ttctagctat ttttttgttt tggaaaatac aatgttttca 446820 ttaaaatatt tttaaataat gtaatggggt tactatttca tttttaaaat aaatacatat 446880 tttaaaatct tttaagattt ctaccacact aaatataaat agctacaaat cacataatga 446940 aacctcttta tggtctccaa taatttggaa aagtgtaaag gggccctgag acctgctgca 447000 cgggaggaag gtgctcccgg aacagggaga aaggttgagt ctggggaatg ctgaccatga 447060 cacctgcttc aaacacagat tccctgtggc tgtttttcct ctaggattct gttaaaaatc 447120 ctgttgaaga atccattcca catatgggta aaatttagaa atatgttccc tggaactggg 447180 aaatccaggg acaggagaaa aaagcagcaa cattgctttg ttactttgtt ttacttgcta 447240 catcagacaa aaaacaaaaa ggaatggata taattatttt acgtacctct taagggcagt 447300 gtgaggttta tgtgagtcaa cgtttataat gcacttaagg catacttgtc actactaagt 447360 ttatataaat tcttgttaaa taaaaatgaa tgaatgaatg aataagcagc ttctaacaga 447420 aaccgtggca gcattttttg ctgagcacat tgctaggcag taactaaatt aatatgatgc 447480 ttgacctcag agatttagga agttggtcca atctaggcac atgcagagaa gatacgttta 447540 gaattctgaa ttttgatgga tattatctca aatatctttc tgaaacacag cgaaatataa 447600 agacttttat aaaatcagat agcatgcaca caggaattga caatccaggc tctccagttt 447660 aagtaggtgg atttcctaaa gaactctaaa gatatttagg aactagaagt gactcagctt 447720 ccaatataga aacccttttc cacccatact ctcaaaatca atgtgaaata gctatttgta 447780 gatggaatct ttggactcct atgttttgtt ttgttttgtt ttgttttgtt ttgttttgtt 447840 ttgtgagaca gggtcttcct ctgtcaccca ggctgaagtg cagtggcaca gtcatagctc 447900 tctgcagcct tgacctccca gtttcaagca gtcttcctgc ctcagcctcc caagtagctg 447960 agaccacagg catgtgccat cacacccagc taagttttct atttttgtag agtcaaggtc 448020 tggctatgtt gctcaggctg gtctcaaact tgtaggctca agctacttgc ctgccttagc 448080 ctactaaaat gctgggatta catgtgtaag tgactgcacc tggtctggac cccaatttgg 448140 ctgaatcatt cattcctcaa gcaacaagta cttacatggg agatacaaag aaaacaatat 448200 tgcctcttct tagaaagaaa ctcctaggct gggtgcggtg gctgacacct gtaatcccag 448260 cattttggga ggcagaggtg ggcagatccc gtccctacta aaaatacaaa aattagctgg 448320 gtgtggtggc acacacctgt agtcccagct acttgggagg ttgaggcagt agaatcgctt 448380 gaacccagga ggtggaggtt gcagtgaact gagatcatgc cactgcactc cagcctggcg 448440 gcagagtgag actccatctc aaaaaaaaaa aaaaaagaaa gaaaaaagaa aggaaagaaa 448500 cttctaattt cacagtggag atttcagtgt gtatgcataa ttccaaagtt agcggagcag 448560 acagagcaag ggtgttggga ctgtagagcc ctagaggcta attttaagtc cagctccaat 448620 cattttgtat ctgtgtgaca gcaagcaagt tatttattat tttaaacatg ggatagggaa 448680 ttgggggtat tttgacattt taggaagagg aaatgaatgg tgtgagtgag cacaggggag 448740 aaaactgcaa ggtctgttgg gaaccatttg gagtcaactg caaaagggat ccgggctgta 448800 ggttaggatc tgggacaagg tcatgtttaa ggggaccttg aacttcagga tgctcagaat 448860 aactgaggaa ccattaacat tgggtcactt cttaaaatgt ctgaatcaaa gtgacatgtc 448920 ccctaagagt gtataagtgc ccagagcatg aagattccgt agtttgtaga caggcccagg 448980 accagggaat ttaggtaagt tttttcagca atagccagca gaatccaaac atccttaatg 449040 aggtactgtg tgcagcacag cctcctaaac tacaagctta ctctcaaaag tgtaagttga 449100 caaggagtaa tgctccgggt gctcttagag tagtggtaga actagtggca gtagtggtgg 449160 tggtggtaat tgttgcagta gtaatggtgg tggtaataat ggtatagcaa taatagtaaa 449220 agtagtggca gtagaagtac tggtagtggt agtagtggtg gtggtagtat tagtggtagt 449280 agtgatgata gtaggggtgg tagcagtatt ggtaatagta gtagcatagt agtggtggta 449340 gtattagtga tagtagcagt agtggtaata gtggtagtag tagtaccgcc aatagtaata 449400 gtggtagcag cagtggtaac agtagtattg gtagtgttgc caaaacacta ggggttcagt 449460 ctaggtccta ctgctcgcca catgaatgcc aatcactgag tgttttaggc tgttcttgaa 449520 ttgctataaa gaaatacctg agactgggta atttagaaag aaaagaggtt taattggctc 449580 acagttctgt aggctgtacg ggaagcatgg cattgggcat ctgctcagct tctgggaggc 449640 ctcaggaagc ttctcatcat ggtggaaggc aaagggggaa caggcatgtc acacggtgaa 449700 agcaggagca agggagagag tgagagggag ttgccacaca cttttaaatg acaagatctc 449760 gtgtgaactc agagcaagag cacactcgtc accaaggaga tggccgaagc ccttcatgag 449820 ggagtgaccc tcatgatcca atcacctccc accaggcccc acctccaaca cgggatcaca 449880 tctcaacatg agatttggca gggacacaga ttcaaactat atcactgaga caatgattat 449940 tgccagtgaa gaagactatt ctggtgctgc agccaaggag atagaagatc agtctcaaat 450000 ccatctctca gattgattaa aattggggtt tttataggat gaaagcaatg taaccatgtg 450060 tgggaaaaca ggaattaggg aagggtaagg aaaaggagtt tgtcaatagg aagcaggtgg 450120 tcagttaggc aatcatgata ggtgagggtc tggtacctca ctgtctagat gtggtgatct 450180 gggaagtttc agttctttga tgttatctgg gaggccctca tggttagttt cctaagaaaa 450240 ggacttagat aagacaaatg taattttgtc aagttgtaag actgggaggg tcaatttcta 450300 tgtttattca aaagaaacta taaacattaa ttctatagga cagttgggcc agcatcagtt 450360 gtagtagctg tggtagatgg tggtagtggt agtagttgtg gtaggagtgg tggtagtagt 450420 agtagtagta gtagcagcag tggcagtagt aggggtaata acggtagtag tagtggtagc 450480 agtgttttag gggcctgcat tctccagtat tttcctcaca gaccagtggc cacaaccatt 450540 tccagttaag tgttccgttc ctggtgggca cccagctcag gaacactgca cgtgtgtact 450600 gtgagttgcc ccccatctga aatattcttc acctgctcac cctccattac tgagctgaaa 450660 cttccacaac aaaccaacag cctccttgtg ttgggaaacc gttcccatta cagtagatat 450720 taacgagccc taaatccaat ctaactgaat ttggctaatt cctaaagtta ggattttctc 450780 agaagttggc gtgatggtga agaatccctt ttctctggta cccgttatgg ttgacaatca 450840 gtgaagtttt cttgtgcaat tgcatggcat ttaaacatta ttttagcata tttttgtgaa 450900 ctaaatatac tattttggaa tttgaattta tcttttggtg agacatagta gcaaggaaga 450960 ggaagtaaac aaaatctctc tagtgaatta aaatataaaa tggtaaatgt catctcgatt 451020 taggaaccct gtcggcggtt cagaagcaaa atgagctgcc ctgagttgga gcctccatgg 451080 gacccgcttc cgtaggcaca ggcataaagt cagctttctg ttgctgaagg cttggaagag 451140 gctgcaggag aacactgtaa tcagatttga cattccgaac tgatggctga tgggctgtga 451200 gggccgtggc agggagtgat ttcaggggct ttaataaggc ttggcaaata aatgatcagg 451260 tcacactgtc actgtgtgaa tgccaatgtc tttctcccca atccattccc tgagaggact 451320 ccagggccaa atagaaaata aatttaaaat gaactgtgaa cactaaaaaa tctttaatag 451380 actttgtcca tggaaagtga ttctttttta taaaattgct ttaatgccca ttttctttgt 451440 gttcatgaat ataaagagaa aacaaaacca atagcaaggt ctcagtattt ctgatttttt 451500 tttaagtttt gtgatttaag aaaaaaaaag aaatcaaaga tacattcctt gcgaaggcaa 451560 ctatggaatc tacacccaaa tctccaaatt atattcataa gtcaattgta actaatttta 451620 gtattcctaa aagaatgaat ttacaaattg ctctcaaccc ttttagccta aaatatagga 451680 aaatgttaca gtctccaggt aggaaaaaaa acatgcgtca ttttacagct ggataccaaa 451740 gagactcaaa tttttgatct aaaagaaaaa aaaaaataca gaaggaaagt aaaaatagac 451800 ctgacctttg aaggcagaaa tttcttgtct ttaaatttga ctttcatttt ctttcattaa 451860 aataaaaata aaataaaata aagaatgccc cctaatagtc tcttctcaag ttaaaaatac 451920 tgcaccacat caaattattt ttggaaccag ccaagagagg aaagggagga agaagttaaa 451980 atacaatgct atcatttctt attgaagtta gaattttcat aacaatcttg ccaatgtttt 452040 tcgtcaatta cactgactga acacagtata tttgtatcaa acgacattgt ttgaccactc 452100 aaattaacca tgtaaaaatt acctaattct acctttactt ccttataaat tttccttaga 452160 gttcccttgg gaaatattta acatacagta aagatcctgg gattaaagtt ttaaacccct 452220 ctgccatcta agactgtctg tatttctatc ctaatctctc ttagtactcc ccaattacac 452280 acaaaggatc caagtctgaa ctggtatgcc ttcggttcta cagttctcag tgttgaaaat 452340 ctccctctcc cctgtcttcc aggtgatatt catccattat ccaaaacctc agcccaagat 452400 caaggctccc tctagggaaa agatagcttg gccctgctag gaagaatttt ctcactcttc 452460 tgtaaatact tctgtgcagg gtttgtgtgg ctcaatattg catttccact tctttctggt 452520 ttacctgcct tggttgaaga ctcagggaag caaaaagctg cattcccaga catagctgcc 452580 agggctctgg aagcggttaa aacgcagtca gatgcattgt gtatgtatgg agacttgaga 452640 gactctgaca gcctgttgag tgcaggttca tattctatta tttttcatcc tgactgtata 452700 aaagccatct ggtctgatgt ggaagaaaga atgtggcatt gggagtcagg caagcctaga 452760 ttgtatgacc ttggtcctca acctatgcaa tcttgctgaa actcagacct ctcattcaac 452820 taataaaaag ggttagggga attaaatgaa gtaatatgaa aaatgcctgg actgtagtaa 452880 gcaataaaga tcattgttct tatctttatc tcgcctcatc ttcatattct aggtgaagta 452940 gataagtgtg aattcactgc tgtatttaga cccccacaag attgtcattg cattaaacca 453000 cccaacaact gccttgacta ttccatgaat ttatcagttt gatgtctttc tttaagaaaa 453060 agtatagatt tgaccacaga aactttcctt gagagaactg tattaaagaa ataattagaa 453120 atgcagaaaa atatctattt ggaaacttat tttaattata atggtgaaat attagaaaca 453180 ctcaagaaca gataggctaa tccaattatt atatacccat ccaatggatt attacacagt 453240 attaaaatga tgtattaaag cattcaaatg acaggtagcc actcataatt tagcaacatt 453300 catacaatat tcattgagca catgaatctc ataaaaggat caaataaaat aagctgaatg 453360 gaaagctatt taaataacag tttaatctca attatctaaa tactatatat atgtagaaaa 453420 aagcatagac ggatatatgc aaacatgtta ataatggtca gctctggtgt tcagctgttc 453480 atccttggta atggaattat gtgggattta tattttattc tttctagttt ttatttttca 453540 gatttttcac actgtgccta tacttgtagt cagaaaaaaa tgtaagttaa agttttataa 453600 aatgataata tggatttcct attaccttga ttttaaaaaa atatgcctat aaaaacatat 453660 acatttagta aagtggcttt ctagaatttt cgttgtattt tctcctccaa agcacaagct 453720 cacaaaaggg ctgggaacat gtcttttcat gtttaaatct taatgaagac tcatccatgt 453780 attccctgtt cgtggagctg ttatggattg agtgctgctc cgcatcagag gtcatgcacg 453840 tggatctgga gattcctgga tgatgaaggg gaaggtgcca gagcctttgg gtatggcttt 453900 gaagtgggag agactgagaa atcattacct ttctttggca gtataccttt aagtctgcac 453960 tctttagatt tgagggcatt ctaaatcttt catccaagaa gactttgtgg tctcaatttg 454020 gagccgatat tagggaacca gcctttggag ctgcgtgcat taaatatggg cttacacttg 454080 atgtcaagga agcaaaattt gcctgatatc taacatgcac taataattct gtacatgtgt 454140 atcagctcat tgatcttttt agtacttgat ttgggggttg aattgtaaat tttattatat 454200 cttttgaatg tgttaaaatt tttttcatga ttaacagttg accttgtggc ttcctaagga 454260 gctctggcca agctgtgtca tgctttgaaa aatttcactg agttgtggac attgcttctg 454320 aggttatatt cactgtacta ctgctctttg gtcctttatg ggaagcatct cttcaatagc 454380 atcttgcaga gcttggcagg acctggggga aatgctcgtg tttgggagta gacccagagg 454440 cttcaccgtt ctgtacgtgg tggcttcttt cccttctgcg tctgagatac ataacacatt 454500 ccccatcctg gaattccaat tccagtgtta caagaacttg tgttctaccc ttctttctga 454560 cctcgaagga tacttacaat aaattcatgt gattattact ttctacgtcg tgttggttag 454620 tttcttagga aatcgttgaa aatatatgct ttacaggagt accattttct aatccactct 454680 catcctataa ctatttaaaa aatacatatc attttaggaa gagtgtggcc tatagatgaa 454740 cctctgatct gactatttga ggcttgtttt attgctctta gatttttcca aatatttatc 454800 aaacactgtt tatctttaac ccacactaga ataatacatg attattattc ttaatacctg 454860 tacataaata tcacttatag gcattaattt ttatagtact aataggtttg catgttcagg 454920 aagtactgag gattaaaata aaggaattcc tctcatttac ccaatatttg aatatgagat 454980 ttaagatgtg tgttggatgc cagacgagga tatgtagaat aaccatggag ataatgaagg 455040 aaataagaaa tgacttttga aaagactggt caaggcaact accttatgaa gactcagcct 455100 caggtgggta tttcaccggc gtggttccca cagcccgaac tccatgctct ttttcacatc 455160 tgcttccccc ttggagaggt gctttctctc tgggaagaaa gaaggggcta gccaaacttc 455220 ctggcgtgtg agatgaccca gagtcacatt ctaatgccta gtctgtgcaa attgtgtcaa 455280 cataccatac tcaaaatgag atttttgtag ttagcaatct tctaattttt gcaacgagaa 455340 atttccgata acagcaatgt ggtaatacac ttctctaaat atttgcagtg agcaagtatg 455400 tattgagtga acatacctga tgctatgtgg gacactgtag gagaaatcat catgcaccag 455460 tggggagaca tcctgtcact gacactgctc aagcttacgc taacctgtag aaaaactcca 455520 cagtatgaac aaccctggag agaaggataa atcatagtat gaaactgata aaattttaaa 455580 aagtcccctt ccaaagaaag aaacattgaa atgctctatg gttgtattaa attactttca 455640 agcacattgt atcatttgat caaactaagt tgatggttct ctaatcttct caatctgcat 455700 tctttgcacg taatttacat taactatagc actcttattt caaacagcag gtgggtagac 455760 tgtgtaaaat ttagcctccc tccagatttc tatatgtttg tgtttatgca ctcagcgatt 455820 tttaagcgta aaattggctt cttatttaaa gccaaagtga gtgaatagaa tactcattgc 455880 tgctcattct aacagccatg agtccagccc ctggtaaggc aatagctctc acctgtcttt 455940 gtgaatatta tttatattgc agcatttgct ggtatggttg gaccttcagg gattgtttaa 456000 ggagcacaat gatttcatgc ggtctgcatc atccaatatg aaatgttata taccttgaaa 456060 tatttttcca tagtgagaag gtctccctcc actccctaca cttgcaaaga accatagata 456120 cagttttctt tcttttattt taagcttgtt gctacctgag gtaggcaagg aatgagctgc 456180 tttgagatgt tataatagat tcaattgtgt cccctcaaat gatattgaag ctctaatgcg 456240 ccagtggctc agaatgtgac cttatttgga aatagggtca ttgaagatat aagtagttaa 456300 gatgaagttg tattggagta ggatgggccc ttaatccaac atgactggtg tttttgtaag 456360 aagagggaaa acttaaacac agagagaaca tggccatgtg aagatagagg tggagattgg 456420 aattacgctg ccataatcca gggtcattga ggcctaccag aagctgggag agagaaggga 456480 agatcttccc ttgaggcatt ggagtaggta cggacctgcc aataatactg ctggcctcca 456540 gaaatggaaa agaataccct gctatcattt aaaccacccg gtttgcagta ctttgttgca 456600 gcagccctgg gaaaataatg tggatgccac atcagaaggt gaagccaaga gcacagcacg 456660 gaatagggtg catcagcaat cagctaaccc aaggctatcc accttctctc catgaattat 456720 tcaggtctta tttttgtacc tgtcagtttt taaagggaga ttgtcatctc ttgattggct 456780 attacggatc catctaaaat ggttgctgtc taacagctga ctgatagact ccacactttt 456840 tacccctgtg cagtgaagaa gagtcaaaag aacaaaaatg tagtttttga ttgaatacta 456900 agatcagact catccacctg ctgagcaggt ctgaatacca ctgcacatgc aactgggcaa 456960 gcatagtcaa aggaggcttg attaagcaaa acgaagctga gacagctcca gcctctccct 457020 tgccccaccc tgtccatgcg tgcagctccc cctccaggag atttgaaagg gacagggtgg 457080 ggtggtgggg gaatggatag acacaggatg agcaggtgac caaggaggct tattctcaat 457140 gatgcctgat gagaagaaac acccagactt gtagctctga ccacacaata cgtcctctta 457200 ggatacattc tttctcattt attccccgtg tcctcacgtc cacacctgtt ctctcacttt 457260 tgcatccttc ccaaatctgt gttcttaagt tttctcttcc ttgatgcatg aacacgtggc 457320 atggccattg ggtaggaagc aatgcaggca aacaagtcgg ccagtgtaca tgaagatttc 457380 tcgagagtac ttgtccattc tgcgatggta acaggctata tcttctttca aagacaagag 457440 tttagggtgt ggtttatcac tcttttcatt aacctgagtc agataaatcc agattctgat 457500 gtactttatg ttttagatgg taagctcttt gtcaacttgg ttcatatggt taaaatgatt 457560 tggagaattt aacaaataat ttaatcaata tacctggaca gtattaatga taaaaatcct 457620 attatggtaa ttcagcatag attttctata atctattgtg gtactggcca aatacagtgg 457680 atatctttgg aatgtgccag aaagaagtgg tgcccactaa tcagatgtct tttttagaac 457740 attagctgtt ttttaacggt cctctttttt gttatttctc ttcataaaat attggctatt 457800 taaaagaata ttctctaatt aaaatttaat gtcaggaaat gaaagaaaga tggtttcaat 457860 gctagacatt tataatgact tttgatttcc ttgctcaaat gacaagtgaa gttttctcag 457920 catgacatga gaataattta tcagaagata taaaaatgag caaaatgtac attggagaaa 457980 acccttttgt actctcaaga agagagcaaa ttatcttaaa acacggggga tttctattca 458040 tcttttatgc aggaatatcc tacttttatt aaatacatgt tgaattacat tgagggaaag 458100 agtaaactta ccatattgta tcccacccat ttctaaatgg cacagggtag ttacactgta 458160 cactacattt actgtaagaa ttgctaagaa aagccaacat gaaatgagca tgttctacct 458220 ggaatttata aacaattact aagtgggaaa atgtggggag aaaatacagg gaatgaaatt 458280 aaaaagcaag atttgcttac ccagagtggt gaatttatac caccctactc caatagggta 458340 tgtgcatttg aatggattgt aataggtttt agtaggattg aacacacttt ccagaatgtg 458400 aagtttgcag tgcttagagt tgtatcaaat attttcaaag aacacagctg gtttatcagt 458460 ggaggagggg gggtttaaaa tggccttaac tcccgtgatt ttcctatgaa gattaaatag 458520 agtaatgacc atgacagcct tatggaaact gtaaagagca aggtctggtt tctcaaacag 458580 taaagagatg cctgccaggt taagatgtgg gtgaaatgga atttgtggaa aagtgtcaaa 458640 agcactaaag agattgcttt tcttcaccca caaatacagc acgctgacct acctcatacc 458700 gagaaacaca ggacttcatg ataccatctg ctgtgatctc cctcccatct gaaatgcaat 458760 tgtcttccag tgttctagag gcatctaact ttttatatca atcatatttg ccattattat 458820 cactttatac agtcattatt tgtttagggt tactcacgca tacctcgttc tttctccacc 458880 cttctttttg catctcatta ttgagtacaa tttcttttct ggaagcacat cctttagttc 458940 caggcgcaag cctgctattg gcaaactgtc ggttcttatc aatactggga aatttccaaa 459000 ttgttttccc aaatattgct tttctgccat ttttttctac cctctccttg aactgtggat 459060 ttcctctatc tctccttcaa gtctcttaac ctttctttca tatgtatctt tctttcttcc 459120 atatgtttct ttttctctct aggaaatatt ctgagtaatt tctgtagatt tattttcttg 459180 ttcactaatt tttcccaact gtgtctaata taaatattta tgtcaagggt tatgtgtttt 459240 atttctgccc attctgcaaa tattttattg tttatctaat atttgtatct tttatgatat 459300 actcttattc acttatccta tttttaattc aattctatag ttttgcaaca tttaaaatac 459360 ttattgtgta aacattgtcg agttatttca ttgtctgagg cctctattgc ttcttctgac 459420 tcctttttat gataaattgt tctctaatgt gttagaggtt tggtactgga agctcaagat 459480 tggaagggag gagtcaagct tcatctgtaa acatttctca gtgctccttc ctccagggaa 459540 gatttatttg tctttgcttc tgccagatgt ccttagaagc gaagtcacta tatgttattt 459600 tctagagtga ggtctactgg accctggaga cagtgagact acaaatccca aaccagagca 459660 aggccagtac tatggttaga cataatccct acacaaagct taggctagga aggcaagggt 459720 atttgcaaag gctgtttttt tttttttgga ggtccaatct tttagtgaag ttgtactttt 459780 ctgcagactt ctcttgtgta ggacttgtgt aggactaaca gccttccatt tcctcattgc 459840 tgttaaaact atgttttttc cccctaaatg tgcaaatgtc acagggaaat tataggtagt 459900 atcaacaaga tctttgctgt taggtattca ccccccctct tcctttatag agcccagagg 459960 gctttcctta cctgagaaac ctgctgttca tttaagtcaa tgttagattt atgcagcttg 460020 tctaagtttc ttatacctgg agagttttca aaataattag ttttttacat agtcagaaat 460080 ggaagttgct acaactcact gctgattcac tgactatatt aaactacctg aaaaaaaaat 460140 ggaaaaataa ggttccaaat aatgtaatct gacatacatt tcatgagaga aatgaccaaa 460200 acttaatcct agagggaatt ttatcttaaa atcctagagg gaattttatc taaagaaaat 460260 tcattagatg gttgtaaagc aaaaatgaaa ttaaaaaata atataaataa acgtggagtt 460320 caagaaaaac gtcactgttt ccacttttaa gtggagaagt aatttgacaa attttcattg 460380 aaagaatttt gctgatcacg agtttctatc aaaacccaag aagtgtaaac ataggaagtg 460440 cttataggtt aataaagcaa aaatcatgtg ttattaacga ggaagtgtta aggtggtgcc 460500 agatccacgg gcactcacta tttcatttct gggagcgttt ttcagcctgc agttcccaca 460560 ccacgcgtgc cgtggagctc tctgtgccac gctgcggggc ctcggtctga ccagcagggg 460620 gcaccgagtg ttctcccgca gcggcccggc gtgggcggcg gctccaaggc cgattcctca 460680 gcaccaggca ggtgcctttg aagcaaaggg cgttcattca cattcacaaa ggtctccgga 460740 acagccttgt aggttcttca actgccctca actaaagctt cggaatctga aaacctggga 460800 agaagcttag tgtcctgaca gtattttcct tttaattttg caaagtttac aaaatccatt 460860 aagaattgct ttgcaatgaa aaatatacac atttttatac tttttgtttt caagtgcttc 460920 attccattta tatttagcgg tgaggcgggc ctaggcaaaa atgaaataaa agcacagtgt 460980 taagatctgc aaggccatta aattgcagtg cacgtaatta atggaccatg atattgctta 461040 aacacaaatg tacactaatc ttgatccagc ggtactagtg atttgttgtt acagggctag 461100 atccacctaa agctcatggt gaacacttac aaccttgcac agaaagtgac tgtgcttgaa 461160 agcacgaagg caaaatccca ttggccaaag ataccttgta ttcctagctg tgaatcggtt 461220 tatcctcttt attttatact ttgcattatt ttattacttg gaagaattca cccacttttt 461280 tctgacaaag gcttatcaga tttttcttct taaaaaaata tatataaagt tttgaagaaa 461340 agacaaagca ttgcaaagag ctgtcagagg gggacgagaa gcttacaaag tgagcaggtg 461400 gcacacagcc tgtctgcagt ggtcatgtga gagccaaacc cctcagccac attaacagcc 461460 tacagcatgt gccaagccct taagaagtca catagcattt cagagaatcc cacaaaacca 461520 aaaacacaaa ttctgtcaat gcaatacata tatttctagg tagacgtatt agtacgtctc 461580 ttatgtgggt gccgaggaat cttgtaaaag tttgtgcaaa attgacgtca gttttactgc 461640 ttgtcagcag tgaaatgagt ggattcattg attcattcat ttgacaaaca tttaatgaac 461700 cactactctg tatgtgttct agggactggg aatacagcat tgaacaaaat acagaactaa 461760 atgcatgctt gatggagctt ttattgccat ggttagcatg agttacattc ataaaatata 461820 ctttattttc attaaaaaga atgagctaga tttctttata tcaacataga gagatcttaa 461880 ggaaacataa cgttggatgg gaaaagtgag tttttccatg agaaatagta aaatacttat 461940 gtaagtttga aaaacaaaga gaaaatacag aaccatacta tgtgaagttc attgtcacag 462000 ctatgtgtgg gagtgtgtgt gtaataaaat aaaaagtcga aactgggaat acacactaat 462060 atttctgata atagggtttt ttaggagaaa aatataggat ggggagggaa caaagagaaa 462120 aataaagcat tttctgtaaa gttttattta tttcattaaa aataaataaa gcaaattaca 462180 ccaaatgtta acaatgatca attttaagaa atgggtacat ggatgagtat gtcatgccta 462240 tgtgggtgat tggtactttt tcagttaaat aaataaatgg cagttggagg agggacagag 462300 aaggacatgg ggagtgagac caaacaagga tcatgatgag accagaactt ccctagagga 462360 gtggcccgtt gtgagcctga gagatcccct gtagcgacac tgagcagagc tccctgtgcc 462420 tctttccgtc ctggcctcac gctgtctggt tggctttccc gatccgtcgt ccatctctgt 462480 tgtcctgttg ttgttgttgt ggttttgaga tggggtttcg ctcttgttgc ccaggctgga 462540 gagcaatggt gcgatctcag ctcaccgcaa cctccacctc ccaaattcaa gcaattctcc 462600 tgcctcagcc tcccgagtag ctgggattac aggcatgggc caccatgcct ggctaacttt 462660 gtatttttag tagagatggg gtttcaccat gttggtcagg ctagtctcta actcctgacc 462720 tctgatgatc cacccaccta ggcctcccaa agtgctggga ttacagctgt gagccaccac 462780 gccaggcctt ctgctgtcca gttttagtaa cagctttagc aactgccttg ctctgctctc 462840 agcattctct gttttaacca tcccgatttc acctctgcct cccttatgtc taccttttgt 462900 ctcacagtct gacaatgaaa atcatctgcc actatcctag caccaacctg tgggcctccc 462960 tgaactccca cttacctggg ccacgtcagc cctgcagccc acggagctcc tccagggggt 463020 gcctctcctg tgtttccttg gctgtgatct ccaagcagag ggcaggccaa ctgcgtgttt 463080 cctagtcccc ctaagtagct tcatctttcc ctcctagcag tagaccccta tccctttctc 463140 taagaaacac tgtataaccc acctcttcca ggaagcatcg tgaacacagt acttctcaaa 463200 tctttgtcat tcatgaacta tctttatgat atctgcaatc attgaatgcc atctgtgcta 463260 gtgtttttgt cctttgaata attcttgttt acttaaaaca atgtaattat aaaaaaatgc 463320 attactactt ttaaatggaa aatcagttta actagccata cagataaatg caatacaatg 463380 aaagaaaaac aataatatta aattctagtc agatacaatt gccttccaaa gactctaaac 463440 cagcggttta cttttccttt gtctaaaaaa aaagaaaaga aagaaaaagg agactaagaa 463500 gtgttagagc aatagtgaag ataacttact tctgcaaaaa cgtgctgaga attctagtgg 463560 aggcacctaa gtcagtgagt ggataactgg taccttctgt ggctttccct ttgaaagaat 463620 cacaagaatt gagatttaca gaggagaaaa agtctcacca tgtgtccgga tatcatttct 463680 ctatagcgtc ttatcagctg cataccatca gtgggttcca ctccatttta attcatcatg 463740 gatatatcat tttcttttct tttcttttct ttttttcttt ttttagaggg agtcttgctg 463800 tgtcacccag gctggagtgc agtagtggca tgatctcagc tcactgcagc ctctgcctcc 463860 cgggttccag catttctcct gcctcagcct cctgggtagc tgggattcca ggcgcacacc 463920 accacgcccg gctaattttt gtatttttag tagagacggg ttttgccacg ttggccaggc 463980 tggtgtcgaa ttcctggcct taggtgatct gcctgcctca gcctcccaaa gtgctgggat 464040 tacaggcatg agtgacctgc ccagccagat atatcatttc caatctctct ttacatcagc 464100 gcttacgtat atccaactga cactgtttgc ctctgttttg caattgtttg cacttttact 464160 ttatggtatg tttcctttcc ttctcattag gaattagcct tttaggtaac ttggattcca 464220 ttactaggtc tgcatatgat gggcagttgc tacatgattt tattaatacc attttgttac 464280 aaaggttatt gcaaggcaat ggagtttgtg ataagctaga tctggggaag tcatttaggg 464340 aattgagtta ctctcacagt gcaaggctct gtgacatgaa agacagtctc aaagattctc 464400 atggggtcag actatttgaa accaaaaggc agtggagtgg gagtgacacg agggaccgca 464460 tctgacatgg tttctaccct tgcgtgttct tgtaagtata catatttgca tgtacatttg 464520 tatggatagc tcagtaaact cattatagtt tcctttgaca tcatcacgtg tcattgggaa 464580 acaaatgtaa tccaagacct tcaaatgatg ttgcagtttt aaaaaaataa actgctttct 464640 ctgctattcc cattataaat gcaaccaagc ctatggcctt atagacttgc tggtctcaaa 464700 gcatgtgttt gaggtgggaa aaaatgtgtc atgtccaagg aaatgataca agatatactt 464760 tgaaaataga actgatagga catagaattg gcctgaatgt caggatgagg caaaggagat 464820 gaggaccaag gcggctgcta ggtcttggtg aggagccctg aacaggtgaa gagtccccct 464880 accaggaata agaactaggg gacttgctaa agcaggaatc tttaatttaa aatgcagaaa 464940 tatttaaaga gagaacttta agaatccaag gtataccagc tgatgctaaa agacgattag 465000 ccttgctttg aaacggaagc ctagtcagaa aagtaacaat tccatcacta agatgttgaa 465060 aaaggctctt caaacatttt ttgctctgac tcacagtaag agatacatag aataaagaca 465120 ttttatctta gaactcagta atgcatacac ataaatacac acataaatat acaaacacac 465180 acataacttt atgtatgcac aggtgtactg aaacaagctg cagaatattt atcaccacta 465240 tttgatacac actgatacat tctatgctct tttatttcat ttttttaaaa agtaaagctg 465300 caatccatga aactgatttc acaacctatt agtaggtgaa cccaaagtgt gaaaaaccat 465360 tatcccataa tattaagtgg ccacaacata gtgttagttt cattctttat ggtggttcct 465420 atttttccag attctttccc ataatcctat gccatctgta tcaggtagac aaactttaca 465480 gttaattttc aatgtgtttt gccaataagc ccagtgtctt aaattccttt tgggttgcta 465540 acacagacca ggtaagcata gtcactgtgg gttgaagtgc cgtgctctga ccttccttca 465600 cttatttttt cctttttgta tgtgttgctt tttaatcagc actgtattgt gcacccacaa 465660 ctggaacaga cagtcaacct gaaatacaca ttcccttcca gccccaaaat gcagaaatct 465720 tgtgggacag taaataatgc tgatgtacct cttctaaaca tgagtccgcc tgatacaacg 465780 agcacatcca atagcattct cttccttccc ctttccatat ctctataaag ggctactttc 465840 aattccccaa agtccaaaat aagtcagcca tggacagcca gtgccacacc ccgtggttct 465900 tattcctggc aggaggactc ttcacctgtt cagggctctt caccaagacc tagcagccac 465960 cttggtcctc atcgcctttg cctcatcctg gcattcaggc gagttctatg tcctatcagt 466020 tctattttct tttttttttt tttttttttt tgagacggag tctcgctctg tcgcccaggc 466080 tggagtgcag tggcacgatc tcggctcact gcaggctccg cctcccgggt tcccgccatt 466140 ctcctgcctc agcctcccga gcagctggga ctacaggcgc ccgccaccac gcccggctaa 466200 ttttttgcat ttttagtaga gacggggttt caccgtgtta gccaggatgg tctcgatctc 466260 ctgaccttgt gatccgcccg cctcggcctc ccaaagtgct gggattacag gcgcgagcca 466320 ccgcgcccgg cctcagttct attttcaaac catatcctgt gtcagttcct tggatatgcc 466380 acagtttttc ccgcctcaaa catacttttc ctttaacctt gttcttagct ctacttatcc 466440 atgaataatc ccttcttatc ttcctacctt ctgtggctct gctgaagtgc acgtcctcag 466500 aaatccttac atacacaccc cactccaaac ccccaccatc taaacagctc ttctctttac 466560 tagagtcaac ttctgtttct caattcatgt aaatgcattt atgagagtgg atttattttc 466620 tttgtcaatg tactcttttt gtctgtgttc ccaactgaaa tatttgcttt caaatgtcag 466680 tggccaaaac catcttgttc atcgtataaa taaataaata caatttataa gttttacgag 466740 cttctttggt tctttaataa aaaattcttg aagtgattca tttaaaagta aaggaattat 466800 acaattatat tctttctaag gattcattat tttaaacaac tagaaatcta actagagcaa 466860 agattagtga cagacttgaa tatctgcaca aagatctgat cattaacaaa ctaaataggg 466920 taattaggta tacagttgga atgcagtatg caggcttaaa ttagtagtgt ataattgagc 466980 ctcatttaac tgcaggagaa tttcactgag agaattttat ttacataaaa gaaatgtctt 467040 agtgaaattg ctttgagaga atttaaaata tgtacaccaa atctctcctt acatactgga 467100 tccagcagaa ttgtaagctt attcctcatg ccccatgtga tggtgttatt tctagccaaa 467160 tgatttcttc caggcggctc aagatccacg ctggggcttc attatttctt ggatatcttg 467220 atgatactct cataaacata ataggctcca aagaaggtta aataaaatga tatggtgaga 467280 gctctgcccc ctcaatatga tcccttattt tactgatcct atttttagaa aaaaactcga 467340 agtatgtata tcttctaaac agtcacttaa tttagcactg tgcaaacctt tgggggcagc 467400 aggtaagtgg ggcaaacaag aggatccctt tgtcttcaga gaggcaactg ccattttgag 467460 gaggcagctc tgacacccaa atcaactgga ctgatgcaat tatgtgtgaa atggggaatt 467520 atcacagaag ttcaggaaga gacagagatc agctacatgg cagattcaac ttttgtgtga 467580 ggtatttgga ggggagggaa tacaaagacc agggtgaata ttgaaagtct ccccttctgc 467640 ttttaggcaa gtccaggtag cgaccagctt gaaaagcaag cataataaaa gccctctttg 467700 acgcatctac tcccgacagc aacatcatcc taaatttatc tccttctatg ttgtgtgtta 467760 catgggtttg gtttacgtct actgtgtcca tatgctcacc acccactgac atctttttcc 467820 aaaatacatt ttaactaccc aagaagcaca ttaatagagt cttcttttaa gatactcaaa 467880 tacgtgacag tgggaaatga aacataattt ctcctcccct tcctctaatc cactcatgat 467940 ttcagaggca accacagtta acatttgggc agatatctgc tgatccaggc ctctctgttc 468000 atttgcatac acaaatttat tcatatacca ctgcctttgg tacataacat tacagattgt 468060 tatgtaacca ctttagacta tgtagtggag atttttctgc agggtatgtg tacatatacc 468120 ttactgtctt ttatgtaact gcagagtata gatgtaccct aatttattta cttatttatc 468180 ccttgattgg cattcaggtt tatgtataag ttttcattgt tggccgggcg cggtggctca 468240 cgcctgtaat cccagcactt tgggaggccg aggcgggcgg atcacgaggt caggagatcg 468300 agaccatcct ggctaacacg gtgaaacccc gtctctacta aaaatacaaa aaaaattagc 468360 cgggcgtggt agcgggcgcc tgtagtccca gctactcggg aggctgaggc aggagaatgg 468420 cgtgaacctg ggaggcggag cttgcagtga gccgagatcg cgccactgca ctccagcctg 468480 ggcgacagag cgagactccg tctcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 468540 aaaaaaaaaa aaaaaaaaat aagttttcat tgttaaatta tgcatccgtg catttggggg 468600 tgaacgtcaa agtgtgcact tctgagtttt tccataggat aatctttgac gttgcaagag 468660 ggattgaaaa gtatgcaagt ctcacacttg aaatatactg gcaagttgcc cttcaaaaat 468720 caaaaggctt caccaattta catgcccacc tatagaggtt tttatttccc ataccttttg 468780 tcaagaccac ttattttcaa acattttatt ttttgttcta atctcctgta tgaaaagaat 468840 ctctcatttt aatttacatt gatttgttca agttctaagt aaattttgtt cagcaattaa 468900 ttaaaacgta attcatttca cttgtgaaaa ggtgacattt ttgcaatatt aagttgacta 468960 atcctagatt tggatatgcc tcttcattta tccagggctt ctattatgtc atttggtaat 469020 gacgtggagt gttctttaac tcaattttgt gcatttctag ctcttagaca cttaatattt 469080 ttattggttc agcaagaata ttttatcata ttttattaca gattagagct actctaaagt 469140 gcttttctct gtcaggttct tacatggatg ttcttattta atatcatgat tttcccaaaa 469200 aggcaatatt gcccctttgt acaggttgta tatgtactca aggctatggc aataggaagg 469260 cagggagctg aggccctttg cagcatcctt tagaagtcct ctcctcccct ggctttctta 469320 gcgccacact ggcttgtgtc ctccatgcct cctctcactc ctttcctggg tcttttcttg 469380 gccttcttcc ttcactcgcc ttccttcact ccccttcctg gggagttact aaacttcagt 469440 tctcatgaag ggcttctcct caacaagcat agtttggtct ccaacgccct gtctgcagct 469500 tgactttttt gattttaact gactcagcat gctcacagct gagctcttat cttttctgaa 469560 acagaatctc ccctacccca actcctttgt tctaccaagg ccaccccaac cccataggtc 469620 cctcagaatc aatacctggc atcttcttct cctcacccca gctctgttga acctttaggt 469680 taaatttctt tctgtgctca tggcttctgc cccactctgg ttgtacctcc gcttgcccat 469740 gccttgccgt ctcacacttg tgccatggcc caaacccagg ggagcgattt gcgtgagggc 469800 atgagccagc aagccagggc accatcctgg cacagatact tctagttgta taaactgggg 469860 caagtccctg aacttctctg tttctcaatt ttctcatctg aaaaatggga ataacagtat 469920 cttcctcttg gggtcattgt aagaactaaa tgtgtcataa cataaataat gccgaaagca 469980 gtggtagcct ccacctagaa cctgttggct ctgattagga ttcatgttaa tatccatgtc 470040 tctatctaaa ttttcccttt ttataaggac acaccggtca cattggatta ggggcacaca 470100 ctatccaagt atgagttcat cttaagatat tacatctgca gtgactgacc ctatttccaa 470160 ataaagtcac atcccgaggt actgcaggtt aggacattaa cataaatttt tgaggaaggg 470220 ggaaattcag ctcataacgt caggttagat gtcttctctt tagggggctc ttcttttctc 470280 ttatatgcag ctttcaacat gtgcatattt ttatctggca actcaattgc tcaggaaata 470340 tctgtagctc gttcatgcct gcatgtaatc ctttatatat atcatatata tgatatatag 470400 atatctatat aagatatata tgatatatat gatatataga tatctatata agatatatag 470460 atatcgatat ctatataaga tatatagata tcgatatcta tataagatat atagatatcg 470520 atataagata tatagatatc gatataagat atatagatat cgatataaga tatatcgata 470580 tctatataag atatatagat atcgatataa gatatataga tatctatata agatatatag 470640 atatctatat aagatatata gatatctata taagatatat agatatctat ataagatata 470700 tatgatatag atatatatat atcttctatt tccacttcta ttttagttaa tgctaagagg 470760 atcatgtggt ttctaatgct atatacttag aacttagatt taattcttat gttcctctaa 470820 tatttcagaa actgttattg aaacggcttt gaagaaagct gagtttcatg acacagtgtg 470880 gccatcaatt ggcgacggca ggcgcagctg agaaaagctt catcgtgctt gtgctaccat 470940 ttaacatctt attagcagag ccatctcttc tttcaattgc tattaactca attcatatag 471000 actgcaatag gaaaaacaca acaacaagag ctctaagata tatttctcta agtgaaaaat 471060 gacatatgct tttaaaatct tcccccaaat agtattgcct ttactgaaga tctaacagct 471120 taaccacaca gtaaaaagcc agggagcata atgaaagaat aattcatcac aatcttaaaa 471180 tatgctcatt ttcatataag aatatattca tctctggagg agaacaaact ctttttatgc 471240 agtctacatg aggaaatgtg ccgaaatcta aaaaaaggta ctttagcttt ctttttactg 471300 agacctagga aaggatgttt tgaatacaag caataataga ctgtttcatc cacccatgca 471360 tgcattcaac aaatatttta ggatgtcata gccaagtact gttctatgta atggagatga 471420 aatgttgaac aagacaaaat gagttcttgc tattctagat gaaggaggga aatgttaaac 471480 caatctcatg cacatgtaca agataacgtc acatacaggt ataataaaac caagtctctc 471540 atcatgaatg accatgatca tgtgactttg ctggaaattt gacttaaaaa ctgaggccag 471600 gatgacaaga aggacccatc cagggagaga tctgggctca gagcctccag tcagagcaat 471660 taaaagaagt acagcatggc ctgggtatgg tggaagaagg agagagtgga gtggaagctt 471720 ttggagatat ggccaaagcc caaactatca tagaccatca taagtggtta ggtctagtgg 471780 gattccatca aggcactaaa tgatgtatat tgctaaatgc tcatgcatgt tgaatagaga 471840 ttaaattgta gggaagcaga agtggacaca gagagtttga aagctacaat ccttagatgt 471900 gtgtggtaca gtgttgaggg aggaaagtgg atggattcag gatatatttt ggaggtagaa 471960 gcagagggcc ttcctgttag ataaaatatg atggacaaga aatgattaat tttgagaact 472020 tcaggatatt ttttttatac tcagatacta acagatatgc cagggagaat tgttcaagta 472080 acatgataat gattttgggg aaagtccctg agtttctgtg aatatccatt tctactgtgg 472140 aaaagacttc tgaagataat atcttggtca gcttgggcta ctatcacaaa atagcatgga 472200 ctgggaggct taaaccacaa aaatttatct ctcactgttc tggaggctgg gaagtccaag 472260 atcaaggtat tggcagattt ggtgcctgat gggggctccc ttcctggatt gcagacagcc 472320 gccttctcac tgcgatccca cagggcggaa agagaaagtg aggtctggtc ccacccttat 472380 aatcacacct atacctaatt acttcccaaa agctttattt ccaaatactg tcatattggg 472440 gattaagaat tcatcatata aattttgtgc agatgcaaac attcagttca tagcagatgt 472500 ctgtgatcct cctttcccca agcctttcac tggggtatac aaaaatactc catggactca 472560 gtatatcttt ctatgtttac caatgctctg tcatgtgaca ttggctcaga ggtttagtaa 472620 atattttgcc tgtggtgaaa tagctccaaa tggcagaatt atgatgtaaa attcatctac 472680 atcattacca ctcagatgct ttctttaata tatgcggttg cctttcataa gtaagcaaac 472740 aagcaattga aagggggccc tgctatgttt atgtcagtgg gatcttccct gtctggctca 472800 caaaggctac attttataca cctgtggatt gtccagaaca gcagaataac aaacatggca 472860 tttactagga tagataccaa tttaattttt tatttattaa tatttttttc aattgaaaag 472920 ttatatacat ttattgggta caatgtgttg attttgtatg tgtctatata tacacaccta 472980 tgtgtataca cgatgtgaaa tgattacatc aagatgatga acatatctac cacctcactt 473040 atcccttttt ttgtgatttg aaatttactc tctgagctat tttgaaatat agaatacatt 473100 attattcagc ttagtcactc tgctgtgcag tagatgcatg actatctgct agatgacata 473160 aatgcatttt aatttgatct tcaacagcag aacaaagaga ttactcatca tctctctttt 473220 ttctagatga agaaagcaaa gtttagagtt aaatgactag actgaggcca cacagctgga 473280 aagggacaag gaccgttttg tagttcagat ccactggctt ccaaagccca ggttttttct 473340 tccacactga gaaatctctc aaagtggatg agcttattgc acctcaaacc agggaaaatc 473400 ttttaatttg attcttcata agaacaagaa aaagttagct gagaagattg aacaagcaca 473460 ttaatgatga ggactttaac atataaaatt aagtatttgt attagaataa cacacaagga 473520 taaaagcagg tatggggata aataccagtt ttcctccctg ggtatcagta gccccttcat 473580 cccagggaga caaggacaat gccacttcct tgattgctct ccaggttctt cccttctatc 473640 ctttttcctc aacttcttgg gatgttccta aacccaaagg ctcaaatctg tttagattat 473700 aagctcccta gagatagggg ctgtctctct cctttttgca tttctggagc ctaggacagt 473760 gctggtccaa cgaatgggtg catcacttgg ctctgtttcc tgaccaccta taacacctgc 473820 tggtttctag aatcaactct gatgtgcctc tttctggaga tcatgcatgc ctgctttctg 473880 cggctcagat cttaaagatc tgactttcag cattaacaac ccatagttca gcaaaataga 473940 tttctagaac tgctgctatt ttaatatctg cctttgaaga aaacccaaaa tggtgttgtg 474000 cctgagtttc agaacccact gctctatgag tgttttttgc ggctcagctc cgtgacaatg 474060 ggaagaacgt ggctgtagaa ctccaaatct gagggtttct gcaacatttt cctactgggc 474120 taatgcccca ttttctttgg tagttttgtg tccctacata gaaatatccc actggcccct 474180 atgctaatct taaccaggct gactgaactg acaccaagcg ctggatttat tttagtggca 474240 ctaacatgta agctcatgtt aactgatgtt ggaaaaccac tatgttactt gctcataacc 474300 tatttactct tagtttatac aaagtcctaa aagccttgat atgtctgttt tctaactctc 474360 agcatactga atgcatcaca ctgtgtgttg acaaagatac tgataacaaa gggaagtaac 474420 atataacagc tggatagtaa aggaggaagc agaaaagcta ataaagacaa gctcagagac 474480 ttgaacatct ggcagtctgg gaccattcca tgcatcttga gatgccacat agcttctgag 474540 acatccctct ggtaactgag cagcatggct caataatcga tgtccaaaat gatgactcaa 474600 aatccaaaaa tcattccctg ttcagtaggc tctaaattgc agtgtgtcta acatgacaaa 474660 aagtatgaac tatgttttag aactgtgtcc ggttaaaatg ctaatagtat tccaaggaaa 474720 ataaaacaga aagacacaca aagggagaca gaatgagaca gaattgtgtg tttgcacttt 474780 ttgctgccaa taaattgtat ttaaacattt gcctatttta acagaagcac atccattaat 474840 cccattgaag gacatgaaca aaccatttaa tccatatgac atggaaacct ttggtggcat 474900 aaggtagcaa gtggggtaca gtggcaagtt agggagcagt taaaatgatt ccttgttacc 474960 acagggctga catatttggt gctctaatga cttagctgtg tccttgttgt cccttgatag 475020 ttccacagga ctcctgagtt gagactgtac ccaaggaccc tggacttacc tgttcctctc 475080 ataattaaaa gatcctactt ttcaacctta ttttatgttt taaaatgttg atcaatttca 475140 agatgagata aattgagaaa tgaaggacta gacaaaggag gtcaaattaa cccatttatg 475200 cctgaggttg caatttttta aatttttgca atcagacctt ggcaatgacc ttgagcagca 475260 ggaaataaat aattgccaca tgcttagcgt tccaataatg aaacgctagg cttaaatggg 475320 tttacgcaca gaaactcagt taatgtcaac tccttcattc ctgtaaacat ctcaaaaaat 475380 gcttaagaca atcaaaggtt caagttcttc tgaaatgata cgccctaaag ccttatttaa 475440 cgtaagtggg taaacgaaaa aaatgttaga tattacaaga acaaaatgtt cctagagaat 475500 agagccctct ctggaatcag taataatgca ggctgctgct atctgtgtgc atttctcaac 475560 ctttctggaa aatggcacac aaaatccttc ccacttgtat tttgccacca ctcatggcct 475620 atcaattcta atgaaaatac tccacgctaa gaaggtgaca ggaattacat acatcatctt 475680 tttttttttt tgactttcct ttctgtctat caaactgtac tttaaaggaa ctgattatta 475740 aagcattatg taagtatgca aaatatattg aaagagaaat aatgtttcca ttatacacaa 475800 tgtgtatcat aagaaaggct ggtgtgtgat gacacatgac aagtggtaaa aggtattttt 475860 agttgctttc attttgggga ataataaagc aaaattatct ggaatataca gcattaggag 475920 atttttcagc ttctctaata gctagcatta tttatggcat attttaaact aaatgtctaa 475980 ctggaattgt ttggaaagtt aatatagata ttactttaaa gatattttat actaccttta 476040 ataattaatt tgcgctcctt tgaaaagctt atacaaggtc agtatttgct ctgttatttt 476100 atgatctttt tcacatctgt gttctttgga attactccta actcatgata attcataaat 476160 catttttagg ctgggcatgg tggctcatgc ctgtaatccc actttgggag ggattacact 476220 ccctggcact ttgggaggcc aagacgggtg gatcacttga gctcatgagt tcaagaccag 476280 cctgggcaac atggtgagat ctcgtctcta taaaaaaata caaaaattag ccaggtgtga 476340 tggcccactc ccatagttcc agctattcgg gaggctgagg tggaaggatt gcttgagctc 476400 aggaggtgat ggctgcagtg agctgagatg ataccactgc accacagcct ggataataca 476460 gccagacctt atctcaaaaa aaaaaaccat aaaccatttt taatttatct gagaaactga 476520 cctatgcatg atgtgtagtt actgcagaaa atgaccaaga aattatcttt acaatttaaa 476580 tatgtaaagc tcaaaagcaa tgaagctaag actcctggaa attctgactg aaataaacta 476640 aaggatgttt caactgaacc tgagaaaaat aagcaataaa agttgattat ttggcatttt 476700 agtctttttt caaagataaa aatcacattc tttctagtgg aatcacatca catgcagaaa 476760 tagcccatag aagagtctaa cggtggcagg aggtgtactg agttacccac cgggaaggtg 476820 caatgaggca ctctcagctc tacttttttt ttttttttaa agtaaaagac cagaaatttt 476880 attatcttag ggaaattata gaatccactt acgatgatca tttacatttt acctttatgc 476940 tccaacttgt tttatcagcc aattaaaatt gaacagcgaa aaatatcttt aaaagttaca 477000 ttttcaaagg gaaaaaaaca tttttgccct cttaaactaa cactgatatt tgatctcaat 477060 gttggccctt tctgttcaac tgaagcttta ccggtaaaaa ttagaggtta cagataggac 477120 attgttttgt gctgacataa tggggaatga ctgatcatga attttttttc ttgaggtgaa 477180 aattgttatt gttagtgatt tgaacagtcc ctttaaaaat tagtgattaa gaaataacag 477240 agtattctaa aacactgaat ctgggaagaa ttgatatgtg tcatagaata tagtgataaa 477300 tattggttat taatgtgagg aaataagaca gcctttttag gggaagtttg tagaatattt 477360 tattgctttg tagtctaata tttttgtgct tttattgaaa cattttaaac tgaggcaaaa 477420 gtttatactt tcataagcta gagatgtgca acaaaaagtt aatattccct taatttgtca 477480 cattctaagg gaaatgtaat gatccaagaa aatcttctgt gttcggtata taccaattat 477540 atgacaactt cgttgctgta agataaatgc atgatctaaa aaaaagttta tgaggttaga 477600 tttgctaagt atatatttat tgtatagcat aaggactaaa aacccttaat gtaggctagt 477660 caaaaaatta aaacagcttg gacccttaat tgacacacac acacacacac acacacacac 477720 acacacacgc agacgcacgc acccattttt agccttttca ttaagtttct tcaggtgggg 477780 gaaaaaaaaa actgtttaag gactttgtct gtgtggttgg gttgctttca ttgtctttta 477840 accaagccac tgttttcctc tatttcagga tctagatttc tcatcacatc cacgggagcc 477900 ttgtatatta aagatgtaca gaatgaagat ggattgtata actaccgctg catcacgcgg 477960 catcgataca ccggagagac gaggcagagc aacagcgcca gactttttgt atcaggtaaa 478020 aacttatcaa gactctgtct gctatgtctg ctatttcttt gttagtgtcc tgagacgact 478080 caatcaaaat tgtggagtgt tgccactaaa atggagcctt caattccttt tccaaaatat 478140 tttaggaatt ttaaaactct tttaaatgaa tatgagtaca atttcataga aatacagatt 478200 tcacatttgt caaaccagta attgacacat tcacataatg atgcgttagc atttcaggga 478260 gcacattagg agtgaaagat ccatctccat cccaaatatc catctcaaat gcagtcaaat 478320 tgcatttgat ttgattataa aaccaaatac aaaataccca acctttgcct ttgtagctga 478380 agaatataaa attgcccccc tgtggtaaat atcctataag gttgtaatag tgagatggaa 478440 gtgaccaaag gttgcttgct atcaatattt gagaagtacc ttatttgtaa taatgcttta 478500 tgggaagaag tgaagggaac ttgttgaaca ttggaataat ttaaaacatc actgcctgag 478560 cacccacttt ttgtccttga taatgtactg ttgggatttt tctcttcatc acttacatct 478620 tcaaaatagc caatagtctt tcaaggtcca gcacaaatac aagtcagaat taaattagtt 478680 ttcctttgaa cttgcaagta tttttgtttc tttatctgtt cttttacaag tcaattgcta 478740 ttttctccct tgcttttata gttatcatgt cttttggggg aaaaatgaat tagaaaatga 478800 ataataacta tcatcttagt ccatgatagc tttaaggaga gcacaatatt ctgcttattc 478860 agaaaatcct agaaaacgtc ctctttgtgt taaagagaaa ttttctaatg gcatgttcag 478920 aaaagaaagg ggaaggattc gaggtaggag ggggatcctg atataaaatt aatttgggat 478980 tcgcaaaatt agtaaataag catttctccc tccaaatgat gacataagtg gtgatgatct 479040 aagagcccgt ctttctgttt caggtgacct tttttatctt catgctgaat catcaagtgt 479100 tgatttttaa atgtatctct cagggttgga aaggcaagtt tactttcctt aatcccacga 479160 tgtttgttca ttttttgttt tggagtgatt cactaatgtt tcaaaaatgg acagaagtag 479220 tcacaagcat tttgtcacca tgggagtcct aggattgcct agtgagcatt ggaaaagtga 479280 gagcaacaat gtataatcca gccagggaat atcatacact aagccacctg ccgaaaagta 479340 gccaaggaat aagactgagc attcaggact aacagtatag atgaagacag ggaggtgata 479400 gatgccagga gaagggaggg gtccacagag tcacatgcca caaaaaggct catatgagag 479460 tctaccatat gtggaaaata actcaatatt ttttgtcatt gaaattttaa taaagcagtt 479520 gaggaagaaa tttgttaatg ctaaaagatg agactgtaga cactgaatac agaatgcatt 479580 tctaacatgt caagctttga aggaaaagag aaattaattt cattttaaat tagatttaaa 479640 tatactgaaa aatgtacatc tggagtttgg gtcatggtgg aaacatgttg gtgtttgacc 479700 ccaaactcct cctgaaacca acacagataa aataggatga caaagaaaaa agtacatgga 479760 tggcaccttc aacacaactg gattactggc aacaacagga ccagcagcag aggtggaagg 479820 cagtagaagg ggtcagcctg ttgggtttat ggtagtgtca gaaaactgca aataaccaac 479880 gggtccccat ctccaaaagc agaggagaat tctttgtgtc ttagagtcct cacaacactg 479940 ggatagaact gcatgaggtc taggttggag atgagtcaca aggccattag agtggctggt 480000 aatgtttgca caggccagtg atggtctatg tccttgaaga tagtggaagt actcagcaag 480060 tactcctttc agaagaacag agactcactc tcaggggaac ggctcaattt agaaatcaaa 480120 ttgagccaga gtagaataca aagagtaaca gagaaggctc gggaaccagg ggaggcccta 480180 gagaattcca tcctatgaaa tactgcaaaa gaaaatacaa cacgcacagc cttagaatgt 480240 aaaaaacagt gttctaggaa acacatggcc agaagtggaa gcccatacag ttcaatccca 480300 tatagctctg agagatgggc taaatgtcga gtccttgaag gtaatatcaa gggagaagac 480360 tggaaaaata tactcatttc atcctctcct gcaggaacct tctcctaatt aactaagaat 480420 ctctatctta ttgtaaaatg aaacaaaaag gaaaaagatt taacccaaca caactttatc 480480 acaagaaaaa gaatgaaaat ttttaaaaaa gttttgatta taagtaacta caaaaaatac 480540 tgacaaatca tatgaaaact atattttttt gtttgaaatg attaaagctt tgaaagagca 480600 gtataaatca gaaataaaat gatgaaacaa cacaaatctg tgaaacaaaa agtggcatat 480660 tttggaaaaa gttagaaaaa tgaagagttc taaaattaaa atgaaatgac agggaacaca 480720 tcagaggata aacacaacag aaagcataat atgggaaatc aaaaatatta aggaataaga 480780 caaatagagt taaaaatgta tagatgtctg acaaagatga tgaaacacat gtataactaa 480840 attctcttaa aaagaaagcc aagcaattga tgagaataag tattaataat aaaacactaa 480900 ttcaaaaaaa gtctcctgtc attaaaaaga atgcataatg actacatatt aaaatggcac 480960 aaccctacct ggaaaaatgg acccagaatg gtcaacatgc aacatagtct aataaaattt 481020 ttgagctgta aagataaaga aaaatatcat ttagacagcc agaaaataag ttcaagttac 481080 ttctaaggga gaatataaac agactaatga aatagaaaat agaccaaaag aacagtaaat 481140 gtaataaaca agttttttct ttaaaaaaaa agtcagtaaa atagacaaac tgacctaata 481200 ttttttaaaa tggtcttgat ttctgtgcta gggctagtta tttggacaag tcattctttc 481260 tctgaggata actagaaaga cttgttaaat gtgtaaaaaa catctgctca tggctgttag 481320 gagctagagt gaaaacttac aggaccaaat tccagaggaa aacagccaca agaagtgagt 481380 ttggtattga ggactgcctt ttcagtaggg acagttttag aggagattgc tgaaactccg 481440 agaagatgag caactcttct gaaaggttag tagtgtctag aaggtaaaaa ttggagtcta 481500 gtctctatat atgtattagg gttctttagg gggacagaat taataggata gatgtatata 481560 taaagtagag tttattaagg agtaatgact cacgtgatca caaggtaaag tcccacaata 481620 ggccgtctgc aagctgagga gaaagaaagt cagtctaatt cccaaaacct tcaaagtagg 481680 gaagccaaca gtgcaccctt cagtctgtgg tcgaaggtcc aagcgtctaa aagttgaaga 481740 acttggagtc tgatgctcaa gggcaggaag catccagcac gggagaaaga tgtaggctgg 481800 aggactaagc cagtctagtc tttccatgtt cctctgcctg cttttatcct agccatactg 481860 gcagttgatt aatggtgccc acccagattg agggtgggtc tgcctctccc agttcactga 481920 ctcaaatgtt aatctccttt ggtgacaccc tcacagacac acccaggaac aatactttgc 481980 atccttcaat ccaattaagt tgacactcaa tattaatcat cacattaaat atatttgttt 482040 atatattata tattatagat actcattttt atttatagta gcatatatag tgggataagt 482100 gaaaagtgat tatgtttatg ttatttttat ttttattttc agtataagag aaaaataaaa 482160 gtatgaaatt cttttataat tcttgaaaat ttatagaaat tcttgaaata taacaaaaat 482220 gtaaggcatt tatacaactg aaataattat ttctaaatac tttacatatg tactttttat 482280 cctaagctct aagagaacag atgtgcctta gtgtgtatat atatgtatgt gtgtatatat 482340 atatatatat atgtatatat actagtgtgt gtatatatat atatgtatat atactactgt 482400 gtgtgtatat atatatatat atacactttt ttttaattgt actttaagtt ttagggtaca 482460 cgtgcataac gtacaggtat gttacatatg tatatatgtg ccatgttggt gtgctgcacc 482520 cattaactcg tcatttaaca ttaggtatat ctcccagtgc tatccctccc ccctcccccc 482580 atcccacaac aggccccggt gtgtgatgtt ccccttcctg tgtccatgtg ttctcattgt 482640 tcaattccca cctatgagtg agaacatgcg gtgtttggtt ttttgtcctt gcgacagttt 482700 gctgagaatg atggtttcca gcttcatcta tgtccctaca aaggacatga actcatcatt 482760 ttttatggct gcatagtatt ccatggtgta tatgtgccac tttttcttaa tccagtctat 482820 cattgttggg catttgggtt ggttccaagt ctttgctatt gtgaataatg cctcaataaa 482880 catacgtgtg catgtgtctt tatagcagca tgatttatat tactttgggt atatacccag 482940 taatgggatg gctgggtcaa atggtatttc tagttctcga tccctgagga atcgccacac 483000 tgactttcac aatgtttgaa ctagtttaca gtcccaccaa cagtgtaaaa gtgttcctat 483060 ttctccacat cctctccagc acctgttgtt tcctgacttt ttaatgatca ccattctaac 483120 tggtgtaaga tggtatctca ttgtggtttt gatttgcatt tctctaatgg ccagtgatga 483180 tgagcatttt ttcatgtgtc ttttggctgc ataaatgtct tcttttgaga agtgtctgtt 483240 catatccttt gcccacttgt tgatggtgtt gtttgttttt cttgtaaatt tgtttgagtt 483300 cattgtagat tctggatatt agccctttgt cagatgagta gattgcaaaa attttctcct 483360 attctgtagg ttgcctgttc actctgatgg tagtttcttt tgctgtgcag aagatcttta 483420 gtttaattag atcccatttg tcaattttgg cttttgttgg cattgctttt ggtgttttag 483480 acatgaagtc ctttccctaa attttaaaaa atgcataaaa tccttgaaat gtcaaattcc 483540 aatagaaact attggtattt gtggtatgcg tggtggctca cacctgtaat ctcagcactt 483600 tgggagaccg aggcaggcag accacttgag gtcaggagtt caagaccagc ctggctaaca 483660 tgatgaaacc ccatctctac taaaaataca aaaattaccc aggtatagtg gtgggtgcct 483720 gtaatcccag ctactcagga ggctgaggca ggagaattgc ttgaactcag gaggcagagg 483780 ttgcagtgag ccaagatggc accattgcac tccagcctgg tgacaagagt gaacttccat 483840 ctcaaaaaaa aaaaaaaaaa agaacacaaa aaactattgg tacacacttc aaaaaaaaag 483900 tatgaatttt cagtctttcc actgagaagt cccagaagtg atgagcaaac aatagcaaca 483960 agcccctcta acatctagat tgtagattct tttaaatata attcactact aaaagggacc 484020 atggcttctt ggaggagtgg ctgattgaag gtctgaggca ggaaatgtct gaggtgagtc 484080 tgaaacatga atggggtctt gtcaaaatga cataggaatc aacataaagc ggctctcgtc 484140 agccaaaggg gatgaattga gtatcagcag tgatgcttgc acatgattga taaccattaa 484200 atattttgaa aacctttgag ttcattttaa ttttatacat acatgtgtgt gtatatatag 484260 atatatacac atatgtacat atatacttac atatgcacac ctgcatatat atttcatata 484320 aagaaagaaa gaagaatctt attggtctgc atagtagaaa ccagggcact aactcttcat 484380 tctgataaca gatgattaaa gacaacaacc actaaatgta ttgtctttcc tatagctgct 484440 gtattttaag ataaccaaat aaccttagtt cagaagggaa agttcattct gcagaataat 484500 tatatctact gaatgcgaac gaaatgacac aattagaaaa ttccattttc aaccttagca 484560 aaatagctca gataaatttt aacatctgac ctcactgaac aattgagtgt cactaagaac 484620 gggaaaacca tacattttgt ggaagcaatg tgaagtgcac agcacccctc tcaaagagag 484680 agaggttgaa cacttatcta accaacccac tgaaataaat tccagttcat aagaaaaatg 484740 cctatggcaa taacggaaca agttaaatga tgacatggac aagcaaattc agcatggtaa 484800 ctacctggtt tctttttttt tattattatt atactttaag ttttagggta catatgctgc 484860 tataaagaca catgcacacg tatgtttatt gcggcactat tcacaatagc aaagacttgg 484920 aaccaaccca aatgtccaac aatgatagac tggattaaga aaacgtggca catatacacc 484980 atggaatact atgcagccat aaaaaatgat gagttcatgt cctttgtagg gacatggatg 485040 aaattggaaa tcatcattct cagtaaacta tcgcaaggac aaaaaaccaa acaccgcatg 485100 ttctcactca tagatgggaa ttgaacaatg agaacacatg gacacaggag ggggaacatc 485160 atacctggtt tctttaaaaa gccaagtcaa atacatggga gaaaggagga gggctagctc 485220 tgcattaaga aacactcaag agatgtaaca actgcatgtg agcaagagaa ggatcttgat 485280 ttaattaatt caattgttta aaagctagcc acttttgagc tgatgaggaa aaatgaattg 485340 ggagtgtata atacttgata ttatgtaata ctgactgtgg ttatgtaaca aaaccgtatt 485400 tttattaggg aaacatgcta gtcatgtaat gataaaatga catagcttcc cttttttgtt 485460 ttttgttgtt gtttgtttgt ttgtttgttt gtttttgaga tggagtctca ctctgttgcc 485520 acactggagt gcagtggtac aatctcagct cacttcgatc tctgcctccc gggttcaagt 485580 gattcccctg cctcagcctc ctgagtagct gggactacag gcatgcacca ccacacccag 485640 ctaatttttt gtgttttagt agagacaggg tttcaccatg ttggccagga tgggctcgat 485700 ctcctgacct tgtgatcccc ctgcctcggc ctcccaaagt gctgggatta caggcgtgag 485760 ccgctgcacc cagcctatag tttccctttt gttgcatata ctttaccacc aaaaacaaag 485820 taaaactatc aagaaataaa catgacgaaa aatagaaaag gtttggtgcc agagccatta 485880 atatgatgaa tatatgggat gcgtcatatt atttttgtct acttttctgt acgttttcaa 485940 atgtttgggg taaaaataat ttttgtaata tatatatata tataaaagtt tgaagacttt 486000 gagacaaaaa aaaatttgaa ggggatgaaa atgaaagaca atgccgttcg gttattcaga 486060 tttgatatat gaccaaatat ccccacaaga gcctgtctca agcattgctt caatcatgca 486120 cttaaaatat aaaacatcag atgctgtgag ggtgcagaga aaagggaaca cttatacact 486180 actggtggta aagtaactta gtcctgccat tgtggaaagc agactggaga tttctcaaag 486240 aacttaaaat agagctacca tttgacccag caatcccatt actgagtaat atatccaaaa 486300 gaaaataaat cattcttcca aaaagacata tgcacttgta tgttcatcgc tgggctattc 486360 acaatagcaa agacatgaaa tcagcccagg tgtccatcaa tggtagattg gataaataaa 486420 atgtggtaca tatacaccat ggtatactgg aaagccataa aaaagaatga aatctcattc 486480 tttgcagcaa tgtggatgga gctggaggcc ataattctta gtaaattaac ataggaacag 486540 aaaaccaagt acctcatgtt ctcacttata agtaagagct aaatattgac cacacatgga 486600 cacaaataca ggaacaatag acactgtgga cactagactg tggaaggcag agagtttagg 486660 ttaaaaagct acctatcaag ggccaggcac agtggctcac acctgtaatc ccagcacttt 486720 gggaggccta gatgggcgga tcacaaggtc aggagataga gaccatcctg gctaacacgg 486780 tgaaaccccg cctctagtaa aaatacaaaa aaaattagcc gggcgtggtg gtaggcgcct 486840 gtagtcccag ctactcggga ggctaaggca ggagaatggt gtgaaccccg ggaggcagag 486900 cttgcagtga gctaagatca cgccactgca ctctagcgtg ggcaactgag cgagactctg 486960 tctcaaaaaa aaaaaaaaaa aaaaaaaaaa gactacctat gaagtaccat gctcactacc 487020 tgaggaacag gatctctact ccaaacctca gcatcacgta atattcccat gtaacaaatc 487080 tgcacatata ccgcctatat ctaaaataaa agttgaaata aaaaaataaa tacctcattc 487140 aggtttcgta aaacagtttt gttgagaggt agtttacttt aatataaact ccatccggtt 487200 tattcaattc aataatttta gtaaatgcat ggagtcgtgc cacaattacg ccaatttaat 487260 tttagaatat tttcaccacc caaaagattc ctcctacccg tttgaagcca atttcaatgt 487320 ccatccccag tcccagacaa ccactaatct atggtctgtc tctgtagagt tgcattttct 487380 ggatatttca cataaattga tatatggatt ttgtgtctgc cttctttcat gcagcaccca 487440 tgttgttaca tgtattagtc attcattctc tcttgttgct ggagagcatt tgctcatctg 487500 taaatactgc atttggttat caattcacta aattatgaat atttgggttg tttccacttt 487560 ttgattatga ataatcctgc tatggacatt tgtacctaag tctttgagtg aacatgtttt 487620 cattcattta gggtagatac ctagaacttg gggccttatg gcaaattgaa gtttaaacac 487680 tttaagaaaa tgccaacttg ttttggctgc ttttatttgg caagtatacc acaatacacc 487740 tggggaaaaa ataaactcta gccaatgtga tgtaagagga gaaaaatgtg tgggtttgta 487800 ggaaattctg cttaaaagtg acttcactga gggggcattc ttaagcattt ttgctgtgat 487860 gtggatgtga aggctggcac tccagcaagc catttttacg tgagatgtat atgtgtgcat 487920 atgtaagtat atattacctt ccaccaacga tgtatgaaga ttccaggtcc ccatatcttc 487980 accagcattg tttgtgattt tattgcagtc atcctaatgg gtgtgaagtc atgtcttact 488040 gtgattttaa ttcatattac cctaatgcct agtaatattg agcatctttt tgtgtactga 488100 ttaggtattt gtgtatcttc tttggtgatg taaaatagtc aactattttg cccattttga 488160 ttgggttgtt tcttttcatt atagagatat aagcattttt aatatttttt ggatttgagt 488220 tctttattag aaatatgatt ttcaattttt tttcactttc taaatggtgc ctttgaaaat 488280 gctacagttc ttaatttttt tttttttttt tcgagatgga gtcttgcttt gttgcccagg 488340 ctggaatgca gtggcatgat cttggctcac tgcaacctcc gcttcccggg ttcaagctat 488400 tatcctgcct ctgcctgtag ctgggattac aggctcatgc caccacacct ggctaatttt 488460 tgtattttta gtagagacgg ggttccacca tgttggccag gctcgtcttg aactcttcac 488520 ctcatgtgat ctgcctgcct cggcctccca gagtgctggg attacaggcg tgagtcaccg 488580 cactgggcca gttcttaatt ttgaagaagt ttattatgtt gattttttct gtttttgctt 488640 gttttcttag tgttatgcct aagaactctt caaggtcatg aagatatttt ccctatgttt 488700 tcttctaaaa gtttttatag ttttagctgt tatatttagg ccataatcca ttttgagtta 488760 atttttgtag gtagtgtgag gcaaggttct aaattatttt ccatgtggat atccagttgt 488820 ctcagccatt ttttaaaaat gtcattagaa ttacatagca ctatcttaag catatttgag 488880 aaatttctgc caagtttcag ttagaataaa actttttaag tgcagtcatt gagagttgat 488940 tttttatgaa tagcattaga agttggtgca tttcattttc agagattgtg ggattattct 489000 gcaaagaaag tcagaggtgc acactgtggt gtttattgtc agccacccct gccaaagggg 489060 tgacatcttt gtgccacctt ctccaactct acttctactt cctactctaa gtaaaatgac 489120 agattttgca gctatttttt catagtactt tctaatatct tcaatattcc actctagtgt 489180 aactaaaatc tgtattactg aagaacgaga gctatcatta tattctcaca ttttttgttt 489240 ttgttttttt ttattatact ttaagtttta gggtacatgt gcacaacgtg caggttcgtt 489300 acatatatat acatgtgcca tgttgttgtg ctgcacccat taactcgtta tttaacatta 489360 ggtatatctc ctaatgctat ctctcccccc tccccgcacc ccacaacagg ccctggtgtg 489420 tgatgttccc cttcctgtgt ccaattctca catttcttaa ttaaatgaag acagagttca 489480 gaataataga gaagcttacc ccaagtaata catattatct tggatgtgat ttctacttac 489540 taaacaatat tgcaatggtg tttatatggt ctgcaagtta gtgtactagg aattaaaaaa 489600 tcccatgtgg ttaaggatgt ccaggaccat ttctggagct ggctttaggc acaactttgt 489660 gtcttctagt tcactgaacc cattgggtgt gcaggtgatg atacttccag taacatggat 489720 gcagacagct aaccattttt ctggattctt ggttcatgct agaagatgcc agagatcagt 489780 gagacatcat tggttaggcc tgtctccact taattattca gtctatggga acataacttg 489840 atcttcaaac caatactttt caaagtccgt ttgtaatttc ctttagaagc aggtaaatga 489900 agcaatgaag tttttgctgg cacaggctct gtacctgggt attgtgaaac ttttatatct 489960 ctcttgcctt ctggagccct atagtcatgc atatgaatga ctgtaattct ggaatataga 490020 attcttcagt taatgaagaa ttagaggagt cctggaagct catcaagtat tctttaaaag 490080 agtatttagg ttccctcatt atatcactgt cataagacac cagtgaagta aaaagagcag 490140 caagttcata atgaagtttt atctctgatg atcacaaaag aaatagaaag ccaagacatt 490200 tcagctaaat gtttttgttc tattttcaac agtgcctgct gactgccctc agtggctgac 490260 tacggaatca cagcctctta aagaagtctt cctactaata aatgattttt tgatgttatt 490320 gtttattaaa acagaaattt actctcttgt atataagtcc agaagctggt ttgccagctt 490380 cagtttcaca agggaccagg cttttatctt tctgatccat tatcctcacg tgcagttcca 490440 ttctcaatat gatttcaaag tccaaagtga ttgctgcagc tcctaccttt atatccacct 490500 tccaggtgat gtaaagaagc aaaggaaaaa tgcataaaaa cacccctccc agctaagtcg 490560 cctttaagca gaatttccta caaatccaca cattttcgcc tgttacatct ccttggctag 490620 agtttatttt tcctccaggt taattgaggt attgaaaaat gaaaattgta tatatttaag 490680 gtatacaatg tgatgtacaa tgtgcatata tatatatata tatatcacta tcaagcaaaa 490740 taacatatct attgcctcac atagttaaca tttgtgtgtg tatgtatgta tgtgtgtgta 490800 tgtgatgaca atgtttaaga tcaactgtct ttgcaaattt caagtatgta agatagtgtt 490860 attaactgta gtcactgtgc tgcatagtaa acctctagaa tctattcatc tggcataact 490920 gaagctttgt acccttttac ctaccatatg atctagcaat cccactctgg gtatatatcc 490980 aaaggaaatg aaattacata tctgcactcc catgtttatt gcagaatcat tcgcaacagc 491040 cagaatatga aaaaaactta agtgttgata tacatataca cacatgcata ggaatatcat 491100 tcctatatac acaaaggaat attattcagc cttaaaaaag gaagcaaatc ttcccatttg 491160 caatgacatg gatgaacctg aagggcattg tgcttagtga agtaagccac gcacagaaag 491220 acaaacactg tcttttctca catacatgtg aaatctaaaa aagtcaaact cagagaagca 491280 gggaatagag atgttcgtca aaattacaaa gttccagatg gctctcattt gataggacag 491340 tgaatatcca ttccttggcc atcagattta ttgcaggtag atcaaaagag tcatggcatt 491400 tttctcactg aggcaaagac aagaaaattt caggtagcag gagtctataa cgtttctgta 491460 atatccatgt ggaatgcaag ggtattgttt catgcaagtt ctaaacaggt tgaattagaa 491520 gagagagcag ggtgagaaca ctgagtttta cgtttagcat ccaatcaggt gctgtatttt 491580 atattcttca tagtcatgca aagattatga ccttgggaac atcactccat tcaaacaaac 491640 ttgaaggaca ttgagctgcg tggtttccac agacccagtt cttgagaata ttttatcaat 491700 ttcctcacct ggttcaagat gatgtcacag aacaggaaaa ttatacaagg ccctgtcata 491760 agtgatcatt tgcaagctgc tgctttttaa tccattgtct tgctacgcca catgctgtcg 491820 gtagtgctca ttcaccttat ctcaaatacc atcttctcag agagtctgtc cctgaggacc 491880 atatcttgag tcctcctggc tgcctccaca cccatagcac gtggacttca ctctctgtta 491940 tgccctcttt ttctttcttt aactacactt attacaaact aaattatctt tatttgcttg 492000 ctaatgtgtt gcttgctccc caacaccacc cgcccaacag aacatgagct ccaggaagac 492060 acctgtctca tccaccactc tccctttagt ccctaactct gtgctggtct acactgaggg 492120 atcaaaacat atttgtgaaa tgaataaata aaatgtttta aaattcaaaa gctatgtgta 492180 aaactctttt gtgcaataaa ttttactaaa gttaaacagc tatttctgct tatgttgctc 492240 tttttttttt tttttttttt tttttgagac agagtttctc tctttcaccc aggccggact 492300 gcagtggcgc tatctcggct cactgcaagc tctgcctccc aggttcatgc cattctcctg 492360 cctcagcctc ccgagtagct gggactacag gcgcccgcca ccacacccag ctaatttttt 492420 gtatttttag tagagacggg gtttcaccgt gttagccggg atggtctcga tctcctaacc 492480 tcgtgatctg cctgccttgg cctcccaaag tgctgggatt acaggcctga gccaccatgc 492540 ccggcctagt gttgctcttt ttttctgttt aaatttattt aggctgggtg tggtggtgca 492600 tgcctgtaat cccagcatgt tgggaggccc aggcaggagg atcacttgag cccaggagtt 492660 tgagactgtg gtgagcaatc attgcaccac tgcactccag cctgagctac agagtgagcc 492720 actaacttaa aaaatattta ttttattaat tttatgatat tttattgatg cataatagat 492780 atatagtttg gggtacatgt gataatttaa tgtattcata taatttgtta aaatcaaatc 492840 agtgtacttg ggatatccat cacattatat gtttggcttt tctttaagct ataattattt 492900 caattcttct gttttagcta ttttgaaata tacaatacat aattgcaaac catagtcatt 492960 ccactgatct gtctaccact aggtcttatt tcttatctca aattgcatat ttgtacccat 493020 taaggatctt ttaaagagaa ttctgacatt cccagttatg aaaagacaat ctgatttttg 493080 gcctgagctg acagctcttg ttgaagcctg ctcattctgg atcttttatt catttactga 493140 ggaatgacca acagaagctc tgaccagtgt tcaacctttt gtaaattctg agcagaaaat 493200 aaattgtatg aatagggcac ttctttttct gttcacttat aaaatcttaa agatctgtat 493260 caatagttgg tatgatgcac cgtatttaag ttatacatga agtcctacaa ttctaaatga 493320 ccacttcaac tcctcattcc tgcctctaag agtttttatt tcttctacag acccagcgaa 493380 ctcagcccca tccatactgg atgggtttga ccatcgcaaa gccatggctg ggcagcgtgt 493440 ggagctgcct tgcaaagcgc tcgggcaccc tgagccagat taccgctggc tgaaggacaa 493500 catgcccctg gaactttcag ggaggttcca gaagaccgtg acggggctgc tcattgagaa 493560 cattcgcccc tcggactcag gcagctatgt ttgtgaagtg tccaacagat acggaactgc 493620 taaggtgata ggccgcctgt acgtgaaacg taagttggac ggtaacttgc aaaggtggtg 493680 ttggcttcca tcgatggagc tcctgttata agcaaatctc catgttttct ctgtagcttt 493740 ccattaactc ccaaaacagt ccagctgaga tcaacagaaa cctcatttta cagatgtgaa 493800 aattaatgct cagatgaatt ccccaaggtt acacaactgg agagtcttgg ctgtcggatt 493860 tgatttgaaa tctttctgat ccccaaacct ctgtgatttc cattaggcca cagactatta 493920 catttccaag atatgatttc aagataacac ttcctagctg atgaattcac aacaaccagt 493980 ctctctaaaa atgaacagag agagagggta ggattgttct ttcagcacaa gtgatggtag 494040 ccaatcaaag cagttgtcct ttgtctgttt ccagaccatt tctccattaa atttctaaat 494100 gaggctatta tcacccaaag tacggggctc aaacataccc aaatattaga cttgtgccta 494160 gtattataga tcatctactc caaatataat ggatttattt gatcttctat tgattgcctt 494220 ggctgccttg aggaatgtgt tcagaaggat actgaaggca gatttggagg aaggagggat 494280 gtgatcgcag ggtcacaatc taatctactc aaccaccctc aattttgctc ttgcagaaac 494340 caaattaaag tgaattaccc aagatcacat ggccagaaaa gggaggcaga gcattggtca 494400 gagaggaggt cttagttgcc aatataatgc tccttttttg aaaatatatt tttatttgat 494460 gaactaaatt gaacaaattt aaccacaaga atctcacagt gacaatagaa gtgttttctt 494520 acttcctcct ccccacccag ccctaaccct gtttatggaa ctttctcttc agtgtcaacc 494580 tgagtgtaga ctgccttagc gcaacaccag cctaagagaa tatatttata ttaaatatcc 494640 aaatgactct ctatctggaa caggctgtcc agcctgaatc ctgcaaatat ttgaatatgt 494700 ttagtctggg attagaaaga aatggatgat aaaatccaca gtcacacttc tatagctgaa 494760 gaatcatgtg gataaaataa tgcagcattg gacagccagt aagaattatt cccacgggct 494820 caaagtctct tctgtgttta aagacctctc ctagctccct gttctccatt gaataaagtt 494880 tatatcttag gatagtactg aaggcatctc aagcaaatct gtctggttgt atttcccatt 494940 gttttgcatt aaaacccact tatgactagt gttccattat tggaacacta agcatgtggg 495000 agttatttac atcctactgt gcaaggtcat caccaaggtc tgattgcaaa aattcaaaaa 495060 aaattgcaac ctcaggcata aatgggttaa taaaaaccta ttcctgctaa atctaacttc 495120 ttcctaatcc ctgcacaaac ctattccttt cctgattgca agtcacatta cttatgttgc 495180 ttcctccaca tggaagatta tttcccaata cttggttatc taacacttcc caactctctt 495240 agcctccatc cacaaagatg tgttgttccc cattctcctg tctccttctc aactcagagt 495300 atgttactgc tttctctcta aaggcgttta tcactaccta tattttaaaa gcctttattc 495360 ttaatgtgct tatttttatc attgttccct tcttccacat ctaggtgatt ctccaatgct 495420 tctggaatat tctctgcctc ccttctgact gcttcttcta actgcagaag aaaacagctt 495480 cttcgttcct atctctcttc tctattggaa ggcattctct tgggctccaa attcagaact 495540 gtcttcttgt caagctcttc ccttttcctt aggctctgtt tcatttgtag agcttcgaat 495600 tccttgcccc tgaaaataag ctctgaatct gtacttacag ccttggcgtc cttcctgaat 495660 gtcagacaag tgtgtcaacc agctttcttt cagaaattta gttggcactt caaaacaaca 495720 gggtcggata ccaaactgaa ctctccacca cctcttcctt ccaaatggct cttgttatta 495780 ttatcaacat cttcctcctt ctcatccctc agatgcaaac atgaaatgtt gggtgccctt 495840 taagcctttc ctttctacat cctgccaagt cctgccatgt cctgccaagt catacaaact 495900 gaatctcaca gttactcagc tctgttctca acctctgtcc tgtcctagat tggatcttaa 495960 ttgtacctac actagacatg tgtaatgtct tcaatgacgg gttttcctca ccctaatttg 496020 tcaaaagacc tatgacctag tgattccatt aaaagtatgt ttgtgctggg tgtgatggct 496080 tgtgtctgta gtcccagcta cccaggaggc tgaggcagaa agggagagga gtttcaggct 496140 acagaaactc ctctgtatga ttgtgccact gcactccagc ctaggtgaca gagcaaggcc 496200 ccaattctaa aaaaaaaaaa aaaaaaaaaa aaaaaagtat gacttatttg ctaaacactt 496260 ttgaatgcct tctttagtta tctttgttta attccaaaat ctcagggact ctctgttgca 496320 tccaaaatga atcagaaatt ctcagacatg cccctgctcc ctgccttaat tcatgtggtt 496380 cccaatctct gtgattccct ctttccattc tgactgatct cagttctatg cacccttgat 496440 atctgtggat ttcctgctct tcccatccac cctcctccac atgtgctatg tctctaatgg 496500 cccctccatc actctggttg gttattacag ccatttattg cctttgtctt atcaacctag 496560 aagactgagc tccttgaaaa caaagtgtgg tgagatgaaa agttaggaac aactggggta 496620 aaaaaaagct tttttttcac ccactttttg atggggttgt ttgttttttt ccttgtaaat 496680 ttgtttaagt tccttgtaga ctctggatat tagaccttag tcagatggat agattgcaaa 496740 aattttctcc cattctgtag gttgcctgtt cattctgata gtttcttttg ctgagtaagt 496800 agaagcttat tagtttaatt agatcccatt tgtcaatttt ggcttttgtt gcaattgctt 496860 ttggtgtttt agtcatgaag tctttgtcca tgcatatgtc ctgaatggta ttgactaggt 496920 tttcttctag cgtttctatg gttttaggtt ttacatttaa gtctttaatc catcttgagt 496980 taattttcgt ataaggtgta aacaaacctg taggttcagc gcatgtatcc cagaacttaa 497040 agtgaaataa ataataataa taataatagg agaagattac cagaatggat taaaaagcaa 497100 atcttagcca tctgccatct acaagagatg tttgttaatt taaaagatat atttatatgt 497160 cttctggcct ccatttgctt ctgctaaaca atcagaggtc attcagatct ttgtttctct 497220 gtatgtcatt tgccattttt gctgtctgct ttaaagaatt tctctttatt tttcgttttc 497280 cataatttgt aatatgacta gacaggattt tcatcagatt ttctctgctc agcactttct 497340 gacctttaaa aatctgtaac tgtaggtctt tcaccaaaaa ttttgttttg ttttgttttg 497400 atttgccatt tacctgttga ttggatttgg ctgagttatt taagcgctct caataactat 497460 tttctgtttt gtaaaataga gataacacaa aaattacagg attaggagaa gactgactta 497520 aatgatgtat gaaagatagt cgataatttt atagcacaag ctagctgcac cacaaatatt 497580 attccatttt tcttgcctgt gagtttaacc tcatccttgg catatgacag atgctcagta 497640 aatgttttct acattggatt aaggttgttg aattgaaaac atagcaaggc gaggatgaga 497700 gtttcttccc tgtctaaatc actcagcccc attttaaaga aaaactctgt ttcgtggtca 497760 caaattctaa taccaacctg tttttgtttt ttttttcctc acaattgtgt gttattggcc 497820 ctgggtaaac cacatatgtc atacatgtgt gtgagaatgg cccagggcaa acccaccagt 497880 gccaccttgg gacaaggcaa attaggattt atatgatcaa tacttaggtc actattggta 497940 gccagcatgt tgcatttctt tttttttttt tttttttgag atggagtctc actctgtccc 498000 ccaagctaga gtgcagtggc gccatctcag ctcactgcaa gctcctcttc ccaggttcac 498060 accattctcc tccctcagcc tcccaagtac atgggactac aggagcccgc caccacgccc 498120 ggctaattgt atttttagta gagatggggt ttcactgtgt tagccaggat ggtctccatc 498180 tcctgacctc gtgatcctcc cactttggcc tcacaaagtg ctgggattac aggtgtgagc 498240 caccatgcct ggcctgtatc tcttattgtc agtggattta tatcaacatc ctcacagaga 498300 ctcctgagaa ggcagtttga ccaacattat tgcatttgtt gcaaagagaa ataaagccag 498360 aaataaaaaa tagcgaagag gatgttccca aacaaaatgc tcctctgtga aataatgtgg 498420 ctgatacgaa ctgcatgcag tatgatagca aaaatgtggc tgataggaac tgtgtggagt 498480 atgattgcaa taatgtggtt gataggagct gtgtggagtt tgattgcaat aatgtggctg 498540 ataagaactg ttaggagtat gattgcaata atgtggctga taggaacttt atgggatatg 498600 actgcaataa tgtggctgat aggaactgtg tgggtatgat tgcaataatg tggctgatag 498660 gaaccgtatg gggtatgatt gcaataatgt ggctgatagg aactctctag ggtatgattg 498720 caataatgtg gctaatagga actctctggg gtatgattgc aataatgtgg ctgatacaaa 498780 atgtatgggg tatgattgca ataatgtggc tgataggaac tctctggggt atgattgcaa 498840 taatgtggct gataggaacc gtatggggta tgattgcaat aatgtggctg ataggaactg 498900 tgtggggtac gattgcaata atgtggctga taggaactgt gtggagtatg attgcaataa 498960 tgtggctgat gggaactgtg tggagtatga ttgcaataat gtggctgatg ggaactgtgt 499020 ggagtatgat tgcaataatg tggctgatgg gaactgtgtg gagtatgatt gcgtgatgca 499080 cttgctttgt tgaaagtcca gcctgttgtc gaaatgctat ctagtgatgt ttttatcttt 499140 tttctctctc tcttactaaa acctccagag ccactgaaag ccaccatcag tcccaggaag 499200 gttaaaagca gcgtgggtag ccaagtttcc ttgtcctgca gcgtgacagg aactgaggac 499260 caggaactct cctggtaccg caatggtgaa atcctcaacc ctggaaaaaa tgtgaggatc 499320 acagggatca accacgaaaa ccttataatg gatcacatgg tcaaaagtga cgggggcgca 499380 taccagtgct ttgtgcgcaa ggacaagctg tccgctcaag actatgtgca ggtggtcctt 499440 gaaggtcagt gggcctcgtt tcagggtatg gctgaaaaag aacccaaacc cagagcactc 499500 agaaaagaag aagacagggt gaagcagtgc tgatcgctca gttctaggct ctctgtctca 499560 ccagctagta ctctacccta atttttcaag ctaaatcagg caaatgggag agaaagttct 499620 gacgaaaata aaattgtttc atattagaag taatgtaaag taacataaat gttgcccact 499680 tgtgcattag aagttatctg ccagggttta aatcttagaa gaaacttgac acttaacagt 499740 tttgttgatt attcatctct agaccagggt ctttcaagaa tgccttgctt ggggaatttt 499800 tttttttttt tttttgagat ggagtttcac acttgctgcc caggctggag tgcagtggca 499860 cagtctcagc tcatcacaac ctctgcctcc cgggttcaag caattctcct gcctcagcct 499920 cccgagtagc tgggattaca ggcatgcacc accacacctg gctaattttg tatttttagt 499980 agagatgggg tttctccatg ttggtcaggc tggtctccaa tttctgacca ggtgatctgc 500040 ccgcctcggc cccccaaagt gctgggatta caggcatctt gggaaacttt tttatgtgtt 500100 ataggatctt tggcagcatc tctggcccct ttccactaga tgtatgctag gagcaccttc 500160 ctccaagttg ttacaaccaa aaatgtctcc agacattgcc aggtgtttgc tgggtggggt 500220 gggggcaata gcctccagtg gagaagtaca acttcagatt gaaaatgcag agcaaaatgt 500280 cagtacagtg gttggtagaa tgaaaatatg gcatctgttt ggtgcagttg tccctagttc 500340 catccaaatg ttctcagatt taagtaaatg aaatttgtga ggaattattt tgtggtataa 500400 taacaggttt tggatatgtg atacgatttg ctttttttta actggttact gcatactaaa 500460 tcttaaagct tatcagtcag ccagagaaag aagctatcac aggcaacata tatttatcac 500520 tacctgattg aactagcttc tatctatgta tttgtgtgtc ttgttggaaa ttatgtccat 500580 atataattta aaattcatct gatatcaatt gattaaaata ataaaatgat tttgatatag 500640 cctaaaggga gtacaaagaa aacacactaa tatgtgaaag taagtttaaa tatatcttga 500700 ttataagacc atatttctgt cattcttttt taaccttagc taatttttta agaagtagca 500760 ggtttagcaa tgagattcct attttgattc aatcgtttca ttgcagacag tgagattttt 500820 aaagcagagg tgaaattagc tgaaggcatg gtattcatat taaatgcctg acactgtgtt 500880 ccgtataata attaagtgca gaaagtaatc aatttgtgca gaaccagttt gctaatgatg 500940 atgcactcta gtccttacat agtcactatt tttagattct ttgtagaaaa aggagaaatt 501000 acctgtctag gcccagttac cccggcaacc atttggtgca actaagaaaa cctaaagacc 501060 atattgatga tccataacga tgtcagaaga gttcaggtta tcagagtgac agcaagaaag 501120 atttcaaaga cactcaggtc tccctgggaa aataatgtct gctttcatct ccaaaagagc 501180 ctgtcacttg aactaaaaag ggggccgagg cgcaccgcca gcacactcgc agatttattt 501240 gtcgcatgtc agcttccatt caggacaaga agcttcactt ttttttttct ctcttctgag 501300 agatgacagt gctaatgtag caaagaaagc agaaatggaa ttacaaatac atatctagta 501360 cctgctttaa aagagtgtct ggctaatttc ctctggaaaa caaaaacact cccattattc 501420 tcactgaaat agcgatggat taaagtaaaa ttataaaaat ttgcaatact gtgaactagg 501480 actgaggata gatacaatgg agaatctgag aatatttcct atgaggctat aaaatggaat 501540 ttaataatta taagttcagg ataaaaccat aatacctgaa aaatggaatg attttaaaaa 501600 agaataataa aagtttccag ttctgggaat ggtaaaatag catatatcag cctaactccc 501660 aagatgataa aaacaagaaa ctttgggaaa agcaaaagta tatatagaca tttgagagac 501720 accaaaatca agttggggag tgtcctcttc cactgaggac acatctgaac tccaaaaatg 501780 gggagtgaga atacaaatgt gcaataaaaa tgagacatac aaaaaacagg actctgcacc 501840 caaaggacaa aagacaaagc aaacgataga aacaaatcat gagaggaccc agatgttaga 501900 actggcaaac aaggacttta cagatgctat ttaaaatatg ttcaataact tacaggaaaa 501960 tatggactga aagagtgaac gtatgggaaa gaccaacaga gaaattgaaa ctgtagaaaa 502020 cagtctgtag aaatgaaaaa aaatcaccat atttgtttaa tacaagatta gagaaggaag 502080 aagaaagtat cagtgaactt gaagataaat cttagaaaat tattcaatct gaagcatgga 502140 gagaaagaag actgcaaaga aaatgattag agcttcagtg acaagtagga catcatcaga 502200 taacgtgaca cacacatatg actagaggcc cagaaaaata ggagatacgg aatgcagaag 502260 aaaaaagtat tcagagataa tgaccttagt tttatcgact ttggtataaa agtaaggttg 502320 cagatctaag aaactcagca aactccaaaa ataaacacaa agaaaattct atgtcagtac 502380 atcagagtta agctgctgaa aaccgaagat aaagagaaaa acttaaaaat ctgagggagg 502440 aaaaatatta cataatgagg acatcaataa caaatggtag atgattcatc ggatattttg 502500 gaggacagga gacaatggag caacatcttt aaaatgttga aaagaaaacg aaaaacaaag 502560 acacagccct gccaacgcag acttctgtag caaaaaaccc aacaacaaca ggctttaaaa 502620 attaaggaaa aataaagata ttttcagtaa taaagaggtg aaagaatata atgtcagcag 502680 ccctgcacat taataaatga taaatgaagt catgccggat atagagaatg gacatttata 502740 tctacaggat atagataaca tggaacagaa atggaacata aaatggagac atatctataa 502800 gaacaaatac catgagaaat ggtaaatata ttagtaaata tttagcaaaa ttgtgttttc 502860 ttttttaatt tctttaaaca attgatgatt ataacattat aaaattacca cacttggcca 502920 tgtgctgtcg ctcacgcctg taatcccagc attttaggaa gccgagacag gcggctcact 502980 cgaggtcagg agtttgagac cagcctggcc aacatggcaa aatcctgtct ctgctaaaaa 503040 tacaaaaact agccaggtgt ggtggcatgt gcctgtaatc ccagctacag gcagaggcag 503100 gagaacagct tgaacccagg aggtggaggt tgcagtgagc cgagatcctg ctactgcact 503160 ccagcctggg tgacagagtg agactccatc tctaaaaata aaataaaata aaataaataa 503220 aatgaaataa aataataaaa taaaaaataa aataaaatga aataaaataa taataaataa 503280 aataaagtaa aataaaataa cactttatta tagagtaaat ataatagatg taataacaca 503340 aagggcagaa ttatttgttg cagggttctt acatttcaca taaagtactg caatcttaac 503400 ttttagcaga gataatttaa aacatataca cacacattga tatacatata gattgtgtgt 503460 gtgtgtgtgt aaatcaattg gagcttatct tataatgcaa gattggaaga acattaaaaa 503520 tctaatccgt gtaagtcact atgttaatag aataagggag caaatccaat tgattatctc 503580 aatatataca gaaaaaatca tttgatgaaa cttgcatcca ttcagcataa agaatttcta 503640 gcaaactgag actctagaga gcttccttga cctaatgagt ggcatcctga acaatctaca 503700 gctaaaatca tacttcctgg ttaaacacta aatgtttttc atttaagatt gagaccaaat 503760 caaggatgcc cacatccacc acttccattc aacattatac tagcagccct agttaggctt 503820 gagtagaaat aaaatggatg gagtttggaa aggaaaaatt tcagctgtct taattacagg 503880 cattgttgtt tacaaagaat atgccaagaa aacaataaag caatttctaa aagagagttt 503940 aaaaagtcat tggatataag aatgatacac aaaatgcaat tttatttcta tatactcaga 504000 acaaacaatt ggaaactaat attttgaaac tttcatttac aataacataa aacataagat 504060 aggaatatat tttaaacaaa cgtgaaagat ttcaacatac aaaaatacaa aactctgcta 504120 atataaaatt gaaataacct aaaaaattga aaagatatac catattcaag gattagaaaa 504180 ctaaatattc ctaagttaac aattctctct aaaacgatta atgtgatttc aagcaaaact 504240 gaggcatggt ggcttgtgcc tgtaatccta gccctttggg aggctgaggc ccttagccca 504300 ggagtttgag gccagcctgg gaaacatggc aaaactttgt ctctacaaaa aaaaaaaaaa 504360 aaaaaaaagg cgtggtgtgc acctgcagtc ccagctactt gggagattgt gccacaccaa 504420 ggacaacaga gggagagaga cactgtctca aaaaaaaaaa aaaaatatat atatatatat 504480 atatatacac acacacacac acatatacac atactatatg taccttttca acaaattaac 504540 actgaaacaa ctcaataaat gtatggcaaa aaaatgagta ttaatcccta catcacactt 504600 catatccaca caaaattaag ttgctatccg tatagaattg aatataaagt ataaagcaac 504660 acagtctcca aaagaaaaca gaataattct tcatgatttg cgaataggtg acgatttctt 504720 aggacacaga aagcattaaa tgtcaacaca aatacattat taagaaaaga aaaaggcaac 504780 cacagactgg gataaaatat tttatacaca cacaaatata tgtgtcatat atatgttgac 504840 agatattata tataatctct ataggaatct tacaaatgta tcagatcatt ataagatatc 504900 tgacatagat actatatata tatttccttg tatttcaatt gttgtattcc acaacaaatc 504960 aaaaacaaaa aggcaaacag tctaatataa caatggccaa agatttgagc agacacccac 505020 taaaggaaac acacggatgg ccaataggca cataaaacac gtgccttcca cggtatttct 505080 gggaaaaata tacaacctgc gtttagtcat gaggaaatat gagacaaacc caatttcagc 505140 aactgactac aaaattactc ttcaaaaatg taaaagtcaa gaaacacaaa agaggctgaa 505200 gaatgttcca gatgaaaaga ggctgaaatg acatgaaaca taaataatgg gtgatacgga 505260 ctgctctgga aaaaaaacag tgacgaggga tattagcggt caatggacag aattttgctg 505320 tggacagtga gttagataat agtactgttc caaagttaca tcttctaatt atattctaag 505380 tgtactctga ttatgatgat atatatgcac atataaagcg tgcatactct attattatgt 505440 ttcttctaag ctcaagcaca ggcaaaacca gcacatccta agaggaatca gagcagtgat 505500 ctctgttgga tgtggattta ttgaaaggag cacttaagga attttggtaa tggaaatgtt 505560 ttatatcttg atcgtttttg tggttactct ggtgtgtata tatttagcaa aactaagctg 505620 tacacttaag atctgtatat ttcactgtat gtaaaattta cctacaaaaa gagaagtata 505680 actgaagaac atttttctaa acacttgagt tttcagagct taatgtaaaa accagtgaaa 505740 agaaatctac agctaaacac attttacaaa aaccatggaa ttataaagga cacgtgaaat 505800 aactccagta ctcctaagta ttaatgactg atcatggaca atgaatagca atcatgatga 505860 catctaactt ctctgtaaaa ttaaacacag gatgtgatga ggcaacgtct gcagtgcgtt 505920 aaagacaaaa gcatcaattt ttcattttaa tattttaaag ttgtcttttt catctctgat 505980 agtaagagac aaaatgctta caacccaagg acactgcaat atgctactta tgagcatagc 506040 ctggaggaaa caaactccag ggacttctcc agccacctga aacatgagct ggaatgaaga 506100 agtgagattc aggaatttgg aaaggagtag ggggtggagg gaagagctgc agcacagccc 506160 catcaccatg aagaccctac ataactggcc tccctgacca agaactaggc cccaaggttc 506220 tgggggaatg agtggcactt tcctcaaagg tgtctggtac tattaaccat taactgtcac 506280 ctttccctga tggaattgca agctatccta attttgcttg cctcctttct ttttgtttat 506340 aatactttcc aattttcaac aaaaaagata ttcaacaatg gagattcatt acttttataa 506400 taaaatcaaa aactaaaaaa aatctactca ttcttatctt tcattatggg acaacccttt 506460 aattgaacac aaaaattctt ttaaaaaaca aaagatgtcc cctccagcaa ggtctcttac 506520 cagactcaga aatcctgtgg catgtgattg caattatgtc aaaatgaccc acttatgcct 506580 agaaaaaatg tgtcacagtg ttgatttgta tgcctgaggc tggctgacct attggtaact 506640 tttcttctga ttttcataca tttcctttaa tatgcatgta tttcttttta taaatggaaa 506700 aacatatata aaagaaacat gcatttgtaa ctattactat ataagagaaa aaaccatatg 506760 gatgatagaa aaataatgga atatgaaaat ttgatctatg taaacatact gaaaatttct 506820 atggagactt ctctaagatt aagatcctag tttgcctgcg atagttctgg gtcatgcctg 506880 ttctcttggc ataattatta gtcctttctg tttcagcctc aaaagtgtcc caggttggat 506940 gttaaattat atggccagcc tacttaagat acttttagag agatttaaaa catgcttaag 507000 taccctactt aagatatctt tagaggtttt taatacacgg catttaatac aaactttatt 507060 tagcttctac ccattctcag agacttcatg gaagtttgca tgcaattact atttgtaatt 507120 aaagttatta aaagaggatt tcttatgaga aaatgatgaa gatgaggtca tcaatctctc 507180 agtagtttcc tttattcctg taaagaattc cctagtgaga aaaccccaaa taacttgagg 507240 aagtattagg ttggtgcaaa agtaattgct gtttttgcca ttactttttg caatcacttt 507300 tgcaccaacc taacagataa agtgactgtt tgtgggagtg agcgggtgtg gattttccgt 507360 ctgtttataa ctttgtgtga ggaaacacca gttttaaatt aaggacttct taggagctgt 507420 cattgtttaa cctgaacatc tgagttgtat taccattcct cttaagtcaa tcaggaaata 507480 tagaaacagt tgatgaaagc ttgctaacac tgtgcttacc tgttttgaaa acagtgaact 507540 cttgttctga ttaacgtttt gctttatcag gaaaaccaga cctttttggt aatgtttaac 507600 aactacgaca tttaccccct agacatgaaa gacatatact tggaagttgt ttaattattt 507660 gtatgtgcca ctttcttcca taatttgttt tcctgcagat ggaactccca aaattatttc 507720 tgcctttagt gaaaaggtgg tgagtccagc agagccggtt tcccttatgt gcaacgtgaa 507780 gggaacacct ttgcccacga tcacgtggac cctggacgat gacccgattc tcaagggtgg 507840 cagtcaccgc atcagccaga tgatcacgtc ggaggggaac gtggtcagct acctgaacat 507900 ctccagctcc caggtccggg acgggggagt ctaccgctgc actgccaaca actcggcggg 507960 agtcgtcctg taccaggctc gaataaacgt aagaggtgct tgtcaaatca gctcctcaaa 508020 aaaacacaca taactcatta tagtggagaa gaagatttct gcatgcaccg agctgggtct 508080 tggaatgcca gagcggatta actgttgctt cccatttcct accctctcct tcctactcag 508140 gaatggcact gactgggtta atgttggaaa tggcattttg gtttctgtag tcagcttgtt 508200 cttttttact ctagatctgt tcacctgatg tttcctttcc tggtttatgc tctgcatgcc 508260 ctttcccttc tccttctctt cggttcttcc acattcatgg taaaccttca tgtacatggt 508320 attaaactta cattcatgct gcaacgtgat gtaacctcca ttgtcgtcct agattttaca 508380 gagagagtta aacaattgat caattgctgc cagtgtgttc accaaaagtg cgtgattgtc 508440 cagtatagac tagttacttt ctattaatta aattgccttt tatcttgtaa tttttaattc 508500 aaaacatttt catagaagta gcagataaag tgtttcacag ttatacattt gaatttaaga 508560 aaaggaaaga aaaacctttg ttgtagaaaa tgccacatgc aaaaatattt gtttaactga 508620 aaaagatgtg cttacatgaa tataatctac atttttaact caaggaaaag tgtacccatt 508680 tccctacatg agatgtaccc ttaaattatt ttcaagagtt tctttgtgtc tctccagggc 508740 ctgcaagcat tcgaccaatg aaaaacatca cagcaatagc aggacgggac acatacattc 508800 actgtcgtgt gattggctat ccgtattact ccattaaatg gtacaagaac tctaacctgc 508860 ttcctttcaa ccaccgccaa gtggcatttg agaacaatgg aactcttaaa ctttcagatg 508920 tgcaaaagga agtggacgag ggggagtaca cgtgcaacgt gttggttcaa ccacaactct 508980 ccaccagcca gagcgtccac gtgaccgtga aaggtaagcc ctgttctcct ggttcccaca 509040 caactcattc catagcccga ctacttccca gaccaatgat ttgaagtcgg gtaatccaag 509100 atctgcttat ttagagcagg ataattgtac aggctgaaga atgacaggga acatgagatg 509160 tcctctttac tactgactga atcttcacag gaactttagt tgatctgatt ttctctccag 509220 gtggaatttt ggcttggttt tccagagggc atgtgttgtt aacaatacaa cagaaaaaaa 509280 aggagcacat cattagcttc attatctagt catctctcag ataattttta aataaataac 509340 cttcttttcc taaaacctcc taaaagcaag gtctcttaga acttcactgg aagggatttt 509400 ctgtattgga tgaggatttc aaacaaacgt cttatcttct gtagatgagc aggtcaaagc 509460 aacaacatag aaattatatg tttaaaggat gccacagaac gttttcctca ttaaattatt 509520 ctttgcatca tgacatggac tgtcatggaa tctacctgtc aggatgatct ttagagatcc 509580 tgcaatttga attgactaca atctccttac cagaaaaaaa caataaggtg atcagactca 509640 tccaaggata cgcagacttt tagtggcaga gcctcagaaa gactcatttc ttctattcta 509700 caagtcagtt tcctgagctg aatatgaaat aaaattgttt taattatgta aggaatctac 509760 ctgaggtggg tcctaggaat agaactaata tgttataaaa ctatttccga aacctgtggg 509820 tgttgcttct agccacattg agctgcctgt ctgaggtgtc caagttctct ctccaggaac 509880 caataagtgg cttttagttg cccttgttac aaagttgcat aggtttcctg tggtcttccc 509940 caagcttctt ttcccaccaa ccctgtgagt tttacttttg tgagaacgca tacagacaca 510000 cacacatgga aataataata tgtgtatact attattacgg ggcatatata ttgcattaca 510060 ttatatatta tagaatatgt attgtgcatt gtatattaga tatgcctgca cataattata 510120 aatcggtttt taataaccat atgtcttgag aatttcctca aatcactaga tattcttggt 510180 aaaccaggct gcataaaggt tcatttggtg gttgtgttta tttatttaat cctcatttac 510240 agaacatctg cttcatgcca ggcactactc tagacactga ggaatacaac aatgaaaaag 510300 gtctgcaagg tcctttcctt cattgactct cttctcagtc aggagagaca aacaataaac 510360 aaataaaaca agtgaataaa ccagaaaaca cctaatggta ctccatacta tgcagagaat 510420 taaaacatgg cagtatctta atggttcatt gcaatagtca gatgccatat caacacattt 510480 tctgtactct gtcatcttaa aattcattgg tctatcatac ccttggaagg aatgttttac 510540 ccacacatga ttttgtaaca taaaaagttg atcatttgga aatgattggt tcactgtgtt 510600 acacagatct tccaaatgtt gatacaattt gttatacaat atcaaaatat cacaactact 510660 aacattacca tgatctcatc agaaagtctt caagtaaact gtcaagttca tgctgatgga 510720 tgcaagtttt ctaaaattct attctttctt gaaagattca attttattat ttataataaa 510780 caccatcaat tgtaattgta ggagtgatgg gctcatttat ctgtaagaaa ttgtttgaca 510840 aatagaaaag accgcataac catcgttttt aggtagccat tcttttaaga aagaaatgga 510900 attccatgaa gaaaagcagc tggtcgaatt tgcaactcaa gcaagcacag acatactctg 510960 cttgaaaata gccgtgctgc tcaggaggtg gaggaaacac tgtgccttct tcccatttta 511020 ttacacagga catagaacat taaaaataac gtgagcttta gggtaaagat gtaataaaac 511080 tgttatgttt cctgcttcgt caagtgtctg taagtgaatc tggcattttt aaaaaaccaa 511140 ctcacagtat gcatcggtaa acagtacaat gaatagtcat cctgttagtg tccctgctgg 511200 gattcatggt aacgcccagc agtctcaccc accatggctt ttgctccaac agtgcaaatg 511260 tcaacaccat gagaaaggca aacagcacct cagcattgtc atgaaaacga ttttcttctt 511320 acagatcacc taaaattgtc tcagggatcc ctacaggtct gtgagctaca ttttgaaaac 511380 atctaataca gtgctaaaat tttagtttat ttttaatgtt tgaccattac aaatgaggca 511440 tcaaatgaac ttctttatgc attggccttt gtctgatttt aagattattt ctttcgagaa 511500 aaatttccag aagtatgacc attggataaa taggtataat actttaatgt aatttttagg 511560 agacatagat ttaaacgaaa gccctttgaa tcattaacat ttattcttta aatttgccag 511620 atcagtataa atgaatgtat tcatcttaat ccttttgaag tgacagaaac caactcaaac 511680 tagcttatgg ccaaaagaat aatttattgt ctcttataaa caatatattt atgattttag 511740 gaaataattc tattgaataa ttttttcttc aggagcttct tttcttctga atacttatca 511800 tatagtataa aacttgtcag ctcctttgca agtacttgca aacaaaagaa ggaaaatatt 511860 attttatgtg gtattttatt gcctggagag aaatggcagt tgttgggatt tggggcttgc 511920 caaatttttc agaatagtcg ggaaaagctg cctggaaaaa gtgagatttt gagcaaagat 511980 gtgaaggggt tcaagacagc tcatggatac ctggggaagg gacatcctag gtaaagggaa 512040 gagatacaac cacggtgtct agagtttgcc tggcaagctt gaggaataac agagaggctg 512100 gtgtggtggg agccaagtga acaagaaaac actaaaaggc cctgagtcag aaggagcaga 512160 accttttcac gggggactta ctagatcagg acttcggttt tcaggacgtg gggttttctg 512220 ctgagtgaga tgggggcttt attggatgac tttaaacaga aaagtcacat ggccagacta 512280 aggttttaaa aggatgcttt tagccaggca aggtgggacg agcccgtagt cccagatact 512340 ccagaggctg agacaggaga atacttccag tctagtagtt tgaggttgtg gttgtggtgc 512400 actatatttg cacctgtgaa tagacactgc actccagcct gggcaacata gtgagacccc 512460 atctctaaaa agaagaagga cgcatctgat tcctgtgctg agaatggtct attcggggaa 512520 agggggcaag tagaatgacc tgttggaaag tgaatccagg tgagagatga tggtggcttg 512580 gaccaggggg agagcagagg aggttggggg tagaagacag actccggatc tatttcgaag 512640 gtctattcag tcggttttcc tagtggttgg atacaggtgt gaggaaaata aagacatcaa 512700 ggatcaggtc aggcttctgg cctgaatatc aggaagaatg gcattgcttt ctactgagtc 512760 agcagaagat gcagtggagc cgtttgagga aggcgattag gagtctagtt atcgatgtgt 512820 tgaggttgaa atacacacta aacaaagaag tggatgctgt cagtaggaaa ttagatatgg 512880 gagagtagag ttcaggaatc caggctgcag atctggtgac atcagtgaat agatgatgtt 512940 caacaccaag gcctgaacag gaccctcagg ggactttgtg cactacaccg cagattttaa 513000 cttcatatgt acaggcttcc ccagccccca gtcaggctca cattagaacc cttcaccaaa 513060 tatctgaaaa taaagtctga caaaaattca aacaaggact gtttgaaatg taagtttacc 513120 tatttttaga tttcccagat tggcacagat ccatgtattg actatgaccc cattggttgc 513180 aaggtgcgag aacccaaatt acctttgctt aagcagccag gtgcagaggc tcactgctgt 513240 aatcccagct acttgggagg cctaggtgtg atgtggtacg cacctgtagc tccagctact 513300 ccggagactc aggcagaaga atggcttgag gccaggagtg caagactgtg gtgaactact 513360 tccaaaacac agtaacagtt ttacaccatt cgcaatctta gcctttactc agaacttaga 513420 agggtcttaa ataaaatgac ttctgaacat ttaagtttac attttaaaat attttaacct 513480 cagcactttg ggagaccgag gcaggaggat cacttgaggc caggagtttg agatcagcct 513540 ggccaacgtg gcaaaacctg gtctctacta aaaatacaaa aattagccag gcatggtggc 513600 acacacctgt aatcctagat actcaggtgg ctgaggaggg aggatggctt gaacccagga 513660 ggcggagttt gcagtgagcc aagatagcac cactgcactc catcctgggt gacagggaag 513720 actctgtctc aatcaatcaa tcgatcgatc agtaaaatgt ttttaaatga aatattaata 513780 tataaagtaa attatactcc aatggtcagg attgtagttt atcaaggctt tttaaaaatt 513840 aacctttact attttcagtt accaagtatt aggggaggga gataagaaat tagctaaatt 513900 ttaggaaaag acttagaatt ttggctttcc ctgtggatta ggattgaaag agactttctt 513960 attttgttca tgtaaatgca gctccactac ttttcctggg agaccacaca gtgaatattt 514020 cagccagcta attttggaag agcaaacctg aagccttaaa aattggcttc cttgggaagt 514080 ggaagtggcc cacttgatcc cggcaataat gctgctaaca gggaaaccaa attattgtta 514140 tcttgtcccc aggaggttcg ttttaaatac tggatatagc ggaaagtgtg tgcatatgtg 514200 tttagatgat atttggaaac aatactattt tttcatcatg tcttttcctg gcaatagtca 514260 taaccctttg cttattttgg agcatatgcc tgcaattttt tttatttcaa agattgatat 514320 aaataatatg cttattattg atggtggttg aagcttaagc agttctgaaa tatatgtaac 514380 tatccagaag tgcaagtttg ctgccttcaa acatataggc agaagtaaaa gtcaaagtcc 514440 cttctttcac ttcatttcaa cttaacaagc agttttatat ttaacacatt ttcaagcttt 514500 gtctttccca ttttaggtgc cacattgaac ttgaacggtg cttaattgcg tgttctaatt 514560 gctggggatc aacactgcca ggaaagttaa ttggctgctg gataaaaatg tcacctttta 514620 tttatattta tataaaactt tatagtttac aaaacacttt catctgtgtc accttaatta 514680 atacagtgac tctgtaacgt agataaagca taatcaggga aagaatagaa gagagatgag 514740 gctgcgcaca gtcacccagt aatacattca agactcaaac gcagatgttt tgattccaac 514800 acaacccgtg gtgactctca gaagaataat tcgtattgca gcgggaagcc agggtaggag 514860 tggggagaaa tgaatacaaa gaacccagga ataaagctat ttaaaaagtc aagacagaca 514920 acatgttaaa atgtagggca aaagatattg agggactaat ttaagagaga tagcatttgt 514980 taaattggag agaggaaaag gagagaatgg atttggtgaa agagggcagg tcagaacaag 515040 aaaggactcc agaagctctt gcttgggaga tggagaggct gagaggagcg atgtggcacc 515100 tgagtgtctt ggcgaaagcc tttggatggc ggggttggtc ttaagtgcct gtggatcacc 515160 attctggctt cagaccatgg ggatttaaaa aaatagacag gaaagcaaac taaaattcat 515220 agagaagggt agttaaaatc acaggtaaat aaatgtctaa gaagcaccaa gctttcagag 515280 tcatatttta tgaggatttt taaaagtgaa tgtttgccaa tagtgagatg aaatggccat 515340 gctaggaatg cagagaacaa cagaaacatt cgcttttaca tatttcattc catttctata 515400 tttgtggcga tttctcattt taatgtacca gcattttttt accatgtcct ccttcaaatt 515460 gaagggagaa ttagatgtca ctgccagggt tttcagctct tgtgttggtg gtactttgtg 515520 tactgtagcc caacagggac actgttctgc acattttgac gttaaaatcc tgcttccctg 515580 cagctttttg tcctgtgctg tgtctcgtct gtcaccgtaa tgtcttgctg tattgctgtt 515640 ggtgcaagtg gggaaatgaa tgctgagtta aaaataatgc tgtgagtgtg tctgctcgcc 515700 ttccactcga ggtgagcggc cggggatgcc gtcttctaat gacatcattc ttcaaaggct 515760 gggaacaaat gtcatctcgc ctaggtggag ggacagcttt gtgcacagaa acagccttgg 515820 cagtttcccc actcctgctt tcagacattt gctcattagc tgttccaacc ttggcactat 515880 cagcttccac tgaattccaa acccaactct gttggcaagg aaaggtcttt cattcttaat 515940 ctgtcacttt cttccacttt ctcctactat ctctctagat actggagtta cttgcaatat 516000 tgtttatgga aaggacagca ttttgagttt atttttccat tttagttcct cattaaagtg 516060 gagcaatggt taacttaagc tccagtttgc tggggtcttt tgtgtgtggc catacactgc 516120 agtcatccac atattttcat atttattttt caacaacgac ttgggaattg cagagcttct 516180 attatgaata atacacgaga aatatagacc tggggaaaaa tagaatggta acgtattaaa 516240 tgtataatcc ttttatgtta atttattatt taaaatgaga atttatactc tctttttaat 516300 ttaataccct aatgtgagaa aagaaagcta atgaagtggg aactttcact gtcctccctt 516360 tttaaatgac gcaagaaagc actcatgctt caatatactt aaatggatgc attggctcag 516420 ctaccctggg ggtttatgct ctcaagtgtc tgcagaagag aggtaggata tcaaaattga 516480 gtgcaggact cagcttctat gggttccttc agacaggttt gtcctggagg tggaatgact 516540 taaaattcct ctattctaga aatcgaagca gacacctttc tttaaaatat ggcattttat 516600 taagtgtttt ataagcgata tctcaaatta ctttacccta attggaggga aaaaaagact 516660 atgtgtaaga ttggtttcat tatgaaagaa tgctatatat atatatatgt ataatatata 516720 tttattatat aatacatata taaatatatg cataatttat tatatataaa tatatgcata 516780 taatataata aatatataat ttattatata taaatatatg catataatat aataaatata 516840 ttttgatata tataaatata tgcataaata tatgttatgt attgcatata ttacattaca 516900 tattgatttt aaatgtatat acatgatttt ttacattgta aataaaataa tatgtattta 516960 cattttaaat aaagtgatac gtatttcctg tgtatagtat aatgttttga aatatatatc 517020 cattgtggaa tgactaaatc tgatcaaata acatataggt tgtctcacat agttatcatg 517080 tttgtggtaa gaacacttta cattcactgt aaacattttt caagaataca ataaattatt 517140 agctacagtc accatgttgt acaatagatc tcttggactt ttcctcctga aattttgtgt 517200 cctttgacac acacctcccc agtaactcca gcccttggga accaccattc tcctttctac 517260 ttctataaga tcaacctttt tagattgcat atatgagtta gatgatgtgg tatttgcctt 517320 tatgtgcctg gcttatttca cttaatataa tgttctccag gttcatccat attgtcacaa 517380 aggactacag ctcactcttt cttaaggttg aatagtctta aggctgaagg tccttatttt 517440 attttttatt tttattattt atttatttat ttatttattt atttatttat ttatttattt 517500 agagacggag tctcactctg tggccaggct ggagtgcagt ggcgcgatct cggctcactg 517560 catcctctgc ctcctgggtt caagtgattc tcctgcctca gcctcccaag tagctgggac 517620 tacaggcgtg caccactatg cccagctaat ttttgtattt ttagtggaga caagccttcg 517680 ccatattgac caggatggtc tcaatctctt gacctcgtga tctgcctgcc tcggcctccc 517740 aaagtgcagg gattacagtt gttttatttt aacttgtccc tttttttggc aaccattgtg 517800 tatgtatacc atatattttt taatccattc atctgctggt gaccatttag ccacttgaat 517860 ccatatcttg gctattgtaa acaatgccac aatgaacatg gaagtgtaga tatctcttca 517920 acacactgat ttcatatcct tttcatgtat acccagtaat gggattgcta gaaaatatgg 517980 tggttctatt tttaatgttt tgaggaacct ccatactatt ttctatagtg agtataataa 518040 cttgcattcc tatcaataca gtacaaagct tctcttttct ccacatgttc accgatgctt 518100 gtttttttca tgttttttat aatagccatt ctaacatgtg tgagatgata acctcatttt 518160 ggttttagtt tgcatttccc tgataattag cgatgttgag cattttttat atacctgtta 518220 gccatgtatg tcttcttttg agaaatgttt attcaggttc attgcccatt ttttaatatt 518280 cattcaattt gcctattttc aaatcaggtt gttttcttgc tattgcattg tttgaatcct 518340 ttatatattt tggatagtaa ccttttatca gatgtacggt ttgcaaatat attctttcct 518400 tctatatata ggttgtcact tcattcactc tggtgattga ttcctttgct gtgcagaagt 518460 ttttttagtt tgatgtaatc ccattgttct atttttgcgt ttgttgtcca tgcttttggg 518520 gtaataacca aaagtcactg cccagagcaa tgttaggaga tttttcccta tgttttctcc 518580 tagtagtgtc atagtttagg cccttccatt taagtcttaa atccagtttg agtttaattg 518640 tgtatatggc attagagaca tcataaatta aagttaatga tctaattcca tttttctgct 518700 tgtgggtatc tagtttcccc aacaccattt actgaaaaga ccccattgtg tgctcttggc 518760 tcctttgtta aaaatcagtt tgctgtaaat gtgtggattt accattctgg tccattggtc 518820 tatgatttta tggaagtaca atgctgtttg gttattatag ctcagtagta tattttgaag 518880 tcatgtggtg tgatgcctct agctttgttc tttttcctca agattgtttt ggctattctg 518940 gctctttttt ggttatattg gaattttagg attttttttt ctatttctgt gaaaaatgtc 519000 attggtattt tggtagaaag tacattgact ctgtaggtca cttcaggtaa gatgggcatt 519060 ttaacaacat gaattcttct catccatgaa cacaagttat gtttccattt atttctgtct 519120 ttctcaactt ctttcaccaa tgttttatac ttatcactgt agagatcttt cacctccttg 519180 gttaatttat tcataagtat tttagttttt gtagctattg taaatgagat tgttttcttt 519240 aatttttttc agatagttca ctattagtgt atacaaacac tactgatttt tgccttgtag 519300 ctttatcata tgattatttc aataggtgta gaaaaatact tgacaaaatt taacatcctt 519360 tcatgataaa tattctcaac aatttagata cagaaggaat gttcctcaac ataataaagg 519420 ccatacatga caaacctaca gctaacattg tactcgagac aagttggaag cttttcctta 519480 agattctgaa caaaaaaaaa aagatgcaca ctcttgccac ttccattcaa catgtcactg 519540 gaagtctcag ccaaagcaat taggcaagag aaagaaatac aaggcattca gataattcaa 519600 attggaaagg aagaaattaa cttgtttgca aatgacatga ccatatatat agaaaaccct 519660 aagacactac caaaaaggat tagaagtaat aaaccaattc agtaaagttg caggatacaa 519720 aatcaacata taagaataca attcttttat ttagttaaaa ttgcaagata aattatgttt 519780 tataatactt gttgcacttg ctgaacatgg gaaacttaga gaaggagaga attatgtaga 519840 gataagaaag ggaaaagaat gccaagcaaa ttactaacac ttttgctgtc taattcataa 519900 ttaatctgca aatacacaca cgtttgtgca cacaccacag ggaaaaactc tttggcagtg 519960 ctaaaaataa tgccgtgata atgacatttt aagtcagaaa taacaactct caattattca 520020 gaaccatgcg gtaggatctt ttatatgcat tgactcaaaa cacatgtaaa ttgtttaaat 520080 atataaattc aataaaattg tgtacttcat acacctatat aacatttata tgcattatat 520140 tttaaatata aagatatata aatataaaac acaaatataa atatacatat agttatatat 520200 gtatattata tataagtaca tatatatgtg gttacagata tatagatgca tgatacaatt 520260 atagactctt agaatcttag ggctataaat cagcttgaag ttcatctaga ccagcctccc 520320 atgtgatatt caacatgccc ctggactgta ccccacattt ttctagactc ttcctgcacg 520380 atctgtgcag tggttcacta agctctcagc cctttctgtt tctacatggc tgtgattgtc 520440 agacagttct tcctctgtct gacatacata caaatagaga tacatacaaa tatgccttct 520500 ctagctcttc tcttctttct ggttcgaata ttccctctag agcaacacta aatagttccc 520560 cgtttctcca cataaagctc ccagtcgtgc aaaagactaa gctttgtctt cctggctaac 520620 catctctagc gtccccattt gtttaaatac tttgtatgca acgaagttca gcagctcctt 520680 tcctttgaag gacacactga tgtgtctatt ttgtctcaat gaaacatagc cctctgggca 520740 ttttctaatg aataaaagag gggaatgaga gtgccacctc tgtcctgaag acaagaacgc 520800 ctagttgcag cccatgtccc actgttgagc catggtttgg gactcatgaa caaaaatccc 520860 aatggtgaat tttgtttttg ttttgtcaac ttttggctga caccacacca ttatcatctg 520920 tccatgcaag atccttattt tgttttattt taacttgtcc cccctttttt caaccatcca 520980 ccaattctgg tatcgtttgt ccctgtctca taggcacaga cttatgtgta cttaatatat 521040 ttattttaaa ttaattttct ggcatcctta tttagacatg catgtaaata tatacaataa 521100 cagcacaaaa gtgaatgctt agtttgcccc ccacccagcc ctttgactct gtacaaatac 521160 taccatgggt atcttataaa tgtgtccatg tgtagtatta atattactag agggccagta 521220 gtagaattgt taggtcatag aatttaactt cactaataat tgcatagcca ctctccaaaa 521280 ttcctatacc agtttacttt accaccagct atgcattaga ggtcccagtt ccccgcatcc 521340 tggtacctgt gtttctattt gtgacaaagc tgattgatgt aaaggagctc tttgttttaa 521400 tttgttttct tttcattact attgtgcttg aatgtctttt tatactctca ggagatgtct 521460 gaggatttca tctatgcatt gctttgtgca tttgctatca ctcctgctac ttcttcctgc 521520 tttgctgtag ttctttagta taaatatgaa tctcttatta cttagaaatg attgtgaata 521580 tcttttccaa ggctgtcttt tctctcttaa ctttgccttt gtcttcattt ggaccttgtt 521640 taagaaattt atgagctcat gaagatgcat tcctattttt ttctgtattt gttctatgtc 521700 tctatttttg ctgtttgcat ttaggccttc aacccacact gagcttcaca gatatagtaa 521760 agctggggtc caatatattt tctatctata tcgagtcagt tatcccaata tttattaaat 521820 gacccatgtt ttcttctcct ctccatctac caagatacca tgatggtgct gtcagaggca 521880 gtcttagttc tgtgaaatat attgactacc tttttatacc cttgtctcac tgtaacatat 521940 ttcagcactt tacttaaaaa aaagcctctt caagtcagtt attattaacc aagcttctaa 522000 agagctatga ccttttctaa gccaacgtca tgaaaaatac ttctcaagca aataatctat 522060 tactaacaat ccttgtaaaa aaactaattg gaaaaataag ccaagtttta aaatgaatac 522120 cagtgatttt atgaatcttg tttacttttg ttattaagcc tggttgtcgt cacctctggt 522180 tggggtcaca tggctttgct tccatcagaa gtccatataa acaaaaataa aataattgta 522240 cctcatctag atgacacttt tctctaacta aataagtaaa acatgagata tgtttcattt 522300 tcttgatgcc ttgatgattc aaatggcttt tcttttcata ttaaaaatgc agaaaagtaa 522360 ctcagtttta ttacagtctt ctgtatgaag gtattattgc tctcaaccag gggaaacata 522420 acctgtcatc ctgctcagac catggtgact ctaattgttt acatatagat attatcataa 522480 gtttttaagt tcttggtcgt tttaatcttt taaagaaact atttcaacat aatatgatta 522540 tggctttaca atacactcca taaaaataac tttcaagaga tgtttcatat gattgaagac 522600 tcaaatggcc ccaagaaatt atccagttct ttccaccaca ttccccttta ggcatctggt 522660 tgacaatatt gcagggcatc catttttttt ggaagtgcat tggaaggaga cactgccatg 522720 cttctcagag tttgttttac tcttttacgc ccccaaattt caagtagttt attttttccc 522780 tttattgtat ccaacttgca tcttttgtgt ttctctttat tataattcta ctttatgcct 522840 tgggatatct ttttcttgtt cctaaaacat tttaattatt tttttcctcc catggactta 522900 cttgataatt ttaaacaatt tttgggaaaa aagttatttg ccttcctttt atttcctttt 522960 ctctctctct cttttttttt tctttttttt tttttttttt tttttttttt gagacagagt 523020 ttcactcttg ttgcccaggc tggagtgtaa tggcacaata tcggctcact gcaatctctg 523080 cttcctgggt tcaagcaatt ctctacctca gcctcccaag taactgggat tacaggggtg 523140 agccaccatg cccagctaat ttttgtattt ttagcagaga tggggtttca ctatgttggc 523200 caggctggcc tcaaactcct gacctcagat gatccgccca cctcagcctc ccaaagtgct 523260 gggattacag gcgtgagcca ctgcacccag cccccttact tcgttgttat atttatgact 523320 ctttacctct tttcacagtc tagcagtcta aaataagcat cctatagaag aactactttg 523380 tttaaaatca ttgtagaaaa gttagctact cttattcctg atatattcca attattagag 523440 agaaaaactg aatttttgct cagaacacta gctaaacttg ggccagctga atgagcaaaa 523500 acaacaaaac aaacacagca ttttttttaa gttagtgagc aacaatttta aaattcacct 523560 tttaaacgtt ttcccttgct tcttttttta ttcttcttct atcttttcct tgttctgagg 523620 gaaaataaca agatactttt catcatgtat agaggggtat atttgaaaga gaactcagca 523680 ctaattctct tctagtccca gtcccagatg agttaaagta atgtgaatgg atggttgaag 523740 tatatggaga gtgtgtcaca cacagacctg gttttgttat taatggtgca tgcatttttg 523800 ctgtagatga aacaaaccat tgtggttggg tttttcggga agctgactct gagatggatg 523860 ctagtgtgaa gagtgtttat caaggagtgc cttatgatca acaaccgagg agggaaggac 523920 aggaagaagg actgggcgaa gaaagagtga gctgggatgc aggccaatga cagtgagctc 523980 tggagcaaga acagtccttc agggttgtcc tgagtttggg cagaattgct cctcaatcag 524040 tcactagatt gaggacactc caaaaaagag cctgtccttg ggtgaagtgg gcctctgcag 524100 ctgagacaat ctccgaggtg gccaataact tccagatgac atcaccccat gaattggtgg 524160 taacatgtcc tttcttgaaa ggaatctggt cagtgcaact cctcccactt acgtagatgt 524220 caaatggcta tacatgtggg tcttaaacac cttttcctaa acacattttt tcattcattt 524280 gcgcccactg gccgggcgtg gtggctcacg cctgtaatcc cagcactttg ggaggccgag 524340 gcgggtaaat caactgaggt caggagtttg agaccagcct ggctaacatg gtgaaaccct 524400 gtctctacca aaaatacaaa aattagccag gtgtaatggc gggcacctgt agtaccagct 524460 actcgggagt ctgaggcagg agaattgatt gaacctggga ggcggaggtt gccatgagcc 524520 gagatcatgc cactgcactc cagcctgggc aacaagatgg gaaacaagaa tctgtctcca 524580 aaaaaaaaaa aattgctccc gctttctata atgacatgag tccaatattt caaattagaa 524640 atgagaaata ttacagtgta ccatagtgta ttgtgttgta gttcatagct caattggacc 524700 tttgtcatca gaacaagttt caactcaaaa aatctcttta gttttgtgag tgctaagatg 524760 ttttttaaaa atgtattcag gtaatacttg tgcgtctgct gttaatgaga tcaagtaata 524820 ataggatggt cactgccagc aaggtgttgg ggtctgtggg agaacccaca gacaaatgat 524880 ggcaacacac gacaggaagc agcaaatgtc ctgggcgagg ggcagcagaa ggtccaaaac 524940 agcagccatg acacctggcg caggagaaca gcagggagac aaagaagaca aatgcagaca 525000 tcaacacaat accatcagag aaatatgcag tatgtgtttt aggagcagag gaagtggaca 525060 tttatctaat tctgggcata gggtaggctg agaagtcttg aggagccaaa aaagaatgtc 525120 caagaaaagc tgagttgaat ctcaaaaggg tctagcgcct gaaacggttt ccaaaagcag 525180 aaacaattga gtgtagtttt gccattataa gatgatcaga gtgagaatgg ggctcggaca 525240 gggtgtgggg acagaggtgg gtcaggtgca gttgctcaca tgtaagagcc cctatggctg 525300 acacaaagga tactcccagt aagcgaaggt ctgcatctgc acagagagga ccaggcctcg 525360 gagagttagc acatcctgct gaatcctaaa ggtgttggag cagaggtaaa tgctcgcagc 525420 aatgttttag aaacattaat ctggttgagg tgggtaaggt atatcacagt gcagaaagat 525480 gaaaaaaaaa aaaaaaagaa tgaccagtta ggacacaatt gaaagagttg taattaaaaa 525540 ggtgatagta ctgtgtttgg aaaaagagaa accacacaaa agacatgttg agaattggag 525600 tagacaatac atagcagcac actctcagca gctggacaca aaaagaaatg cacaactagg 525660 aacgctttta ttattcgaag cttcttgcaa ccaaaatatt ttgctatcac tactaagaac 525720 agagaattga agaagcttag attaagggga aacttgctat gtttggtttg ggatttgaga 525780 tacttctgag acatcaagat gaagatattg acatactact gaacaagcag gcatgaatct 525840 tgagaaggag tttttgtttg aaaatttaga ttaggagtca acagcattga gctgacagct 525900 ggggcaaagg aggtgctgag accatcaggg agagagaagg aagaacaagg ccaggtcagg 525960 acactgagga acaatggttc cattagcgta tgattagtaa gagacattcc tttccatctg 526020 aattgttgaa ctatttattc atggttttca atctcataat tcaattttgt aatgtgtagt 526080 atgattcttc aaatgaatgt gatatccacc ctcattaact tttgccatgg gatctatgaa 526140 ctctcataaa ctcttgtagg gtacttatct atcttttaga catttaaagt aaatacacat 526200 aaatgaacag agatggtgac tgatagggtt tggctgtgtc tccacccaaa tctcatcttg 526260 aattttactc ccataattcc cacgtgttgt gggagggatc tggtgggaga taattgaatc 526320 atgggggcag tttcctcata ctgttctcgt ggtagtgaat aagtcttatg agatctgatg 526380 gttttatcag ggatttccgc ttttgcgtct tcctcattct ctttgcctga tgccatccat 526440 gtaaggtggg acttgcttct ccttgctttc tgccatgatt gtgaggctcc cccagccacg 526500 tggacctgta agtccaatta aactctttct tttgtaaatt gcccagtctt ggatatgtct 526560 ttatccacag catgaaaatg gactaacaca gtgacaaaat ttattatttt aaagaatata 526620 ttactggccc atttaattaa cttagaaata atttcaaatc atatttacta taaaaaaatt 526680 gtgtgataca attctaataa tggaacaaag ctaacactgc aatggccata ttagaatctt 526740 tattgtgtaa aataaagaat aattctatat aggaaaaaca atatgcatta tgaaataata 526800 ccaggaaata aaataattca atccactgtt taaaattaca atataatatg aggaaagatt 526860 tttatcacat cagtaactat agcggacata atgttcttct attttatttc atttaatttt 526920 aagttccaag gtacatgtgc aggatgtaca agtttgtcac ataggtaaat gtgtgccatg 526980 gtggtatgct gcacctctca acccatcacc taggtattaa gcccagcatg cattagctat 527040 ttttcctgat gctttccctc cccttaccca tgctttcaca tgctttcttc ctctccctgt 527100 gtccatgagt tctcattgtt caactcccgc ttataagtga gaacatgcag tgtttggttt 527160 tctgttcctg cattagtttg tggaagataa tggcttccag ctccatccat gtccctgcaa 527220 aggacatgat ctcattcctt tctatggctg caaagtattc catggggtat ttttaccacc 527280 tttaatctct tggtgcccac tctgagtgag aattgtgaaa tttggcctgc atgatttagt 527340 tgttagtatg gctgtggtca aaaagtcaaa agataacaag tgttggcaag gctgtgtgga 527400 gaaaatggaa ccccgtacag tgttggtggg gatgtaaatt agtgtagaca tgataggaaa 527460 caataggaag tttcctaaaa aaatttatat aatccagtaa ttccactact gggtgtatat 527520 ccagaggaaa tgaaatcact ctgtgaaggg ggtacctgtg atcccacgtt catggcagca 527580 ctatccacga cagccaagac atggaaacaa cttaagtgtc cattggtaga tgaatggata 527640 aagagaatgt cacacacaca tacacacaca cacacatgca cacacgaaca ttatttagcc 527700 tttcttgttt gttttctcca agtcacagca ggttcagtgc cttgacactt tctgaaacta 527760 aggaagacat ggatgattgg gtccagctat ttttttctgt ccatggggaa catgttttct 527820 tagaatggag aatgtggcca gagaaaactt tggtctgctg tttttactta taactcctcc 527880 cctaaaggag gtatacttct catttgagta caccttaaat aattcaaaag atgtaaattt 527940 atcaaaatat actcaaaact cctacttcat tcatccacag aaattcaaat gtggtatttc 528000 aaatctatgt ctagagaaaa acagatactt gaaacatttt ttaaagtttt gtatgatttg 528060 ggctattaca aatatgccca agacacagtt ctttaaggaa accttaaaga tagatcctaa 528120 aagtcatctc caccacactg caaggacaat gccttgtcct tccctgtcct tcccacccag 528180 aaggcagggc caaagaattc cccactggct cactcttgcc tttttcgcct aggtcaatgt 528240 cagttaatat cagctcatat tgaaccccgc ggggagcttg gagtgagagg ctaagaaggg 528300 aaactaatgg aatctaagtt gatgtgaccc acgcagcctc tggtttcttt tagcacccac 528360 cggctccagc aatatcctta tcactccctc atcatatgtc tctgcatctt ggcctcctgc 528420 ccttcctgct aaagcaggtg caggtcacgg gaccagcagc ctaagtcacg gtaagctagg 528480 tgcatctctg gctgctgctg gttggaagtc accgatctca gggaaacaaa ctcacatagc 528540 aattcagagt tggcgcgagg accgtaccta aataaacaag gccagatatt gactcaagct 528600 ccccaactgg ccctgccagc agaggggaga gttggcacag tagttagaag tcctcggccc 528660 ctaggctaat aagactatga agaggagctt cactcttgtc cctgccatgt cgtcattatt 528720 aagtcctgga agtgtctgcc tgctcctctt ttctaagtca ttcttttttt tttttttaat 528780 tatactttaa gttttagggt acatgtgcac aatgtacacg ttagttacac atgtatacat 528840 gtgccatgct ggtgtgctgc acccattaac ttgtcattta gcattaggta tatctcctaa 528900 tgctatccgt cccccctccc cccaccccac aacagtaccc agaatgtgat gttccccttg 528960 ctgtgtccat gtgttctcat tgttcaattc ccatctatga gtgagaacat gcggtgtttg 529020 gttttttgtc cttgcgacaa tgatagactg gattaagaaa atgtggcaca tatacaccat 529080 ggaatactat acagccataa aaaatgatga gttcatgtcc tttgtaggga catggatgaa 529140 attggaaatc atcattctca gtaaactaag tcattcttaa tgacttcagg attgtctaaa 529200 gtgcagagtg taaacatatg ttcatcatca cctctgaaag tttttttcta aaaaacatta 529260 ttcaatcaaa atgaacaaga catccaggct cggtggctca cgcctataat cccagcactt 529320 tgggaggcca aggcaggtgg atcacatgag gtcaggagtt cgagaccagc ctggccaaca 529380 tggtgaaacc ccgtctctac taaaaataca aaaaaaatta gccaagccta gtggcgtgtg 529440 cctgtaatcc cagctacttg ggaggctgag gcaggagaat cacttgagcc cgggaggtgg 529500 aggttgcagt gaggcgagat catgccactg aactccagcc taggcaacaa gagtgaaaac 529560 tccgtttaaa aaagaaaaag aaagaaaaga aaaaaaaaga acaggacact atttatccca 529620 ctagttgtgg gaaataaaaa agataaactt gatagatctc ctgccctcct gggtcactct 529680 acttaagaaa atgggcacgt ccataaatca ctgtactcac ttgagtcatc aatgtgataa 529740 attccataca agagttttga acaagagtga gtagaggaac cgcttacttg tgttgtatgt 529800 acattgtgga gaactgtatc agactgggtc agtaatctaa aatttagcta aacgatgttg 529860 ttaagtagca gaattgacca gataaccaga cttatgggtg aggagatctt gaaggtatac 529920 cccggactag aaactcccac ctgctcacag cctcatcatt tcggagtcac gccttgcact 529980 gaactggaca gtaaatagcc ctgtggctgc gcagaagagc tacttgctgt ctatttcaat 530040 gcaagctgat aatgaactgt gtttcattat cacctcgtta cacatgaaga gatagaatcg 530100 cagagctaaa taaactggat caagataaca ctgctaatca cccagaattg acgagcaccc 530160 cacccatgat tttatcaaag tcttatacgc ctcttctcta ggagaaatca aagcatttcc 530220 ctccatgaag aagaatatac aattaatttt taagagacaa gacagaaata tatcagtctg 530280 atctaatatt cttgttaagg gtttagatag agtaagagtc aaaattgaca tttggcagta 530340 ttcaatggct ctgagctgcc taggaaaagg acccccgcca ttatgtagag tgaaatacac 530400 aagcctggta ataaatgacc tttatcagat atttacgtac ttcttgtaga aagggtatgt 530460 caaaagcggt gtgtgtcata ttcaggattt ctgctcctat gatatacaag cttttactgt 530520 cagcaagatt cagataattt accttattta ggtgatatca tgaatcaggt aatcagtgtg 530580 tctcaaatag gaggttcagc tttcccaaaa tcatgagaag agttttctaa tcactggagt 530640 tactttgtgc catcgatctt atgtcttatg aatataaaat ataaggctta agacgcttta 530700 aaaattttat gcatttgtat gcagcagact tgcaactcac agctgatgca agcaaggcaa 530760 cttaagcagt gaagaaagaa ttgacatgat tgacaaatag gtcttgtgat ttaatttaca 530820 ttaacaatga tgtaatgtgc atactgacct aatgtgtcct tacataatgt ggcaagcaaa 530880 gcaacacata gcaaacctaa ttttgacatt cttctgggaa aacgcttttc cttatgacta 530940 aacttttctt taatatttat tttaaccatt ttggaaaggc ttttttttgg tagatatgtt 531000 ttaaaatatt ttaaatgtat ctttttattt aatatgttaa ccgtgactta taattcagaa 531060 tgctaattaa gtattacgat tttgtattaa ttacaaaaat gctgactact aagggcaatg 531120 tgctcccaaa caaaatgtca tccaactact gtgtgtgttg cgtttttgtg tctgttcttt 531180 ataatttact tttagtttct caccctcctc cttttgcttg ccaattgtgg cttcttacta 531240 agccctcttc aatatgcctg aactcccaga atctgattta ggccaagata tcagataact 531300 gacagtgttg taatgattta aaataagatg ttcaaagcaa gggattatcc ttggagtgat 531360 gtgtatgaga tttagtgcat tagctttctg acactggttt ttcagtgctt tggaagtgta 531420 cttcttgatt ttcagccctg ttgctttgta ctaaagtaat gataaaaata ttccttaaat 531480 accatacact gatgaattgc aaatattttg gaattataga aaacacaggg ttttggtttt 531540 cgttttggtt ttaatgctga ttcttctata gctacctctt acttctgttc ttgaaaattt 531600 gtatgtgcat atatttcctg tattctataa ctctcttatg ctctaaaggg acattctaat 531660 actttacaat tatttacaac ctacactcta tgttttcctt tttttttttt gagacggagt 531720 ttcgctctgt ctcccatgct ggagtgcagt gacatgacct tggctcactg caacctcagc 531780 ctcccgggtt caagcaattc tcctgcctca gcctccctag tagctgggac tataggtgca 531840 cgccaccatg cctggctaat tttttttttt tatttttagt agaaacaagg tttttccatg 531900 ttggccaggc tgctcacgaa ctcctgacct ctggtgattt gcccacctgg gcctcccaaa 531960 gtgttgggat tacaggcgtg agccaccaca cccggccttc ttattaaata gctagattaa 532020 aaaatatgct atgtcttacc tttctttctt gatttggaga aagtaaatcc tcacgtattc 532080 cttctccctg ttgtaactga tagagaaaat tagcccagta acctttcaac ttacctgttt 532140 tttcctcatc ttaaaggctt gtgaaataga acaaatgcta agaaactgat tcagatacac 532200 aactaagttt gagaattact gtgttaactc attcagagct caaggcagca ctctatttta 532260 taaataagga aactgagacc ctgagagggg ttaagtaact gtagtaagta gcatagctga 532320 acttaaacca aagtagcctg gctccaaagt tcttatctta gaaaaattgt ctgtaattca 532380 gacagtaagc accaagccaa ggtttgtctg agtatgctga caaccaggtt tttgtgtcca 532440 ggaaatcaaa ggggaggaaa tgtaattatt ttctttaata aagcatagca atttagtatt 532500 aataatattt acatatatag tgagcattta tgccacttgg gggcaagaga tttaaagaaa 532560 tacaagcacc tttggtacaa catgacattt tctccagcac attccaactg agaacgttca 532620 tacctcagtc tgacccgatt ctctccacca gcactggata gaatctcatc ctgagacctt 532680 tatctcttag catcagatca gcccttttca atcccaaaga tctaacttta catggagaat 532740 ccacaggagg attgacattg agtatgcttg tcggtacctt tgaccattta aaaaaattaa 532800 tttccctggt aaaacctaac ttgagctacc tacttcttcg acctctggct gtacttgcaa 532860 ttttgagttc tagctcccaa ctgcttttga aagcagacag ccgtcatagt gataatacga 532920 aataagagaa gcgccatggc tgcacttcct tgctgtctgc ggcctatggc tatatatgga 532980 agctccactg gcagaggctg atgggttatg ctcattgctg tgtgcccagc acgttcactg 533040 ctgccacaca catcccaggt gctcaataaa catgacttga ttgaatgaac aaataaatga 533100 atgaatggtt ttctattcaa atttctcagc cggatccctt acctcttcct taagctgata 533160 gttgaaatgg acttacaatt gttgaataaa ctgtagaaat ctttaataac ttcattagga 533220 aaaactcgta atataataat tggtttatat tagattatca catgattaat catcttagtt 533280 tgtactctta gtcatttcca agcccctgca tacaaataaa cctttttctt tccaagaatg 533340 tatgcaaaaa cacaaaaaag gcttacatta caggctctga tattagttat attgacatga 533400 tttaagccct ccgagaatag ttaactagtt ctaagaccaa aagggcaagg taacatcttt 533460 gagtatcact tttcccatct gcaaagtaaa gcaataaata actaatccgt aaggctgatg 533520 aaagagcata ttactttgct cataactaac aagtaacagt tagagttcaa atgtggttca 533580 tctgactcca ttttaactat ttcagaatgt taatacccta tgacatcatc taggagggca 533640 ctgaggaaga gagttcctaa ggcaaggtgg acaaaacagg catcactcag caaagctgaa 533700 tcaggaaaga gctttccagg ctgagtttgc ttgcagtgtc catggcaggc caggctgaag 533760 gctataaccc gacctcctta gcaatacatc agcaagtcaa ataacctgcc acggaccagt 533820 tcacaattaa aagttacaca cgtaaagtgt gcaaaactaa gagatgcaaa gtaaagatgt 533880 agttattcta atatgaaata agaatttata attaatggtt gttattagtt ggacataaca 533940 gagaacttta acaataaaat tggaatattt attttacttt tttttttttt tttagttttt 534000 tagacacagg ctggagtcac ccaggctgga gtgcactggt gccctcgtag cttactgcag 534060 cctcgaactc ctgggctcaa gggatcctcc cgccttggcc tcctcagtag ctgggaccag 534120 aggtgcacac catcgcacct ggctaatttt ttaaaaaaat gttgtagata tgggggtccc 534180 gttatgttgc ccaggctagt cttgaactcc tggcctcaag tgttcctcct gccttggcct 534240 cccaaagtgc tgggattaca ggtgtgagcc accacatcca gccaaaattg gaatttctgc 534300 ttcttcagtg ggtttagaat atgcctattt acaaggcagg aaacaattag aaggggaaca 534360 gtaattgtag tgtcatagtc gcaaagtagg aaagaaacct cctcttgtat acatcatttt 534420 aaaaggcttt gaaggaaaac caaacctaaa tccctctttc acactattta cactacagat 534480 atagtctgaa atgttttcat tcaaaaataa tttttaaatt aaagtttgtt gaacaaaatt 534540 aacttgctga agtacaaatt gaaccatggt ttttatttaa aatgatgaga acattcaaat 534600 aatagaagca gaatttcaaa tttgctacag ttcctgtatt tctatgctgt atctatgatc 534660 gtctgtacta ccctttcagt gccgtataca gggttaaagg aaaagcaaat gtagaataag 534720 cacagttcgt tattatcttt cttttttctt gcagttccgc ctttcataca accctttgag 534780 tttccaagat tctccattgg gcagcgggtc ttcatcccct gtgttgtggt ctcaggggac 534840 ttacccatca cgatcacctg gcagaaggat ggccggccaa tccctgggag ccttggggtg 534900 accattgaca atattgactt cacgagctcc ttgaggattt ccaatctctc gctcatgcac 534960 aatgggaatt acacctgcat agcccggaat gaggccgccg ctgtggagca ccaaagccag 535020 ttgattgtca gaggtgagca aaggatcatg agccatgtgg catctgtaga gttgatttaa 535080 caatggttta agatgatggg gcttgaaata tttcgaaaat aactggaact tagaaattca 535140 gttttatctc actaaaaaaa aaaaaaaaaa aaaaaaaaaa tacgactcta aacccaacca 535200 tgaattcccc taaactccaa gataaggttt tatttaccta aaatatgttt taaataatta 535260 atagctaaga aggtgggaac cataggattt aattcatgaa ataaggcttc cgtatgctaa 535320 gccaatgagt tttgaggact aacgtccgtg agcttttgct ttattgtatt catataatat 535380 ttttagtatt tcttatttca ataaatggtt ttttaaaaaa tatgtctcaa agctatgtat 535440 caaagttttt ctaaagagcc atgaaatagc ttttcataat gtttgtttta gttttagaaa 535500 tgtggttttc tttgcccatc tattctattt agcattaaat ctatcattat tttgggacgc 535560 cattgcaacg ttttaaaatt aagcagagta tggtagtact tattcaaaaa aattaaaata 535620 gggtaggcta acttgtagaa aactggcagt aatctcatta catctaaact gtaagcttca 535680 gtcttatttt gaacttctat tcaagtcacc aaattcccat taaggctcac actcttcatc 535740 tatgaaataa gctgctagtg ttctctaatg tatatcaaac acagacattc tgtgatgttt 535800 atgattctcc aagagtacta tacattaatc taccattaca atattcatcc acattgcaaa 535860 agtaactgtc tgaagttaaa gatttatatt aacaatgatt atttgcattt taaaattccc 535920 cagattgtgg tcccagagtg gttgttagga gggggaggat ttctgtaatt tcccagagag 535980 tggagatagc tctttcttga gcaggagatt ctcatgtcct tcttcattcc ttactccttg 536040 tccccttgat acctcttctt ccttgccagc tgggaagaaa tgcacttttt atctacctgc 536100 cagcaaaagg aagtgacaca gacttagaag tcataggaag aaactaactt tgtatttctg 536160 aaaaaaaaaa tttccaggtg aataatttag aaaatatata ttcaattaga cacaaactta 536220 gcagcctcat gacatttttc tcatttccac cttgcacttt ggagtggaag aattgggata 536280 cttgattttt tcccaaattt tgaaagataa ataaaaaagg gagccaacct agtatctgtt 536340 tcccaagcgt tttcttataa gcagagttaa ctcttgggtt tgtgaagggc aaaatagtac 536400 atcagcctgc tttctatata atctgctctg aaggatccag gccaggaatc tgaaacgtca 536460 gataaaaatg tacggggatg ctttttgtac aacttgccct tgcagaaaag gcaaccagaa 536520 gtttttaacc aaggcaaaat cagatgagct gaaaatgagc ctagctattt gggataatgt 536580 agctgatcat gatatgactg atgtctccat gtgattgttc ttcaaatatg ttaaataagc 536640 tttagttaaa ttaatattaa atcaccagtg agataatgca gcctagagga agaaaatgtg 536700 cttcacaaac aggtcagtgt gactggagaa acaggcaggg acaaggtgat gtgggactgt 536760 ggttctcaat ccagacagtt ctgtagaatc tcctgggagg cttaagaaaa cactgatgtg 536820 cattttttgg tcccaatcta caccaattaa atcataatct ttaggggtaa atccatcttc 536880 cagatctctg gggaattgtt cttttttccc aaaaatcact agttagtggt tctcaaactt 536940 tgttgtacat tcagattgca tagggaggtc taaaaaggtc ctgatgacca ggatgaagct 537000 cctgtcaatt aaataaccat ctttggaggt gggacccagg catcaataat ttgtaaaatc 537060 cacaggttta ttctaatatg tagccaagtc tcagttccag ccccctgagt aattagaacg 537120 tgcagccatt ttgaggtgtg gattttcttc tagattaaag agttggcact gttgacttta 537180 accaccacag cactatggcc tgattgatct ttttagttgt cacactagta gctgtctgaa 537240 gaatggactg ggctagaaag caagaagagt agttaacagg ctatttcaga cattcagaca 537300 agataaaaat gccttggatg aaggtgttaa tgttaaggtc atgagaagca gtggaattca 537360 caatctattt tggcggtaaa gcaaataaaa cacgcttatg gagtgaatgt tgcaaatgag 537420 ataaagaaga acctttagtg gaatcatgct ttgcctaata acaaggtgaa tgaaagtgtc 537480 tttagcagaa gcagagaaga aatgaggaag aacggtattg acaaggggaa taatggtcaa 537540 tgatatggga gaagcacctg tcccagcagt cactagggca ctccagcatt taaggcccca 537600 gaataagaga aggaggaatc agcagaagag acgaagaggg aaaaggagca gcctgtaaag 537660 gaggagaaaa tccagtggac tgtggcactc tagaagcaaa atcagaaata aatcgagaaa 537720 gagaatatta aacagtattg aatcctgctg aaagtagaca aagaggaaaa ccaagagttg 537780 gtcactggtt taggaagatg gatattgttt atgaccttga tggatattgt ttatgacctg 537840 gtgtcattgc agcgagggct tgattagagg agcttcagaa aagaaagaag gtcaatgtgc 537900 aggaactcag aaaacacaac tatttttata tttttaggaa ttttgctatc acaggaggca 537960 gtaaaatgga gacaaagttg gaaatggaca tggggcaagg gcaggagtta tttttaagac 538020 tggatacttt acagcctgct ttatgcttat gagaataagc cagtagagag gaaaaaaata 538080 tgtgtcaaga taaagaggag attattacag gatcaaagtc cttgagttag tgaatgcaac 538140 cagaattctt tgtaccagtg cagtagtacg ttcaaagtag tataataaca accatggtgt 538200 gaagctccag taggtagcac caacagaaat gattgaaaat tatagggaag ggggatgttt 538260 tgggtcaaag aagtggaaaa acaaaaatta tctaatagga ccatcacaga gtaacaggta 538320 acacatttat cctcctacta caaaccaact ataaaattgg tctaatatat ataagaactg 538380 ctttcaggaa caaaacaaag tgcatgaagt cagttccaaa ttcaccccag atagctgctt 538440 ggggtacttt ctgcacatga cagagagtgc agagcccaaa tagatcacag tgatcttggc 538500 aggtggagaa aacagagaga gaaattgaaa gatactaaga tgattactgg gtattgaagg 538560 acaagctact ggagattagg gagctattca aagaaaggtc tctagaaatc tgtacagggc 538620 tcctttgcag tttcagctga atactgttct tcacatgcac agggtgctag cagaagttgc 538680 acattgcttg ggaatgctgg agttctaact agccagaata ggggaattca gccgcaatct 538740 caggaatgcc acaccctagg agtaggacta atctatcccc agcataaggg ttactctaga 538800 ccagccctaa aagagcctaa gaagattctt ggcaagataa aacttctcca ctagtaagtt 538860 aattgtgtgc ataaacaata tttgacacta aaaaggaaga caacaaaatc cagaccccca 538920 acagcatagc gtatccacaa tgtactgcat tcaataaaca caggcacacc tgattttatc 538980 acacttttct tttttgttgt tgttgttgtg tttttttatt ttattttatt attattcttt 539040 aagttttagg gtatatgtgc acaatgtgca ggttagttac atatgtatac atgtgccatg 539100 ctggtgtgct gcacccatca actcgtcatc tagcattagg tatatctcct aatgctatcc 539160 ctcccccctc ccctcatccc acaacagtcc ccagagtgtg atgttcccct tcctgtgtcc 539220 atgtgttctc attgttcaat tcccacccat gagtaagaat atgcagtgtt tggttttttg 539280 ttcttgtgat agtttactgg gaatgatgat ttccaatttc atccatgtcc ctacaaagga 539340 catgaactca tcatttttta tggctgcata gtattccatg atgtatatgt gccacatttt 539400 cttaatccag tctatcactg ttggacattt gggttggtcc caagtctttg ctattgtgaa 539460 tagtgcctca ataaacatac gtgtgcatgt gtctttatag cagcatgatt tatagtcctt 539520 tgggtatata cccagtaatg ggatggctgg gtcaaatggt atttctagtt ctagatccct 539580 gaggaatcgc cacactgact ttcacaatgg tagaactagt ttacagtccc accaacagtg 539640 taaaagtgtt cctatttctc cacatcctct ccagcacctg ttgtttcctg actttttaac 539700 gattgccatt ctaactggtg tgagatggta tctcactgtg gttttgattt gcatttctct 539760 gatggccagt gacggtgagc attttttcat gtgttttttg gctgcataaa tgtcttcttt 539820 tgagaagtgt ctgttcatgt cctttgccta ctttttgatg gggttgtttt ttttttcttg 539880 taaatttgtt tgagttcatt gtagattctg gatattagcc ctttgtcaga tgagtaggtt 539940 gcgaaaattt tctcccattt tgtaggttgc ctgttcactc tgatagtagt ttcttttgct 540000 gtgcagaagc tctttagttt aattagatcc aaaaagaatc caggaccaga tggattcaca 540060 gccaaattct accagaggta caaggaggaa ctggtaccat tccttctgaa attattccaa 540120 tcaatagaaa aagagggaat cctccctaac tcattttatg aggccagcgt catcctgata 540180 ccaaagctgg gcagagacac aaccaaaaaa gagaatttta gaccaatatc cttgatgaac 540240 attgatgcaa aaatcctcaa taaaatactg gcaaaccgaa tccagcagca catcaaaaag 540300 cttatccacc atgatcaagt gggcttcatc cctgggatgc aaggcttgtt caatatacgc 540360 aaattaataa atataatcta gcatataaca gaaccaaaga caaaaaacac atgattatct 540420 caatagatgc agaaaaggcc tttgacaaaa ttcaacaacc cttcatgcta aaaactctca 540480 ataaattagg tattgatggg acgtatctca aaataataag agctatctat gacaaaccca 540540 cagccaatat catactgaat gggcaaaaac tggaagcatt ccctttgaaa actggcacaa 540600 gacagggatg ccctctctca ccactcctat tcaacatagt gttggaagtt ctggccaggg 540660 caattaggca ggagaaggaa ataaagggta ttcaattagg aaaagaggaa gtccaattgt 540720 ccctgtttgc agatgacatg attgtatatc tagaaaaccc catcgtctca gcccaaaatc 540780 ttcttaagct gataagcaac ttcagcaaag tctcaggata caaaatcaat gtacaaaaat 540840 cacaagcatt cttatatacc aataacagac aaacagagag ccaaattatg agtgaactcc 540900 cattcacaat tgcttcaaag agaataaaat acctaggaat ccaacttaca agggatgtga 540960 aggacctctt caaggagaac tacaaaccgc tgctcaatga aataaaagag gatacaaaca 541020 aatggaagaa cattccatgc tcatgggtag gaagaatcaa tattgtgaaa atggccatac 541080 tgcccaaggt aatttataga ttcaatgcca tccccatcaa gctaccaatg actttcttca 541140 cagaattgga aaaaactact ttaaagttca tgtggcacaa aaaaagagcc cgcgtcgcca 541200 agtcaatcct aagccaaaag aacaaagctg gaggcatcat gctacctgac ttcaaactat 541260 actacaaggc tacagtaacc aaaacagcat ggcactggta ccaaaacaga gatatagacc 541320 aatggaacag aacagagccc tcagaaataa cgccacatat ctacaactgt ctgatctttg 541380 acaaacctga gaaaaacaag caatggggaa aggattccct atttaataaa tggtgctggg 541440 aaaactggct agccatatgt agaaagctga aactggatcc cttccttaca ccttatacaa 541500 aaaattaatt caagatggat taaagactta aaccttagac ctaaaaccat aaaaacccta 541560 gaagaaaacc taggcattac catttaggac ataggcatgg gcaaggattt catgtctaaa 541620 acaccaaaag caatggaaac aaaagccaga attgacaaat gggatctaat taaactaaag 541680 agcttctgca cttttctttt cttccttttt tttttttttt ttttgagacg ggatcttgct 541740 ctgtcaccca ggctgcagta caatgggcca atctccactc actgcaacct ctaccttccg 541800 ggttcacacc attctcctgc ctcagcttcc tgagtagctt ggattacagg catgtgccaa 541860 catgccaagc taattttttt atttttagta gagacaaggt ttcaccacgt tggccaggct 541920 ggtctcgaac tcctggcctc aggtgatgca ccccacttgg cctcccaaag tgccgagatt 541980 acaggagtga gccaccatgc ccggccacac tttgctttat tgtgcttccc agatatcgca 542040 ttttttacaa gttgaaggtt tgtggcaatc ctgcatcgag caagtctatg gggaccattt 542100 tttccaacag tgtgtgccca cttcgtgtct gtatgtcaca ttttggtaat tcttgcaaca 542160 tttgaaactt tatcattatt attatgtctg ttatggtgat tggtaatcag taatctctgg 542220 tgttactatt ataatgttac tattataatt gttcagtagc catatgagat ggcaaactta 542280 atcgataaat gttgtgtgtg ttctgaccac tctactaacc aaccatttcc cagtctccat 542340 ttctcagctt ccctatttcc taagacaaca atattgacca tttctcagct tccctacttc 542400 ctaagacata acaatattga aattaggcca atgaatggcc ccacaacagt ctccggtgtt 542460 tcagtgagag gaggaatcat tcattgcaca tctctcactt taaatcaaaa gctagaaatg 542520 attgcattca gtgaggaagg catttgaaag ccaagagagg ccggaagctg ggcttcctat 542580 gccaaactgt ttgccacatt gtaaacacaa aggaaaagtt cttgagggca atgaaaaatg 542640 ctactccagt gaacacacaa atggtaaagt gaaacaacct cgttgctaat atggagaacg 542700 tttaaatagt atggatagag aaaaccaaac cagccaccac attcccttaa gtacaagctt 542760 gatacagggc aaggccctaa ctctcttcta tgaaggctga gtgacgtgag gaagctgcat 542820 aagaaaagtt tgacctgggg tcattgtaaa gcttagcaca ttgtttgata gcctgggtta 542880 gtgggaagat ttgtaaagac ttgatctaaa ataaattagc tgttgtcttg aagaaaatat 542940 aagaaaacaa aaacaacacc ccaaaagcaa aaatctctta gctgttatgt atgagccaat 543000 aagagccaaa tctcatagct cttatgacag tggactgatg gtttccctga tatcctgctc 543060 agtggagtga ccttggcatt gattaaggta ttagaaataa cgcattaggc ttcatgaaag 543120 agcactcctg ccctttgctt cctgttgtgg tctctagacc actcacagga aagcaccaac 543180 acaacagttc ctatctgtga ttccaaagga gggccgtttt ctcacacttt tttatatctt 543240 ctgatgggtc aatggtttct ggcttttaat ggtgaactgc cacatagaga aacaagcaca 543300 ttggctaaaa tagttgactg tcagttgaca ggaaaaatga aaatcataga aggttgctat 543360 tttattgcca tctgttgatc caatttttga tagaattctc atgctatgat tttacttcat 543420 tcattcattc ttacacaaaa tatttcttaa atatttgttt tataataggt gctgttatga 543480 gtgccgagga taccatggtg attaaaataa agacaccaag tctctgccca ttaaggttca 543540 aagtctagtg aagggaagag ataatgaaca aacaatgtca gttatctaca aggactatga 543600 aaaataaaca tgttgtacgt ggattgagaa agatggggat gaaaatagta ttttaggtag 543660 gctgggcagg ggaaggcttt ctggagagat ctttgagcag agacttgact gaagtgaagg 543720 cgtacgtccc agggaattgt aggaagcgag ttccaagcag agagaccaac aagtctgaag 543780 actgagtgtg gagtgagttt tgtgtgttca cagcccagca agaggcccaa ggtgcctcct 543840 attaagtaag agaggacaga aagtgtaagg cagagatata agcagaggcc aggccatcta 543900 ttctcagaat gatgggaaag caataggttt aattgtcagt gtcgtaaatt aaatcttacc 543960 tagactttgg ccaagtccca tctcaactaa atgtcaccaa gtagagaatg gtggtattta 544020 tccatgcacc ccctcccacc tccaccaaat ggctttcatt aaaactgaat ttctgcccag 544080 gtttacagct agggaaacct aaattcattc tttggaaata tatagcaact tagaagccat 544140 ggcttccaaa cataaaacgc tggactacat ttaaaactag aaaaatgcct gtcttattat 544200 aaccatagta ttatttcttt aaaaatgaaa caacagaagt aatccacccc ccaccaacac 544260 acacaaaata agcagatcaa gccaaagacc tctgtgtttt aaacaacctt cattttaggc 544320 aacaccagga gtaaacttcc tcaaagaaac ctatttgaaa cttcagatac tctcagccta 544380 tgtggatccc atgacaagat tttggtattt tggaatatat atcaaattgt tctttttggg 544440 gagacaggag tgctggttat gtgcacgtaa ttatgattca gagaagtgtt tggcaagttt 544500 agccatattg catcttggag atgtgatgta attatgtagt tgaacctatt catctcttta 544560 attactcttc ctccctacca gaaaaaccgc tctgtattag tccattttta tgctgctgat 544620 aaagacatac ccaagactgg ctaatttata aagaaaaaga ggattaatgg actcacagtt 544680 ccacaggtgg ctgggaggtg aaaggcatgt cttacatggt ggcaggcaag agagagcttg 544740 tgcaggggaa atccccttta taaaatcatc agatctcatg agactcattc actatcacga 544800 gaacagcatg ggaaagatcc gccccccgtg gttaaattac ttcccactgg atccctccca 544860 caataggtgg gaattgtggg agctacaatt caagatgaga tttgggtggg gacactacca 544920 aaccatatca tgatctattg gaaaacaaac tatattggca agccggctca ccacaatata 544980 ctaaataatg tgttatacta ataaaaggaa atctaaatat catctttaaa aaaggaaacc 545040 aacaaccttg gggaattata cacccagaca atatagagta ctggtggtct ttttgttctg 545100 tcataagttt tggcccaaac ggcaacagtc ccaaaggctt cacatccttc catctcaggc 545160 tctgtatctt cttggccaga gtcctcctat gaggctgtct tctgctgtcc ctcagatggc 545220 acttccattg ggtccactct tctcaaagac ctcaggcttt gggggtcacc ctgatctgcg 545280 ttattaactt agccatgctc cgtttcccta gtctataaaa ctgaagtaat aacattcatt 545340 gattcatgtg tcctttcaac gcatagttgc agagtgcttt ctgtactgca gatctgtgct 545400 gtgcgctggg catgccatgg cctgtgagaa aggaatggtt cttgttctca tagcatgcac 545460 agcctggtat gggacacaga ctgttaaaca gcaataccag atgagcgtaa taaaggctat 545520 ggtaagtaat taaggcctca gagaagcact taatcttatc cacagcatca gaaacaaatg 545580 tgcctgactg agtgagtgct aagctaagat gcaaatggtg aatgggaact tattaaacag 545640 acatgaagaa gcctgtgtga agacccagca gcaagaatgg tcttggggac tggataatag 545700 atggggtttt agaatagttg gggcaaagcc tgcaagagga gaatgtcaca gaatgcaact 545760 ggagaccaag ggctcaagtc ataaaaatcc tttaaaatat cccaagagtc tggattatac 545820 caaagggcca tgggaatatg cgatgctttt aagcaaggaa gtcacatcat ccaatttgtg 545880 tcttagatcc tttaggtccc tgagtgaaga atgaattcaa gtgggacagt tcgtggcagg 545940 tagaccagtt agggggctga gaaatctaaa taagaggcaa tatgggcctt gtcctaggtt 546000 gggttccctt gaaagtagag tgtgaggcac agaattggct ggcaggttat ttatttggga 546060 tgtcattcct ggatcccaga atggaaagaa tgagattaga aagggagaaa agaaaatcag 546120 taaaagttgc tttaatgagc tggttgctgc tatgggcaac tggagctcat tcctactggg 546180 agccttctaa ggaatcacgt agaacagtgg ttcttgaagt gtggtctctg taccagcagc 546240 ctcagcatca cctgggagct cattagaaag gcaaaatatt ggattccacc ccagatgtac 546300 tgagtcagaa tcactggaga caaggtttag caatgtgtgg tttaatcagc tcttcaggtg 546360 attctgatgc cctctaatgt ttgagaagcg caggcacaga gcaggcctca taattgcccc 546420 actggatcgg aggaaactga ggcagaggca gagaatttat accctgactc ctgtccctca 546480 gtgatggaca attgtttttc acatgtcaag gttgcaccag taaggtgggt aaaggctcat 546540 gacttctgag aaggcctgag acagcaaaga gagggccgca tccccttagt gcagtgtcct 546600 ggcaaagtgt gtggaggtgg agctgtcctc ccagaggtgc tgaagccggg tggacagagg 546660 ggctgtgccc ctttcccaca taaccagact actcactgtg actggggtgt ggcagtggag 546720 atgcagagaa tttgaggata cattttcaag aaataatcat cagcacctga taaaaagaaa 546780 tgaaagaaga ggatatgaaa ggaaattcca tttttctttt ttgaggacct taatggatgg 546840 tgaacaggaa caggtaccat tttggaaact tgaattagag gtacctgtga tataagctaa 546900 tgatggaagg atatggtgct ctacacacca agggaagata aaggcaatca tcgtgatggg 546960 agtgggtgaa atagctcagg aggtttgttg agtaagatgt ggagaagatt gaagacaaca 547020 ccctgagaag aaggagaggg ccacagtggg ggatcctctc tttaataagc aagcaaagta 547080 agaattgtct tgagggcaat tctgggaggg gtcaaaggat ggaactagga gtacgtgaaa 547140 cccactgagt actcaggaaa tgctcacttt cattactaag tgactccttg tgggggctcc 547200 tgattctttt aggacaattt cttaggctgc cattttgtag aaaaaaagta tctaggtcga 547260 atattaatag tttctttaaa aaatatctgc actttttaaa aaataaactg ctgcttactt 547320 taaaaaattg ggaactttgt tgtccctagg gataatggtc attctcatat gcttagagca 547380 tatgagaatg atgtcattag ttacatgtta aacactgggt cctcattcag acactcccct 547440 gccctggaat tttaatctta gctggtgatg cagctgtctc aaagtgatga caacccccag 547500 gggaccatat gcctgttgtc ttcacattag gctctgggca ggcaaagaaa tttgtttaga 547560 aacttattac tacttttccc aggaatccat cacctctaat tttgccaggc agaactcaac 547620 ccaagcatat tcttaaggtg tcagatctga ggggtgtggc ctcaggtctt cttgatgtaa 547680 gtacatggat gttcccagtc ttagagttct tattgtaact cacaagttca ctttcatgaa 547740 agggacctac gtattcactg gtacacgata ataaatcact tagggattga atatttacat 547800 tcatgacagt cttctgtcaa aatttaaagg aaatgtatat gatttggctt attcatgcac 547860 ttagtaaaat atagcatttt cctcaaggtg gtctcaagtt gcatggtata tcagccaaag 547920 accaaacatc tgagctatta attattctct ttgctataaa aattaagaag ctcacttact 547980 gcagaagctt ctttcttagg tcttcatgtg actgtaaatc actggggtat ctgaagagag 548040 aattccaatc tatgagcaaa gaggtgtacg tgggaaatcc cctggctact cctaccaggg 548100 tcagaaacag ttttcaatga tacggggtaa ttattctact aatttaggga ccgtttttat 548160 ctgtaactac cttatactta ccgtatttct atggttgttt ctcatataca cttctttgat 548220 gagattttaa ggaacatttc gttggattag aaccaaattg aggggaggag taatggatca 548280 attatgatta gacatgcttc cagagggaat gcaagagatt ttctaccctg tccattgatg 548340 agcaatttct tgctcttggc agaacttgag ccaaatggag cacagaatgt ggatggctgc 548400 agattttcct tccaccctgc agagaataat tttggcatgg tgtcttcaac tttgtcacct 548460 gctcttgagt tgattggtca cttttactag aaaacttagc tctaaataat ctctaccata 548520 tttcttagag ataatttcct cactcagaga tagtcattcc ttattatctt attttaaata 548580 tattttcatt ttcttaaata cattttgtct ccgaatacca tctacatgaa gtaacattgc 548640 ttatcactta agcaatatct cagaaaccca ttggctgtgt aaattattta tttcatttgc 548700 aagttgggaa ctttgctcat caagaatatg tcaggccgtg cgcagtggct cacgcctgta 548760 atcccagcac tttgggaggc tgaggctggt ggatcacgag atcaggagtt caagaccagc 548820 ctggccaaga tggtaaaacc ccatctctat taaaaataca aaaaaattac ctgggcgtga 548880 tggcaggcac ctgtaatccc agctactcag gaggctgagg cagagaattg cttgaacctg 548940 ggaggtggaa gttgcagtga gcagagaaca tgccactgca ctccacctag gcaacagagt 549000 aagactccat ctcaaaaaaa aaaaaaaaag taaaagctaa acatacctgc atttactaaa 549060 ttaatcaaca ctcttacagc agttaatatc tccacagttc tgagaacttt tctaatctta 549120 atttatttga tcatcttaac aatccttaaa atgagttcca taatcatctc caattttcag 549180 ataagtaaat tgagaccaag agccatttta cagtttgcac aaaattgccc aacaggaaat 549240 agaaaagctg gacaccaagc caatgtgttt aacacttggc tttatgctgg tagtcattat 549300 tttctggtgc ttcttcatgt gtaaatcatt ctacagaaag taaagctaga aaattaaaag 549360 caatattttc tccagaaaca ctgcggtgaa ttccatctct ggctgcttct tgtgtcttga 549420 cattttccct tcctcctttg ttattttatg gccaaagcga tcgtcacgtt ggctcagatc 549480 attgtaacaa gcttctaagc cccttgctaa cttaggccct aaccatcttc tcagtctatc 549540 atatgtggca gctgagttcc tatctacctg taacacatag gctcacattt atgtctcaaa 549600 attaagaatt ctgtatcttg caaggctgat gagattagcc ttaccaggaa tttctaagta 549660 tctactatat ggtgtagata attcatctct tctcacatag tttatgactg cctcactgaa 549720 agtctaccct gtaatgaatc gctgatctgc tgggaaagat acggggatta gaatactttc 549780 agatgctacc ttttctaaga gatgtgatac atattaaaat cctaatggct tatctcaaaa 549840 aatatgcttt ctttggggag atatgtttta agtgaaatca tgtttatgtt ttaggtaggg 549900 atggttcttt acagcacctc acaacattca ccagataagc agtcacttaa tatcttgttt 549960 tttataggca cactagaaaa cctttatggt acttcactgc aactactctc cacagtcccc 550020 ctttggccca ccgtggtgct gacatctggc ataacggact atgtgttctc accagaattt 550080 tgggaaaagt tcagtcccac attgtattct cgattgcctt tacgaggtgc ctgttatttc 550140 tcactttatc tcctggtaga ggaaaaatca acatcgaata ctttgaccag ttcacatcca 550200 agatgaatac ttatatttga taattactat ttgaggcaca aatatatatt tgatctactt 550260 tttttttttt tttttttttt ttgagatgga gtttgactct tgttgcccag gctggagtgc 550320 aatggcatta tctcagctca ctgcaacctc cgcttcccgg gtccaagcaa ttctccagcc 550380 tccgcctcct gagtagctag gattacaggc atgcgccacc acacccagct aattttgtat 550440 ttttagtaga gatggggttt ctccgtgttg gtcagactgg tctcaaactc caggcctcag 550500 gtgatctgct tgcctcggac tcccaaagtg ttgggattac aggcatgagc caccgcgccc 550560 agcctgatct gttctttaaa tggtgattct gattcaattt tccattgagg gaatttctgt 550620 atatttttga taacacaatt aaaagcaaaa tattccatcc ctttgattta gtcaaacttc 550680 ctccctcgag gccagttttc cctagttcaa agggctttta cctgtgacaa aagctcattg 550740 atatgaatca gaaaattttt cagcactgaa attactccct taatttgtcc caaactgcca 550800 atagtgtttt tattgtccca tgtgtatgaa acagtcttca tattttaata ttcattaaaa 550860 tgattcagtt tcttagaatc atacctttac tcagtttctg gtctagtctt aattactggt 550920 gacatttctc tcttttcagt tcctcccaag tttgtggttc agccacggga ccaggacggg 550980 atttatggca aagcagtcat cctcaattgt tctgctgagg gttaccctgt acctaccatc 551040 gtgtggaaat tctctaaagg tatggagtta cttgatctac ttgttacctg tcaaacattt 551100 gctatgttct aaaggattag ataagcattt ctagatttcc agagaagttt cttgcaagta 551160 gatacgtatc tctgtttcca ccaagcctat cattctctca tagacattcc tagttgtcca 551220 cctaggtgtt tttattcaga cacacaacgt gtctgttgta cataacatgc ccttggaaag 551280 gccacagagg gatggaagtc ttttgtgtag attgtttcag cacttaggaa gtcctacctt 551340 gcccacctgt attacataac catggtctgc ttagagatca ctgcacactc gtacatgaag 551400 agatgtgagt ttaaattgtc agaactactc atagctggaa aactatttcc ccagtattta 551460 gagagatgag tgggtttaga aagttaaaga taatatcatt gattgtttta ttccccttat 551520 taccttagaa tatacagatt acacgtcatc tccttggcgt gctcttttta aaaacaaaca 551580 cgcccaatgt cctattgcga ttgtctcatg ttccctgctt gcacccctaa tcatgtttcc 551640 tcttctaatg cagaacagta gctcctgggt tttaggtgac attgtagata ttatgcaagt 551700 agaaatgtat gacatggaaa cgaagagtgg aatcatgtta gactttggaa aaacaatttc 551760 tgttcattag ggtggcttct tcagaacgcc tccttaacgg tacttgcaaa catattggaa 551820 gttctctttc ttttctcatt tagacacttg aattcagtac tatattagtt gagggccaga 551880 tatgtactgg tgagatcaaa taatcagtca atcatgacct tttttttttt ccaataacct 551940 aagacctagt atctaggttt aattattgtg aggtatttgt atttgtgttg acttaatcat 552000 catttatact ctagatcttt cttttttaaa atagcatgtt gcattttctc attatggaag 552060 caacaatgac caaaggaaaa ataaatggta catttgttgc aaccctcctg gcatctctct 552120 tttgagaagg aaggtaaaga agtggggaag gttgctagac actgtctgat tgggaaaata 552180 gctaaatttt taaaagtccc tgaagcaact cccctgtcac acaccacaca ccacatccac 552240 tgtccatgtg caaaggactt cttcaaaaat aaaatcctgt tattcagagt ctctgccccc 552300 atgacttttt atttcctgcc gtatttgaag ctccattgtg cattattaca tggaaacaga 552360 taaacatcat aaatttaatt tagtttctat ggaagtgcat atttgatatt atggacattt 552420 tccatgacat ttgccttctt caacattatt tttaatgcct gtcgttatgc aggtgttctc 552480 tctctccctg agggtgttta cagttttcac tctcataaac actccagcaa atgaacactc 552540 ctgtatgtta attcaatgcg catatgtgta agtgaagtga aaaggcacca gccatataca 552600 aggctcttac tctgtactgc ccaagggcac ttaggccacc aacagtatgg gtgggtaaat 552660 gtggcccagc atcctcacca actagataac atttttttta aatagtcttt acaacctgat 552720 ggttgaaaat gccctctcat tttaatttgc atacttagat tgttaatgtt gtttaacatg 552780 ttttatctta tgttaacaga ccacttctac ttctcctttg ggaaatttct tattcatgtt 552840 acttgcacgc ttatctctat gtcttattta tttggaagtg tttctacata gattaaataa 552900 tactttgtct gtcttggatg ttactgacat tttatccctt cttaccacta acttaaaaat 552960 taggttgtaa tagtagcttt tttgtcttta aatttcatat ccaatatcaa gtcatcaaag 553020 aaaaaaatta gaaattgcaa ttttttaaaa agttaaattc cccccaataa catcactcaa 553080 agatgatcaa agataactgc tgcaaacatt ttttgtctct agactgtcag tcctgtcccc 553140 aagcaattgc atacccatag atacacatta tacattttta aaagtttgat gattgttgct 553200 ggcttataat ctttcttcag tcaacaatat actatgtatg tcttgccata acaacaaata 553260 tggtgcttaa tatgactttt ttttttctgg agacagagtc ttgctctgtc gcccaggctg 553320 gagtgcagtg gtgcgatctc agctcactgc aacctccgcc tcctgggttc aagcaattct 553380 tctgcctcag cctcccaagt agtagctggg attacaggtg tacaccacca agcctggcta 553440 atttttttgt atttttagta gagatgaggt ttcaccatgt tggccaggct ggccttgaac 553500 tccgtgactt tttaatgtct gtgtaatgtt tattgtagta catcaataat tacgtttatc 553560 taattacttt agttaagatt gagttcagcc acttaaattc acaagggttt atttttctca 553620 taagaggact ctggatgtcg acagctcagg actagtttgt tggcttggct aagtcatcag 553680 gcacccaaac tccttatgtg ttaggaagag ttctgcctct cctagcagca ttcttcatcc 553740 tcaaacgatg gccaccaagc tatagtgtca acttcctttc acatttccct gtaggaggaa 553800 gagcaaaggg agatggctgc ccctcccaca cgactcacct ccctttaagg tcctttccag 553860 aagtgcatca cagatcaatt ttgccagcat ctctctggat cgctggccgg gtcgcccctg 553920 gctataaagg gtccgtaagc catcatggac ataatgtgtg ttattttcct aagtcagagg 553980 gggtgttgga tacctggcaa ctggatatct ccaacactat tgttgaatgt catatttttg 554040 gtttttgcca gtttttcttt tagaaaaata tcgtaatggg ccaagtgcag tggctcacac 554100 ctgtaatccc agcactttgg gaggccaagg caggcggatc atgaggtcag gagatcaaga 554160 ccatcctggc taacacggtg aaaccccgtc tctactaaaa atgcaaaaaa attagccacg 554220 cgtggtggcg gccacctgta gtcccagcta ctcaggaggc taagaatggc atgaacccgg 554280 gaggcggagc ttacagtgag ctgagatcac gccactgcac tccagcctgt gcaacagagc 554340 gagactccat ctcaaaaaaa aaaggaaaag aaagatatca taatgacttc taatgacttc 554400 tgtcacattt atctttgtat atgtgttcat ttatccctgg ggataaattt ctataagtag 554460 agttgctggc tcaaggagta aataattttt ataactttca atatgtattg acaatttgcc 554520 agcattttat tcatttacac aactcacctc agtttgcagt agtgtctgtc tcttataacc 554580 aaaataatac tggatattag gctttttttt tttgacattt tccaatctga tagagaaata 554640 tggtatattg ttattttaat tatgcaagca gtaaatctat ttcttaagaa caatttagcc 554700 ttgcttatgg aacatgtttt ctttcaatga aatgatcact aagagctgaa gtgcagctcc 554760 ctcataaatg acaaaactgt ataaacaaaa cagattcagc ttgtttcctt gagagatgca 554820 acagtttaat tcaggggagg cagaattcca gggtaaatca ctgcagttta aaggtagcta 554880 ttgtagaaat gaaacaatct ttgctacaaa aaaaaaaaaa aaaaaaaagt cattacattt 554940 ttgaccttgg gtctagatac acaaagtctg agacattcag ttctcttttt tgatttattt 555000 atttacatga acaaatgagg cctcttgcct aaaagagatt taaaaaaaaa aaatcagggc 555060 ttcattctga ggtgggtctc acctgtactc ccagaagtcc acagcttaat gccattctct 555120 tgcatgtatg tcacttatac tggagggaaa atagttcagg gccatctcct tgttacctgc 555180 tgagaagcga agagggactg caaatgcgag agaatagatg atgcatcagc ctggggcctg 555240 gcctgggcct cctttgctct ctctggctgt ccatagagtc tctgaccttc agggaaactt 555300 ggttgtggga atgtccaaaa agaagagtca gagcatgcct ggggggtgac gctggaggac 555360 aatggggagt agtttgcatt taaaatagca ttgtcaaaat accccaggag tagggaaagt 555420 ctgaggaaag acttaaagac agatgagtcc tgtgctcctg tcctccgagg gagaccggaa 555480 ggtgaggggc cagctagttc ccaagagttg ggggtagggg gcgaggccgg gaggttgatg 555540 cctggaatga tccagaaaca ccaaggagga cattacagct gtggcagagt tagtgaaagg 555600 aagtcctggg agaggagact cctgcactgg gtccccatca gtcattgtaa ggacctggct 555660 ctgcccaagt ggggagtggg tatggtgagc aatgagagtg gtgatggtga tgcggtctct 555720 tcagctgctg ctgtgctgaa gccagaagct aggaggctag ctgggtaatt ggagagagat 555780 ggtgtgatct gcctcatgct ttaaaaggat cacactggca tgctgttttg aaagcagact 555840 gtgtgaagga caggaatttc agccggagag ctgttctaag gccttggccg ggatgtggcc 555900 ggaaccaggg tgactgcagt ggaggaggga caaatggatt ctgaatgtct ttgagtgatg 555960 gacatactat gggtgtgaca aaaggggaga accccaggca gtgaggatag tggaagtgcc 556020 ggtgacagac aggacgactc caggagggca gacctgtggc tggggtaaga tcagggtttt 556080 gggctcctct ctatgcagat acagctgtca atttccaata taagcaatga taaattttct 556140 aaatatccta gattttgatg aatattttct gcattgtcag agcttagacc ctctatgttc 556200 tgttctgcag ccatatgccc aacttttgca attgccagtt ctgtgttaga ttgattttgt 556260 gctcagtatg agttatttgg acatagtgaa gaatattcca acctctttct ggtttgcaat 556320 ggtttgttcc ttgccttttt acacccaaag gacagatatt ggcggctcac actgtctcct 556380 tggagggagc acagactgcc tgatttccct gtagaaggaa cttaatcttt ttggttctgt 556440 gcaccaaaga gctgactttg aagtctggta gtttattttc tttttttatt tttgtgatgg 556500 agtctcgctc tgttgcccag gctggagtgc agtggcacga tcttggctcg ctgcaacctc 556560 cacctcccgg gttcaagaga ttcttctgcc tcagcctccc aagcagctgg gactatagcc 556620 atgcactacc atgcccagct aatttttgta ttttgggtag agatggggtt tcaccatatt 556680 ggccaggctg gtcttgaact cctgacctcg tgatccaccc aactcggtct cccaaagtgc 556740 tgggattaca gacgtgagcc accgcacctg ccctgaagtc tggtaaattt ttagtctata 556800 atttggtgtt ttccatttgg ggtcaatttt cccatagatg tggtgcatct atttaatatg 556860 tagattcagg ttattttaaa aaatattttt cccatgaatt gtatctctaa gtgttctctt 556920 ccctgcttta attttcttct tcagggtctc tgattgtggt tccataggat tgccacctag 556980 tctctgtagc tgtcattttc tctctggttt tttaactcat tgatttccat tttaatttgt 557040 tcgatatttt tccatttctg ttctccatgt cttttcccca gcaaggtctg ttcttctttg 557100 tgccaactcc ggttctgcct tcactgctgt gagtttatat tttttctcct tctttctctc 557160 cagctctgcc agctcacagt tcacccttct tcagccatgg ctttatagac aagtgactgt 557220 tttattcaca gtcttcatct aagtcgtaat acctggtttc ttgttctgtt tttttcttct 557280 attttgctta ttgtatcttt gctaggtctt ggtttccttt cgaatacagc agccccaaga 557340 cccccagggg atgactgaac cttggggagc accaaaccct acatatacta tgcgctttcc 557400 tacacatgca tacccctgat aaagtttaat ttataaatca ggcacagtaa gagattgaca 557460 aaaattatga gtactagaat aaaattatta ttacaatgta ctgtaataaa agctatgtga 557520 atgtgctgtc tctgtctctc tcaacatatc ttatgtgtct atactcccct attttaagac 557580 tgtaattgac ctcaggtagc ttaaaccatg gaaagtgaaa atgtggatga gggggaacta 557640 ctgtacttac atttgaagaa aatccatgtc cccagaaaaa gattgttgtg tacaaatgcc 557700 tgattcctca gctaacccta cttctaaaat tctaagccac atcaggcctg gggaagtgcc 557760 acccacaccc acctatgcac actgttttca ctgatggagg cttggctctc acctgtgacc 557820 cactctgctg ggacttctga agttcacagc ggtggccctg attccctcat cttcctgcat 557880 gctcttctgc tcaattaccc tgttggttgc ccatttaccc attctgtagc tggaagttta 557940 gctattttct aatttcatag gaaatagagg ttacattttt ctaggcttct ctctcccatt 558000 tgctttcatg ttgttcccag gaagagaaga agtgctggtt tatgcctcca tcttcaaata 558060 tgaaattcta ttgtttatat acaaagggtc attaaatttg gacttgattt tagtaaaata 558120 aataaagtag gaatctagga ggaggagtag aaatcatcag ttaggagact gggctataag 558180 ttcaaacccc agccataata caaccctgtc tggttgggtg actgcatgta aattacctac 558240 cccatatgaa ccacagcatc cttgcagctg aaacagataa aataagggga taaatgtgat 558300 gatttagtaa gatgactcat agaaagcatt tattatggct tctggcacat agccattagt 558360 cagtatgtat tagctattat taatatcatt attgccatta tcatgaactt acatggttag 558420 ccatttgtcc taaaaccatt tattgaagag cccaaacttt ttcatttgcg ataccttatt 558480 gtctaagggg aaaatgtgaa tactggagtc tgtgtttcag ccttctctct gttacactca 558540 attgcctgtt cagcaccata cgtattagaa gtttatctcc ttctatttta atgtctgttt 558600 tgacaatact ccccttgtga cttttatttt tcaaaaatgt ccttgctttt tctgcatgga 558660 tttttgtttg tttgttcctt ctagatgcat attaagataa ctttatcaag tttccaaaaa 558720 atctggaaaa tttggaggat cataaattta aagcttaacg tgaagaatgc tgatgtcatt 558780 agaatattga gtcttcccag ccaataccat ggatagtcct ttcatgtatc caagtttttc 558840 ttttatgaac attaataatt ttattgcatt ctttccattt gtcagtggta gtgaattttt 558900 ataagctacg gcatctggtt ttcttttgtc ctccttggtt ttctgggcgg aaaggggtca 558960 agagctgtct acagccaatc tttgttgagc ttgtccttat gtagctgtcc acatctcttt 559020 cttctcccag caagggtaat gctgttctta atttagagga gtttctattt tccccactct 559080 gtagctcata ctaagggctg caatggtgtg tgactctatt tcttcctgtc tctcttgaga 559140 ttgtatttct ccctgcccct tttcctgtgt cctttctgct cattgtagtt tccccaattc 559200 catatttccc tggaggctcc agagaatcca ccattatttg gtgcacacac aggtttgctt 559260 tagctcctcc ttctcctact gcacccagac aagctgctgg aggctgtcac ttctgcactc 559320 accacgcaca gtcccccaga gggcctggct gtcccttacc actagggccc taaaagcacc 559380 ctcttctgct cagtgtcagc ccacctggag aaatcctccc ctgtggttat agactcatca 559440 cagggggcaa caggaacttg attcttttgt tgagagattc atagaaataa aactaggcac 559500 tccagacagt taactaaacg tttccatgca agatggaggg gaaaacacat gctgtgctca 559560 atactggcca aactgctcag gtgaccctct ctggagtccc ctcctacttt aggggcatgc 559620 cctggaaagg ctcaccttga tcctgcccac aacttccctc ccaatgtcca ggggacatcc 559680 ctggaacctt ctgtagtcct catggcctat gtctcagaag accatgagaa atatgaggga 559740 aaggacaagc ctaagtccct caagcaggtt aattctagag cagattttct gccaacacca 559800 gtttcagacc tctctggtga gatgaccaag tcagtccctt cctcagcagt caagagaggg 559860 ctcacactgc agatcacctg ttaatcacac tgtgatcaca ctgcacatca tactgcagat 559920 cacactgcag aagaccctgc agatcacact gtggatcaca ctgtggatca tgctgcagat 559980 catgctgcag accaccttga gatcacactg tggatcatac cgtggatgac attgcagatc 560040 acctgcagat cacactgcag atcacactgt gatcacactg cagatcacac cgcagatacc 560100 tgcagatcat actgcagatc acactgtgga tcacactgca atcacactgc agatcacacc 560160 atggatcaca ctgcagatca caacgtggat catactgcag atcatgcttc agatccacct 560220 gtggatcaca ctgcagatca caccttggat cacactgcag atacctgcag atcatactgc 560280 agatcacacc atggatcaca ctgcagatac ctgcagatca tactgcagat cacgcttcag 560340 atccacctgt ggatcacact gcagatcaca ccatggatca cactgtggat cacactgcag 560400 atgacactgc agatcacact gaggatcacc tgtggatcac actgctgaac acactgcagg 560460 ttgtacattc aaaagataag tctggaaaga agcaaattat caagagacag aaatttgctt 560520 aaataaaatt ctcttttgtt tttcctctgg gaaagcaggg ggtttatatt aaaatagctc 560580 aatagggagc acgttcatag ggcccagttg ggatgatact gagttttcag gtcctccaag 560640 gcttctcccc aagttctggt ccctttgtcc tgctctgtat gcccttgcat gtttcactct 560700 gcgccagcct cgtgcctgag tgcccccagg ttcagtgtcc aaggcatttc gtctcattct 560760 ttttttgccc ttgctgccac tcactctgac cttgaatgcc agttccacag gctttgctca 560820 gacaagtgtc tcttttgcat ccctgttctg agaaattggg tctctgcatt gtctctgacc 560880 cttgtcttgg tcatctcctt gggaccagtg gctccaatcc tggccctatc ttaatcctct 560940 tagtgtggat caccagaata aaacttctga ccacaagcct gacctggtgg aggctgctgc 561000 cctcccactg tcccacccct gcctgtgcat ctgcacacta ttcagtgctc tcaccatgcc 561060 cattcctaga ctcaccattt gtcttgctct gtgttgttta gagcacccca agactccaca 561120 cccatggttt tgacctcttc catgtccttc atttcctgaa gcagcagtga tcccctgctc 561180 tgccccagtg cactcctctg atccaggcta tcaagtcctg gctctcaccc agcaccccga 561240 tttccaatta ggtgataaga tgcaaatatt gaattaatat ggggaaagaa ttcaaataat 561300 ccaaaaacga gaagaaggca acatctctct atggcacaca tggtaaaaat aaacccaagt 561360 tcaaagtccg atatggatcc ctcatgcaca acaaaaggag ctctgcttgt gtgttgtgtg 561420 ttccccaaga agagacaagg ggcctcacaa agaaataatg agttcttgaa aacaagttgt 561480 aagctgaaca gagaaagtga gtgttccata tattgtttta ttttcttcct ttgatggtag 561540 gaaaaacctt agcagagcag aaaacctgcc ttcctctgtg ctaccctaat cagcatctca 561600 gtggccctgg gagctgctgc aggacctctg cagggtcctc acctaaggaa gtgtaattac 561660 cctgagcctt ggtggagcca ccaggacagt caaccctggg gcccatcttg ctcttccttt 561720 ctttattttt cagcactcct ccatctttcc ccctcattta tttcctggga aactttctgg 561780 aagccttctt ctaggtgtag gcagtcacac tgaagacaaa tgtttggggg gctcttgctc 561840 cagggaaacg gtggctggag accttgaatg gtagacactg ctgcagggct cctcccagga 561900 gcaaggcaaa gcactggtgg aatctgcata attgagtcac ctcaaccact tccaatatca 561960 catgacccct tgacgagtgc tgaattgtgt tcagttcatg gatcaattat ctgataagtg 562020 agtgaagggc caattccctc tggctgattt aaaaaaaaag gattcttatg tattagttac 562080 ataattacgt attagttaca gaattagaca ttgaagtgct agtggactag caagttgtaa 562140 caaatcctga ttagacacta atctagacca tgaaatttcc attgttgtca ttggatagcc 562200 ttcttcaaca tagaaatgaa ggtattaagg aaagatgact ggattgcaca gtggacacaa 562260 ttatgtgcac atttacaaaa gaagtaacct ggacggtgtc acacctggat ggtgtggtgt 562320 gttatcaaga agggatttaa taaagggaat taggggcatg caaaatcctt tgaagcgtgg 562380 acaaactgcg cggcccttta agcacctgag aagtgtagga actaagatgc ttctcccgtc 562440 actgctaaca gctgcttcta gtgctcaagc agtgatttgt agttctccca caggcagcca 562500 taaacctgat gtttggggtt gacccatgca tcaatttgct gcttctaaag caaaataatg 562560 gcttttccac ccttgcacct acaaaattgt ttttaagtgc ctctcactgg taaaatgtaa 562620 accagaatct agtaacaaag ccagggaatg tagttttcag gctttcaagc cctgcaattt 562680 agggcagagt ttagagggaa agtggtagtg ctaaagatca acatacagca tctgacacaa 562740 actttcagtg tcataaatat tacctgcaca gtggtggaag cttctttctc agggattgga 562800 aatagctctc cagcctggaa ccaagccagt ggtgtctcag gactatacct ctgtccactt 562860 cgggattctt ctttgtaaca gaactcttca gcactccttc actgaataag cattgtattt 562920 cagctactaa accttattta ggtgcaactg ctgttgctat tcttgctttt tctcttatct 562980 ttccattgca acctctatct ttttacccaa tgctttcctg caatccccca actattctca 563040 gagaggaaac cccccttcct aaagaagaaa aacaaatgca ttcttgagga aaacaccact 563100 ctctccataa ggatgaaagg gattgtgttt gattccttgg tgaaaagaaa gaacagctta 563160 ccgcctgacc attgtgcaaa ccattggtga ggctaaagag acctcctttc catggtcctg 563220 cgactcttca gtcttatttc accctacaag gggacccctc tggatgagct cattgaccaa 563280 gctctccttg catgcaggca tttataccca cattcataca atcttgcttc actttatgtg 563340 cacaacaatc ctacatcata tgtaaatgga ttattctcct tattcatata tgatgaaatt 563400 aaggatgcag agaaaataag ccacttgctg taaggcatgg gtagtttcag agagcatgag 563460 aacctaaccc ttttgactct tatccaagtg ccctctctac agaccagcaa agacttaaca 563520 gtgaaggaaa aaaattgaaa caattttctt atttgctgct gccttcaaag tgggctcatt 563580 tggtgacaat ctgccgttct ttttccactg tccccatact ctcagtccct gtgaacacag 563640 ctatgcatat atttgcaata aataagaaag gtgacccaga attaatataa ctagcaattc 563700 agtatgtgcc ttacataatg ctttaacatt ttattttcat gtaacggagc attgaaattg 563760 tccccacttg acccctgcta gccacagaaa attggcagtg ttttaattaa tgactgctgg 563820 ttaccacatt gtatcttcta gctaattacc taaagtgctt accttgtgct aagaagatta 563880 caggatttta catattgatg ctttgggtta aattttactc tttagaataa agatgaatct 563940 aaagtagatg actgataaat aattctgtca aaccctggcg aagtctactt ccctccaatt 564000 aaacaaatgc tagcccttgg aactgtagtc ctcatagtag atgaatcagt tggcagtgtg 564060 ttcactatta ttccatttag taaccacaat tagatcttca gatgcaataa cccttcaact 564120 taggttcatt tttctgatga agaaaagatt taatgttttc ttaaatgcat ttgaaacttt 564180 atttctatct tcattaggac cttttagtaa taaagaaact tacttcagtc tagataggaa 564240 taaacagatc atccttttct gctatttaat tgagacgact tagcattgta gttaatttta 564300 tgttgtgatt ctttaatata aatgtttcaa caattacaag catttttctg gtgaaaatta 564360 tttaagaaaa ggaaaacaat gtgttgttga catggatatt catgtaaatt tttcaaacca 564420 caccagcatg ttatttgatt ttcagtttct taaatacagt tttatataat ttgaaatttt 564480 tagattacct atcttttttt tttttttttt tttttttttt tttgagacag agtctcgctc 564540 tttcgcccag gctggactgc agtggcgctg tcttggctca ctgcaagctc tgcctcccgg 564600 gttcaggcca ttctcctgcc tcagcctccc tagtagctgg gactacaggc gcccgctacc 564660 acgcccggct aatttttttt ttgtattttt agtagagacg gggtttcacc gtgttagcta 564720 ggatggtctc gacctcctga cctcgtgatc cacccgcctc ggcctcccaa agtgctggga 564780 ttacaggcgt gagccaccgc gcccggccta gattacctat cttatagtta tattttttca 564840 atcctatatt tggttgagtt ttcaggttgt gtgtattgga ctaaatctat tctcaattta 564900 cagtcaactt tgggaacgac attaatagcc tttactgatt ttcaaagtgt gttacaaatt 564960 taagcactta aataaaagtt gaaggctttt tccttaattt taacttccaa taaatctatt 565020 atcctcacac taatgaacac aatatccaca agaagtaatt tgataattta taaaagccaa 565080 attctttaaa aatgcagtct aattttatag gagaaaaaaa tgattatctc aatatatggt 565140 taaaaactag ctgataatat tcaacatcct cttctgattg aagcaacgag aacaaaaaaa 565200 gagttttgta aaataattac atagaaacac ttccttataa cccaaagtgc tttggaaaat 565260 gaagaaaaag acaaaagctc agtagaaaaa tgggtaaggg ataaatgggc tgtttactaa 565320 agaacaaata cagatggcca atacattcat gatgctcaaa attatctata aacagaaaca 565380 aacaaaaata caaaaaaaat ccgccaaaat gtgcaaatta aaatagtgat gtatagcatt 565440 gatgcagatt taaaagttta atagcataca tgtatgagga aaaaattaac cctcagctag 565500 cactgaagga gataacgttt gtacattttt aaggcagttt attgtaaata tggtaatata 565560 ttttaagatt tgaatatgca tcacctttgg tccgaaattc ttctccctga attaagcata 565620 cagattgcct accgctatat atatatattt ctctccactg atgcactgat tgatgagtgg 565680 agacattcat tgcaacgtgg tccctattct tgtggaatgg gaaagacaga cagccatata 565740 atcttaaaat tattaaataa ttaaaaagag aatgttagaa agcacaacaa tgttgtttgc 565800 ttactataag ccataccaat acatagttca agaacttcag tgcttctacc atcccataat 565860 gaaggttcta ttattatttc cattttacaa gttaagaagc tgaaatatta tgtaacttac 565920 ctaattttac acgttaggaa tctattgctt tgtaacaaat taccccaatt tagtggctta 565980 agatagtata catttaatag cttccatttc tgtaggtctg gaatgcatgt gtggcttagc 566040 tgagacctct ggttcaccat cttcccaaca ttgcagccaa ggggttggct gggatgcagt 566100 catttcaaag cttagctgtg ggagggtctt ctcccaagct cactcctgtg atggttgata 566160 agctttactt tctcagactg ttgactgaag accaactccc agttccttcc catgggagcc 566220 tctccacaga gcagctcaca acatggtagc tggaattccc cagagttaag actgagcggg 566280 agggagagag ggaagaagaa aaagagatgg cagtcatgat ctttttagcc atagctcctc 566340 acccagtatt tgtcacagta caggtgctca gtaattaata aagtccattt gcataaaaac 566400 gaaggctaca ttattttatg tttagaagat attagaaagt ccgtaatctc tctgaaggta 566460 tttacttttt tactgtttga atttttgaca aaaaattcag attccctaat ccaaaattct 566520 catgctttaa atcccaataa gtaaactagt aaatagcttt cattaattat ttttcaaaat 566580 caaccactct tatactgatg tatttatttt ttctcaagca tttgaggcca agaacaatgg 566640 ctcgtgccta ttttcccaac actttgggag gctaaggtgg aaggatcaat tgtggccaag 566700 agtttcagac agtctgagca accaagcaag accccatctt tacaaaaaat ttttaaaggc 566760 ctagcggggt atggtggtgt ctgccggtat tatagtccca gctacttggg aggctgaggg 566820 gggaggattg cttgaacccg ggagttcgag gccacagcga gctatgatgg tgtcactgcc 566880 ctccaacctg ggcaaaagag caagaccctg tctcaaaaaa aaaaaaaaaa aaggcaccaa 566940 aatctgctgt gaactttcat atgaattaag gttttttttt taattattat actttaagtt 567000 ctgggataca tgtgcagaac gtgtaggttt gttacatagg tataaatgtg ccacggtggt 567060 ttgctgcacc catcaaccta tcatgtaggt tttaagccct ggatgcatta ggtatttgtc 567120 ctaatgctct tactcccctt gcccccaccc cctcacaggc cccagtatgt gatgttccct 567180 tccctgtgtc catgtgttct cattgttcaa ttcctactta tgagtgagaa catgaggtgt 567240 ttggttttct gttcctgtgt tagtttgctg agaatgatga tttccagttt catccatttt 567300 ccagtttcat ctattttatg gctgcatagt attccgtgaa gcatgtgtgc cacattttct 567360 tgatcaagtc tatcattgat gggcatttgg attggttcca agtctttgct gttgtgaata 567420 gtgctgcagt aaacatatgt gtgcatgtgt cttcatagta aaatgattta taatcccttg 567480 ggtatatacc cagtaatggg attgctgggt caaatggtat ttctagttct agatccttga 567540 ggaattgcca cactgtcttc cacagtggtc aaactaattt acactcccac taacagtgtg 567600 aaagccttcc tatttctcca catcctctcc agcatctgtt gtttcctgac tttttaatga 567660 tcaccattgt gactggcatg agatggtatc acattgtggt tttgatttgc atttctctaa 567720 tgacaagtga tgatgagctt tttttcatat gtttcttggc cacataaaag tctcatatga 567780 attaagtttt aaattatcta cattatacaa gttgctggtg taattctgaa ttttgtacat 567840 tttgataact tatttccaag gagggagcag atttagggat aaaaatggtt gtccttttag 567900 tctcacttta taaaatactc attagctcaa gtgaggaaaa catattgaag agataataaa 567960 atactgttat gtttttaaat gtttttatcc ctgactttga attccttatg aaaagaagaa 568020 ttttaaaaac tttttctact tagaatcatt ttatgaaaat tcatatttta gatatgtaat 568080 aaagaactaa tgcaaacatg tgagttttgt tagtagatgt tccctcttct aaatgtacaa 568140 ttatcctaca tttacatttc tcttaattac ctttaaaaca gatatcagaa aactatgggc 568200 cacaattcaa atttggccca catcctgttt ttgtttttgt aaataagttt tttagactat 568260 cttatttcct cataatgatc accaacattt atcactatat gctaggacaa agatcaattc 568320 ttctcagatt cagtattttt gaagactcct cctcctcctc ttcctcctcc tcctccttct 568380 cttcctcctc ttccacttgt tttagagaca agatctcact gtcacccagg ctagagtaca 568440 gtggagctca ctgtaacctc aaacccacct cagcctccca gagcattggg agtagctaag 568500 actacaggca tgacccaaca tgtccagcta atttttaaaa ttttatagaa atgagggctc 568560 actctgtgac tctggctagt ctcaaactcc tggtctcaag tcttgccccc accctggtct 568620 ccgagagtgc tgggattaca ggtgtgagct gtcatggcct gccaataagt tgttatgaaa 568680 cacaatcatg ctattttgtt tctgtatttt ctatggctac tttcatgact cagtggcaga 568740 gatgagtatt tgtgacaaag actgtatgac ctgctaaatt taaaatattt actctctggc 568800 ctttacagaa agattaccaa cctctttctg aaaatgttaa gcatttttat tcatgaacat 568860 ggtataactc tctaattatt taggtcttat ttagttattc tcaacaactt ttacaatttt 568920 cagtgggctg gtcttgcaca tattttgtta aatttattct aaatatttta tggttttttg 568980 ccaatatatt ttctttttaa tttttattcc caattggttg ttactattat acataaataa 569040 aattgacatt gatttttgta tattgatgtt gtatcccatg actttgctaa actcatttta 569100 tagttatagc aacttttttg tttactcttt tcaattatct atgtagaaaa tcatgttatc 569160 tgtcagtaaa tacagttata ttcttatcaa tctacattcg tgtactttta ttttcttctt 569220 attatttttc tttttttttt tttttgagac gaagtctcac tctgtcgccc aggctggagt 569280 gcagcgccgt gatctcagct cattgcatcc tctgcctccc aggttcaagc agttctctgc 569340 ctcagcctct caagtagctg ggattagcag gagaatcact tgaacccagg aggcggaagt 569400 tgcagtgagc cgaaatcgtg ccactgcact ccagcctggg tgagagagca agactacatc 569460 tcaaaaaaaa aaaaaaaaaa attcaggttg tcgtatgtcc cctctagcag ttccattttg 569520 atgggaacca cctgttgtgg ggattctact tgatctcctc attcaatgtg aaaggtcccc 569580 ttaggtacct tatcaatttc tctcgtctct tcagtggggc tagagacaag ttgctgagaa 569640 atctaaacca gaaacacggg aaaggaaggc acagccacag tctctgccat tgtgagctcg 569700 agtgagacca atacacaagt tgtcattagg gtatggagac agcaagagga agtgtctccc 569760 attctcctgt cctcagatgc aaagtctgaa gtttcctgct tgaggcctgt ggagacgtct 569820 gacttgttca gctcccgtgt aggttcttgg gccaggaagc tagcaccttc tctctagaac 569880 acatctttgg cccaaacgtt gagcttcctc caggaagatc ctcaccccag agctttcccc 569940 tcaagtcccc agatactcag gccagagaag aaaaatgccc tgggagagtc tttcaaggcc 570000 tgaatcccat tctcccagcc cacccaactc ctccaggcca gaagcaggca gcatggcagg 570060 ttcatccagt caccatcttc ccagaagtct tctaggacct tcataatctg tttcattatt 570120 tctaaaatcc tttttttttt tacccagttg tatataaatc cttcatatga atcataccac 570180 attcattata atagcatatc atatctgtgc cattccctcc ttgcatggaa gcactctgag 570240 gagagaggtg ttttaattct gtgctgtctt actgcactaa tctgatgtat ttatttaaat 570300 aacattaaat gatattaatg gtgtattgtg tgtctagacc ggaatataac caccgttaaa 570360 gagaaacctg caatattcct attctctttg tagcctcaga catgtgcagt gagcaaagac 570420 ttcaaatgcc atgtccctgg agcactcctt gtttacattc atattaagtc cctgggaaca 570480 caaggaattt atttagcacc atgagagttg tctgcttctg tggttgttct actgtgattt 570540 ctttgaataa tttatcagct acttaacact catcaaattt ggctttttat gtagagaaac 570600 tatctgtaag ttctgttagt ttttatctca gagtctgaga tactgtcatt ttaaataaat 570660 gcttttctct ctaaacaaga attttaatac tggaggaaag aaagaaaaac ctggtgtatc 570720 ccgtgactgc cttatgggat cagtgtgaag catctcttta tgagtctgtg tgtacttgaa 570780 ctcgttgtct tcccatactt actctcgttt gcatcattgc tcgtctttct ttttctgtct 570840 caggtgctgg ggttccccag ttccagccaa ttgccctaaa tggccgaatc caagttctca 570900 gcaatgggtc gttgctgatc aagcatgtcg tggaggaaga cagtggctac tacctctgca 570960 aggtcagcaa cgatgtgggc gcagacgtca gcaagtccat gtacctcacg gttaaaagta 571020 agagagaaga aatgcttcgt tttacctagt ttaaatacat aggtctctgg gggcttcctt 571080 tttcaattgt ctccatacat acctgtttaa aagcaacaca aaagaagacc cgttggtgtg 571140 atatagctgg gtttaaagtt ttgttgttct ggaaacatga ttgaagagga tggtaaacat 571200 ccagctaatt gttgacagtg tgcccagggc cccttgtgtg tggagcatga gccacattct 571260 tctcttcctt tggttctcac agccattggt atgggctctg ggcaacctag cagatgagta 571320 ggtctctgcc tttaacaccc acattgctac cctgttgatt ttcccgtgga aaaactcaat 571380 acatggtctc agatgtgctc tttacaaagc cttttgtcat gcattttgtt atttgcaagc 571440 tgtcttgtcc atggatttcc ttttaaggat cattttaaaa tcaagtgact agcgaacaac 571500 tacaagacag aaatgtgtaa gactaggctt aatgctggcg ctgctggccc aatatataga 571560 aaaaggtgcg ttataatgaa attattctca tacattggta actggcaacc aaggaaagga 571620 tataaagtga accagtttta ctgagttgtg cttattaaca aaatgatggt gcatctagtt 571680 tacagtgaat ggcttatgcc catttatgga attttccatc gaatgaactg tgatttcttc 571740 ttgattacaa ggctttattc agactcccct cccacttttt ttttgaggca gaggctcact 571800 ctgttgccca ggctagagtg cagtggtgcc atcaaagctc actacaccct cgaactcctg 571860 agctcaaggg attctcccac ctcagctttc ttagtagcta agactaccag tgtatgccac 571920 tgagcccagc tttttttttt tttaattttt tataaagatg agggtctcac tttgttaccc 571980 aggctggtct caagctcctt ccctcaagtg atcctcccct cttggcctcc caaagcactg 572040 ggattacagg cataagccac tatgcctggc ccttggattt cctctttttt ttaactttaa 572100 ttctgctatg gatagtttgg aaaagtctct actatatgat ttattagaag aatgagattt 572160 aaaagtggca ttcaggggtg tgtgtatttg tgtgtgtatg atattgaaag gctagctaaa 572220 cagacaagta tccatcctaa ctcacgaaga atttatttta gttagtccac tatttccaac 572280 agaacaaaaa aaatccaagt gtttatttat taaagtttta tattgtgaaa tggattataa 572340 ttatgaaatg gggttgtttt ggaatatatt ttgcacatac tcaataccta gtttttgact 572400 tttaaatcgt atgctctgga ggaaatgatg tgcaagaatt tgataacgaa ttgtggtact 572460 gtttaaatcc agagctgaaa tggtaatttt taaaagttat aaaggaaacc taaaatctga 572520 ggagcaatgt tgaccagagt cggtccatct ttccccaagg aaaggggtgt attttgcagt 572580 tattttaata gactttaaat gcataagaca attttttagt ccataaacac atatctagga 572640 cccaatatat ataagaccct atgaaggata caagtacaat caaccatggg ccttaccctc 572700 atgagtgaca agcctcatgt tttggaaggg gagataacca ggaagaagat agaagccact 572760 gattacaatg cagggtgaag agtcacatgg atcatgtctg tgacattcag aggaggatgg 572820 aaatgtcagc ttgggggaat taaggaaagc ttcatggaaa ataggcttca agaatggacg 572880 atgcccccat atgtcctctc tccagatctc ggtactcagt ggcagttgtg cagcatcagg 572940 gaggactaag gagatgaggt ggcccctgcc ctctaggagc ttttgctctc tggggataat 573000 tgagtggata tatgtccaat tcctgtctgg cagaatacac aactggtgga acagagccca 573060 gaacaccagg gttcatggaa gagggtatga tttgcttctg tttgtagaat cagtgaccgt 573120 gtggaatgaa ctgaatgtct gtgtcccttc aaagtccata tgttgaaatc ttaccgccag 573180 tgtgatgata ctagaatctg aggcctttga aaagtgattg ggtcacaaag ggggagccct 573240 cagggatgga attagtgtcc ttatcgaagg gaccccagag agctctcctg ttctctgttt 573300 ccaccatgcg aggatataca agaaggtggc aacctggagg aggatgctag aacctgcccc 573360 tgctggcagc cccatctcag acttccagcc ttagaactgt gaggaataca tttccgttgt 573420 tgataagcca ccaatgtatg gcactttgtt acagcagccc cagttgacta agaaactacg 573480 gaacgaaaag ctgcagcatc tgagttcggt cttaaagaca caagggcctt caaaaggcag 573540 gactgttgag gctagatagg gtattccagg gacaggagac agagaagcca gatacaagaa 573600 actgaaagac tccaggcaag agtaactctc tgttcgaatg ttctacagta catggaggag 573660 atgggagagg agaacattta aagtgaacac acttcaaaga gagatgatag agttggccaa 573720 attttagatt cttaaactaa tacaagctag tcatggacag gtggatttaa ataagttaaa 573780 tgcacctctt catgactgtt tgtattagtt tatctctcta ggcctagaaa ataggaagaa 573840 ctatgccatc ttcatagagt tatcatgaaa attaaacagg gtaacacatg tgaaaacaca 573900 ttgtaagaca taagatactc taaataagta ttccaataca tacatagagt aaatgattct 573960 ttggttggaa agaaagagaa aatgtatatt gatggcacag tgcataggag catttccaga 574020 aagttattct gaaaaaaaat taaaaggcca gaggctagga aaagggaaga agaaagagga 574080 cctccatggc ccatggggag gtattttcat ccttgtctaa tactcgtcca aagctcagcc 574140 ctggagtggt gtctttagca actctaatgg ccaatgtctt ttgcctaacc ctagttgttt 574200 aagaacaatc agtaaagtgt tttaggatct caaactgaaa aaaaaaatag atataaagga 574260 gagtttactg gtctaaataa acacattaag tactctcccc tttctgtaag tcattttaaa 574320 aaatgggctg caaatatttc taaattcaat aggggagacc ttgctgtcta attggatgat 574380 gtcaggaaat taagacagct gctcctgcag caagtctgga ctcccaggat ggcctggtgc 574440 tggctgtaaa cataatttaa agacccaaac tctccggata ggacctgctt ctgggggctc 574500 actgtgagat cctgcgaacc ctgcacagag ggtttctcct atatgggaaa ttttcttact 574560 gctttcaaga aacatcactc caaaaataaa gcattttaac aataaacacc caccacatac 574620 acacacatct ttttgttgtt gttattgaat caagcataag gaagccacag gcaaagaaga 574680 aagccagcaa gcatgtatgg aattgtcatg gaaagcaatc aatgggatgg aaggttactg 574740 catgcaaatc tttccagctc tgttggggtt cctgtctgtg agtctacact gtcatcacaa 574800 ttctggttta tgttttaccc aaaataatta tcatgtgaga taacgattag gaggcttggc 574860 agaaaaggca gagggagtag gctctgcttg caatcaaatt tggcctctgg tgatgacatc 574920 ctgccctatg ctccaggccg atcgggggct acagaagcta tgccacttat gtgccccttc 574980 ccccaaccag gaactgtttg aggcccaggg aatgacttta tgttaaaaaa aaaaaaaata 575040 gctctgtcaa tcgaggaaaa taatgagaca agtctcaatc attttaggat atttatttgc 575100 caaagttgag gatgctccca ggagacaggt ctattccttt ctccgaaggt gattttgagg 575160 gctccaaatt taaaggggaa aggatgagat attgagaagc acacagcttt cacataaaca 575220 aaaggggcag aggaaaactg tggggaatgt gcattttaca taccacagac aaaatggaga 575280 ggggaacgtt cagttataca tttgtgtctg gtgggcagag cgactgcacc tgtaaagata 575340 ggctatcaag ttgcattgcc atggggaagc tttaacagct caccaggaat ttccttgtgg 575400 gcaaaatatg agggaagcgt gtagcttttc atcttgtagc catcttgttt aggaaccaaa 575460 aggtggaggc agatttgcgt gacccagttc ccagcttgac ttttctcttt ggctaaacga 575520 atttggggtc ccaaaattta atttcctttc acagctccaa aacccactga atctcttaaa 575580 tggatagcca tccctaaggt ttgtctcaga tgcccaaatt acatcctccc cgctcccaac 575640 tttctgccac tggctgatct gaagcctcgt gtttccggga acactggttt cagcgtgaac 575700 ctgtggccca cagtgaacaa gccgctctgc ttttgtgagc tgctctgcat aggtcctttc 575760 tgatccctgc atgcaggaca aaagagcacc gcttatcaaa caggaacagg cgcttccctg 575820 gagagtcagt tactcttgga atctagtgaa cccccaagct cccaaagtta gcccgtgggc 575880 tctagtccag cctatgtaat gtggtctccc tcctccatgc tgaatccagg aaggtctgtg 575940 ggtcgctgtg cccatcagat ttctgtactg tcagaatgca agtgcacaca tgtgcatgca 576000 ccaactcact cagctctgac ctgaccgtct gcagggtctt ggctatttct ggacagatct 576060 ccatgttatg atttgacctc aggccactct caagccctgc cattgccagg gcagatatgt 576120 tgggcctgac atataataac ccatctcctt ttctgttgaa aacatgtgta tctatgcctg 576180 gataatccat agtcaacctc ctttactttc tgccctcacc cactgccacc agtacccaca 576240 aatctttatc ctaaccccta attagctaaa tggaaatctc cagtcccggt agcattgctc 576300 tgtgatactt cttggaggag gaagtagccc agccccaagc tgcccccaag cggcccccaa 576360 gctgcccccc atggtgaagc tttggccacc ttgaattaac cccacatgtt tcccaggctc 576420 tttatgatca ctcagtctgc tgagccaatc acctcccacc aagcccctct tccaacactg 576480 gaattaaaat tgagcatgag atttgggtag gaacacagat ccaaaccata tcaatcatca 576540 tttctgaatt atagtttaag tccttcccaa acatgacaaa ttagtgcctg aaatagaata 576600 tgaggtgtcc caggtttgtg aacacccagc ttatgcactt tcctaaattc agtcaccagc 576660 acccccagca gtcctccccc aacaatttat cctgcacata tgcaacactc agatccctcc 576720 tgcttcactc tcaagtccag ttgccagata cgtctgcaac tttgctggga gtttttccaa 576780 ggaaggagtc tcccgcagaa gcttcagagg gactgcagct gtgccagcac tttgattttg 576840 cacttctggt ccccagaatt gtttaagcat aaatttctgg aggcagaagc agagaatggg 576900 aagaatccag ggaacgtaag tgtgctggag gggacattgc ttagtgaagg aaacccctca 576960 gcagctgcca cgcccttggt agggcatcct gagctccacc caaacatatg catttccctt 577020 cctaagtcag cctgaagttc caccagctaa agattctctg gggtaaaaaa ggaatttgta 577080 aaacaggagg gtccatatag cagatgcaat ttgatccctg ctccagtttc aatttccctc 577140 ctttctctgt gctaaaaatt gaattatttc ccgtccaccc cctagatttg tatgttgaat 577200 ttgtaacctc cagtacctta tatgaccata tttggaaata gcgtacttgc acattgcagg 577260 tataattagt gaagatgagg ctctactgaa gtaggccgcc ggatccctaa tccaatatga 577320 ctggtgtcct tattaaaagg ggacaatctg ggtgcagaca cagatggaaa acatagctgg 577380 gcaaagacag agattggagt tatgctgcca caggccaaga gacactgggc aaggcaagga 577440 aggggtctcc tgtagaaact tcagagggac tccagccctg ccagaacttt cattttggac 577500 ttatggcccc cagaaagatg tgagaataaa ttgctgttgt ttaagcaccc cagtttgtgg 577560 aactttgtta cagcagcccc gggacaccat acactcagtg acaacagaac tcttttgcgg 577620 tcttgtgttg gagggaagcc caccacaggc cagatcccct gcctaagcag aagagtccga 577680 atccatcaaa gccactgggt gtgagccctg gccgggaccc atcaaacgca gcagctccct 577740 ttgattgaag gatgggcaga caaccagaat ttgcacaatg aaacgtaaaa acaattcttt 577800 tgaggagttt ctggagaaga tttccgtatt cttaatacgg gactctgcaa aagaggttta 577860 tcccatttaa ttcttgaccc catgatgtct ggcagtacat gagatcacct gggactttat 577920 tgcctttgct gtctaggcca atgtgggtca gggtttttgc atttgcagct ggaggcatcc 577980 aaactaatta gctaaggaga gagcagcatc tccaattcat ggagtgcgat tcagccacag 578040 tgttcccctc ggtaatcctg ctgaaataaa tggctctggg ggaatgagga gttagatctg 578100 gattgagaag ctatagggat ttgcagtgca tgctttgggc tggggcagaa cagctccgtg 578160 ggaggatagc tgaaggtgga tggcagcact cggacctggg cacatatggt ggcttacagc 578220 agggagctca gtacctggtg agggaggttc tcctgcctca gcttcccgag tagctgggat 578280 tattatagat gcccatcact acacctggct tatttttata ttttttcagt atagatgggg 578340 tttcaccatg ttggccaagc tggtctcaaa ctcctgacct cagttgatct gcctgccttg 578400 gcctcccaaa gtgctggaat tacaggcatg agccaccaca gcctttcgaa aaattactgg 578460 ggccagtaaa aatcttatgt ttccactcca ctgttctcct cctcctcctc ttcatccttc 578520 tgttttgagg cacccttcta ccaagcaact aaaatgttat tatttttttt aactttgggg 578580 taattgcgcc tatttcaatg tttttcagtt gatttaaggt ccttctgttc catggccttc 578640 ccctgtggcc agtggcactg atgttctgaa ccctcaatca gccattacct tccacactgg 578700 catctgctga gaagtctgag tgccatatgg tccttgactg tggggtcact gcttagttcc 578760 cttggaatct cctcctgtct tctggctgcc cctgaccaga cccacccatt tgcccatcag 578820 cagggttcac tgaatgctcc ctagtgtcaa gaattgttct acatcctgcg tgctctgaat 578880 aagaccaagt attagttcac cgtcatgcag cacaaattcc cttgagaaag acatggagat 578940 gggtatataa cataatgcct ggcagaggat acagtgatgt aagaaagcaa ggtgtgcata 579000 cgtcttggag aaagcattcc aggcaaatga attagcaagg gcaaaggctg aagggagaaa 579060 ttggttacat ctgtggagca gcagggaccc tgtttgctgg aatgtatata tgtgtgtgta 579120 tttgtatata cttgtgtata tacgcatgcc tatgtttgta tatatacaca tacagtatac 579180 atagacccac acaatccaga tttttctttc tttttttgag gtggagtttc tctcttgttt 579240 cccaggctag agtgcaatgg cacgatctca gctcactaca acctccacct cctgggttca 579300 agtgattctc ctgcctcagc ctcccaagta gctggactta caggcacctg ccaccatgcc 579360 cgtctaagtt ttatatttta gtagagatgg ggtttcagca tgttggccag gctggtctca 579420 aactcctgac ctcaagtgat ctgcctgcct cagcctccca aaatgttggg attacaggtg 579480 taagccacca cacccggccc ataatccaga ttttatgtta tatagttatg tgctgcataa 579540 caacattttg gtcagtgatg gaccacatct atgacagtag cccttaagat ggagctataa 579600 tggttaacat acatctaata tatgtgataa tggacaacat cctaacattg taacttaatg 579660 catgactcac ttgtttgtgg tgatgcttac ataacaaacc tactgccctg ccagtgtacg 579720 aaagcagagc acacattatg tacactatgt aatacttgtg ataataataa atgactattc 579780 atggtttatg tatttactaa ttgttcataa ttactttaga ctactccttc tacttataaa 579840 aaaaaaaaaa gttaactgta aaacagctca ggcaggtcct tcaggaggtg tccagatgac 579900 ctgttacttg ttttttcatt ttttaatttt ttctatttca atagctttag gggtacaagt 579960 gactttgatg acatagatga attgtttagt gataaagtct aggattttaa tgcacctatc 580020 atctgagtag tgtacattgt actcaatata tagttttcta tccctcacct ccctcccacc 580080 ctccccactt ctgagtctcc cgagtccgtt atagcactct gtatgccttt gtgtgcccaa 580140 agcttagctc ctacttataa atgagaacat gcattatttg ctttttcaat tcctgaatta 580200 cttcacttag aataatggcc tctagttcca tctaagttgc tgcaaaagac attatttcat 580260 tatttttatg gcttagtagt acttcacgat gtgtgtgggg gtgtgtgtgt gtgtatatat 580320 atatatatat atatatgcat gtgaaaattt caagatgata tatatctaac atatatatat 580380 acacacaaga tatacaagat taatctatat ataacatctt tatatatata aaatttcaag 580440 attatatata tatatatata tatatatata tatatataaa acatctttgt ccattcatca 580500 gttaatggac acttaggttg attccatatc tttgcaattg tgaattgtgc tgtgataaac 580560 atagacatgc aggtgtcttt tgatatagtg acttcttttc ctttggatag atacccagta 580620 gtgcgattgc tggattaaat ggtagatcta cttttagtta tttgagaaac ctccatactg 580680 ttttctgtag agattgtgct aatttacatt cccaccagca gtgtgtaagt gttccttttt 580740 caatacatcc atgccaacat ctattgtttg ttaacttttt aataatggcc attctggcta 580800 ggggaaggtc gtatctcatt gtggttttaa ttggcatttc cctaatagtt agtgatgttg 580860 agcagttttt tcacacgttt ttggccattt gtatatcttc ttttgagaaa tatccattca 580920 ggtcctttgc ccacttttta atgggattat ctgttttttc ttgctgattt ctttgagttt 580980 gtagattgcg gatattagta ctttgtcgga tgcataattt tcaaatattt acttccattc 581040 tgtaggttgt ctgtttactt tgatgattat ttattttgct gtgcagaagc tttttcatta 581100 ggtcccatgt atttactttt gcttttgttg cgtttgcttt tggggtccta gacataattc 581160 tttgcccagg ccaatgtcca aaagagtttt tcctagggat tcttctagaa tttttatggt 581220 ttcaggtttt atatttaagt ctttaatcca ccttgagtta atttttgtat ctggtgagag 581280 ataggaatcc agtttcgctc ttatatatgt ggctatttga ttttcccagc accgtttatt 581340 gaataagttg tattctcctt aaattgtgtg tctaatccat tatgttttta tatgctttgt 581400 caaagatcag tcagttgtaa gtatttggct ttatttctga gttctccatc atgttccatt 581460 tgtctatgca tctactttta tatcattaca atggtgtttt aattactata gccttgtagt 581520 atcatttgaa gttgggtaat gtgattctaa gaataaatct ttttgcttcg gatttctttg 581580 gctattctag ctcttttttg gttccctatg aattttatgt tttttttttt attttgtgaa 581640 aaacgatgtt ggtattttga taggaattgc attgaatctg tagattactg agcagtatgg 581700 tcatttccac aataccgatt ctttcaatct atgaacatgg gatgtttttc catttgtttg 581760 tcatctatga tttctttcag cagtgttttg tagttctcct ttagagatct tttcacctcc 581820 ttggtagagt atatttatta agtgttttaa aaataaagtg ttttattttc tttgtagcta 581880 ttaaaggggt tgagttcttt tttttttctt ttttttttga gacggaattt tgctctgtcc 581940 cccacactgg agtgaatgaa gtggtacgat ttcggctcac tgcaacctct gccacctggt 582000 tcaggcggtt ctcctgcctc agcttcccga gtagctggga ttatagatgc ctgtcactac 582060 acctggctaa tttttatatt ttttttcagt ataaatgggg tttcaccatg ttggccaagc 582120 tggtctcaaa ctcctgacct cagttgatct gcctgccttg gcctcccaaa gtcaggcgtg 582180 agccaccatg cccagcctga gatcgtgttt gattctcagc ttggtcattg ttggtatata 582240 gcagtgctac tgatttgtgt atattgatat tgtaacctaa gactttactg aattcattta 582300 tcagatgtat gagtcttttg gaggagtctt tagggttttc taacagaggt agttttactt 582360 ccttttttcc tatttggagg cccttgattt ctttctcttt cctgatttct ctggctagga 582420 ctgccagtat tatgatgaat ggaagtgggg aaagtgggca tcgttgtctt gcttcagttg 582480 aatgctttca gcttttcccc attcaattca gtatgatgtg ggctctgggt ttgttatata 582540 tggcttttct tattttgagg tatgttcctt ctgtgcctag tgtgttgaga gtttttatca 582600 taaagggata ttagatttta tcaaatgttt tttctgcctc tattgagatg atcatatggt 582660 ttttgttttt aattatgttt atgtgatgaa tcacattttt tgacttgcgt atgtggagcc 582720 atccctgcat ctttagaatt atcatggtga attatttttt tgatgtgcta ttggattcga 582780 tttgctattg gatttggttt gctagtattg tgttgagaat ttttgcatct gtattcatca 582840 ggaatattgg tctgtagttt tcctattttg ttatgtcctc tcctggcttt ggtatgagga 582900 tactggcttc atagaataag ttaggcagga ttccctcctt ctctgtcttt tggaataatt 582960 tcagaaggat tggtaccaat tcttttttga atgtctggta gaatttaggt gtgaatccaa 583020 ctggccctgg gctttgtttt gttggcattt tttttttatt gctgattcaa tatcactgct 583080 tgttattagt ctcatcagga tttctattta ttcctgattt aagctatggg gttgtatgtt 583140 tccaggaact tatttatttc ctctagattt tctagtttgt gtccagagtg gtgttcatag 583200 tagtctcaaa tgatcttttg catttctgtg gtgtcagttg tgatgtctcc attttcattt 583260 ccaattgaac ttatctgaat cttctttctt ttcttggtta atctagctag tggtctatca 583320 attttattta tcttttcaaa taacctcctt gttgtttcat tgatctttta taattttttt 583380 gtttcaattt gatttagttc tgctctgatc tttgttattt cttttcttct gctagctttg 583440 ggtttggttt gttcttgttt cattccttga aatgtgatgt taggttgtca acttctgatc 583500 tttcagactt ttaatgtagg catttagtgc tgtaaacttt cctcttagca atgcttttgc 583560 tgtatcccag agattttgat aacttgtgtc acagttatca ttcattttga aaaaaaattt 583620 aaatttccat cttgatttga tggttaaccc caaaatcatt cagaggtaga ttgcttaatt 583680 ttcatgtatt tgtatagttt tgagggttcc ttttggaatt gatttctggt tttattccac 583740 tgtggtctga gaagatactt gatatgattg aaattttctt tgctctgctc acacgtttat 583800 tcatccaggt aaacctaaac atgattttgt ctatttcaaa aataaccatt aagtaattat 583860 ttatagaata atttaatgtg agggacccac ctttttacca tattgagtca ttatatccag 583920 aaatgaaact tctctttatt gtctttagtt ttctggtaga ttccttaacg aagaggcaca 583980 gttgtctcca ttttggactt agacatattt tattaatttt taccaaagaa ttttgaattt 584040 tgtatggcat tttaaaaagg tatcttggct ttctctttta tttgtatagc ctaagcacac 584100 atccttatta atttaatact attggactct taattatgtt tgaatatttt tgcaaaatta 584160 acagcctcat ggtgagatgg ccaatggcaa gaaagctcca aggtgcatgc acattagttt 584220 caacaggagc tgcctgattc ttttcattga ttcaagaaac atttgctgag ttcttaccat 584280 gtgccaagca cggtattagg cacagtcagc caagcctctg agctgggatt cccaaactgc 584340 tgtccttgta cctcatttct atcactgccc tccagccaaa gcccatcagt cacatacttg 584400 tagggtacca agttgagttt attcttgtca tgagctaaag catacaacat ggaaacaatg 584460 agatgccttc ataagagggt gttgggaagg acgtattata aacttgggct tgtgttaggt 584520 gatttggggg aaggttcaag taagtaggac ctaactctgg agtgacgctg ccagaaagtg 584580 ggagtaattc tatgattggg tattgtcttg atttgttttc tgttgctata attattactt 584640 gagactgggt actttataaa gaaaataggc ttatttctta cagttctgga ggcggggcaa 584700 gttcaaggtg aagaggctgc acctgtaagg gccttaatgc tggtgaggac tctctgcaga 584760 ggctttttgc tgcataaagc atgacatggt gaggaagctg acctcatcta aatctaatta 584820 tctcctaaat atcctgcctc tcaaataccg tggttagatt tcccaccctc ttttgggagg 584880 tgggcttaaa caacagaaac ttatttctca cagttatcga ggctgaaaag tccaggatca 584940 agattctagc aaggtaagtt ttattctgag gtctcttttc ttggcttgtg ggtggctgcc 585000 atctcactgt gcactcacat tacttcttta tgtacacatg gacagaaaga aagaaagaaa 585060 gcgagaggga gagagagagg gagggaggga aagagagaga gagagaacac tcaagttaac 585120 tctcaggtgc cttttcttaa aaggatattg atctaatcag actagacctt ctcatgactt 585180 catctcactc taattacctc tcaaaagtaa ttacctccct gtctccagat accattacat 585240 tggttagggc ttcaacatat gaattttgga gaggtactac cattaaatcc ataacattaa 585300 atttctattt gtcagggttc tccagagtaa caaagccaat aagacatata gagagatagt 585360 gctatttatt agcatacata tttatatctc tttatattgg tatatatgta tatacttata 585420 taagaatgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tagagagaga gagagaataa 585480 gtttattata aggaattggc ccacatgatt atggatgcta agaagtccca ggaaagccaa 585540 tgtgtaattc caatctgaaa gccatcaagc tctagaccca aggagagcca atgtttcact 585600 cgaagtccaa agacaagaaa agaccaaggt cccagctcag ccatcaggca ggcagagttt 585660 cttcatactc aatctttttg ttcttttcag gtcttaaatg gatgggatga ggcccatgca 585720 cactagaaaa ggcaatctgt ttgactcagc ctaccaattc ggctttaatc ttgcccagaa 585780 acaccctcac agatacatat agaatcatgt ttgaccaaat atgtgggcaa gatttctcac 585840 ccccttagca cagttatata attgtggtta agtttcactg tgagtttcag aggggacaaa 585900 cattcaaacc atagcagata tttaataaat cttgttcata agatgagaga aatgaagcca 585960 ggctaatgct gttatgggta aagaagcagt ggtcagtcac gttagacaaa agaacagatg 586020 tttggtcatt gttgtggttt ctttgaacaa tgctcatgct attgtctatg ttcaaacatg 586080 ataacggagg ggtcttcttt tgtcttgatc catctcggtc acagagctgt tttgtctgat 586140 gttagtgttt tgtgaaattg tttatcttca ataacagaac accaaggccc aggtgggagt 586200 tcccagccag ctcctggatg tcgggggctt ttttccaatc tctagtttca ttattatcat 586260 gtaatcattt ttaatatcat tcatcttgaa aaggatgcag aagacaatac atagttttgt 586320 ttagacttaa ttaagaagag aagctacaca taagtgcttt catcaagggc cactagacca 586380 gtcttattgc aaactcagct gaaacaagct cctgacctgc aatgggcctt gtgaatgggt 586440 acatggaaat aagctgatgg acaggcaagg cttggagatg tttctctgat gatttattct 586500 ttgtagaatg caagtgcctg gttgtgatgc tcacttttct cttgaggact cccaggtgtg 586560 accctctgca gggaccatcc tcactcctca tgttaggaca tatccaaaga caacagctac 586620 ggagcagagt cactgatgca catttgtaaa gcaatggcag gtcatggcaa gtgtccatgc 586680 tacagggcag tgacccacca tctgctcttt gcagttcagc tgtggctgag gcaggaaggc 586740 agagacaggg ctggaggtgg tagacttttg aatatactgt tttcccacct atttatttca 586800 atttccacac ccttaagcca attgattcca gaacctcaag ttagatgtcc actttttgtg 586860 gctatccgtt tggctactga ttgtaagaca cattacagag gtgtacagtc catgtataca 586920 caggcaagta aggatcttct cattccaaag atgcttgagc agaaaagagc acctgatttt 586980 cagctcattc tgaacactgg aactgtgact ttaatcatca gtatgttgta taataaaacc 587040 tgaaggacta cacaggataa gcattgttag ttaagaatgg ctgactcggc tgggcgcggt 587100 ggctcacgcc tgtaatccca gcactttggg aggccgaggc gggcggatca caaggtcagg 587160 agattgagac catcctggct aacacagtga aatcccgtct ctactaaaaa tacaaaaaac 587220 tagtactctt gtaactgtac aagagtacac cgaacaaagg agacagggtc atttataaca 587280 ggtgtggtgg cgggcacctg tagtcccagc tactcgggag gctgaggcag gagaatagcg 587340 tgaacctggg aggcagagct tacagtgagc cgagacttcg ccactgcact ccagcctggg 587400 cgacagagcg agactccatc tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aagaatggct 587460 gactcaaaac tttcattctc tctaagaact attcagtaac cagtattcaa ctgattccag 587520 ttgtagcctt ctttctaagg aaatggaggt aacttttaac ttctgggccc agatgcatcg 587580 cctctttaca ggtgtggcct aattctcatc tctggttggt gctgtgggat ctgctccata 587640 ctgggaagtc cctgtctagc ttcttgcccc ttattactta gcttctgtat ttgctcagag 587700 tggagtcttt attcttaatg agaaggaggg aagccatatg cattccaggg agatggtata 587760 accagagaaa aggccctatg gcaagaggaa gcttggtgtg tttcctccat gacactgctg 587820 gggtaaaaaa aaaaaaagag ttcattaaag aggagatcag atccttcgag ggaggtgaga 587880 actttgcatt gcactctgga tggatggcca ggctcttcat ttttcctttt tcctagtagg 587940 catattcata tgtgtaagcg ttttctcttt taagaaaatg aaatcacaga gtatatgtta 588000 gtatgcattt gctttttaag ttgacaatat atcacagttg tctttccaga cgttagaaat 588060 acttgttcct cagtgccata aagaaatagc acttcaacat aaatttaatc tcctcagcag 588120 tgccattttt actttctgca gaaggggtac acccgccagc agttttgccc caagagtaca 588180 ccaaacaaag gagacagggt cgtttataac ctgaggtgtc cactctactg ctgtgtctgg 588240 tttccattgg ctggaacggg acctcacatt ctgtgtttgt ctcgattggc tagcaactta 588300 gaacttttta aaagaggtaa agagagagga gaacaaaaga aggaggaagt aacttgtgga 588360 atgctgagaa aggtagaaac accttcaaat aaggaagagg aacaggctat gacctaatgc 588420 ttgtttggac cagtataagc atgccagggc agatatttaa gctaaattgt gggagctaag 588480 aacataaagt accttgattt cttcattgcg gctagcagac atttaagaat gttagcacag 588540 gtctttgaat aaatttcgct tctaagagaa gttactgttt attcctattt agatggggag 588600 gaaagtcttt gaagaggaac ctctacttta ctttttacac agataaatac acatagctcc 588660 attttattgt atttcaggag tagctcatat ttcactttat ggtttggcat cattttgcaa 588720 ctgttatctt agttggacat tcagcttgga aacaatttca tgtgttcctg tcatttgaga 588780 ataacatttc taggccttgg aagtagtagg ttctcaacca gtgtttgcag caggaagaaa 588840 tgcaagaggg aaagagcagg agagctgatg ccagacatag aagaagatct ccaggaagaa 588900 gttttggaag acatgctttt aggttttcat cgcttctcct ttttgtatat ggtactgctg 588960 aatgctgcta ggaacaatac tttctccccg gagatgcagg tcagatgcca tgttttctgt 589020 ggctcattta gattgataca gaatgggcca ttgctagaaa atggaaacaa aacagtcaga 589080 aagcacttca caattctgag tctgtagcca ttgattgtaa atgtgcaaga ggagaaaaga 589140 gcacttttgc ttaaaacccc attgataatg cagcaagggg aaggtacatt gctctgtgaa 589200 aagaataagg agaaaggggc tttctgtagc cataaactgc attaacaggc acataatacc 589260 atgagtgttg tcattgtcat cacaccatgg agccacctct gtgctacctt ggccatgtat 589320 tgaagccagg agaaaaaaac aagggtaagt gcatgagcat taaaaaaatt aacgtttgga 589380 agtcctgagt tgtcttttat tttctgcgac ctctgagaag cccctctttc tcatgtgcca 589440 ctgtaaaatt atttccacaa ctgtaaaaat tgggattgta gtaatgctaa atgaatccat 589500 tctgctcatt cagtcctgtc tcccaaggta atcactgtaa aaggctaagg atgatgcatt 589560 atgagagaat agcatagcca tgtggagagg cagtgccagg gagtgcgttt gccattgtgt 589620 gtgtgtgtgt gtgtgtgtgt gtgttcagca aatacagcca gccctttgaa tctgcagctt 589680 ccacactcat agattcaacc atcctcaaat aaaaaatatt cagggaaaaa aaaacaaaaa 589740 aatacaacaa taaacataaa tacaaatata acacagtaca atacaacaac tatttggata 589800 gcacttgtat tttattaggt ttcatatgta gtctagatgg cacctaaagt gtgcaggagg 589860 atgtgtgtag gttagctgca aatactaggc cagtgcatat gaaaagtctt gaactctctc 589920 agagttttgt atcctgtatg aggggttcct ggaaccaatt ccccaaagat accaagaaac 589980 aattgtatct ttgttttctt tcctctctta tcccattatc atataacata tgatacattg 590040 atttgctatc atagtattta agtattgtca acttcacatc atagtagtaa agttacggga 590100 cattaaggag aggcatgaac atcaccaaag gactttgctt ttcttttagg gacagggttt 590160 gtgtgctttc agttgtgctc agggtagtga tattatgtga agtggaagta taaccttgtt 590220 attgtcttta tttgaagagt aagtatggtg taagcagacg tgcatggatg ccgagttgac 590280 aaggtgtgga tttgtgatgg ttaattgtat gtgtcacttt tgctaggcat ggtactcaga 590340 tgcttggtca aaagccagcc tagatgtcgc tgtgaaggta tttcttagat gtgattaaca 590400 tttaaatcca tagatttttg agtaaagtag attatccttc ataatgcggg tgggcttcat 590460 caattaaagg tccttagaaa aacagactga agtccctgga agaaagagga gatgctgcct 590520 ccttcggacc caagctgcac atcagttctt tcctgggtac agcctgctgg ctggcccggc 590580 aaattttaga cttactagcc cacacaattt catggagtgg ttccttatca taaatctctc 590640 tgtctctttg tgtgtgtgtg tctgtctgtg tgtgtctctc tctctctctg tctctctctc 590700 tctctctctg tctgtctctc tctctcctat tggttctgtt tctctgggaa gccctgacta 590760 atgcagattt tgatattagt ggcctaaaag ttcaggaagg attatattcc cacacacatg 590820 ccttgtagca cccacagcct aaatacctaa atacctccct cagcaaaatg acacatatta 590880 acgtgtgcat attttaacat gccgtgaact tccatgctgt ttacaaaaag ttgaaactgc 590940 aaattcactc tgtaaatgct tcagggtatg ctgcatttta atttgggaat acagagtttt 591000 aaagactcaa gtccaaaaca tacattggat accttctgta ttagttttct caagttgcca 591060 ttacaaacta ccacaaactt agtgacttaa ggaaaatacc cttttattat ccagagtttt 591120 gcaggttggg catccagtgg cttggctggt ttctctgctt cacatatcac aaagccaaag 591180 tcagagcgtc cgcagcactg tgctcctctt actggaggac ctgggagaga attttcttcc 591240 tggctctttc tgactgtggg cagaattctg ctccaggtgg ctgtgagaca gacatcgctg 591300 cttccctgcc agctgtcagc taggggttgt cctgagctcc tataagcctc attctattcc 591360 ttgcatataa tcacttacat ctcagaatta gccaagtgtg gggtgagtcc ttctgacact 591420 tcagatctct gactctcctt ctgttctgtt tcttttgctt ctgtttctgc cacaaggcat 591480 ggactgactc ctctgctttc ttattctgca tttaaagtcc catgcgatgt ctctggaccc 591540 acccagagaa tttaggatct tctccctatt ttaagatcag ttaattagca accttcattc 591600 catcagcaga atacctttca ctgtgtacag taacatattt atgttcccta gattaggccg 591660 gggaggtctt tgaagcacca ttattctgcc tactgtattg ctatgagcaa ggactgtaaa 591720 tgtcctcgcc tttaagtctt ttatagactc actggggaaa agagccacat acatgtagta 591780 gatcatttgt aacattatct caaaccataa catggggttg cagagcggaa cccggcttca 591840 tgaatcacac cacaaaaacg gagcgggagc tgtctgagtc accactctct ggcacagaac 591900 acccagcaca cagtaacata cacagcaggt actcaatggt taaagggatg aatggatata 591960 gaggaaaact gagtaggaga cttaaaaaat ggagtcgtct cctcaatggg atttaacatc 592020 ctttatttac ctgtttattc cataattata tattggaagt ctaatctata caactgccag 592080 tgctgggcct tagagatgca attgtgatta gaccaggggg cctttaccca cacggagctt 592140 ataatttgac attaatcata tcagcagatg aataatctca cagttaaaac atgcaccaaa 592200 tataatgaag gcacttacta gatggcacgt gagagataag ggaaagccac tctgaggacg 592260 ctgatttttg agtggaaagc tggataaagg aggattgtct taggctggct tctggcaggg 592320 atctgtgtgc tggaaacctg ctggaaagcg cttgggatca acgccatagg gggagtacag 592380 gaagttggag aggcacagaa agaagctggg atgcagatgc aagcagggcc cagctgatcc 592440 tgcaaagagc tctgaagctg ggtggccctt ccaaggtggc tggggctggg ggcctgggct 592500 ttatacccac ccccgtgaac cagtcacctt gattctgtgt gttaagtcat aatgtacctc 592560 agttttctgg aggtgagacc tctgttttca atggttggaa aagctcatga ctataagcat 592620 cagatgcatt cgtattgcca actgtatcat tttgtatgcg tcagaaaatc ctttcttgct 592680 tagaggaatg ggggagcata atgaatcagt ttaaatttgc tcccatcacc accttccacc 592740 gggttctgag cttttactta tttccttata tcatcatagc cagtccaact taaactgtga 592800 tattccaccc tccccctgcc tggagtgttt ggtcttttca ttcagggtaa cttgcctcta 592860 ttgtaatggg gtgatatgat atgaggagat catgcaaaac aaaggctctg tcatttatct 592920 tagctgtgac tatttatcta atatttactg accatcaaag ccctcactct gtatggaaaa 592980 cagccttcaa tattgtctga caccaactgg gtatcctaca atttagtttg attcaggcac 593040 taattacctg gagttcgtat cagatcccat gagttaaagg gcaagatccc taacaagact 593100 gctcttatgt cagacaccag cagtgagtgg ggtcccaggc ttcccacact tctgcctgga 593160 tagctgcaaa ttcaagatag cacaccctcc ttgggtttga taatctgcta gaacctctta 593220 cagcattcag gaaaatgcca tacttaacaa ttaccatttt accaaaaagg acatgagtga 593280 acagccagat gcacaggtac atgtggcaag atccggaagg gtcctgagca caggagcttc 593340 cagccttgtg gatctgggtt gtgccgccct ccgggcgtac ccatatattc accaaccagg 593400 aagctgtctg agttgcattg ctcagagttt ttatctaagt tttattacgg aggcgtgatt 593460 gattaaatca ttggccacat gactgagatc tatttctagc ccctcttcct tccccagagg 593520 tcagggggtg aggctgaatg tccccctcct ctcatcacat ggttggtctt tccagaaggc 593580 cagcccctcc ttgataatca tctgagggcc caccataagt cacctcatta gcataaactc 593640 aggtactgca gaagtagaaa gggtctgttg tgagtaactg aagacatttc tatcactctg 593700 aaaactccaa gaggttttga agctctgtcc cggaaccagg aacaaagacc agatatattc 593760 tgcattgtat catgtaatca aatacatgca atttatttgg cagggaattt ccaggctccc 593820 tgctatacag tccctaacag agttaggaga atgataaaga ggtaaataac atcctccctc 593880 ccacgatgct ccccaatgcc ttgcagagac ttgtgctaca gaattccctc actgtggacc 593940 aaccatccta agcccagata gtttctgtag tgtccatgga aacttaggca tcatcgtcct 594000 gtgctcacac ttcacctgtc ttctccctcc tggtttatgt cttcctgctc aggtatgtgt 594060 aaggcagata aacatgtcac ttcccaatta aatagcaaac agaagaatat aaattccatt 594120 tacccacttt acaggcactc ccaacctctg tgagtgatac gttctcagcc ccccgcccct 594180 tacttgggtc tagggggaca gacaactcga gccttagcac tctctagtaa cccaggacaa 594240 ttttctcttt ctccccactt cccccaattt tgttttatac gttgggaagt tgtggggact 594300 ggagtaatga ttgagagtag cagaacttaa gcctttaatg ggaatctggt tcccatagtc 594360 ttgaaaaaag tttaaggatg tgatactttg atcctcaatc ttgaatcata gaaacaaagt 594420 ctagggcaat agtaaaaagt ccctatcaaa actcacttgc atgtacctgg ccacccggct 594480 ggcccttctt agtatttttt ttctgattat aacaattaca caggttccca tatattttaa 594540 aaataaaata atagattgaa aggtagaaaa atctctcctt atcccaacac tcaaaagatg 594600 gtgatagaaa tatttctctt tttcctactc aagatctgaa atttatgagg gaaacaaagg 594660 aggaaaacaa caaaatctca tttgtcaaag ataaaattca tgtgagacaa tgctgtttat 594720 atctatgggc agatactcct cataacttaa gctaagaatc cagtaggctt acccagacag 594780 tcctaggcat cacaggaccc caataccacc tctgtaccct accaaagatt agggccaccc 594840 atgcatactt tatggcataa aggtctgatt ttattatcta tgtctttgta actaattatc 594900 acagattttg cagcttaaaa tggcatacac ttatgttctt acagtttttg tgggtccagg 594960 agtccagaca tagcttactg aggtcctggc ttcaaccatc tgaaacaaac agctttctca 595020 atgtcttcct caaggctgca atcaaagtag tagccatggc ttaggtctca tctgaaggct 595080 caagtgggga tctgcttcca agttcatgta attgttgtca ggagtcaact tgtggcctca 595140 cttactcttt ggctgttggc caagtaaagg tcacccttgg taccttgcca tgaggatgtc 595200 tgcaacatgg ctgcttgctt gcaagtgtcg tttgtttgtt ttgttttgtt ttaaaaaaaa 595260 gaaagaaaag aaaacatgca agtggagaag gcaacagaga gagttgaaag atggaagtta 595320 taatatcatg tgagcttatc aaggaaatga tgtcccacta tctttgccat atttaagtga 595380 ttagaagaaa gtcacaggac ctacctacac tcaagaatag gagattccac aagggcatga 595440 atatcagggg acaggatcac tgggggctat cttggaatct gcccactaca gggtgtttct 595500 taggaactgt cagctcccaa caaaaagtac aggaaagggt agagctgtat atgcctagtt 595560 cccacttcca aactcattat caagtgtaag tcattccttc tatcccaaat taaaacaagg 595620 gaagactagg aaataggaga agtgttacct caacaggtct gatctacgta gaaggaaaca 595680 tcgggaatgg tgagaaaaac cctccctcac aaaaaaaaat taatatagtg ataaatctcc 595740 ttgtggccta tttttttttc tctctgctaa tatgtgctga agcatttttc tgtaactaga 595800 aacatctgaa tgtactgttt aataacttag cctttattct gatctatatg tgttgatttt 595860 tttctgtgtt actcagtatt cttctgctat gtgcctttta gtggtctgca ctctctatca 595920 catggccagc ccagtaactg tgtagccagc cctcgatggc ccatttgact ctggtccctt 595980 acagcctcca agctgcatca gcagcatagc tccctccacc atatttcatt gatgacagaa 596040 gagaaggcag gcagcatgct gcagcacaag ggctgtggga gcccagaagt ctgcaaaaag 596100 gcctccactc ccttttcagg atatcaggtg atagagattg agcaaatgct ctgtggtgtt 596160 atcagtgccc agaactggtc tgataagcag ggaaagacgc caagaaggac agggtcttgg 596220 agatgcaggt aacatgtgca cccagcccag ccatcaccct tttcccattc aaatcttgaa 596280 cttgccaagg tagcccttta ttgaagagtg cttaattact tccggccacc tccatgaaca 596340 tgaacatgtc agtaatcttt caagtcttct cattagcagt gaggttggga acgtcagccc 596400 cgacccagtg cagcacagca gccctcactg agctgtcgct gccacttcag gaaagtgtct 596460 taatgtgagg gctgcctttt cacagattag tgacggggat gaaaggaggc aacagtgaag 596520 ccatctgggg attcagacat tctgggttaa ttctttgtga gaaaatgtaa aatggccaca 596580 ttttgcactg tattagcagg ccatctatca caactgttta agtgtggaat tttttaaaaa 596640 attatgaaag aaccacagaa gatgcatcaa gctaaattga aatttttatc tgcagcttac 596700 cacatagtgt catatataca ctcttacttt atgtcttcct gtcttgatac aaccttaaag 596760 gaagtagcct tcatctccct ttattcatat ttctaattga ggcccttgac ttttttaaaa 596820 aacaccaaaa ttccttacca tgtagaagtt tttcagagat gtcgcagacc acatgaagag 596880 tgttggggtc cccagatgct gcatgaatta agcttgcgac agaggctgtg aatccccaaa 596940 ccgtcatagg tcattctact ggcctgaacc ctgcaattgc caaacccagg caaggatacg 597000 acattgtctc atgtttaaat tccaaggtca tggagtcaag gtcaatgtga gtagaacctg 597060 caaaaacagt acaaagtgac catgttctca aggttaaaag tcaagagaag gacctcagct 597120 tcctttgaaa tggctccacc caggtctcag atgtgtgtca gcttagggtt tccttccact 597180 tggaatagtg ccaggaggcc ttgatctcag acaaaatacc ttgaggcctc ttccttatta 597240 ggggctgggg ctacacacct aactccttca tccttctttg gagcttggag gttgttctct 597300 tctcttctgg ctgcaaggaa cccctgcatt ttccccatga agccatgatt acctcaactc 597360 tgtgtttcct aaagcttaac tcccagcata ccaggttgca aagagagctc acttctgacc 597420 ctgagacctg ccacatcaca cactccagag agacagctgc cttcatgaac aactttctca 597480 aacctgctga aatgttgctt tcatactcgt gtttgttcac ccttcacaat tcccatgatt 597540 tgaatatatt tctacgctaa tgtatcgttt tgttttcatg ctgctaataa agacataccc 597600 gagactggga agaaaaaaag tttagttgga cttatagttc cacgtggctg tggaggcctc 597660 agaatcatgg tgggaggcaa aaggcacttc ttacatggca gcggcaagag aaaatgagaa 597720 ggatgcaaaa gcagaaacct ctgataaaac catcagatct catgagactt atccactacc 597780 atgagaacag tatcggggaa actaccccta tgattcagat tatctcttac ctggtccctc 597840 ccacaacaca tgggaattat gggagtacaa ttcaagatga gatttgggtg ggaacacaga 597900 gccaaaccat atcagctaat atccaacaat actgcaattt gcataactat ctgccctgct 597960 tcagatgaca aaactgatgt tcattggtat gatttggctg tgcccccatc caaatctcta 598020 ctagaattgt atctcctaga atttccatgt gctgtgggag ggacccagtg ggagataatt 598080 gaatcatggg ggtcagtctt tcctgtgcta ttcgtgtgat ggtgaataag tctcatgaga 598140 tctgatgggt ttatcagggg tttctgcttt tacttcatct tcatttttct cttgccgcca 598200 ccatgtaaga agtggctttc gcctcctgcc gtgattctga ggcctcctca gccatgtgga 598260 actgtaagtc caatccaacc tctttttctt cccagtctca ggtatgtctt catcagcagt 598320 gtggaaacag actaatacag taaattggta cctgtagagt ggggcactgc tgaaaagata 598380 cctgaaaata tggaagcaac tttggaactg ggtaaccggc agaggttgga acagtttgga 598440 gggctcagaa gaatacagaa aaatgtggga aagtttggaa cttcctagag acttgaatgg 598500 ctttgcccaa aatgctgata gtgatatgga caataacgtc aggctgaggt ggtctcagat 598560 ggaaatgagg aacttgttgg gaactggagc aaaggtgaca cttataatat tttagcaaag 598620 agactggcag cattttgccc ctgtcctaga gatttgtgga actttgaact tgagaaagat 598680 ggtttagggt atctggtgga agaaatttct aagcagcaaa gcattcaaaa gatgacttgg 598740 gtgctgttaa aggcatttca ttttataagg gaagcagagc ataaaagttt ggaaaatttg 598800 cagcctgaca atgtgataga aaagaaaatg ccatcttctg aggagaaatt tgcataagta 598860 acaaggagcc aaatgttaat tcccaggata atggggaaaa tgtctccagg gcatgtcaga 598920 ggtcttcata gcagccgttc ttatcacaga cctggaggca taggaggaaa aaatggtttc 598980 atgggccaac accagggtgc ccatgctgtg tgcagcctag ggagttggtg ccctgcatcc 599040 cagccactcc agccatgact aaaaggggcg aagggacagc tcaggccatg gcttcagagg 599100 gtgcaagccc caagccttgg cagcttccat gtggtgttga gcctgtgggt gcacagaagt 599160 caagaattga ggtttgggaa tgtcctccta ggtttcagga gatgtatgga aatgcctgga 599220 tgcccaggca aaagttcgct gcaggggcat ggtcctcatg gagaatctct gctagggcag 599280 tgtcaaaggg aaatgtgggg tcagaggccc cacacagagt ccctactggg gcaccaccta 599340 gtggaactgt gagaagaggg ctactgtcct ccagacccca gaatggtaga tccactgaca 599400 gtttgcatca tgtgcctaca aaagtcacag acattcaaca ccagcccatg aaagcagctg 599460 gaatgaaggt tgtaccctgg aaagcctcag gggtggaact gcccaagacc atgggaatgc 599520 atctgttgca tcagcatgac ctggatgcaa gacatggagt caaaggagat cattttggaa 599580 ctttaagatt tgactgccct gctggattgt gggctttcat ggggcctgta gcccctttgt 599640 tttggctaat ttctcccatt tggaatggct atatttcccc aatgcctgta cccccattgt 599700 atctaggaag tagctaggct ttgattgcac aggctcatag gcagaaggga cttgccttgt 599760 ctcagatgag actttggact gtgaactttg ggttaatact gaaatgagtt aagactttgg 599820 gggactgttg ggaaggcatg attgtttttg aaatgtgagg acatgagatt ttggaggggc 599880 caagggtaga atgatatggt ttggctgtgc ccccccacca aatctcaact tgaattgtat 599940 ctcccagaat tcccatgtgt tgtgggaggg tcttagctgg aggtaattaa atcatggggg 600000 tcagcgtttc acatgctatt ctcatgatag tgaatacatc tcacaatatc tgatgggttt 600060 atcagggatt tgcgcttttg cttcctcttc atttttctct tgctgccacc atgtaagaag 600120 tgcctttccc tgcgccccat gatgctgaga cctccccagc catatggagc tataaatcca 600180 attcaacctc tttttcttcc cagcctcagg tatgtcttta tcagcagtgt gaaaatggac 600240 taatacattc atcaaggtta aagattgacc caaggccaca tataggtgac cagctgtctc 600300 agtttccctg ggactctctc agtctccaca ttgaaagtcc tgcatcctgg ggactcctca 600360 cacagcagga aattaaaaag ctgagattta aacttgggcc ctctccaggc tatccactgt 600420 gggcttctgc ctgatttcta gcactgttct ttacagtagt atggacttca ccttcattgc 600480 tgttggatac ttcttcaccg tgttagtcat gagtagtgca catctaccca ccccaagatc 600540 ctgctctcct ggggcctctt tttttttttc tttgatatag agtctctctc tgttgcccag 600600 gctggagtgc agtggcgaga tctcagctca gtgcagcctc cacctcccag gttccaacag 600660 ttctcctgcc tcagcctctt gagtagctga gactacaggc atgcaccacc acacctagct 600720 aatttttttt tttttttttt tttttttttt ttttttttta gtacggactg ggtttcatca 600780 tgttggccag gctggtcttg aacttttgac ctcatttgat tcacctgcct tggcttccca 600840 aagtgctggg attacaggtg tgagccacca tgccagagcc tcttttctgc ttctttctgg 600900 acgtatagga agtgagtatg ggattcttgc ccatgttcac tcaggctctc tgaacaggct 600960 tcttgaggat gttttttaaa atctcctttg gcttttattt gagagtctag attcaggcaa 601020 cacctcattt gatgccatag aatgagtgtt cccatgagct gagcagagga ggtggggttt 601080 atagagagaa aaggcctgag gaaagcagat acagagaaca aaaatctgat gggtagttta 601140 aaagtgactg tccttaaagg gctaaaacag aagggacttc cctatcctgc cagcttaggt 601200 aagcttggcc ccttctgatc cattgctgtg gagctcctag tttttaagga acaggaacct 601260 ggatcttatc agcaatctac catccccgtt cctcctcctg gctagataag tatgaaagcg 601320 tcattgattt gtccagtttc agaataatga aaagcacaaa agcccatggc agaccagagg 601380 tgtaatgtcc atggctcagg gaggctcaca cacaatctct tcctcatttg ttaattcctg 601440 gcataaagga aaaagagaga ctatgagctc cacccaccta agcgagcctc cctgccagca 601500 ccaaccctga aagggtgaaa agcagagatt catgtcatca aaacacttgc aaaattcccc 601560 tgacttgctg cttgataggc ctcccttcag ggagaggtgc aggtggaggc atcttcagaa 601620 gccatcccag ccccgggaac ctcatgcgaa atcacccagc aagctatgat ggactgggct 601680 accctctcag ctttcctttt ttctcatgtg tcagagagga gctagggtaa atcctgaaaa 601740 catgaaacag ttcccagaca cgaggacttg cccttgttag gataacaggc ccctttttgt 601800 cctaaagagg tcctcccact cagagggatg agcaaactca gggctgctgg ctgcctctcc 601860 agaccaaatg cacagctttg atttaaggac ttgcacctta atcacccatc atgtgtcatt 601920 accccaacag gcggcagcag ccgtaagaca caagtgccaa taaattgtgc tgaaagttac 601980 tggagtgatt ctttgtttat tttctctcac agctattctg tgacacttgg gctggcattg 602040 gaacaacatg gttgccacat gtaaggaagg ggttcaaggt gactggggga agcaggagca 602100 tccctccctc cctccctcga ttttcttcct gtagattccc agtgcctcgc tcagctctct 602160 aggaagtcaa gcccttggca gtcggcggaa atgagcactg tctcattagc taattgccag 602220 tacagatttt caagtacttc tgcatgcaaa tcataacagc actgagcttt cttgcttttt 602280 aaaactcctc tttcacccat cccaccccct ggcttctgga ggaaaatgag gtctgttaca 602340 aactgcacat cagattactt ctggggcttt tctggctcac gtttcccacc ctcgccgccc 602400 caacctgagc agagctccta actacctacc taccactgct gtgagggacc atgaagcaga 602460 aggtgctact tagctttggt ccagaacacc ttcagcagct ttcctcgtgc gccccatccc 602520 ttcaggattc atctcagacc tcttagatct gcatcacaga aaacaaaatg caaaccaggc 602580 acagggactt aagaaaatga ttgattaaat ggagagtagt ctactgctgc acaattgtga 602640 cttttttttt tttttttttt ccggagacgg agtctcattc tgtcacccag gctggagtgc 602700 agtggcacaa tctgggctca ctgaaacctc cttctcctgg gttcaagcga ttctcctgcc 602760 tcagcctccc aagtagttgg gattataggt gtccaccacc atgcccagct aatttttgta 602820 tttttagtag agatggggtt tctccatgtt ggccagtctg gtctcgaact cctgacctca 602880 agtgatccac ccgccttggc ctcccaaagt gttgggatta caggcgtgaa ccactcttcc 602940 cggtcacaat tgtgaatttt aataacagtt tggctccaat cagtatgata aaagtcataa 603000 gatattagtt caccgtgaca gaatggtcca tttccacatg gcagtagacc agtttaaaaa 603060 tggtctcctc cttgtgttgt ctaaatgggg aaggaacaac ccatttgggc atcaaggtgc 603120 atttattttc cacttgtctt tagctgtgct ttctggggtt gacaggactg aaatgaacat 603180 cacagatggg aaatgacccc gtcaccgtca gaggtccctc cctctgatgc ctgtgtggat 603240 cactgccccg gtagaccgtc tccatgacac tgggggaaat taatgtgatg acaagcaatg 603300 gtggctgctg gcaagggtgt tccattcctc tttctttgca ttatcctttt ctcctccaga 603360 aatgctcacc gaattcagca atcacacctg ggcattctct gaagtcatgg aatacagtgc 603420 tgaaacaatg tgtggaggag caaaaaatct aggattttag aaggctgcca tgtcacaggc 603480 agggctggct ttatggggga gcaaacggtg cagtcacaca gggccccaca ctcagaaaaa 603540 accgatgctt ttatttattt actgctgtca tcatcttgca aatcttagtt tttgaatgag 603600 aagcttcaca tttccatttt gcactgatta tgtctcctgt acaggtaata tgtgtgaaaa 603660 tattcttgtt aaaagtgctc atttctttcc ttttttcact acctttcact attgaaaaag 603720 aaaaagaaat gcatttaaga agacagtctg tgctttttta ccaaagcaaa acaatccaat 603780 caaggaaatg ctcaatccat cccctcccac aaagactgaa attttatttt taaaaaaatc 603840 actttattat ttttttcctt tttctttatg attgtacatc tgctttaatt ctaaattgca 603900 aaatgtaaca ggagtattgc agggagacct cttctcctga gctttcatgt tccaaagtca 603960 gtctaaatac atgagaacat tcactgtaac agaatcccag gggtggtccc aaagcacaga 604020 ccagatcact cagctgtgag gtgggagact cagatatcat tagctgtaaa tagaaaacag 604080 gaagcaaagc cccagacaca ggggagtctt atgttactag aataaaatgg gtaataaggg 604140 gtcaccttca aggacagaag ttgttgagag aaggacctgg tcgtggctgg aagagctgta 604200 cgtgaggtgg aaatgagtgg tgggaaacag atccagaaaa gtcctgtgcc agtgaggata 604260 gagggttctg ctcagtacgc agcaacctgc ttcttagctg cttaaacaaa gagttgttta 604320 tcactcacac aatatgccca ctgtggggtt gggggcaggg ggatctgctt attgtgggct 604380 caggatccca gactgacaaa acaagcacca tttcaaagtt gcatgtcaca gtgtcaataa 604440 gagtggcctg gatggtgcca tcataacaag gcttccagcc tggaagccac acatggcact 604500 tctgctcaca actcattcac tgaaggctac acatggtgct tatgctcaca gcttatttgc 604560 tggaagctca tgtagtactt ctgctcacag ctcattggct ggaagacaca catggtacca 604620 catggtactt ctgctcacat ttcctgggtc agaagacaca tatggcactt ctgctgacag 604680 ctcattggtt ggaagataca catggcactt ctactcacag ctcattggct aaagccagtc 604740 atatggcccc atccaaccac aagggaccag gcagaacaag tttcccaggt gctcagaagg 604800 tagatgagcg gaaacatgtg acagacagca ctcacgatca ccacagagcc taaaacatta 604860 ctttatttac ttgattattt tgaccgttca tccatttgtt cattcattcc ttcaggagtc 604920 catctaacaa agtcattttc tttcttttaa aaaaaaaaaa aaaactttta ggttcagggg 604980 tacacatgca ggtttcttcc ataggtaaac acatatcact ggggtttgtt gtacagatta 605040 ttttatcacc caggtattaa gctcagtacc caatggttgt cttttctgct cctttccctc 605100 ctcccaccct ccccactcaa gtagaaccca gtgtctgttg tttccttctt tgtgtttata 605160 agttctcatc atttagctcc cacttataag tgataacatg tggcatgtgg ttttctgttc 605220 ttgcattagt ttgctaaaga taatggcctt caactccatc gatgtcccta caaaagacgt 605280 gatctcattc ttttttatgg ccgcatggta ttccatggtg tatatatacg gcagtttctt 605340 tattcaatct gtcattgatg ggcatttagg tggattccac atcttttcta ttcttaatag 605400 tgcttcagtg aacatttgct tgcatgtgtc tttatggtag aatgatttat attcctctgg 605460 atacataccc agtaatggga ttgctgggtt gaatggtagt tctgcttttt agctttttga 605520 ggaatcacca taccatattg ctttccacaa tgattgaact aatttacact cccaccaaca 605580 gtgtatgaat gttcagtttt ctctgcaacc ttaccggcac ctgttatttt ttttagactt 605640 tttaataata gctattctga ctggtatgag atggtatatc attgtcgtct tgatttgcat 605700 ttctctagtg attggtgata ttgagctttt ttcatatatt tgttggctac atgtttgtct 605760 tcttttgaaa agcatctgtt catatccttt gcccaatttt taatggggtt gtttgttttt 605820 cccttgtaaa tttgtttaca ttcctataga tactaaatat tagacctttg tcagttgcat 605880 agttttcaaa tattttctca cattctgtag gttgtctctt tactctgttg atagtttctt 605940 ttgctgtgct gaagctcttc agtttaatta gatcctactt gtcaattttt gcttttgttg 606000 tgattgcttt tagagtcttt gtcatgaaat atttgcctgt tcctaggtcc aggatggtat 606060 tgcctaggtt gtcttccagg gcttttacag ttttgggttt tacatttaaa tctttaatcc 606120 atctggagtt gatttttgcg tgtggtgtaa ggaaggggtc cagtttcaat cttctgcgta 606180 cggttagcca gttctcccag caccattacc attagtcatt ttctgtgggt aagatgtgat 606240 agatcttgat agaatcatca ggatctctgc acccaagaag cttagatatg gtggggaagc 606300 tacaaatacc tgttacaagg ggatcagtgg cactcgtcac aaatggcatg catgcctgtc 606360 aggcaatttg ttattggaat gtagaggagg aatccaatat tttcacacag ggcaatcaat 606420 ggatactgca caaaggaggg ggcattggag ctatgtagta aaaactatgc agtttcagta 606480 agcagaggaa aggacgggaa tggggaagaa atttctgaca ttgggaacag cctgaacaaa 606540 aacgtgaagg ctggaaaata taaggtaatt taggtagaaa aggctcacat gtaattcact 606600 gtcatcttgt ggaagacaca gaatgctatt aaaggcagac aaagtgtaat ccaagatgta 606660 tttgcagaaa agtaatgaat atctatctat ctgtatgcaa gatacattag aatgggtaga 606720 gttagaatag aaaaggaggc aaaaaaaaaa aaaaaaaaaa aaaaccagtg aggaagctac 606780 tgcagtagct agataagagg ggatgaaggc ctactgaaca aaggtagaat gggaatagaa 606840 aggaaaggtg gaggtccctg tgggacaggc aggtagatgt ggccagcctt cacctgcctg 606900 gcttgaatgt taatcgggag ggcttcctcc tgtggttgta tagatcggtg ctgcccaaag 606960 tggggtctgg ggacccaccg catctgcatt gcagggggcc caggggcaga tcttgtgaga 607020 aatgcaaatt cccctgggtt gtaccctggc aatttgtgtt ccaacaagat ctctgggtgt 607080 tttgtgtgca catgaaggtc tgagcagcta tggtagaggc gatgtgcagt gaatctagcc 607140 tccctatcca gtgttcctgc caggacctga tggaagtata actgagatgc tcgcctggag 607200 aggcccctgc gtatgtaccc cctggaatgg gcaggtgtta gacaagcatg gaatacatta 607260 aaaagtaacc atcctaaagc attcagggtt actgtataaa atatttccag cccggttttc 607320 taagtctttt gcatacaact tttgagtgct ttgggaactc tttctgaggc tggattaagt 607380 ttctactgct gtaacctatg ccacttctga gggaagaagc catattgagc ctcatctgtc 607440 cttctaaatc aagtgacttt ggaagtttcc tataaaattc taggcactta tgttcaatta 607500 ctttatcata tcttcccagc atagaaaaac ttcctaaccc agatgatctc attcacctta 607560 tgctggaaaa agcattacat tttatttcct ctcttataaa attactttct ttatctcttg 607620 aaaacttaga aggagcctct tctttcatcg ttgctttttt tgatttcttc ttgcacagta 607680 aagtgattaa ctcaaattta agaaggcagg tatccaaaaa tagcatatac aaaacaggcc 607740 tacttctcta tcttgtgatc taaagcaatg ttgttatagg ttattatttc cttttcctaa 607800 gaaacttgtg atatcaaaat tatatttcca gcatgtacta tcattatttc ttctcacttt 607860 gaaaaaaaag gaaaaactaa ttttcctgtt ctttgctagg gcccgattca tctttaagta 607920 tccgggtatt taaggttttg acatcctgaa acgctgtgca ttcttctctg cagaaaagac 607980 ctttggagca gactttctag agatagggag aaatgatggt aatccatcat aatggcctga 608040 ttccactctg gacacataac tgttctccat ctctgaagcc attcctaggg aaagtttaaa 608100 agatcataag ttagacggtg aatgatacac atgatgctca aattagaatc tacttttttt 608160 cagagtggca ttgacgctgc ctctcaagca aagagaagca ggatcatcac cttatatggg 608220 gacttatatc actgtcagat tcagatgaga agggcacagt cattctcacc tgaaagtggt 608280 aggattctag aaaattacgg aaagtctttt aattcctccc gagtactgca ctgtcacctc 608340 tgggagctgt caccaaaaag aatagttgca tgtcatttaa ggccatgtca agccggtact 608400 tagacatggt ttaggcatgg aaaaggaaag agatgcttct ggatggtgtt gcttatttag 608460 gcaacacaca aattagtcat tttcttttcc cccagctgct atggcacatg tgagagaaga 608520 cgcaatgctt tccactcaga gcgcttggtt gtctctgtct tcctccttct gagaggacac 608580 ctaggccaac atacctgcta ggtggagttt agcggtgaac acctctatcc cctctcctac 608640 tcgctgttag gcccagatgt ccccaaaagc tatccagctc taccacctcc ctggttttaa 608700 aacacagagc ctttggctgt ggattattgt gtaaagagga gattctcatg agccaaagtc 608760 tggcccattt tcagttcctc cacctggagt gccacatcct gagtatgctt gtccaaatat 608820 gtccaagggt cgttttcact ggagatgaga gagctaacta agaatgcaga ttcccattcc 608880 actttccaga ccacagaatc agacttgggg gctggagtct tatatttcta ttcctggagg 608940 cacccagttg attctttgga gtattatggt ttaaaaaatc ctcagattct accccaggga 609000 gggccatctt tccttcattt cctcccacat atccccatat ctgattcaat ttttctccca 609060 atcttccaca agctctttgg tagacagaaa actatacacc ccctccccag gatgtctgta 609120 gcccaaccca cggaatctgt gaatgtatta ctttacatga caaaatgcct ttgcagatgt 609180 gattaaggga aagatcttga gatggagaga tgaccctgga ttagccaggc aggcccagtg 609240 tcatcaccag gatcttcata acagagaggc aagaggccat gaaccaagga atttaggcag 609300 cccttaagag acttggaaga cagtgtggct attcctcaag gatctagaac cagaaatacc 609360 atttgaccca gcaatcccat tactaggtac atacccaaag gattataagt tattctacta 609420 taaagacaca tgcacatgta tgtttattgc agcactgttc acaatagcaa agacttggaa 609480 ccaacccaaa tgcccatcag taatagactt gataaagaaa atgtggcaca tatacaccat 609540 ggaatactat gcagccataa aaaaggatga gtttatatcc tttgcaggga catggatgaa 609600 gctggaaacc atcattctca gcaaactaac acaagaacag aaaaccaaac accacgtgtt 609660 ctcactcatc agtgggagct gaacaatgag aacacatgga cacagggagg ggaacatcac 609720 acaccagggc ctgtcagagg gtgggggcct aggggaggga tagcattagg agatatacct 609780 aatgtagatg acaggttgat gggtgcagca aaccaccatg gcatgtatat acctatgtaa 609840 caaacctgca tgttctccac atgtacccca gaacttaaag tataataata ataataaact 609900 tctttagtgc ctccagaagg aatacagccc tgctgacacc cttgagttca gacttctcat 609960 ctccaaaact gtaagagaat aaatgtgcat tatttcaaga gtgagaactt attccagcag 610020 ccacaggaaa tgtctacaac ctcctagctt tgttgcagtg tttgttcagc aaacctggac 610080 tgaacagtct ccacagaatt gttgaagagc tagcgctggg atgtgtgatg ggcactagac 610140 acctaccttt caggagttga cgggagagtt ggaagacagt tgttcagtca ttgtcagaag 610200 taataaagct gtccatggct tctcgcactg ttctcctcat gtgccttgcc tggtgacatt 610260 ggcagcctcc tctcagacac tagtaagatg aaacatcttt gtttcggtta tctgagtgta 610320 attaggtaga cactgactgc ttactgtaga tcagtcatgg tcccaagctg tttatccata 610380 ttaactcatt taataattat tcctccacaa tgatttcagt actattatta acctcatttt 610440 aaagatgagg gaactaatgc ctagggctca gttgacccca ggcttctatg aagcagagcc 610500 aggttgtgag tctgggcagc ctgacccctg gtgtcactca aaacccgtca tgtgctctgt 610560 gtctgagggc tgggtgtttc tttcctttga ctacagcacc tgagatctag ctccttaccc 610620 catgtatttg taccctggaa gtaacaccct acagaactgg aagttctgta cagattttgg 610680 aaggataaac tagcccacat ccacggagac ccaccagata gagaagagcc agaagccctg 610740 ggctatggtg accttacaac acggtgagcg tgagccagag ctccgatgct cttcagagtg 610800 ggcactttga gaagcatatt ttgacttatt cattaatcaa atgttgatta agtttcctct 610860 ttgggccaca ccctgggctc agtgcttggc atatcataca aagcaaggca acctgctacc 610920 tatacacaga aagcagtttc tagaatgcag gcaagaaaca tgggcagcta agttcaaggt 610980 ttagaattct tctttaatac atgcagctgc atcggcagaa acaagtttat atatttaagt 611040 gtgcagatgg aagcaagtgt acagaggaaa tttatttcca acccacagtg tttccaccct 611100 cgatatggta cttgataata cagccacatt gtacttcatc acctggggct ttggcaactt 611160 ttgttttagc aaaacaacct tacttttgaa taatagaaaa attatccatg caacagtgag 611220 ctttttttct tagtcccgtt gatgatacaa acatacgttt attgcatcta atgtgacgga 611280 gctctctcag taatgatgat ggctgttggt gcagtgtaaa gggacctgat tttttttttt 611340 ttctgaaaag gaatgcaagc ctggtgatgc atcatcatta acttcctagc tgcaatgtcc 611400 ttgggagtga ggccaaattt gcttgcagat gaatacagtt gaagaagtgt cgaatcaggt 611460 gatcctaagg ggtggagaag atacattttg aatggaaggc agtgtttggc cctcatgggt 611520 gtggtgccat tttctttctt ccgaatggtc cttgagaact aaattctgtt ttccattatt 611580 tcagctgagc tctcttgctg aagggggaca gggtgattaa agagctcaga aagagcccta 611640 cacagaccga agtagcagct ctcttagtct taattatcgg cctttatgta acattcttca 611700 aattaaacat acagcgaaag aaaataaatg cctccatatt ttgaaaacct gacagcttcc 611760 tctcttgtgt tttcctactt cataaggcaa aatgtgtttc ttgtagaggc tagtacagat 611820 ggttactctg gaccatacgg ttaactgata tgaaaccact gtctgttttg agtctcatct 611880 ttgtatttta tggtcaccat ctggccccct gaccatatcc caatgcctca gtagggctga 611940 aggtggataa ctccattgta atgtatcact attttcatag aataatataa acatttgctc 612000 tgctaatttt tgtttcttgc atgtagtgta gtagattctt taattacaca ggcaaataaa 612060 ttactcctaa tactattgca tttctgaaga ggctagtttc atacaaacga ggaagagctg 612120 atagtgatag tgatttttat taacaaggtc tgctatcatt gcagacatag ggcaactaag 612180 tcataatgcc ctgatatgct tacgaagatc tggagctaga cggagaccaa gaagcctcct 612240 gtgacctgcc tctaccctgg gcttcgggga tacatatttt actcacatta tatttttagg 612300 aaaaacaacc caggggaatc attcagggta catgaagttc tatcagcaaa aaaagaaaaa 612360 aagaaacata tccacccaaa gaattggcaa ctggatgcat ttaaatgtac caggaaggaa 612420 tgacagagac catgtgactg cagaaaagtg agagaagaga gaactggatc aagaacatca 612480 tagaataggc aaagacagag aggagaagca ggaaacagaa tgctgaggct acaatagaca 612540 ggagttagaa tggtcacaga attttcatat tccttatttc ccaaaagttc aagaaccagc 612600 cacatcttga ctcaacatta ccaagtatgg aaaagcacgt aatagcttac aatgatcttt 612660 tcttacaagt gccaggccca gtgggaactg ctttgcttat gtaatctcat ttatccttgc 612720 atcagcctct gaagtggaca tgaccatgat ttccatttta caggcaaagc aactgtgtgg 612780 ctcagagatg ttaaactact tgtccaaagt tgcagaactg ttctgtacca gagacgagtt 612840 gacttctgcg ctatgtagat cttcacaact tggatggtct tagtagaatt actcaaattt 612900 accttgaccc aggcaccatg ttgtccaaaa agtaattcca tgcctcaaga gtaaagtgaa 612960 aaccaaatca ctgttttaag accgatataa tattctgaga atgcagccat gttccgtgct 613020 agccagctct tcaggttcac tctgtgacaa gagctgttgt acattcccag catgggcctt 613080 ctggttaaga aggactgcag gcatcattag cctgggaact gagatttgca cagactggct 613140 gaatgaactg agtcattcaa cagccaaagc gaggcaggaa ggagtgtgca gaccttacct 613200 gaggctgtca gatgttgata cagcctggag ccatcttaac atgcaagaac tattactgag 613260 ccatgaaaaa gaagtgaatt ggagtgatac caggtcatgt ggaattgcta tgagttattg 613320 ctgcttggga aagtaaatgc cgagttgtgt gtagtagata ccgttctgtc aaatgaacta 613380 taaccaaaaa attgcgtatg tgtgtacatg cgtgtgtatg attgcagaga aaaatatgaa 613440 agggcataca ccaggttatt aataaagact agagggcagg gatgagcatg agggagtgtg 613500 tccatgtgga ggagaaggac agaaaggtgg acataggggc aaaaagtctc taattatatc 613560 aacagcatac gtaatgtgtt tccacttgtg caatattacg tgttgtgtgt gtgtgtatca 613620 tacataagaa catattgaag catggtcagt agaaatttga ccaaaattgc ctcagactgg 613680 ttggttgaat ttttagtgac ctttattttc ttcatcagat ttaagtatat ttgtttaggt 613740 gagttttttg gagcctgcag atgcttttga gtgaagaaaa aaatatattt aaaatattac 613800 ttggacttta atatggtcat ttattaaagt tataaatgta aaaaccctct ttttcagttc 613860 aacttataaa ttttgttatt ctatgtatgt atctcgtaaa tttaaacaag tactcttaag 613920 ggattttaaa aaaaactttt aggttcggga gtacatgtgc aggtttgtta tacaggtaaa 613980 ctgtcgtcac gggggtttgg tgtacagatt acttcatcac ccagataata agcataatac 614040 ccaataggtg ttttttctga tcctctccgt tatctcacgt gaagagattt ttgattaatg 614100 tttagaccca tttataaaca tagttcattt tcttctttat atattaaact acatttataa 614160 attatacata tttaatttcc tttttaaata ctccaattat ctaacagaac tgttctgggc 614220 atcttaataa cttataaata aataaacaac atgaataact tagtattatt atgactcctt 614280 aaatatcacc ctactaggtt taatctcagt aaaagtcctg cttagtatca cctgtctaaa 614340 ttgattactt aattatatat ttaaattaga attacaaata tgataaatac taatatgcta 614400 tatctcataa aaattacagc taaactgcac agatttctta ccataaaaat agtaatgctt 614460 ggggcttctt ctctaaaaca tctctgtatg gaattctaac tctttctgga ggtagaagac 614520 acttatctac tgagaaaaca tgaaatgtca aacagcttgg gcagtagctt tccgggcacc 614580 tttagggata ttttcctagt ggactgaggt ttcttaataa ccagagaagt cccttgtaga 614640 gacactgact agcatcttgt ttgtaaaatt caatccctgt ctgttctaag gtgtatcaaa 614700 gggctgtatc aaagcttttc ctatgggtct atcatacccc atgctccgta gattcataca 614760 tttattatct gtctcttatg gcaactcaca aaagccagcc atcccataac aggtggctaa 614820 gcctcttgat ttaactcaac aagtccattt ttggcttctt catatttgaa tttttctctt 614880 gtttctcctg tcttcagggc tgcaactaga aatagaattc aatcttagtg cataatgagt 614940 gacgtcatct gcctgtagtt acagttctag gtctgccaat gcagaagtag tggaattcca 615000 ttctgtaaac atgcactgtt tataaaatcc aaaaaaaatt actatattca ttgtggggta 615060 aacaatgata tttttcaagt agatatatgg gaacatttag atgattccta gaatgtaaga 615120 taaatattaa tcacctaaaa tgccaagggt ggtgtccaga ccagtttctc attgtgctgc 615180 tcaaatatat atcagattgg taaataaaat atttgatcac aaaagaggag gcattaactt 615240 ttaatttcag ctctgacaca tgaagagctt gtaggccatc attctcatct ttacaacaag 615300 aaaaagctgg aggccaggct gggtggctca ctcctgtaat cccagcactt tgggaggcca 615360 agacaggagg atcacttgag cccaggagtt ccagaccagc ctgggaaaca tgacaagacc 615420 ttgtctctac aaaaaataga acagtcagct gggcatggtc gtgtgctcct gtaaccccag 615480 ctacttggga ggctgacgtg ggaggatcac ttgagtgcag gaggtagagg ctacagtgag 615540 ccgtgatcat gccactgtat tccagcctga gcaacaaagc aagacactgt ctaaaaaaaa 615600 aagaaataaa agaaaagcct ggaaaaactg aaaatcaaca agttttctta cagagaactg 615660 aattgacaga gataaactct cacccggaaa tctagggaga taggtgtcac agcgagatac 615720 aacaacagag attggcttac ctggaacaga agctgctggg ccagtgaagt agcaagaaca 615780 agcaaatggc aattttggta cagtgttggt ggctgagtgt ggactggagt gagagtgagg 615840 agctcctaaa ggccaccgtc ttggggtcgt cctcacactt tcacagactt tctctctagg 615900 aaccttacca gattctcaca gtgaagatca aaccttctcc ataacaaagg tctactctcc 615960 acggaaaatt taaaaaaaaa aaaaaaaaac ctcttccaga accacattct gaaattttgt 616020 ctcacctgca agaaataaat tccttcccac tccagccctc tccagcctac ctatatgatc 616080 taagttgtga aaaaaaaaaa aaagcataat cgagagtcaa ggcttcagag aaatggattg 616140 ggcatgctgc agccagagaa cagagcaggg atgccgggtg ggggttgtgg ggacatctgt 616200 gtacctggaa gagaggcaga cacttggaag gacacggccc tgaaacacag gcccaaaaaa 616260 cactgagatt taatcataag tatggaacac tccccaaccc tcacaactta tgaccacaaa 616320 aaaatcaaac tgccagccaa tagcagaaag atagctgtaa aatcctctaa tatctgggaa 616380 ttaacacaac acactcttca gttatcccat gagtcagagc agaagtctca agaaaaattg 616440 aacaatattt ttaactaagt aaaaataaaa atacttatta aaatgtgtgg tttgcagcaa 616500 aagcagtgtt tagagtaaaa tgtatagcaa taaatccata tattcaaaaa gaagaaagat 616560 ctcagatcaa aaacctaagt ctacacctga gaaaactaga gaaagaaata aaagaggggc 616620 cactatgact ggtcccatcg actttaaaag gtcagtgctc acagatttga ttattcagat 616680 aaaattggcc aattccagaa gttaagcaaa gagaaactga taaactgaat agtccgattt 616740 ctattaaaat aattgaataa ataattttaa acctttcaaa aacaaaaaca gagcacaatg 616800 ttcagattgc ttcactggta attctaacaa acatttaaag aagaactaat accaatgctc 616860 cacagtctta cagaaaacaa aagcagatag aacacttctt cacccattcc attagtctag 616920 cattattcta atatgagaaa taaaaacatt gcaagaaaag aaaactttgt accattattt 616980 cttatgaaca tatgatgaca agtatagaaa aagatgctcg ctattattta tcattaggaa 617040 tatgcaagtt aaaatgacct tgaaatagta ctgtgcatct attagaatag ttaaaatcca 617100 aagatctgat agtatcaatt gctgacaagg atattaagta atagcaactc tcattcattg 617160 ctggtgggca tgcagaagta tagagccagc tcgacagttt cttacaaaac taaatacagt 617220 gttgtcttag gatccagcaa ttgtacacct gggtgtttgc ccaactgatg taaaaatgta 617280 tgtccacata aaaatctgca tatcaatgtt tataacagct ttgttcgtaa ttgccaaaaa 617340 tttggaacca atcaagctgt gcttcaactg atgaataaat acaaactttt gtttggtaca 617400 tctctcgaca gtagaatatt attcagctat aaagtagaat gatgagtcaa accactaaaa 617460 ttaagtgcat attaagggaa agaagccagt ctaagaaggc tggatactct atgactccat 617520 ttttatgaca ttctgaaaaa ggcaaaacaa tagagttcag aagcagatca gtggttgtta 617580 gggatttggg gaaaggagag gactgaacag gtgaagcatg caggacattt ttagggagtt 617640 gaggatatta tgtatgataa tgcaaccatg aatatgtaac accatgtatt tgtcaaaacc 617700 acagagcctt ccagcaaaaa gaatgaatct taatgtaggt gaattaaaat gtaattaaaa 617760 ttttcaaaaa aagcatttaa gaggtcatgg gaccccagga tgaaatggag actgtgcaaa 617820 tcaatctaat tgtattacaa atgagttaaa taactttact aattggatgc tgacctaagt 617880 aactttggag atgaatggaa gctgtatgac taaaggcaaa aagaactata cctaaacatt 617940 gcactctggt tgacaaagtt gtttctaaca gggacttact tctgaaacta ctatacatct 618000 aaactgtaat taaacaatta gggccctggg tggcagatca tgggagttgg gtttctcacc 618060 atgaagtggg agtttacaaa caagctaggg aagaggctag aatgagctgt gtggtacctg 618120 attagactta gagacatcag tacgaactca tgtttagctg aatagagata caatggatac 618180 atacaggaat attcatagat gtgtgtatat acatgtgtta gtatacacac attttttttt 618240 ctgtcagcta agagaacctg gaagcaagga acaatgccac agtagcaata aacacaactg 618300 tccccaaatc ttggtttcta ataggatttt ccaataaaat gaaccaggac tcctttgaga 618360 acgctaattc taagactggt aagggaatat aaaagaactt ggaacttcca agcacttgga 618420 acttcttgta gagttagaaa ataaagaagt accaagaaaa aaaaaaaaaa gaaaagaggt 618480 ggagggggaa agaaaggata aaataaacaa gcaatgatgg tgatacatca ataggatgtg 618540 ggagccacct gaaggagttc ccagtggtta aatctggaat catttgagca acagaacaaa 618600 taaggcggta ttggattata acccaaagtt taaaataaat acaccctgat aagtgtatca 618660 gtgtaaaata agtgataagt gtaaaataag cccacactga tataaatgat tgaataaatg 618720 gtaacaatag ccaaattttc ctgacgaaag aattccaagt aatttatgta gatataccac 618780 ctcaagaaga tgaagcataa ctctcactcc ttatgtgtgg gctttgcaga gcgacttcct 618840 tccagaaagg acgacatgga aagagaagct ttccagtgga gaaacctggc aggcaccacc 618900 ttagccaggt ggccaaggtc aacagcgaca ctgataagcc ctgttgatag catttaccct 618960 tgatatgatg tgatgagaat ggtactttac ctccgtagtt tgccccttca aaactctcat 619020 aacctcagcc taaaaatgag aaaaacaaca gacaagcccc aactgagagg tattctacat 619080 aattcctgac cagcattcct caagactgac agtcatcaag aacacagaaa gtctgagaaa 619140 ctgctacaga ggagcttaag aagacatgat ggcagaatgt agaatgggat cctggatggg 619200 atcttgaaac aaaccaggga cattaggtag caggtagggt catctgaaca atgtatgcac 619260 ttagttaaca atgcattaat agtcattcaa taattgtaac aaacgtgcca cactaatgta 619320 aggtgtaaat aatggaggaa ctggatgtgg agatgtgaag tatatgggga cttcctgtgt 619380 tattatctca acttttctat aaatctaaat gtattctaaa atgttgctta ttactttgaa 619440 aaaccaaata gaagagcagg tatcctccca ggtgtaccag taagggtagc agtgggggaa 619500 aggggtggta ctctgtagct acagacctca aaatacctgt atgatcttaa gacagagtca 619560 tcacatttca aattctgaga aatatcatgg gaagaacttg agacagctgc taggccttta 619620 gaaaacaatt taccccaaat gttgtctact attggtaaag tagcatttcc tatcagcctc 619680 agtcttgtga caggccacaa aaatgaccct tttccaaaga gttggttaac atgccataag 619740 atgcctgccc tgttctatct tcaggaaggt ggcagctggg aggctgagtc attgtgctgt 619800 gattctcaca ggatgcacct gtcttctgga aaagctcgaa gccttccaaa tgctttagtg 619860 ctgaattctc aggaatgtgg cttcagaatg ggccagagtc aaccatgaca cattttatcc 619920 cagcatcagt ctttgatcct taaatgattt ttttttcctc ctagagccta agaaactact 619980 aaagaaaatg tggtacatat atcatgaaat actatgcagc tataaagcag aatgagatca 620040 tgtcctttgc agggacatgg atggagctgg agaccattat ccttagcaaa ctaacggagg 620100 gacagaaaac aaatactaca tgttctcact tacaagtggg aactatatga ggagaacgca 620160 tggacacaga gagagtaaca agacacactg gagccttttg gagggtggat ggtgggagga 620220 gggagagaat caggaaaagt aactaacggg tactaggctt aatacctgga taatgaaata 620280 atttgtacaa caaacccccg tgacacaagt ttacctgcat aataaatgtg cacttgtacc 620340 cctgaactta aaataaaaat tttaaaaaat gttaaataat tgctgaagta taaacaacat 620400 aaatggcaaa ttaacttttg gattggttaa agatctatat tgctgttctt gaaagaggtc 620460 tctaaacatt agagaatgac tttgggttca tttgttacag cctgacacaa tgaggtcttt 620520 gtggagggct gcatgggttt gggacatttt gttgccacca ggcctcctca cttagctctt 620580 gtccgtatct atatttcttt catttcgtag ccaaatagaa aatatcattt taatatagaa 620640 tctcttctgc tgcttgatat ctctcccgac attaaaatag cacccctaaa gaaatgcaag 620700 gaagtgaact gagctattat caactcagtg ttcaagggag aaatttctgt ttcaatccaa 620760 gaaaatccga gaacccactg aattacaaag aattgtctac caagtaataa ataaaactat 620820 gtgttccaca tttgtgtccg cacattgtca ccaaactttc tgtgcatctt atctatgttc 620880 cttattgcag agttcactac catttgggga gaaagtcaag agcacaggtt ctgagggcca 620940 gactgtctgg ctttgtatcc cagctctgcg atgtactaac tccatctctt ccagccttag 621000 tttctccaat tgtacaacag ggatcataag agaacacatc tcattggata gataagtgga 621060 cgtgcaagag ttaatgcatg taaagcagtt cgtaaataag tgctatttat atgtagaaag 621120 tctttatcaa acccataagg gaatagatat tttcatgttg gaatcattgc ctttcagtgt 621180 gaaaatatat caatgtagtg atggttctgg gatcttggtc aatggtggag catcaccaac 621240 acacttgtgt ctgattccaa gaaggtgttg gaggacaggg ggactttctc tgccctctac 621300 tttcttctcc ccttagttca cacaaatcga ggctctgagg cctggggaaa agtattgtta 621360 cctttgtgtt ctctccatgg tcccaacaaa gatcgtgtgg accccagcgg taataggtag 621420 ggatagggaa gcaactggcc tccgggaata tagagacgtt tatcaacaag gtctgcacta 621480 tctcaggatg gatggcgggg cctcttaatc cctcaacctc ctggatgagg gatccaggag 621540 ggcactgttg agtccacaca caaagaaggg tggaggagaa gatgtcatgg cttctttcat 621600 atctggcagg attttagccg ttttgaagat agagaaggct taaaggttga aggtgggaaa 621660 attacaaatt gtagagtatt tgagtgggaa tgaatgtggg taaggggttt tgagaggctg 621720 tgcctgagat cgctggggga agaggctggg atggcaatga gcttctaaac acaaggcaga 621780 tgtcatgggc ttggtccaaa gggcaaggtg cagccgtgaa atgatggtca aggtcaagtg 621840 gttggggcag gtcttgtaaa cagaaatgaa ggcaggcagt aaagagaagg gaaatacaag 621900 tacgcatatg tgtacactca tctatcattc acaggcttac cttgttggca ggaggatctg 621960 agtctgagaa tgggcagtgt ctttcatgca gttggcctgg ccaatctcct gtgaacaggg 622020 atgtttcagt gtttaccagt acacaacctg agtgtatggt gtgtgtacct cgtgtgagtg 622080 tcatgtgctt caccttgtag catgcacagt acctccttga aaaggtagtt tctaattcaa 622140 accaacttac atttttatca agagtccata gagccaacta catgtgggat tgaatgttca 622200 ggtgaccgac aattcaattt aggacaaaac atggacttgt tatctttttt gaagtgtcct 622260 ttttaacttg aatattcact ggcatataaa tatgaaacgt aagatgtagc cttagagatg 622320 gttgtcccaa tagctgtcat ttgagaggat gcagtgtctc tgatactcat tttagaaaat 622380 atgaaagcaa atttttatgt ttatttttga ctattgtaaa atcttcaaat gcagatttaa 622440 gatgtcattt attgccaatt gttgattttt gctcatttgt gcatcaatat tagtttatgg 622500 aattgaattc tctttttgca acgttattga taattttagt gtatatagta gaaggctgca 622560 tttcccaagc agtctttccc catcatagag ctcttcccat cagtgtcatt gcctctagcc 622620 agacttctta tgtttctgat gaaatgtgaa agataagcat attcctgcaa ggaaaccgta 622680 attgttttca aagaggagca aacatctttc tttcatttct tctcaacatt cacttaaaca 622740 attgactaag aacaaaacta ccagagatgt gtaaatacca gagacattta aatattaaat 622800 atgatatcca tttatcacca gatttattct catttgcaat ttaaccagat cttgtttgaa 622860 atagtgttgg tgttcaatga tgcatgagtg ataatcaacc agttaatgaa agattatact 622920 gctttgattt cttgggggag aaaaatagac tgaatcatag gatatttaaa gagttcaaaa 622980 attctttttc agttaaaaaa tccccatttt tatacctagc cgaaggtttt ctcaattccc 623040 tagtacatac attgttatga cactgtgggt tattttgaga aattcatttt gcttcatcct 623100 gatttcattc attcttcact tctctgaaat ctaggaaatg caagtgcatt ccccagggac 623160 ccacagcatg tggggtgggg taggggtttc cagaagctct ccatccttcc tgatggaggc 623220 aaccatcaca tgggcctatc tgggcaggtg ggaaatatga gagggcattt ttgagcaccc 623280 tctctgtttt agagaggcca ttaaatgtgt tcacataagt gttgtcattc tcatactcag 623340 aaaccattct aaccttcata agtgaatgag agcaactttt tattaatgtt gtaactttta 623400 acaatttcac attgaaatat agcctaggca ttttattaga tcatgttaac aaccgctatt 623460 gatgacttaa aagacaaaaa aatctattta gatagataca tggatgtgtc tgagcatgtg 623520 tgtttctaat tataatgtgt atatatgata tgactgtaga aaaaaaaggt aacttagatt 623580 ttcgttaaag atgtttaaaa atactcttct ggttctgaga aaagctgtct tcctattgga 623640 gcttttttta cctgtgttta ggaagcccat atgtcatgct gcaagaaaag aatgtgttta 623700 agagctgaaa atggcatttc ccttaggata gtagcagctg gaatgaaagc ggtgatgatg 623760 gcaagttcaa cgtggctcag aaatgacttg aatgggggct ctcaggctca agtgatgggc 623820 tggtctctgg gttgcaggac taaggaccat gttcaggtgt tacctggggt tcagggccct 623880 gcagcctggg gacctcctca aagctgctct gagggtgagt ctcaggaggc aactccaatc 623940 ctgcaccttc ctcttggctc ccacatcggg agcagggact gagggcaggc tgctgggcag 624000 gtctcctggt gtcaggaggg gaaagagagg ccacaccgga cacacctgag aagggaacaa 624060 aggttggtag ggatgctgga ggggagcgtg gtcatgggta aaagaatatt gagcaaagaa 624120 catttccagg gattaaagtt tattatattt gcagatttgg ccctcattct aagaaacttc 624180 cattagactt tagatcttta atacagatca gtatagattt caaactttaa aattgtctca 624240 attatataga aggacacttc tcaagatttt tgatcctagg accactttat aatcttaaaa 624300 attcttgaag attccaaagg gcttttgttt ctgtgggttg gatctatcaa tatttgctgt 624360 actagagatt acactgagat atttttttaa atgacaacta tgacatatta tcataaatat 624420 acttcttaat aaactatttt tagaaattgg tgagaagagg atgaattatt ttacattttt 624480 tgaaaatctc tgaagtctgg cttgtagctg cttctgcatt caatctactg tgatgtgtta 624540 tgttcgttga agcatatgaa gaaaatacaa ttcgcacaga ggtgtagttg gacagggaag 624600 cttaatagca ttttcagatc atcatggcta ttgctctttg atactctacc aaaatttggc 624660 aagcggtggt ttttaaagat taattcccat gcagaaccaa aaaccatatc aacagccttt 624720 tcctacccta ttgcattaaa atatatcagt gtttctggat cttttacaca tgcatgattt 624780 tataacacca tgcattggtt tttggaaagt atttattcac ttagtaatgt agacgttcca 624840 aatgttgatg cactccatta tacaatactt ttgaaaatca catttataat atcactacta 624900 atgtcatcca aaatatcttt aaatattggg aaggtgtgtt aagcatgtgg tgaagaatcc 624960 aagttttcta aaatcgaatt aagacttaaa agctcaaatt ttaccactgg caacaaacac 625020 tctcagttgt ttcccttgaa gtgacaggct cacttcattc cttttgagaa aatgtttgtc 625080 aaatacccag acaaaaatag tttatcagtt tttctttcaa gtagaaatgt gttccatgaa 625140 aatcacagct gatcagctca tattcagtcc cacactggag cttttcttga gcacccaaca 625200 cacaggtgct ttgtatgttt ctgccattct gtcacacaga atgttaaaaa cgcacaccct 625260 caatggttga gatggaatga aatgaaatga tttccactgc ttagtcaagg acatgctgaa 625320 gtgaagctgc cacgtttgtt tttgttgcga gtgttgacgg acaattgtga agaccacaac 625380 ggccgtgaga agagtttggt gccactgcct tgaatcctat taaggcccca gcagatttgc 625440 ccactgttgc ttttgtactg ttggctaaaa aggcaaataa ttttttagtg ttattctgaa 625500 aatagctctg atctcacaga tcctttgaaa aagtatcagg gatcccaggt gttgttggac 625560 tgtacctgag atcagttgat acaaaacaat cttatgatta ctatttatat gtatattata 625620 tataatatgt attattttat attatgcata tcatatatat tttatgttat ttatataata 625680 atcctattac gtatgtatat tatatattta tatattatac atatatgtat tatacacgta 625740 cacattatta tacatataaa tatacatatg aaataatttt tcaggttatc tagatcttgg 625800 atctgagtaa tccaatcagg tgtctgattg taatgccctc tgcaggctgg gtagtgtggt 625860 ggtggcatgg gtgggacagg tagtgtagtt ctgggagaga tccgtctatt attcatggtt 625920 tcactctact caactctttg aggctctcaa ctctttttca tcctgtttga cactccacaa 625980 ctcttgcata ataataaaca gaggtactat agtcaggcaa aaatgaattt aaatccttac 626040 tttgcttctc actagccatg tgaattgtag caggtttctg agcacctctg agcctcagtt 626100 tctgcatctg tgaaatggag ataatacaaa gctacctcct aggatggttc agagattaat 626160 gaaattaaaa cctccattga tggagtgacc tcagacaaca cgttgtaaaa gtaagcttgt 626220 gcagcctcgt ggcccagtga gcacagtgat gagcgcagaa ggataaatga ccaccttttg 626280 gttgggtgct agggtgagcc tgctgcattt cctaccgctt ttcacacatg cacaatacct 626340 ctatccacct tggaatacaa ggaaataaat tgtgtcctgc atctgtttct tcagtcacag 626400 ttaagctgtg aactctcatg gggagtctca tatagctatt ctaatacatc ctcatcactg 626460 tgtggcacca aaattgtgga gactttttat taaagattat acagtgttag agtttatcat 626520 agcagagttt gcataacatc aaatttcttt atagtctatt tatgtaccat ggaggaaaac 626580 cattttaatt aaaaagtggg ataagctaat ttatctcttg aataccaaat gtcttaacct 626640 caaaacccag gctaaggtta ttcttacaaa tacagaatgt tttcagagga gacaaaatag 626700 tgaattcagt gaatattttg ttgtacagtc cattctgtat tttccttcta cattttattt 626760 attaagtcag acatgtatat tcactttaaa tgaaactctt ctaatgcttg acttggctac 626820 gtttggaaat agccactcga ggttggttca tggagaaaga ggtagctggc cacacacaga 626880 caatgactct ccctcaagtg tacacaaggt gctcacatct tcccaaagcc tgcttccagg 626940 accccaggcc acagtggatg tgagagagac aggatgtcat gttgaaaggc agttttatat 627000 tgctaaggct cccataacac agttaaaacc aaagatcaaa tctaacctgg caaaacgttg 627060 aaaacagttt acagctgttt gttagaaaaa gttaagccat taactcctta gatagccttg 627120 attcccgttt tctttttgtc cacagctatt tagtatcttt tatggaagta tagaatattt 627180 atgtctgaac tgcaccaaac atattcaaaa atgctatttg gtgtatatat aacaaaagta 627240 aacatatgta agatttctac ctgttggcat ttgtattaat ttacaaacat ttatgaagta 627300 gaatgctact caaaaaaatt catttaactt cacttgttgg ttattggttt tattaataaa 627360 catatagaga aacaaaataa atgataatat ggaatattgg cagagatgca caaatattta 627420 cattctgata tatcatttgg caggaaaatt ttttaaagca atttgacaaa atatatcaaa 627480 agccaaagac agttaatgtc ttttgactca ttaatttcac ccttaattat ctataccaaa 627540 gaaataaaag ttatagacaa atatttatgt agaaagagtc aagacagaac tttaaaataa 627600 taaaaaattg tttctctcta aatagcttaa tgaagtgact gcttctgtga atggtggtgc 627660 atcagcctaa ttcaatatta tgtggtaatt ttaaattatg ggtttaaata agttttctta 627720 atataggagg cagtcgtata atatagctgc atttttaaaa agcaggattt gaccaccatg 627780 atcaagtagg ctttatctcc aggatgcaag gttgattcaa catacacaat caataaatgt 627840 gatttatcac ataaacataa ctaaagacaa aagccacagg attatctcaa tagatgcagg 627900 aaaggctttt gataaaattc aacactcatt ccatttcaaa actctcaata aactaggtat 627960 tgaaggaaca taccttaaaa taataagagc tatatatgac aaacccacag ccaatatcat 628020 atggaatggg caaaagctgg aagcattcac cttaaaaacc ggcacaagac gaggatgccc 628080 tctctcactg ctcctgttca acatactatt gaaagtccta gctagagcaa tcaggaaaga 628140 gaaggaaata aagggcatcc aaataggaag agaggaagtc aaaccagatg acatgattct 628200 atatgtagag aacttcatag tctcagccca aaagattctt cagctgataa acaacttcag 628260 caaagtttca ggatacaaaa tcaatgtaca aaaatcacta attcctatat accaacaaca 628320 gccaaactaa gagccaaatt agaaaggcaa tcccattcac agccacaaaa agaataacat 628380 ttctaaaaat accagctaac cagggaggtg aaagatctct acaacaagaa ttacagaaca 628440 ctactgaaag aaatcaggga agacacaaac aagtgaaaaa aaaaatccca agctcatgta 628500 taggaagaat caatatcatt aaaatggtac tgccaaaatc aattcacaga ttcagtgcta 628560 tagctatcaa actacaaatg acattcttca cagaactaga aaaaaatttt tgaaattcat 628620 atggaaccaa aaaaagggcc tgaaagccaa agcaatctta agcaaaaaga acaaagctgg 628680 aagcatcgcg ttacccaact tcaaactcta ctacagggtt acagcaacca aaataccatg 628740 gtaatggtac aaaaacaggc tcatcgtcca atggaacaca atagagagcc cagaaataag 628800 gtcacacatc tacaatcatc ttagcattga taaagctgac aaaaacaagc agtggggaaa 628860 agactcccta ttcaagaaat ggtgctagga taactggctg accatatgca gaagattgaa 628920 gctggacccc tttcttacaa catgtacaaa aatcaactca agaaagatta aagacgtaaa 628980 acccaaaacc ataaaaaccc tggaagacaa cctaggcaat accatcctgg acacaggaat 629040 ggcaaagatt tcatgaaaaa gataccaaaa gcaattgcaa cacaagcaaa atttgacaag 629100 tggaagctaa ttaaacttca gagcttctgc atagcaaaag aaatgatcaa cagagtaaac 629160 aacctacaga atgggagaaa atatttgaaa actatgcatc tggtaaaggt ctaataatca 629220 ggaacttaag caaatttaca agaaaaaaac aaaccacccc attaaaaagt gggcaaagga 629280 cgtgaacaga cacttctcaa aagaagacat atatgtggcc aacaagcata taaaaaaatc 629340 tcgatatcac tgatcattag agaaatgcaa atcaaaacca caatgagata tcatctcaca 629400 ccagtcagaa tgactttaat aattttatta ttaaaaagta taaaaataac acatgctgga 629460 gaggttgtgg agaaaaagga atgcttatac actattggtg gaagtgtaaa ttagttcagt 629520 cattgtggaa gacttgagtg gggagagtca gaggagggag aggagcagaa aagacaacta 629580 ttgggtactg ggcttaatac ctgagcagtg aaataatcta tacaacaaac ccccataaca 629640 caagtttacc tatgtaacta aaccttcaca tgtaccccaa acctaaaata aaagttaaaa 629700 aaagcaggac gtttgaaaag tatatgtata catatatgta gtattatgtt gacaaggctc 629760 agaaatcata tctttttaga tagaagaaaa tgtgcttgtt aaaatggttg cttctctcag 629820 tattacaatt atgaatgata tctttctatg cttttttata cttttctgca tttttcaaac 629880 cttctgcatt aagcttctat tcatttgcaa tcagaaaaat ataatcaaga aatgtaatac 629940 aataataaga tatatacata gtcttctgag acttcaaata taaaataatc ttgaaatgat 630000 gaaaatcttt gtcatggcat ttttgagaaa gggataacag atattctctt ttagaaagcc 630060 aggttgtgtt ttagagtttg aggagagaaa tctgtccact ggtccctttt ctggcctggg 630120 aatggaatca ttagttgtgt tcagtttttc agacacagcc atctttgttt tctacttagg 630180 gtgaccgact ttgaaaaata atgcaaatga catgagattc tcggccaaga aaagacattg 630240 gtcacttagc cctgccaagg tgtcctgtct gttccatcac attctaacag ggcagcagct 630300 ccagggggga ggtagggcag tggctgcctt ctcatggggg cactggttgg ctgcgggagg 630360 ggcctcctgg ccttactgct gggtgttacc tgtgctgctg tgacaacagt ctcatctgcc 630420 aggtgcaaaa tctgctctat gatgaacaat ttaagtgata ttccttgtgg ttgcataaat 630480 ctagtttaaa cagtattgac attttcctat actcacagtt ctcactttgg ttttgtaact 630540 gatgatgcat taataggtgt tgattataga tatccatgta gataagccta tgatttctat 630600 caagattcta aaatagacgg actttgcctc tagaggtttt taaaagcttt ttttataaag 630660 caaccagttt aatataaatt tcataaaaaa atggatcatt ggctgggtgt agttgttcat 630720 gcctgaaatc ccagagcttt gggaggccga ggtggaagga tcacttgagg ccataagtta 630780 aagaccagcc tgggcaacat attgaaactc tgtttctaaa aaaaaaaaaa tttttttttt 630840 aaattaggca ggcatgctga cacatgactg tagtcttagc tacttgggca gacggctgag 630900 gtgggaggat cacttgagcc caggagtttg aggttgcagt gagctatgat cttgcacacc 630960 agcctgggtg acagagagat cctgtctcta aaacaaatac aaaacaaaaa gggctcattt 631020 gttttatagg aggccaaaag aaatcattgc atgtcttgac ttgcttagca cttattctga 631080 agaagaaata ttggcgtgaa atgcatgttt ataactgggt ccttcccata gtagtcttga 631140 gcacaaatac caaagttgtt tttttttttt tttaaaggag aagaaaagga gcagtttcac 631200 cttttttata cagaatgtag acaaaatggc agtcatttat gattgatttg ttctacctac 631260 ttagcatgca gggactcccc agtgtggttt ttaaattaat tagttaattt ttttctttca 631320 ttagttttaa tggtacaagt ggtttttggt tacgtggatg aatcgtgtag tggtgaagtc 631380 taggatttta gtgcacgcat cacccaaata gtatacattt acccaactgc tagtttttca 631440 ttcctcacct ccctccccac ttctgagtct ccaatgtcca ttacaccact ctgaatgcct 631500 tggcatacct atagcttagc tcccacttat aagtgagagc atgagtacct ggtttttaat 631560 tcctgagtta cttcacttag aataacggcc cccagtttca tccaagttgc tataaaagtc 631620 attatatttt tttttatggc tgggttgcat ttcatggtat atatatcaca attttttctt 631680 tttgtttttt tttagttgag tcttgctttt atgatttttt tcctttccaa ctgttatttt 631740 aggctcagag ggtacacgta caggtttttt acatgggtaa gttgtgtatg aaccacattt 631800 tctttatcca ttcatggatt gatgaggact caggttgatt ccatatcttt tttttttttt 631860 tttttttttt tttttttttt ttttttttga gacggagtct cgctctgtcg cccaggccgg 631920 actgcggact gcagtggcgc aatctcggct cactgcaagc tccgcttccc gggttcacgc 631980 cattctcctg cctcagcctc ccgagtagct gggactacag gcgcccgcca ccgcgcccgg 632040 ctaatttttt gtacttttag tagagacggg gtttcacctt gttagccagg atggtctcga 632100 tctcctgacc tcgtgatcca cccgcctcgg cctcccaaag tgctgggatt acaggcgtga 632160 ggattccata tctttacagt tgtgaattgt gctgtgataa acatgtgtac aggtgtcttt 632220 ttgatatact gattgcttca agaacttagg aactctggag tttgatgcat atatatttac 632280 aattgttaca tcttcttgtt taattggtca ttttatcatt atatagtgac ctttgtcttt 632340 ttcttgttgt tttttgtttt gttttttttt ttttttttgc tgttgttgct ttgaagtccg 632400 ttttatttga tatcagaatc gctactcctt gtttttggct tccatttgct ggaaatctct 632460 ttttccaccc tttacctgta gtctataaga atccttacat gttcagtggt gtttcccaaa 632520 gacagcggtg taggctgcta ctcacagctt ctttcaaagc tgtttacggt cctgtgttcc 632580 ttcttggaaa aaagttcaca gtgtgaatct ctacacacta ttttatcttt ccaagtggaa 632640 aaggaatgct aacaatgcct atattccatc atcttggaaa aacaaaacaa caagaaaaac 632700 ccaatgtaaa tattatcagc acagaatctt tctttatagg ctccaaaata taccagatgc 632760 acacttcata ttttatcttg attacatatg ccactcttta gagtctcagc taactatgac 632820 tgagtaagaa tgtcttagaa cacaggctcc cacgtccatg agtgcattaa atattcttat 632880 ttccaaagtg gccaggctgg ctgatagcta tgactagttg gagagaaagc agcatttata 632940 gcctaagtgg gctgggcaac aaactacctg aaatccttag gagcaagaat agaagggatg 633000 ccttgttctc tacacccagg tatcactcat tgcctgatgt ctcgcttcgt gtgtttgctg 633060 ggtttccgtc tgtctaggaa aggaagctct atgggggcaa tgactccaat gagtttgtct 633120 ccctttattc ctcaccatgt aggtgtggat ttgagtggac tccaaatggc tgggccaagg 633180 gccttggata ccaaacacag cagaagatgc ggaaaggatg agggacccag gggttctgtc 633240 tttgggggaa gagccctgtt ccctggacat tgcctcctta tatccctgca ctagaatatc 633300 gtaaaattcc cctagtcaaa acccatgatc ctgcatgtct tggagaggct gcctcaagga 633360 ttcctccttg actccactta ttttcatgga gaaggaaccc ctccatccct ggcatcctta 633420 acagattccc ttctagcttc tcacccactc catctccaag ccaggtttcc cttcgcttct 633480 agaaataatc tgcagtggct gcctaagatg ttttctgcgt ggaacccaaa taaaaatgta 633540 ataatttaaa ttagaatttt ctacaatcat gtgttgctca tgtctgcatt atggataccc 633600 aggtcacatg taggtaagca attagcaatt atggtggaaa caagacttcc taacaggtat 633660 tttggtggaa acttgaaagc tgtttctaaa gctgtttatt catgcaaacc tcattacagt 633720 cctgacagta aacctatgtg tgcacaggga ggcaggaggc tgtgaggcag cagcaggatc 633780 cttcacccca tggctcactc acagtgcact ctttaaccag gtcttattat gtccatgctt 633840 ctggggtgat taaaatatgc cctagaagcc ttgataccca aaataaagca aaacgtggaa 633900 tatgaagttt aaaaatgtga aataataagt aaaagttttg tgaaatacat ttttctatac 633960 tgttcaaatg atcttgaaga tggcatccgt ttcttaggtc tgccatgcaa aatgaccacg 634020 atggagtggc ttaaaacaac agacgtttct tctctcacag acatctgaaa tcaagaagtc 634080 agcagggctg gtgccttctg gaggctctga gggcacatca gttcctcacc tctcccagcc 634140 tccagaggct tcctcaaccc ttcacactgc tgagcctgtg gctgcctcac tccagtctct 634200 gcctccacct tcacatggct tcttttttgt gtctctgtgc cttctccttt tctgtctctt 634260 atatgacatt cttcagtgga tttaggaccc accctaatga aggatgacct tatctagagg 634320 ttcttacttt ctttaactct gcaaagactg tatttccaag taaggtcata ttctgagatt 634380 ccaggggttg ggatgttgat atatttttga aggaccacaa ttcaacccac taaagggatg 634440 aaaattaaac tgaaaaatat caacccctaa aaaacctgct ttattgccaa ccatataaat 634500 tgctctttgt cacaatatac aacagaggcc tcacaaacct tggtgttctt ggtgtgagaa 634560 tggtgaaaaa caagatagaa agcagcctga aatatgcaca ggggtgtgtc atctcgttac 634620 tgggaaagga tgtactgtcc aagcgacaac tagactgcag aggtaaggct gagaccaggg 634680 ctgccatggt gtttagattg aacatgaagt tagaattctt aagtatcaaa actaaattca 634740 tgttcaatct aaaccccatg gctatgcctc tcaaggtgag gcctctgtgt tgttctctat 634800 gccttgagca cccttccttc tttgcaataa aaaaagttgc agaattgact gggcacagtg 634860 gctcacgcct ataatcccag cactttggga ggccgaggca ggcagatcat gaggtcagga 634920 attcgagatc agcctggcca acacagagaa accctgtctc tactaaaaat aaaaaaatta 634980 gccaggcgtg gtggtgcacg cctataatcc cagctacttg ggaggctgag gcaggagaaa 635040 tgcttgaacc tgggaggcgg aagctgcaga gagcagagat tgggccactg aactccagcc 635100 tgggcaacag agcaagactc cctcccaccc cccacaccaa aaaaaaaaaa gcttcagaat 635160 ttcagtctcc cacaacaaaa cccacacaca cacaaatttg tgtagcagct actatttgcc 635220 aacaattagg gtctacacaa ttaagacatc atctttaacc tcaagcagtt tacaatccag 635280 agggcaatga tggaggagaa taatgaggtg tggataaaag tgcctattag cagagtatgc 635340 agtggaaagt gtgataacac ttctagatag aaggcagttg gtccataggt attttggtga 635400 gaatctacat gtctgatgca tcatgggctg taccaaggac aagtcactgc ctttggaaat 635460 gtttgactca tgccctgatg gataggtgga taggtctaca catcaaaaat gcatgcctgg 635520 ctacacattt atgagaacaa caaaaatttt ttaaaaatta taacgccaca tgctggcaaa 635580 gatgtggaga aactggatct ctcatgcatt gctggtgggt atgtaatatg gtgcagacat 635640 tctggaaaac tctttggcag tttctcataa aactaaacat gcacttacca tgtggtccag 635700 caattgttct cttaagcatt tatcccaaag aaatatgaat ttatgttcac aaaaagttat 635760 ataaaaatat ccatagcagc tttctttata gtagctaaat tctggacaaa cagcaacaac 635820 aacaacaaca aaatgaatgt ttctcacagg tgaatggttg aaaaatctat ggtccatcca 635880 tagtttggaa tgctgctatt cagcaatcaa aagaaatgaa ctgttgacac acacaataac 635940 ctagatgagt ctgaagggca ttacgcttag tgaaaaaaag ccaacttcaa aaagttatct 636000 ttataaagca ttctcaaaac gataaaacag cagaggtgga gaatacctta gtggatacta 636060 gtagacaggt acaatgggta ggatggggcc aggtgcaaac acagacagat aggaataagg 636120 aattcttctg tggtgtggaa tagttcctca tttgatggtg gtggtgggta catggacctg 636180 taatgggata aagttaaacg gaagtataca cctacagagc tacacgagca catacacaca 636240 aatgaatgtg ggttaaaaat aatgaaggtg gccaggtgca gtggctcatg cctgtaaacc 636300 cagcactttg agaggctgag gaggatggac cacctgaggt caggagttcg agaccagcct 636360 ggccaacatg gtggaaccct atctccacta aaaatacaaa aattagccaa gcatggtggc 636420 acatgcctgt aatcccagct actggggagg ctgaggcagg agaatcattt gaacttggga 636480 ggcagaggtt gcagtgagcc aagatcgtgc cactgcactc tagcctgggt gacagagcga 636540 gaatccatct taaagaacaa ataaatgaat aaaagatgaa ggcatctagt ctactggata 636600 atgttaactg ggaatgttcc catgtgggtt tcctggctct gatattgcac cacagctatg 636660 gaaattcaca acatggccag aagctaaagg acacacagga ctctactatt tttgcaactt 636720 cctaggagtc tgtattgcaa aactttagct ttgtaaaagt aaatgccaaa agatatatat 636780 gtgcaataaa tgtgaatata tacattaaaa agttgtggga gtttggagaa gggagagccc 636840 cttgtagggg tgaggtcagg gagggctcca tagaggaggt aggacgtgag tttaacctgg 636900 aaggtggaat gaaatccaac ttgaagaact ggaggtaatt ttcagaatgg caaaacagtg 636960 ccagccagtc atacctggaa aaggaaaacc atgttctcag acctcaaaat agggaatggg 637020 ggaggtggag aaacatacaa ggtatgtttg agtgctgggg tggaatgtct gggtaaagaa 637080 ggagttagtg ggtaactgga aacataggtt gcagcaagat tataaaacgt cttaactttt 637140 aagctgtgaa aactgagctt aatctgtaaa tagcaggaag acattgtaaa ttgcaagtga 637200 gaggatatca tactggaagt tgcatgtgag gaagctgagt ctggcagagc cctaggatag 637260 actggagtgg aaaaggaaga tgaatgagcg atgagttata atgccatttc acagcccagc 637320 acaggcatcc tgattatggc ttgcagtaag ctgatggtca cgggcctaga ggggacaagt 637380 ctaatttaaa tgatgctatg aaccttgacc aagaaggacc aggccactga ttgccttggg 637440 gacctggaat ccatccaagg aggagcctgg gacaggaata gggacaggga gaaagcttgg 637500 aaggaaaggt gccacatttc atctgtctca tgttgattgt aaggggatgg tgtgccttcc 637560 aaatggaagt acctggctga cctccagaga tgggagacag cagctcagga gagagtggtc 637620 agggctttat aagaaataat cgagacagcc caagcaggtc agatcagcaa gggtaagagt 637680 ggaaaagaga gcagaagagg aagaacagaa atgtaggagt cttgtgtgtg caggcatcgc 637740 catgcaacgt ctatgaaatg agtagtttct cacttcatcc agtcttcttc ttggcatttt 637800 gctcaaagcc tggcattata ctggacaggt ccagggttgg ccacacaccc tgcataacct 637860 tctcactcat cctcccccac tgcttcctta acaacctcct gtcactcact gtcatcaagg 637920 cggaagcatg tgcacttcac ttcatcaacc atggcaacca gctctgagag tcccaagtgg 637980 aagacgatga ggggagaatc actcattgtc ctcgtggcta caggcagcct ctctgagccc 638040 acagaacctc acccctacaa ttaatcctga atgcgagttc tcaaaatagt gcccgctcat 638100 ttagctgtca gctgtcttgc tcttagagct tctgaaaaga aatcacaata gctcagacct 638160 catctttgag gggctgtttg ttttgagggc tttttcctta gttgcatgct tcctattgcc 638220 agcaaaaatt tcttaatctt cctagaggat cagattggcc tgttttagat ttttaaatga 638280 aaggttaaga ggagggagga gtagggcagt gaaagccgca gctgcctctc catatttctg 638340 tttcgcaacc caaggggatt ttgtgtaggg ctaaatggaa ccccctacgg ataacagtta 638400 tgtcaggaga tctttctgca tgttctcgtc atactcaaaa tgttccttca catgtaagtt 638460 agagaggaca tgttacttct ttccccagct gtttcctggt gagtaagaac tcctgaccat 638520 gtgagaatat gagagcatgc agcactccaa gatccttggg gaaaacaatg aaagcaacag 638580 ctcagtgagc cattctccat gctcaaccga aaaccctttg agattcgctg ccactttctg 638640 tgacaatgga attgtggccc ggtttagccc agaaatgtgt tgcccaggct ggagtgcaat 638700 ggcgcaatct cagctcactg cagtgtctgc ttcccaggct cgagctattc tcatgcctca 638760 gcctcccagg tagctgggat tacaggcacc caccaccaca cccagctaat tttttgcatt 638820 tttagtagag atcaggtttc accatgttgg ccaggctagt ctcaaactct tgacctcagg 638880 tgatccaccc acctcagcct cccaaagtgc tgggattaca gataagagcc accatgcctg 638940 gccagtgctg ctcaaatttg aaccaggaat atttgttgat gggaacatac actaaatcta 639000 ttactccatg gattccattt ttattccatt gataatgtat tataggtatt attaggaact 639060 aacttgtgtc tccccctaaa attcgcatgt tgaagccgca actcctgctg tgactgtatt 639120 tgaagataga ggcttaaaga ggtgattaag gtaaaattag gtcctaaggg tagttctcat 639180 ctaatctgac tggtgtcctt ctaagaagag gttagcgtgt agccacacac atggaggagt 639240 gaccgtgtga ggaccccagg tgaagatggt tatctgcaag ccacggagag aggcctcagg 639300 aggaatcaac cctgtcaaca acttggtctt ggacctcgag cctccaggac tgtgagataa 639360 taaagtccta ttattgaggc caatccatga taatttatta tggcagacct agcaaatgaa 639420 cacagatcta tctttctgag actttacatt atagtttttg tgttttaggg gctgaataat 639480 atgccactta tagatgtgta attacttttt aagtaactgt gaacatttat gttgtgccta 639540 aaggctccta taatcaataa gattgcaatg agccatcctt atacataaac tatgcacatt 639600 tatctaatta atttcctagg ataaaataca agaaaaggaa ttacagggtc aaaagatctg 639660 ctcacacaac atatttttac acctggccaa actggcttcc cagaagactg taccatcaga 639720 catttccatt gcaagactag agtgccagca ccccagtccc cacctcctac caaactggac 639780 actttcagtc atctgctctg caatggcaag aaaatttcac agaaattaaa gaaattatag 639840 aaagaatttg aatatcttgg tattttaata ttgaaatttc catttgttta atgaattctc 639900 tatccttttt cactttttct gggattgttt ttagtattta taaatttatg ttattgcata 639960 ataatacttt tttactatag ttacaatttt ttttcggttt gactttttaa aaattttgtt 640020 ttccatattt atttgtttgc atgtttattg ccatacagaa tctttagcag gatgcattgt 640080 caaatctgct aagcactatc tttgtggttt ctatcctggg gtatcatgca tgcaatgtct 640140 ttcttttctt gaaatggaaa ataaatcacc taaattttct ttaaattgtt tttgttttgt 640200 tttgagacaa agtcttgttc tgctgcccag gctggaatgc agtggcatga acagagttca 640260 ctgcagcctt gacctgttgg gcccaagggg tcctcccacc tcagtccccc agctagctgg 640320 gactacagtc atgtgctacc atgctcagtt atttattatt ttatttttgt agagatgggg 640380 tcttgctatg ttgcccaggc ttcttttgaa catttttttt tttttttggc aaatcccagg 640440 aaaagcaagg attagaaatg tttactacca cattattggg atttttaaaa aataaaagca 640500 gagttttaac ttacttgata taacacatcc aaatagctat gtggaaatgg cccaggaaat 640560 atggttgatg ctggaggcac ccattcctct cactgggtct caatgtgtgc cctcctccac 640620 cacctaccca gctgtaccat tgtacctcag gaacatgtag aatgtgcagc ctctggagtc 640680 ccccctagac ccactgagtc agctccacag gtcgggccta cccccgtgtg ctaacatgcc 640740 ctccagagga tgctcacagc ctctgctctg ctacccagag ctgcctcctt gacccctggc 640800 ctcaggtgct tttccccagc agtttccagt ggattcatcc tcacatcctg ttcctgtcat 640860 tagggacaca cctactggga tgaaggtatt ctggtgacag ctcatttgct attcacacag 640920 gcacacacag actcacacgg gtgttcaaag gtctctttac ctagacgcac tgacattact 640980 atccttagaa ctgggtggag ttcagagaga tacagttaga gcacaggtta cacgttgtgt 641040 cagatttcac agttccctct gctttgggca tcccaggctc tctaagagga agcaggtgct 641100 gctgccaatg ccaaaaagcc tctgtgggtg agatagttcc atgtcgaata taaaaggcca 641160 aatgtggtaa aacctccaat acttattgca taaatcctcc ctaaatggga tggagagagc 641220 agtgcaacaa tctttcttca ggagaaacta taggtgatgc ttttaaacat tatttactat 641280 ccttgaatgt ttttgaaaca tgcttaaata tcttatatgc ctgttttata tgtgcatatg 641340 gggaaatata caatataata ttcaccgagg caaagaattg gggacatgat caaggagata 641400 tttttaatac ttcaacagat cattttttgt ggctctttag cttgggacct tgtgctgtga 641460 gaggcacaag tttctgtgtt caagagaaca cttttttttt tttttttttt tgagatagag 641520 tcttgctctg tcacccaagc tggagtgcaa tggtgcaatc tcagctcact gcaacctcca 641580 tctcccgggt ttaagcgatt ctcctgcctc agcctcctga gtagctggga ttacaggcta 641640 ccatcaccat gcccagttaa tttttgtatt tttagtagag atggggtttt gccatgttgg 641700 ccggtctggt ctcgaactcc tgacctcaga tgatctgcct gccttggcct cccaaagtgc 641760 tgggattaca ggcatgagcc actgcaccag gcccaagagt acacttactt gcatgaagga 641820 gcagtgaatg aaacctgcta aggcccccag catgcactgc ttggcagcac tcatcttcct 641880 tggagctgaa tcttctagca ggtttctgct tcatttagag ccgtcaatac ctcaattagt 641940 gtctgttcgt ctcccctggg agggaccttt acacatgtct cttcatgagc ctctgaactt 642000 taaaaacccc ctgagagttg ctgggtcata aaatacctcc tgattaacag tgctgtttgc 642060 caacaattcc ttgctccttc catttccccc ttcttaaaga tgtatcaact gacataaaca 642120 gaagacacag aaggggtgca gcctgccaac agttacatgg aatgtattcc tgcaaatgtg 642180 ccatgcatct gtttacccat ttcactgctg gatgcagggc tcataagccc ataacacaaa 642240 gcaggaaaaa gcactggttt tagttgcaca tgtgactgtg tgtgtgcatg tgcagacaca 642300 cttgcttgtg ttggcattta ctcgaaagct aggatacgac ctccatctct ttgtatcatt 642360 aatactacag ttcagttaca tgagaagaat ctcgccccca ctttgaatta tgaaagtaaa 642420 ggcgctggtt ctggcttcca caggctgggt gtattcctta ttctttcaga agaggtgctt 642480 ttctatctgc aaaaccattg gtgttatttt gtatctccat agcctctcta agtcagttgt 642540 cccttccaca aacctataaa ataggccaag gttatagaga ccatctgaga actttaaggt 642600 tttcctttat gagaacgttc ttaaataagt aagaaatata tagttgtata tttattttct 642660 aataaacata ataaaaatgc atcatcttgg ctttcacaca aaatttggga gaaaggtttc 642720 aagataatta aaagtcttta ggagccattg ccctctagtc ttccagcaga cacccaggca 642780 ggtatgaaca taaacacaca tccacatcca cgcaaacaca tgcacacagg cacacacaaa 642840 agaatgaatg tacatgcata gaattgcaca cgtgctcaca caggcacatt catgggtaca 642900 tgtgtgtgca cacacgcaca caaatatggg ccctacaatt aatctgtagc agcaatctct 642960 ttgaaaacac cactgggaac cctattcttg gaaagtaagc agaccatcac cccattctct 643020 tcaaaacaag ttaacaaaag ttagcactta aaacacccct gttttccttt tatcttttac 643080 ctatgttgtt aatattctac gtgatatgat ggacacaacc gttatattat ttatcaaatt 643140 cattaatatt tcatttaaaa cctacataag tgaaatttac ttttaaacat attttattta 643200 ttgctcaacc tttataaaaa ccacattaaa tatttaaaat ttttaaatct gtatgatccc 643260 attatcttaa cacttttttt cttacaatcc ttgcctatac atatatatga aaagctcttt 643320 agccgtacag gaatgtacaa tgtaattaga aaaccaagtc atgaacacaa atattaacta 643380 gaaaaaaaac taaccttata agcactttat aatctacaaa ggtctttgca tgtatttaat 643440 tgtgttgctt ctctctattg aggtgggcat cacccttgca cccatttgat agatgattca 643500 gaacataaat acccacctaa ttttatagct tatcaattgg cagagccaaa aaacctcaaa 643560 gttagctctg ctgattccaa agcctgagct gcttctgcaa tatgcacgca gggtactaga 643620 aaacaaggct ctgggtgacg ggtaggggag ggatgccaca aagaacagat gtaaagcagc 643680 ccccaggtgg gggatgattc agacaggttg tgggacccca gagtgtgcat ttctagcatg 643740 ttcccaggtg atgctggttc agggctgtat aataactctg tgtataaaag gaaagaaaca 643800 acaggtacta tacatgtatg gtagatatct gcaaacataa ggtggaagga aagaagccag 643860 acacaaatga atgcagaaag gttgatggta ttttacatac agttcaaaag cagccaagga 643920 tgtaccaagt tgttcatgca tccataccca ggtgggaaac agatgggctg catggtttaa 643980 aattctggct ccgctcctct ctacctgtgt gatcttgaac aagccattta gcctctctgt 644040 gcctcaattt ttatactcat atttacaaaa cctccttcct aggattgctg taggtattaa 644100 aagctaatac atttctcagc agagaactta atgcatatta gctataatta tcatcctcat 644160 tattacacca gatgttttta aaagggcatt tatgtccttg atactagcat agtcaaatga 644220 aaaaggaatg aaataaatga tacaatccag ataaccaaat aaaaaaacca tatgggcatc 644280 acatgcaagc caatggaatc atgccactaa tgcttgaatg aagaggcaca gtggaaaatg 644340 aatattaaca cagatgaaga tcacatggtc agagtggttt caaggaaaag gtgaaacttt 644400 aggaatcaga aatatggtgg agattataac gttgaaggaa ggatcaaaat actgggcgtt 644460 ggcccatttt ggacaagaat cttcaggtag aggagatccc tgggacaccc taaagagcta 644520 ttagcttgta atctctacag caaccctagg agggggtgct gtaattatag gtacagaaat 644580 tgaggcacag agaggccgaa ggacttgttc aaggagataa ccagcccagc ttccagaaga 644640 cacagcacac tgaacggctg ggagccacag gcagtgtgct gtgcagtggg tgatggagac 644700 aagacatggt agaattcacc accccattga gtgctaatgg ggatgatgat ttatcttctc 644760 tgtttctcca tgaaaaacag ctgtacataa agcagctgct caaaagttag aacatggctt 644820 cagacatgac aactctgtgt ctgtccccaa gccacatgga aactgcttgc cttctgggaa 644880 atgcatctga atataagagt gaagggtggc gggggtggaa tccacccccc agctcccaca 644940 cagggttgtt ggcaggctat tggcccaaga cttgtccttc tcatggtcct ctccataggc 645000 cacatgggta tcctggtgat atcatggcag gcttccctgg agcaagtgat cagacagaaa 645060 gagagagaac tggggcaccc aagtagaagg tagaagctac agtcctttta taatctggtc 645120 tcagagtgat aaaatgtgga gagtttgaat tccaggagat gagattacca caggtcacct 645180 taaaaactgg ctaacccatg gctcataata tatttttgct gcaattaata tcctggacag 645240 cacttaccca atttttcagg atgacatgat ctattttctt ccttgtttct ttattttttt 645300 actatcattg atggcaggaa atcaaaatct atttactatt ttcctttttc tacataatta 645360 ttaagaagtt ttctgctgag tacaatggct catgcttata atcccagcaa tttgggaggc 645420 cgaagcaggc ggatcacctg agattgggag tttgaaacca acctgaccaa catggagaaa 645480 ccccgtctct actaaaaata caaaatcagc caggcatggt ggagcatgcc tgtaatccca 645540 gctacttggg aagctgaggc aggagaattg cttgaaccag ggaggcagag gttgcagcga 645600 gctgagatca tgccactgca ctccagcttg gtcaacaaga gtgaaactcc gtctaataaa 645660 taaataaata agaagctttc ttattgggca aaatatagta cctatgtaca gaaccagaca 645720 gatggaaaaa aaaaaagaaa gaaatggcca gcctgcctcc atgcgagtta gaggaaaata 645780 ctgtttttga tatcttttgg ttaatattca tacttgtctt aaaaaataaa tcaactttct 645840 tccaataatg tgacttgaaa taacttcaga gtgaatgtaa tatgaaccct aaatgttctt 645900 cgtctttccc ctgacacatt caatcatgtc ataagggcct ggaaaagctg ccaggaagtg 645960 gagatgttgt cattcttgtt caagcttagc atcaaatatg acccactcca gcttggaaac 646020 atgaatttga ttaacggtta taatctaagt aacttcatta tgtaagcata ataacccagc 646080 tgaggagata ttttagtatg tgctaagaat ttgttaattc ctggctggaa aaatcatttt 646140 ctttataagg attagagctg cccagtaggc agcctcactt gccgaaatct tatgaacaat 646200 aagtatttgg acaggagaaa tttttgattc tgcagcaggg ataatcacac ttggtgtttc 646260 tgtggggcca ttcttccaac accctcagag ggttcctcta acataatctc attaatcctc 646320 attacagcct taggaggcgg caggtctcat tgttcttaca gatgaggaaa cggagatgaa 646380 actgagaggc agagaccaca aacagggaaa atactgcttg gcctttgaat ggcttgagaa 646440 gaaacaggca aaaagactca agccattttc tctagcaaag ttctacagac tctaaaaaat 646500 aatgttttgt acaccagtgt tcacaatagc caaaaggtga aagcaacaca agtgtccgtt 646560 gacagatgac tggattaaaa aaatgctgtg tacacatatc ttgaaatata attcaggctt 646620 agaaaagaag gaaattcaga cacaggctac agcttgactg aaccttgagg agattatgct 646680 aagtaaaatg agccagatac aaaaagacaa atactgtatg attcttctta taggaggtcc 646740 ccagagaagt caaattcata gagacggaaa gtagaatggt gactgccagg gcctgggggc 646800 caggaaaagg agagaatagg gattgtttaa gagttgccaa gtttcaggtt gggaagaaga 646860 aaaagtttgg gggatgaatt gtagtgaagg ctgtacagca atgtgccttg cagctgagaa 646920 aatggaaatt tcaaggactt tatggggagt ctcctgtaaa tggactcagg ccccagaatg 646980 aggggcttcc aagggtgttc tgatttgaag acagactaag aatgtacttt gtccactgaa 647040 agtgaccaaa atgaccaatt ttttgttatg tgtattttac caaaaaaaaa aaaaaaagaa 647100 tcctgaggac agcaagtatt cgctgtgact gggaagatac tactgtgggt gttttttgtt 647160 ttttgttttt ttaattttac tttaagttcc agaatacatg tgcagaatgt gcaggtttgt 647220 tacataggta tatatgtgcc atggtggttt gctgcaccca tcaacctgtc atctaggttt 647280 taagccctgc atgcattaga tatttgtcct aatgctctcc ctccccttgc cccacccacc 647340 gacaggcccc ggtgcgtgtt gttcccctcc ctgtgtccac gtattctcat tgatcaactc 647400 ccacttataa gtgagaatag tcagaatggc tattattaaa aagtcaggaa caacatatgc 647460 tggcgaggct gtggagaaat aggaatgctt ttacactgtg ggtgggagtg taaattagtt 647520 caaccattgt ggaaaacagt gtggtgattc ctcaaggatc taaaaccaga aataccattt 647580 gacccagcaa tcccattact ggttatatac ccaaaggatt ataactcatt ctacaataaa 647640 gacacatgca cacttatgtt tattgctgca gtatttacaa tagcaaagac ttggaaacaa 647700 cccaaatgcc cattaatgat agactggata aagaaaatgt ggcatgtata catgatggaa 647760 tactatgcag ccataaaaaa gaatgagatc ttatcctttc caggggatga agctggaagt 647820 catcattctc agcatactgt gggtgttttt atggctccca ggtgatgtaa ggaataggga 647880 ccacaggttt aatgaaagat aatcgtgatg tattgagtgg cttgggaaga tgttgattgc 647940 aagtggatta gtcacttccc tcattaaggc ttgcctctgt acccattgcc ttcatgatgg 648000 gcagagtggg ctccctactt cagattccag attgtggtta ctcatatcta agtcttatcc 648060 aagagactgc cctctcctca gctcttctta ttcccctcct gctcaaggta cctgggctgt 648120 ttctttctac tggaagcagt agaggctgcc taggaagtgg agtactgtcc tgacattcag 648180 ggacagcatc atcggtacaa gaccagtcca gtcccacaag ccaaagatta tctgcagccg 648240 ccatcttgaa ttcttaacaa ttttgtcttt gaaattgtgt tttgcaagtg aagtccagtg 648300 tgacaatgga gcatgaacag ggtatgtgga gccacagctc ccatgtcatc ccacctccca 648360 ctgcctctcc agaataggtt ttcagctgtt cactttcctg ccccctggag ccccaggctc 648420 ccctttcctg caactgccca gcaatggcta tggtcatcca gtccatgggg atctgggtaa 648480 gtatgtggag aaggtcagag acagcctcct gtaacatttc tgggtgtggc acccctccct 648540 gcttctaggt ggcagtacca gagagtttac agaggatgac cgggcagggt gggtctccag 648600 gtcactgaag gtcacctatt cgactgagag aggcctgact acacgtcccc accctggcct 648660 gggtatgatg atggtgggga tccaggcatg tggtggggca catgagtgtg catgccaagt 648720 cacagggctg ttactgggag ttagggaggg tcagcacttg accagccagt atcaccatgc 648780 cagaggaagt gggatattaa ataaaaaata aaggccatca tgacagaggg agagagggag 648840 accacagaag gaaggaaaaa gctttatatt ttagaacttt aatggcacct ttttcctgct 648900 ttttgaacaa aagcctccat attttcattt tgctctgggt cctgcaaatt gtgtagccag 648960 tctcgtctgc ttaattctac aaatatgcaa taggcttgcg ggagatgttt gggtcttgcc 649020 ttgcagctga gaaagtggaa atttcaagga ctttatgagg agtctcctgt aaatggactc 649080 aggccccaga ctgaggggct tccaagggtg ttcaggcttg aagacagtca ggctgtcaga 649140 tacccctgtg gtcagacact ctgcaccctt ggcctcctcc gctactataa gggaaagagg 649200 ctttgcactt ggaatcagaa gacctggatt ctccttctag atcttccatt tactagttgt 649260 atgactttag gctaattact tagtttcccc atcctaggta attataggta aatggaatta 649320 agaatccctt ctccactgag aaacacatgt gttgctgcaa gctcatgata tgaaaatgat 649380 ctgagacgtg aaaggacaga aggacagatg cgttattaac taactgtgct gctactacca 649440 tttagctttc cagaccctgg aggaaggaag gaggaaagag aagggaagag aggggatggg 649500 aaagattcat cactttaggg attaatgaag atcattttac tgtattactt ttatggtaat 649560 attgattttt taataaactt actaaataaa atagaacttt gcattaggga taggagagag 649620 gcaaggggaa taggtctagt catttccagt cttaaacccc ctagttctct gtttccttac 649680 ttagaaatta aggagaggct gggcgcggtg gctcacgcct gtaatcccag cactttggga 649740 ggccgaggtg ggtggatcgc aaggtcagga gatcgagacc atcctggcta acaaggtgaa 649800 accctctctc tactaaaaat acaaaaaatt agctgggcgt ggttgtgggc gcctgtagtc 649860 ccagctactc gggaggctga ggcaggagaa tggtgtgaac ccgggaggcg gagcttgcag 649920 tgagccaaga ttgcgacact gcactccagc ctgggccaca gagcaagact ccgtctcaaa 649980 aaagaaaaaa agaaagaaag aaagaaatta aggagaaagg ggagaagatg tcaagtagaa 650040 attaattcca aaattctctt atattctaat ctttattttt gcccatttaa aggcggtgtt 650100 tggtgtctgg tttctatttg accatctgca tagacctttg ttaatataga tgcaaatcca 650160 attaatctgc tggaaatgtt ttgtctatgt gtctcacttc tatttatagc ataatttaga 650220 atcaacttaa aatagtactc atgtgtcttg ggtcatttcc atggctagtg tttttattcc 650280 atcatgtcgt atggctgaaa tacttatgca gtatatggaa aagttcttag cacacagtca 650340 acactcataa aaattagcta ttgttgttat tatggcactg tgaaggagaa aacagaaaaa 650400 agcaggagac agaaatagag ggaggatgaa acagaagaaa gagaggggaa agtgaagaag 650460 gaaggaaggg aaaaatgaag aaaaaattgg gagggaggaa cagaaggata gagggaaaga 650520 aataaagaaa aaaggagaag gaggggaaat ggcaattagt gggggaaaag accttgggga 650580 tcatcggatt gagttgtttc aatccaggct gtatatttta ggatcgtctg ggaaacttaa 650640 ataaatccat gcataacccc cacccccagg gactctgagc caacgtgcgg tggggcctga 650700 gcactggcct attttaaagg cttctaggtg attccgagat acaggccagg ttgagagccc 650760 gtgatcccat tcagctcctc tatgactcag gtgagaaagc caaaacccag gacggccaag 650820 ggtcctgccc agtcccagcg gcaggaggtt ggagtcagat tctctgctcc caggcccctt 650880 cctcaccttt ccttttggta agacatatgt gaggggcacc actctacccc aggcaccacc 650940 taaccccaca tcacctctgc aggccagggt gcggcagttc ctttacctgg gacaccagga 651000 ggccagtggg tctgcaccct gagctgcaga atccaggcag gtggctgcca tcttacagct 651060 cgacctttga gacccacgct gatgtatgtg tttacccaag gtagttttaa aatagaataa 651120 taaaaaaaat gtattcagta aatcttgata acaaagaaaa cacattttga ttcaacactg 651180 tgcattaaag tgtgaactgt ggaatccagg cagtagatac atggctgatt ggcttcctgt 651240 atgtttgaaa ttttttcata ataaaaattt gggaggactg gtttaaaagg gacttgaaaa 651300 aatagcttta aaatgtgttt atgtcccaga gcatctcctt cttttgacct cccacccggg 651360 aaccctgtaa ttcctgcctc agtttcccat cttgggcatt gggccaggtt tatgctgcct 651420 cgttcttggc tccacaccct cctctgccat atctgctctg aatgcctgga gggactgaga 651480 aacttcccag gatacagact tcctgtgtta aaacactgga agtcctggac accctgggac 651540 agttggccat ctcctatgtt tggggtgatc atgacgatga tggttttcaa ataggaccga 651600 tcagagtcag atcctgatgg actcctgtat ttgggcattt gacacccttt cttctctata 651660 aaatgaaagt attgagccag atgcttgtga caggaatctt gtctcattcg ggattatcca 651720 ggctgtttgg tactttctcc tgttttcttt tcagttgttt tcttttcaat ctgttttctt 651780 ttcagcagaa ccaggtagga acaaaaacca taaaaatgta taaggattaa ttttgcatta 651840 ttgatagagt cattaaaaga cttgagagta aagtttggaa ccagtcttta atatcagtga 651900 tttattgata gaatttttca ttctctctgt atcctagggt taaaaaatta agatattcat 651960 caatttatca ctgaattact tgtcaaaacg tacagtgaca aactgttcat attttaatta 652020 tttaattaat aaataagggt ttactttcat tgataaagtt aattattgct cttagcttaa 652080 tcttactatc ttctcagtat ctcttgtacg atgggaacac cctttaaaat tattaatata 652140 gtgaaacact ctcctaagta ttattctggt aaatgtttaa caattagcta ttgaggggga 652200 gaggatggag aaagccgtga tttctagcac tcgccaattt cagtggtata aatactacca 652260 ccattgccaa tttcaagcta aatgggaaag agacatgact gcactgccaa gctgggcaga 652320 gatgtgcaca atcagatctc cctggccaat gacagcagct ccactacacc actgcatctt 652380 tatgctgcaa aaaagtaggt cagagggatg ctcccttata tcataagaac acagatttac 652440 tgagcattaa ggatgctgtt agataatatt atagtttatg aagcaaattt ataaattgat 652500 atgatgtaaa acagcacctt cctcaatggg taattttgca agagaggcac gcagcacaca 652560 acctttggac aaagccttct tgggtctgga tctcccttgg ccctgctagc agggtttgcc 652620 cacagcctct ccttggtacc aatccctgtt aaattacccc atccatttgt tatgcttcag 652680 aaatcctcgc aaaaagggct gctgtacaga catgttgtca tctctaggca tccataactg 652740 tgacaagtga aaaggtcatg ccttcaaaca ttagcattgc aaagaagcca tggtaatgat 652800 tcattttttc ctttccacca ttactttaaa gggctgaaaa tacttgagct ggataggaga 652860 acatgggcta gtcagagcat ttctctctaa gtgctgaatt taataaccag aacaaaaata 652920 cccattttag tagggcactc tttcaaagta gaaatctaaa taaaactgag gagtattgtg 652980 tgcagattaa gatgggcaag tcataaacaa accagaggtc tatggtttgg ccaaggtact 653040 tctctcatca aatgcgataa aacttgtgat tattttttta aaaaaggaaa agagaagaaa 653100 acaaacaagt cctcaaaaca atgctgcagt ttttggagaa cagttcttcc agttggtggt 653160 tttaaagtac tagggaatta cattctgggt caacaccagc cttggagctc ctagaatagg 653220 acagaaaccc ttacttcaga attggcttgc tctcattgga atatagtcag tgagtgttaa 653280 actaccctgg atttgggagg tgatgatggt gacttaccaa gttctcaaag gaaaactgtc 653340 tgtttttatg tcttaccatt ttatacattt cctttttaca aacactgcaa aataggaaat 653400 cctgaccata gccttgagat gcccaggaga ctgggaggca ttaaacatgg attgattttc 653460 agttttgcaa caagagtttc tatattttat tctaaggatg agggtgttgc aggaatcagg 653520 acactcatca ggaattgggg cgtgggggtt gatggtagtg gacaggggtc acctttcaaa 653580 gctaaattat atgtgggtgt catggtttct gattcacatt ccccagtcgt gagagaaaga 653640 atgaggagta aatattttct tgttcatagg cctgtaattt atttattcac agttttgtaa 653700 tttaggttac ttttgttggc tttgagatct ctaattatct tgagttagcc tctttcccgt 653760 atgagaaaaa atcttgatta gtggattgag gccaaacaga aagtgccacc accttcagtt 653820 cctctgtgat ggcagatcca tggtgagcct ggggtttcta cagccagtaa gcctccagct 653880 gtcgaggaac atgccagctc acctttttat aggtgcaccc aatctctact ctttgagttc 653940 ccctgttgaa ttcaaatggt tgaacttaaa ttgttgaact caaatggttg aaagggaatg 654000 ttcttgttcc ctcaccataa atgctgaatc ttaacacctc ctcttattcc ctcttctctc 654060 tccaatctcc ggccacaaga gtgcaaaatg gtgctgccac ttggtcaaac agtgtggcag 654120 tttctcaaaa tgttaaacat gaaattgcca tataacccag tagttccact tctaggaatc 654180 tctcctggaa aaaaatgaaa acatttgttc acacaacagc ttatacagga atatttatag 654240 tataattact cataatagcc ccaaagtaga aacaacccca gtgtgcatca gtgggtgagt 654300 ggatttaaaa aaatgcagta tatccgtgtg ctgcaatatc atttagcaat aaaaaggaac 654360 aaagtactgt gctatgacat ggatgaacct tgacaacatt atgcttagtg aaaaaaatcc 654420 agaaagctag atactaaaga atacatgcta tatgattcca tttataaaaa atgatctaaa 654480 aaggtaatac gggtattgtg ttagtctgtt cttttaaaga cataccagag actgggtaat 654540 ttataaagga aggaggctta actgagtcac agtcctatgc gactagggaa gcctcaggaa 654600 acttacaatc atggtgaaag gggaagcaaa catatgcttc ttcacatggc ggcaggaagg 654660 ggaagtgcag agtaaagggc ggaaagcccc tcataaaacc attagctctt gtgagacctc 654720 actcactatc acgagaccag catggaggta accaccccta tgattcaatt atctcccacc 654780 aggcctctcc catgacacta tgggagacga attgtattta tggaaactac aattcaagat 654840 gagagttggg tggggacaca gccaaaccat atcagggaga gaaggtagat tagtgattgc 654900 ttagaacttg agggggaaaa gagaaatgac tgcaaatggg caggagaaat cttttggggt 654960 aatgtaaatg ctttaagatt tgattcagtg atgattatac aactgtgtat atttgtatac 655020 aggttataat ggtatatatg tatatgtact ggataatata aatatatttg taatgggttg 655080 aatagtatcc ccaaaaatta atgtcccctt agaaccttgg aatatgacct tatatggaaa 655140 tagagtcttt gcaaatataa ttcgttaaga agagatcata ctgcattagg gtaggtccta 655200 aatccagtga ctggtatcct cataagaagt ccatgtgaaa agacacagaa acattcaaag 655260 aagaatgtaa attatgtgaa gataaggcag aagctgaagt tttgccgcca caagccaagg 655320 aatgcctggg gccaccagaa gctggaagag gcaaggaagg gtcttcctct agagctctta 655380 gagggagcat ggctctgttg tcgacttgat tttggaattc cagcctccag aactgtgaga 655440 gaagaaattt ctgttattat aagccacata gattctagta atttgttaca ggcactctag 655500 gaagcgaatg caatattaag tgtacaactg aattgcacac ttaaaacagg tgaattttat 655560 ggtatggata ttataccaca ataaagctat taataaaaat aaacattttt atttatttta 655620 taggctaggg gaaggggggg atcagaacca aaggctgggg acagtacagc cagttttgct 655680 gcatctcaga aatgccagaa aaggaatttc acaacagttg tgagcaactg tccttgatat 655740 gcaggactct tggcacctct ttcttgagtc accaatttgc ctactttcca tcttattaca 655800 cggtcagtgc tgtggggcac atctctgcca catggctgct gactctagag aaactcccaa 655860 atgtaggttc ttctgtgggt gttcaggcta cggaactggt agtattttga cgtttcatta 655920 tatgtctcaa acctctctag taagccatgg gaaaagacat gacccagtat gtgccagtct 655980 tagaagaagc cacagtgttt ctatggtcaa gtaccttgga agtcttacga ggcaagcaat 656040 caagtacgta gtctgagctt gacctcagaa atgggggaag ggagcttctt cctgtgattg 656100 gggaaatgag ataaaaagca aataaaaagg ttgttatgtt ttgatgaatt ttcaaacctt 656160 tctagtcctt tttgttaaca tcttgttcct ttatcatatt tttaaaatat ctttaaacat 656220 tcttgcatag ttattttgca gtctgtatct gacaactgta tcatctgaag tcctgggagg 656280 ctggttctca atcatggtgt tagttttctc atgtgttctt tagtttcagt ttgtgagctc 656340 acggccagca gggctttatc tgggtgcatt tcagtgggcc tggacagagg acacattctt 656400 ctagagtatg ttagcttttg ctaggctcct caggccatta tcaaattacg gtcaccttca 656460 tgttaaagct ttagcatgaa tttgactaca gacctatgta gagtcaggcc agttttataa 656520 attctcaggg gagagattgt ttttctacat atataacaca agctgaggca gctttcttct 656580 ctctttgcct ttgtggattt ttatttattg ttattattat tttggttata tactttctgt 656640 caagatagaa ccctttgagg agcctggctt tggaggtctc atatttaatg tcatgcctct 656700 caggtagtca aagcaccgcc attatatatt acctctggct tttcactatc agcttttgtg 656760 tttggtctct ggtttttctc tcactttctg ataagcttag tatgcatttt aaaaggtgtt 656820 tgtcatatgc agtctacaat ttataagtgg cttgtggaat tggggtggga tcttttgtca 656880 tctattgcca agaaaagaag tctatgtatt agacttcttt taattttgat gtgggaaaag 656940 gaaacttgag aagcttcaca aataaagggt tcccttttct cagtaaattg gagacgagat 657000 tctctgctat aagttatgga agaaggacag gtttgaggtc tccagtgact gataaaggtt 657060 tgcaaggttt ataacaactg tgggagatgg gcattgtgaa aagtggttac aaggactggt 657120 tagcagcaac aagggattca cctaaagttg actaaaagtg gaagttttat ccccattgtt 657180 tataatgata gttagaaacc agtaacatca ttgtattagt ccgttttcat gctgctgata 657240 cagacatgcc tgagactggg ctgtttacaa aagaaagagg tttaatggac ttacagttcc 657300 atgtggctgg ggaggcctca tgaccatgat ggaaggcgag gaggagcaag tcacatccta 657360 catggttggc agcaggcaaa gagagagcac ttgtgcagag aaaatcccat ttttaaaacc 657420 atcagatctc ataagactta ctcactatca tgagaacagc atgggaaaga tccgcctcca 657480 tgactcaatt accccccacc aggttcctcc catgaaacat gggaatgaat tatgggcata 657540 caattccaga tgagatttgg gtggggacac agccaaccca tatcaatcat tctgggtgtg 657600 ctaagggaca taggccatag ccctcaacag ggttggaaga gcaacgtgcc gtggatatga 657660 aacggcatgg caatttctgc tgagggctca cttactcaag tttcattttt ctggtgcctt 657720 tcctttattt tgctcgagat tctcatgcag cagtttcttg aataaatttc attttgaaga 657780 aatatctctt gaagcatggt ttacctgagt gttttgccag ggaaaatcaa gaaccctgct 657840 ttgctgaaca agttgtgtcc cttttgcttt ttcagttcct gcgatgataa catcctatcc 657900 aaatactacc ctggccacgc aggggcagaa aaaggagatg agctgcacgg cgcatggtga 657960 gaagcccatt atagtccgct gggagaagga ggaccgaatc attaaccctg agatggcccg 658020 ttatcttgtg tccaccaagg aggtgggaga agaggtgatt tctactctgc aggtaaaagc 658080 atggcaaata caacacaatg gaatgaactt tattggaaga ataagtcttt cctttcacag 658140 aagcgggtgc agataagtag cagataatct ttcggaattt atttacgaag cactatttct 658200 ctcccctttc acacagcgag attagtgaag tagccttcaa aaatagtgct tcagcctaag 658260 tgttattaag aatagggtta ttatgaacgc agcagggaac ccaaatgtag taaaaaaaaa 658320 aaaaaaaagt gagaaataag gtttttaaat gacagttaat ccttcaggaa tgatggccta 658380 tgctgtgtgc atgttttaac ttcctgcaaa aagaaaaatg agatgggctt tgggacaaaa 658440 atattatcat aaaaactatc ttgcttcttt ggaaaaatcc acaataaaaa aaaaatctgt 658500 cgttaaaaga ggatcacaaa agctagagaa aaggactgtg agcagtgaac tggtttgtgc 658560 tgttgtcatg cggttggagg atgatactgt agcacacaca gggtggggag gtggggaagc 658620 cctgtgtttg aaatgcttat attggctctc agacaagggt ccattcctgg aatcctccta 658680 gaaaaggaat ctgatgcgag tcttgcgggc ccccagccct gcctgcagta tttaatctgt 658740 ctctttaggc atggttgctt tggataccat gaaaaaaaaa atgtatatgt gggatatatg 658800 tcaagctgac cacgacatct tatataaatt acacatccaa tttaatgagc tacacctgac 658860 atggataatg tacgtgaatc ctatccatcc gcctactttc aattacactg aaataatttg 658920 tcctcagagg gatacgtgca tgtgtgtgat ttagtatgtg agtctggagg aatgggggtt 658980 ttgtgagtgt gtgtgtgtgt gtgtgagtgt acctatgtgt gtgcttggca tggcaggaga 659040 actgaaagag tggagagaga gagctttacg gctcaaagtc attttgccta ctgaaaaaga 659100 tgaatttctt tctgctttac acatagattt tgccaactgt gagagaagat tctggtttct 659160 tttcctgcca tgctattaat tcttatgggg aggaccgtgg aataattcag ctcacagtgc 659220 aaggtaggaa gacgatagcg taagagaata aacacagtca tttcaggatg ggagctgtat 659280 gctcagcctc aggcatctct gtgtcctcaa cttgccatgt aacacttcct aattcccagg 659340 aaattttgaa tatgtataat gtcagtgcta aagcagaatt ttgcagtgcc tgggattatg 659400 tcaaagtaaa gcccccaaac agggaacgaa gcccttagag gaaccagtca agatgacaag 659460 cccatgacag tcaagccaca tgcacacaag tacagcggtg gaatttcttt gctcaatttt 659520 aggaatccat gtactagatg accagaatga aagggaagtt taacatttgg ggccaaaata 659580 tgttttgagt tagagatcca aactagaatc gtgacatttt atatcctcca ggcttggtcc 659640 agttcttaag ggctatgaaa attggaagtc ttgggaaagt ggaatttctc ttccctaaaa 659700 tgtgattagg aaaaagaaaa tgcttccaaa taaaaagctt ctgttcttgt ctaatgcaga 659760 caaatcgttt gtgagtcacg ctcagcattt ccactagcgt tttatgtcag agctctgttt 659820 gaactaactc gtagtctttc tgttgatggc acagagcccc cagaccctcc cgaaattgag 659880 atcaaagatg tcaaagcacg cacaattacg ctcaggtgga ccatggggtt tgatggaaac 659940 agtcccatca caggctacga tattgaatgc aaaaataaat caggtaagtt ctttacttcc 660000 tccagcttcc cttccacctc agaaagttct tttatttttc tccttattaa tgtgttttac 660060 ctgtaagcgc acagctcagc tcacaggagc tcagagggca ccacttcccc cagtctcctt 660120 gctggaagca catcctggct ttctgctgtg ggagtggagt ttcgtgttga ggctcagctc 660180 tgcttctttc ttttttagcc agcccagact tcagtcttgc ttcctgctgg actccttgat 660240 attgcagctt cctgttggca tgtgggcagt ggctgatgga gacaggcccc caccatgacc 660300 ttttctattt cacctgctcc cttcacttcc cgtttcccga gctgggtgac ttttgtagag 660360 cctgagccca tgtcctgcac ccagagcgtt gagctcaagc tgtgcttggt gttggtcgga 660420 taaactgtgc agtggtggtt ggtgcagaaa aaggaaaatt cactctggag caacctcctg 660480 gaaatgctca gggaccatcg gcgacactgg ctgctgcacc caggaccact cggcccagag 660540 cccataaata aaactgaccc tgctgccagg gccgctgcag gtgtgcccat tcattgcctt 660600 caaggaacaa tgcccgggcc attttgaact ttatgatgca ttgggcgagg gtagaatacc 660660 accacagtgg cctctagtca gaatttttac tgtgtctcat aaaagatatg aggaattcga 660720 gcaccaccag catgggaagg gttaataaaa tccttctagg ccgcaaaagc agctttattt 660780 ttcacttcct ggataccgca cgttatttca gattacccag ttgtgaccca tctaatatct 660840 ttggcactaa agctgtagta aaaaatcaag ctcaaggcag ctgggaacca caggtcagga 660900 gtgaggaaat gtttcagcaa gagcaagcca ggaacagagc caggaaatgg tgactgcaaa 660960 ggcaagccga ggggtgactc ttcgggaatt caggagaaca gaatttgaag attgagaaga 661020 tatggatcaa aacaaaaaat agtgttttga aaagtagtat ctgtgactgc tgggttggaa 661080 atgcacatga ggaaagatgg aatggctcag gtcatcggcc tctgagttgc aactgggggc 661140 ctagaagtga ggtgtcactt acacaaagtc tgaggaaggg ccttccgggg ttgattggac 661200 tgcaagtctc accgtagcca agaaatgctg cagagccagg gccctgggct caggggtgag 661260 gcacagtgac ctggggggct cacccaagac agtgctgagc tgaacaagca tcttttgggg 661320 actaggacca acaggtttcc caagggccca gggaggagag gctgaccttg cctttcttac 661380 aagttcatgt atacaggtct tgaagtgaag caaatgcttc ttaggtgagg caggcacatt 661440 tgagcagaaa ctgtcctgga acttagtgac agtgatgaga gctcagacag atgcagtgag 661500 caccgtgggg acagggacag ccctttatct cactggctgc gcactggcta tggggctgca 661560 ggctgcccat gctgttggtg cgggagcaca caggagacct ctcctactgg agcagcccag 661620 gacctcccct gtcctcatgg aggagcgggc attgccggat gctggtggca ggcctgggct 661680 cagtgatttg ggacccagcc tgtgtgggat tcgctgctgg gcctgcgttg caccagctct 661740 gcaccctcgc ttgcgcatct cacctgtgaa gtgggcactg ctgcatccac ctcaaaggac 661800 tggcaaggag accacaaagg ccaccagctg ccctctgcct ggagtcctcc cttccctgag 661860 ccacccagtt actaccccct ccatagatct caattctcag gtgctcaccc agctccttct 661920 ccctttcaat ctgggcaggt ggcattatgg gtcactatat atgtatctct atgattactg 661980 acaaatatgc tgattaatgc atttcacctc caccacgcta gaggctcctt gggggctccc 662040 tgcacctagt aggtctattt tcacccagct catttctcca acacccagca ccgcacccaa 662100 catgtggaga cactcaatgg aaattggtga actctaagaa gggaagacat tgaaaacgcc 662160 ttcctcgttg tctggagcat actcaacatc taataggtgg tagcttgtag attgctccag 662220 catgcaggaa aatacttagg agtaaaatgc ctctaaaacc ctctgtgtta aactacttac 662280 tcagcatcta agtgtcctca ctatctccct actcttaccc aggagtttcc caaaggcagg 662340 gactctggtt ctctgtgtcc tgggatcccc agcacccagc acaatgtcaa gtgaagagca 662400 tactgtaaat gtttattgca ttaatttaca tgcaattgaa atctaagaat cattattatc 662460 aacagcatct ttaaatgtat aaattgatca tggtttatat aaccaaagca ggaaagctcc 662520 ttgtctataa agctgagtac aggcgggatt gagggatact cttttccatc cttcatgccc 662580 tacttcaacc agagacaggg ccagtggtgt ggctaagatg tttatgtagc cctggagcaa 662640 gtcattttaa ggggcagcat gggtcccagg agaaaagccc acaggacaag cagatccaag 662700 tccatgacca aggtctctac caggacccta cagaacttca attactttca gtttggaagc 662760 cctgggagga aggagctgtg ctgagagtag atagcacctg tactcactgc tgtacgagtt 662820 gtgttagtca gatttttcat gtattagttt cttcctccag aaatttttgg tgtataaaaa 662880 ttacaaccat aatttaagtg agtgtagttt tagactgagt acatagaaaa ctgatccttc 662940 aagtattaat aacagcctaa atgtcacttc ttccaggaag ccttccctga ctacctattc 663000 cccttcacta ttcatagcat gtcttggaac acttggtggg cttgtgacta ttaatttact 663060 atctgcaccc cactgaacag ttgtccccct atgggccata gtgagccctg agggctggaa 663120 ttgtctctga caaaccttat gctatgtccc tgtgcccctc atagtgcctg acatgtatac 663180 gagactcata ataaccatta gtcaaattgt tgactctcaa catctgtttt aggcaacggt 663240 gaaattatcc ccccaaaagt tttcctttcc ttttcattaa ttttcaaaga aagcagcata 663300 taaccaatgt attaaagtac ttcacattcg taacagaaag aacttctgca agtgaccatt 663360 cactctatgc ttgaacaatc cgagaaacag aaactcacta acccagggag cacagctctg 663420 cctttggcca gctgtgactg ctacaagttc ttacatttat tgcaccaaaa tagaccttcc 663480 tggatccagt gtctctcctc ccacctctta accctttggc caaatgacag tcctcccagg 663540 atttgacaac agatgacttt ccttggttta ctcttttcca ggaaacactg aacaccccaa 663600 gtccttgtta ttgtatctcc tgtcatcatc tcctgccccc ctaactctgg tcatgcccag 663660 tggcagcacc agaggcgtca tctgagcggg cacaggcaca gtgaagctgt cccttcctta 663720 tctggaacat tcttcttctc ccataggtgg caattacaca ggttgccttg gttgccatat 663780 tttctgattc ccagggacta ctgcttctcc cctacaagga cccaaggcca cctttaacat 663840 cccttcgagc atattgtctg gggacctcca gcagattcgt ctgcagtttg ttgcctccct 663900 ttattccctt ccttggaagg cagcctgccc ttcagagtct gttcctgtgg gggccatctc 663960 ctgtccgcag gttctcttgt tgcctctcct gtccacggtt tctctggtaa ccccccccgt 664020 ccacggtttc tctggtagcc ccctcctgtc cacggtttct ctggtagccc cctcctgtcc 664080 acggtttctc tggtggcccg ttctgtccac ggtttctctg gtaacccccc ccgtccacgg 664140 tttctctggt aaccccctcc tgtccacggt ttctctggtg gcccgttctg tccacggttt 664200 ctctggtaac cccccccgtc cacggtttct ctggtagccc cctcctgtcc acggtttctc 664260 tggtggcccg ttctgtccac ggtttctctg gtaacccccc ccgtccacgg tttctctggt 664320 acccccctcc tgtccacggt ttctctggta cccccccccg tccacggttt ctctggtagc 664380 ccccccgtcc acggtttctc tggtaacccc cccccgtcca cggtttctct ggtaaccccc 664440 ccctgtccac ggtttctctg gtaaccccct cctgtccacg gtttctctgg tggcccgttc 664500 tgtccacggt ttctctgctg gcccctcctg tccacagttt ctctggtacc tccctcctgt 664560 ccacggtttc tctgttggcc tctgctgtcc acagtttctc cggtgcctcc gtcctgtcca 664620 cagtttctct tgtccctccc tcctgtccgt ggtggctcac aggtctctga ccaggtttca 664680 gcaccatggc aagctctgtc acaccctgaa aggtaaccag gaaacacaga ctctgacaca 664740 gaaggtgcac accccaaccc ctctcctctc ttggtcttcc cacccctagt tcaccctgag 664800 gactgttatc cttgagaaga ataagacaga gaacaagggg ctctcctgtg tccccacacc 664860 tcctcctatt caccaacatg aagggcccgc tccctctccc agctacctct ccattgttaa 664920 acctttcatg taattcacct ccagaacttt cagtcacctt cactcattct ggtctttagc 664980 ctctaacagc acttcttcat accaagtcca ctctcttata ttagtccttg ttgctcttgc 665040 atccactgga tttggggtat ctgaccccca aggcgagctc cccagcaagc acccagcgca 665100 gtctcactgg ctcctgtcag ctcttcactc cttcctcacc tcacagaggc tgcagtggga 665160 ctctgaactg ccccatcctc ctacaccacc agtctccctg gagcaagcca tggcatcccg 665220 cccactcttt cgtgaatgct tctgacatct tcctaaacca ggctgcaact ccgagcctat 665280 acagccctct cagtcttcct acaaacccac agatggtaca gtcattcttg gccaaagttt 665340 tcttctctta catttgacca aacgatttct gtgcattgtc aagtcaataa tttgccagaa 665400 ggtcttcttc taggcatacg agattttcag caggtgcccg gaaatatcaa aatcctgtct 665460 tattaggtgt tttcagagag tatgtggagg tcatgcatta cagaaaaatg accttgaact 665520 tggagataac acaggcgagg ccaaatccca gcccttcttg ttaccagcta tgtaacaggg 665580 cttgagtttc ttgactttca ctaaggaaat aaaaacctta ccttgacagg atgttgtaca 665640 attttaatca aatgaagcag tctgtccaaa ctatacatcg gaatgaccaa gatagggagc 665700 ctttttaaaa gcacaggttt ctgggcacca ttccccagag actctggttt ggtaggtctg 665760 aaagcagaat tatcaaaaag ccccaaggtg tttccaatgt gcccacagat ttggggccac 665820 agaagtcacg tttgaaaatg cccagcacat tgacctgatg ggaggaggaa actgaaaatt 665880 gagatataaa tataactagg aagaatgcac cattgaccca ataaaaaagt tcttaggcgt 665940 aaaacacaaa cagaaatgta tgcatggaca tccaagatct gaaaagtggc aagtgtgact 666000 ggggagagtc tgggaaggcc acggacagga gggtgaggat gggctttgta acgggtcccc 666060 cagcccattg gagggagtta gtggtagttg ctacagacag ggtgcaaacg cagcatcaga 666120 gaggatttat aagtcacact gggagactgt tgaacaaggt gacatcactg agataggggc 666180 tgagctaaag gaacctatag ggcatggatg tggaggtgcc cagtgaccac caagagggga 666240 ctgtccccac cctacccagg tccaccatat gccttggatt ggtgtaaggg actgcagtca 666300 tggacactca tatgcctctc caggctgcct gccaactccc agacaagagc ctccagtgaa 666360 gatggctgta tcttcattgg ccccgtcagt ttcagaaact tcaatgttgc ctgggcagag 666420 gcatcaacca ccacaactgc ctacttcctc caggggctac ttagcaaatg tctctgcatc 666480 ttgtggcacc tggcattcct cctcatcctc ctaaacatct ctgcagaagg tctggctttc 666540 tctctgtggg acaagcctca taggtgtgtg ccgtttcatt gatataaaat ttcctctcct 666600 catttgtctt ccattgaatc ccattcttcc ccttgtcaat ttttttccaa ctctttgtat 666660 ttcatgtttt tccacctcta atcttcttga ccccaaatat gctttttcct tctaactgca 666720 atattcattg tcagattcta ttaggcttca ttctctgaga agttacagta tccaaaagca 666780 gtctttaagc cacatatttt ttcttcaatt ccagaaaatc tcttgcattt atgtttaact 666840 ctggacagag aagtccccta aactgccata ctcaccctta gtgtgacaaa gtgattggcc 666900 ccattcccaa gactcagagg tccatgtatt tgtggtttat ttgttcctct attaaacatt 666960 catgtactat ttgtctacta tgagccaggc actgtgctag cactagggat aaaagactgg 667020 gtatggccag catggcctct gccctcctgg agcttaaagt ctagcaggga acacagattc 667080 agattatcca tggaagactt acttgtgtgg tgagcaccac caaggcagac cctgaggagg 667140 gtgggaatat gtaggcacca tctctgtcta ctgtcttggg ccctcctttt ttcatcccca 667200 gccaatacca gctgtcgacc acacacctac agtcaacaac tgcccaaact cttttgatat 667260 aagaaccacg tattgacatt ctcatccttg cttgaagcct gaaaaccacc agatacaaaa 667320 tgtcacagat tcagtgataa catttcacac aaagtaggtg ctgctgttat aattagctgt 667380 ggttgaaaaa taattcctac aaccaaggat ttggcactaa atgatttcaa aaaatagaac 667440 tgaaaaaata tgtttggtaa tcaggattta ttctggaact tgagattggt ttgtatggga 667500 ttatcttgtt tttaccacac tctatttggg gaggaaagga tctgatatgg cttgaagttt 667560 tgctggtttt caaatgccag ggattttggg ggggcccagg ggtactatcc aaaccatagt 667620 tcattgtact gtcctataca atgagtgctt acagtggcca tcgtccattc cactaacctg 667680 agcttccacc actggaattt gccttctgag atctccccca gtcggctgat ctgtgcttcc 667740 tccatcaccc ctccctgaac tcagctggct tgttgcccca tgtccctcgc agcgtgaata 667800 atgtgtgtgg gatgtcacat cccctctgat ggccaactct gccagaaagc tgggaacatt 667860 gcattcagaa atcactttga gtgtaatttt tctttctttc cgtctttttt tttttttttt 667920 tttttttttg gtttttaatt cctacttgtg aactttcaaa ggcagaggaa aaaaactcac 667980 gtctctatct cttctttttt gaaaaacaaa acccaaaaga ctcctgggat tctgctcaga 668040 gaaccaaaga tgtttcccct cagctgaact cggccaccat cattgatatc cacccttcct 668100 ccacctacag catccgcatg tacgccaaga accggattgg caagagcgag cccagcaacg 668160 agctcaccat cacggcggac gaggcaggta cgtgggaccg ggcggaacct tgctccagag 668220 gagcccggga gctaactctt gagggctcag atgcttaaat gcagaagcag acctttgccc 668280 gtgctaggcg gaggtctttg atgcgtgctc tccgtagttc tgtgccctat aaaaaacgca 668340 gacagcgctc tgcatcttac tttgaaggca ctgctcttca aataggattt agttcaagtt 668400 tcccataccc aagacttaaa agaaagacgt atgaggctaa caatctggtg agattcaaag 668460 aatcatgccg ttttacaatt cctttgtttg gacacatgga atccaggttg acaggagaac 668520 cgtgagtgtg tttctttcct gagaccctgt gaagtccagt gtgggaggaa gcagtaatgc 668580 ttaactagga atctgcaagc atgcttactg tgcgggagat gtgggaaggg gaacagatta 668640 ttttattgac tagaaacatc aatatttaaa aataatgttt ttgctctttt ttctattaca 668700 aacaacatta tatttagtgt tgcaaattca gaagatagag ataagcattg tggagaaggc 668760 aaaacagctt ccatcatttt cccactgaga gctaacccag gaacaggcag tgataactgg 668820 ctaaataatt tcatcaccca cacacgcaca tgcacacagg cacgcaccag tgtattcaca 668880 ccccttaaca cactgcgagc cactcatgtt tccggggggg tgaaattaac aggtgtgcag 668940 agaactgagc aatcaggcaa tggtccatga atgctgattg tcagcccgcc tcctggcagg 669000 aggagaggaa gccactgcgc ttgggtttca tccacaagga ttgcatgcct ggcccattta 669060 ttgtagggaa agggtgtcca gctcccaaac ctacctcttc ttttcctgcc caccatcaga 669120 gcaatcagcc actccctact gcagggaaga tggcagctta gtctcaagtc cctgtttctc 669180 catcaccaag attaaggtga ttgccacacc cagatggcta acagaagacc ggaggtttgt 669240 tgcaactttc aagagaggtt gatcttggct tccttcccac cacctcatct ctgctaccct 669300 cattaacagc atcccaaata taaatggagc ttatgtatct cttaagtact tttctacaat 669360 ttgtaatgat atctctcact atgtgtttaa caaatctcat attgccaaac gggtcaatta 669420 ttttcgagtt ttcattagta taaacaccac tacaatgaac atcctggtgg tatgtctttt 669480 gctatctcca agatcatttt cttagattaa atcctaagaa gtcagatggc tggatcaatc 669540 aaatgcaaca ttttcaccct tctgatatct gtaatcagtg ttgtcttcaa gagaataggt 669600 taaaatgtac aactcttcct gaactgcaga ggaatgccca tttttcaatg ctggaagatg 669660 tcagttcttg aaaattgttt tcaagagtga gtgacagaag atctttaggc tgaagtgcct 669720 gagagtgagc catttctgag acttggattc tctgtatgat ttctcatctg caaaatggac 669780 attatgatgc ctttctgctc cttacacaga catatctgat cactgaaaaa aactcaagct 669840 ctgaaaatac tttgcatgtc tcagaaataa gtgggaaata agtgttaatc tgcttctgca 669900 aaaaatagaa ttgtatttaa ttatgtatgt aaacaaccca ctaacttcct cagatccctg 669960 agatttcatt atgctgggta cttagggaga ataagctgtc cccatccttc agcccaaaat 670020 gtcatctctg acttcctgct caatcttctc cttctctctc aagccctttt ctaatctcgc 670080 cccatcccag ccacctcctc gggaaaacag catttttccg gtggtgcatt ttgcacctgc 670140 ttttctgatt gccattatta atgctgctgt tgttgctttt ttcttcgttt cctctgtgac 670200 ctctgctgcg gctggcagtt gccatggaag cagctctctc cctgccagaa ggccaggtga 670260 agagcctctg gggtgctggt ctgcagggca gctgcctggc atgtctgcag acagatgcag 670320 atgctgcctc tttggctccc aggctggcct tttgtattgt atctgggtgt gctggctgtg 670380 gcagccccac acagcccctc tcctttaata ttcagaggag ctaaggggaa gggaaggaaa 670440 ggagcaggtt ctagaaatga aaagctacag cagataactt gtctttgtct tggttcatag 670500 gtttgcatga ctgaaattaa aaagtcaatt tcccatgtgt gacttaccta gaatggggtg 670560 ctctggccaa aggcatcctc attagagtat tgagcagggg ctgtagacac tgctgcccct 670620 tcccagcagg taaacccaaa ggcacatctt tttaggagct gtagctgtct tgaggtgacc 670680 ttgtcccact gttcccttat tcctcatatg ggagcctccg gaagctgtca gcccactcac 670740 ttttactgta atctagtacc caagtcttgg gcacacgagg atgcccccca atgctactac 670800 tttgcaatga cacttagtga ctccccagag cccaatgccc agcactcacc tgcctttgca 670860 tgctcccaga cccctattgt tgtgcttctt cccctgtctt gaaggcacta caagttccat 670920 gtctcctttt ctgtgccctt ccttgaaaag tcaagttcaa gaatgccttc ctccctggtg 670980 caatgccttt ttccatctcc catgtgtagt tagggactac tcagctcagg acagaggagg 671040 gattttgctg acagtagcct ttgaggtgta tcatcatgtc ttcatggacc ctgctgtcca 671100 tgatgatata ccacctgatg tggaggggct gtggccccct ccacatcagg gggcatatgt 671160 gcttacaatt ctgtcccttg tgtgtgtctg gcataaggga gatgaaagta tgagatgaac 671220 gtttataaac attacccaca gtattgcctt tagaatgggt gtcacaatga gcagagtatg 671280 tgtgtgtgcg tgtgtgtgtg tgtgcgtgtg tgtgtgtgtg tgtgtgtgtg tgtatgtgtg 671340 tgttgagaaa atatatgctg gattaaaccc acagtgaaat tctgaagggt gccctggtct 671400 gaatgttcat gccttccctt tcaaatgaat atcctgaaac ctaattccta atgcaataat 671460 attaagaagt ggggccttta ggaagtgagg gtggacccat cattaatagc atcagtatgc 671520 ccttatacaa taggcccaag gcccaataag atcacttacc ccttctgccc cgggaggaca 671580 tgggaagaag gcactatcta tgaaccagaa gaatgagccc tgaccagaca ccaaatctgg 671640 catcttgatc ttggaattgt cagcctctag aaataaattt ctgtaagaaa taaacttctg 671700 agccaggcac ggtagttcac gcctataatc ccaacacttt gggaggctga ggcaggggga 671760 tcacttgagg tcaggagttc gagaccagcc tggccgacat ggctaaactc cgtctctact 671820 aaaaatacaa aaaaaaatta gccatgcatt gtggcacatg cctgtaatcc cagctacttg 671880 ggaggctgag acaggagaat cgcttgaacc ctggaggcgg aggttgcagt gagccaaggt 671940 cgtgccactg cactccagcc tgggcaacag agtgagactc cttgtcaaaa aaagaaacag 672000 aaataaataa acttctgtgg tgtataagtc atgcagttta gagtactttg ttatagcagc 672060 cccaaaagac taagacaagg acttcatgca gaaaagtaga gaaaggtgaa agataggaca 672120 ggaaggctga gaggaaagaa gatggggaaa gaatacagcc cccatcagag ctccagtgac 672180 cacccatgaa atggctgcat ctggagcttg aggtgccctc cccgcatcct gatggaatag 672240 ggcatgtccc aggccataag ctgcagccca cgacagacca ggcctgtgga tgtgagtcgg 672300 ctcagtgttg tgcgaaactt ttaaattcga tgttaatttt taaaatctgg aaatttcagc 672360 tgaaaatcta aattttgagt tcctcttgag ttcctgcttg gcagcaatga gctggagtta 672420 agcatggagt ggccatccca gaggctgacc ataccccctc agtgagccat agttcccatc 672480 ctccattcat tgaaggatca gcaaactaca gtcggtgagc caaacttcac ctacagacct 672540 tgaactaagc atagtttttt catctttaaa aaaaaaaaaa aagaataaca tgggcccata 672600 aagcccaaaa tttgtactat ctgagtcttt acagaaatgt ttatggatct ctgatgaagt 672660 ctggccacca tgggaatttg agttttagat ttctgctgta tctactgcaa agcttagtga 672720 ggaagggatt gctgccactg gcatagtgtc cctacctaat gttgggaaat ctcattgctc 672780 caaccccaaa ctactcagtt tatttgcatg tgttgcatgt gaaagtgcat aaagcgttat 672840 cataccactt taatacactc gacctcagag aatagccatg aagccaagac cacaccattc 672900 agcgcagtct tcatggcttc cccaaccacc cctagcacca gcagccccca caacaaagga 672960 gcagtcaaga gaataagtga cacagtcgga gttaatgaga tgagctgtta atggacccga 673020 agtgtgtctc tttgacacgg atcagccacg tgacacatga cattcacagc taacccttgc 673080 tacagaccaa cttccccatt agcagctgcc ccctgcaggt catgagtcac ttagtgcctt 673140 gtgaccgagt ttgggatggc tgcccccttc attattttca ctataaatct gtgcatagaa 673200 catgcagctt caattagtgg gtgctcattg aaacaccact gaatttgaca gaccatcaga 673260 gaatagaagg tgtggattat ggaagggtca tgatgcagag tcactgggtt tccaatgaat 673320 ctggcactga gttaagtcct tgcctcatct ttcctcccat tccggggcag cagctgtgat 673380 ctggaagaag agtttcctat gtgctgagct ggggtggagg ggagaggatg gaatgagggc 673440 agaaggaata aaagtcagga gcatgtgaag caaacacagg gctagcagtg ctcattagtg 673500 cagagggcgg catcaatgtg ttcttcagta agagtcaaat gcacagcatt cactcagcga 673560 gaagagccga gcacacccca tgaccaacca ggccctcagc gatctgcctc tgtagatttt 673620 tgtcattctc ctccatcctg ggtttgaaga aactttggga attaaatcta aagaaagtta 673680 tcggccttct tgctgtccct catacacatt gtgtataccc ctgtctgcta tcctgaaagg 673740 ttctggaaca gttctggaat gttctgaaat gttcttcgtc tcttccctta ccactttcaa 673800 atattattct ccaagaatcc aatcctggcc accctattaa aattcaaccc actgcccact 673860 ccactgggtc ccctgcctcc cttaccactc tccttctagc agtcgcttgt atcagcaccc 673920 agtgtactgt ataagttgtt gatttatttt gcttatggtc tgctttgatc ccatcccacc 673980 agggcaggtg gagttgcttg ttctgctcac tcactgctgt atcccaggca cctagattgg 674040 tgtttagcac ataggatgtg ctaattaaat aagtaggtta aataaatcag ccatttattt 674100 aataagtagt tattacatga cttcagcctt tccccatctg ggcaccagct attctttgtc 674160 gtattttgat ttttactaaa tactgtcttg gttccctttg tccaacacag agcatgcctc 674220 tcgcccaccc acccaactcc tgtagaagac aaacgtgtgt ttgtagaatt atgcagctgc 674280 tcctcactac tttttaaaaa tttatatatt tttttctgct tttgtatccc agtctttgcc 674340 tagtttagga cctggcacat agaaggcaaa tctcccaatc agaaccagag gcaaaaatgt 674400 gggactggtt ctcactgggg tgattgagcc catatcaatt aatgatgagg ccccaagatg 674460 ctggctaaag ccaagatatt gagacaggga ggagagtatt ttggagcaga atggagcacc 674520 gaggcttgag tctcagctct gggagggaca caggagctgc tgggcagtgg gaggttgtcc 674580 agctggggag ggacagaagc agagacagcg tagccaggaa ggatcaggac agggaagcaa 674640 agcggagatc catgcgtttg gcaatcagga ggtgcctgtc atccctgtgt tttcagccaa 674700 acagaatgaa ttgtcctgac ttttaccttt gcaaacataa tacaaattat aaagatagtc 674760 ttcgcttatt actgctttac agatcgaaga gttttggatt tcttagaaat gcagagttta 674820 ttttgtaaaa tcacttgttt tttgtgagat ggagtcttgc tctgttgccc agactggagt 674880 gcaatggcac aatctcagct cactacaacc tccgcctcct gggttcaagc ggttatcctg 674940 cctcagcctc cccagtagct gggattatgg gcatgtacca ctgcacccag caaatttgtg 675000 tatttttagt agagaccatg tttcaccatg ttggcaaggc tggtcttgag ctcctgacct 675060 caggtcatct gcccactttg gcttccaaag tggggaagcc aattctgctt tttctatata 675120 ttacatttga aaccatgtaa gtaaattctt aaatttccaa tgtcaacaca attttcaaat 675180 ttagttaaat aaatggatat acctaatttt tgacccttaa tacattttgc attggaaact 675240 caatcggctt tggactgtaa ttttataggc atcattggca atgagatgat aacctatgaa 675300 aaaattacag ctcaggagtt atacagaaag caataaaatt cttaaagaag ggaaattttt 675360 tataatttaa aaaattttta aagtaatgtt ttagaaacat agtagaaaat ttagtgccct 675420 ttgtaaaaca caagcaaaca aaaaaccttc ctaatgatat tggacatagc cctattgtgt 675480 gtttgtacaa attaaattat tttggtttgt ctggactgtt ttcatcactt tttttttttt 675540 tttaggagga gggatccaaa tgctttcact tcagggaaca ggcagaacaa taaatacatt 675600 actgacaaat catggcagca ttggtaggct aagtaataaa gctgttacat tcttaaaaac 675660 agttaagtct gtcctggata caagaactgt accccctctc ctcttcagtg gggaccttca 675720 taaaatacca gacctgggcc tggcatggtg gctcacacct gtaatcccag cactttggga 675780 ggctgaggcg ggcggatcac ttgaggccag gagttcgaga ccagcctggg caacatggcg 675840 aaaccccatc tctactaaaa atgcaaaagt cagccaggcg tggtggcaca cacctgtaat 675900 cccaactact tgggagattg aagcaggaga atagcttgaa cctgggcggt agaggttgca 675960 gtgagtcgag atagtgccac tgcattctag cctgggcgac agagtgagac cctgtctcaa 676020 gaaaaataaa ataaatacca gaccagattg gaaaagtaag ttactcccaa ttcatgatta 676080 cattatgata tgtatgctat ctgatagaat tggggacatt cttgtaaaca ctatgctggc 676140 acctttggtt taattatgaa tatatctcaa ctggaaaatc aaggttgcaa ctcttgtgtg 676200 ccatcttcct gagaggacca caccaaaggc catgccccag ggagcccaga ggattcagga 676260 tgagacagtg ctcctgacat tgcctccaat tcctaacaaa ctggcttctt gtcaaattca 676320 gttaagtgta actaaattaa agtaacccag cctcagtata gctgtcagac tcaaaaatca 676380 tttttcaagg atttttatgg aaaaccgtgt gcttttcaat gagcacagaa ttatctgtgt 676440 gtgagggaaa tccattccat gagtttttat tgaatttgag gtccaaagtt tcctgcctaa 676500 gagcttgacc ccatgtgcaa gaaattgggt gcagaggctc aacaataatc atcaccatta 676560 gctggaagcc attctctccc tcggctcctg ttctggactt taacttcagt tctagcagag 676620 cctttgcatt tttggaacta atagatctga gaggctgtag cactccagac tgccagctgt 676680 ccctggacct gctgaggaga gggatgcatg ctcagcattt cagcatctac aaattgcttt 676740 acccattcaa agcaaggact cactctgggc ttagttcctg gtgccatgta gagtctgctg 676800 ggtgaccaga gacatgcaaa gacagacacg caaacatata tgcacactac agggacaggt 676860 ccccaggcct aggcaggtgt cagctgcagc gggaggctca caggcatggg cggcaaaccc 676920 tgatggaggg agaagaaagc cccagggaaa aggctcggct ctacccaggg gtcccgtgtg 676980 ttttggacat ggctgggaca cagggtgcat agggagtgcg cggaacgaaa gcgtggagag 677040 gacggcgagg tgccttctgg gagcagaaaa ttactagggt gggtgaacag tgtgaattgt 677100 gctctggggc catgtccctt ttaaaagagt acaatagaga ccagaattaa tgtttaggaa 677160 ctaaatagaa actgtcacca ggcatagaag tggggtggga gtggggtatc agagtgagag 677220 atagggatcc ccataaggac gatggtggag aaagcatagg acaggggcca tttggatcag 677280 atgtcaggga cagcatcagc aagtgtgtga aggaggggtg cagggaacaa acagcccaga 677340 gacctaaccc ccacctcctc tctctccagc tcttgtcttt taacaccttt gttttaatta 677400 taagtacatc ttaactggaa aatcgaggcc gcaatgtccc catttccttt caaactcata 677460 tttctaaacc ataacaaacc acatatgctg gagaatcggc ttcgtttctt ggcattctta 677520 tagtatcatt ctctcccagt cccgccagcc ctgacctgcg gaatcagctt cctgcttggt 677580 cctcagtgcg aggacggagc tgtggagtcc cattatcctc ttggagtagc aatccctgca 677640 tcttagagca ctgactcctg gggaggggca ccttgataga gcgccttagt gccctaagac 677700 acagggtgca cccttttcta tagaccatag ccattttcca agactttgtt ttgttccaaa 677760 gcccataact ctctccttca tgttcccatt ctgatttcct gcttggctta ttgtcatatt 677820 gttgagaaaa gcaacaatca ggtttcaacc cgcttctttc aaccagtaag tttacctgtg 677880 tctgccctca cctggcttcc ctcaaccagt aagcctacct aaggcctccc gtcgctctgc 677940 cctcctccca tcccagaggt atttgttcct ttgccccact cactccatag cctgtatctt 678000 ctgccctctt cagtttctgc caggacattc attattcctt caagtttacc ttttgttgtt 678060 gttgttaaat ttctcccatt tgcttccccc tatttacaaa cacttaatga taattatatt 678120 atgattatga tttcttatat ttactgagca cattgttttc ataacaaccc tatgatacaa 678180 attccattgg cccattatat atagagagaa atggagtcac agacaagcta agtaacccgc 678240 agaaaaagca cacagccaac aagtgataga accagaatgt gaacttggac agaaaaaact 678300 caaatggccc atcaacttag caactacatc atgctactac tcagaacttc ctcttccttt 678360 ataaaaaagg aagggagctt tcccttagtc atgcgcttcc ccaaatctac cctttatcta 678420 taagatagct ttacttttcc cattacttcc aaactcccca aaatgagttc atatccacta 678480 cttcagcttt cttatctccc gtgtgccata caaccttttg caaatgtcca cagaactggc 678540 tttctgtagt tctgcagtga tctaaaaatt gtcaatccaa aaacattttt taatctaaag 678600 gattctttcc ctctgatctc tgtgtcgtca tttgcttctg cttctcagaa gacacctgtt 678660 ttcctgctgc cttgcattgc aaccttcttt cagtgtgtgt atctcatagc tctgattaca 678720 ttctgaactc ttggttggca aaatgtttta catctcttag ttctacacca tgtacctagt 678780 aggtagcaca tttccaacac atgcctatca gctctaactg ggatgtaatt ggaattgtct 678840 ctcattggct ccctgtaatt gagattgtct ctcattggcc ccctgtaatt gggattgtct 678900 ctcattggcc cactgactta ttgcacactc agcagaaata ggttgcttta aattgcacac 678960 ttttgtttcc tctttaacat tgcttcagca ctctgtggct agagcccctg gttcacaagg 679020 gtttttttgt tgttttttgt ttgtttatgt tttgagatgg agtctcactc tgtcgcccag 679080 gctggagtgc agtggcgcaa tctcggctta ctgcaacgtc tgcctcctgg attcaagcaa 679140 ttctacctca gcctcccgag tagctgggac tacaggtgca tgccaccaca cccagctaat 679200 tttttgtatt ttagtagaga tggggtttca tcgtgttagc caggatggtc tcaatctcct 679260 gatctcgtga ttgcccgcgt cggcctccca gagtgctggg attacaggcg tgagccaccg 679320 tgcccggcca caagggtttt taattgaaga acaaaagcca tgaaagacac ccaaaggcag 679380 aagaatcttg attatttttg cccgaagtca ttctaatcaa ttgagaaacc ccaataccac 679440 atcactaagc aaagcttcca gcggggagag aaggaccttc aatacacacc atagacagca 679500 tttcataagg gaaattttgt tttgcaactt tctgttgtac cccttgttca aaattgggat 679560 tgattcacga ggttgtcaaa gacatggtga gaaggaatac catgataggt ccccaagatt 679620 catgtttcca aagagcaaat aaacaaaggc ctagagttgg acacagtaat tctacaaaat 679680 tgacatttcc catgaccgct aaaaacttct ttctctgtgc caaacatagg gatgggttgt 679740 cctcggggac cacctttggc tgtgtaggct tcgatctgct ccggaaagcg tctctaacct 679800 gcctgtgggt ttttggtcct tacagctcct gatggtccac ctcaggaagt tcacctggag 679860 cctatatcat ctcagagcat cagggtcaca tggaaggtaa actcagcaaa catttgtatt 679920 ctcggtgctt tccccccagg gcgagccctt cactcctgtt cagtgttatg acaccaagac 679980 tctcgaattt tacaaaactt ttattttttc aaaattaagt tgaaagccct tttcttaaaa 680040 tgcagtattt gtatccacat tttgaatact tttacagcaa attctgtgtc tcagagaata 680100 aagtggttgt atcttttttt tttttcttcc ttgaatcttg atcaaggtct aagcagtggt 680160 ctctacagaa atagtaaaat tgatgtccct gactgcatgc tctcatttca tcccagcaaa 680220 aatgttttca aattgctttt tttaaatggc aaagcatgcg gtggcagaca gtccaccgag 680280 gtggcagaaa acaggccaag tcctcactgt gccactaact agatgtgttc tcaagaaagc 680340 ccctaaattt tcttgccagt gaagtgagct gttgaatcca ctgactccca gggcagtgct 680400 accccatgtg tggcccatag aggcagactg gctgctggtt actttagtgt ttgttggaag 680460 tagctgggag agaaagaaag cttgagccac agtgtaaaca attgcatcac taagcacatc 680520 gtttcattca acagccatgg tttccatagc aaattttctc aagtaaggaa gcagtgttga 680580 ttctggagca agctcatcac caaccaccac tgttccatgg ccttcaggtc agtagcatgg 680640 ccctgacctg gtgggccatg gcattagtca tcctcctgaa tgtgctcttg gagatggctc 680700 tgtcttaggc caaattccgt ttcatccaga acgttattat cgaatcaaaa gttctgtaac 680760 attgcattaa ctatccccgc tctgaatttc tctcatggca tgtgattttt tttcttgtct 680820 ctttcctcac cgtttttttt ctgtggcgtc actgggagaa gagggcagcc aacaactaca 680880 ataaggtctt cacatcacac acctcttcta accattgcat ctgtttgttt gtttgattgt 680940 ttgtttgttt tccttctagt atgggttctt tcataagatg accagcctct gtaacaaaaa 681000 tggattttca ttgttggggc ggataccacc tttggtatta cgggcgttaa tgcagcgagc 681060 ccctttgtgt cagcgtttct caaccgcagc caatgagttg tgtttccagc gggcagcgtg 681120 atatgactgt ttagctgcat agaaagtgca ggccgaggag tgtgggaggt ggtgtcattg 681180 gtctttgtaa gcacatccac cccctgcgag catcacacac attgtagaat aaagacgctc 681240 agcaagccat aaccccacac gcattcccgc cactctacaa atggaatgct gactcactct 681300 gtcttgaatt gaagactgtg aagttttacc cactagcttt acacattctc tcgtgttttg 681360 ccctgaaaaa gaccaggtat tactgtggcc tcaaaagctt tttggatctt ttgggtcctg 681420 catgagagag gtgtctgtcc acagaggatc tagctcttat aactaaaaat ggaaacttct 681480 gaggctttaa aaggcattgt atcctttctc tctctgtaga aagcagccac aaaagtcagt 681540 gcattgcagt taaatttctc tttagtgcca aagggtgaaa tgttgtggga ctattaaaag 681600 gaagcctggc tctcattaga ttgtgaatcg actgaataca ttgttcatgg aggagtgcaa 681660 tctatctctg tagtgggcct ttgtggcatg gcctgtcagc aggcagactt gccggtgatc 681720 taactgacta atgaggttgg ggctgccctg tcaccagctt agcatttcac atcggcctgt 681780 ttatataatg agcttttaaa ggacaccact gattcaatcg aattggacac tattacacga 681840 aatcttaagt atatgtaaag gacaatatgt tacatataac atgcctttat ttatggcata 681900 aaattcagaa tatctgtttt gtgtaaggag aaagaaagaa ggagaaatag cgttagcccc 681960 aaagagggag ccccacatct gtcagccacg gtggacatat gcagtcgtgg gaagtctaag 682020 gtggaagctc attcatggtc acggacactg atcagaagta aaagatgcat tcagtacaga 682080 gacacagggt aaaggaggaa atagctctgg ggttttggtg ggaaaatagc catttagact 682140 ctaagccttt gaaaggtaag gggcactttg gtggcctttc tgtaacactg gagatagata 682200 ttacatttat ttaattatca ttgaataagc actgcttctg taatgacacc ctctattgat 682260 caaaataagc aactttccac ttttatttca ttttatttta tttatttatt ttgagacaga 682320 gtctcactct gtcgcccagg ctggagtgca atgacacgat ctttgctcag tgcaacctgt 682380 gtctcccgag ttcaagcaat tctcctgcct cagcctccca agtagctggg attacaggca 682440 tgtgccacca cacccagcta ctttttttgt atttttaata gagacagggg ttttcaccat 682500 gttggccagg ctggtcttga actcctgact tcacgtgatc cacccacctt ggcctcccaa 682560 actgctggga ttacaggcgt gagctaccac acctggcacc ctttttatct tagttatttc 682620 tttcaccaaa gaagagcttc taattttaaa atctttcatg tccagcaaag gttgctcagg 682680 acctagtgaa tgcagccatc ctacatcagc tgcagcacct ggattcaggc cccttatctt 682740 gcctcgcctt cccagggata cctacccaag cagcagtcca caagtgtcat cgtctctcct 682800 gtcagtgttc aggcagtttg taacatgctt acctctcctg tccattcctg ctcatttgag 682860 gctcagattg tgcatgactg cccccatgaa gatgggaatc cccagagtgc aattagagtt 682920 tcaccctcta tgttacccat tgctcttggc gatggctcag ggaggttccc acccagtggc 682980 ttctgcagtc tgtttcatgt gcatcccctc cactgttctg ggagctcctt ggcagcagga 683040 agagaggctt actcagttct gatccctcat ggctggcatg tgttccatga atgaatgaat 683100 gggtaagtga aggagaggtg agtgtatatg tgagctggga atgaagaggc ctagaagaca 683160 agtgttccat atcacaattg cctgtgaagc attacgtgtt tccaagactg ccatggagat 683220 ggcatccccg ctatcaggat ctccagagag caaacatgct gagctcaggt ctaactcatg 683280 atacagtgaa atgccctaga ctatacaacg gcaggcaccc aaagatgtga accacactca 683340 gtacaccagg cgaccaacca cttttcatat gagtttctac tatggtaatt ttcaatatag 683400 tttattgaaa agtaaagggc agtagtggtc caatttgtga taagtttcat gggaaatgga 683460 catcttcaca tcccaaatat aagcccatag aaagatattc aagaggaata tctttctata 683520 ggctatatta tgatgtctat attatgcaag atgaagtctc agaaagggct cttaaatact 683580 tttacaaata ttaagctaat taaagtgcta ccccatgcct tgacagaaat ccaaaagaca 683640 atgtaagcag ttctgaataa aattaaaagt aaatgacaat aaagtttcat ttgacattct 683700 tggagaaaca aaaggatttg tgtaagcaaa tacaatttaa ttcatggcag gttttgtttc 683760 tgattcaaaa tcagaaagaa tatttaaagc tatggataat tgataacata tttgatgaag 683820 tacctgaaca ttgtacaact aaggaattct ttggtttttc agaaaattcc aatttttagt 683880 ttatctccta aagtgtctct tttagcagtg cctgtcacct tctctcctaa tcagtctcag 683940 aatcagctga ccctctttgg atgcaaatta aggacaatgt gattaccagc tacttgtgtg 684000 catgcttgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtttgccat ggtcactcat 684060 aaaataaaac attcattatt tagaatattt aatgattata tacatctcaa aacatttatc 684120 cagagaatgc aatttaagac agagtttttt tcctattgat ataaaatttg tgttgttgtt 684180 ttatttttgc attaaataag aaatctttgc agaaccacag gctgtcccca aaatatgaaa 684240 tggtcaattg cttaaatatt tctgtgctga gaacaattat caaagtgatt acttgcaata 684300 aaaatcctga gaataatttt accatttggc cctcagtatt gtactatctg cgtgaaaatt 684360 ttactgagaa taagcaaaat tctcatttag aattaagaaa gagaggtatg atttctgtaa 684420 aatactaagt tgaatattca gagatttaat taaatttcag taatctgaag aatattttta 684480 accagaatat cacatctcca ctatacccaa taattccagc taattgaggc atcattacaa 684540 cctattaagt ttcagagttg agctcttaca acaggaaaat gactcagtct gtcatttaaa 684600 aacaaaactg ccttatttcc agtgacctcc gtagtcatcg tttaataaac tgcaggctcc 684660 acttgccttc tgcactaaaa tccctctacc ccagggaagt gcaaggtacc ttggaaaagg 684720 cagtcttgga ggcaccttcc agcactagta tttcctggcc aactgggaca gctgtcctta 684780 gagatatttg ctccccgcca ggcacaatgc taaacttctg catgcattat ctcatttgat 684840 ctgtgagctg ggaacaccca gttttgtgca gagggagatc ctgaagtcaa aggaacttac 684900 ccaagttctg aaggctggtg actgtcagat tgaggacttc cacccaggct gcctggttct 684960 gcctcctggg tttctgagca gtcaaccagt taattactag gaagtgccaa gattgtagtt 685020 cgtgcataat aatgctcaat aaatattaac tccctttact attccttgca aactcatgtt 685080 ataaattata cccaacccca taaaaattaa agatatatga aatttacatt cttacgtagt 685140 atccttttct ttccaaattg taaacttaag cttagagtaa ctttcatagt gagtagacac 685200 ccttttttcc tatatcaact gaaattcaaa aaggttgcct tgaaataaac tttacttaat 685260 tcttcaacta tcactttaat ctttaggcta tgaaaaatga caaaagtttg catttgcttt 685320 taggaactaa tccattggtt ctagcattgg ttttataata gccttattga aattcctgaa 685380 caccaacatg tcttacaaat acttaaagaa tttttagccc ttctcatatt aacgagtcta 685440 acctccttcc ttgataacaa gaaaagaaaa aaaaatttca aaatctctgg tcatccgtat 685500 aaagtaagat tgttctttct caactttttt aggtggacta gactctaggt tccgtgaggg 685560 ttgaggacat gtcttgtgtg ttcactgtac cctcagcagg agtgcaatta atatgcgtta 685620 aattaatgca taaaccattt accattgttt acttttatca taaaaggttc atatcaagag 685680 gtggtgcttt taaaaaaaaa actgtggact ttctagaaag ccctaggtga ctaaatttgc 685740 atctttttgg tgtatatgta aactatgcat gtttctttaa tgaagccatg gtgtttattt 685800 ataccatttg gaatgtattc tgcatctctc cgtctataca ttgggttact cctctcggtt 685860 tagccatgtg atgggccttc ttcaaggact ccagttctct gtcccaggac agagctgcca 685920 gcctgcatgc acaaagggtc cggcaggtct cctcaactaa gcaggcagtt cccttggttt 685980 ccagcctaga gcgcagccag gaaaatgctg gctgcatttg caagagctac tcgcagccac 686040 aggggtggaa tctaggtctg atgctcaggc aggctgggaa gagacactat ctgggactgt 686100 cagcctaaga ggcaattctt gattcaaacc ccactgaaaa agctgtacct ctccagcaga 686160 gtggccttga caggacacaa attgaacttg gactaaggct taggaccaag gccgtctgcc 686220 gtcgagccag aaatcctgtt ggatggtttc ttctaagagt ttcacgttga gtctggatga 686280 acacaaaaaa tctaagtgta ggcactttga ttttttgtat aacggttagg ttataagctg 686340 taaagttgca atataacttt agaaggcaag tattgtattt gcctgattta aagagcatat 686400 tatcagaaat gcaaataagg ttgcaactaa aggggtattt tggacatcta ttgacgctca 686460 tccttaggtg ttttcttagt gcatcaacat tacattttta caattggacc aggtcctgaa 686520 gttgtgacac taggtcaaaa attgtgtatg gtcagaatga tattgaaaat gacttaaatt 686580 gtctaataag cacactatgc ataatattca ctaggaagct ttacagtaac atatatatac 686640 aaacatgtaa tattcatagt gaaaactgaa aagtacatgt aaaaatataa gttgacacta 686700 tttcatcaca ttttaaagta acattagcgt aagttaaatc catttccaac aagtaaatta 686760 tatataatta gaatacagtg taaaaagtac tggattaaat ttcagaaaat tagatacgac 686820 acccatctct acacctaaca aaatgacctt aagtcacttg atttgtcatt attggaactt 686880 gaaccctttt ctctagttct gagttgtgtg ttttattcat tatgtcataa ccaagaaagt 686940 agcagtgcat tttaatgatg aattctcctc tctcctcacc tcccagtgct gacttgatag 687000 ccatagagga taacggatgt gggcccactc tggaatccat aaggtggtcc cttgattaac 687060 aaccccgatt tggatcccta tcctagatgc tgattccgcc caccccacca atggctctgg 687120 acagcactgc catttctgat ggcaaatatc tcccaataaa tgtaaatgtg gtgaaatttt 687180 cccaacaaaa aatagaagtt tattttcagt aacctaataa tagatggata gggtcgggca 687240 cagtggcaca tgcctgtaat cccagcattt tgggaagcca aggcgggcag atcacttaac 687300 atcacgagtt cgagaccagc ctggccaaca tggtgaaacc ctatctctat taaaaataca 687360 aaaattagcc aggcatgatg gatcatgcct atagtcgcag ctactcatga ggttgaggca 687420 gaataattcc ttgaacgcta ggagacagag gctgcagtga gccaagattg ctcaactgta 687480 ctctagcctg agtggcagag caagactcgt ctcaaaaatt taattaatta atttttaaaa 687540 atagatgggt aggtagtaat ttaataaaag tattcagaag accatcttag acagttttat 687600 cagttctcat ataatcctaa ctctgctttt cacagagaac aaattggaaa atcaagctaa 687660 agttaatatg gcattgagca ttatgaatgc atggatgcca tccgtacagg gagtgcatag 687720 gtggatatac actgtttaat gtgctgtatt tcctcagaca gcagtcctta agccatctcg 687780 ctgatgacat ttcccatctt ttcagagaaa tcaagtgaga tacataagtt agtaaacagg 687840 gcacagatgt tagaatgaaa aaggaaaaca tatatccaat caagaattac atagacatca 687900 tcaaatggca tctgctatgt catggacccc tctcctaagg caagggaaga aacatgacat 687960 tagttttatt gttattatta tggcaactcg gctggacgaa gttggttagg gtccatcaca 688020 ggaagaaccc cagccaggag ggcacagcta ttttccagac tattttcaag gtagcatgaa 688080 gcaagacaga aaaacacaat gtgtgccttc aaacgtattt cactagttca aatacattta 688140 agttaatgca ctaagatgta acaaactatt tcaagatagc ccataacatt tttaaagcca 688200 aactcttcat tgtattaaaa atgctgaaag ctacttcaaa ttctttcaat tcctgtaata 688260 aactcttcct gttcttttga aaaatttaag ttgagaccaa aaataaaagt actttgtgct 688320 ttgagtaatt atagatgtat aagaaataaa accattttac cttcttgttt tgcctgccag 688380 taacaatttg aagttggaaa cagggtttgt ttttctgtaa ataacagaag aatttaggtg 688440 gcagatcctt agtgaattta ggaaacaaga cttcccactg aaggagagtg tgattcaggg 688500 agtgcctgtg ttgctcccgt gggcccgtgt ggaatctgtg gcacgtgttg catctggact 688560 tgtggagtat ttcccctcaa cataagccag agtgttcaca ggggcccttg gtctgaatgc 688620 ttctagcaca ttcctaacag ggaacataca gtagcctatt ggacaactgt ttcttttctt 688680 tttttctttt cttttgtttt tttgtttttg tttttgtttt gagacagggt ctcactctac 688740 cacccaggct gaatgcagtg tagtggcacc atcctggctc actgcagcct tgaccttcca 688800 ggctcatgtg atcctcctac ctcagcctcc tgagtagctg ggactacaag tgcataccac 688860 catcaccatg cccagttaac tttttgattt ttgtagagac aaggtctcac tatgttgccc 688920 aggctggtct caaattcctg acctgcagcg gtcctcctgc ctcggcctcc taatgtgctg 688980 tgattacagg catgagccac tgtgccttgc ccagacaact ttttcaatat tctcctcgca 689040 aatacctatt catgcatgtt gatgtctaaa attctcttta gtcaaggcta aagcttttca 689100 ttacccaaaa atagataaga ggctaggcat ggtggctcac acctataatc ctagcacttt 689160 caaaggctga attgggagga ttgcttgagc ccacgggttt aagaccagcc tgggcaacat 689220 agtgagacct catctctatc aaaagaaaaa aaatagctgg gtgtggtggt gtgtgcctgt 689280 ggtcccagct gctcaggagg ctgaagtggg agaatcactt gagcctggga ggtcgaggct 689340 gcagtcagct gagatggcat caatgcactc cagcctgggt gacaaggcga gactgtctca 689400 ggaaaaaaaa aaaaaagaaa aaagaaaagg aaagagagac aaagcctagc tctagagaaa 689460 gaatgccatc ctcctcttaa tccctactga gctatagagg gcagatattg aatccaggac 689520 tggagctcca ttgttactgc agacattact attccttgtc ttctgataga acacaagtta 689580 gaactatcca ttggagcatg gataaaagga gagtaacgaa ctctaaccaa cactgggcag 689640 agcccaggcc tttctccaat gctcctttct tagtagtgcc tctcctgtca acctttctcc 689700 cctctctcct tcccaccctg ccttggacct gcagcacacc cagtaagttc tacctcacat 689760 gctggttctg tccacagcac tgtcctgtac gagtctgcaa actgtttctc taatgggcca 689820 gagagcagat attttcagct ttgtaggccc tgcagtctcg gtcttaactg ctcaattctg 689880 ctgcataggc acagctgcag tccatgcgtg gatgagtgaa gacagctggg atccagtaaa 689940 acttcaccta ggaaaggtga aatttgaagt tcacataatt ttcacatgac aaaatattct 690000 tcctcttttg atttttttca atcatttaaa aatgtaagcc acaacaagaa accgttgtta 690060 gctaagagcc acataaaaac aagcagccaa acagatctgg aggagggacc agtttgtcaa 690120 cccttatttc ctggattgag atgatctctc gagagggagc cacatccaac tgagagagtc 690180 tcatctgaga caaggctagc ccctcccgcc atatatgata tatgctaaat catcactctc 690240 cagttcaaag atccacagat ctttggggca ggggcacaat ccctccaacc tctttgctaa 690300 tgcataacag aagtgacctt tgctccagtt cccaataagt tcctcatctc gtcttagaac 690360 tcctcagcct ggacttcttt gcctatatca ctaccaccat tgtgatcata acaatttaac 690420 aagtctctgg gaagttccag actttccctc atcttcctgt cttcttctga gccctcaaca 690480 ctcttccaac ctcagctcat tacccagttc caaagttgct tccatatttt caggtagctt 690540 tatagcagtg ccccactcaa aaatggcttc tggttcattg gttcttttgg cacagatgta 690600 aagcactcag gaattccttc cagttataaa attaaagctc acctttcagt gggcaggctc 690660 cttctgagac ctggatcttc tctggttctt ctgaacagat acttagcaaa aatgacaaag 690720 gctgcaacaa cccggcgtgt gactgatgcc gcttactcct ttacaagccc ctttctctct 690780 ctctctctct ctctctctct ctctctctct ctctctctct ctctctgtct tagtttgact 690840 gtcacagctt ccacctgcct cctggcagtg ccgttcccat ctgtgtgtcc cttccagccc 690900 agggtcactc tcacccgcta ctggctctca gcctcatccc tgtggattcc aggactcagt 690960 ttgtctccat acttaccctc tcctcctaca tcacttaagg gttctcttag ttattcttta 691020 atttatatta ttaaatataa tataaattat attatatata gggtgggagg gaaatggagg 691080 cagttccagt ttaaggacct acagggtaga cagaggctgc cctgtgtgca tgtcagagca 691140 ctggctgggg cgactcctgg cttggctccc tgccttggcc tccagcttcc cacgccctgc 691200 cctccccagt ggaaagggcc tgtttcgttc caaggaagat tcttcttcac cctcctttcc 691260 tgccttttct catcaagaca tccaggatgc ctccagagca tgcagaccca gtggtttgtt 691320 ggggtgagag gtggatgtgg atgtgccttc atctcactca gctccacccc tgcccgactg 691380 acctctttac cagcggtgtt ggatcatgat tggccctccc ctggcgctgt cttacagagc 691440 ttccagaatc agacactgtc ttctcccatc ccgcaaaact acttccgagc atttttcatg 691500 gccccatgac catgcctttg aaatcctgcc tcttgtgctt gtttatcaga ttggagtcgg 691560 ggtgcccctc cctcccttat ctctgtggcc tttctcgggc ccctgccctg ccctccttgg 691620 ccacactgcc gttacagggc ctccattacc tgcagagggg ctactctggg ttgggccctc 691680 caggcgtgtg tggtgggcca aagccctttg ggttcactca gccaccgcta aatagttggg 691740 gcccagcctc aggctcacag actagcatac cccctctttt gcatcagagt gcaccctcta 691800 ggtccccatt gttgggcgcg ggagctaggt gggggtattc ccagaggcca gccctcagag 691860 ttgattcata ggaagcaaag cccgaatgcc cttgtgtggt ccttggcaga gagcactgat 691920 aggcctctgt ggctggtagg aaatgttaac tgtggttagc aggtggtgtg atgtatgagg 691980 aacaacagaa ttcaaaaagg gagtgtccca aaaagaggag ctatgtcaca ggtgtttgtt 692040 ggctggatga ataaagcgga agctgtccta cactttagaa atggaataaa tggagttttg 692100 ctttgcagta gttaacctca attccatgtc ataaaattat caatctattt ctagcattct 692160 gcatttgtgt ctcaaggcaa agcccacata taccttggcc actctttcct cctcagctgc 692220 caagtctgac tagaatatgg cagctgcagc ctgcaagtaa cattcttggc tctcaagaca 692280 gtgcctattt caaataatct gtcatttatc atttatttct caaactgaaa ttgcacagcc 692340 cctttgttct aagcactgtc tcattatcag gtcatgtggc ccttttctat ttcatgaaat 692400 gtggacatct catcctttcc tagctcctca aaagataatg actttggggg agccagtcac 692460 gtggccatac atctacccat tatgagacct aggacacaga tactgtattt aatacagtgc 692520 aactctaagg agagatatat gaacaaaaat atcatttgag accggaagca gtggttcact 692580 gctggtaatc ccagcacttt gggaggctga gttgggcaga ttatttaagc tcaggagttg 692640 gagaccagcc tgggcaacat ggcaaaaacc catctctaca aaaaaagttc aaaaatttgc 692700 cgggtatggt gacatgtctg tgatcccagg tactcaggag gctgaagtgg aaggattatt 692760 tgagcctggg gtggttgagg ctgcagtgag ccatgatccc accactgcac tccagcatgg 692820 gtgacagagt gagaccctgt gaaaaagaaa gaaaaataaa agaaaaagag ggaaggaagg 692880 aaaggaaggg aggaaggaag gaaaggaagg gaggaaggaa ggaaggaagg aagaagaaag 692940 gagaggaaag aaaggagaga ggagaggaaa ggaattattt gaggcaataa tgtaagaggt 693000 ctcctcgacc tgacatagcc ccctcaaaat ccattgtcca tggaccaaga tagccagctg 693060 gttctcacac cacccctata cctattgtaa agcagaatcc ctttagtgct gagtaaggta 693120 gatctttaaa ttactcccaa gaccaggaag gtctaacagt tttatgtgca tttattccct 693180 tttgtttggc caagaaccag gaaaatgggc tactggctaa cctgagaaat gggggaatgc 693240 atagttgctg ctttttaact aaatagtctc tcccagcaaa gccaaatcta aatcactgag 693300 tgactcccag tgataacaac agtgattctc agactcaggg agcactggta tcccctggag 693360 ggctttttaa aacacacctc accaggctcc acccccagag tttattcctg attcaggaac 693420 tctgagtggg tccccagttc ttgcagctct aacagttttc caggtgatgt ggatgttgct 693480 ggtagcgcac cataccacta catacaggct ccataggttc tgtcccgtag atatgtccct 693540 agcttcatct gtgcttgtac cgtcccccac ccctgtgatc accatggata cctcacccca 693600 gagtcacttg agcctctctc cattcctggg tgtcttctgt ccttgcacct gggtgcagct 693660 gtgtatgcca attgctttgg cgacagcatt gtaccctcca aggcaatgtc cagtcaccct 693720 ttagctcagg tgaagtatgc tcttctctgg caatccttct gaccacgatt tgcccctcca 693780 tagtactctg ggcaaacctt cagcactgca agtatcaggc agtattctga gcactgattc 693840 actcaaaggt gtccctggtt gtgccatgcc ttgtgtagaa cagatgccca gttaaggttt 693900 gttcaatgtg atgcacccat tcactgagca agcttatgga atggctactg tttatgttgg 693960 aaagcaggta aggggaggct gcagaaaacg cacaaagatg aaaaagactg tccacccaac 694020 ttgtcacata agggaaatga ggatagatta cattttaagt ggatttggag gaatctataa 694080 agaaaatgtt caattcattt cccaactaaa ttattcagca tgcctgagaa aggcagcatt 694140 cttcaaacgt gaaattctgc agtgaggctc ttagcagact ccagccaaca ggtgaattct 694200 gcacatccag cagaggccat ttcctttcaa tgggaagggg gcaggaggca tgagggaaac 694260 agaacatggc tggtggtctt cagcacaaga gatgcctgtt ctaatcattc acatccaggc 694320 aggtgcagtg agcatttgca cgtctactgt tttactgtcc ctttaaagga tgatgcatct 694380 gccacaggcg gcttgcagcc gactgattga gaaggacata taaaataagt cacttgcaca 694440 ccgtgcaaat acattgacat ggtgcgactg ttgtcatgga gatcaaaaga gaaggtttct 694500 taaaggaagt ggaggttggg agggatttgg aagctggaga aagggcatct gggaggatga 694560 aaggaggctg ttgaggagga ctacaggaga aaaaaacctg ccaggctagg aagggggaga 694620 gagcattcca cagatggcag ataaatgaaa gaaatgagaa gaaatcagga tcattactga 694680 atccaaaggc aaatgaatgg gggagtaaag ttcaacatgg gaaaaacaat ctttgtgtga 694740 gaaacctaac aaggagcagg catgaccttc tcttagattt gcactgcgtt caaggggatt 694800 tgagaagagg caaacagaaa gcactcactt aggaaagaag tcggttgttt gtaaatacgt 694860 cctcaaggat ttctttaact taaacacatt tctaaatttc aacattttcc ctgtggaaag 694920 ggccttgttt tattgagttc ttaaatagga gtagaaggga gcccttagtt ttttgttttt 694980 tttgtgtttt tttttttcca tatgcttacg tttcaaagga ctcctttaat ttgtcttaag 695040 atgactggtt accaggtgag atttgctgta aatctgcagg tccatcatca taaaaacatg 695100 taacccaccg gctggctgag taagtgagca aattctcttt ctggaatcct tcttttaaga 695160 aggaaaaaaa tgaatgacag tgtccaaata aattggctca tcagaagcta ttttcatccc 695220 tggtggggcc tgggcaatga agctcaaccc ctccaaatcc tgcctcaacc tgtcatcctt 695280 ctgtgtaggc cagcaggcta agtcccagtg cggaagccaa ctctcagctt gaatccacac 695340 ttcccggctg tcacactaga ctgctgagtt ctccacttct gtagtggcta agccaggcct 695400 ctcttcaaca gctaaaccat gtgtctgcag tcaaggaatt tcttctgact tcataccctt 695460 gctatcagtc ctttacccag ttagattata aacctgtacc tgtgatcatt cttacccacc 695520 tctttttttt gcatctcatg tgtgttcaaa accattctct tctccatctg caagaatatc 695580 ttctgagaac atccacagtg ttgaagcccc gatttagaca gggggaaata acaagtgaga 695640 tttcattctg tagggttctt tgcattctag agcttgcaat gacattcttt gaaaccacgt 695700 ttcattgaga atggtggcca ctagaggagg tagaagtgat cagtgaatgc cagtggagac 695760 cagggaggga gaaggcttct tggtgggagt ggtctaggga agagccctgg tgagctggaa 695820 gctgagctgg cctgcagaga aggagtagtg ggggtattct ttgaaagaag aaggaagaac 695880 attttttgac aacagctttt ataaggtggg aatatgtaag acagttggga tccccaccct 695940 ttttcaggca gtcagagagg aacgcaggtg agcaagcaac acccaggagg cattagtctt 696000 gagagatgag gcagcgatca gatctcacaa caggtactac tgagatcggg agacagagat 696060 caaagaggca tggtcaaagt ggtttcctag gaaatttgtc ttctccaata ttatgcaact 696120 cagattcaaa atatgtttcc agatccctac ctgatttctt gttttccttt tcttcttacc 696180 ccaccattaa cctcattcac tgagtttcat gaaagtgaac cattatttcc acccatgtat 696240 caattgttct acagtgctaa ttaacaacct taatacagtg ttctaaagat catttcccta 696300 taaggatata ttctctatac cccagaaaac catctccctt tgttcctagt agacacatgc 696360 tccaagcaaa gatgtctaaa gcatcattca aaacaatttt ccagttaagg atcttatgca 696420 ctaatttgcc ttgggaatat gaagcccact gccagacaaa tggattcacg tgtctccact 696480 aagcacacct tccactccta ctgactcatc cataactcag agtgagcctc tagtgtcatt 696540 ttcgaaaacc tgaaccacag gccataacat ttcttacact taatatacaa aatccctaca 696600 tttatggatt tttttcagag gttgttttaa aatacatcca caaggatttc tttaatttaa 696660 atgcatttct aaatttcaat ctgactagtc tatctacaaa ttaataaagt aacttaaact 696720 ttccctgata aagaattttt gcttgctttt atgcataaaa atatacaatt ttctcttcat 696780 gtgatctatt aaattttcct ctgattagaa atgccatgta tactattact ttacaaaact 696840 aacaaacttt gcaaaagggt gaaaagttct ctgaggctct atgagcggtt aataccaaat 696900 acaactttgg agaattccta ccctgtactt gccttgagat agttgtttta acatatttga 696960 ccttttgttt cttcatgtgt aaagaagcat acttatactg tgtggggttt tttagggaaa 697020 gaaaatgaaa taatatacat aaagcaccaa ttacaatggg aaaaaacagt gttcaataag 697080 tggaagtgga ggtggtagag gtagtagtag ttgtggtcat tgtggtggca ttcatgttgg 697140 tgtgggatag taatggaatg atggatggtt gtggtgatag tgatattggt gttgggatag 697200 tgatggaata atggatggtt gtcgttatag tgatgttggc actgggattg tgatggagtg 697260 atggatgttg tggtgacagt ggtgttggtg ttgggattgt gatggagtga tggatggtgg 697320 tggtgacagt ggtgttggtg ttgggatagt gatggagcga tggatgttgt gacagtggtg 697380 ttggtgttgg gatagtgaag aagtaatgga tggtggtggt gatagtgatg gtggtgttgg 697440 gatagtgatg gagcgatgga tggtggtggt gatagtgacg gtggtgttgg gatagtgatg 697500 gagcgatgga tggtggtggt gacagtggtg ttggtgttgg gatagtgatg gagtgatgga 697560 tgttgtggtg acagtggtgt tggtgttggg atagtgatgg agtgatggat gttgtggtga 697620 cagtgctgtt ggtgttggga tagtgatgga gtattggatg ttgtggtgac agtggtattg 697680 gtgttgggat agtgatggag tgatggatgt tgtggtgaca gtggtgttgg tgttgggata 697740 gtgaagaagt aatggatggt ggtggtgata gtgatggtgg tattgggata gtgatgaagt 697800 gacggatggt ggtggtgata gtgatattgg tgttgggata gtgatggagt gatggatggt 697860 tgtggtgata gtgatattgg tgttgggata gtgatggaat gatggatggt tgtggtgatg 697920 gcaatgttgg tgttggaata gtgatggagt gatggatatt tgcggtggta gtgatgttaa 697980 tattggaata gtaatggagt gatggatggt tgtggtgata gttgtgttgg tgttgggata 698040 gtgattgagt gatggatggt ggtggtgata gtgttgttgg ttttgggata gtgataaagt 698100 gaagcatctt tttagtgaca gtgatggtgg taacatcaag gatgatgatg gaagtagtgg 698160 aggttaaagt gtggtttgtt ggtgaagttt gtgataaata tggtggtaaa gttggaagaa 698220 gtgatagagg tgcttctacc attaggttaa ttttatggca gtgatgttga tactggtggt 698280 tgtaatgttg gtgatgtcag tggtagagat gctattgctg gtggtggtgg tgttcacagt 698340 atttttgaca gagatgaagc tggtggtgat gatggtggta aagatggtag tagtgatggt 698400 ggtggcttgg ctgtgtgggg gacctgaggg agtggcattg atgttggcag tggtgacagt 698460 gacctgcaga ggtggtaagc attgattggt ggtggtggtc atcatggtgg aggtgccagt 698520 tagtgttgta attgaaatag aaagataacc tagagatgag ttagcacact acctttgtaa 698580 aaaacagctt tattgagata cagttagcat gccatagcat tccctatttt aagtgtatga 698640 ttcagtggta tttcatatgt ttacagagat gtgcagccgt agccataatt gtaaacattt 698700 gcatcacccc acagagaaag cttgcaacca ctggctgctg ctcccatcct ctcccactac 698760 cttttaagtc tgtttttaaa ccttatagtt tggggacctg caagctatga aactgaaagt 698820 atatgttccc tttataagaa acacatctca cttcttcctc aggtgcaaca atttattctg 698880 catgaaaact atagatcata ttagcaccct gaaaaaaaaa gatgtaaaaa cactactacc 698940 atcaaataac gcataactct actccatata tttcatttca aaattggaat attaagaaaa 699000 atagaggaga gctctcttgt ttgttccttg tgatataatc ccttaactta ccctatgata 699060 ttgcacatct ggaagaataa taatcaaaaa agccctatct cattaacagc caattgaaac 699120 atggacttaa aaaataagat ggtcatctac ttctgggact tgagttcaat aaataaactt 699180 agaaacagag aaactatatt gtgaaggtgt ctaacatagc atttgtggta gtaaataaac 699240 ctggaaacaa taatatcccc aacaattaaa aaaaggttaa ataaaataaa acatcaatat 699300 gatggaatat gatatttaaa gactatgaag taaagatggg aatataatca taatagcata 699360 ttaaatgaag aagaaaaact cagacactaa attgtacagg ctacaaacac agctatgtgg 699420 ggcaaaacac tttactttag ataaatagac tgaaatgcat caaaatgtga atagaattgc 699480 attggataga aatggtggtt gtttactttt attataaaac aaaatgagat aattattcca 699540 cacaatattt tgcagaagta tcaactaaga aaaaataagc tttattttag aaccacagga 699600 ctgaaatgta gttcttctaa gaaaaatgta aagaattttc tttttctttt taacaaaata 699660 ttgaaatgga acagaacaaa aacacctgcg ttgtctatta tagttaagct agttaggatg 699720 ggttttcacc catggagagg aaacaaggga agatttctcc tttctacctg tacaaacaga 699780 tcacaggcag gattaatccc cccaaactgg aggaactaca tgtcagcaag caggtccctt 699840 cattcttgtg gaggatttag ctaaattggt ggctctatga aaacactttc tcacaggcat 699900 ttgactttac tgtctactct tcttgacctg actccacagc ccccatactg tgaatccaac 699960 ttgctgtctt agggaggctt aaagcctcac cgggagccag ttgaacaatt agaatattta 700020 atggatgtaa atctcattta aaaaataata ttattttatt tgggtcacta tatctaacat 700080 taaaacacta ggtaaaatag gggaaatctc tttgttggta aatttgactt ataggtgacg 700140 tttacaggga aattcatttg attaattaat taggtcacat aaatgtaatt cagtggttgc 700200 agcaaaacaa ttttcacata gagtaattga attttcaaaa catagaatct tgaaatctat 700260 ttctaaacag tgagaaaagc catagctcat caatgcaaaa gccagcacat ctgtggattc 700320 agaggagcat agacatttgt ttataataaa aaaggtatga gctcttccac cagggtctaa 700380 ctccgagcca acagatacaa ataaataaat ggtttacgcg actgtttcac tgacacctgc 700440 tggcaccatg aatatactaa attagattgg ctgttgggaa aagcaagtgg agtccaagaa 700500 aaccataaat ggagaaactt gctgtgaaaa acaaaaatga ttttactgct cttggataag 700560 tcagacttac tactaatgac aggctgaggc atggaatccc ctgggaagtt attattaggc 700620 aatccataag tgtttgctga atccatcaat gctgttcatc agctcgaaac cttcttctga 700680 cttctcattg tctgccctcc cccggtcaca tttggcaggt tttcaaggtc ttgctccact 700740 ctgtccgttc cctcctgact taccgctggg caggtgtgca ccctttgcag gctccactca 700800 ccccatcctc cttctacttc tctgagccgt gccccgccac ctccccccct ccgtcaagcc 700860 cacctgggct ctgagtcttc ccaccacttc agaccaccca tactcacact ttctagatgc 700920 ctgctggcct tcactttctt accatgcatt tccacacttc atagttctct acaggttctt 700980 aagtgcttat ttcctctctg caggtcgatt ataaacactt tcaggacgga gaaagctttc 701040 agaggcttga gagatccaga tccatagttt gtacttaaat gtatgtgtgt acgtgtatat 701100 gtatatacat acatatgtac atgtatacat acatacacat gtatgtgtgt atgtatacat 701160 acacgcatac acataaacac acatatctgt tgactgcctg aaagtctaca aaacctttat 701220 tccctagagc ctcatcttgg tggcattcgc atatcttttt ttactttttg agactgagtc 701280 ttgttctgtc acccaggctg gagtgcagtg gggcaatctc agctcactgc aacctccgcc 701340 tcccgggttc aagtgattct cccattttag cctcccaggt agctgggact acagacaccc 701400 accaccatgc ctggctaatt tttgtatttt tagcagagac ggggtttcac catgttggcc 701460 aggctgttct tgaactcctg acctcaagtg atccgcccac ctcagcctcc caaagtggtg 701520 ggattacagg tgtgagccac cgcgcccagc cttataccat ccttgaaaag gctctggttt 701580 ctaaatgagt cctacgcatc agcctaaatc ctactttgac ctggtggacc atcttcacat 701640 cagcagggtg gagttagcac cagcctctct cttgccccac atttaatcac ccccaaatca 701700 ttccagaatg attcggggct tcatgaaaga gattaccttc ctattgggtg tgcactcacc 701760 ttcccatgcc agttttcaac ctggaaacac tgtgattctg ggatatttcc ttagaatgta 701820 agctccatga ggacgggggt cttttctttt gtcttcttac atttccaaac tcaattctat 701880 tccctggtgc ctggaacaag gcctggcaca cagcagcgag cccgagagtt cttgctgggt 701940 gcaggcctga gggtcagtct cacccggtcg taagcgtacc tggagacgcc acaaacatga 702000 tctgtatttt gacactttct cgccagttag acaagtcaac cagtacatca tgaaggacag 702060 aatgagagcg caggctctgg ggcccaacac ccatgttcag attccgctcc tgccatgcat 702120 actcaggtga cctcctgtgt ccattgacgg tccagtggct cagaggggct gggagggccg 702180 gatgcattca caggtaaagg aagggtgcct ggcacagacc aagttgcact gtacgtgggt 702240 ttgcggctgc taccggacca ccgccccagc atcgtggcga tgactccact ttatttctgc 702300 tttcctacgt gggtgtgggc gttgatttcg ctcttgtcct acctcaagac ttctttagtg 702360 tgttcttttc tctcctgttt aggctcccaa gaaacatttg caaaatggga ttatccgtgg 702420 ctaccaaata ggttaccgag agtacagcac tgggggtaac ttccaattca acattatcag 702480 tgtcgacacc agcggggaca gtgaggttta caccctggac aacctgaata agttcactca 702540 gtacggcctg gtggtgcagg cctgtaaccg ggccggcacg gggccttctt ctcaggaaat 702600 catcaccacc actctcgagg atggtaggtt cggccggggc ctggtcgtgg cttttccctc 702660 cgcaaaggtt ccctcgggtc tgccccgggg ctcccccaac ctcgcactcc cccgccccac 702720 gactttgcag tgacctgcag ggcctggggt ctcgggtgga aaagccttcc ctcgtgacct 702780 cgcccacccc gctgatctgc ccgccctggg gcagggctgg actgcaaagc cagcaagtcc 702840 ctcccttttc agactcttcc tcattcattt caggtacaag aattgggctt ttctggagtg 702900 aaaacaaggc tctctctatt actgcagaag tctcacgaga atgcagaaat gctatttgct 702960 aaaaaacttt ctcccaaatg ttaagaaggt tttttaaaat ttattttatt tttcattgtt 703020 tcctattttc aagcattctg agtacagaga aaaggaattt tcagattgca cagtgatcga 703080 tcgcccccta gcggccgaga taaattaatt agcccttcca ccatgtcact gagaataacc 703140 cagaagctca aatttccagt agtgcttgaa aatagagaac cctggtatcc agaggcacag 703200 tgttttaggc aggaagttaa gatatggggt tatttgtagc aataagtggt agctttgaag 703260 gcaggaagct ggcactacat ttacctcttg tgcagttagt catttgatca tagatttttt 703320 tttgagacgg agtccggctc tctctcccag gctggagtgc agtggcgcga tcttggctcg 703380 ctgcaagctc cgcctcccgg gttcacgcca ttctcctgcc tcagcctccc gagtagctgg 703440 gactgcaggc acccgccacc acgcctggct aattttttgt attattagta gagacgggtt 703500 ttcaccgtgt tagccaggat ggtctcgatc tcctgacctc gtgatctgcc cgcctcggcc 703560 tccaaaagtg ctgggattag aggcgtgagc caccgcgccc ggcccttgat cacaggtttg 703620 cggaggcaga taggacttgc acctgtaata tctgacaatt tttgcgagga gaggagtctt 703680 caatgacttg cagcctgaac actggaattg tctatcttca taattgcaat agtcgttaaa 703740 tatgcctttg tttttgcttc aatgctcatt tttcattaag atgcgtgtct cagccagtat 703800 tttgcaccgc cccagcgcca acatttaagg tttacaaaag ctcagtacta aaaatatttt 703860 caatattctt ctgacctgtc tatggtctct cttccctcta gagaaaggga tgaggatgag 703920 acaggagaaa tctatgatta tgtttctact ttttagcact ttacaatggt tcagcttcca 703980 atttatatgc cagatattac taaatacaga ggtaccgtac tctataaagt aaatgcaact 704040 taaagaagta acttccaaga gtaaggggaa aataaatcag acaaacaatg attttctact 704100 caggcaataa aattaagaag ggtacacgac tcaagtccca acaactgtcc taaaagtaaa 704160 gaaactaagt tggaaagaga gactatggaa tccattagaa tatatgcatt gactcatgat 704220 attttactga gcactgagtt atcataagat ttttccaggg aagtgatctt tgttattttt 704280 tctttcattt tggggttgag tgcaattttt tgcttgcata ttgaaatatt aaaatacgtt 704340 gctttttcgg ttattgcttt gctcataaac cacccacagt tattacagat tctaattatt 704400 tgatttcagt gcccagttac ccccccgaaa atgtccaagc catagcaaca tcaccagaaa 704460 gcatatcaat atcctggtcc acactttcca aggaagcctt gaatggaatt ctccaggggt 704520 tcagagtcat ttactgggcc aacctcatgg acggaggtaa gaggactaaa ctaggacttt 704580 gggtttgcct ccagagaatg catgatggaa tttgcagacc cctcctagtt cctaacaagg 704640 ggctcaggat atggcgggca cctctttatc aatagacact ttcccctttt ctgtcatccc 704700 tcatctgaca tttgaacagg tctctttgtt taaaacatca cacaccttcg aaacccaagt 704760 tgaagcctag gcgggggcgg cacttgggaa atttcaacat ggatgtattt tcctaattat 704820 gtctatgtca aggctctgca ggcagcacca aaacctccat ctctatctag aacattctgt 704880 gtgatatgta ttctaaaatg ttggcctctt cctacttccc aaatagaact ccgcggggaa 704940 acgttaaatt tcctgtagtt gtgctgtaag tgggtgtggg aagagtgccc aggcacatgg 705000 aggggggcac tcaggagggg gccaggaagt tcagggccct cccgttttgt ctcctgtttc 705060 tctttctcct cttccttccc cttctcctcc tctctctttt ccttgttctt tatcgtgtgt 705120 gtgtgtgtgt gtgtgtgtat ttcaagtggt agggcaaaat gttcctgttt gtttagggca 705180 aggctttgaa taaacgactt tctcaagtgg acataagatt ggggccacaa gtttcttgca 705240 gcaacacctc agtgtcttcg ccctcaggct gcgagtggtg cccaccaggc tgggccgggc 705300 tgcgtgagtg tgctggggca gagcgaggct gcagccccca gcaggaaagg cctctggaag 705360 cctgctcact gtctctgtcc caagcctggg gggcccacac ctgcctcctc ccctgccctc 705420 catttccagc cccctcctgc accccccgtc actggacagt accttccctc ttgtttgggg 705480 tttcttttct ttttttgaga cagggtctcc ctctgtcacc caggctggag tgcagtggca 705540 cgatctcagc tcactgcaac tctccacctc cccgggccca agcaattctc ctgcctcagc 705600 ctcccaagta gctaggattg caggcgtgca ccaccacacc tggctaattt tcagtatttt 705660 tagtagagat ggggtttcgc cagcttggcc aggctggtct tgaactcctg gcctcaagtg 705720 atctgcccac cttggcctcc caaagtgctg ggattacagg cgtgacccac cacgcccagc 705780 ctggggcttc tttcaacccc tctgactggg tgtgatccct gatgagtgct cacctctaat 705840 tttgggcaaa tgcggtcaag gacctatccc ttccctgctc aggaccacct ggatctgttc 705900 taccaggcag acccctgtcc ccatgcaggt aaacataggg ctccacaggt ggcagcagcc 705960 tccacggttg gtgcaacagt aaaggcaaga agacacatga gcagcacaag cattactggc 706020 tcagcgagca taggcctttg agccttagct ctgcatgtcc ctaactgtgt ccctaacatg 706080 tgtttctcag gactgagagc agacctcatg cctttgttgc cacatgtagt acctggagca 706140 ctaccagcca tgggaggcaa tctagaagga cccccccccg ccctccttgg tcctgcagta 706200 gacacatttg ccaaacaccc actcgacact gagctcatgg gaaacaccaa ggttgctgtg 706260 tctgtccctg tggaggttcc agaccagtga ccgagggaga tgctaatgaa tacagaacca 706320 cagacccaag aagggacagc cccacagaag ggcagattta agtagatgat tctgtaacac 706380 cttcacccct cccacctaaa cacaagtttt aaaacacccc agagtaaaga gcaatgaaaa 706440 tttgcaaaag tcatctattt ttatggacaa aataccatag gatatcatta catatgtttc 706500 ttctgatttc tactccttat attgagtgga tgaaattaaa tacccttaat gttctttgaa 706560 aggcagtgtt atgctaagat gtcttttctg ttcttattgg aaatatttca gaatccagtg 706620 gtgacttcat ccacatcacc catattttct aagctcactc acatttgcta gcattgcctg 706680 ctggtatctt cattctaaaa tgaaagatgt ggcttcatac ctttaaagct ttgaaaactt 706740 gaatattcaa aaacataatt ctttaaacaa agaaatgctt gggagtgtgc atgcagcttt 706800 ttaaagatac tttcactcat gggattaaaa tcaaagtgat gagataaatg tgcgatgtag 706860 aagtctgcac ttcatttccg aaagataagc aagaaacctt cagaaacatg aacctgcctg 706920 cgaatggtca ctcttcctgc tacctgagag atttcgttta tgaggcaggt cagttcacgg 706980 ggctactgga cacttttgca caaactcccc agactgcagc ctccgggact ggctggattc 707040 ccacagacac tgagcaggaa gtgactgctg accgacacca catacacgtg cgcacacacc 707100 acacatacat gcaccccaca tacaccacac accacacata ccacacacac acctcacaaa 707160 catcacatac cacaccacac ccacacatat cccacactca ccacacacac cacacctcac 707220 acaccccaca tgcacacaca acacacatac acacacccca catacaccac acataccaca 707280 ccacgcatac cacacacaca caccacacat acaccacata tcacaccaca cacacatccc 707340 tcatatacca cacgccacat gacacacacc cctcatacac atacacaaac tgcatgtaca 707400 tcacccacca catgacacac actccatata caccacatac cacaccacac gtacacaaac 707460 accacataca cctatgaaag gaaaatatct ttttggcccc caaaatcact aaggaaaagt 707520 caagctggaa actgctcagg gccaacctgc ctcccattct attcaaagtc acccctctgc 707580 tcactgagat agatgcatat ttgatggcct cctttggaaa ggctgatcag aaactcagaa 707640 gaacgcaacc cttcccctct cacctacctg tgacctgtaa gtcccctccc cgcttcctgt 707700 cttcttgcct ttgcttcagg ttgtcctgcc ttccagaccg aaccaatata cttcttacct 707760 atattgattg atgtctcacg tctccctaaa atgtataaaa ccaaactgtg ccccgaccac 707820 cctgggcacg tgttgtcagg acctcctgaa gctgtgttgt gggtacgtcc tcaaccttcg 707880 caaaataaac tttctaaatt aactgagacc tgtctcaggt tttcagggtc cacataccac 707940 accacacaca ccccacatac accatgtacc acaccacatg tacacaccac acatacacac 708000 accacacacc acaccacaca tcccacatac tcatgcatac acacaccaca catacataca 708060 cacacacaca acacacacta cacacacact acacacacac cacacataca ccacacacca 708120 taaccccagg cacatctcac atacaccaca caccacacca cacacacccc atatacacca 708180 tgtaccacac cacacataca caccacacac accacactta cacaccacac acaccccaca 708240 tatacatgca cacacaccac acatacaccc cacatacacc acacaccaca ccacacgtac 708300 acacaccaca cataccacac atacacatac cccccataca ctgcacacta tgccacacat 708360 acagcccaca tatactgcac accacataca tacacaccac acacaccaca catacaccac 708420 acaccacacc acacatacac cacatatcac accacacaca ccccccacac acacgtaccc 708480 cacatacacc acacactcac cacacacacc tcacctacac cacataccac accacacaca 708540 ccccgtatat gtcacacacc acacatacac aaaccccaca tacaccacac acactccgca 708600 tacatatgca cacacacaca ccacacacac ccccaataca ccacacacta caccacacat 708660 acacacacac cacaccacgc acaccccaca cgcacccccc acatacacca ctcaccacac 708720 cacacatcac acaacacatg taacacaccc catgctactc acaacatata cctcatacac 708780 acagcacaca catacaccat acacacacac cacgcacaca ggtacacaca caccatgcac 708840 atcgcatacc acaaacacca cacacacccc ccacacattc acacaggctg agaggggcaa 708900 atattgttac taccactgta attagcaata gcccgaatac tttccaaaat acgtctaaga 708960 aagaattctg ttgttaatgt ggtcagatga aataaaactg gttagtatat ttgataggga 709020 aggttaaata aacaatattt tgatgaattt tctgattttt ttttcatggt cagaaagtta 709080 aatcatggtt aaggcctgaa agaaacaatt tatttgagat tgctaggaaa gttgtatcct 709140 ttgaaaagtt accattttcc tctgaatttt tgctaacttc catctcatcc atctttcttc 709200 atggaaaaaa tggtacattc tgaaaggaag caacaattag gtgccaactg gagtgtgtgg 709260 gcagctgagg cttgcttcag aagctattcc cgcacctatt gttttctgcc ttaaaaccct 709320 ctgaggatga ggcaagatat aaatacacaa aactattttg tttaaaacaa aatttttaat 709380 agaaaaaatc tgatttctaa atttatttta tatatttttt taattttatt tcactcatga 709440 cctcaactga acaatacact tcagttaatg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 709500 tgtgtgtgtg tgtgtgtgta ttaaacagcc ctacagaggc atgaaagcta gactgtagaa 709560 actcatgttt aaaaagaaaa agcgttaaaa agaatggcaa actaaacact cagttttgta 709620 tctggctttc ttctttttca ttctttgctt tttatttctt ccatatctgc tagtcaccta 709680 gtatctgtca tcaggaaaat agccttcctt cacagcctat gaggcgttct agcagataga 709740 gccaactgtg gctcaggtag ttttagaaat cttaaaattg ggattttgac tgcctttgtc 709800 ttcatggttc atgataaatt agttaatcaa aataacttga accccccccc caatgttaat 709860 tctaattagt atattaacca ttagcatttt taatcatttt gttttaagtg tttgcttttt 709920 tttttttttt tttttccttg agacagagtc tcgctctgtc gcccaggctg gagtgcagtg 709980 gtgcgatctc gactcactgc aagctccacc tcccaggttc acgccgttct cttgcctcag 710040 cctccccgag tacctgggac tacaggtgcc caccaccacg ccaggctaat tttttgtatt 710100 tttagtagag atggggtttc accgtgttag ccaggatggt ctcgatgtct tgacctcgtg 710160 atccacccgc cttggcctcc cgaagtgctg ggattacagg catgagccac tgcaccgggc 710220 caagtgtttg ctttctttaa gaagatcaga gaggccaggt tgtccttctc cctccccacc 710280 aggctcctct tcctcattct gtctgattca agagttgcat tctgattcaa gtatttgccg 710340 gagggtcaca gctttctcct atattgtgaa atgatcctac tttttctgtg aggtggacac 710400 cctgcactct tgggaaaaaa agaccttcat cagagtctca taaccagcta ccagcaccct 710460 gccctgatca gcccctcccc tcagctgtat ttttattgat tgcgtgtgta tatatctgta 710520 gggaggtacg tgtgtgatct ttgacagtga agtttctaaa tctgaaaaga tcttaatgag 710580 ttctatattt aaagtttgtc cattagcata tgagttttta attagtttgt ttaaagacag 710640 ggtctggctc tatccttcag gctggagtgc agtggcacaa tcacagctca ctgcagcctc 710700 cagttcctgg gctccaccga tcctctcacc ttgagctact tgggaggctg ggaccacagg 710760 catgagccat catgtctggt tacatttggg tttttatcct aatccaaaag acttatgtta 710820 aatatattca ggaaaaggaa tataattgaa tatggaaaga cccgtccttc agagatgaga 710880 atttccaatc catctgggac aaccaagtat tgatattttg actacctggt gaccacacat 710940 gctcacacag tctcctcatt ttcgtaagcc ctccgttgag atttccaaat tgtgaccttt 711000 aacagctggc accctgctgg cctccctaga agacaggagt ccaaaggcct gtctttgggc 711060 catcctcgcc ctgctccctc cccagcaaag ccccagccta cagaactgtc tgcttctggt 711120 gctcccaggc ctttggctcc cactggggcc tggactgtgg gagccacatg gagccccttt 711180 acccctcttc ttgcaactcc tagaaggcac aggggctctc tggcatgtga gggacaggcc 711240 tcagccatcc catgcagtat ttgccatgct cctttaatgc tgtatccgtt ccacattgat 711300 ctttttggtg acaaaaaaaa gatgaacaaa agatgttcca cagtcatcgt aatcacaaaa 711360 tacatggcta ttcatttgtg aacctccatg caatatcctg gacacacaaa atacgtggct 711420 attcatttgt gaacttctgt gcaatatcct ggacacacaa gagaaaagaa aaacaatgag 711480 caggaaggaa aaccaagaca ggcaaaaagc aaaagcccgt ttaatctggc cgacacgacg 711540 gctcgtgggt gcctccattt tcagcccatt ttctgctttt tcccagagcg actgaggaga 711600 gcagctgaga tccgcggcct gtgccctcag ccactgtgct gggctccttg atcctctctg 711660 tccctcgact tccttgtctg taaaatgaat gggttgcaaa agtaattgaa taactctgct 711720 ggttgtataa gttactatct gtacttagaa tagcatagcg ctggcaccta ggcaggcatg 711780 catatcacat ccactcccta tatggaggcc agggagagtg agagggattg acaagcagct 711840 ggattgtcag ttgacgagca ggtctgccaa atcagagctg ttcaacaagg aactccccag 711900 acctgctggt ctcttggggt aaccggcctg ctctgggtac caatgtgtcg ctgacagccc 711960 cttcccctag gggaacagtt ctcaggccct tctcatgctc tgaaggcgac tcatttcaaa 712020 acccatcagc caaacaccaa ggaagtactt agcacaacat tcgtaagttt tctcaaattg 712080 ccgtgtatca tatgctggag ttgagagcgc atagtgttcc atctgtgaat gttattagtt 712140 gatcccactc ctgaaagtga agcattttta gctgacacca agtttctgac acatgggcat 712200 gtcacttcag gattgaagct gagaggagtt cactccaggt aaaaagaggg gttggctgag 712260 ccactcagtt tagctcaggt gtattttttt cttatttaaa tatgttatct tttcagcttt 712320 attaaggtat agttgacaaa taaaaattgc atatatttca gacatgcagc ttgttttgat 712380 gtatgtatcc aatgtgaaat gctcgccaca atcaagcaaa ttaacagcgg gtccaccatc 712440 tcacatagtt gccattttct tcctccaccc ccaaatgata caaagtttca gttatgcaag 712500 atgaataagt tctggagatc taatgtacaa agtggtgact atagttaaag acactgtctt 712560 atagacttga aacttgctga agagggtaga tcagatattt gggatgaagt taggtactta 712620 aaaatacatg tatgttaaag tagagcttgt ttaaaataac aataaaaccc ctcagcttgc 712680 agaagcttcc taatgaatag tcggcagtgg ggctgccaag tgtgcagcgt gtgtgtgtcg 712740 ccctaagtgt gctgctaggg gtgcagggga cattgctcat tagcacctgc tgaagggtga 712800 gtggcagccc tggtgctggc cttgggttga taacacttaa cttggagcga attacttcgt 712860 tttccagacc aacgttctgc cttgtgttct ggagcagttt ggtgtgaatg ttcttttcca 712920 aagggccacg tgacaccatg agctcacagg atgactgtgc acagtccctt tgagaattct 712980 cgtgtccaga tgatggctgg acgggtgatg gcatggcaca gggacagtca gtggggacag 713040 tgcggaaaaa cgagcagaaa tgggctcaga agtgggattt tgttttcttg ttcttgtcct 713100 ccagagctgg gtgagattaa aaacatcacc accacacagc cttcactgga gctggacggg 713160 ctggaaaagt acaccaacta cagcatccag gtgctggcct tcacccgcgc aggagacggg 713220 gtcaggagtg agcagatctt cacccggacc aaagaggatg gtgagagacg ggtgggcggt 713280 gggtcccagc agttgctgga agggctgggt cacagagagc tcacttgcct ttaccctgca 713340 gttcatcagg ctattctcag tgcaaacctt tgctgccctc ccaaaatatc ccagtgcaat 713400 tcagaccatt aacttcctct cttgcctttg cttgatgtgt ctaatccatt gcttcttctt 713460 cctctatatt ttttcttctt tcttttcttt ttttttgttt tttgtttttt ttggccaagt 713520 attattgtaa atagaaactc attttatcct agagctgtaa tacttgtcat acatgttttg 713580 tatcttgtta gaataatttt agtagctatt cagctattag tgtaaactct gattaaatcc 713640 atccttccac ttcttgaaaa ttatgtacag actgaagttc tattattctt tgccagctga 713700 atcactttag aataagtcct taatttgaga acttcatgtt aatttttttt aattcttgca 713760 agaattcatg gtgatttagt aaaaatttaa attgctgctc attttgttct acaacaataa 713820 ttcttgctgt tccttacaat ttggattggg ttgtgactat tacccaaacg tacaaaaacc 713880 atacaacaaa ggttctgtat tattttaagg gaaactctga ggggccttgg ccaagcctgt 713940 ttaaggaaca gataagttct gataaatact accgtggtag tgagaaaagt agcctccacc 714000 ttaataaagg aaggagcaac tgatgtcaaa ttgatgccca catagaacct tcccaaaata 714060 ttccagcaca gaagtataca ttgagatgag acattagcag atctaaatgc tgtgctggat 714120 tgtctctgca acttttgtct tcttgccggg actctgttcc ccaagcagta caggggcggg 714180 aaagctgttg gccattgctg gtcacctcct gtgtatgggc aggtttgatg tctatgctat 714240 ctcccccact actagagtat caaaaatgct gttattccat cccatatctg ctctgatgga 714300 agcaaagaac acctgctcag gggccatgat acgctcttct cttcagcctt tctgcccctg 714360 acaatgactc cctgttattc tgagcctgcc atcttccacg tcactctctg ctctcacctt 714420 ggcaagccag gccttgctcc tccgagcagc cccaggcatc cactctcacc tggtgttttt 714480 gctgcctctg tagcccttct cacattgtaa tgtctacacc caaactaatc ctcatttgct 714540 ttagtttttt tctaaaatgc acaggtagtc cttccaggga atgtgcaggt gtcagccagt 714600 tctgctctaa gaaattggat tatttaggga atctaaggtt caaatgtaat gccattagga 714660 agtcacacat caatagagat atctagaaag ctaagtcctg agtgaaggca gccataagtt 714720 aattttttaa aaatgtaaca gacaaacagc tgtgcaaatg ctggctctgt cacctgctgc 714780 ccgtgggtct ttgggcacct tacctaagtg tctctgaact ggattgtcct cagggacaat 714840 ctgctgtagc catcagactg cacagaacca gtgtatgaga gctgaagtgg tgtctgaaaa 714900 cacctgcttg ccacagagtg ggatgcttcc tgaccctcaa tatttgatta tttgctctcc 714960 actccttcag agtaggggtg aaatactcct ttttacattg ctaggcaata atgcaaatgt 715020 cactggaatt attatttaaa gagcaaattg atcatccaca aaatgttttg catctgcatt 715080 tttggaagaa tgtacagaaa tccaataaga agggaaggct cttcacagat ccttattaac 715140 tcacaatttt agatcaattt ttaattaata ttggagtttt aagaatcatg gagttctgtc 715200 tcaaaacttg accccaaggc ccaaggtcta atttgtcaat caattatgct ttgcttttgt 715260 ctccagtgct gatagtgtat ggagctggga ttgactatcg aaaaccctgc cttgggtacc 715320 ccagttaccc caaggaagat gccatgaatc ccacttttgc tggtggtatg ggacaaggac 715380 tatgcagaac tgagtgtcaa tatttcttta ggataagtct gcattttcaa aaagaagtgg 715440 agtggtggat cgcttgaggc caggagttcg agaccagcct ggccaacatg gtgaaaccct 715500 gtctctacta aaaatgcaaa attagccagg tgtggtggtg ggcacctcta atcccagcta 715560 ctcgggaggc tgaggcagga gaatcacttg aacccaggtg gcagaggctg cagtgagctg 715620 agatcgtgca actgcactcc agcctgggtg acggatcgag actctgtctc aaaaagaaaa 715680 aagaggtgga gtgaagattg ggtggaagaa gagaagaact agaataatat cacttcatct 715740 cccaggttca catgaaaaat tcaataattt agaaacggtg aagaattgtg tcaaccactt 715800 ttgtagactc aatacctaat ataattaggc atttcagcag tttacagaat taaatgctat 715860 tttatttatc tgattggaag aagggacaaa ggacaattca gagaacaaat gcccagtcaa 715920 attgattaca gatcgtattt atacttcaat gagaaagctt tgtaattttg aagtttggat 715980 tacacttaca atttcaatta aattgtgtaa aaatacagat agatttccag taaaataata 716040 attaccaaca tttgctcagt tctttctcaa taagatacta ttttaggctc aggttgaagt 716100 ttcagcgttt atcaacgttc ttgcaagcga agaaagatag ctacattaac agcgagcatc 716160 cgattcagtt gtctatgcca gacacacgtc ctgtaccagt cttcctaatc tagggagcct 716220 ggaggcttaa actgtgttat taggtcactg gtcatactaa aaagagaaac ttaaccctaa 716280 taaaggcaaa attgtacttt tgcaagggat tatttgcaat agaaatattt gtttagagga 716340 caagtctgtg cttgttctct acaggtagtt tctctaccac tatctaaaga ttcttgggct 716400 catagtcata ttcacagttc catggacaca ttctcatgtc tgtggtcata atctcagggc 716460 catggacata gtctcttatc cataactata gtctccggtg catggacata ttctcatgtc 716520 tgtggtcgga gcctcagggc catggatatc atctctcatc cgtaaataga gtctcaggta 716580 catggacata ttctcatgcc tgtagtcaga gtctcagggc catggatatc atcttttatc 716640 cataaatata gactcaggtg catggacata ttttttgggg tctgtgacta ctgctcacag 716700 ttcacgttct ctttccagga ctgctctatc agtgagaact tgtaccccat tattgctgca 716760 gaaacacgaa ggacgacttg gtgatctggc ttttctgttt ttgagcacaa cagcaactaa 716820 acctgacttc taaaaacagt tgtgaaatcc tgatgccatt ttatttgcca atactataat 716880 acgagtcaag ccgtaaggaa agagaacaca aacaaaatgc aatctattaa tcttccaatt 716940 gctgttttca ctctgaaggc aaaagctagt ttcagccttg atccctttac acaagagtaa 717000 actttgcata tgtatcaata gagatagtta agttcaaata tttactgaac acatcactaa 717060 tgcacctaac tctgaaggta catgtgagag ggccagcagc aggtgtaata tgtgatctct 717120 actccctccc caccatcaat tagcaatctc attgggagga gatctgaaag tagagctaag 717180 aggaagcaaa aaaataagct gacatctgga tacctctgaa tcttctgacc acccatactt 717240 tgagccatac atacttgtga aggtgtggat agtgtgtgcc tgtgacgtgt gctggggtga 717300 ctatgtgacc acacctcagt agacctgaaa gggggtagat tgcatgctat gtttgcatag 717360 ccaccagtgg tgctgcccct cagtagacac tgggaagtac tgccaatcca cactgctcaa 717420 gattccagtg ctctatagcc tatggtagtg tgccatgtgc agtggcaggt ataccagcaa 717480 cacgacagac aagatgtcct agaagagatt ctaccatgtg gctttccaca ctccctccac 717540 tgcagtggat cccaaactag gttcttacct caaactaggt gggcctcagc agtgcccagt 717600 ggtaagcaag aggcccagtg ggagactcca ttctctccct gaccccagct tcaagagcca 717660 ccccacttcc acttgtgtta tgtgctgggt ttccacatga tgatttggtt aaaggatcag 717720 tcaaacattt aaagaatgaa cactcttgct ctagtgagag gaaaggccaa aaatactaga 717780 gtcttatgga catgggaaga gaaaagggac atatgtgcat gcttggtggg atgacagctg 717840 tgaatgtgac atgtccctcc aggatcgtag catctgcacg gcacggcatg gctcaggaaa 717900 agccactgaa aagttgtggg ttcagaagga tctggctacc atggtgtacc acatatgtac 717960 atgcatgttt gtgcatgcac aagtcacaca cacacctgcc tgtggctgtt tactaagacc 718020 agaaaaatga tggtgaaaaa aaatgaagct gactgcggtg tctgtgtggg tgtttagtca 718080 gacttttgtc cgatattcat acttcaaaac aaggcaatac tgtttcagaa aaatgattgt 718140 ggtattttta cattaaggta tgttacagga gggcttaccc acttgtattt attttctatg 718200 ctgtggaaca gattgctaca accttaacac gttaaaacaa tacaaatgtc ttatctcatc 718260 gtttctaagg gtcaggcatc caggtctggt tgagctgagt cccctgctga gggtccgaca 718320 gatgaatcac ggtgtgagct gggcctgtgc cctcatctga ggtcaaggtc tcccaggctc 718380 acaggatatg ggatcttttt tttttttttt ttttgtttgg ttatgaggct ggagtcacca 718440 gcttccagag gctgcctgtt actccctgtc acacccccta cagcatggta gcttccttct 718500 tcaggaccaa taggaaagtc tcacatggct tccaatccct ctgacctctt ttgtctctga 718560 cctccatctc ctcttctaag gggcgcatct gattaaaccc agcccaccca ggaaactttc 718620 cttttcatta actgaaagtc aagtgattag aacctcaatg atacctgaac aagcccttca 718680 cctttgccac atggcacaac ctgcccatgg gaggaatctg tccatcatag taacagatgc 718740 cacacccatt caaggggaag gaatcaccca ggcacataca ctagaaggta aggatcttgg 718800 ggacccattg tagaatcctg cctaccacac agacacgaat gaaatcattt ttccactctt 718860 ggaaaatctg tattgaggat ctagtatgtt ccagatactg gcccaggaac taaagatgca 718920 gagaaacagg atgggcatgg tggggtttgc aagctagtgg gggagacaga cgttgataga 718980 tcacccctga gtggactgtg tcaagtgcaa tgatgaagaa gagtctcaac agagacatgg 719040 gagccctgac ctgacctaag ctggtgatca gggaagactt cctggaggaa atgacgtgtg 719100 ctagaacctg agagatgagt aagagttgcc aggaagaagg cagagggtgg gaaaaactcc 719160 agacagaggc atcccaaggc cctggatcat ggcatcccaa gggcccgggg tgggagaagc 719220 aaaccacgtt cagggaactg aaacagagct cagtgttggg gagcaccatc agatcagggg 719280 gagagcccaa ctgctgacct gtcctgtcca tgtggacctc caaagggccc atcaagtgac 719340 agcaggaaga gaattccagg tcctggttct tgcaactgag aagatgatgg ggccatttcc 719400 tgagatgggg caagagaagc acaggtttgg atagaagatg gtgagtgctg ttgtgactat 719460 gtcggtctaa ggtgcccgtg tgaaacatct cagccaattg gacacatgag acacagaagc 719520 atctgcagct cagaagggat gtccaggtgc attggaggaa tgtagaagag aggattctct 719580 gaaggccaca ttctttactg caatcaatta aacttaaatg cagaactcct ctctatgatg 719640 cccaggaatt catgaaaact tcccaagttt gttttgacct tcataagaaa aactcagatt 719700 accaaaatgg aatgtggtca ctaagaatgt ttcaagaaaa tatgtcccag acagacatat 719760 accgtttttt actccatcct atgccatctc tgtcttctgc aactctcagt gtctggtgtt 719820 tgtcattcac cactgagtca caaagtaaag gctagtatca tttagtgaca tataatccaa 719880 ggacataagg atggttatta gagatgatag ctagaactta tttggtgctt actgtacaga 719940 gaacaataaa taaatgattt acatgaatta tctcttataa ttctaacagt aaaaacataa 720000 gccagcacag ttattattgt agatttataa atgagggaac taaagattat tagagaagtt 720060 aatcagcttg tccaggacgt ggaactaagt gctagagccg catgaaacca gcagtgaggc 720120 tccagggccc acacctttaa gctttatgat gttgtccaaa ccagaactaa aatgttaagt 720180 tctagctctg aaaagattag ctcagtcatc cagaaaacct tccaaaatgc cgtgttcttc 720240 aacttatcta tgttgttatt ttattgtaca aagttctagt aaccatacaa ggaaagactg 720300 tgtaagatag atcataaatc catgcaggag gagccaactg cgagtttaga tggtgcagta 720360 aaagtccctt gatcggctgt gacacaggca tgctcacgga aatcatcact taaaacaagg 720420 aatcaccaaa ctttgcagtg gccaggaagt acctgaaatg ttgcatttta acttaaaaca 720480 tataaatatg tatttattcc ctaatcattc tctaatcaca tgacttagga tcacttcttg 720540 aagttttggg tgaaaagatt ggagctctgt gccatctttt actccatgaa ctgcatttaa 720600 tgtgtagcat ctgcattttt caactggtgt ctcaagtaag agcatgtgac catttaccaa 720660 cgatctgttt gcaaattggg acaaatccac atgtcccatt cttctcagtg gtcctgacca 720720 aacatagatc ggccttcttc tttctttcct ttcttctttc cttcttttct tctttctttt 720780 cttttttatc cttctttcct tttgtcttcc cttcttcctt ccctccttcc ttccttcctt 720840 tcttttttct tccctctttc ctttcttcct tccttccctc cttcattcct tttgttcttc 720900 cctccttcat ttctttctct ttttaatttc ttttctaact tacctctaag gaaggctttc 720960 caaagtagtc ccattaactg tcatagaaac agctttctct tgcacttgaa tttcattggt 721020 ttacgtaatt aattaactta cagtactacc catgacacgt acaattgtca caaacaggtt 721080 ggaaacaaat acaactgact cctcttcagc agccattcaa ctggttggtg ctaaactact 721140 tggcctccta aagagaagct gtccagcaag aatgttcact gtggtgaaca ccaaccaggg 721200 gctttatgga aaggactgag agtgttggct aagctggggt gtctactagg attaaaatcc 721260 ccaggaaacg ttcactctgc ccttgttgtt caggaggaac cctggcagct ctgaactagg 721320 ttgtggatgt cttagacatt accctcacct gatagaggtt tgttctcaag ggatttttta 721380 acccaggatc tatcatttat gtgtgttacc ttttctagac cttccactgt tagcaagact 721440 tgccaaaaat ggattaccaa gattttatat tttcaaatgg tgactatgtc caacccaagt 721500 tagttctcac cagagctctt ggttttgtta tgcagactta gaagagtcaa ggtgacgatt 721560 atgagaagca cattcaactc caaaacaatt tactgagcag ttgcattgcc atcaaagcag 721620 taaaagactc acagatttct ccaggggctt gcaagggact tctattggtt tgaatttcaa 721680 tgtctccatc aatgtggttg ccctccatat ggacagtgag gttaatgaga aacaaagcaa 721740 gagctctgat gccttcctca ctggcacctt tgacattttg gcatcttctt gtcttggcca 721800 tctcacccgc cctcacctct tcaacctgga aaataaaaga acaagaggag tgggacatgc 721860 cttcaatctc actcccaaat catgcttagt attgctgcca ccatgttctg ccttcttagc 721920 tggtttacag aggagagttt gtcttacatg gatactgtga atctttgacc caataatccc 721980 tattcatcaa caatatttcc atacctctcc tgagcccaaa gtggtgccat tacaaaatga 722040 ctagggtgag ggagggtggg gtctctgatg gctgaggtag ttcaccctca tgcttctcaa 722100 attcaggatc caaaaggttc atccccagta cattcaaagc caaaaactgc agcagaaatg 722160 agactgatcc agaagttaat tctccagtta tccagaggca ggaagttgcc aggggctgaa 722220 atgggttggg aagactcccc aggacaagag ggactagaac tgactgtatt aggtcctaga 722280 gctacaaagg accacagact ccaacattag gaatttattt gctgtctctg agttctggag 722340 gccagaagtc caaaatcaag gtgtctgcag ggctggttct ctttaagagc tttgagacaa 722400 gcatctgtcc tgggcttctc tccttggctt atagatgccc tcttctccct gtgtcttcac 722460 atcatcttcc ctctatacat gtctgtctct gtgtccaaac tggccctttt tataaggaca 722520 ccagaagtac tggattaggg accaccctaa caaactcatt ttaacttgat tacctctgta 722580 aagaccctac ctccaattac agtgtcattc tgtggtcctg ggggttagga cttcaacata 722640 tgcatttggg gggacacagc ggaacccata acgctcatcc tgaaagagct gaacagtaag 722700 tgcggagtgg ggtcatgttg ggaagcgtgg gtccgcaagc ccaagttgag gccccacctt 722760 gtgactaaac acacggctct tccagttcca ggtcctcccg cgggtgtgaa ggcagcggcg 722820 gcctcagcct ccatggtctt tgtgtcctgg cttccccctc tcaagctgaa cggcatcatc 722880 cgaaagtaca ctgtattctg ctcccacccc tatcccacag taagttggta aataaccaag 722940 tgcctttcaa gcgtctgcca gggacgagct gcaggtgctc gcactggaca gtttcgttcc 723000 tttgtttccc acctacctgg gtctttccag tggttttgtt ttgcccctgc tgtctccaca 723060 tacaaaacaa agtcctcatt tacacctcat ttgaaaatac gctcctgaat catgacaagg 723120 gggacaattg tctggaatta ttgtttattt ggtgagttcc cactaaactg ccagcagcct 723180 gatcaaaatc aaaacccaga ggccttgatt gtgccttaat tgatagtcag tggacaacac 723240 ctattgattt tactgttgga ctcatcatga taagcacttc acgccttccc tccctccctt 723300 ctccctccct ccctccttcc ctccctcctt ccttccctcc caccctatcc ctcccttctt 723360 tccctcctcc atctctcaca gggaaaagaa tagcaggcaa aaccctattg tgctagaaat 723420 gagggacttt aatgaagatc tattaccctt acagttacag cagtcagcct ggttcattgt 723480 gaaggaacta aaagttattt actatttcaa agtgtggttt ttgttatcgt tcatattatt 723540 cctgctgaat aatcattata aagttagact gcttctgaga ccacaccaaa acatatcaaa 723600 aagggaaatt ttaaagaaaa gaaaacatta aaatgaccca ccaaaattga cgatgtcttc 723660 atggaaacat tatgacattt tctgcagcag gtgccatgtc tcttccatct ttgtatctcc 723720 agctcccagc atagaacttg acacatgtag tcattcacta agcgtttgtt gagtgaatat 723780 acacactggt tttgtttcct ttctggtaaa atacacataa cgtaaaactt accctcttga 723840 ccactttgat tattgagttc atcagtatta cataccttca cgttgttgtg aagccatcac 723900 caccatccat ctccagaact ctacaaaacc gaaactctgt ccccattaaa cacgaattcc 723960 ctatcctccc tcccaccagc ccatggcacc caccattcta ctttctgtct ctggatttga 724020 ctcctctagg gacctcatgc atgtggaatg atatagcatt tgtcatttag tgaccagctc 724080 gtttcacttg acatgatatc ctcaaggttc atccatgttg tagcatgcga tggaatctcc 724140 ttccttgtta gggctgaaaa atattcccaa acaaatttat ggattaatct tttaatcaag 724200 gtgatatgtt tgcccaagct cagagtccac aggtgcccct gaggcctggt gtaccccaac 724260 agtgagtgtg tgagagtgtg tgggcttgct tggcccatga agttccgtct gttgctgaaa 724320 aagcaaggtg tgttctctac tgcttatgca ttcatggcag tactctgccc ttgaagtcaa 724380 tatgtaaacg taaatagtca gagttagact ccacaacatt tttctgggct tcttatgtgg 724440 ttttcaatat gctgttaatc ctcacttact gaatcctact atcaaagccc agagatggag 724500 agcagcgtag acactgaaaa aaagctgagc cattgtgccc tcaatgccca gggtggcttc 724560 tgcttttctg cttatcactg acatgtcccg tattcaccaa agagagacaa aaattattgc 724620 tgaaataaag tatactcatt ttccactaga acttgaattg catctgtatt agtattcact 724680 cattcattca ttgatctctt tgctatggga ttcacggttg ctcttttgac tctaacaggc 724740 tagaaagcac ctagcagggt atagaaagac cagcagcttc ctctcgtttt gtcttctcaa 724800 tcatcttatc tttatctctg cactaaaaat ccctacctgg cttacttgaa atgagtcctt 724860 agtgactgat gcttactgag aaagccccta tttgtggatg atacaggctg tatttggctc 724920 tgtcctcctg gcctaagaat tacatacaat agaaaaggaa gaaaaaacat cctatcctga 724980 aaacaaagtc acacaggtgt tgttagatgg ggtagaaacg catttcccca ggatttctcc 725040 tgtctcttca cccacagaac aatgggattt gacctgccca ggatcttaac aacacactct 725100 caaaagggac agtaatgagg gccagcaagg cacggtggct cacgcctgta atcccagcac 725160 tttgggaagc caaggcagga ggatcacttg aggccaggag tttgagacca gcctggccaa 725220 cgtatgaaac tccgcctcta caaaaaatac aaaaattagc caggtgtggt ggtacatgcc 725280 tgtaatctca ggtacttggg aggagctgag gcaggagaaa ctcttgaacc tgggaggtgg 725340 aggttgccgt gagccaaaat gtcaccactg cactccagcc tgggcaacag agcaagactc 725400 tgtctcaaaa aaaaaaaaaa aaaaaaaaaa aagacagtaa tgagagcaaa cccaccagaa 725460 aaaggtggga aataacagct gagattttta tcagggtatc tctgtgttgc cttttgacca 725520 tattaaaaag actagagaca tagaaatatg atgggcaggt gcctgtgttc ttccaggaga 725580 taatacctag aaagtgttac aaggaggtcc cagaacccca gagcatctta attgaagtga 725640 agtgaactaa aaacagttcc ctctccatat ccaccttcct gtctatctat ctcaaccatc 725700 atttaagagc acgagaccta ttttttacat caaatagtat cagtgagagt caagctcaga 725760 gacaattatt tctcttcaga ggtgaatact tgtaaatagt atccattatt ctgttttaaa 725820 tatgaaatga tcaagaaact ttaaagtaca ggaaagaggg tgtttttttg ttttgttttg 725880 ttttcatcag tttctgcaat ttgactttca gtcggtaaac tagatgctgt caagttttcc 725940 aaggcatttg catttctggc tatgtgtgcg aatgaccacc agaggacagt atgagctcta 726000 gatattttcc ttgctcataa atctgaattt ttttttcttt gaaatgattt catagttaaa 726060 tgtagaacat agggggataa atcaggacac aatatgcctt gtaatttggt cccttttata 726120 agagtccctc agctaacctc ctcgctgatg tcattttctc tcaagatccc aaattcatct 726180 ccccttcttg ggaaagaacc ctgttaaaat agacaagctt ttttctctaa tatgtgacat 726240 ataatgtctg ctgataggca tttatttcat ggtgctctct cagtttagct tagaaaaaga 726300 cattagaatt tgaaacttgc atgtggccag atgacaagtt agggtaactg agaatgaatc 726360 tacaaacagg ttgtctaaag atgatgtgga ctgaacatga actttccctc gggggtccaa 726420 cagtgcaatg agatattaaa ctccccaatc agagattcaa actgcaaaat ctcaaaagtc 726480 atttgattca gagcctcatc cacataattt gtggattctg gctattaatt ttaatatata 726540 gtggtttgaa tgatcaaaca atctattata agcaatgaaa atccaaagac gtgagataac 726600 ccttttaagg tcccaggaag aaaacagcca agcttcattt cctccccaac gctcccgtct 726660 acataaaagc agtctgaaaa actttcacaa acagactgct tttactatat acacattaaa 726720 taagcattat gatatagaca ttgtctgttt cacaatgcta atctcatttg cggagcttag 726780 aaatgtaaaa ttaggaagca cagacttctc attaatgaaa actaaaaatc agaaggcata 726840 aaatatctct gagctgtgat tcacattggt tattccagct tcagatgata atgttattca 726900 gttcctgtac atagtaggtg ctcaataaat gttgctgagt taatcagtga gaatacacca 726960 ctactcttct tacccagaag acctgggcaa ttaagttctc cacattgtag cccataactt 727020 agaattaaac aagtcttctg ggaggcaaag taactcacca ggtccagaca gcttcccacc 727080 ccaggcaaca ggtgtgtgtt tgcctcccaa tcagccacag actgcatcaa ataaagccat 727140 agtcaggctg agagcgaaag gggacttccg agaaccagaa atgtgcagga atctcaagga 727200 gtggaaaagt ggtataacgt ggaatctgga aagcagcatc taacgtgctc atctgtatct 727260 acaatgatac tcatcgctgt gttcattctt cctctctcac acggaacacg gacctcctgg 727320 ctgtattaaa acgtcgttcc tccctcccag taccctccct atttcatgtc actgtagcat 727380 atagtgacgc tactagatag caatttgctt ttaaaatcct ccttctctta gcttccatta 727440 tcatgttttt tattctttgt tgcttcttgt ccctctgctt cccaccctta aatgtaggca 727500 tttcccaata ttcttccttt atctcttaat attcttcact atctctgtgg atcattgaat 727560 ctgttcttat aatgtaacta tcatctgaaa ttaaagagtt cgcatttttt atctctatcc 727620 tgacaatctt agagaaccgt cagtcctata tttccagctt accaccatct gcgtactcag 727680 gaagacctct ccagtacttc gcattcaatg tgcccacaaa cacatttata cttgtgtctc 727740 cctcttttcc tgtgttctga tttagcttac gatctaacaa aatctgctgc cttctgacca 727800 gaagccttca agctacctat agttcctctc ctaatcattt attcattttt accacaaata 727860 aacatagagc actactctta caccaagctc tgagccaggt tctgaatcac atcaatcaag 727920 agatgctgag ttagggggca tcacaaacag gcctgaaacc tcagtgattt acaacaacca 727980 tacaacaacc aatggtttta tttttctttc acgatcatgc tcattgtgag tatgtggtag 728040 tacatgccat gctatcttca ctccaggaag gacccaggca ggtttcatga caaagagaaa 728100 gaaatctctg aggcgctgac ataggcaggt aaacgctcca agcacaaatc acgagccaga 728160 atctgtcata agattctggt ccatgtctta accacaaagg gaccatgacg tacgctccaa 728220 acccataccc agaagttcca gggaaggcag gaaacactag acaatgtcac ccttctgtgt 728280 gatgtgacag aggacacagc aatgatgtgc acagcacagt gcaggagcgc ggactgggtg 728340 tcactcaaac atacggccag agatggttgc ttggaacaca tagctagccc tggcttgcag 728400 gaagagaaga attttacctg atgaatcaga ggcaggaaag ggtaatatga tcagaggaaa 728460 taaatgagca aagtgacatc atgtcacaag agctctctgc aatgtctttt ttgttgtttg 728520 tttgttttga gacggagttt cactctgtcg ccaggctata gtgcagtggc gcaatctcgg 728580 ctcactgcaa cctccacctc ccaggttcaa acgattctcc tgcctcagcc tcctgagtag 728640 ctgggattac aggcacccgc caccccacca ggctaatttc tgtggtttta gtggagatgg 728700 ggttttcacc atgttggcca ggctgctctc aaacttctga cctcaagtga tcggcctgcc 728760 tcggcctccc aatgcaatgt cttcttaatc tccttccttt cacacccaat gccattgcct 728820 tgcttcaggt cctcccctgg agaatcaaaa ccaagtcaga agccttccca ctgccaggct 728880 caactcccag tctgttgtcc acatccctgt cacaattcct ttttccaatt ctgaatctga 728940 gcatgttatt tcctagtgca aatttattgg atgacttcgc agtttttacc taaagacatt 729000 caaaattctc aatatgacct agatagattt ccacaatcca gctgcatctc ctgtctagtt 729060 tcatattcta aaaaccttct tccatccaat atctaagtaa taccatgtct catatgtgtc 729120 tgcatttgtg cacgtgtgtg tatgtgtgtg tgtgtgtgtg tgtgtacacg tattgggttt 729180 ttcttacctt ttccattcca tcctctttgg taaaaatgtt tattgtttaa agctcaactt 729240 aaatgctgta tttttatttc accacttttt atcactggct acacattagg caccgagtgc 729300 caaaagcttt atacctatgg tttttgaact tgccctatgg tgacccacga tagaaaatat 729360 aagttataat cacgccacga aagtactcgc acaccacaaa cttacattta ctacacgtga 729420 tgccctccga tattttctgt tccatttgac tttttttcta ttctatttca ttttgttttt 729480 aaagtgattg tcatgttcca ttaaattcct cctatgactc acatttttaa aaatactgtt 729540 ttgcatcagt taattctggt gactacctta cgcaggaggt gttatgattg ttatcttcac 729600 tcagtgatac tgaaatgaag actctgcaat ctggccaggg tcacgcaggt tagcaaagga 729660 agatgggatc tgcaacccac agcgggctga gctctttgtc ctcatgctta cctgccttcc 729720 ctgggatccc agttccatcc tgccccagta ctcccagcac tgactttcaa cctcactttg 729780 acataaccac aatctcttgc gttattgtta gacatgggca tagactggca aacctggtat 729840 tgtgctgaaa tagtggatgt tcctcaaatg tgtgttgaat taaattttat agatgatgac 729900 tgtgagtcat ctaaaagagg ttaaattgtg taatgaagct gtagcttaat aaggcaagaa 729960 attgtgttat gtactttggg atgctttgta tcccagaagg atttggatca agtgcctgtg 730020 cttttaaatc acttacatag aaatcattct tccatcattt tatttaaatg acttaaggat 730080 gaatcttttt tttttttttt tttttttttt ttgagacaga gtctcactct gtcacccagg 730140 ctggagtgca atggtgcgat ctcggctcac tgcaaactct gcctcccggg ttcatgctat 730200 tctcctgcct cggcctccca agtagctggg actacaggcg cccgccacca tgcctggcta 730260 atgttttgta tttttagtag agatgaggtt tcactgtgtt agccaggatg gtctcgatct 730320 cctgacctca tgatccgccc gcctcggcct cccaaagtgc tgggattaca ggcgtgagcc 730380 accgcgcccg gtcgaatctc tctctttttt tttttttaat aatggaaaat ctgaaaatta 730440 tggagatacc acaagttggc ctaaaaatag acaattgtat tccatttacg cacatgtaat 730500 gaatcatata catgagacct ttgtgcagtg cttctacatg gcaggcagat gctaggctct 730560 ctatgttctt ggatcaacca aggattactg tagccccagc atcctgtcat ggaatcatac 730620 ggctggaaaa aacctcgaag ggtttctttg aggcaaggct acatctaaat atcccagaca 730680 tgtgaaaatc aattctggtt ttataaaatt tcttgggaag tctattcctg aagctttctt 730740 ggaaatatct ttttatttca cggctagttc taatggaatg cagttcgtta ttttttcact 730800 tttaagttca ggggtaacgt gcagatttct tatataggta aacttgtgtc acaaaagttt 730860 gttttacaga ttatttcatc acccaagtat taatcctaat acccattagt agtttttcct 730920 gatcctcccc ctcctctcac cctccaccct ctgaaaggtg tgtgttgttg ttgtgttgtg 730980 tgttgttccc ctctatgtgt gtgtatgttc tcataattta gctaccacat acaagtgaga 731040 acatgtggta tttgtttttc tatttccatg ttagtttgct aagaataatg gcatccagct 731100 ccatccatct ctgcaaagga catgatcttg ttctttttca tggctgcata gtattctatg 731160 gtgtatattt atcacatttt ctttatctag tctatcattg atgggcattt agattgattt 731220 cacatctttg ctattgtgaa tagagctgca atgaatatat gtgtgcatgt gtctttataa 731280 cataatgatt tctattcctt tgggtatata cccagtaatg ggattgccag gtcaaatggt 731340 atttctgtca ttaggtcttt gaggagttgc cacactgtct tccacaatgc ctgaactaat 731400 ttatactccc atcaacagtg tatgagcatc cctttttctc cacaacctca ccagcatctg 731460 ttattttttg gctttctaat aatagtcatt ctgcctggtg tgagatgata tctcatcgtg 731520 gttttgattt gcatttcttt ttttttatta ttatactgta agttttaggg tacatgtgca 731580 caacgtgcag gtttgttaca tatgtataca tgtgccatgt tggtgtgctg cacccattaa 731640 ctagtcattt aacattaggt atatctccta atgctattcc tcccccgtcc ccgcacccca 731700 caacaggctc cagtgtgtga tgttcccctt cctgtgtcca tgtgttctca ttgttcaatt 731760 cccacctatg agtgagaact tgcggcgttt ggttttttct ccttgcgata gtttgctcag 731820 aatgatggtt tccagcttct tccatgtccc tacaaaggac atgaactcat ccttttttat 731880 ggctgcatag tgttccgtgg tgtatatgtg ccacattttc ttaatccagt ctatcattgc 731940 tggacattta ggttggttcc aagtctttgc tattgtgaat agtgccacag taaacatacg 732000 tgtgcatgtg tctttatagc agcatgtttt ataatccttt gggtatatac ccagtaatag 732060 gatggctggg tcaaatggta tttctagttc tagatcccca aggaatcgcc acactgactt 732120 ccacaatggt tgaactagtt tacagtccca ccaacagtgt aaaagtgttc ctatttctcc 732180 acatcctctc caacacctgt tgtttcctga ctttttaatg atagccattc taactggtgt 732240 gagatggtat ctcattgtgg ttttgatttg catttctcta acagccagtg atgatgagca 732300 ttttgtcatg tgtcttttgg ctgcataaat gtcttctttt gagaagtgtc tgttcgtatc 732360 cttcacccac tttttgatgg ggttgtttgt ttttttcttg taaatttgtt tgagttcatt 732420 gtagattctg gatattagcc ctttgtcaga tgagtagatt gcaaaaattt tctcccattc 732480 tgtaggttgc ctgttcacgc tgatggtagt ctcttttgct gtgcagaagc tctttagttt 732540 aattagatcc catttgtcaa ttttggcttt tgttgccatt gcttttggtg ttttagacat 732600 gaagtccttg cccatgccta tgtcctgaat ggtattgcct aggttttctt ctagggtttt 732660 tatggtttta gatctaacat ttaagtcttt aatccatctt gaattaattt ttgtataagg 732720 tgtaaggaag ggatccagtt tcagctttct acatatggct agccagtttt cccagcacca 732780 tatattaaat agggaatcct ttccccattg cttgtttttc tcaggtttgt caaagatcag 732840 atagttgtag atatggagca ttatttctga gggctctgtt ctgttccatt ggtctatatc 732900 tctgttttgg taccagtacc atgctgtttt ggttactgta gccttgtagt atagtttgaa 732960 gtcaggtagc gtgatgcctc cagctttgtt cttttggctt aggattgact tggcgatgcg 733020 ggctcttttt tggttccata tgaactttaa agtagttttt tccaattcta tgaagaaagt 733080 cattggtagc ttgatgggga tggcattgaa tctataaatt accttgggca gtatggccat 733140 tttcacaata ttgattcttc ctacccatga gcatggaatg ttcttccatt tgtttgtatc 733200 ctcttttatt tcgttgagca gtggtttgta gttctccttg aagaggtcct tcacatccct 733260 tgtaagttgg attcctaggt attttattct ctttgaagca gttgtaaatg ggagttcagt 733320 catgatttgg ctctctgttt gtctgttatt ggtatataag aatgcttgtg atttttgcac 733380 attgattttg tatcctgaga ctttgctgaa attgcttatc agcttaagga gattttgggc 733440 tgagacgatg gggttttcta gatatacaat catgtcatct gcaaacaggg acaatttgac 733500 ttcctctttt cctacttgaa taccctttat ttccttctcc tgcctgaatg ccctggccag 733560 aacttccaac actatgttga ataggagtgg tgagagaggg catccctgtc ttgtgccagt 733620 tttcaaggga atgcttccag tttttgccca ttcagtatga tattggctgt gggtttgtca 733680 tagatagttc ttattatttt gagatacgtc ccatcaatac ctaatttatt gagagttttt 733740 agcatgaagg gttgttgaat tttgtcaaag gccttttctg catctattga gataatcatg 733800 tggtttttgt ctttggttct gtttatatgc tggattacgt ttattgattt gcgtatgctg 733860 aaccagcctt gcatcccagg gatgaagccc acttgatcat ggtggataag ctttttgaag 733920 tgcttattcg gtttgccagt attttactga ggatttttgc atcgatgttc atcagggata 733980 taggtctaaa attccctttt tttgttgtgt ctctgccagg ctttggtatc aggatgatgc 734040 tggcctcata aaatgagtta gggaggattt cctctttttc tattgattgg aatagtttca 734100 gaaggaatgg taccagctcc tccttgtacc tctggtagaa tttggctgtg aatccatctg 734160 gtcctggact ttttttggtt ggtaagctat taattattac ctcaatttca gagcctctta 734220 ttggtctatt cagagattca acttctttct ggtttagtct tgggagggtg tatttgtcaa 734280 ggaattttac catttcttct agattttcta gtttatttgc atagaggtgt gtatagtatt 734340 ctctgatggt agtttgtatt tctgtgggat tggtggtgat atccccttta tcatttgtat 734400 tgggtgtatt tgattcttct ctcttttctt ctttattagt cttgctagcg gtctatcaat 734460 tttgttgatc ttttcaaaaa accacctcct ggattcattg attttttcaa gggttttttg 734520 tttctctatt tcattcagtt ctgctctgat cttagctatt tcttgccttc tgctagcttt 734580 tgaatgtgtt tgctcttgct tctctagttc ttttaattgt gatgttaggg tgtcaatttt 734640 agatctttcc tgctttctct tgtgggcatt tagtgctata aatttccttc tacatactgt 734700 cttaaatgtg tcccagagat tctggtatgt tgtgtctttg ttctcattgg tttcaaggaa 734760 catctttatt tctgccttca tttcgttatg tacccagtag tcattcagga gcaggttgtt 734820 cagtttccat gtagttaagc gattttgagt gagattctta atcctgagtt ctagtttgat 734880 tgacctgtgg tctgagagac agtttgttat aatttctgtt cttttacatt tgctgaggag 734940 agctttactt ccaagtatgt ggtcaatttt ggaatacgtg tggtgtggtg ctgaaaaaaa 735000 tgtgtattct gttgatttgg ggtggagagt tctgtagatg tctattaggt ccgcttggtg 735060 cagagctgag ttcacttcct ggatatcctt gttaactttc tgtctcgttg atctgtctaa 735120 tgttgacagt agggtgttaa agtctcccat tattattgtg tgggagtcta agtctctttg 735180 taggtctcta aggacttgct ttatgaatct gagtgctcct gtattgggtg catatatatt 735240 taggatagtt agctcttctt gttgaattga tccctttacc attatgtaat ggccttcttt 735300 gtctcttttg atctttgttg gtttcaagtc tgttttatca gagactggga ttgcaacccc 735360 tgcctttttt tgttttctat ttgcttggta gatcttcctc caacccttta ttttgagcct 735420 atatgtgtct ctgcatgtga gatgggtttc ctgaatacag cacactgatg ggtcttgact 735480 ctttatccaa tttgccagtc agtgtctttt aattggagca tttagtccat ttacatgtaa 735540 agttaatatt gttatgtgtg aatttgatcc tgtcatcatg atgttagctg gttattttgc 735600 tcgttagttg atgcagtttc ttcctagcct cgacagtctt tacaatttgg catgtttttg 735660 cagtgactgg tactggttgt tcctttccat gtttagtgct tcctttagga gctcttttag 735720 ggccggcctg gtggtgacaa aatctctcag catttgcttg tctgtaaagt attttatttc 735780 tccttcactt atgaagctta gtttggctgg atatgaaatt ctgggttgaa aattcttttc 735840 tttaagaatg ttgaatattg gcccccactc tcttctggct tgtagagttt ctgctgagag 735900 atcagctctt agtctgatag gctttccttt gtgggtaacc caacctttct ctctggctgc 735960 ccttaacatt ttttccttca tttcaacttt ggtgaatctg acaattatgt gtcttggagt 736020 tgctcttctc aaggagtatc tttatggtgt tctctgtatt tcctgaattt gaatgttggc 736080 ctgccttgct agattgggga aattctcctg gataatatcc tgcagagtgt tttccaactt 736140 ggttccattc tctctgtcac tttcaggcac accaatcaga tgtagatttg gtcttttcac 736200 atagtcccat atttcttgga ggctttgttc atttcttttt attctttttt ctctaaactt 736260 ctcttctcac ttcatttcat tcatttgatc ttccatcact gatacccttt cttccagttg 736320 attgaatcag ctactgaggc ttgtgcattc gtcacgtagt tctcatgctg tggttttcag 736380 ctccatcagg tcctttaagg acttctctgc attggttatt ctagttagcc attcgtctaa 736440 tttttttcaa ggtttttaac ttctttgcca tgggttcaaa cttcctcctt tagctctgag 736500 tcgtttgatc atctgaagcc ttcttctctc aactcatcaa aatcatcttc catccagctt 736560 tgttctgttg ctggtgagga gctacgttcc tttggaggag gagaggcatt ctgattttta 736620 gagtttccag ttcttctgct ctgttttttc cccatctttg tggttttatc tacctttggt 736680 ctttgatgat ggtgacgtac agatggggtt ttggtgtgga tgtcctttct gtttgttagt 736740 tttccttctg acagtcagga ccctcaggtg aaggtctgtt ggagtttgct ggaggtcctc 736800 tccagaccct gtttgcctgg gtatcagcag cggaggctgc agaacagtgg atattggtga 736860 acagcaaatg ttgctgcctg atctttcctg tggaaatttt gtctcagagg agtacctggc 736920 cgtgtgaggt gtcagtctgc cccactggtg ggtgcctccc agttaggcta ctcgggggtc 736980 agggacccac ttgaggaggc agtctgtctg ttctcagatc tccagctgca tgctagggga 737040 accactactc tcttcaaagc tgtcagacag tgacatttaa gtgttcagag gtttctgctg 737100 ccttttgttt ggctatgccc tgcccccaga ggtggagtct acagaggcag gcaggcctcc 737160 ttgagctgcg gtgggctcca cccagtttga gcttcccggc cactttgttt acctactcaa 737220 gcctccgcaa tggtgggcgc ccctccccca gcttcactgc caccttgcag tttgatctca 737280 gactgctgtg ctagcaatga gtgaggctct gtgggcatag gaccctccaa gcaaggcaca 737340 ggatataatc tcctggtgtg ccgtttgcta agaccatcgg aaaagtgcag tattagggtg 737400 ggagtgaccc gattttccag gtgccgtctg tcaccccttt ctttaactag gaaagggaat 737460 cccctgaacc cttgtgcttc ctgggtgagg cgatgcctcg ccctgctttg cctcatgctc 737520 ggtgcgctgc acccgctgtc ctgcgtccac tgtccgacac tccccagtga gatgaacccg 737580 gtacctcagt tggaaatgca gaaatcaccc atcttctgcg tcgctcacac tgggagctgt 737640 agactggagc tgttcctatt ccgccatctt ggctccacac cactgatttg catttctcta 737700 atgatcagtg atgttgagct tttcctatgc ttgttggctg catgtaggtt ctcttttgaa 737760 aagtgtctat tcatgtcctc tgcccacgtt ttatcggatt gtttattttt ttcttgtaaa 737820 tttgtttacg tttcttataa aggctgaata ttagaccttt gtcagatgca tagtttgcaa 737880 aaattttctc ccattctgtc agctgtttac tctgttgata atttcttttg ctgcacagaa 737940 gctctttcat ttacttgatc ccatttgtcc atttttgttg ttgttgcgaa ttgcttttgg 738000 tgtcttcatc atgaaatctt tgcccatgcc tatgtcctga atagtattgc ctaggctgtc 738060 ttccagagtg tttttagctt taggttttac atttacattt tttaatccat cttgagttga 738120 tttttgtata tcgtgtaagg aagggagcca gcttcaatct tctgcatatg gctagctagt 738180 tatcccagca ccatttattg aatagggagt cctttcccca ttgcttgttt ttgtcaggtt 738240 tgttgaagat tagatagttg tagatgtgca gtcttatttc tgggttcttt attctgttcc 738300 attggtctat gtgtctgttc ttgtaccaga accatgctgt tttggttact gtagccctgt 738360 agtatagttt gaagtccagt agcatgatgc ttctagcttt gttctttttg cttaggattg 738420 ccttggctgt ttgggctctt tttggttcca actgaatttt taaaatagtt ttttctagtt 738480 ctgtgaagaa tcttaatggt agtttaatga gaatagcatg aatctataag ttgcgtgggt 738540 agtatagcca ttttcagata ttgattcttc ctattcatga gcatgaaatg tttttccatt 738600 tgtttgtgtc atctctgatt tctttgagca gtagtttgta gttctccttg tagggatctc 738660 tcaccatcct agttagcttc attccaaggt actttattct ttttgtggca gttgtgaatg 738720 ggagtttatt cctgatttgg ctctcagctt gactgttgtt agaggatagg aatgctagtg 738780 attttcgcac tatcctgaga ctttactgaa gttgtttatc agcttaagaa gcttttgggc 738840 tgagatgatg gcattttcta gatatggaat catgccatct acaaataggg atagtttgac 738900 ttcctctctt cctgtttgaa tgccttttat ttctttctct tgcctgattg ccctggccag 738960 aacttccaat actgtgttga gtaggagtgg tgagagaggg catccttgtc ttgtgccagt 739020 tttcaagggg aatacttcca gcttttgccc attcagtatg atgttggctg tgggtttgtc 739080 atatatgggt cataatactt tgaggtgtgt tccttcaata actagtttat tgagagtttt 739140 taacatgaat ggatgttgga ttttaccaaa agccttttct gcatctattt gagataatca 739200 cattggctca aaataaaggg atggaggaaa atccagtaag caaatcaaaa acagaaaaaa 739260 gcaggggttg caatcctagt ttctgacaaa acagacttta aaccaacaaa gaacaaaaaa 739320 gacaaagatc taactgtcct aagtttacat catcctatat tttacataat ggtaaagggt 739380 tcaattcaag aagatctaac tatcctaaat atatatacat ccaacacggg agcacccagg 739440 ttcataaagc aagttcttag agaccatcaa agagacttag actcccaccc aataacagtg 739500 ggagacttta acaccccact gacaatatta gacagatcat tgagacaaaa aattaacaaa 739560 gatattcagg acctgagctc aggtcctgaa ttagatggat ttgataaata tctacagaac 739620 tcaaatggat ctgaaagata tttacagaac tctccacccc caaacaacag aatatacatt 739680 cttctcattg ctacatgaca cttactgtaa aattgatcat attaatcaga agtaaaacac 739740 tcctcagcaa atgcaaaaga actgaagtcg taacagtctc tcagaccaca gcacaatcat 739800 attcaaaatc aatactaaga aattcactta aaactataca aattacatgg aaattgaatg 739860 acctgctcct gaatgacttt gggggtaaat aatgaaatta agacagaaat caagaagttc 739920 tttgaaacta ataagaacaa agatacaatg taccagaatc tctgagacac tgctaaggca 739980 gtgttaagag agaaatttat agtactaaat gcccacgtca aaaagttaga aaggtctcaa 740040 gttaacaacc taacatcaca gctagaagaa ctagagaatc aagaacaaac aaatcccaaa 740100 gctagcaaaa gacaagaaat aatcaaaatc agagctgaac agaaggagat agagacatga 740160 aaaaccattc aatggatcaa caaatccagg agctagtttt ttgaaaaaaa aaataaaata 740220 gatagaccac tagctaggat aataaagaaa aaaagtgaca agattcaaac aagtacaatc 740280 agaataaata agtgggatgt taccactggc cccacagaaa tacaaacaac catcagagaa 740340 tattatgaac acctctatgc acataaacta gaaaacctag aagaaatgga taaattcctg 740400 aacacataca ctctcccaag actgaaatag gaagaaattg aatccccgaa cataccaata 740460 atgagttctg aagttgaggc aggaataagt agcctaccaa atgaaaaaag cccaagatta 740520 gatggattca tggctgaatt ctacaagata tacaaagaag agctggtacc attcctattg 740580 aaactattcc aaaaaatcta ggagggggga ctccttccta actcgttcta tgaggccagc 740640 atcatcctga tacccaaatc tggcagagat atgacaaaaa agaaaacttc aggagaatat 740700 ccttgatgaa catcaatgca gaaatctcaa caaaatactg aaaaactgaa tccagcaata 740760 catcaaaaag cttattgata tagtttggct gtgtctccac tcaaatctct tcttgaattg 740820 tacctcacat tttctccatg tgtcatggga aagacccggt ggaaggtaat tgaatcatgg 740880 gggcggattt tcctgtgctg ttctcatgat agtgaataag tctcatgagt tctgatggtt 740940 ttataaagag cagttcccct gcacaccctc tcttgtctgc caccatgtaa aacatgcctt 741000 tgctcctcct tcgccttctg ccatgatttt aaagcctccc cagccatgtg gaactgtgag 741060 tccattaaac ttctttttct ttataaatta cacagtctct ggtatttctt catagcagta 741120 taaaaatggg ctaatacact tatccaccat gatcaagtag gctttattcc caggatgcaa 741180 ggttggttca acatactcaa tcaataaatg tgattcatca cataaacaga agtaaagaca 741240 aaaactacat gattatctca atagatatgg aatgtggttc taaatcttct cagttttttg 741300 tgtgcaattt ttgcctattt atttgacttc tattctttaa gaaagtggaa gggaagtcga 741360 tgttgttttt tataagttta tcatttaata gtggtctttt ttccctgtta tcctattcac 741420 agtgtctgtt ctcacactgc taataaagac atactcaaga ttgagtgact tacaaaggaa 741480 agaggtttaa ttgacttaca gttcagcatg gctggggagg ccttaggaaa cttacaatca 741540 tggtggaagg ggacacaaac atgtccttct tcacgtggca gcagcaagag gaagtgcaga 741600 accaaggcgg gaaatgcccc ttataaagcc aggtctcatg agaactcact cactgtcaca 741660 agaacagcat gagggtaacc acacccatga ttcagttacc tcccacgggg tccctcccac 741720 ggcacatggg gattgtggga actacaattc aagatgagat ttgggtgggg acacagccaa 741780 cccatatcac acagtgaaca agccaataac tactcaatct ttctgttgaa gctatatttc 741840 agttttcttc tcatattgtt ctcagtggtt gtttgtccac taggcattat gtgaaatcat 741900 tcaattgcta taactggtaa aatgcagatg gcctatactc aaggtagaaa tcttggcctt 741960 taaaattctg agcccaatca tgtaatttat agagcaaaga aaacttaagc atatactccc 742020 ctaaaatttt catacagaaa gaggccctgg aaatctcttt tgaagctcag tctcataaga 742080 ctgcctgcct gatttgtcag ataacctgtc actaagcatt ctagctttga ggtagcattc 742140 attcagacta ggtagcttag tgtatgccac cctgaatgta cttccccatt gctgcgtaga 742200 gctttctgat tatccacagg ctaaaatgcc tttaaaaaac ttgactttat tttttaagca 742260 gttttaggtt cacagaaaaa ttgagaagaa ggtacagaga ttttccaaat gcccctgccc 742320 ctactgcaca gcctccccca ctatcgacat cccccaataa agtggtgcat ttgtaacaat 742380 ggtggaacct acattgacac atcattatta gccagtgttc atagtttatg taagacttac 742440 tcttggggtt gtacatttta taggtttgga caaatgtttg atgacatgga tccaccatta 742500 tagcatcatg cagaagtttc actgccctga aaaccctctg tgctcctcct attcatccca 742560 ccctcttaac ctctgatctt tttactgtct ccaaagtttt gctaaaatgc cctttttatc 742620 aattagcttt tggagctttt ggaagattgc agctttgaaa acatcttatc tttttgactt 742680 ggcctgacac agacatattg tactatttaa ggaaataaat tggctttaaa tcatttttca 742740 attaacacta gtggaaagag ctattttttt caattttgta aattctgcat atattatttt 742800 tattactaag aattgtgttt ctcattaatt tcttgtatgt gagaaactat atgataacaa 742860 attagttttt ttgtacagaa tttgttgaat aggtgacagc aatcaagtta aattaataat 742920 gtaactttga cagatagata attttcatgg caggtggtat gacaatgaaa aggggatgag 742980 gaaaaattgt agcaaaggga gattatatcg gttggaaaga gcctgttaac ataagtatct 743040 gtaatgccac ctgggctaat tggatggtgc ttctaattct aaacaattac atcaagaaac 743100 tagtttttct catgccttct ctggatatca actttaatat agttgcaaaa cattatagca 743160 ataactttta tatttggaag gccaaaaata aaatatttta tatttgaaag gctttttaaa 743220 agtagccaat agtctatgta tataattata tatatagtct acatatagtc atatatatag 743280 acatatatat aatggtatct atagtcatat atatatatat ggtcatatat aaaatatttt 743340 atatttgaaa ggctttttaa aagtagccaa tagtctatgt atatagttat atacatagtc 743400 tatatatagt catatatata gtcatatatg taatggtatc tacagtaatc tcagtgaaag 743460 gcagaggaaa ctaccagaat tgcctggctg ttatcccatt tctaccaatg ttggcctctc 743520 aacctatgcc tttaggaaga tctttctgcc atgacatctt cttttataga tgggaactgt 743580 gaaataaaat ggaaattaga tcaaaatata ttatacataa gaattttaaa aatcttaaat 743640 taatgcagtg aactgctaat tcttaatgga atccaggcca tttctttgcc actaaacaag 743700 aagatgttaa gcattctaaa agttccctta ccctataatt aaaagagcta tcaattttgt 743760 ttattgcttg ggggagtttt tttttcactg ctgtggacat tctatctatg aaatcacagc 743820 cttcaagttt ttttaattgc atgttaacaa ttagctatca gagcttttta aaacatcaca 743880 tttccttata gaattagttt ttcattaaaa agttaattga aatttttaaa agtagaattc 743940 cttttatatc agacaggctg aatagtttga catgaacagc ctatggcttt gtagtcattt 744000 tatcctcatt atttcctatc gtactcaaat catttctagg tcattactaa actcacctag 744060 tacaacaaga atttcttcag tgtattccag ttactggtca ttgagtccca gctctaagca 744120 atgctctgaa ccaggttccc tgcagagtga gtagagggat gggtgagtaa aaggagtaga 744180 gggatgggtc ggggagcctg acccctgggg agatgcagta agcacatgca agaccataac 744240 ccacagtgga ataaaggcaa aggctatgaa agacaaaggg cagacttagc ccctgattga 744300 gaggactaga gaaggctctg caaggtctta caagtgcagc tacaagctaa gtaatgtgag 744360 gggttcggaa atgaatttgg caattattgg gtaaacgtct agttttatag acatgaccaa 744420 agagtgttta aagtgcctca ctgtggctaa ttatatctta tttactggtc aaaagcatct 744480 tacacatgaa aagaaaaata ttatatcaac accacaaggc aacaataatt gtggaatgaa 744540 ggcaggtcta gaagacgctg ttcccaggct ttccatgagt tgaccctgaa gcactaggag 744600 aaaactaact tcctcacaac ccttacactc ttttgactgg aagagtaaac tgtgcacatt 744660 tagttcctta ggaacccacg actctaccca gcagacctaa agcagtaaca tacaaagaca 744720 aaacgcttga aatgtgaacg ctctggcttg ggtgtcacaa gatttatccc atttactgta 744780 ttttccactc tggatacggc tttggggagg caaacatgtc agaagtcttg taaaaccttg 744840 ctataaatat tttttaaaac aaatatatga agtttccatt tattttttag gcatcttata 744900 aatattcatc catgtcttca actatgacag ggttggtttt agagaaaggt tcaaacgagt 744960 ttatatctaa attttagtag gaattggtca gacttctatg gtgcctcatt ttaaattaat 745020 ctgtttgcca agctgtggtc acttcttgct ccccgggggc aggaacttgc cttataatct 745080 acacactgca actgaactca gtaaatgacc attaattgaa actcagtaat tatttacaag 745140 cccttcctat tacgaggcat gaagctaaga acttttgcct agattttctt cccacagccc 745200 aaaggagaga acgatagtcc aacaagcttc tatgtctggc tcatggggtc ctataactct 745260 cgccaacatc ccttatccac agacctccat actttgaagg cagcagtgtc tgcctggacc 745320 cccccccacc acctcccaca gtaaaaacca tgaccagccc actgtaagaa tagtatttga 745380 gatggttcat tacataagca acatgcatat tttacatttt atgtgtgtgt cctcagacca 745440 aatacccaaa tcttccccta agaacactgt ggattgcccc tgttacatga catcggtaga 745500 gcaggattcc ccaacccccg ggctacggac taatactagg gacctatact gcatgcttct 745560 tatgggaatc caactaatgc ctgatgatct gaggtgaaac agtttcatcc caagaccatc 745620 ccatcctacc acgtccatcc atctgtgaaa aaaaaaactg tcttccacga aatctgtccc 745680 tgatgccaaa aaggctgggg accgctgagc cagagagagc cctgttcttc tcatgccacc 745740 atgttatctg gtggaccaag aaatcagtaa cttggcagcc acttagagcc tttcaattga 745800 gaagtgatta attaataata aatgttggct tgcttctcaa cttggataga gcctacatgt 745860 ttaaacacat tttagatgag aaataacagg ctttttcctc agctagccaa gaggaatata 745920 tgacagatgc aaaataattg gcaaccccag tccacaaatg tcccatccac ttcctcaagc 745980 tgggcataga cagagcagga ttaaaaataa gccatggaag ggaatccctg gcattctggt 746040 tcagggacat gggggatggg atccctcaag tccatgcctg gcggcaactt cgtaatgttg 746100 gctgtttctg tatttccaca ggtcacaaag gaactcttat gtcttctctt caaacaaatg 746160 gttagcacaa ttactgtagt ccactcaaaa ttaattcaca ctttaggcat aacaaaatct 746220 aggatgactg acacgtctgt cttaactcta aagaagatga gactggagag ttcaaagtct 746280 acctgaagaa aatgaaatat ttaaatatta agaaaagtgt ctctgttgct tccccacaga 746340 tttctccttt tgccacattt ggttcattaa tccctaagaa actccattgt gagtttgccc 746400 ttctttatac cgcagtgttt atctgttgtc cttgatagcg aagctttgct ttgtttcttt 746460 aaaaaaaaaa aaaaaaaaga ttcagagtct ctgaaatagc aacccagctg atatatcagg 746520 cgaaatctgg aaatcaaagt gatcccttct cattgaacat tctctatatt tggaagagag 746580 tgctacgtaa taaaatatgc atgtagaaat tagcaagtca gtttacacac tattggattg 746640 ttgtgttgga aaatctggta tccaataaaa agaaaattaa tgaaatataa atatagtcca 746700 tgctatccta acttaataaa atatggaggg aaatatttca aaaggagatg atatttatca 746760 tcccttcttt tcagaacaag catttttggc tgagcattaa aaaggattta atcaactaga 746820 ttggctccac tacactgaga gaacttctgg ttattttctt cccattttgc tctttttttc 746880 ttttttctcc tacctactgt taaaatggtt aataatgatt gagttatgca ccatccatag 746940 ctaatgattc tgtttacaat aaatactata taatttacac tgcatccctc tgttggaggc 747000 atttcatgcc tatggttctc tctctcaaga catccaggct tgctctgtcc tctagggtca 747060 accagtaggc atccttaccc tgcttcactc taggaggcgt ggccagtcca gcccagcctc 747120 ctctcctgtt gtgagcaggg ctaacctctg ccactgtggt tcgccattag ccttctcagg 747180 tgtggctcac ttaccaagct ctgtgtcctt cagactccaa gttctccgag agattcccta 747240 gagctcaaag ccctcttcca cccataagag ggaatactca cagacctctc tcaacagaaa 747300 atccttattc ctgccccagc ctcttttgga gcctggaaat ggatgactgg caaaacatga 747360 gaaccagcaa gtcctgccca ggtggcctca cagctcttgt taggaaagaa ggcactggca 747420 tctttaggag cattctcacg ctttaagatc atcgctaaaa cttccagaga acaggaagag 747480 tcaactttaa tatccagtta catatattcc aaagaaaata aatcaactct gatggtttaa 747540 attgttcagt tatcaacttt ctgcttgccc ttctactaag accaggaaaa ttgtgcctaa 747600 ttatggcagt cctcagagga atacacagtg gcatcaaagg gtggtgacat cagtgtaact 747660 aacttaccca aataaccaat aggagccact aacagcttga cgttattatt tttcatccta 747720 acctacggag aaattaagga agtttctatg aatatacctt ttttacttca attcttgatt 747780 agtcttctat ataaatgatg aaacaaatct tgttgcataa aaagtcatat tttattgttg 747840 attttagcca tgcattatgt tacaggcaaa aattaaagtg tgtgttttgg aggtaatcaa 747900 gaacgaattt taccttgtca acaggataag tatggagttt taactaaaag ctatgttgtc 747960 tacacagaaa aagatcttta ttttataaat atatcttaat gctttcctga tgcttaatgt 748020 tcagtaagag taattgttag aatttgcaca tcattaagct ttgtaaaatt aatttggcaa 748080 tgacatagcc ttggagaatc acacaatgca agtacataca gtctcaggat tgtctctttg 748140 gtttatcagg aaacaggcca aattccctct gaacttctag agggactaat tttcccataa 748200 tactctaaga cgtgactgga gtgttgtagt gggagggggg tggaggtgag gtgtaaatga 748260 gtgcatacac atgcacgtgc atgctagatt atagtgatgt atctagggaa tccatgcaag 748320 agtctctcca aatcatctga cactgtgtac ccacaaatta aagttttgac aataagtaat 748380 tatctgacat tatgttttgt tgaggaagca tgaggttgta tgacaattaa gagatatagt 748440 gaagatttaa atcccctgtt taattgcatg actggtattg taacttatgc agcctgctga 748500 ggcatgtaag gtttattgaa aagctaacaa gagtaaaagt aagtccttct tgttttggtc 748560 acttctaatt gacagcataa agtgtgagga aatagcacca gacttgggac cagaggccct 748620 gagctggagc cattgttctg cagttgtctg gtcttgtgac atcagtgaat cacttacttt 748680 ctctgaacct cagtttcctg atctataaaa tggatccagc tccacctact tcacatggct 748740 ttttaaggaa caattctgac ctatctaggt ctatgtctcc ttgaagttcc attagttttg 748800 tttcatgtaa taataaatcc taaacgttta ttcacctaat aaccaagctt catatctttg 748860 aataataggt gaatattagg tgaataaatg tttagaattg ttatgttctc ttgatgaact 748920 gaccccatta tcgttatgaa atttctgtct ttattactgg taatatcctt tgcttttaaa 748980 tctattttgt ctgatattac tatagccatt ccatattttt ttgattagtg ttatcatagg 749040 atatcactta agttccttta tttttaacct atttgtgttt ttatatttca agtacatttc 749100 tttctttctt tctttctttc tttctttctt tctttctttc tttctttctt tctttctttt 749160 tttttttttt tttgagacag agtctcactc tgtcacccag gctggagtgc agtggcacaa 749220 tcttggctca ctgcaagctc cgcctcctgg gttcatgcca ttctcctgcc tcagcctcca 749280 gagtagctgg gactacaggg acccaccact acgcccggct aattttttgt gtttttagta 749340 gagacagggt ttcaccacgt tggctaggat ggtcttaatc tcctgacctc gtgatccacc 749400 tgcctcggcc tcccacagtg ctgggattac aggcgtgagc caccgcacct ggcctatttc 749460 aagtacattt cttgtaagca gcatatagtc ggatattgct tttatatcag gtctgacaat 749520 ctttgccttt aatatattta gatcatttat acttaaaatt attattacta tgtttatgtt 749580 taactctgtg tagtgctatt tgctatttga gttctgctgc tgttgtgcta cttgttgccc 749640 ttgtcagtct ttctctgact tctttggggt tttttttgta attccatttt atttatctta 749700 ttagttcatt agctttattt tatgctatat tttgtaattt cagcagtttc cttacaattc 749760 acagcatata cttttaacat cttagtgtac tttcaagcgg tattacacac tttgcatata 749820 gtataagaaa cttacaatca tatacttcca ttttttcctc ccaacatttg tgctattgtt 749880 aaacatttta cttttattta tattatatac ccacattaca ttggtattgt ttttaactat 749940 caaccatatt ttaataatat ttaaataaga aataccatat atatgtatct gtataattac 750000 ctcctttttc tacttatttg tgtacattta tgtctctgtc tatctggtat tattttcctt 750060 ctgctggaag gactttcttt aacatttctt gtaatgtggg tctactggtg attaattctt 750120 tcagcttctt atgtatctga aaaaagtctt tattcacttt cattttgaat tatatttgtt 750180 gaatatagaa ttctaggttg atttttttct ttcagtactt gaaagaaatc attccactgt 750240 cttcttacct tgattgtttt tcaaatgaaa ttggctgcca tgcttatctt tgttcccctt 750300 tacacaacat ttactttctc tggctacttt taagattttc tctctagcac tgaaactaaa 750360 actcttgagt agtttgatta tgatgctcct tggtacagtt ttttttttta atattcttgt 750420 ggctagaatt cactgagtat cttggctctg cgggctacag ttttcatcaa atttggaaat 750480 ttttcaacca ctatttttac aacctttttt tggtcctgtc tctctcccct cctttaggaa 750540 ctccactatg tgcatgttag gcagcctgat atttttccat agctcactaa tgccctgtta 750600 acttttttat tctcttttct atgtatcatt tattaatatg tgttgtgaac ctcaaatatc 750660 tgagacaggt ctcagtcaat ttaggcagtt tattttgcca aagtgaggat gcgtgcccat 750720 gacacagcct taggaggtcc tgacagtatg tgctcaaggt ggtccgagca cagcttggtt 750780 ttatgcattt tagcgagaca tgagacatca accaattttt taacattggt tccatctgaa 750840 aaggcaggac aacttgaagc aaaggcggga caactcaaag tggggagggg gctcgtgagg 750900 agggggcttc taggtcctag gtagataaga gacaaatggt tacattcttt tgagtttctg 750960 attagccttc taaaggaggc catcagatat gcatctatct cagtgagcag agggataact 751020 ttgaatagaa tgggaggcag gtttgcccta agcagttccc agcttgactt ttccctttag 751080 cttagtgatt tgggggcccc aatatttatt ttccttccac acctttaagt tcactaatca 751140 gtttttctgc aatatctacg ctgctgctaa tcaagttcaa tgtatttttt atttcatgca 751200 ttatagtttc attttgagtt taatttaggt ctttttgtat catatctact taaatttttg 751260 aacatataca gttataatac cgctataata caattataac tactttattg cccttgtttg 751320 cataaatcta atgtctgtgc caattatggg tgaattttga ttgattgatt tcttcttatg 751380 aattatgttt tcctggaaat ttttatgaca gctttattga gatgtcattc acttttaact 751440 tcaacaattc agtggctctt agtatattca cagagttatg caacccttac cactatctaa 751500 ttttagaaca ttttcatcac cctgaaaaga aactgcacgc ccattagcag tcattcccaa 751560 ttttcccctt cccctaccct gcccctgaca accactaatc tatgttgcca tcgatctgcc 751620 tattctgaac attttaaatg aagagaatca caaatgtgtg gtttcttata attggctcct 751680 ttcacttagc ataatgtttt caagatttat ccaagttata gcatttatca gtacttcatt 751740 cctttctatt atctcataac actctgatat ggcttggctc catgtcccca gccaaatctc 751800 atctttaatt atatagctcc cataattccc atgtgttgtg ggagagacct ggtgggagat 751860 aattgaatca tgagggcagt ttcctctgta ctgttctcct cgtagtgaat aagtctcctg 751920 agatataatg gttttacaag ggggaacccc ttttgcttgg cctcattctt tcttgcctgc 751980 caccatgtaa gacatgcctt tcaccttctg ccgtgatcgt gaggcctccc cagccatgtg 752040 gaactgtgaa tccattaaac ctctttttat ttataaatta cctagtctcg ggtatgtctt 752100 tatcagcagc atgaaaatgg actaatacag actccatggt atcgctgtga catattatgt 752160 ttatccagtc atcaggtgac acatatttgg gctatttgtt tgtggaaata ttttagtagg 752220 tgttaaactt tgtgaacttc accttttgga gtactacatg cttcaatttc tataaattct 752280 ataaatattc ttgaccttta ttcttggatg tagttaagtt atttaggaat aatttgttct 752340 ctctaagtct tgcctttaag aataattagg aaagactgga gtggtattca gcctggggct 752400 aattatttcc cctttgtggt aagaccctta tgcactatac ccaatgctcg aggaatcttg 752460 atgttttcca acccaactgg tgagaacagc cactactccc atccctgtgt gagcattagg 752520 caccgtgacc tccaattctt tcaggtgtct ttccctggcc ttgggtagtt tcctcacatg 752580 catccatgga tctgctcagc tgaataccca agtaggaccc tcttcaatct ccagagcttg 752640 tcctttgtgt gtagctctct ttccagtgct cttccttgtg aactctagct tccttcaggc 752700 tctcagctct gcctccttag cttggaaagg ctgccaacct cccgagttga ggaggtggag 752760 ctctctattt tatcagaaat aaaatttaca ctgccctaca aattgcaaaa tctctgcgat 752820 tgtggggttt tcttcattcg tttcccatct ttcagagatc actgtcattt attacctgat 752880 gtgcaatgct tttagaacca ttgttttatg gatggtgtgt gttcctcagt tgtttcaggt 752940 gggagggtaa atctggttct tgttactcca tctcagccaa atacagaagt gctgtggcct 753000 gtaatgtaaa ggggtaaatt atttattggt ggccatcaaa gctgctgcag agaaaaatgt 753060 agatggtggg tcacttaaac ttaccagtta cattttatat tgcaaagcca gccttttaga 753120 ggagagtgag ttgagttttt ttgttatgat atttaatatg ttcatgacca ttccttcggg 753180 aaatccattt ttgccacatg cttctttgaa tgtgggaaca cttatgtctc tttttacagg 753240 tgatcagcga gtttgaggcc tctcccgact cgttttccta cagaattccc aacctgagta 753300 ggaatcgtca gtacagcgtc tgggtggtgg ctgttacttc agccggaaga ggcaacagca 753360 gtgaaatcat cacagtcgag ccactagcaa aaggtaggca gtggctataa ggacctcatt 753420 tcctgttgta acttgactgt ttttaagtct ctattttacc tgaaataaaa cttacacttt 753480 cctaaaaatc aaataaacca gaatatcaca ttttagctca agaaacaggg ttgtggctaa 753540 caagctctga gcttctgtcc catggaaaag taattccctg gaggtaaaca caaagctgag 753600 aatgagtggc cttacaatgg aagtgtctat gaaaattagg aaaggagccc tcattcattc 753660 cttggagtag ctgaaaatca ttacacggca ttttcccaag gatgttctac tttcagcaaa 753720 atcaggtatc acacttctta atgagaaatg tctattttat agtctatgga atttgcaagc 753780 ttaaaaatat ttgaaaatca ttcactatct gttgacagaa tgctataagc aaagacttta 753840 agtaacagca ggaagtagga gtcaccaaag aataaaaagt tccttaaagt gaatataata 753900 tcttcacatt tgtacgttaa actggtcctt aaaaagcaca cgcaggcacg gggtattctt 753960 gctcttctgg taatcacggc catccagtgt ttccaggaac cccctaaatt agcattcata 754020 ataagtcaat ttccttacga cacaattcca ggccagcagg agttgcccct aattttgagt 754080 tatagaacag tggcaactta ttactaatat gttctctgat agcctgaaag acaagaatga 754140 acattccaag attccaattt tacctccaag aattctctga aaaatgtgct ttttaatgag 754200 atagttaaga aataggcaga ataaagcagt gaggggaaaa aagaggggtg tcacattttg 754260 agctcaaata cagatagaaa ataagtaagt tggtaaggga aataaactgg gggacttact 754320 ttatgtatta cactctttgg tcatgatatc cagccactcc ctgagaatga gaaaatgatg 754380 attaccaagg aaaatgttgg acataaggac tgagctgtgg gatttaccaa aaaaacaaca 754440 aaaacaaaca aacaaaaaaa cactgcaaca aaacacatag gattagcaat aatgtttctt 754500 cctttccttt gtgctttcaa agttctatct ctagacacag ccagaaaggc ctggctagtg 754560 cagtggggta tgacttactc agtgggggaa caattgaaaa ctctcacaga agcaggtctt 754620 gcctggggaa attcaatgtc ctccagtcat ttaataagtc attttgagtg cctgttgtat 754680 gtcagggtct atgctgggga cacagaggat ttggtcaagg gaggctgact gctgaaataa 754740 atgttcccta aatctcagtg gcttcacata ataatatagt ccaacagagg tatttttggt 754800 cagggctctc ttgggtggcc tgttccacat ggtgattcag gcatccaggc cccttccacc 754860 ttatgattta caaccctgga tttctcctca tttacagcta aatagatggg ggaagaaggg 754920 agtatggagg gtttgatgag aggttttcat gagccagata cggaagtgta tacattattt 754980 ttactaatat cctattgtct agaataaagg catggaccca ccagggaaaa gaaaacaggg 755040 tttggagagc ccagaggagt cttttgagat ggtttaagag atgtgttcac tccctgaccc 755100 cctgaagctt acagtttggt ggggagccag tcagtgatat ggtttgtctg tgtccccacc 755160 caagtctcat cttggattgt agctcccata atttccaagt gtcatgggac ggacccagtg 755220 ggaggtaatt gagtcatggg agcaggtctt tcctgtgctg ttctcatgac agtgagtaag 755280 tctcacgaga tctgatggtt ttgtaaaggg gagttccacc acacatgctc tcttgcctgc 755340 cgccatgtaa tacatgccct atgctcctca ttcaccttct gccataattg tgaggcctcc 755400 ccagccatgt ggcactgtga gtccattaaa cccctttcct ttataaatta cccagtctca 755460 ggcatgcctt tattagcagc atgagaacag actaatacag tcagtaaaca aagcatcaca 755520 aaagtatatg catagagaca aactgtagta agtgctataa agaaatagtg tgagaggacc 755580 tcacctggag tgtcagatgg aggacacact tggtccctga gcacaagcaa aggcggttat 755640 gtgaagagag aagaagtgag cagtcagaag ctcctgcaga gaaagattta gcaggtggga 755700 ggtccaggac actggaccct gctggggccg gggaaggaac agtggtccca gagacgctgg 755760 gaaggaagac agggacctga tcatgctggg ttttcaacac tgtgttaggg atttcagatt 755820 ttgccgcaag agaaataagg agatggtgta gggttttaag caagggaggc acatgatctc 755880 tctttctctc tgtgtgcatg tgtgtgtgtg tgataaacct tattttttag aacagtttta 755940 gatttacaga aaaattgtga tgatagtaca gagagttgcc atttacctca cacctagttt 756000 ccctttttat agacatccta attaaatgcc tttcttacaa ctaatggcgg gtgtgctttt 756060 taagaccacc tggtctctct gtcctgaatg gactgcagag aggcagaaat ggaggagggt 756120 ggagaaggag atagcaagaa tgaacaccca aattctcaca tgagttagca taagtggagg 756180 cacgatttct tgatgaagaa gaccatggaa gaagtggatt ttgaagccag tgagaggagg 756240 tacagacatt tggaggggtt caatccaagg tgacgaagag ccattcactc agaggcatct 756300 gtgcactgag gcatgtcctg gctctcaaga gacatctggc aggaggcaga aattcaggcg 756360 ggtcagcgtc tggatatcgc ttacacctgg gatgggaatg agattggctg agagatggag 756420 gagagatgaa ggtgcaggac ggactctcaa agggagtggg agcaggcaaa ggaaaagggg 756480 aaaagccaga gaggcagcag agccaggagg gtgttaggct gtggattcaa aacagatgct 756540 tgcaaaagga gggagtggtc aggtgaggct gctgctgctg gaaagtcagg caaaaccagg 756600 cgaaaatgcc cctcagtggc cacacggaag atcgtggtga ccttcctgtg agcagcatca 756660 gtgggtgtgg aggggcatgc agaaatgagc ctgagtcagg tgagaaagtg ggtaggaggt 756720 gaggggcagg ctgactgggc agaacattcc ttcaacacac atcacctgga agaagtgaca 756780 accaagagaa gaagctggga gggggaggga ggctctcatt cgaggaaagg ctctgggttc 756840 attatttttc atgaggcctg ccatcagagc atgtttatgt ggtaacggga agatcccagt 756900 agagagggag aaacgagaaa tcaacaatac ataagaaaga gcccacgacc acagcactga 756960 ggtttagagg aggaaatgcc agtaggttca cagatttggt ggctggaaat gcagggttcc 757020 tggatggtgt ctctgaagca ttaggcaatt tggggatagt ggagggaagc ccagaagtgt 757080 gagaagagga gggacagcag gaagccatcg ttgcagggaa tggggaggac atttactaaa 757140 gaaacagtaa gaccagcagg gagtgctgac agttcaattg aggttgatga tcctaaatgg 757200 tggtcaatct ccaaatgctc tattgcgtgg attttttttc cagaaatgtt caacttttca 757260 tgcttaaggg aggttgactc agggttagga ttgctgtagg taggttttct ggaaagggga 757320 taagctaggg agtgcctcag gatggagcag acagtcagtt gggcagcccc cacccagaag 757380 cccagacact ggcaaaccat gaaggctgaa aggcccatcc tagagggatg gggatgtcca 757440 cagcagagga gattgagaca ggttattctg tagttgttgg gaagtcaagg cagaccagca 757500 gcagtctagc gacaggtagc agggtccaaa attcagatac agttgaagaa gaggaggacc 757560 actgctttta tggagggagt ggcagaatgg ggccatggca ctggtcctgg gggaagcccc 757620 tcctaggaag gggtccagga cacgaaggca cagagagcct ggccccatgg ctgagaacaa 757680 acgggacccg aatcagaggg gacaccaggt tgcagagggg ttcagtttct catcagaatc 757740 acctgggatg cttgtcaaaa ggcagatgcc ccaagtacag gaaagagctg ctgaatccac 757800 aaggctgtgg tgggaacctg cattttaaac aaagattcta ggggattctc ttggctgccc 757860 caggtctagt gtgttgagtt gcccagtcat acatttctgg ctagagaccc tttaaatttc 757920 agccgtctaa aatgggcaaa atgggcattg agcgatagca tgggggttgt tgggcttgaa 757980 gatgaagtag ctctagcttg tattttttaa attgctaatg gaaaagcatt cataagtcct 758040 ggagttaatt tgaggggtta tgcccagaat gttaaagaac aacaatggaa tagagtggaa 758100 cagagtcaaa tcaactagac tagactaaac tagggtttaa aaaagacaga aaatatcaga 758160 atgcatcaca tacagtgaag tctttattca tgcaactttg tttgcacata cacaacatcc 758220 caatgcatgt gtagcttctg gagtttgatg taaaacatat ttcttaaagt gggtgactgt 758280 tataaagctg gaaagcccct aactctagct gaatttctct agccacccgc cttttactgc 758340 tgaggacatt ctctactctc taaagaactg tctgaagtgt gtgaaaaaga aaatgccaaa 758400 agctaccaat gcaggaaatc tgatgctgcc taatcaggac ctttttgtta tcatgatgca 758460 aaatcagaaa tgtcaatgac tgatgaaatg ggccctgcct tagaatactt catctcagtc 758520 cagggaaatt gcttgaaaca tgggttttgc tgcaacaaaa aacaaggtcc agcttctaag 758580 ccctctggca ttttcttttt ctctctactc ttgcccacag tgcccagagg caaaaatgta 758640 tgatttggtc tggtagatcc tagtgactaa tgtgggtatt ctatactagg atggctgcat 758700 aatgacttgg ctctgggtac tctgcccttc cagggattct agagcttccc tgggggagcc 758760 ttctcctcat cttcctttgc caatgcaaac cctcaaccca gaaatggtgc aggggtctca 758820 catttgtccc atttttatgg gctctgaatc agttcaaggc tgccttccac ctatggtttc 758880 cggtctgtgc atccatcgag ggtgagctcc tgtaggggca cctgtttcct ctatgtcccc 758940 agctccatga cagtgtctga agcatactgg ctaaaacaaa ggacaggaga agccccgggc 759000 tcctgtttac accccagaaa gtaatgtccc aatgtatggc aaagactgag cagattgttt 759060 tcctctggaa gacttgtgtg tggtgtccct gtcagctttt gtgactcact gatggaggta 759120 gcactagaac ctctcattgc tggccacact ggacttcaag gcaagttcac cctgggcttt 759180 ttctgactgt cttctgggac ttctgctacc ttggggctgc accagtacca gatgcccctg 759240 gcagatgctc ctgtttgggc atctgaatca ctgttccaag caaatggttg ttcttcaaga 759300 gaggccactc tgaaaatgtt cattctcctt aatgtgtgtc ctaaagatca acttgctata 759360 atacagtcgg gaaattgtta agtagaactt gttccagttt tactccttcc cgtctttggg 759420 gcctttgtgt tttgtattgt ctactttctc tgatattaaa gtatatttta atgagcagtt 759480 tttgtgttga ggtaaattgc ttcctaaagt gctttgagaa ataattgggc tcatagaaaa 759540 cacagcttgg agctgcttgg cttatgaagc cctagatatt taatttggac tcctcatgtt 759600 tagtcaatag aagaaaagaa tgctacaatg ggaattttct gctagttgtg tgttcttaca 759660 atgacaattc ctcataaccc gggtaccaga gagtagtgtt gacagttgta atgtgaattg 759720 gcttcacatc catttttagg tattgccctt attgagtagg tcatgttggc ctctgtgtag 759780 acacgtctgt ggagtaatca ggattccact ttgtttggtt cctcagctcc tgcacgaatc 759840 ctgaccttca gtgggacagt gactactcca tggatgaaag acattgtctt gccttgtaag 759900 gctgttgggg acccttctcc tgcagtcaaa tggatgaaag acaggtaacc agtaacccaa 759960 tgtatgcctt cagtgagact ctaagagatt acatctgaca tactcaggtt gtgtctagtg 760020 gtctcctaat tttgtgttta tttatattag tgaaaactca aggaaaccta ccaattcttc 760080 tgagatgagg gcagagaagg aatctcagct ttagcactga aagggtctga tttattgtat 760140 caaccctctg ttaattcaga gccttctagt tcatgagaga atgcttgcaa ggaaagtagt 760200 tgaaccaact caattattgt ggaagtttgc tgcaccctct caggtaaatt gtccatgtaa 760260 ctgagatgaa tgcagccaag gctattgtga gatttaacac ctatctcttc ttctttaaag 760320 atagtgaact aaccataact caaataccct gagaaagaac tttaagaaat ggagtacatt 760380 aggactttgc taatttaaaa tctggttctc catactccat agtaattatt taaataatag 760440 gagccaagat agagggagag agtgagtgag atatggtctg tccatataac tttttaaagt 760500 gctatatctc tattcaggag aagaaattag gatataagtt aagggtcgaa aattcattta 760560 tgagcataga aatgtgatct aatggattca gaagaatgcc tattttcaag caaaagcact 760620 tagaaggcat aaactgtaga aataatggct tggtgtagtg accaaactgt agaaataatg 760680 gtttggttta gtgaccactt ttctcataca tttaaagttg gttcatccaa atgaaatatg 760740 tagctcccaa ggtcaagttg gcattctgcc tgttgtggga atgaccccaa aggactggac 760800 aatctgccac cggagcagtg gttatgatgg ccacgcagtt ctttttatac tagggtaaac 760860 tcatcaccct cttgagatat cacatgtcat ttttcatgtc aaaatcatga ataattgtga 760920 ctttaagtga atctaaaaat gatcccaagg tttagtttcc cctgtatgat ttgttcaaac 760980 tggcacttct gcctacagaa gaaattccca gaattgccaa aatgaggata tctccagtgc 761040 ccacagagtg gagtaaagag ggacccatca gtctctggca cagatgagga gtccactgac 761100 ttgagccaga atctgggccc ttgacacaga tctcatcttc aacgtaacat tttttacaaa 761160 ggaaaacttc agctacacag ctattgattg ttttcattat gtaatcatat ttagttcttt 761220 cataatgcaa gaaatatgaa gcttccaaat gtgtggtttg cttcacagag tctttctgtt 761280 tttccccaac ctcagctaat ttggattgta atttctttaa tctgtgcatt tttcttcctg 761340 tgaggcagta acgggacacc cagtctagta acgattgatg ggcggaggag catctttagc 761400 aacggaagct tcattattcg cacggtgaaa gcagaagact ccggctatta cagctgcatt 761460 gccaataaca actggggatc tgatgaaatt attttaaact tacaagtaca aggtacaaca 761520 tttgaggact ctttttaatg atatctttta catgtatgct ttctatgcaa aaagtagcac 761580 tgaacaaatt ttaaaatcag cccttataaa gagctaactt ctgtttccat attacagaaa 761640 aagaaaacac atgttcattt tgcaaaatat aattaaacaa atcaaagaaa atacaaagca 761700 ttcacaacct cagaaatact gagatacaaa acatctttgc atacagaaag cctagtctct 761760 tttttcttta tgtgtacatg tctaaaaaag tccttcttaa taatttccat taattgcact 761820 gtttactcta catatatgta agtgtatccc agaaaacaca aacaaaaaac aagtctgaat 761880 tgtggtcttt tttgtatgct aattaactca atttttatat gcaatgtatt ttaaaaaatg 761940 aaagtaactg gagctctaag tagatcgctg tagtatttag ctatgtattt aatactaagt 762000 atttttcttg atatcataca caaaatgtgc acaacttcaa aagattgtca tgttaaaatt 762060 ttgtgtaaat cccaatcaat aagtgattga gttcagattt gtatgcacag caatatttta 762120 ttagtagaaa aatcaaagtg tgtgcttctt tggatttagg tgttgtcaca ttaatagatt 762180 acagcaagta aaaataaaat caatactgtt ctcggtggga tggaaggaaa ggaaaagaac 762240 tatatttcta aaaatgctgc aaaattgatc ttgaatttca aattaattga agtcaggaga 762300 attccaggga attttggaag acaggcacta tattatgact ctgaagagat aggtcaatat 762360 attaggcttc tctcagagga aaagagaagg gaattttata tgaagctttc tatatgattt 762420 ggataacctg attctgaatt tctttagtgt ttctgccctc agaacccatc cagacttact 762480 taccagtatg tattctacaa gccttgtaag agagaccagt tcatattctg cagttcaaag 762540 gcctgctttt gattttctgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 762600 gtgtgtgtgt gttgcatctt ggagcaatag cttagaaagt gaagattttt gcaattcttt 762660 ttcccactag ctatttttcc tccttcccct tttccatcct gagaagaacg gaactgctaa 762720 gtggatgcca tttatctttt tcacttaaat ttcatggctg aaattcatag taaaatgagg 762780 catgtatcct tagtaagttt aaagaagatt tcaattagtg ataaataact cagacagtca 762840 aggaactggt gaggaaatga gttagatatg aatccaagta gaaatgtggc tgaatttttt 762900 tttaaataat agattcactc cgttctatct ctttagccca ggatatcaac taaatagaca 762960 ttttgacaga agtgaattgt atattttggc aaactgaaac acttatttaa taaatggctg 763020 ttaaaaatga gttggtaaat gactgttcag gaaagttaaa gatgtgaaaa actaattctt 763080 gttttctaaa aactgtttcc tctccagttc caccagatca gcctcggctt acagtctcca 763140 agaccacgtc ttcctccatc accctttctt ggctccctgg agacaacggg ggcagctcta 763200 tcagaggtaa taagatatag attgtccaca atagttgatt agttgtgtga tccacatgcc 763260 aataagtgac acatcttcag caaatgactg gtatgtgtta ctttattctc ccccaaaaat 763320 acgtcatata aacaatccct ccattaccta agaaagaaac catacattta tttttaggat 763380 atttgttgaa attcaaatca ttcatccaag gatgctcatt taagagtgaa atatcaacag 763440 ttgcaagaaa gaaagaaaaa agaaatttgg atatctcttt tttgagattc taaacactgt 763500 ttctttttta ttttgtcaac acaaagtcat tcatttatgt aaccatgggt actgtcctga 763560 cttagaaagt aataaaagac agaggaccta aagtgtagat gtaaaacaat ctatttgcac 763620 aaaacctttg caattagttc atagttgagg tgtataaaca agattttgtt ttgttttgtt 763680 gttttgagat ggagtctcac tctgtcaccc aggctggagt gcagtggcac tatctcagct 763740 cactgcaacc tccgcctgtc gagttgaagt gattcttctg cctcaacctc ccaagtagct 763800 gggattagag acacacacca ctgctcccag ttagtttttg tatttttact agagacgggg 763860 ttttgccatg ttggccaggc tggtctcgaa cttctgacct caggtgatcc gctcacctcg 763920 gcctctcaaa gtactgggat tacaggcgtg agccaccacg cccggcctaa atgaggttta 763980 tatggaagga gtgagcatgg tcgttctagt gtgggtggag ttaagctaga gacagaagat 764040 acacaggaaa gagggcctgt accataaagg aggtcccagg gccggggaga gagaataggg 764100 gcttagactt cctaaggcag agaacatcct ttcttctgag agagaaagaa ggctgggaag 764160 taaacaggaa gtcaggagca tttcagagtg acatcagtag tgtgctggag cagctccttc 764220 cagctccgag agtgaggtgc cacatccctt cccagcttca tgctcagtgg ccacagccac 764280 cctaagaaca ttccctcacc atggaaatca gaaatgctac aaatcagagc cttttttctc 764340 ctctccaaga accagttgtt aaacatttat cagcactcca atgggtgaag ggaagatctt 764400 tttttttttt ttttctttta ggaaagaaaa agtgaggtga tttttttaaa atcgtggtga 764460 ggatgtgtct gtggatttga ggagcatggg ataggtttgt aatagctgcc ttgtggaatg 764520 cacagagagt cattaataga tgaaccgagt cattgccaag aagcttgcaa ggacccagct 764580 gcagatgcac agcacaaatt gtacgagtca caattatcac tgtctaatga ctttcttttt 764640 tgttttgttt tgttgagacg gagtctcact ctgtcgccca ggccggagtg cagtggcacg 764700 atctcggctc actgcaacct ctgcctcccg ggttcaagtg attctcctgc ctcagcctcc 764760 cacgtagctg ggactacagg cacgtgtcac cacgtccgac tgattttttg tacttttagt 764820 agagatgggg tttcaccatg ttagccagga tggtctcaat ctcctgactt agtgatctac 764880 ccgccttggc ttcccaacgt gctgggatta cagtcctgag ccaccacacc tggcctaatg 764940 acttttctaa atgattctgg acagctggga agaaaagtgg atcacagatt accagtaaca 765000 taagcattgc cagaagtctg aagagtgaga gaaactaggc tccttgttga aatggcctac 765060 caaaggttcc aggctgacta gagaaccttc ttataggaaa aaaatagggg gcacctaggg 765120 atgggctcga gggaccctag gttttaggct caaatgaaat gaggcttgga ttctacaagt 765180 gtgagagcat gggagaggta gaacaagaag ggtgtgtcag agcacaaggt cttccagatg 765240 aagccagttt tagtgaggga gagtttccaa gacaaaggta acccagcatt cctgaaacac 765300 agtagtggcc aaagccattg ccatcatcag gaggtgtcgt aagttgtgtg cccacactga 765360 tggacactga tggcactgag gatgatagca ggggacaggg aactatacag gcctatcacc 765420 aaggattaga ggagtttttt gaggtggctt cgagggtgga aagtgggagg aaagcagagt 765480 ccctacaatg tgtagggcgg ctggaataca ggctgggatg tggctgggag caggtgcaca 765540 ggtatcacct gtcaggtact gaaggagctt tatggaggtc agatgaggaa cacaaaggct 765600 caggaaggag gagggaccct atggccacag aaggccagtg gtgagggaag gctgaaagga 765660 gtaggggaga tactgacaat gacctcagaa ggaggcatca gagatgagtg atcgccatgt 765720 aaggggtgtg gaaatcagca aacctgccca tttgggttta ggagacactg tagtgtgcag 765780 ggaaaaaaaa tgctttattt ttattaaaat ggagctccac aggacaggaa tagaaggtac 765840 caacccgttg ttgcaaacac accatgttcc aggccagcta gccagggtgg agaaggaaca 765900 tggctgcaga taacagggct gaaggagtta acaggaagaa tatttcagca ttcacagggg 765960 tgaagaacat gggcttcagg ctgactgcag gatctgcatc ctcctttcag cacttgggac 766020 tcaccgctta actgctctgg acttcagtgt cccacgtgtt ctgtgggaga gtcgtcactg 766080 ttccataggg ttgcagaaat actgtaagca aagggcttag gacagggctt ggcatggagt 766140 gagtgctcta gagtggacag tcatccttac tagttgtaaa agtagaggta gtgctcatgt 766200 gggggaatga attgttggag gaatttttca aaccaaagag aagccaggtt actgtcagaa 766260 tagtgggatg gctgcaagac ttggagctgt ttctcctagt gtctgtgaac tgtgagacca 766320 ggagtacatg aggagtgagg cagttgaaga aatctctact cccattgata atgtatccct 766380 ttcccagaga ttcgagtgtc ttgcaaaaat aacagcttca gcctatgtct tcactcaagg 766440 attcaggcat gtatgatctg agggacagat atttggcaac ttaagtattc cctgctgctc 766500 aatatggctt ttagaagaga atgagcagaa aacagcaata cttcacagtg ataatgtctg 766560 gtgtggccca aatgactcac taatcaatac atcatggtgc ttctcccagg ctgggttaca 766620 tttcctggaa tcagaaagag cgaaaatgtt ccttctgaag attcttcagt tctgagaatg 766680 ctcgttctat tacccacaca aaatgcaagc atcagtccac ttcccataga aagcaaacac 766740 agtgctcatg tgaatctttc tcattctctg caggatacat actgcagtac tccgaggaca 766800 atagtgagca gtgggggagt tttccaatca gccccagcga acgttcctat cgcttggaaa 766860 atctcaaatg tgggacttgg tataagttca cactgacagc ccaaaatgga gtgggcccag 766920 ggcgcataag tgaaatcata gaagcaaaga ccttaggaaa aggtaggtat gccttctcat 766980 cgcttcttaa tatcctttct tttcccggcc agaagaggag attggaatca taaaagatcc 767040 atcatgtttt acgtttatgt gtttgaactt tgtcattcct cacatggctt cagcagtgcc 767100 acggcataat gagagggaca gctggacctt ccagagtgtt ctggtcctct cttttattgt 767160 ttcatttgca gttaaaaaga agaatgtcag tttgaaaatc aagggcgttg gtgtgaatgt 767220 gaggtgccaa ggctgggcag ccatgaagcg tggcgcttgc cctctcagcc gtttggaggc 767280 gcccttctcc cttagccacc cttgctccca ccttcctatc atttccacat tgccacatag 767340 ccaccgcttt tcagagggaa aatgatgggg taaattgcgt ttgttttttt tttaatctaa 767400 aatgtggact ttcaaggaga tgaatcccaa agaaatcata ttcagagaaa gaggttttgt 767460 cccaggaact ccagaaggaa ggagggatga tgcagctcta tgtgggcata ggaagaaggt 767520 gaggagatgt ctttgcaggc ttccctccca taggagtcct accaggtggg gtggggtcag 767580 atggcaggag agcgagtaat gagatagcaa gggtattatt tgtgcctggt gccacagttt 767640 tgggtaacaa gtggtaagag gtcaaatgat cggggattga tttatgcaga aatatatcct 767700 ttaggtccct gggcaccaag accaagtgtt tagttgtgga ggaaaatctg ttggtgcttc 767760 ccaaatccaa ctctgtcttc tcttgaatca ggttcatcac atgaggatgg aaaaagtgcc 767820 cagcacactg ccccgcaaac cacagaagga aacccatatg tgaacatcct attgttcttt 767880 agggaactct aagatacccc aaaataacct ccacccatgc aattttctgt cacacaccca 767940 ggtcattaca gttggagaaa gcctgttggt ccataaagtc tctattaaca ggggacaagt 768000 tgccagtggc ctgtgagcca gacttggact gagctcctgg cctcgctgga ggaagcagtc 768060 cgagggaaat gcgtgaagat gctgatggcc tccccatgtg tcctgtgagc tgacctccat 768120 gtgccttctc ccccagagcc ccagttctca aaggagcagg agctgtttgc cagcatcaac 768180 accacacgcg tgaggctgaa cctcattggc tggaatgatg gcggctgccc catcacctcc 768240 ttcacactag agtacaggcc ctttgggacc acagtttgga ccacagctca gaggacctct 768300 ctctccaagt cctacatcct gtatgacctg caggaagcca cctggtatga gctgcagatg 768360 cgggtgtgca acagtgcggg ctgcgcggag aagcaggcca acttcgctac gctgaactac 768420 gatggcagta agctggctgg ctttgtggct ctcctgcttg tgtcttgggg gatgtgcacg 768480 tgggccctgc ccctttccca tcgaacatca tctttgccat agtttgacca gtgcccacgg 768540 agcccattag gctttcggga ttcaatggac tctgtctggg gctccctagt tcgttatatc 768600 cagatgacca tcactgtgtg tccagaaata agagactcag ggccataggg agtctcactg 768660 gggagtcatg gggcaggagt gatttctctt agggctgaag gactcttgac cctgtggttc 768720 tgtgcttgtg ttgatgtcta tgagctaaca ttgcttttgt tgtctcccac ccctttcccc 768780 acctcatccc aatccacata acaactttct tttttgcact cattacaccc taaactgcat 768840 gtgcaaaaac aattttccat ggtaaaggag cttatgttag tctctgggca ggagcagggc 768900 cactgatgga aataggataa taataggaat ccatgaacac gtgcacacac acaaactcac 768960 acacacttgc cacttgcatt tactttccaa aaactaggtg aggtgtctct tgacattagt 769020 taaccaaaaa taaatggttt aaaatctcac tcattttttc tggtatcaag ggccatttat 769080 tgctaactga acaaatgcta agcccagtga agctgaaagg agcgagtcct cgactgcaac 769140 ttagtagggg aactttagaa agtcccagca gcagcgggct gatgctcatt tctcactagg 769200 ggaacagcaa ggattgagtt aggtgctcta attgcaaggt aaaaacggca gcaatgcatc 769260 aggatgagtt ggaactccag tgcaactctc ctcagagcct tctattcact gcctgttggt 769320 caggctagac cacagtgttg aatgagttaa ccaagaaaca cccaaaccct ttattgacag 769380 ccaagccaag accacgttgg aagtgctcct ctacctgtgg gtgatgcttt gtgaggggat 769440 gcctttcaat gaagtcactc ataactgagg gctgtaaaat tagacagagg cagcccatga 769500 aaagcatcag cattgctctc taggagagtg attctttctt tactttgtgc atttgggagg 769560 ccgctttatt aaagctccag caggtagctc cttggagcac agtttatgcc atcctaagaa 769620 gagtggctgt gaacctaagg acccacagaa atgaccacca ggagctaatg aggtgacatt 769680 gcctgggatt ttcatcggac caatttctcc tataatgtcc ggatggccca gggctggctc 769740 ttcttgcttt ggcacacaga gcagacctac cccaaatctc ctgtccaagg tcatttttcc 769800 acaacatcct tctctgccag agtccagggt cttcctggca cttctggcct gggtctcagg 769860 gctgtaggaa gaccttgagc ttgtagaaag ctcttctagt gttggttacg ctagccgggg 769920 tccctggcct ctgcacgggc tctgtcctat ggccccagaa tagcctatgc cctcccagac 769980 gacaactttt ctcttcaagg gctgatgctt ttcatgggct gcctctttct aattttatag 770040 ccctcactct tcagtgactt cattcaaagg tgtccccatc acaaagcatc acccagaggc 770100 agaggagcac ttccaagctg gcctctccct gtaatatggt tgaattattt gatcttacaa 770160 aataaagaac tttgacactt accagacact ttacttagca tttaagggtg caccaaaatc 770220 ctctgttaac cagcacacat ttgagtagta agtatctttt ttactttaga tcattatctt 770280 gcaatattca cactctggtt cccagcttct ctataatatg tgcagatgcc tgggcaccca 770340 gcttaaatgt gcacactgat gatatgctca cagctaatga tttaattaga aactactcat 770400 gtgtagaatt tgaaactgtg attctaattc acaaagtgtt ctgcggattt taaatgtttg 770460 tcttctaaga aaagatataa ttttctcact ttatccaaga tcccaaattt tgaaaaatgc 770520 tgcaagctac ctttacgttt tggaaatatg aaatcacttt attacactaa gaaatatggc 770580 tgcatattta tattttcctt gagagagatt acagatttct ttggaccagt ctcatgaatg 770640 gatagcctct attgtcacat ctgcctgaag aactttgtta tcttgagaaa gccaagattg 770700 gcagcctaca ttcataccac tcaggtttca gagtcctcca tttaatgatc tcactctttc 770760 ttctgccatt tccttagccg aatgtttctg cttgacctag tgttgtcttg gttttgcaga 770820 cccctcttca tgggcatcct gtaagtgcct ctttcctgaa tttctaagca tttggagact 770880 tgggcttcca caaaaacact ttaaagttgg gagaacactc ttctcagctt tagcagagat 770940 cacagaggaa cgaggattcc attatccctg ctctgcttac taaatgcagg ataaagaccg 771000 ttttgctgag ggagaaatta tattattttt gcattctctt ttcctgaagt gctgactttc 771060 tggcccttgt tgtacatgga aagtgcagtg gcgtggagca tcttatataa tggagggtag 771120 caaaatatat acctcataaa aagtggatgc ctgtgtttag atctctgcac ccacggtact 771180 gagcatctgg atagaaggca gcttaagata gctcagagtt catcttcctt cagtgtttcc 771240 ttattactcg aaataatcta gattttgtag cactatttaa ccatgcctga tcaaaagtag 771300 gctcctttag aaacctagtt gggtcccctt tgaaaagctg tctgtagctc ttgtaccctc 771360 aaaccacagc tgttgaagta gatttggtct tacacctgcg ataaaagcca gcaaattacc 771420 taatcacaag ggatttgagt ttctttatgc cagtgtatct aggaccctct ccctgcacac 771480 gcgcttctgt ccatttgccc aaccttttgt tcattctttg atgtgcaatt ttttcgaata 771540 gtctctatca attgtactgt gggtgacagt caagggaaca cttaattctg ggtagatgca 771600 tgtggctttt gtcagcacca agcctgggcc tcatgctttc aagtgcctgc acactgtagt 771660 gcattgcaaa atgaagtcct tttcaaacgt gcactataga ataagttgga agttcaggca 771720 gagggaggga aataaataag aaaaaaagtt agccagggcc tagagacaga gttcttttca 771780 tttctcatca cctccaacac ccttggatca cacagcgcga tttttataac ctgtcatccc 771840 taaaagctcc gccatgccgt cttcattaat agccatctaa caccgtggcc ctgctttcag 771900 gtacaattcc tccactcatt aagtcagttg tccaaaacga agaagggctg acgaccaacg 771960 aggggctcaa gatgctggtg accatctcct gtatcctggt gggggtcttg ctgctgtttg 772020 tgctcctgct ggttgtgcgg aggaggcggc gggagcagag gctaaagagg ctgcgaggta 772080 ggtccaggcc cagctgtcca cctacgcgtg tcccctgctg ctctgcagcc aatgggagag 772140 atgccagctg gagaacaaac ctcaaaaggg agtgactctt ccctctttaa cccaggtccc 772200 tccactgcct ggttctctga cattccttca gcgagactgc agagcctcag ggaagagcaa 772260 taagaatgtt cctatctcgg tcagaaatca ggtgaaagcc aacctgtccc ctaaatccta 772320 gctgttggta tgcaaggaaa attaattttt taactctagt ctcttaaatt ttcagtgggt 772380 ccagcaaagc caccaattgt ggctttctat gaaaagatct atcagatttg ctctgggaat 772440 gagaattact tgactgactg gaagtggaaa ttgagggctt aggatactgg tgaagcattg 772500 tgaggcagag gacacatgcc atcccaaatt agaaacggga gctgaagccc agtgtaagag 772560 tttcactcta atgtagcaaa aacataatga aggctggaga agccaggcca gatgagctcc 772620 attgtgaaca gacaccatga ttataatgtc cagccccgtg tcgttctgtg atgaggctgt 772680 tctcagcttc tggccaagag cccttacttg cccttgctct gcaatgtgag gacagggagt 772740 tatttcaaat atgaaactgt gcagacgtgt tcccaggtcc tttgcccttt accagtgagg 772800 gtgtttaact aagccacttt ttcggtaacg tgtattacaa gggattttca ttttaatatc 772860 agtgcagtgt gggatactgc tatgcagcat cctatgtgtg tttcaaagtt atgttcaaag 772920 tacaaatctg gaagcactct ctcctcaaaa catatcccaa actttactga tacatttaga 772980 aaacgttgac ctcttctgta aatacttaat ttgaccataa tccacttaga gcagagaaca 773040 tggtaatatt ttcacctgtc ttcacttatc caaagcacca aagcactgct ttttatggaa 773100 ttctggtaca tttcactatc aacttgcttt tgctctgcca acaaattaca attctgaagt 773160 acattgtact tcatctgtac aattaagaat ctgtccatgt aaatctcctg cagcccaata 773220 attcaggtca gccatcagtc tccttgaaat gttctttcgc aatcgtgcga accaattatc 773280 ttttaatttt gcagacatta cttgagtgaa tgctaggtgc ttaatacaca aagatgagaa 773340 gaaagagctt tctgaactct aggtttaagg taggaggtag gcccataagc agctaccagt 773400 gaaagacaaa acatgtcatg aatacagaaa tagggcttca aagaaagacc gcatcagtga 773460 aaaagaagga cggattaatc ccaagtggag aggaaaaggg aggctacttc agtgctaagt 773520 aaaacagaac tacaagcgta taatacagcc cattatggtg agaagttcca tataatgtgg 773580 accatgttga attccattca gttcatcact aaaacacaaa aaggatgttt tcataaccct 773640 tgttcacagt ggcctggact ttaggagaat tattatgaga taccaagggt gtctttcctt 773700 gttaccatta gacaactatg tctaactact tgcatttaga aggctgcaca ttgtctgtat 773760 gatgtttcta aaaaccaata gtaaatattt cttattaatg attttgattt aatcacaaga 773820 gttaagcatc taggtaatgc ttctcatcgg tctacaccct cgccaaattc actttttctt 773880 cttttccctg actcctattg ctctccatcc ttctcagcta ctattttatt tttcctactc 773940 accttcgaac ttgagcaccc cagctgtgca tttcctctcg ctgagagcac ctccagttaa 774000 aggtgctgtg ggctcttact gagtgaggcc tttgggttga aatgatgacc catgcaccct 774060 gtatttgtat tcttagtagt tccttgtaat ttaattgttg ctgtacaagg gctatctcca 774120 gaaaacatcc tggggctggc atttttattg ttggcctccc tgcttccaga cactagtgtt 774180 ttgcagttgg ttttggtaaa gacagcagtc tatcacctca gagaacatgg cctttcattc 774240 tccggaaata gttttgattt ctatgttctg gggaaaaggt aaatccaaca caaaggtttc 774300 agtaggaaga aagtaagtgc tgagggaaag agggagtatt actaagagat gttaaggagc 774360 aaaggatttc agaaaagtag cttgccatgg cacaaaggta tctgcagttc ggcattttgt 774420 acatggctaa taaagggttc tctcaaatca agaatctgac aggagaggcc gggtgcggtg 774480 gctcacacct gtaatcctag cactttggga ggccaaggtg ggcggatcac gaggtcagga 774540 gatcgagacc atcctggcta acatggtgaa accccgtctc tactaaaaat acaaaaaaaa 774600 ttagccgggg gtggtggcgg gcgcctgtag tcccaactac ttgggaggct gaggcaggag 774660 aatcgcttga acctgggagg cggagcttgc agtgagccga gatcccgcca ctgcactcca 774720 gcctgggtga cagagcgaga ctctgtctca aaaaaaaaaa aaagaatctg acaggagggc 774780 ggtcaggatg ccaaggattg ggtacccaat ttcacaccac ttctgaatgg caagttttaa 774840 tgtagacaca ctgcaataaa ttcagtttga caaaccactg tagattatct accaggtgca 774900 agatggaacc tttttttaaa ctagtggtaa catttgctgg ttgaccattt ctatttgatc 774960 acaagagttt agccaggtcc tagagagaga agagatttct aagactcaga actataaagg 775020 tgacattgta gtggcagtgg gtcaaggctt gcaaggggca gactcatctc cgtaactgtg 775080 caaagcactg ccataaaagg acagcgccag aggtgagggt ggtaaagggg aatcgatgaa 775140 aggtcaggca ttgccccaga aagacgtttg tttcttagcc ctgcagggcc ctgaaatgtt 775200 cattaatgat acaaagtatt ttcaactcac tcatggaggg aaattgcagc tgcagagttt 775260 aaaggaatag gtgcctgtct attaaatatc cggagtgcat tagtcgaatc acccaataac 775320 aagcgaaccc acataaggta cagactctgt gcctctggga gaataagttc aaatatattt 775380 acagactcta cagacagaat attttgattg tcaaaattaa ggacaacatt tctagtaaca 775440 tgtcagtgtt gcgtgagcaa ccatctatca ggatcaaaaa tggaaataag gagatttgaa 775500 ttatagaaaa atattatagg gatccccagt ggatgttttt agagtgatta ggtgggatca 775560 attttatatg gttgaaattg atcacatttt tcaattgcta gaaacagcaa aaatgtttat 775620 aagctgagta tgttttactg tatagacaag taacctagtt agatgaatat aatataatgt 775680 tattttatgt aaaattttag aaagaaagaa agaaaatggg actctagcag tgtcgtcaac 775740 ctatattctc tcttcctgag tactttacta attttagagc atggcgacct cctaaactct 775800 aaattgcctg caagtgccca catttttttt taaatctata accttatcca ggagttcagg 775860 agccgcattt tgcttttaat gatgccctgg tttttcttga acttctagat cctttgaagt 775920 gcaaggttat agagtgagtc actggttggg cctgagatcc cagcagccct aaccttataa 775980 aatgtgatcc cgtgtcaagt aatcaactcc aatatttcta aaagcctcct cctttggtac 776040 gcatttacgc aagaaggcac aagcttctgt tggcaccagt tagtgtgggt caacctgcag 776100 gacttcaaat aagctaaaga taaaaatcag tgagtgatgt cacatttgac catgcttttg 776160 tggcagagtg tcttgcttct cttgaatgga aatgtgttta ttattttaaa catgctttga 776220 aatggattgt tacaaaactg atcaattccg gaagagactg ttcccagaga ggatctgggt 776280 tcatggtgct atgcaggcag attaaggggt aggttatgag aaatcattgt tattttctga 776340 gtactaacag gacatttatc tgctctgcaa atgagcccaa agctcccctc atttggaaaa 776400 ccaaaaggta acttgaactt tactaaccta aagcaggaat gtgcatccag gaacccagtg 776460 acactcagac ttgagataga ctcaaagttt caatagatgc cccagcacta atgcataaag 776520 ccaccctgaa tgtgggaagc ccacattgtt aatgcatgag tagcacacat gcaccctaga 776580 gctttcgtta ccaagtgtgg ctaagatggc attagaagcc tgtactctga aactctttag 776640 ttctgtgctt tgtgttttct ttctttcttt ctctttgtct ttctttctct ttctttttct 776700 tttcttttct tttcttttcc ttccttcctt gcttttctct ccttccctcc ctccttccct 776760 ccctccctcc ttccctacct tccttctttc cttctatcct tccttccttc tctctccttc 776820 cctccctccc tccctccttc actccctccc tccctccctc cttccctacc ttccttcctt 776880 cctttcccct tctctctcct tttttctctc tctccctctc tctttctctt cctctctctt 776940 tctttctgtc ttggtttctt aatgaaatta ttctcttaaa acatcaaact tgttatggca 777000 aactgaatag aaaaggctct ctgcatctga cagcgggaag caaaagagca tgggggtgag 777060 ggggagtcga gggctaccag tggaggggag ccagggagtg ggtagtcagg aggggattgt 777120 gggtctcagc cgggccctgg agctctgcct tgcctgggtg tcctattttg tctgtgtctg 777180 tgcatgcagt tttttcagat taccagtata tatggccttc tttttttaat atatgtctgc 777240 cacagttttc aaattagctt tcatctgagc attgtgatga ttggaagtcc tatttgggat 777300 cttataaaaa cataaatgca ggtttatagc ccttgcaaaa atagctactt tatgagacta 777360 tttcaattcc acagaaaggc agggactgtt gagggagagg ctgcaaataa aaccttttga 777420 tggatggtaa tataaggtca aaatctgcca ccctcagaaa gtttttttgt ggatatctgc 777480 aagtgactgc ccagtagaag tattaaccta agcgtcttcc attttacgta actagaactt 777540 cagatatgaa aatgtagcca tgtggctata aacaagattt ctctttttta aagaagcatt 777600 tgagtgtgca aaatgtgagg cagttcagcc tctcaagctt tgcacagctg cagtgcctgg 777660 ggccatggtg ggcactctcc cacgccatgc tgtgtcatgc tctgccttgc tgatgtgcac 777720 cttcatgcca ggcacaaccc caggatgcaa gctgtggtct ataaacagaa cacaggaact 777780 gggcaagacc aagctgggag cctcctcatc caaccagagg tgccatttcc caaaactcga 777840 tctaaccatg tactaatcca caggctacta atgcttccca ttgtttcgct cctctttctt 777900 ctccatagta cttcactata caccatcctg ccttagtctc tcaatagcca tgcaaaatgg 777960 ttgagtatga actgcccatt atgatgcccc aattttcttt cttttctttt tctttttttt 778020 ttttttctga gacagagttt tgctcttttt gcccaggctg gagtgcaatg gtatgatctc 778080 agctcaccac aacctccacc tcctgggttc aagcgactct cctgcctcag cctcccaagt 778140 agctgggatt gtgggcatgc accaccatgc ccggctaatt ttgtattttt agtagagacg 778200 gggtttctcc aagttggtca ggctggtctc gaactcacaa cctcaggtga tccgcctgcc 778260 tcagcctccc aaagtgctgg gattataggc atgagccact gcgtccagcc atcatacccc 778320 attttctgac gtgaaaactg aaggccagct atagaattat ccagaatcac atatgagtcc 778380 aggcagagct agaagagagt tcagatcaat ctccctaccc tactcctctt gccatgaaac 778440 ttctgcagga ttttgaatat tcaagtaaga aacaggttgt ctcatcaata ttaagtaagc 778500 tctaaaggtt tatcaattat acctggaatt agaagatgta ttaacacagt atcaatagct 778560 actatataat tttatgtttg cccatcaaaa atacttggtc tattgatttt gtatttcgat 778620 attcactacc cttcagcctt cccctaatta tattttaaat atgtatatat tatatacaga 778680 gagaggcaca tatacatatt ccttctagct tgcatatctt catcctactg tctctctgat 778740 tcttttctcc actgaatact tgagagtatt ctgtcctcag ctacactacc tctcaattac 778800 tcccaaattc ccacagtccc cttccactcg ccacccaaat gtaactgttc tcctgaagac 778860 agatgaccag ttattctctg atctccaaat tatcctttca gccatcattt tttagccctc 778920 tttgcagcat tcagagtgtt agcaaatgtt gtcttttgaa attccttcct tccacatttt 778980 aatatcacta gattatcctg gtatcatttc tccatcattt cccagcccaa cagataaggg 779040 aggagcccag agccaaggat ggaagtgtgg gagtagcaag cggctttaga aaagatgtcg 779100 cgaagtctga atctcaggct gatctgaaat gtgtgggaaa aaatgtgaca ggcaatgcaa 779160 gggctgttta gctgtgtttg ggcaagaaga acaaggctgt gaacaatgtt ctcatattaa 779220 cagatggcag gtagacagga gagctgctca gcatctgctt tgcttgatgt gtaccaggag 779280 aaatgctatt tgaatcagaa aacgtggacc aggaattata aaaagaagga aggaaggaag 779340 ggagggaggg agggagggag ggagggaggg aatgagggga gggagggaat gaggggaggg 779400 gaggggaggg gaagggagaa actcaggatg cttatgaaaa taatcagcac cctgatagtt 779460 taaaaggatt tatttttttt caaaacatac tctgtattag ccattatgtg gaggtggaga 779520 tgttgctttt tgcagacaat gtttacaaag aactattaca caagttccaa agcgtaagca 779580 gcctaatgca gacagaataa atgctgtgct gtttcactga aaggaaagat ctccaccact 779640 taaaaaatta gggaagctgt catggggttc cagtcccatg attctgaagg ataacatttt 779700 agggttctga acaaaatttt tccagacata accccaagat ctttctggat aacctttgaa 779760 caatcaaatg taaattagag gtgttagaaa atgattatgc agatggtccc tgacttacta 779820 tggttcaact taggagtttt tgactttgca atggtgcaaa aatgatatgc attcagtaga 779880 aactgtattt tgaattttga tctttgtctg ggttagtgat atgtgatcca ttatttttac 779940 atgagatact caacacctta ttataaaata agctctgtgt tagatagttt tgcccaactg 780000 tagggtaggg taaatgttct gagcacgttg aagataggct aggctaagcc ctgatgtttg 780060 gtaggtcagg catattaaat gcatttttga cttaattata ttttcaattg atgatgggtt 780120 catcaggagg taatcgtaag tcaaagagca tctagaccct ggacccattt tcaacaacaa 780180 tagattaatt ctggacatta tagactgaaa taagttagtt gaggttatag aaaggatgtt 780240 ttgtgagcaa tcagggaagg gaagggacca ccaggggccc agacaaactc catttgcatt 780300 ttgacagggc tgattaataa gggtacacca ggatgtagct gaaagcatgg gcaggctaat 780360 ccaatcttgg aggccacata catcctggtg gggaagctaa tgtattagag ggacaaatcc 780420 acattttaag agattttgaa aggctggaag caagaagata cagtttaata ggaataattg 780480 tgaagtcttc tatagaagtt gtaaaaaaaa attcatttgc aacacgtata atgagcattg 780540 tgctctccct agtgtgctag aagatcaaga attaccagcg tctttctcag cctcatttta 780600 tagagaaata aaaaaatcac aaacctttca aagaagagat tcccaagtag ggaattacct 780660 agaaatcatt ccgtatgagg agtggctgag aaaattagag aatgtaaccc agaaaagaga 780720 aagctgaggc caagcaaggg aaatgcagct acatggaaat atctgaacag ctggcaaatg 780780 acttcaggtt aaaattacat caaggaattt ctgcacaaga aaaggaagat gtctctcaca 780840 attaaatgtg tcctcaggaa atctttgtgc agcttcacta tggatcaggg acaggactgt 780900 gcccaaaagg gccaagagaa agacaacccg aaaacaggtg ggcacagtat gagctgggaa 780960 gggctgtctg agatataagg cagaggtcca gggaagcgga gggaaccgaa gcttcacccc 781020 tgcctactgg gcatgggagg gtacacggag caagttgcgt ctgcatgggg cggtggggac 781080 gatggagggc tttgcactag caaagtcttg ggctctctgc agaaagtggc aagtgcagga 781140 aactcagaga gaggttggag gttacaagtg agcggcagcg gagccggatg acagcttgga 781200 ccagcacgga aggtgggttc tctgtgctaa tgagggctgt tgcagtgagg tccctttgaa 781260 ggtttcaaag cacaggtatc actcagtaag atggattcca gtcttcaccc ttcctgcagt 781320 gtgggtatca gtgttgggca caccagcagt aaggatgctg actaataagt gagattagga 781380 ctgagaagag aaaaaacaaa ggttcccctg gggacatgct ggctgggaga gacctgcaga 781440 cctggaaggc aggagagtac tgggaggaga ggaaggacac taggtgtgca gcaggagcac 781500 cgaccccaac cgtggagtgg cagtggcccc agctctggat tcatgcagac agagaatatg 781560 tgtacgtctg tgtaagacat tgtgaaaggg attccaacat tcattaggtg gccaatctga 781620 aaagtcttta ttgctcttaa gattctgtga ttccgggact ttaaattttt ttcttggctt 781680 gtctcagact ctcttctcac cctcaacaaa agtgtgtccc agatgagatt ttgccatctt 781740 ctttttgcac tctctctatg gggatatgaa aaacacccag accctcatct cagccctggc 781800 atctttccaa atttgattcc aaatttgcct ctgaacagcc tcacctaatg tcccccgata 781860 ttgaaactag acaagtctct cccaagattg ctgcttccat gttgttctag tccattcctg 781920 tcactcatgt tactacatcc agctctgcat atcccaaatc ttgccctttt cctggactcc 781980 ctgcaactcc tccttgtccc actgtacacc tggtaggact ctgattcgta cagatttcct 782040 ctatcttcac attataatgt tacccacata accctggctc tcttctctaa tgcccagagc 782100 ctctcacttg gactaaggac taagaagctt tcaacaagtc ccaggccccc acctccacat 782160 tcagagcatt ctggattgcc tggtggatgc tagttcacag cacccacacc catccaccac 782220 ccacctctgc cctccttttt cctctctccc tttggcccag gtagaagctt tcaggtcagt 782280 aatacaaagt cacatctcct tagctcttta atgtctagac tgtgcaccag accaccatcc 782340 tggcaacttc tctgtccagt caaattgacc tagactttac ttctcaaatg ggctcataat 782400 tccgatgcat gtgaattctc tgcatggagc acactgccca ttcatggcaa agctccccac 782460 gtcccatgct cctttaaggt ggggtcagtg ttaggtttag ggaagggttg acccaaacgg 782520 tcaacccttg gcatctagac ctgtgaaaga ccttagcctt ggggaggatg cctgcacgtg 782580 gcagccaaga gaggtctgct gtcggcatgg cagtcattgt ggggagctct tttctccctg 782640 ctggactccg caattcctta gtacattgcc atgaacagct cataggagag agctgtgatg 782700 actgaccgag aataggaaaa ggagagatta ttgtggcggg cagaatgagg aaagcagttg 782760 atcagaagac aattgaggct gagaactctt tcaagtgtga actgaagtgg gatgtttact 782820 ccttgaattt gtttccccct ttttagagta ttgtaccagc cactgcttgg tagttcattg 782880 gagctaatta agtccaggct tctggcatta tatgtatgtg tatatatatg tgtgtgtgtg 782940 tatgtatata tatatacata catgaagtat atataagcac atatatatat atatatactt 783000 tgtaagtgtt aaatcattca gggaaagagg aaattcatta tatttactgt gtctttgcag 783060 ataaatataa agacatgaac tgggaaatcc aatcctattt tgatttcttt tctttgctgt 783120 gtgggtggag tatatgggcc ctgtttcatt gcccaggctg aacccatctg tgcacaaaac 783180 caggccccat cttggggtta ccattgggac tggccaactt aacgaactaa gcttggctca 783240 tggcaaggac agcctctacg tggtcattct gtgactgtcc acgtctttca gaaatagcat 783300 gctgcccact gtgcagaaac tgactacgtt taattgtcag cccccaaagg catgagatgg 783360 aaatgctccc acatacgtat actttcactg cagagctggt cacactgtca gctgagtcca 783420 tttccggaaa gttctgttca ttgaacagta tacttagcat caagactttt tagagagcaa 783480 tgaaataaaa acaaaaagaa ggtttttgtg ctctaagtaa ggaaacattc atttttgcca 783540 ggaccaaatg tgtaaaaaga ataaattata ttttaaagga aacgggaatt tcaaaataac 783600 accaccaaaa aaagggattt tttttttcct acacttttag tcaggattcc ttctgtcaag 783660 agtggtaacc cggtcttggt aaacaatgtg ctcagagaaa aaaaaaataa agttttttta 783720 atttctgaat tcaaaataaa catctaagtt tccaggaaca tttatatttc atttatacga 783780 ttctttggtc aacccaagga actcagagct ctgtaataat gccacttact tctgatattt 783840 tgataacaaa aagcatgggt ttgttcaacg taaatgatat accctcaaaa tgttaatttt 783900 ctgactactg aaaataaaat tggatttcct agaagtgact gtaggttgga ataaaacatt 783960 tagtagatgt ctgagaatgt tataatcata ggatagttat gttgatattt ttgtaattaa 784020 taaaatacat tttaaaagtc ccatttagaa gaaataagga ctccatgaaa ctctaggtca 784080 ttagtagtga gctgggtata tgattgtgtt tcaaaatgac tgttctgatc tgactgtaga 784140 gtatttgtca taaatgccta agtgaatgtt aatgagttat ttaccatgta ctaatgttaa 784200 ctttctttcc ccagatgcaa agagtttagc tgaaatgctc atgaggtaag aacaagacct 784260 agcaccccag atatcatgtt tgaaagaaca atttccaact tgccttgatg atttctattt 784320 ttttaataat ggcagtctga aattgataat gtcttttctt tttagaaaaa actgtaattt 784380 cctatacatt ccaaaatatc catgtaatgc ctagctgaag gtgtagatga aaatgatgta 784440 tttgtagaca tgccacaggt agttgtcttg ttggctggac acaaccaata gaaggcttcc 784500 cattagcctg ggaacagaag cacgtaaaga ggaagtagct ttagttttgc cttcatctaa 784560 atttactact ggtgaggtca agccttcttt ctaacagaat aatccaagtt aaaagaaaag 784620 cacaaaagga atgtgctatg ccccatgctc ttcaaaggct ctgtgtctcc atcagcaccc 784680 tccaccaggg cacccttcag ctcctcttac cactgtctgt tcactgtcta ttctggtcct 784740 ggaagtcaca gccttcatag ttcatcctcg tgttaggagt agccagcaca gtagttgccc 784800 cattcataac cgtggagggg atgaatgaag agtggttatt gaatgagtac gagaatgttc 784860 acaactgtgg aagacagaaa tgcatccttc acagctttcc tttcacacgt ccacaggctt 784920 gtgattggca aagctgtgac aagtgtgtta ctttcacgtc cccaaactct attttccacc 784980 cagtccccct cttcaaatgt tcagttttct tgtgctgtcc aaccttttta ctctgtaaat 785040 actagaacac tctgatatga agcatttaca cgtatggatt aattgcctga tgtgttacct 785100 caccctgata tttgcatttt aggcctttca tattgcaatg attacatgaa aagtgaaaaa 785160 ggaaaatcag agtctaggaa ataagtaggg aaaatgtcaa ggactccgat agtgaactca 785220 acattgccag tttaggatga tttacgtggg agagagaggg tggatctagg acctcttccc 785280 actcccatca ccaacacatt tgcctgtgac ttcctcctcc atctatacat ataaaattag 785340 tactctttgt tatttaaaaa cttcccatgt tccatatcac taatatcttt gaagaccgaa 785400 ggcagtagta gaatgccatt ggcacacaga ttccatccta cagacatttt gtttggccat 785460 accgtatttc aaaacaatgt gaatcgtagg taaaacaatg atatgaagga taagtctttt 785520 cctttttctt tttttttttt ttttgggaca gagttttgct cttgtcgccc aggctggagt 785580 gcaatggtgc ggtcttggct cactgcaacc tccgcctcag aggttcaagc gattttcctg 785640 cctcagcctc ccgaggagcc acgattacag gcgcccgcca ccatgcctgg ctgatttttg 785700 tatttttagt agagacagag tttcaccatg ttggccaggc tggtctcgaa ctcctgacct 785760 gaggcaattc tcccgcctca gcctcccaaa atgctgggat tacaggcatg agccaccacg 785820 gaaggataac tctaaaatac atttgttgtg actgatctga tgaatgttgg tgccatctgc 785880 caagattagg aagatagagg caggctatgg acttttgatt tttttggaag gtaggttggg 785940 aggaggtatt gatgggaatg aaaagaccta tttgggtcat gttgaatttg ggattatttt 786000 taaggcatcc agaggaaatg tcagatagac aactggtagc agaaatctgg agctcagagg 786060 aaaagcaaag atgcaaattc cctgtacagt atctccttca taaggggtac ttcatcacat 786120 ttccaggaga agattacaga aattgcatga gatgccttca gcccgtgctt tttgtttatg 786180 tgacatttat gggtcacagg gaacacatcc aaacacacat gcacttgtgt taagcagatc 786240 tgataaaaca aagatctgct taacacaaag aagctggaaa acaaagaagt cagagtcaca 786300 tgacttgtaa taactgatct acctaataaa agaaattgtc aaaggtagac tttaaaaata 786360 tgaattagtt gatgacattt aaaatgagga gatttcacat aaaatttggc tttctgattt 786420 ctcttgaaaa tgccctggcc atactagcac cgcggaggtg ataatggtgc ctggaggtag 786480 gcacagtagc cctttagaat ggcgtgagtt tgctcaccac cgcagccccc acccctaccc 786540 caccccgggc ctgcttcacc agtccgtaca ctgagcaggg ctccttcagc cctccagaga 786600 gcttctcctc ccctcaactg tgctctgcac aacctaccct ggccccctcc cctatctact 786660 cccaaactgt aaatcatgcc tttgtccaga ggctgtgaaa ctgcgggcta tattttctga 786720 catgttcaac atttgctcaa ttaggatgat ttgctttttc tcttctcctc atattctaga 786780 gtacattcct actccttctc cctagcctct gagaaagaca ttagcaagca tcctctatga 786840 atagggcagt tgctgtggtt gcaagaccat ctgttgataa gaggaggaat taattatggt 786900 cttcctattg ccagttacca gcatgaatta ggaagagtaa agccagtaat cacaaccact 786960 tatgatagtt acagtggttt tccttcaaat ggtcaaagtg attgaaaagg aagagaattt 787020 tcaagctcct ccaataggtg gatttgtatg ggattaattt agaagtaaaa gcaaagcttt 787080 tacccatgaa aggttggttc aatctaagtt cggcaggtga atgggccaag caaacaaaaa 787140 cctcattacc taactggtca atttagaatc aaccatattt ggacatggcc cagggggtcc 787200 agacaaatca tgtccactgg cagagagaaa gatactgaac agctacccct ggtctgtgtt 787260 gctgttttct ctagaagtca aaggaactgg cagcctggta cagtgagaat acgaaccaca 787320 agtctgtgct ctaggcccca tgtggccata agctggtttt cagatcttag taggtcattt 787380 taccgctttg ttttccttac ctaaaaaata aaaataaaat aaaaaattca acattgtttc 787440 tagctttatc actccacatt ctgtgttcta aatggatgta acatttattt ttcaaccatt 787500 ttctaccaag aagtatctgc gtatttcagg gagattagct gagggccagg ccaggaaggc 787560 agattggaca gcagaacata cccactcagt ctaggtcccc agggattcct ggcctggcag 787620 catcacccat tgctgggctt catgctccta gatatccacc tgtttcaccc atgcacatca 787680 ccccagagaa gagagactgc atccctcaca cccagacaga aagattgtcc ttttatattt 787740 ttatgtaaga tttttatttt taaaaaacag ccttctaaga ggtgtttgct ccaaagagat 787800 aactgtatac tgtagagagc taacatataa tgtttaaggt ccaggaatca gcattagcga 787860 gtgagttggg tgtaagcaga aaaaggttca aattagttca gcttttttga tgttcatatt 787920 tttgtgcaca taataaaaaa tctctaccct agtgttataa tgagctatgc tcctaatagt 787980 ccaatagtca ttgtacattt aaggaatgtt ctgtgtcata tttgggagga tgatggacta 788040 ttaagacttt gaagagtggc agtggctgca aataattgat tggctaagct gggaaattct 788100 ctgccctatg aaaccgtctc tgctctcctc ttcttctcat tttattcaaa caaccagatg 788160 gcaaataaat ggatggttga agattatagc tcaataataa ctaatatgtt tagcatgatc 788220 ctatgccatg caaaaaagat gcaatttttg cttccacagt gaaaacattt ggactgtttt 788280 tccaggttgc aaatgaggtt tgttcaaatc acttttttaa ggtttgctgc cattctaatg 788340 accaattgtt atcatttttg aggttaacag aacacagagt gataaatata aatgtaacaa 788400 tagattgtca aaagtgacag caaatattaa gtaatgaaat aacttagttg gaatccagtg 788460 accttttaga atgagaagga tattattgcc tcaaaacaaa gtcttgggga catctcactc 788520 agctcacgtt gtgccctcaa aataaatcaa tgtgaggatt tacttcacag atatttattg 788580 agcacctact ttggccatat actgttctaa gttctaggga gacacaggaa acagagcagg 788640 tgaagaaaac cctggtggag catattttcc agtgagagag gcagataatg gataagataa 788700 atcaactaag tatatgctag agagtaataa gtgccaagca gacaaaatta aacagagaat 788760 ggggacagga cacagaagac gtccccatcg cagggccagc ctggctccac tggaaagatg 788820 atggcatctg agtccagcct tgcaacaagg gagccagtat gtgggttttg ggggtagcag 788880 gggaagtgtg ttctaaacaa cgggaacagc caagtgcaaa gagaaagaag aactgtgagt 788940 ccggccaggc gcagtggctc acacctgtaa tcccagcact ttgggaggct gaggcgggtg 789000 gatcacgagg tcaggagatt gagaccattc tggctaacag ggcgaaaccc ggtctctact 789060 aaaaatacaa aaaagccaga catggtggtg ggcacctgta gtcccagcta ctcgggaggc 789120 tgaggaagga gaatggtgtg aacctgggag gcggagcttg cagtgagctg agatcgcgcc 789180 actgcactcc agcctgggca acagagcaag agtccatctc aaaaaaaaaa aaaaaaaaaa 789240 gactgcagtg aactgtgatt gcatcactgc actccagcct gggcgacaga gcaagaccct 789300 gtctctaaaa acaattagct tctgaatctc aaggcttgtt gggccgtttt cttatagtct 789360 tctgaggagg aagaatttac ctccagcctt ggttgtcctg gttcgcagag ttgaatcaag 789420 ttctaaatct tggtgccagc cagtcgcagt ggttcacagc cattatttag cctgcttcct 789480 gtggcaatct ggtagcagac cccttattgt tgtttaagta tagcctgcac ttggtgttca 789540 tcgctattta atagagcagc cgctgactgc ctcataacta ttcatgaaga gcagaaggaa 789600 ctagctcaca cttctatttt tggtgcaagg acaagctcaa gtccctagtg aggtttctaa 789660 acagatcttt gggatattca cagaggagta gttccccata tgtttttgtg gaaatatagc 789720 ttgtctaagc atgccgtaaa tgcagccccc caagtaacca aaatgctcct ccttttattt 789780 gattatttga attttttcat tactctcttt ttaacaaaat caacgaatga caagttagtt 789840 aagtcagtaa tttgaaagag cttggagacc atgtgaaaag tcaggacaaa acgtttgaat 789900 ttgggctctg cataattagc atgatgtagg tacatagccc agttccttat ctgcagagca 789960 agcaatctgg ttcaagatca agtcctaagt aggaatgttg cacctttcag aagttgtctt 790020 tttcatggga taatttgctt ttactcaaac gaggagtata catggatctc atcaggcaaa 790080 catctaaggg ggtacttgag tgaccttcac tttgggataa ttaaagttct gtccaccact 790140 tggtttaaga gtggatgagt cctcattaac aaggaaggat cggtggaggc acagccctgg 790200 gactcggggt aaatggctcg gttagagggg aaagcattta aaatgtagca ttgagtattc 790260 ctattttggt ctccactaaa agtaacacag aggtaaacca ttattgagtt aactaggctc 790320 cagaaatctt tctcaaaacc agtgttaaca acaattgagc tggattgatg gatgccatag 790380 attatgccat tgattggatt atccaagtga ctgctgcttc ttagaggatg cttcagtaaa 790440 tactatttga acatctagta aagtcttatt attctgtaaa gactgaacaa ccacccttct 790500 aatgtggatt gctaattaaa gtctttattg acttttttag atttttgtgc aacgtggagt 790560 ttttttttta actgcaggct ataactgaat ccgattctac catgcagttt tactacttat 790620 tttcatttac ttttagagaa cagctcactc taagagtaat cttctgatac acaaattttg 790680 agattaaatt atgatagtaa ttgctttttt tccattctaa aatgtactat cagttaggaa 790740 aactaacgtc agggaagcta acaaggtttg tgatttgctt ctagaacaaa aataaaatga 790800 caccagatat aaatacaaat ccattagtaa aactcccatc cgacaaacag ctggtgcacg 790860 tgctttttcc ctcaccatct ttggaatatc tggtgcttta ttcctcacca tcactggaat 790920 atctcacatc tgacaaatga aaatgctgtt ggtttttaat tgcttttcat ttgtttcatt 790980 tagcatttac acaagaaatg agaactttct aaagattcta ttggtagata tagagccaat 791040 ctctattgac aatttgtatt ttctgaaact ctccagccag ctgaaattta atattaataa 791100 ataaataaca tttgaatgaa ggaaacgttt tcatagtatg tacgttttct gttcccctcc 791160 tcacaaggta tttgtatatt tagacaataa actaagttgg tatacaggtg catgttggta 791220 gaatgttaac actgaactgg atttgttaat gcattacccc attttattcc cagtaagaat 791280 acccggactt cagatacgtt aagcaagcaa cagcagaccc tgcgaatgca catcgacata 791340 cccagggctc agcttttgat tgaagagaga gacacgatgg agaccattgg taagctgccc 791400 tatttgccac tttacacaaa gtggctgcca cagccatgcc ttctcaatcc aaaccccagg 791460 atgtgggaaa tattagacag gagagcgtct tgaaggctac gtgagtacca aagctagaag 791520 gtagagaatt gttcttgtga agaagaatca gtaccagcaa atgtgcagaa aatttgactt 791580 atatatacca ccatatatgc caatatgcca gtcagttcca ggcatttggg acagaaatcc 791640 ctcagctctg atccatttgg gatctttcca ggggaggcta cggatgccac tccaaggaat 791700 aaacatctgt aatcgactac acatcaatcc agaaggcctg cactctaaag ccccaggttg 791760 aaaatccact ccgtgccccc ctcatcaact ctgataatgc aagccttcat taaataaaac 791820 ttttaaactg tacttaacac ttaaacaaac acatgtcttt gtacagggta tcttccccca 791880 caccagtgcc ccagaaacat cctgcagctg tttccccagc agcactttgg gaaaaacacc 791940 agggccctag ttttagggtt tcagaacagc caccctgagg ttttctggct tgttcaacca 792000 gaacccaggt atcttcactc ttcccagcct ctttccacct gaagtccatt accccacact 792060 gcctgcctcg attattctat ttattccgga gtgaaatacc ttatatttcc tttccagtaa 792120 taatgagaag aatagctaac atgtattgag aattctgtaa atgtcacata gtttttataa 792180 gcacttcgtg tgcattactt aatttaacct ttcaaccaac atatgaaaga agtcttgctt 792240 ttgtaaccaa gatgtagaga ggtctgtgta gctttccaag gtcacagaga caggcgcaga 792300 accaggttcc ccacctggcc acactcaccg ccatgctgtc tgtctccaat gacagctagc 792360 acagcagcag gccacctgct tccacaccaa caggctgctt ccaagaaacc ctcaaccaga 792420 agttatccaa gcttttgagt gcccatggaa acaccctgag gcaggctccg aggctgcctc 792480 ttttcaaacc tggctatgtt tgttttggaa ggtgtttgct ggcatgagtc ccaggacaac 792540 cctttcttgt ggtctggata aactgcctga ctctcagcac atagcccagc tgcctcctgc 792600 cgggaaggca gtggtaagag accaggtggg cagaacacct gctccatcaa ccatcaccct 792660 tctgctgccc cacccaccac tggagacatc ttgacctaat ggctcctaaa ttctaaggcc 792720 tgggttctcc tggctgaagt cacatttggt ccaggcatag cagcacttaa agattggtca 792780 agtgcaaagt ggctcttgat cagctaactt cagtgaaaca cttcagttaa accatgtatg 792840 tgaggtggca ctacctgccc taaagtacac aagattttat tagcttgctt gtatcaggac 792900 aagggataag ctactatgtt ttgcttttga ttatcttttt ttgggaaagg ggaaggtata 792960 cctggaatct cttttgtttc acccagtaga ttgggcatta aaactgaaaa tttcctttga 793020 aaaaatttca aaaattagaa tgtaattcct ttgaccatat aattttataa gccatttata 793080 tgcattattt aatttaaccc ttccagccaa cataggaaaa gtttcttttg taactgagac 793140 acagagaggt tacatagttt gtggaggtca ccatggttat ataacacgtt acaatatttg 793200 ctaaatgcgt ctcactagac aataatccta catatggcta tgaaaataga tagctaggca 793260 gatgccatga gtggtctatg gccttccaag agctggtcac tggggggctt aacaccagag 793320 gaagcctgcc agtcatttcc atttgtaaat atgaccgttc gccagagatc catcccagtc 793380 catgcaggat catgtatcag caagagccct tgacctcctt gtgatgcctg acaatgggtc 793440 gatggcattt tctaattact gggaagtgga actgtggtgc ttcaaaatgc tctgggctct 793500 gaccacaaga atccaatatt acagtgacat taatttccag ctagaatgaa tggttaacct 793560 catgatcaga caggcgccca aaattttcca tgaaaagtgt gtaacctagc cccgcagatc 793620 atctggtgtg atctaaaagg gcctgcctgc tagaaactgt gacatatccc atcattaatg 793680 aaaaacaaat gtagacacgg agcctctcgt gctgggtcca gttgtaggaa gctgtctctg 793740 tggaagagcc accctctttg aggagtcgag tgaccgccac ggggccggac ctccaagcca 793800 agcccaggcg cctgctgtgg tgccaacctc accgcaccat gcgctgggat actcacagac 793860 atcttggcag cctttcctct atttctctgc caggaaattt tattctaact ttgagaggct 793920 ttcctttcct gccagagact gagtaattgg attttgtaag gttcattctg ttcagagcct 793980 tttttgggca cagaagtcga gctgtgttgt ttacgacttt cgcatccctg ttgcagtgtc 794040 agggcagggc tgcagtatgg tccctgctga ctgataaact cttagcaaca gcatcctggg 794100 ctgcaatctt tgaaaattta tgaaaaatct gtatatccta gccaaagtct cccttggagt 794160 aaaaaagctt tttaaaaagt atgaaacata tcacaaggta gtaatgagaa tcctggccca 794220 ccaaataatg acccagctca aacagcagct cctgctccaa gcactaagat gcccagaacc 794280 catccaaacc caggctcctg cctcgctcac cttcaagtgc ccacggcagt aggacttggg 794340 aagtctgaca agtgaatcat gtaggagaag tcagttaatg gatgttctag agtgcttaaa 794400 gcttacagga ggtgggaaga aaaggaacat accttgagtc ctttaaaata gagcaatcaa 794460 taagctctga agactggcat gttttcttct cttttatttc ccctccaaac attagccaag 794520 ttcagaatga gagcaaacct cagtagagag aactgtagtg gcgattttct agtcctgcaa 794580 acagagcttc ccagcagcca aagggacctg tcttcattga cagcctcatc actggtgagg 794640 gggctggcat cgcagatgat gtctcagaga agcttttgac aaacacataa atccagagtt 794700 caaatcaatg ttagcttaat gaaaagccaa gcccaaagag aaaagagagc tccttctctg 794760 catagtcatg gttcttctta gctcattgct cccaaagcca acccctagga agaagcttct 794820 attcctagca ctctagagta atgctaattc agtgcttgaa ttttcaatca tttttgtcac 794880 tttagatggg gctattattg tggttgtcat taacaataac acaagtgcct caggagagaa 794940 aaggccaggg agtggttgga agggagataa acgtgtttgg ctttctgtgt tcctgccatc 795000 ctgtagatga tcgctccacg gttctgttga cggatgctga ctttggagag gcagctaagc 795060 agaagtccct gacggtcact cacacggtcc attaccaatc ggtgtctcag gccactgggc 795120 ccttagtgga tgtttcagac gctcggccgg gaacgagtga gtggtcaaca atgcttaaaa 795180 tgtgtgggtg ttaacaatgc tgaaaacata gtaatgttct ttctctctca aatgaaaatg 795240 tgtggctttt catacctatg cctgagaaac aaatgggtat aataacatcc ctaattggga 795300 taatgagctg ttattgatgg atcttggcta ttattatgtc agttgaatta ctgttagtat 795360 tggttactat aaaaagtgct agaaatttca ggtacatgta tttatttttt taatttaagc 795420 aacacagaaa aggaaaaaag taatctactt tagtgtgtat ctgctgtatg ccagtattgg 795480 gatagaacga tgatgtcatg cacgttatct ttgcaacaat cctgtaagat acctactcgt 795540 gaagcaggta tcatagcctc tattctgcag atgagaaaac tgcagcctca gataaattat 795600 gcaaacagta taaagttgca cacataagta gtaaaaccaa gattcagaaa cagacccatc 795660 tatccccaaa gcttatgctt ttgcccctga acacactgtt tgagaaaaat tataattcta 795720 gttaatgtga agattatgtt ggattttgtt attaatattt gcatccataa tatatggaaa 795780 ttaattactg caatgaaggt gaatccccta atatgtatct agagcttatt aattagatac 795840 tcttatttct tcataattgg aatcgttcct aaatctcttt aaagactgag aaattgatgt 795900 cctgattatt atcattttgg aaactttgac gtctagcttt caaatctcta atcaatttct 795960 ttgcaaaaat ttacattctt agaatagtgt gttattatta gaaaaataac tattataatg 796020 ttaaaagcta ttcttcataa atcctagctt gggaagcatt tgcgaaatgc agtgagcttt 796080 atgaagtaaa cccattgcct acgaaataac attgtaatat acagaaaaca gtttcagcag 796140 gcattgaaat tcatttaaaa aatgttttca agaatattct acattctaaa gaagtctttt 796200 acctcttcct tttgtctaat cttcttaccg cctttcttct ttgatcacat taatacattc 796260 tgaagacata aacgggatat gagtgggaat tagctttgca aaggggtgtg tgccagagcc 796320 ttgctcttaa aaaatgatcc agactgggcg cagtggctca atcccagcac tttgggaggc 796380 cgaggcggtc ggatcacgag gtcaggagat tgagaccatc ctggctaaca tggtgaaacc 796440 tcgtctctac taaaaataag aaaaattagc cggcctggtg gcgggcacct gtagtcccag 796500 ctactcagaa ggccgaggca ggagaatggc gtgaacctgg gaggcagagc ttgcagtgag 796560 ctgagatcac gccactgcac tccagcctgg acgacagagc gagactctgt ctccaaaaaa 796620 aaaaaagatt caagggcttt gacatctctt cagccgttgg cttctccctt gtgaactgcc 796680 tggtgtggct tgctgctact ccaagacact gctccaatgg gtttaagagc cacttttttg 796740 ctgctaaatc agaaaaagtt acagatattg aaaggattag atttttagag tgatgcagca 796800 ttggcttcag cattctgttg gaaacggtgg cagaagagca ggcaaaagag acaacagagc 796860 agatgccctg ggtctcgttc tccaccttta catgcatcag aatcacctgg tgcctattta 796920 aatatcaatt ccaggcctcc acccagagat tctggcctag gaatccgcat ggtaacagac 796980 accctgggtg attctgatgc tggccgtttg gaccccacat tgagaaacac tgccccaagg 797040 gttagaaatg tttcctgcat gtaacgcagc agggcaggac ccctccggca catcagttct 797100 tcctgccagg taaaaagcaa catgcatttc tgcttccctg tcaatggtca gctagcagcc 797160 gagaatgcat aaagctagtc ataaatagtt aagacaggag aagcagcagc ccaaaacaaa 797220 agcactggca accttccagc ttcatggtca gccccagaat aatggggaag ttgatttgtt 797280 ggcatgtaaa atatcaacag agacatgaac cggagtcaca gcagatactg taaaccagtg 797340 gtcagcgagt gccaggcagg acgcacatgg gagggacgtg tgtgtatctc atggctataa 797400 agttggaagc agggctggga atgttaatgc gttcattcag cactcaaaag tatttattca 797460 ggtttcactt tacgtatatg gctcagtgct gtatgatgga gatacaccat gagtaagatg 797520 caaaaagaca ttcatttcat cctagtcagg gggcagacat tagacatgga actaaagtag 797580 ttttcatttc tcagtaagtc ctagacagaa agagaatgaa gccatggtga gtcagcgggc 797640 gtgtggagca gtgggagggg ctctcttggg tccaagtcat tcaggaggac ttccagtgag 797700 gggaagacat gaaacaagat cagagtcaca gcaggagcag agggggcagc agggaaaagc 797760 tcccaaggtt ccccgcatga tgaggatgga agtggcactg gagcacagtg aaaggcaggg 797820 aaaaggtgag acagagaaac agctgtcctc atctttcagg gtcccctaag ccagtgcctg 797880 gcaggtgcat ttcattctga gagtgctgag atgctgtccc tggggcttag cctgatgatc 797940 acagggaaac actatagctt atagaacaat gtttctgtcc tttgtgctga atttcactaa 798000 atgatgttta ccaacatcaa gcaaatctac tcaaatgcat gcatcagtct ctggttcccc 798060 cctcactctc caaattgagc gtattaattt agcatttgca gaaccctctg tattagtaaa 798120 agatctgctg gatcattttt ttcattaaat cttcctcaaa aaccacagtg tgagggactg 798180 acaacactcc gtgttttatt tagagttaga aatggtaggt gactggcccc acagtgggtt 798240 caagagtctg aaacccatga actttctgaa gcacagtccc ccactagctt cttgcaccag 798300 agcttctcac ctctgcccag gtgtttatac ctctgtgaat tccatggagc cggttcttct 798360 caccacagtt tggcatactt gcagagaatc atttgtattc tctattttct cagctagaga 798420 acacatcgtg attctatttt gtatgttagg actgtgttgt cattgcaaga attctttatt 798480 tttaagaaaa gcatctaaaa catgttgctt gcataccaga atgactgcat tgtagaagtt 798540 atgtttctag gcattttatt agtttgccag agggttgcaa cagattctta tgaggatgga 798600 agaaatcata acaatttgct atttatctct gtcagtagtg aaaacacatc ccttggctgg 798660 ttctgctgca ctgattactt ctctgtcttt cctgtggatt ataatacact ggaaaactag 798720 gactctatcc atgtcctcat ccccatacca gccacagtgt ctgacacagg catgtagtgg 798780 ataaatacca atcagccatc aagttctgag atcagaacaa tgggaatgga aaagaaaaga 798840 cattgagtca tgtttgctgc ataggaatca tgggcacggc cagctgtgcc tgtgccatgt 798900 gcccggagca cttgggcaca ttaatctcat ttaaacttca ggacagctct taacgtgggt 798960 gatgacatca cctagtctca gagactaggg gattagtcag gtctgtctga caaggtcact 799020 tggccagcga cacagccagg gagtagtgaa tatgaacttc cagcccaggc agcctaattc 799080 caaagctctc actctcagtc attctacatg gcctttaggt agagatacta catatagaat 799140 atgtagagac taaagaatag acttcacatg tacgcacatt caatgacaag agcttacaac 799200 atggacttga atctttattg ctgagacttt gaaagaaaaa atgccctctg ttacccagga 799260 tgggactagc agtggccctg agggaaatac ctggggtggg tgaggtgcat ccagtggtcc 799320 aggatgtaat aagtgctaga taaatatttt ttagttacat gagggagtgt tcagatctcc 799380 cagtttcatc ctctctctga gacaactagt aaattcgtta tgtaaagctg gacctccaca 799440 actgcaagat atggaaacca atggcacaga tgaaagcaga ttaataccat gatcacagta 799500 cgcatgacat gttctgtaac ctattatatt atctacaaaa tcctctctca tcccaaactc 799560 aggataatta aaataatctg attcaatggg cagaagctta attagggttc aaaccccatg 799620 ttgaaaggcc atgagctatt tatatcctgt gccctccaac tcatgggctg ctgagcaggc 799680 atgaagctta atcaccgagt tttatttata ttagaatgct gggagcctaa caaaatactt 799740 tccatgaagg agcagtaaat cccagcgttt atttgctcag tagatgagct agtaagttac 799800 acaaaaaagg cttcctgtgg aatccaagta aaaattatat tttagctgct atcttagtca 799860 ttatcataca gcagagttca gttcaggtac aaaacaatgg ctccaaaaac caaattatta 799920 aaaaataaat gtgtcaaata ccccagtatt ctacatactg aggcaatttt gaccctagga 799980 tgcctgccta gcgcagtaca gaactgaggg ctgtggttta aggaaactaa tatcatgacc 800040 taaattttca acattatcag gccaccagta aaactgtcct catctagaaa aaaagagatt 800100 atgaacaaaa ttaacttgaa aagagaccag gctttgaatc aaggctgcat gtgcgacttt 800160 cccatggaat tttccaagta gggtgatctc aatgaggaaa ggggctatga cagtgaagat 800220 ctttgcccca ccattggaga gtgagctcaa gcagaagaaa tgagggtcaa ggtttggggg 800280 attggaggaa atgactgtat ccttgaagtg ggactagcaa actatacccc ccaaccaccc 800340 cccaacttcc atgccagaag taaacctgct cagaatgagc tacaacagtt gtagttgcaa 800400 gaaacttaaa gaagaataaa aatgagaatt ttcaaaactt atgtaaggga ctgggtaatt 800460 ttctggaaaa gactcattag catttaaata acaagcttca cttatttaag ctccacttat 800520 caagtcgata gtgcctggaa gacatttagc ctcttcccca tcataatgtt tttctgtctt 800580 tttgagggcc tctttcctag catttcggtg aagaaaccca attatcattc atacctggtt 800640 gtgtagagct ccaacataac tcatttacat tctcatcaag gacaaaaaaa atctaatgaa 800700 gtcttccgtg gaattgtgca agtaagggat gaaatgtgtc ttaaaatcaa tgccccagag 800760 aatatttacc aagattgagt attctgatga tttaggagat cttaaaatct atctctttgg 800820 ctgccatctt aacgcacctc tccagcgaca cagaatgata gattagattc aaagtcgaat 800880 taactagaaa cttgcagtga ggaaatctcc cgtttaaaaa caaagtcatt gcaccttccc 800940 agtgttagcc tttcacattc caacatggaa ttataagcaa gccaaggtca tgtagacaca 801000 gcactaggaa acttagacac tcaggatttg gccatatgtg gtcaagtaac aggcgttatc 801060 tgaactgaaa aggcagaagg tttgggttat agttttatca cgtaacagct atgtcacttc 801120 tctctgagct tccattgcct tcataaagtg accctaggtc tatgaattcc ttcagaaaac 801180 tctgtatgtc agggattatt gtaggctcta tgaatggatc cacagaggga taccattgcc 801240 cctgccctgg agacactgcc aggctcatga aagcacataa ataaatcggt gcaataacat 801300 tacaggccgg ccctgtcagt tttgctcctt tgaaacttcg tgagagccca acagtgaata 801360 cagtctgctg ggtttagaag tggccagacc atactgaaat ataactgtat caaactgctc 801420 tttgagaagc agagaattca aaggtagaaa agacccatct aggaccttaa gctgtctcca 801480 ggctggagcc ccagaaaaat cattccaggt aactgaacct ctctcatttt ccacagaatt 801540 ccagaagagg cgatgttgta gcccattctg gtacctgaca gtctctgctg gtggaacatc 801600 cttcttctta cctcaccaaa gggttgagct aagaactccg tccaccccat agacttgctg 801660 cctttggttc cagatttaga gaaaatgaaa cccatctggc accagcttaa ccctttgttc 801720 tccatattaa ataacccaag ttgtctctgt taaagttagg acaattctat tgaagagatg 801780 tgctatcata ggcaaggcct taaggagagt tgggacataa aaatatggtc cctctgcttt 801840 aggagctttc aacttaatga ataaaacagt catcattaaa acaatgagta gtaatatgag 801900 aaacaaaaat acaggcaaca tctgtattaa tttcctagag ctgttttaac gtagtaccac 801960 caaatgggtg gcttcacagc acagaaatgt atttgcttgc agctgtagca ctccagtctc 802020 cacctgcatc atcccatggc cctctcccct cctgtgtctg tgtcctcttc ttaaaaggac 802080 accagtcaca gtggattaag ggccaaccct attccaatat gaccttgtct tagctaattt 802140 catctgtgat gaccttattt ccaaaccaga tcacacattc tgaggtcctg ggggttagga 802200 catgaacatg tcttttgggg ggacgtgatt cacgcataac aacacctaag gatgtagaaa 802260 ggaggtcatg ttagaacaca ctgggctgag cttccttgtt ttacagaata tgacgatgcc 802320 caggaagttt aaatgatgtg catcgggtca taacattatt ttttgtacta tcatccattt 802380 aattgcagtt gcaaacatcg taaccaaagt acctctctca agtcattctc tagcacagta 802440 attggtttca ttttctttat aatcttcatc actgtttgaa attttcttgt tttgtcctgt 802500 aattgttgtc agtctcccct cattccattt ctagctttta atgttagaag ggtcataaca 802560 ttattaaagg ccaagagcaa gactcaaata tgtaacttct gaatccaagt agggtgttct 802620 tttccctgca gggctgatta aacacgtaag tatcagatga aggtttcaag ccataaagga 802680 aagggaaagt atcctctgca caggagaagt caaggaagtt ttcctggagg gcgtgggcga 802740 gtcggcagtg ctgggtgggt ggcactgacc tctacgcttg ctctcagctg accacactcc 802800 tgcagacaaa ggcagacatg attcttggct cttcacagat cccaccacca ggaggaatgc 802860 caaggctggg cccacagcga gaaaccgcta tgccagccag tggaccctca accgacccca 802920 ccccaccatc tcagcacaca ccctcaccac agactggagg ctgccaacac ccagggctgc 802980 aggatcagta gacaaagaga gcgacagtta cagcgtcagc ccctcgcaag acacaggtag 803040 gccctgacgc tgcctcctcc gtccctgggg accagcacgg cccccgcacc ttgagcttca 803100 tgggctcctt ggggagggga gagagggctt cctccctctt acttatgttc ttttgaaggt 803160 cactttcaaa ttgttacgcg gtttatctaa cagttactaa tacaactgca cagcctttac 803220 tccacacagg gcaaaacaga gccaaactgc atctattctg caggtgtcct gaatcttaga 803280 cccaagctta tttctccatt tagttcctac cccactggga gaaatagaga catttttaaa 803340 ttttcacccc cgtgattgca gtaattgctg attacactct gagggcgtct gacccattac 803400 catctccaag attaagacac agcacttgaa gttacatgat gaggtcatag caccctctat 803460 agggaacaca ggctgatccg tttgacaatt aaacaggggt tggttataag gtaagtcatc 803520 cagtctatgc catcaaccac caagttttca cttcagagag aagacaggcc ctaagaatag 803580 caccgggttg cccaccaccc cctcttaaat tttgaaaaga aattacatct gaatctaata 803640 gctgtaggaa attttaatac tcatttttct tttgttcttg atgatatact tcaaaaacag 803700 tgttccagag gaggatcatc gccatgtgaa tttattttta aggctgtgat ttctcttaga 803760 agagtctcag agttccacac agaggagacc ctaaaacttt ttagtgcatt tgaaacgcag 803820 acatctccct gaccaagatg gcgtggccca gctcaaaggc atgtgggcac cagtttttgt 803880 cctgatggtt ttctagtccc cataaagggt aatcacaaca gaagacgcat cccaggggtc 803940 gggggccatt ctggcttgtg gccaatttcc gtgcaacatg acatctttat ttctaaatat 804000 catcacatct tccttcctga gctgaggccc cagaagctga actgcagctc aaatcattca 804060 tgccaattaa agagtctcta gggcatagat ccatttgcag gttggagcag agagggggct 804120 gctgcctggc tcctactgtt ttcactaaaa gcaggatttt ttttaaaggg aaggcgttat 804180 ttatttatgg aaatgtccca agctgggaca tctgactaca gcaatttggt tgcaacaaag 804240 cttcccttaa ccggatctgc tgagacttgt gaagctggcc tcagagtgcc taaggcagga 804300 gcctccgcca aggagccaga actcctacca ggtcccacca tgatctggaa gaaaacagcc 804360 ccaagccagg aagggccatg ccgttggttc agacttctga tggtgagtcg tccgtcttgt 804420 ttttctcttt cctggtgtag atcgagcaag aagcagcatg gtctccacag aaagtgcctc 804480 ctccacttac gaagaactgg ccagggccta cgaacacgcc aagatggaag agcaactgag 804540 gcacgccaag ttcaccatca cggagtgctt catatcagac acgtcatcgg agcagttgac 804600 ggcagggaca aatgagtaca cggacagtct gacctccagc accccttccg aatcgggaat 804660 ctgcaggttc actgcatctc cccccaaacc tcaggatgga ggaagagtaa tgaatatggc 804720 agttccaaag gcacatcggc caggtaggtg agcaaggcca cctgggggcc gtcgcttagg 804780 gaagtgcacc ttcctggtcc tccctcatct gctgtgaaag cccttctcag tgttcagacc 804840 aaatgggtgc tctgtttatg gatggctgca taacaaacca tcccaaagtt cactggatta 804900 aaactacagc agtcacttac tttgtttatg aatctgaaat ttgggcggga cctagtgagg 804960 gtaccatgct gcagaggctc tcctggggct ggggatccac ttccaaagtg gctcaccgac 805020 ctggctgtgt tctccctgtg ctggcctctc cacaaggtgc tttagcttcc tcacagcatg 805080 gtggctgggt tctagcagca aatggtccaa gatacagtct gtggaaatag ccagtttcct 805140 taggttgggc ctggaaactg acacagctat catttctgtc atattctatt gggcaagcag 805200 tcacagagcc caagaaaccc tgattccaga gaaagaggcc cccactgctt gatgagaaga 805260 ctgtcaaaaa tgtgagggct gtattttaaa actgccacac tgagggcttc tgaaagggga 805320 gaggtcttac tatatagtca gtgtttggga cttggcctca ctgaattaca caaggtgatg 805380 gtaactggct aacattaagt cagccagcag tttggtcttc aacttgaaca cctgtgaatc 805440 gtccgggttg tgaaagctgc aaattttgag gtcagcaagg catggcagat aatagaatgc 805500 agaggctaga gaacagggtc aaaggagcga ggcggacatg ggccatttca gggttcacta 805560 ctgtctaaaa gaaaagactc tagcaaggcc ctgccaactg atcgcaagtg gaaatggggt 805620 cttagtatgg acttgtgttt taagagaagc cggaaaactt ggttttatat ggaaattcac 805680 agctttttag tgttggcttg gatatttgta aaccattgta cagggcaaat aaaacccatc 805740 tttaggtgga atccaaccta tggcagccaa gtgtagttct catctgaaga accacttttt 805800 ctttttcacc ctgaaatagt tgcctgtaga ctttccttca cagactgatc tatccaatct 805860 tattgaatcc agttttgttt ctcattttac ccattttcta caccactgtt ctagttccat 805920 ttcaaaaagt atcttcactt ttgaattact acaattccct tgggttttat gggacaaggc 805980 ctagctgaaa tgagctttat aaatgcataa aaatatataa aataagaata gtttatccag 806040 caaataatct tccataccag ctcaagattc atgccagcat ccaataaaga atgatggctt 806100 cctttatttt cattctgtct acctccttag gggaaaagac aagctgttat ttgtgggtgt 806160 ttttatttca actatttttt ttttttcgtg ttgttggcat ttatttgcaa ggcaaatgga 806220 gaaaaatgca ggataaatgc catgactttc tgcagctctt cagcctgaag gtgaggagga 806280 ctggagagaa gaccataagc ctgtgggcat gttgtatagg cgttctcagc ttcagttcct 806340 gcatctgtaa aatgggaatg gcgttggtga ctgtgtactg ggcttctgtt agatgcacat 806400 agcattatac aggtgaaggg gtcagcagag gaggcactca gccatgttag ccattgtttc 806460 tggcactggg ttgctagaat ccccactgtg actccagctg tactgctgac ctcctcttcc 806520 ttcttgcttt tatttttctc cagtgaccac tgaagtccta gcaggtaccc acctcaattg 806580 tgtgtcaccc agttaagtac tttatgtttc cacctgagat agcatgccgt cattttccct 806640 ttgtgtgtga tttagggcac agaatgagct tctaggttaa aagactgtcc tatttgtgca 806700 ggcctttaca taattacagg gttgaagctt gtttttgatg gcacgctgct catattgttg 806760 gattgtttct taaaaatttg acctttgctc atgatattgt gacctggacc cattagagca 806820 atggaagatc atagctaagt tactattgtc ttcatagact attcagagta aaatgatttt 806880 ataaatatag gtttgaataa tctcttaaat caatgcaagt tcaaatgtcc acaaactttg 806940 ttttgtctac cctagatgac tgcattatta ctgaacatct gatatgcttt agaaaatatt 807000 tcagcctttg gaaacctttc cgtcgctcct ttataattca actaaattca acattgggca 807060 caaaatacaa ggttgcagtt tactattctg ctaactagag cttgtgatac aattagcagc 807120 tcctagagct gtgcttttac atcacattct ttccctatat gccctcttca cgctagatga 807180 tattcgtcat gtctgtttct gtttatagtc ttccaaatct ctcaatttct tcctcctcaa 807240 ctttagagct tcttttctga tggtcctttt tttctctttc cctttttatt ttttctgtct 807300 tcagtacaaa tagttatgat ccccagactt tgaaattctc tgcaaattgc catcaagtta 807360 catgaatttg gccagactgt ggcttcagaa aaataggaaa tatgtcttag ttatcttcat 807420 acttccttct caaggtctag cagatacctg atagccaagt agttatcatg caagaattat 807480 ttttaaatga attaatagta ttgaatactc aatactacat acttaaaact ctctctctat 807540 acataaatat atatatctcc tgtgtgtgtt tataatatac acatatatgg ccagactgtg 807600 tctggcacat tagtagatgc ttcataaacc ttactgtatg aatgaatata tcatgcttgt 807660 gacaacaaaa ccaactggtt aaattggtta aaatatttca attaatagaa attatagtca 807720 aataaataca aaaggacatt taaatctact ccaactttca gtagctttaa tcaaagtgac 807780 ttattttcca ttcttttttt ttttgatttt tatttcatct gcataattta atcagttttt 807840 ccttcacata ttcaaaaacc tacattggta tttttttctg acacgtttcc cctgttagac 807900 tttagttttt cttagttcat attctttttc ttttcttttc tttattatta tactttaagt 807960 ttcagggtac atgtgcatat tgtgcaggtt agttacatat gtatacatgt gccattctgg 808020 tgcgctgcac ccactaactg gtcatctagc attaggtata tctcccagtg ctatccctcc 808080 cccctccccc caccccacta cagtccccag agtgtgatgt tccccttcct gtgtccatgt 808140 gatctcattg ttcaattccc acctatgagt gagaatatgc ggcgtttggt tttttgttct 808200 tgcgatagtt tactgagaat gatgatttcc aatttcatcc atgtccctac aaaggacatg 808260 aactcatcat ttttaatggc tgcatagtgt tccatggtgt atatgtgcca cattttctta 808320 atccagtcta tcattgttgg acatttgggt tggttccaag tctttgctat tgtgaataat 808380 gccacaataa acatatgtgt gcatgtgtct ttatagcagc atgatttata gtcctttggg 808440 tatataccca gtaatgggat ggctgggtca aatggtattt ctagttctag atccctgagg 808500 aatcgccaca ctgacttcca caatggttga actagtttac agtcccacca acagtgtaaa 808560 agtgttccta tttctccaca tcctctccag cacctgttgt ttcctgactt tttaatgatt 808620 gccattctaa ctggtgtgag atggtatctc attgtggttt tgatttgcat ttctctgatg 808680 gccagtgatg gtgagcattt tttcatgtgt ttttggctgc ataaatgtct tcttttgaga 808740 agtgtctgtt catgtccttc acccactttt cgatggggtt gtttgttttt atcttgtaaa 808800 tttgtttgag ttcattgtag attctggata ttagcccttt gtcagatgag taggttgcga 808860 aaattttctc ccattttgta ggttgcctgt tcactctgat ggtagtttct tttgctgtgc 808920 agaaactctt tagtttaatt agatcccatt tgtcaatttt ggcttttgtt gcctttgctt 808980 ttggtgtttt agacatgaag tccttaccca tgcttatgtc ctgaatggta atgcctaggt 809040 tttcttctag ggtttttatg gttttaggtc taacgtttaa gtctttaatc catcttgaat 809100 tgatttttgt ataaggtgta aggaagggat ccagtttcag ctttctacat atggctagcc 809160 agttttccca gcaccattta ttaaataggg aatcctttcc ccattgcttg tttttctcag 809220 gttggtcaaa gatcagatag ttgtagatat gcagcattat ttctgagggc tctgttctgt 809280 tccattgttc tatatctgtg ttttggtacc agtaccatgc tgttttggtt actgtagcct 809340 tgtagtatag tttgaagtca ggtagtgtga tgcctccagc ttttttcttt tggcttagga 809400 ttgccttggc aatgcgggct cttttttggt tccatatgaa ctttaaagta gtttcttcca 809460 attctgtgaa gaaaggcatt ggtagcttga tggggatggc attgaatctg taaattacct 809520 tgggcagtat ggccattttc acgatattaa ttcttcctac ccatgagcat agaatgttct 809580 tccatttgtt tgtatcctct tttatttcgt tgagcagtgg tttgtagttc tccttgaaga 809640 ggtccttcac atcccttgta agttggattc ctaggtattt tattctcttt gaagcaattg 809700 tgaatgggag ttcactcatg atttggctct ctgtttgtct gttattggtg tataagaatg 809760 cttgtgactt ttgtacattg attttgtatc ctgagacttt gctgaagttg cttatcagct 809820 taaggagatt ttgggctgag acaatggggt tttctagata tacaatcatg tcatctgcaa 809880 acagggacaa tttgacttcc tcttttccta cttgaatacc ctttatttcc ttctcctgcc 809940 taattgccct ggccagaact tccaacacta tgttgaatag gagtggtgag agagggcatc 810000 cctgtcttgt gccagttttc aagggaatgc ttccagtttt tgcccattca gtatgatatt 810060 ggctgtgggt ttgtcataga tagctcttat tattttgaaa tacgtcccat caatacctaa 810120 tttattaaga gtttttagca tgaagggttg ttgaattttg tcaaaggccc tttctgcatc 810180 tatgcagata atcatgtggt ttttgtcttt ggctctgttt atatgctgga ttacatttat 810240 tgatatgtgt atattgaacc agccttgcat cccagggatg aagcccactt gatcatggtg 810300 gataagcttt ttgatgtgct gctggattcg gtctgccagt attttattga gggtttttgc 810360 atcaatgttc atcaaggata ttggtctaaa attctctttt ttggttgtgt ctctgcctgg 810420 ctttggtatc agaatgatgc tggcctcata aaatgagtta gggaggattc cctctttttc 810480 tattgattgg aatagtttca gaaggaatgg taccagttcc ttcttgtacc tctggtagaa 810540 ttcggctgtg aatccatctg gtcctggact ctttttggtt ggtaagctat tgattattgc 810600 cacaatttca gatcctgtta ttggtctatt cagagattca acttcttcct ggtttagtct 810660 tgggagagtg tatgtgtcga ggaatttatc catttcttct agattttcta gtttatttgc 810720 gtagaggtgt ttgtagtatt ctctgatggt agtttgtatt tctgtgggat tggtggtgat 810780 gtccccttta tcatttttta ttgcatctat ttgattcttc tctctttttc tctttattag 810840 tcttgctagc agtctatcta ttttgttgat cctttcaaaa aaccagctcc tggattcatt 810900 aattttttga agggtttttt gtgtctctat ttccttcagt tctgctctga ttttagttat 810960 ttcttgcctt ctgctagctt ttgaatgtgt ttgctcttgc ttttctagtt cttttaattg 811020 tgatgttagg gtgtcaattt tggatctttc ctgctttctc ttgtgggcat ttagtgctat 811080 aaatttccct ctatacactg ctttgaatgc gtcccagaga ttctggtatg ttgtgtcttt 811140 gttctcgttg gtttcaaaga acatctttat ttctagcttc atttcgttat gtacccagta 811200 gtcattcagg agcaggttgt tcagtttcca tgtagttgag cggttttgag tgagattctt 811260 aatcctgagt tctagtttga ttgcactgtg gtctgagaga tagtttgtta taatttctgt 811320 tcttttacat ttgctgagga gagctttact tccaagtatg tggtcaattt tggaatacgt 811380 gtggtgtggt gctgaaaaaa atgtgtattc tgttgatttg gggtggagag ttctgtagat 811440 gtctattagg tccacttggt gcagagctga gttcaattcc tgggtatcct tgttgacttt 811500 ctgtctcgtt gatctgtcta atgttgacag tggggtgtta aagtctccca ttattaatgt 811560 gtgggagtct aagtctcttt gtaggtcact caggacttgc tttatgaatc tgggtgctcc 811620 tgtattgggt gcatatatat ttaggatagt tagctcttct tgttgaattg atccctttac 811680 cattatgtaa tggccttctt tgtctctttt gatctttgtt ggtttgaagt ctgttttatc 811740 tgagactagg attgcaaccc ctgccttttt ttgttttcca tttgcttggt agatcttcct 811800 ccatcctttt attttgagcc tatgtgtgtc tctgcacgtg agatgggttt cctgaataca 811860 gcacactgat gggtcttgac tctttatcca atttgccaga ctgtgtcttt taattggagc 811920 atttagtcca tttacatgta aagttaatat tgttatgtgt gtatttgatc ctgtcattat 811980 gatgttagct ggttattttg ctcgttagtt gatgcagttt cttcctagcc tcgacagtct 812040 ttacaatttg gcatgttttt gcagtgactg gtactggttg ttcctttcca tgtttagtgc 812100 ttcctttagg agctctttta gggccggcct ggtggtgaca aaatctctca gcatttgctt 812160 gtctgtaaag tattttattt ctccttcact tatgaagctt agtttggctg gatatgaaat 812220 tctgggttga aaattctttt ctttaagaat gttgaatatt ggcccccact ctcttctggc 812280 ttgtagagtt tctgctgaga gatccactct tagtctgata ggctttcctt tgtgggtaac 812340 ccaacctttc tctctggctg cccttaacat tttttccttc atttcaactt tggtgaatct 812400 gacaattatg tgtcttggag ttgctcttgt caaggaatat ctttgtggca ttctctgtat 812460 ttcctgaatc tgaactttgg cctgccttgc tagattgggg aagttctcct ggataatatc 812520 ctgcagagtg tttttcaact tggttccatt ctccccatca ctttcaggta caccaatcag 812580 acgtagattt ggtcttttca catagtccca tatttcttgg aggctttgct catttctttt 812640 tattcttttt tctctaaact tcccttcttg cttcatttca ttcatttcat cttccatcac 812700 tgataccctt tcttccagtt gatcgcatcg gctcctgagg cttctgcatt cttcacgtag 812760 ttctcgagcc ttggttttca gctccatcag ctcctttaag cacttctgtg tattagttat 812820 tctagttata cattcttcta aatttttttc aaagttttca acatctttgc ctttggtttg 812880 aatgtcctcc tgtagctcag agtaatttga tcgtctgaag ccttcttctc tcagcttgtc 812940 atagtcattc tctgtccagc tttgttccgt tgctggtgag gaactgcatt cctttggcag 813000 aggagaggcg ctctgctttt tagagtttcc agtttttccc catctttgtg gttttatcta 813060 cttttggtct ttgatgatgg tgatgtacag atgggttttt ggtgtggatg tcctttctgt 813120 ttgttagttt tccttctaac agacaggacc ctcagctgca ggtctgttgg agtaccctgc 813180 cctgtgaggt gtcagtctgc ccctgctggg gggtgcctcc cagttaggct gctcgggggt 813240 ccggggtcag ggacccactt gaggaggcag tctgcccttc tcagatgtcc agctgcgtac 813300 tgggaggacc actgctctct tcaaagctgt cagacaggga catttgagtc tgcagaggtt 813360 actgctgtct ttttgtttgt ctgtgccctg cccctagagg tggagcctac agaggcaggc 813420 aggcaggcct ccttgagctg tggtgggctc cacccagttc gagcttcctg gctgctttgt 813480 ttatctaagc aagcctgggc aatggggggc ccccctcccc cagcctcact gccgccttgc 813540 agtttgatct cagactgctg tgctagcaat cagcaagact cagtgggtgt gggaccctcc 813600 aagccaggtg cgggatatag tctcgtggtg cgccgtgttt taagctcgtc agaaaagcgc 813660 agtattcggg tgggagtgac ccgattttcc aggtgccgtc cgtcacccct ttctttgact 813720 aggaaaggga actccctgac ccctgtgctt cccgagtgat gcaatgcctc gccctgcttc 813780 ggctcgcgca tggtgtgcac acccactgac ctgcgcccac tgtctggcac tccctagtga 813840 gatgaacccg gtacctcaga tggaaatgcc gaaatcaccc gtcttctgcg tcgctcaggc 813900 tgggagctgt agacgggagc tgttcctatt cggccatctt ggctcctccc ccccaggcac 813960 aatactttct aaaggcacct tgaagcctaa aagagccctt cttatactct gaggtatctc 814020 accactgaaa ctggttacat acatctgtat tgggaattaa tggataaggg tggaacaaat 814080 gaaatgcatt tctgggggcc agatattcca aagcagtttg gggtagcctt cttcctcctc 814140 ctctgcaatg ctttgttagt tggaggctgt aaacatgccg atgctttccc aaatttgtgg 814200 gaatgaatgt gaatcacagt ttttggggct tcaatctcct ctgcggacac ataaaaagga 814260 actttcatca atttctaaca aggtttgaga tctatgcctg gatagagctg gatattgatg 814320 caaaagtaag aagcaaaaga tgatttcctt gagttccagc aatttcaata aaaaacacag 814380 agaccagact tgcaacaaca ctatagtgtc aaagagctgg ttcccaaagg ggagcataga 814440 gtccacccat accagagaca gacgagatct aacacttttt gagtttaata ttaatgttgc 814500 agcatggtaa tgaaaactag taaaagaatc tctcttggta aatgaatctt cactcccaaa 814560 cggcaagcag gaaaaaccct aaataaataa tgtgagattg atatcagagg cccatgtgca 814620 gggactcgat tacaattctt ggcttgtact caggggccct catgcatttt ttaagagctc 814680 atcaatattg tgatccttct gcttgctggt gaactttaaa aactacaccg aggtataaaa 814740 gtagggcttt gactttgttg aggcttatga ttcttctcaa ataaagtaga tctgaataaa 814800 agacggattg gaaaatcttc cctggccttt aggcaagcac agaacttagc agtggttttg 814860 gagcacccac tatggaacga tccatgagat ccaaagatgg atacagttcc cacacaacag 814920 ccacaaggaa ccacacattg gggaccacct gaagcagaac cctagctggg ggcttggcct 814980 tgttctgcca tgaagctgac agagctgttt ctacaacaat gtgcatcttg aatcatccca 815040 cagaaggagc tgagttaggc tggaaatgag agaattccag acagagggaa ggtatatttg 815100 tggagttgta ggaggccaga aagttgaagg ctggagacta ggggcaaggt tggaggctgg 815160 agaccagggg tcaaggcaag gaagacaagg ctgacccctc agacgctagt aagtctctac 815220 tgtgagagca gcaggaagcc atggaagggg gttaaacaga ggaaggttga ctcttactgg 815280 aaatgatggc ttgtctccca tttctggttt gggatacagg atgccttagg ccctggtgcc 815340 agcagagtgt acaggaggcc acattggaag acgatggtct ttgctgtctt cttacctttc 815400 tgtatgctcc ctgggccttc gtgtggcttt agcttctcac aaggcctcac tgggctgtgt 815460 atgtgtgtgc gtgtttgtgt gtgtaggtgg tgactgacca tcttctatga gctgggcttt 815520 gtattatttc ttgaccttct caagatttgc ctgtctcatg tcttcagaac ccattgcctg 815580 cagtctttga tacacactat tctgataaat gaatgagact gtgaggagtg ttaatttaag 815640 atattaaccc ttttatgtgt tagggtaata cccagtgtct ttttactcag gagatattca 815700 atcagtaggg attcaataca cgagtgtcgt atatttgtgt tttaaccggg tctgtctgag 815760 atgcagtgaa cgttcagtta gcctgggcag ccttctttct tgtcatctgt agagctggaa 815820 tctgggagct tccttctggt cactcagcag ggacaaagag gcctctaccc ccacatcact 815880 gttctctaag gtacatgcct cccccatcac tttccacctc tcgaggaact ggcacagccc 815940 aggatttcgc aatgattaga actgaacccc aataagctac ccaagaaaaa cagtgagcct 816000 tttaaggggc tcagaagtca gacaagagaa tcagaacaca gggaatacat gttctggaac 816060 aagaggacac aaacaccagc ttagcaactg cagcaagtac agtgaaccag ccagaccacc 816120 ggacaaggtc agaggtacag gggatggcct cttgaacaca gtggcaggag gatggttgca 816180 gggtagtggc tgcagaagac cccatgtaca tacatgctaa gcttttattt caggcaaagg 816240 gcttagagtt ctaagcttga gaacccctca gaacaggtcc tactgtcact ttctgagtct 816300 gagggagagt tactaagaag acactgaaat tctataagag cccttaagaa gctaaaattg 816360 caaatactcc tcagagagac ctggatttcc agcagaaatc aggattagca catgccaata 816420 tttaggtcga catcgagtgg gcgtgaacag cagtatgtgg aggctttgtt ggatggcccc 816480 agggttcttt taacctaaaa ttctatggga gtgtttgaag ggtcgtagtt cagagggaac 816540 tcttgatccc tgttgtgaac gccaagctca ttcctatctc ctggccttta tctttgctca 816600 gctctctgga ccaccagaag gatctttgca gggctccttc catcccatca tttacgtctc 816660 attgcctgag aggcctttcc gggccattct ttccaaaata ctcccctccc acgttttatc 816720 cccttcctgg atttgcttct ccacccagca ctcaccacag tcgggaacga tactatttgt 816780 ttgtttactt gatcagtggg gatctctgtg ggtcttgtct atcaatcact gcatcctcag 816840 ttcccaaaac aggaccagtc atttagtgtc cactcaacac acgcatggca aaaaaagaca 816900 gaggagcagg gaggctgaga gggagggagc aagccttcct ctagaagggt ggaacgcaga 816960 gcagtgcagt gagaatgtgt gtgtgcctgt gtgtatccat gcatgggagc atgtgcttat 817020 gtatccacgt acatgtgcat gtgtgtcaac atatatgtgt ccatgcatgt gtacttgtgt 817080 gtgaatgtgt atgtgtgcac gcatgtgtgt gcgcaagcac acgtgtaggc atcaaagaga 817140 cttgcatttg aaaggagacc cttagtataa tatttatgat aaacatttca aaactgagtt 817200 ttagtgatgt gcagaacaga ggaggaagat gcaagccccg aggcttggca ccccagctgc 817260 ctgagccaag tcctcaggca gtgagggaga tataggtaag tgaagctggg ggtgggggtt 817320 atttagctct gaagattgga ctgctggtgt cttgttttga tttcagagcc aacatgacag 817380 atacccagac ttcagagagg gaaaacagca tggtcaaaat gacaactgag aatacggtgg 817440 ccagccttgg tcagaatagt gctgacctgt gcagaggtag gctctttctt caggtaaggg 817500 ctcctggcct ctctgcatgc cttggggccc gcctcctact ctccaccctc acaccctcag 817560 gagagagtga tgcaagatga atggatccta aaattaaaat ccagtaactc tttcgaatta 817620 ctggcaattt agtgaattaa caagttggca ccaggcagtg gccttttccc actaaaaaaa 817680 aaaaaaacaa cctcaaatgc attccccaag gaaggggctg aaactcataa ccttgtgtct 817740 ggggcccaga gggcatgagc acagagatcc aaaggggctg atgctttccc taccactagt 817800 ggggcaggct gtgttagggt gcatgtctga aacttgaaac tgaattaagt agcttcatgt 817860 aatggcttct cttgacggca caggataaac atcataagaa gaagaagcag taatccaaga 817920 aggtttgcaa ctggctcaaa atgctacctg aaaccaagaa ttggaagcca ccttgaccca 817980 gaggaaaaaa aattgttaaa ctttgcagct atttctcaaa agaatagaga attttgtttt 818040 ctgtttgtag agatgggaat agtcatccct tatggaagaa gacaataatt tgctgcattt 818100 ttaggacttg taattgtaca ggcaaattca aaattcaggt agcattaaaa ttacagctag 818160 ataatgctgc ctgctttgtg gatagctatc ctcatttcaa gggagagcac ccctttatct 818220 gttgaagaga tgtctttttg atttgctaag ggcaagaatg gaaaataagt gcgaatagga 818280 acagctccgg tctgcagctc ccagcgtgag cgacgcagaa gacgggtgat ctcggcattt 818340 ccatctgagg taccgggttc atctcactag ggagtgccag acagtgggtg cgcacactgt 818400 gcgtgagccg aagcagagcg aggcattgcc tcactcggga agcacaaagg gtcagggagt 818460 tccctttcct agtcaaagaa aggggtgacg gacggcacct ggaaaatcgg gtcactccca 818520 cccgaatact gtgcttttct gacgggctta aaacatggcg caccacgaga ttatatcccg 818580 cacctggctt ggagggtcct acgcccatgg agtctcgctg attgctagca gagcagtctg 818640 agatcaaact gcaaggtggc agccaggctg ggggaggggg gcccgccatt gcccaggctt 818700 gcttaggtaa acaaagcagc ctggaagctc gaactgggtg gagcccacca cagctcaagg 818760 aggcctgcct gcctgcctct gtaggctgca cagacaaaca aaaagacagc agtaacctct 818820 gcagactcaa atgtccctgt ctgacagctt tgaagagagc agtggtcctc ccagtacgca 818880 gctggacatc tgagaagggc agactgcctc ctcaagtggg tccctgaccc cggacccccg 818940 agcagcctaa ctgggaggca ccccccagca ggggcagact gacacctcac agggcagggt 819000 actccaacag acctgcagct gagggtcctg tctgttagaa ggaaaactaa caaacagaaa 819060 ggacatccac accaaaaacc catctgtaca tcaccatcat caaagaccaa aagtagataa 819120 aaccacaaag atggggaaaa actggaaact ctaaaaagca gagcgcctct cctctgccaa 819180 aggaatgcag ttcctcacca gcaacggaac aaagctggac agagaatgac tatgacaagc 819240 tgagagaaga aggcttcaga cgatcaaatt actctgagct acaggaggac attcaaacca 819300 aaggcaaaga tgttgaaaac tttgaaaaaa atttagaaga atgtataact agaataacta 819360 atacacagaa gtgcttaaag gagctgatgg agctgaaaac caaggctcga gaactacgtg 819420 aagaatgcag aagcctcagg agccgatgcg atcaactgga agaaagggta tcagtgatgg 819480 aagatgaaat gaatgaaatg aagcaagaag ggaagtttag agaaaaaaga ataaaaagaa 819540 atgagcaaag cctccaagaa atatgggact atgtgaaaag accaaatcta cgtctgattg 819600 gtgtacctga aagtgatggg gagaatggaa ccaagttgaa aaacactctg caggatatta 819660 tccaggagaa cttccccaat ctagcaaggc aggccaaagt tcagattcag gaaatacaga 819720 gaatgccaca aagatattcc ttgacaagag caactccaag acacataatt gtcagattca 819780 ccaaagttga aatgaaggaa aaaatgttaa gggcagccag agagaaaggt cgggttaccc 819840 tcaaagggaa gcccatcaga ctaacagtgg atctctcggc agaaacccta caagccagaa 819900 gagagtgggg gccaatattc aacattctta aagaaaagaa ttttcaaccc agaatttcat 819960 atccagccaa actaagcttc ataagtgaag gagaaataaa atactttaca gacaagcaaa 820020 tgctgagaga ttttgtcact accaggcctg ccctaaaaga gctcctgaag gaagcactaa 820080 acatggaaag gaacaaccgg taccagccac tgcaaaatca tgccaaaatg tagagaccat 820140 caagactagg aagaaactgc atcaactaac gagcaaaata accagctaac atcataatga 820200 caggatcaaa tacacacata acaatattaa ctttacatgt aaatggacta aatgctccaa 820260 ttaaaagaca cagactggca aattggataa agaaagagtc aagacccatc agtgtgctgt 820320 attcaggaga cccatctcac gtgcagagac acacataggc tcaaaataaa aggatggagg 820380 aagatctacc aagcaaatgg aaaacaaaaa aaggcagggg ttgcaatcct agtctcggat 820440 aaaacagact ttaagccaac aaagatcaaa agagacaaag aaggccatta cataatggta 820500 aagggatcaa ttcaacaaga agagctaact atcctaaata tatatgcacc caatacagga 820560 gcacccagat tcataaagca agtcctgagt gacctacaaa gagacttaga ctcccacaca 820620 ttaataatgg gagactttaa caccccactg tcaacattag acagatcaac gagacagaaa 820680 gtcaacaagg atacccagga attgaactca gctctgcatc aagtggacct aatagacatc 820740 tacagaactc tccaccccaa atcaacagaa tacacatttt tttcagcacc acaccacacc 820800 tattccaaaa ttgaccacat acttggaagt aaagctctcc tcagcaaatg taaaagaaca 820860 gaaattataa caaactgtct ctcagaccac aggtcaatca aactagatct caggattaag 820920 aatctcactc aaaatcgctc aactacatgg aaactgaaca acctgctcct gaatgactac 820980 tgggtacata acgaaatgaa accagaaata aagatgttct ttgaaaccaa cgagaacaaa 821040 gacacaacat accagaatct ctgggacgca ttcaaagcag tgtgtacagg gaaatttata 821100 gcactaaatg cccacaagag aaagcaggaa agatccaaaa ttgacaccct aacatcacaa 821160 ttaaaagaac tagaaaagca agagcaaaca cattcaaaag ctagcagaag gcaagaaata 821220 actaaaatca gagtagaacc gaagcaaata gagacacaaa aaacccttca aaaaattaat 821280 gaatccagga gctggttttt tgaaaggatc aacaaaatag atagactgct agcaagacta 821340 ataaagagaa aaagagagaa gaatcaaata gatgcaataa aaaatgataa aggggacatc 821400 accaccaatc ccacagaaat acaaactacc atcagagagt actacaaaca cctctacgca 821460 aataaactag aaaatctaga agaaatggat aaattcctcg acacatacac tctcccaaga 821520 ctaaaccagg aagaagttga atctctgaat agaccaataa caggatctga aattgtggca 821580 acaatcaata gcttaccaac caaaaagagt ccaggaccag atggattcac agccgaattc 821640 taccagaggt acaaggagga actggtacca ttccttctga aactattcca atcaatagaa 821700 aaagagggaa tcctccctaa ctcattttat gaggccagca tcattctgat accaaagcca 821760 ggcagagaca caaccaaaaa agataatttt agaccaatat ccttgatgaa cattgatgca 821820 aaaatcctca ataaaatact ggcagaccga atccagcagc acatcaaaaa gcttatccac 821880 catgatcaag tgggcttcat ccctgggatg caaggctggt tcaatataca caaatcaata 821940 aatgtaatcc agcatataaa cagagccaaa gacaaaaacc acatgattat ctcaatagat 822000 gcagaaaagg cctttgacaa aattcaacaa cccttcatgc taaaaactct caataagtta 822060 ggtattgatg ggacgtatct caaaataata agagctatct atgacaaacc cacagccaat 822120 atcatactga atgggcaaaa actggaagca ttccctttga aaactggcac aagacaggga 822180 tgccctctct caccactcct attcaacata gtgttggaag ttctggccag ggcaattagg 822240 caggagaagg aaatgaaggg tattcaatta ggaaaagagg aagtcaaatt gtccctgttt 822300 gcagatgaca tgattgtgta tctagaaaac cccactgtct cagcccaaaa tctccttaag 822360 ctgataagca acttcagcaa agtctcagga tacaaaatca atgtacaaaa gtcacaagca 822420 ttcttataca ccaataacag acaaacagag agccaaatca tgagtgaact cccattcaca 822480 attgcttcaa agagaataaa atacctagga atccaactta caagggatgt gaaggacctc 822540 ttcaaggaga actacaaacc actgctcaac gaaataaaag aggatacaaa caaatggaag 822600 aacattctat gctcatgggt aggaagaatc aatatcgtga aaatggccat actgcccaag 822660 gtaatttaca gattcagtgc catccccatc aaggtaccaa tgcctttctt cacagaattg 822720 gaagaaacta ctttaaagtt catatggaac caaaaaagag cccgcattgc caaggcaatc 822780 ctaagccaaa agaaaaaagc tggaggcatc acactacctg acttcaaact atactacaag 822840 gctacagtaa ccaaaacagc atggtactgg taccaaaaca cagatataga tcaatggaac 822900 agaacagagc cctcagaaat aatgccgcat atctacaact atctgatctt tgaccaacct 822960 gagaaaaaac aagcaatggg gaaaggattc cctatttaat aaatggtgct gggaaaactg 823020 gctagccata tgtagaaagc tgaaactgga tcccttcctt acaccttata caaaaatcaa 823080 ttcaagatgg attaaagact taaacgttag acctaaaacc ataaaaaccc tagaagaaaa 823140 cctaggcatt accattcagg acataggcat gggcaaggac ttcatgtcta aaacaccaaa 823200 agcaaaggca acaaaagcca aaattgacaa atgggatcta attaaactaa agagtttctg 823260 cacagcaaaa gaaactacca tcagagtgaa caggcaacct acaaaatggg agaaaatttt 823320 cgcaacctac tcatctgaca aagggctaat atccagaatc tacaatgaac tcaaacaaat 823380 ttacaagata aaaacaaaca accccatcga aaagtgggtg aaggacatga acagacactt 823440 ctcaaaagaa gacatttatg cagccaaaaa cacatgaaaa aatgctcacc atcactggcc 823500 atcagagaaa tgcaaatcaa aaccacaatg agataccatc tcacaccagt tagaatggca 823560 atcattaaaa agtcaggaaa caacaggtgc tggagaggat gtggagaaat aggaacactt 823620 ttacactgtt ggtgggactg taaactagtt caaccattgt ggaagtcagt gtggcgattc 823680 ctcagggacc tagaactaga aataccattt gacccagcca tcccattact gggtatatac 823740 ccaaaggaat ataaatcatg ctgctataaa gacatatgca cacgtatgtt tattgcggca 823800 ttattcacaa tagcaaagac ttggaaccaa cccaaatgtc caacaatgat tggattaaga 823860 aaatgtggca catatacacc atggaacact atgcagccat aaaaaatgat gagttcatgt 823920 cctttgtagg gacatggatg aaattggaaa tcatcattct cagtaaacta tcgcaagaac 823980 aaaaaaccaa acaccacata ttctcactca taggtgggaa ttgaacaatg agatcacatg 824040 gacacaggaa ggggaacatc acactctggg gactgtagtg gggtgggggg aggggagagg 824100 gatagcactg ggagatatac ctaatgctag atgactagtt aatgggtgca gcacaccagc 824160 atggcacatg tatacatatg taactaacct gcacaatatg cacatgtacc ctaaaactta 824220 aaataataaa agaaaaaaag aaaagaaaat actgctaaaa tacatccaac tcaatacttt 824280 tggtaaatat tacttgttgc taataaaaag tttagatata agaaaaaaaa aaagaatgta 824340 ttgtgcctca ttcatttgtc taaaggcaag agcaccaagg ctcaaaaggg tcacaaaact 824400 acctggaggc agaagcagag gcagagacag gatttcaaca ccaagccctg cactctgtaa 824460 ctactgctct ttccactgga atcagctcct gcctcagcgg gtgccaatgg agaaagacct 824520 gggggttttg ccttctgatt acagttccat tggaccatct cttattttct tccatgaaga 824580 actgaggtcg taactccttg tggactagta ttctgaggct gaggggtaca actgcttatc 824640 ctggttgaat tcaatgcttt ataagtagaa ttaaagtgaa ataaggaaca cttggcctta 824700 tgaattctga tcatctaaaa cagagtttct caacagcagc accgttagta tttgaagcca 824760 gatcattctt cgtggcaggg gctattctga gcattggatg atgttgagca gcacccctgg 824820 cctctgacca ataggtatca atagtgtcac cctcccctgt gttatgacaa tcaaaatgtc 824880 tccagacttt gctacatgtc ccctggggac aaagccaccc tcagtggaga gcctctgatc 824940 tagtgttcag atattttccc ctagtgtggt gcctgggaga tagcaagaac catagcaaga 825000 accattgttt gatgatggat taatggaatg cacatccatt ttctgaattg cttcattctt 825060 gttatttcag tattgatttt gccatccttc ttccaagaac tgaaatacat tcaaaccttg 825120 cgtgtgtctg aatagattga gaaaattcag gaagttttgc tttcctaggt ttcagctaaa 825180 aggaggcagg tttagttcag cagttttccc acagtcaggc caaccatggt tctaatgcac 825240 cgttagtgga gggggacaag ctctgagtgt gaatctgctg atggatgtgg ggcctgcaga 825300 aggaatctgt acatttcagg accagaggca aggaggagct tgtgatacta gtatgcaaag 825360 tggttagaga aagagagaga aatcaatgct gacctattta atcagaactt ttggagacat 825420 taatggcact gaaggtcccc agagggcagc aacagaagga tgagaaatga agcatgatgt 825480 caaataagaa agcaaaatgc tgcaataatg ggtaaagcgt ctcatcctca aggcggaagt 825540 caaagcagct gcctgggttc cctccagaaa ggcagtgatg ggtgcagcct gtgatctgca 825600 ctgggttttg gtgaggctga tgagaaaaga atgagaaatg ggtgccccag tgatggatgg 825660 gccagtggtc cttgtatggt gcacacatct ttaaagctcc acaagggccg ttcaaagtgg 825720 gtggtacaca tttattctca tagtactcac ctttctggtg ccctcttcct ccactgctcc 825780 ttaccactgt cccagatggt taccatgttc cccttttccc ttctctattt gtgactctgt 825840 ctctaatttt tatctgtcta ccgacctgcg tagctatgtt tcttttcttt tttttttttt 825900 ttttttttga gacggagtct cgctctatcg cccaggttag agtgctacgt ttctttcttt 825960 ctgcctccct gtgtgtgttt ccatctctct gatccctctc tctctctctg tgtgtctctt 826020 cccctctctc tcatccatcc tccctcacac ccccccagcc ttattcatct cagcctcccc 826080 tgaccctggt atgttcctgc atctcagtcc ctgaactcag tttcccagag cccttctctg 826140 tgcttggcca tctccacctt ctccatccct caccctcact tagggtctct gacaggaagg 826200 gcattggcct cagggcagag cacagtgggt tcatggtgtg caaatccacc attacagccc 826260 aaagaagtca gcagggggac cctgtcccaa aggcccaggc aggactctgt gagcctttgt 826320 attcatgctg ggcctgggct ggagacacta actgggttta gctcactggg aaggaaccgg 826380 cagtgcgggc aggtaggtga gcagggcaga aggagggcat ggaagtgagt tcaagctcag 826440 ttcctcctgc cgtcagacca tgagctggat cctcctacca gcgctagtcc tttccttctc 826500 catgcctcaa cttccccttt cagtatgctg ctcttccagt tagattttcc ctcccatatc 826560 tctctcctct ctctctctct ctcacacaca cacacacacc acacttttct tgatgtgtat 826620 gccctgcttg ctgtcttatt gcactcagct acctctttgt ccctcccctg cttcatgttt 826680 ttaccccttt tctatgcctt tgatttcgtg gatagaagtt ttagcacaag ggaaacaaaa 826740 caaggaaaag aaggaaggaa ggaaggaagt tagttttcat gttgcctgag actgggtaat 826800 ttataaagaa gagatttaat ggactcacag ttccatgtgg ctggggaagc ctcacaatca 826860 tggcggaagg tgacaggcac atcttatatg gtggcaggca agagaaaaat gagagccaag 826920 tgaatggggc aaccccttat aaagccatca gaccttgtga gactcatcca ctaccatgag 826980 aacagtatgg gggaaaccac tgccatgatt caattacttc ccactgggtc cctcctacaa 827040 cacatgggaa ttatgggagc tacaattcaa gaagagattt gggtggggac acagccaaac 827100 tatattagaa ggaaaataaa ggaaagaatg gagggaatga gagaaagaga taaagagaca 827160 ggaggaaggg aaagaaggag ggagaagggg aaggggggaa atgtggagaa aggttgaggg 827220 aagcaaagca gaggaagtga agtgacacca tagagtatgg aaatcattgc caaaaatata 827280 agtgaatttt gtcatagctg gttttactga aacaagtact aagactgggc atttgccttt 827340 gccagtgttt atggcaatga tagatttaca cacagggatg ccgagggcat ttgcacccag 827400 tggaggtgag tacccatgac atggtgaccc aatatggtga ccctggagtt caaagcacaa 827460 aggatccttg gacttcttct ggatccctgc tacttttcac tgcatgggag aactggagag 827520 ggtcctgaat ggtaagctgt ggggcaggtg agctggggag taccagacac acccaagaag 827580 gccctgctcc ctgtggaaac agattcctta atccagggaa agctttcaca tgcattatct 827640 aagttactct tcaccacagc cctctatgct agattctgct attactccca ttttatggat 827700 aaggaaactg agcccagatc tagacctgtc agataaatgc aggcaatgtt atcctggcct 827760 ctattcctca tcaccacaat taaagccaag ggctggtttc tcccatgtga cacaggcaga 827820 tggcaggcag ggcactgggg aatgctgtgc caatgtcccc atggtcacca cagtctcaca 827880 catcatgtgt ctctttctgg atcaataact gcatgagttg tcttgctatg tgtaggcatc 827940 ttaagcatat aggaggacaa ttagagaatc caggtcctca gaggctttgt tgatgagcac 828000 atgggctggg gttttaaaga acataagtgc ctgtaataac agagcttacc gctgactact 828060 ctggtgctct cttctctgta agtgcattaa ttattgagag aactcatttg cagcacgcac 828120 acagttgaaa gggctacttt ggacgctaat cagaaaatac acattgttga agggagctaa 828180 ttagagaatc acacaacttt gtagagcttt gcctgaaaaa ctggatcaat cagagatatt 828240 ggatattcag agatacttgt cagacctgca ataaacaaat acatgtaggc attgcatgta 828300 aagatgtaac actgagctgt ttccattagg aaggattttt atttctcatc tgtccatttc 828360 agtgactgga gccctcttga taactacatc tgaagtggga gcccctgcag gcaggatgca 828420 gatattatga gtcctatctt ttgatttcaa acacgtttct tccttccaat ctaagacctg 828480 cgcattctgc agtccagccg ggaccacaat gctattactt tgtggaggtt taataagccc 828540 tgtgcattca atggggagtc actaaaatag agatttatcc ccaaatctgt tgcaacacat 828600 tacaaatatg tcaagcgttc gtgattgagt cgggtctcag aaagagcatg aggcattctt 828660 gacctatata tttaaagaac cctggaggta aatgtctgtc ccatttcctc aaatatacaa 828720 acaacatgat aaaaataata ttgaataaaa ataatttaaa atttaaaata aataaataat 828780 aaaattaaca atttgtttat cagattctta ggaataaaga cataatcact ttcaggagat 828840 tgaatgtata aaactacaaa tcgcaagact ggtcaattaa ggtgtattga ttcacataca 828900 aaaggatgtt cacattacaa aagaattatt caattttttc ttaatgacag ctctgttaat 828960 gctttcatca ctttttttgc aaataatccc tggttagaga agactgaaga ataactacca 829020 taaacgaaca ttagtaattt tcaatgccat caagtttcat aaagttttaa aaactcaaat 829080 tctttcagga acaaagctat tctatatggc aagagattcc tgaaccctcc acattagtgt 829140 ctataatggg taggcctcat gccattatat ttttctaagc caaagttcag atgcatcaag 829200 ttaccaaaac cctttttaca agaatgccaa attatgtaat tccttcctat aagaatgtta 829260 tgggccaggt gcggtggctc acgcctgtaa tcccaacact ttgggaggct gaggcgggtg 829320 gatcacccga ggtcaggaat atgagaccag cctgaccaac atggagaaac cctgtctcta 829380 ctaaaaatac aaaaattagc caggcgtggt ggtgcatgcc tgtaatccca gctactcagg 829440 aggctgaggg gggagaatcg cttgaaccgg gaggtggagg ttgtggcgaa ccgagttgca 829500 ctccagcctg ggcgacaaga gcaaaactcc atctcaaaaa aaaaaaaaat gttatggccc 829560 atttattgtc taggtattta ttactgagct tcccttggat ccagttgaca gtaggaagcc 829620 aacgttgaat tagaatgcct ttaatttcag tgagcccagt ccagtgtcgc tggggtcatt 829680 tagtgaatta catgctgcca ttcccagtga aatcatataa ctactcatca tcacttagta 829740 gaataaagat atcctgaaaa agctaaatgg agttttgaat cataaatccc aagtggtgca 829800 acaatgtaat aacacaatga caaagaaatc atttgctgca tttcccaaaa ataaggtcat 829860 tgctcctgtt gttcgcggaa aaaaattttc aagacgggta ataacatttt gaaaatttgt 829920 atgctcattt aaattgtata aaatgcattt ttagggcttg atttggccat atttattttt 829980 agttctctta tacttttttt tttttttttt gagatggagt ttcatccttg ttgcccagga 830040 tagagtgcaa tcgtgcagca acctccaatg cgcaggttca aaagattctc ctgcctcagc 830100 ctcctgagta gctgggatta caggcgtgta ccaccacgtc cagctgattt ttctattttc 830160 agtagagacg gggtttcccc attttggcct ggctggtctc gaacacctga cctcaggtga 830220 tccattgcct aggcctccca aagtgggcgg ggattacagg ccagttctct tatactcttg 830280 aatagtcctt tccttctgtt atgctggttg ttctttttct gtgggtaaac ttgaaggtgt 830340 ttcctaaggt tcaggcttta aacactgtct aaacacatat cactttcatt gccccgctag 830400 cagagcagct ggctaatggc agccctcact tggctcaggt ggtctcagat cccctcagcc 830460 tgcaccttcg gggcctatgg gtccaaaggg gctggatgag gaaggctcaa ttaattattg 830520 ttagcataca gtaacataag gaaagcaggg gatattttga agcaaaagaa acaagaatgt 830580 tcagttactt tagactcaga aaacgagcag tgagtcatcc tagagctacg tttctatgat 830640 aaaaatacct actagatatc ttgtcttgaa tgtccccagc tgcatcaaac tcagcaggtc 830700 tgaaactaaa cccttcatct tttgtcatca aagtacgatc tttcccctat acaccctttc 830760 acagttagtg atttcactgt ccacacagtt tcctgagctt agagcctggg aaggagtcac 830820 ccctaacccc ttctcctctg tcaccactcc cacttgtcat tgactctgaa gccaccttcc 830880 ttggaccccc ttcatatctc acaatttaat tccctctctc acatcccaca gctgctcctg 830940 agctcagacc atcatcatat ctctctccct gcacatcctt taccctgggc cctcgctcca 831000 ggaccacaca ccaccagccc attctctaga cagagttttg cacctggtat gtcacgagtt 831060 acaggtgtgc caagatggtg agtccttcag acctcaaggt ggccagaaac agctccctgg 831120 gttcatccca gtgtactgca caaatacccc ttgtctgcct gttcctcaaa aagtgggaag 831180 cactgggctg gataaggcac actgtctgta ccaaaacagc agaaactcag acccagcgtc 831240 agtccagctc aagtcaggca gtgttggttg caaagtggac ctggtggctg ggccctaatt 831300 gtgctcatgc tttgcaagga ggtgatggga tatattaaag ccttgaaaca gggccctgaa 831360 gatgggaatg agaaggagtc aaggccaggt ggctcatgtc tgtaatccca gtgctttgag 831420 aagctgaggc aggagcatca cttgagttca agagtttgag accagcctgg gaaaccaagc 831480 aagaccctgt gtctccagaa tattttaaga ataataatta gccaggcatg gtggtatgta 831540 actgtagccc tagctactct ggaggctgag gtggaaggtt tgcttgagcc caggagtttg 831600 aggctacagt gagccatgaa tgcaccattg cactctagcc tgggcaacag agcaagactc 831660 tatctcttct tgtttaaaaa agaaaaaaaa aaaaaagagt caagagatat tttgccggta 831720 gaattaacct ggagagaaag gtgtcagtga aacctctgag gtttcaagga tggaaggatg 831780 gtgataatgt tacacaagat ggagcacaca ggagagaagc agtatttggg attgggaggg 831840 gatggggttg gccttcatta actgaattgg tagactgtgg ccttcagaat tccagatgga 831900 cactcgtgtg gaaatgccta gcaaagcacc taaaattcac atctagggct caggagaaag 831960 agcaaaatgg aaaagataga tgggaatgtt atttataaag caatgaggaa agcagccaag 832020 ccttccgaga gaggcctgag agcaggccac tgaacactcc gtatttagag gaaagacaga 832080 gaaaaggatc cagtcaagga aagtgagaaa gggtggccag aaatgtaggc agagatctgg 832140 aagaccacag tgccctggca gctgaaaggg ccaacaacaa aaatatcaac ggcatcaaat 832200 gctatagtaa tgcaggtagg aagaggacga agaggaaacc agagaatttg gcaatgagag 832260 gtcagggtga cctttcagta gctgatggtg aaagaagctg tgtcagttca ggtttttgag 832320 aagcgcctag caagacagat tagacacaca aggaatttat tggggaaatt cttgtgaaga 832380 aggaagcaaa aggaagcagg aggtggcaag gagagtctgg agaccataac agaggtccga 832440 cacctgtgag aggagaaggc gaaggaggga ttggttggag gcacgtcagg ctgcggtgca 832500 cttctgagaa ggctgcagtg aggctgatgg ggtatccctg agcaaaggat gcctgttagg 832560 gagatcctgc atcgggcggg gacggccatg agaaaagccc tgtcacgctt gtcattggct 832620 tgcagcatcc cagagaacac atgcctccct tcctgcagca gatgctcttg gtttttttgt 832680 tttggtttgg gttttttgtt tgttttgttt tgttttgttt tgttttgttt gagtcttgct 832740 ctgtcaccca ggctggagtg cagtggcata atctcagctc actgcaacct cctcctcccg 832800 ggttcaagcg attctcctgc ctcagtgtcc ccagtactgg gactacaggc gcccaccatc 832860 atgcttggct agtttttgta tttttagtag agagggggtt ttgccatgtt ggcctggctg 832920 gtcttgaact cctgacctca ggtgatcctt ccgcctcggc ctcccgaagt tctaggatta 832980 caggcatgag gcacaccgtg cccagccagc agatgctctt gaaggagacc tgaggttatg 833040 tttgcgtggc accacagaag ccagagtgac cataagcagg aagtagaaac actagaattc 833100 tggtctaagc tgctgtcatc tctatacaca gcatggctga aacagaagag ccacgcagaa 833160 gttagcaggt aggcagggcc tggtaagaag gccataagct gtggcgcttt cacccaaagc 833220 catcatgaag acccataact aagtggctgg ccaaggtcac aaggtttcat agaattgcca 833280 ggacgagagc cagctgtcca tcttcgcttg gcgtccctgg ctctctcctc aaaccctgtg 833340 ctctccctgt acttccaatc acatgcgggg tttggtctat caccgttcgt acccagtgga 833400 cactgatgcc tttgatgtat gtttttcttt caacgatggt gtgttgaagg attctgttac 833460 ctccattcct ccatttctgt acaagtaagt taatacaagt aagtaagtac tgtaggaaaa 833520 tgagctcctc ccgcgcccag ggaggaggta ggaggacgat tccacctgtc tttgtggtga 833580 gcgctgaagg aggatcttga gaaaggcacc tgtgtgcagc ggcattctca tctctaaagc 833640 ccgcatggct tcccgtgtgc acacaggaca ttctgcccat gtttaccaaa tgaagacacc 833700 aactaactac cctgtctttc cttctaggtg acctcataca tttgcctcca taccttagaa 833760 tggacttttt gttaaaccga ggtggtccag gcaccagcag ggacctgagc ttaggacaag 833820 catgcttgga acctcagaaa agccggaccc tgaagcgccc cacggtcctg gagcccatcc 833880 cgatggaagc cgcctcctcc gcctcctcca cgagagaagg acagtcgtgg cagccggggg 833940 ccgtggccac attacctcag cgggagggag cagagctggg acaggcagct aaaatgagca 834000 gctcccaaga atcactgctc gactcccggg gccatttgaa aggaaacaat ccttacgcaa 834060 aatcttacac cctggtataa cagacagcat gactggacag cggttgtaaa tacaattcaa 834120 acaattcaat caaagctacc ttttttttac ggaattccaa tatttataat taaagaaaat 834180 tgccaaaata tattaaaaaa aaaaaagaga aaatactgaa accacagaca gtgcaaagac 834240 tctcctgctt tttttctgtc tgagtgtgag ctccatccgc ctgggcatct gattttttgg 834300 gaaagaagtc cagttttatg atcttcacag gctattgcat ttttactgat tttctacaaa 834360 agtgcatggg ggggattaat taaaccttct gactggaagt tctatcacac aagaggcaag 834420 aaagaaaaca gggtgggtgg gaaatcagcc tatttgtgaa tttaaaagga acaccgattt 834480 gcgggcaggg gaaaacttca gtcacgtttg cacacctttc tttcccatta gaaaccgggt 834540 tctcaatttg gtcttctttt gttgttaatt aggatgagtg ccgtcagtga aggggtgggg 834600 ggaatcaatt tggttttctc tcttgtttct tttttaattt aatgagacac tctttgcatt 834660 ttgtctaagc gaaataaaaa agaaaaggtt gtctgccttt atttccatgt ctgcttctct 834720 cgtcttctgc cagtggcctg gtcctccttc ccattgacac ttctgtttgg aaacaccagg 834780 cctgaaccca gagcccaatt caataaacca gagtcgatac taacaccctg aactcctcag 834840 gaatctccag gaagcacaaa gaaggtgcag ctcctgctct caagctggag aggacaaaat 834900 gcaggctggt ctccaccgca accagaggcc agcccaagta ttcgaagccc gtcgcaaagc 834960 tctgcccctt gcctgcccat ggccagagtt caactgactg tggcctatgg gccaaatcca 835020 gcctcctgct gttttttaaa taaagtttta ttgaaacaag gccacatgca ctatttgcta 835080 ttgtctatgg ctgctttcat ggcacaatgg tagagctgaa tagttgcagc agagatggta 835140 tagcccatga agcctaaaat atttattacc tggcccatta caggaaacat ttgccagacc 835200 cgtgctctgg agtctgaaat gtagccccag cttgcgtgac aaggggcaag atcgtgcatc 835260 ttaccctcca tgacttttcc tatctccact atgcctggta tgcaaatttg tgatagacca 835320 tcttaataaa cattgcctga atcctctgta accagaggaa agtgatgttc ctctaaaatc 835380 taagttttta ctttcctttc cctcacttta tctcccatgt ggctcatcct aagagagaat 835440 ttactcataa atagtcggaa ctgcattctt tatcccacaa ccctcacagg gtttgcttta 835500 tgaaagagga tgtaatcctc ccctggctgc aacactccat tccaggctca cttccataaa 835560 atggaaagat aaacaggtct ttgtgtcaga gatttggcat taaccagaaa acatgatcaa 835620 atatccacag ctgctcagtc tcccaggctg aagattctct acaggcttcc attaaggcca 835680 ccaacataga ctggtgccag ttattaccat cttgggaaca tattcagaaa tgtctttcct 835740 tccctccctc cctccttctt tcccatcctt tcttccttct atttattttc caggcaggcc 835800 catttgtctg cttagattca gtgacacaga atgggtccag gaccatgtca agaccacctg 835860 ctgatgctag tgttagatga ctccaggaat gtgaggtgtg catccatggt ttcagaatgt 835920 aatccgtgtt gacgtgtact gtttgcatac tctcagactg tttttttttt atgcaaaaga 835980 aatgttactt tctgggggaa aaaattaaaa gtctatcttt catcaaccta aaacttctat 836040 atcccccaaa catagaagtt taccttttta acatttttct ctcaacctgt acaaaaataa 836100 aaaaattcta catta 836115 <210> 201 <211> 92 <212> DNA <213> Homo sapiens <400> 201 attggaaggt cagccaatca ggcgcggagc tgctcccggt agctgccacc tccgaggcgc 60 gcgccacgcc ggggttccct cgcggctttg ga 92 <210> 202 <211> 87 <212> DNA <213> Homo sapiens <400> 202 tccgtgtgct ccaccctttg aattcagaac gacatagtgg atactccgtg gggctgctgg 60 aatcttccat tcccactgcc ttatctt 87 <210> 203 <211> 99 <212> DNA <213> Homo sapiens <400> 203 aaggtgcgaa ctcctctttg tctctgcgtg cccggcgcgc ccccctcccg gtgggtgata 60 aacccactct ggcgccggcc atgcgctggg tgattaatt 99 <210> 204 <211> 71 <212> DNA <213> Homo sapiens <400> 204 tgttcactgg aggactcatc agaggtccca ttctcctttt tgtgtctttc atcaaacacc 60 ctcatggact g 71 <210> 205 <211> 22 <212> DNA <213> Homo sapiens <400> 205 attggaaggt cagccaatca gg 22 <210> 206 <211> 19 <212> DNA <213> Homo sapiens <400> 206 tccaaagccg cgagggaac 19 <210> 207 <211> 20 <212> DNA <213> Homo sapiens <400> 207 cgcctcggag gtggcagctc 20 <210> 208 <211> 20 <212> DNA <213> Homo sapiens <400> 208 tccgtgtgct ccaccctttg 20 <210> 209 <211> 24 <212> DNA <213> Homo sapiens <400> 209 aagataaggc agtgggaatg gaag 24 <210> 210 <211> 22 <212> DNA <213> Homo sapiens <400> 210 ccagcagccc cacggagtat cc 22 <210> 211 <211> 22 <212> DNA <213> Homo sapiens <400> 211 aaggtgcgaa ctcctctttg tc 22 <210> 212 <211> 22 <212> DNA <213> Homo sapiens <400> 212 aattaatcac ccagcgcatg gc 22 <210> 213 <211> 23 <212> DNA <213> Homo sapiens <400> 213 cccctcccgg tgggtgataa acc 23 <210> 214 <211> 20 <212> DNA <213> Homo sapiens <400> 214 tgttcactgg aggactcatc 20 <210> 215 <211> 19 <212> DNA <213> Homo sapiens <400> 215 cagtccatga gggtgtttg 19 <210> 216 <211> 28 <212> DNA <213> Homo sapiens <400> 216 aggtcccatt ctcctttttg tgtctttc 28 <210> 217 <211> 182411 <212> DNA <213> Homo sapiens <220> <223> PCDHGA1 <400> 217 tctggatgac tctccagtca gaattctcct gaaaattggg ttaatttcag ctcagaaaag 60 cagaaacgat acccttggta ctggactgga agaaaactac gaagtgagag agccatgaag 120 attcagaaaa agctgactgg ctgcagcagg ctgatgcttc tgtgtctttc tctggagctg 180 ctgttggaag ctggggctgg gaatattcac tactcagtgc cggaagagac agacaaaggt 240 tccttcgtag gcaacatcgc caaggaccta gggctgcaac cccaggagct ggcagatggc 300 ggagtccgca tcgtctccag aggtaggatg ccgcttttcg ctctgaatcc tagaagtggc 360 agcttgatca ccgcgcgcag gatagaccgg gaggagctct gcgctcagag catgccgtgt 420 ctcgtgagtt ttaatatcct tgttgaggat aaaatgaagc tttttcctgt tgaagtagaa 480 ataattgata ttaatgacaa cactccccaa ttccagttag aggaactgga gtttaaaatg 540 aatgaaataa cgactccagg taccagagtc tcattgcctt ttgggcaaga ccttgatgtg 600 ggtatgaact cactccagag ctaccaactc agctctaacc ctcatttctc cctggatgtg 660 caacagggag ccgatgggcc tcaacatcca gagatggtgc tgcagagtcc cttagacaga 720 gaagaagaag ctgtccacca cctcatcctc acagcttctg atgggggtga accagtccgt 780 tcagggaccc tcagaattta cattcaggtg gtggatgcaa atgacaatcc tccagcattt 840 actcaggcac aataccatat aaatgtcccc gaaaacgtgc cgctgggtac tcagctgctc 900 atggtaaatg ccactgaccc tgatgaggga gccaatgggg aagtaacgta ctcctttcac 960 aatgtagacc acagagtggc ccaaatattt cgtttagatt cttacacagg agaaatatca 1020 aataaagaac cactagattt cgaagaatac aaaatgtatt caatggaagt tcaagcccag 1080 gatggtgcgg ggctcatggc taaagttaag gtactgatca aagttttgga tgtaaatgat 1140 aatgccccag aagtgaccat cacctctgtc accactgcag ttccagaaaa ctttcctcct 1200 gggaccataa ttgctcttat cagtgtgcat gaccaggact caggagacaa tggctacacc 1260 acatgtttca ttcctggaaa tttacccttt aaattggaaa agttagttga taattattac 1320 cgtttagtga ctgaaagaac actggacaga gaacttatct ctgggtacaa catcacaata 1380 acagcaatag accaaggaac tccagctcta tctactgaaa ctcacatttc actactagtg 1440 acagatatca atgacaactc cccagtcttc catcaggact cctactctgc ctacattccc 1500 gaaaacaacc ccagaggagc ctccatcttc tctgtgaggg cccacgactt ggacagcaat 1560 gagaatgcac aaatcactta ctccctaata gaggacacta tccagggggc acccctatct 1620 gcctacctct ccatcaactc cgacactggg gtcctgtatg cgctgcgatc cttcgactat 1680 gagcagttcc gggacatgca actgaaagtg atggcgcggg acagtgggga tccgcccctc 1740 agcagcaacg tgtctctcag cctattcctg ctggaccaga acgacaacgc gcccgagatc 1800 ctgtaccccg ccctccccac agatggttct accggcgtgg agctggcgcc cctctccgca 1860 gagcccggct acctggtgac caaggtggtg gcggtggaca gagactcggg ccagaacgcc 1920 tggctgtcct accgcctgct caaggccagc gagccgggac tcttctcggt gggtctgcac 1980 acgggcgagg tgcgcacggc gcgagccctg ctggacagag acgcgctcaa gcagagtctc 2040 gtggtggccg tccaggacca cggccagccc ccgctctccg ccactgtcac gctcaccgtg 2100 gccgtggccg acaggatctc cgacatcctg gccgacctgg gcagcctcga gccctccgcc 2160 aaacccaacg attcggacct cactctgtac ctggtggtgg cggcggccgc ggtctcctgc 2220 gtcttcctgg ccttcgtcat cgtgctgctg gcgcacaggc tgcggcgctg gcacaagtca 2280 cgtctgctac aggcttcggg aggcggctta gcgagcatgc ccggttcgca ctttgtgggc 2340 gtggacgggg ttcgggcttt cctgcagacc tattcccacg aggtctccct cactgcggac 2400 tcgcggaaga gccacctgat tttcccccag cccaactatg cggacacact catcagccag 2460 gagagctgtg agaaaaaggg ttttctatca gcaccccagt ctttacttga agacaaaaag 2520 gaaccatttt ctcaggtaaa cttttgtgat gaatgtatca gctatctaga gaaaaataat 2580 tcttgattta acttactagc gttcgctctt tgctacagat agttcttcta acccatgtat 2640 ctttgtagct ttttattaca agtcctgcaa aatcacgatt gagtctacac gttcatatgc 2700 aggtatattt ataattgttc ttgcactgaa aaggagactg tgatcataat gtaggtggtt 2760 gggttgaagg tatgtgtgag atgccatctc tgtttggaaa gagcactgca ttagaaacgg 2820 cgatctagct tctaacattt tcttacttgc ctctgggcta aaaggtttga ttagaaaagg 2880 ctcaccaata tttaaatgac taacactatt ttcaaatttt ctttttataa gtacctgcta 2940 atctacccct gaatttaatg tagatgtcat ctgtcaggac actgtgatag tttatttggg 3000 gacatttgaa gaggtgaaga ttgtctaaag tagtattttt agttgtgttc atataagatt 3060 atagagatct atataaactg caattttaaa ttattgttga atattttagc cttttattct 3120 atctttatta tcagattttt ttggttttga gatggggtca tgctagagtg cagtggcatg 3180 atcatggctc actgcagcca ctacctcctg ggctcaagcg atcctcccac ctcagcctct 3240 caaagtgctg atattacagg tgtgagctgt ggtgcctgta ctgaagaata cgtctattta 3300 agtaatgtat gaagtaacaa aatgaacaac acaaaattta tcatgcaact tgagaaatat 3360 ctttgaagcc tcctgactta tacattatac ctgtaatgaa atcagctaac aaaaatcaag 3420 tatatatcct attttaatgt gtgttaactt ttcagaagaa aaaaaaagta tggtcgggga 3480 gtaagtccat gctttgatgt atttactctg ctccaataaa atacagagat acataaaata 3540 taagaggaaa gcaaaagcaa agtggtgagc tagtctaaag ccatgtgagt tatagtcttg 3600 gacttaaaag cagaaattga aggttaggaa actgcctcca gcaatgtaat agggacagaa 3660 gtgcttcaga ctagataaat atctggacca ggcttactgc ctgaatccaa aataagcaat 3720 gaggcccttc agctggttaa aaaggaaaag aaagatgcat taacatgctg cctagctggg 3780 cgcagtggct cacgtctgta tttccaacaa tttgagaggc tgaggcggaa agatccttgg 3840 agccctggag ttcaagacca gccggacagg gcggcctgcg actgtagtcc cagctacgcg 3900 gggcggggag gggcggggcg gggcggggca ggagctgacg tgggaggatc ccttgagccc 3960 aggaagtcaa ggcttcagcg aaccgtgatc gcgccactgc cctccagcct gggcgacaga 4020 gccacaccct gttaaataaa taaatataat aataaaagct gtttcccaat tccggtggtt 4080 ataactttct tcgtaagctg tgtagaccaa gagagagaga cagacacgga tgctggatag 4140 agacagcgaa caccaagtat ctcatatgtg agctgtggta tccagaatat cactgctgtg 4200 catcattaaa gcgtcattaa gagacctagt tatggcctgg gacctgaggt cagatagaaa 4260 ctatttcaaa accattacaa atgagcactg aacccaggag ggaaggagag agggatatag 4320 tgtagaagag aaaaaaacaa actaaaacta aaaacaaaca gagctcttcc actaaaaata 4380 aatatacaaa ccaaaatttc aaaacacact tgtctcgtag aatttattgt tactagtgag 4440 aaactttctg tcaacacact gttatttttt aaggtaatct ctgttttctc tctggtaact 4500 attgaagact ttctctcatt cttgctgtgt gtctgttgca tttttatttt tattttttgc 4560 ttggtaccaa gagtatactc tcaattgata actaagttat ctcacttctg gactttctca 4620 gctcttataa tcataatttt ttttctgtgt atatacaagt gagctacatt tacctattaa 4680 aggacaaata ttacaaaact ggttgatttt taaaatccat attctaataa tacacgtgct 4740 taaaataaaa atacactgaa acagtgaaac taaatatata tgtacacaca caaaaaagaa 4800 agtcatgtta atgtaacaac aaagtcatat ttaaggtaac aaacacaaat tgtgatttta 4860 aaaaatgaac tgattatagt tgtaaaaaga gcagatgatc aaaaggatat aaaaatataa 4920 gcttctatta ctgaaaaata tagcttagaa aataccggaa tatttaaaca taattccata 4980 agaaataata gaccccacag gaagaaagtt agttaacata aagaagattt gaacaacata 5040 atttagaagc ttgatctatt aggattctaa tagatccgtt ctgcacacaa caaatatgga 5100 atagtcatcc ttgaacaagc agacaatcta caagtttatt acctagtcat tacaaaaaag 5160 ggttcagcaa attgcaaagt accaataata tacttgcctt acaacacata cttaatcaca 5220 aagcaaacat ttaaaaatag aaaagggaaa aagtttggat atttacatct acacccttaa 5280 ataactcttg gatttcaaaa atcacaatga caatgaaaac tactcagaaa aaaaggactt 5340 aaatattctt tattaaaaat tgtgagatgc aactaaaact aattaggagt aagtttatag 5400 acaaatgcaa taattttttt aaaagcaaac aaaattattt aaaatacatg aatttagctt 5460 gccattcaag aagtaagata aaaaacatac aatgagtata tactaaaata aaatgatgga 5520 aaaaataaca aagagttaca tttttgaaat gcaaccatgg aagagttctg aggatgaaat 5580 aatggaagca gacaataaat gtaataaaac cagtggggag aaaatgaaaa ttctgtcaag 5640 tctaacgtta ggactcatgt aagagagcca ggcacaatgg cacacctata atcccaggta 5700 ctgagtaggc tgaggcagta ggattgcttg agcccaggag tttgaatcca gccggggcag 5760 tataacaaga cccaatctct ataaaacaaa aaaacacaaa cacaaacaca aaaataaaaa 5820 taaaaaacaa aagcaaaata taccatagta gctctacaag aaaacatggt gagttggtat 5880 caattatttc caatatattt ttcttcagtc ttgtaagagg aatggatgaa agtaaaaatg 5940 agaaaatttc aataaggaag gagccaaaag gcaaacagat taaagtgtca ccagaaatgg 6000 gcaattccac ttatgccaca tacaaaaatt aattcaaaat ggatcaaaga agcaatattc 6060 agaagcaata aaaccctttt agttattatg tttaagaact aaaactatac aactcttaga 6120 agaaaacagg aggaaacctt cataacattg atttttggca atgatttctt ggatatgaca 6180 ccaaaagcac aagcaacaaa agaaaaaaat tgtatactgg actttatcac agttaaaaac 6240 tatatgcagc aaagaacaat atcaatagag tgaaaaggca gcccacagaa agagagaaaa 6300 tgtttccaaa tcatgtatct gagaatggat atccagaata aagaactcga actcaacaac 6360 aaagaatccc aaacaattgg atgttaaaat gagcaaagga cttgaataga catttctcca 6420 aagatgatat acaaatggcc aaaaccatat gaaacaatgt tcaacatcac tagtcattag 6480 ggaaatgcaa atcaaaacca taatgagata ctactccaca ttcattagaa ttgctgtcat 6540 aaaagaaaag aaaagaaatg ttaacaagaa tatggagaaa ttggaattct tgtgcattgc 6600 tggtgaatat aaaatgacac aactgctgtg gaaaatggta tggtgactcc tcaaaaattt 6660 aaacatagaa ttaccatata atccagcaat tccactctgg ttattaccca aaagaagtga 6720 aaatagggac ttcaacagat atttgtacac ctatgtttat ggcatcatta gtcacaatag 6780 ttgaaaagtg gaagtaaccc aagtgtccat tgacagatga atgggtaaat aaaaagtggt 6840 tcacacatac aatgggctgt tatttagcct taaaaaggaa gggaattctg ttacatgcta 6900 caatatggac gaacttcaaa gacatgatat caagtgaaat aaacctgtta taaaatgaca 6960 aatactgtat gattcctcat atatgaagtt cctagattag tcaaattcat agagaaaaaa 7020 ggtagaatgg tagttgccag ggactgggtg aaaggcaatg gggagttgct atttaataag 7080 tacagagttt cagttgggga ggatgaaaaa gttctggaag tggatggtgg taatggtcac 7140 accagaatgt aatttgaatg tacttaatgt cacagaattg tatgcttgac tatggtcaaa 7200 atggtaaaga tgaaacaaga gtaagaagac atccactgca ttgtatttta cacccttgga 7260 aaatgaatat cagaaaaaga acttgacaac ctcaaacaat tttgagtgac tgattcctag 7320 tgtggtgaaa aaccccttcc ggctctagct ttatcaaata gacctgcttt ctgtttctgt 7380 aatgttccat gctgtctctt accttcaagc atttgttcag aggttctaga acacttcttc 7440 agcctttttc ttgattcaat cctacttttt atgattcagc ttcaatcatg ccctcaaaaa 7500 gacttttctg accccaaatc tagactggat acccctccta ggtattcctc catcacccag 7560 tgtttcctac ctcatatcac agcagttacc atactctatt atactctctt tactttctta 7620 tgtcctcctc caaccttcac gcttgagacc agggcctgtg tttatcatgt tcaccatttc 7680 tagctccagc tgcaatcatg caaagtggga ggcacatgta cccaattaag tgtctgatga 7740 ttcaataatt taaaggcaga ttttgaaggt aaatgcaaag ccatcaacca taaacgttca 7800 aaatatataa ccttagaaga aaacgtagct aacgtttctt aattgatctt actgcttctg 7860 attatacaat aagagatgga agatgtttgg agcaagggca gtggtggcat tgattaatgc 7920 cttgagcagt caataatact ttcctagcaa ctattatcaa gatcatgttc atttatacca 7980 ttcttattaa tcctgataaa aagattcctg ttttgaaaga tctaattcta gggtatctta 8040 gagctgtaag attctttaaa gcgccttgaa agtcaacaaa ggcaaacaaa caagaagtaa 8100 cttaggtttt cctgagcagg tgcagaaatt atttaggcct ctgagcgtcg ctgttgacca 8160 cctaaggagt aaaaggcagc gagacatcca atccagcaat acggctccca cagcacaagg 8220 gggtggaggt ttggccctaa agcttcagga caccaaagaa attcagtcga acagcccacc 8280 agttctctcc atagggacct gggtcccgtg aatgctggtt atctcacacc ctgaggaata 8340 aagattggaa tccgcactgg atgctggaag ttgactcgga gaaaattgcg acaggaggga 8400 aatggcggct ctgcaaaagt tgccacactg cagaaagctg gtcctgctgt gcttcctttt 8460 ggcgaccctg tgggaggcca gggccgggca gattcgctat tctgtgcggg aagagatcga 8520 cagaggctcc ttcgtaggca acatcgccaa ggacttgggt ttggagcccc tggcactggc 8580 agagcaggga gtccgcatcg tctccagagg taggtcccag ctctttgctc tgaacccgcg 8640 aagcggcagc ttggtcactg cgaacaggat agaccgggag gagctctgcg ctcagagcgc 8700 accctgtctg ttgaatttta acattctgct ggaggataaa ttgactattt attcagtaga 8760 ggtggaaata acagatatta acgataatgc ccctcgcttt ggagtagagg aactggagct 8820 aaaaatcagt gaaaccacta cgccaggatt ccggattcct cttaagaatg cgcatgatgc 8880 agacgtaggt gagaacgccc ttcagaagta cgcactcaac ccaaatgacc acttctccct 8940 ggacgtgcga aggggagctg atgggaacaa gtacccagaa ctggtgctgg agcgctctct 9000 ggaccgcgag gaagaggctg ttcaccacct cgttctcgtg gcttctgatg ggggtgaccc 9060 agtgctatct ggcacctccc gcatctgcgt gaaggtcctg gatgcgaacg acaatgcgcc 9120 tgtttttaca cagcccgagt accgcataag cattccggag aatacgctcg tgggcacccg 9180 gatactcacg gtgaccgcca ctgacgcaga tgagggctac tacgctcaag tggtatattt 9240 tctagagaaa agccctggag aaacctcaga ggtatttgag cttaagtcaa catctggaga 9300 actgacaatc ataaaagatc tagattatga ggatgctaca ttccatgaaa ttgatattga 9360 agctcaggat ggtccgggcc ttctaaccag agcgaaggtt atcgtcacgg ttctggatgt 9420 gaatgacaat gccccagaat tttacatgac atctgctact agctcagttt ctgaagactc 9480 tcttccagga accataattg ggctttttaa tgtacatgat agagactctg ggcagaacgc 9540 attcaccacc tgttcactcc ccgaggatct tccttttaag ttagaaaagt cagtagacaa 9600 ttactaccga ctggttacaa ccagagccct tgacagggaa cagttttcct tttacaacat 9660 cactctaacc gctaaagatg gagggaaccc ctccctgtcc acggatgctc acattttgct 9720 ccaggtggca gacatcaacg acaacgcacc cgccttctcc cgcacatcct actccaccta 9780 cattcccgaa aacaacccca gaggagcctc tgtcttctca gtgacggccc atgaccccga 9840 cagcaacgac aatgctcatg taacttactc tttcgcggag gacactgttc agggggcacc 9900 cttatcctct tacatctcta tcaactccga cactggagta ctctatgcac tgcgctcctt 9960 tgattatgag cagttgcgag acttgcaagt gtgggtgata gcgcgggaca gcgggaaccc 10020 tccactcagt agcaatgtat cattaagcct gttcgtgctg gaccagaacg acaacgcgcc 10080 cgagatcctg taccctgcct tccccacaga cggttccact ggcgtggagc tggcgccccg 10140 ctccgcagag cccggctacc tggtgaccaa ggtggtggcg gtggacagag actcgggcca 10200 gaacgcctgg ctgtcttacc acctgctcaa ggccagcgag ccgggactct tctcggtggg 10260 tctgcacacg ggcgaggtgc gcacggcgcg agccctgctg gacagagacg cgctcaagca 10320 gagcctcgtg gtggccatcc aggaccacgg ccagccccct ctctccgcca ctgtcacgct 10380 caccgtggcc gtggccgaca ggatccccga catcctggcc gacctgggca gcctcgagcc 10440 ctccgccata cccaacgatt cggacctcac tctgtacctg gtggtggcgg tggccgcggt 10500 ctcctgcgtc ttcctggcct tcgtcatcgt gttgctggcg cacaggctgc ggcgctggca 10560 caagtcacgc ctgctgcagg cttcaggagg cagcttgaca ggcatgcaga gctcgcactt 10620 tgtgggcgtg gacggggttc gggctttcct gcagacctat tcccacgagg tctccctcac 10680 tgcggactcg cggaagagcc acctgatttt cccccagccc aactatgcgg acacgctcat 10740 cagccaggag agctgtgaga aaaaggattt tttatcagcg cctcaatctc tactcgaaga 10800 agaaagagaa gaaacgtttt ctcaggtaat ctatcttttc acaacatacg tactagctag 10860 tttgctgaag taattcactt acttgtttac tatatctatt ttgttcccca tatttccttg 10920 agggtagagt caagttttag gaagtgagtc ttggtgaatt atttcttggt aggtcttagt 10980 gttcacaggc tgtaagagga agaagagacg tgagaatctt tgtgcaatga atgtaaacca 11040 ggagttaata gataagatta tccaaagagc actgcattag gaactagggt gtctggtttc 11100 ttatactttc ttctccatcc ctgggcaaat catctcatcc acccagatca acaatttttt 11160 ctttgttaaa aatataaaga ttggagttta tgtttactca agtcctttct tcttttaagt 11220 tatgactctt actctatatt tgaatctgta tatgaacagt gaaacatgtt agttggctag 11280 ttctttctca ttcagtctta atacatttct ttcagtttgg cagcaaaatt gttttcctta 11340 acttgcatgc ccttccctgt taaaaatatg gaaatttaga aatatacatt ccttacagtg 11400 tttcaggaag gtatgtcata ttattttggc ttagttttaa aaatcacatt aacctctaag 11460 ctatatgctt cttgaagaag tgactgactt atcatctgct ctataataaa gctgtagagt 11520 ggtaataaac aggtttctcc ttttttttta tctttctcat acgtgggaac catactgtat 11580 tttaatcttt aaaataatat atatcctcaa tatagttttg cttaaagaaa agatacaaaa 11640 gattcatatc atacaattgc ccagaaccaa cttctttata catctctctt ctcaaggttt 11700 ctactcacaa tagctgctag aaatgttccc aatccctcac ccaatcccag tgcccctctg 11760 atcaattttc ttttcccatt cctcttccta tattggcttt tagtatgttg gttatgtatt 11820 taataacaga gaataataag cacactaatg ttctatgtaa ctggcatcat tttttatttt 11880 tatttgaaaa ttatcatgta ccaattgagc cttttattga atgataccat atttctcaaa 11940 gtgctgtgat tctttccgtt gcatttgatc aagaaaaaat tttctgagac aaggtgttgt 12000 tttggttact attacataat tgtctatgag taaaattgga actcactgtg gaataatatg 12060 tcataatagc tttacttgta agtgaataat aaagtataaa caggaaaatt aaagcaaagt 12120 tatttttagt gtgtgtagta actccacaag aataaatgtc ttatgcatag atatgtaatg 12180 catcatgatt gaaacgacaa atatattgta tttatatttc tgtgcttgga aacttatggg 12240 gaaagagatt ctggaacata aaagcttatt tctactagtt tcagttggtt ttgaaaaaac 12300 atccttacag tctagattta aacaaaggaa acttctttca gtaccctgaa ggtctgtgat 12360 ttctctctca cacctaggca ttgtcatgct gttctctccc acatccaggc cttttcactg 12420 atccactcct ctcatgtttc ctgggaaagc gtttgctaac attaaaggcc caattgaagg 12480 cccccctaac ccccttggct tctcccatta tggtaattat ctcagtacac tgcaattccc 12540 tgtttgcttt tatatcctta taatctctgt gaaggaagct actgtgtcta tattgttcac 12600 cttaaatccc caaacatatt gtctgatgcc taattatgtg tttgtttaat gaatattaaa 12660 taacaacaaa tatcgaaact aagttatcag gtcaccaaga acaaacttaa agaaatataa 12720 tgtataaata tggctgattt ctgtgtgttt cttttctttt tttccttgtc tcagctctta 12780 gagagttaag agtatagaga gggaaaggtc aaagaggagg tggatatctt atcaaataac 12840 cctgataaat gtagtaagta taagaataaa cacattatca aggttcagtg gtggaagaac 12900 aagtggtggt catgtctttt aatagttgtg ttggtcctta cggccagttc tttgttactg 12960 tgtgtttctt aaactgaaca attcaaaaaa gttaactcca ctatgtttga agcaatattg 13020 gtggcattaa ggttagtgca tggattccca agaaagataa cttgaggtga cactgtttaa 13080 catatatcga ttcaattatg ttcaatcaac actagtcctc ttatctctga caagaaggat 13140 ttcagatctt ggataattca aaaataataa tgtgtctgag aggatgcagt aaacggttag 13200 gcctcttagt gtcgctgttg accactcaag aaggagaacg cagctggaga actagtccac 13260 catttccttg ctcctaaaat gcaaagaacc agcaaatcag actcagaaga tccggggcgg 13320 ctgccaacct cacctcttag tcaaccagct gtttgacctg tgaattaggc ccgtaaaaga 13380 cttcgtttct tgagaaaata agattggagt ccgtcgtagg aaactggaac cgaattcaga 13440 gaaagcgatt caccgaaaag gaaatgacca attgcctgag tttccgaaat ggcagaggac 13500 tggccctgct gtgcgcgctc ctggggacgc tgtgcgaaac aggatccggt cagatccgct 13560 actcggtgtc tgaggagcta gataaaggtt ccttcgtggg caacatcgct aacgacctgg 13620 ggctagagcc ccgggagctg gcggagcgcg gagtccgcat cgtctccaga ggtaggacgc 13680 agcttttctc tctgaatccg caaagcggca gcttggtcac cgcggagagg atagaccggg 13740 aggagctctg cgctcagatc ccgctgtgtc tggtaaaaat taacattctg gttgaggata 13800 aattgaaaat ttttgaagta gaaatagaaa ttaaagatat taatgataat gctcctaatt 13860 tcccaacaga ggaattggaa ataaaaattg gtgaactaac ggttcctgga acccgatttc 13920 caattaaaac tgcttttgac ccagatgtag gcattaactc cctgcagaac tacaagctta 13980 gccccaatga ctacttctct ctggctgtga atagcgtctc tgagggggcc aagtatccag 14040 agctggtgct ggagcgggcc ctggaccgtg agaaaaaaga aattcaccag cttgtcctgg 14100 ttgcctctga tggtggcgac cctgtccact ctggcaactt gcacatccaa gtgatagtcc 14160 tggatgcaaa tgacaaccca ccaatgttta ctcagcctga gtaccgtgtg agtgtttggg 14220 agaacgtgcc tgtgggtacc cggctgctca cggtgaatgc cactgaccct gacgagggat 14280 tcaatgctca agtgtcttat attctagata aaatgcctgg gaaaatcgct gagattttcc 14340 atcttaactc agtgagtgga gaagtatcaa tattaaaaag tctagattat gaggatgcca 14400 tgttctatga aattaaaatt gaagcacagg atggaccagg tcttctttca agagccaaga 14460 ttctagtcac ggttctggat gtgaatgaca atgctccaga aattacaatc acgtctctca 14520 caagctcagt cccagaagag ggcaccgttg gaagagaaat tgctcttatc gacgtgcatg 14580 accgagattc tgggcagaat gggcaggttg aagtttttgt cctgggaaat ctgccattta 14640 agttagaaaa atcaatagat caatattacc gcttagtgac ggccacatcc ctggaccgcg 14700 aacaaatatc agaatataac attagtctga gagcctcaga tgggggaagc ccgccactgt 14760 ccacagaaac tcacatcacc ctgcatgtga ttgacatcaa tgacaaccca cccaccttcc 14820 ctcatttatc ctactccgcc tacattccag aaaacaaccc cagaggagcc tccatcttct 14880 cagtgacagc ccaggaccca gatagcaaca acaacgcccg catcacttat gcattgaccg 14940 aggacactct ccagggggcg cccctgtcct ccttcgtctc tatcaactcc aacactggcg 15000 tcctatacgc gctgagatcc ttcgactacg agcaatttag agacttaaag ctactggtga 15060 cagccagcga cagcgggaac cctccactca gcagcaacgt gtcgctgaac ctgttcgtgc 15120 tggaccagaa cgacaacgcg cccgagatcc tgtaccccgc cctccccaca gacggttcca 15180 ctggcgtgga gctggcgcct cgctccgcag agcccggcta cctggtgacc aaggtggtgg 15240 cggtggacag agactcgggc cagaacgcct ggctgtccta ccgcctgctc aaggccagcg 15300 agccgggact cttctcggtg ggtctgcaca cgggcgaggt gcgcacggcg cgagccctgc 15360 tggacagaga cgcgctcaag cagagcctcg tggtggccgt ccaggaccac ggccagcccc 15420 ctctctccgc cactgtcacg ctcaccgtgg ccgtggccga caggatcccc gacatcctgg 15480 ccgacctggg cagcctcgag ccctccgcca aacccaacga ttcggacctc actctgtacc 15540 tggtggtggc ggtggccgcg gtctcctgcg tcttcctggc cttcgtcatc gtgctgctgg 15600 cgctcaggct gcggcgctgg cacaagtcac gcctgctgca ggcttcggga ggcggcttgg 15660 cgagtacgcc cggctcgcac tttgtgggcg cggacggggt tcgggctttc ctgcagacct 15720 attcccacga ggtctccctc actgcggact cgcggaagag ccacctgatt ttcccccagc 15780 ccaactatgc ggacacgctc atcagccagg agagctgtga gaaaagcgag cctcttctga 15840 taactcagga tttacttgaa atgaaaggag attccaacct acttcaggtg agtttattta 15900 tttctttgat tattaagaac aaatatgaga atgtggttat tataaagctt taacacatat 15960 gtatttgaga aataaagcca tgaggttgtc attagtcctt tgactaaata tttgtccccc 16020 tttctttctg ggcctatagt aggactgcac tccccggtct ggttatggtt gagtgggctt 16080 agggaaaaaa taatacatcg tgagtgaaag taaagtgtca cttcctagag gaatctgcca 16140 ctgtgagaat tttcagatct ctaagttact atttgaaatt gtgactgctc cttctacctg 16200 ggtccttgag taactatgat gagagaaaca caacactggt ttgtatacct gtgataaata 16260 ggcctttttc attttaaatc cctgtgcttt ggagtttgtc attccaacct gtatagctta 16320 tcctgataca tacaagtaaa aatacatatg aataaaagat attttatgcc catgaaatta 16380 aatgatgttt gactccttcc aagacaggtg acactctttt tttctttctc cttccttcct 16440 tcctctctct ttcctccttc cttccttcct ctctctcttt cctccttcct tccttccttc 16500 ctctctctct ttcctccttc cttccttcct ctctctcttt cctccttcct tccttcctct 16560 gtttctctct ttctttcttt ctttctttct ttctttcttt ctttctttct tgacagggtc 16620 ttactctgtc tggagtgcag tggcatgatc acggctcact gcagccttga cctcgcagac 16680 tcaagtgatc ctcccacctc agcctcccga gtagctggga ctacaggcac gagccaccct 16740 cccagctaat ttgtttttgt ttttgtagag atggggcaat tgctatgttt cccaggctgg 16800 tctgaaattc ctgagctcaa gtgatctgcc cacgtcagcc tcccaaagta ctgcgattag 16860 aggcatgagc caccatgcct ggcctgttat tcttttcatc tcaataacat aaaaattgga 16920 gaacaaaaat gtagaggctg ggtgcagtgg ctcatgctgt aatcccagca ctttgggagg 16980 ctgaggcagg tggatcactt gaagtcagga gttcaagaac accctggcca acatggtgaa 17040 agcctgtctc tactaaaaat acaaaaatta gctgggcatg gtggtgggcg cctgtaatcc 17100 aagctacttg ggaagctgag gcagaagaat tgcttaaacc caggaggcag aagttgcaga 17160 gagccaaaat tgggccactg cactccagct ggggcaatag agagagactc catctcaaaa 17220 aaaaaaaaaa agtagaggct ggtcaaatgg ttttacctat agtgcctgtt acatatgcct 17280 aatgtatatg cttatgtgtg tattcatttt gatttcaaca ttttgcctga gggtggaaag 17340 ctcacctagc taaattatta tgagccttgg agtggtattt cttgtccttg agaaggacat 17400 caaaaacatg taaaggaata tgtctcagcc tctgcgggag atttccagac aatctcttcc 17460 aacaatggaa tagaagtccc ttcttttgtc atgttctaca actttcttga gccagaaatt 17520 gttggcttat tctgcaattt atgaaattat tttcactcat gaaatcatat gagagttatc 17580 caaaattaga ccaaaatatg ttttattaga actcaaacaa aagaatagat tcctccctca 17640 atatattagg aaaaggcaca tttaaatgta tgagacaaca gggccagaac acaaaagctg 17700 taagcagagt aaggtgtatt ctcactgaaa catggaaata catcacagaa tttaaaaggc 17760 ccatagccag gggaggactt ctgagcctag gactttgaga cctacttggg caacatagca 17820 tgaccctgtc tcaaaagaaa aaggcacgta acttttaaca tatcattttt agaaaaaaaa 17880 atgtttatag tattagtatc actttccctg taaggagaaa aaaaattaat tagctgtgtc 17940 aggggaaatt tggatgctca aagataattt ctaagaattc tatatgaaac atagcctaca 18000 tatgtgtcat gaaaatacac tgagagtatg gaacccatac aattccacct acttgtacag 18060 gtaatggaag gtctcagaca tcccattttc actaaaaagg atttattttt atttttttga 18120 agaatgggca agaatccact acaacagaaa gggaggagaa gttcatagta aaaggaatgg 18180 aaagtataaa ggcatgatgc aaggaaacaa gtgaaaaggt atcttaagaa aacagataat 18240 aggctgtttc gaatagagta tgagtatggg tgagcactgc aaaatagtag aataaattgt 18300 tgagttggat ctcatttggt aatgcatttg aaataaaggg atttgctttg aaccaagact 18360 ggttctaagc ctggaactac agaataagtt ccaaaattgg gtgtctaaga actctgaata 18420 cctctccaat atttaccagt ggtcaagtca aactcgtttt gctcattaat ggtataagtc 18480 ggctggagct gagaattggc attatagaga atgtttttga gacagagtct tgctctgtca 18540 cccaggatgg acttcagtgg catgatctca actcactgca acctctgcct cctgagttaa 18600 gtgattctgc tgcctcaacc tcccgagtag ctggcgttac aggtacccgc caccatgcct 18660 ggataatttt tatttttttt agtagagatg gcttgcacca tgttggacag gctagtctca 18720 aactcctgac ctcatgtgtt cttcccacct tggcctccca aagtgctggg atcacaggtc 18780 actgcaccca gcctagagta tttaatatac attcatataa aaaagaagca ctggtttcat 18840 aaaacaaatg tacattatat gagattccac ttcataaaag catgtatgtg taccccaaca 18900 ctaaattggc ccttttaaca aaatatcaga ctttgtccta cttaactgga aagattatct 18960 atattttata aagaagagaa ataacataat agtaaggctg tgatttcctc ttttttgcaa 19020 aaactatttt tgaaaagtat tactgaattg ataacatata tatggagaga tttaaaatac 19080 tagataaggg agcttattcc aatgaattta cagaaaggta ggtattttag tcaactaaaa 19140 atataaataa aaattatcaa ttcacttatt tggatacagc agtcatgcca gagtttataa 19200 atatagtgaa atcactgaag attttttttt acccccaaaa ctgaaaaaaa tggcagtgta 19260 ccttgtgaat tttttaaatg aaaaaagaat acgaaatgat gaaggccctt atctgatgat 19320 gacaaactag aaaactgaaa tgtaaagggg aaaatgtgag tatgtgtttc cctccagcaa 19380 attaaagaca gggtacatag attcaagagg ttgcgctttg aggataaaaa gctgggccct 19440 gtgcagtttt ccaagacaac ctctgggcgc cgctgtcgac caaaaggaag tgaaggcttc 19500 tcaattctgc aggagcgtca ggcagggtgc cttcctgctt tgtccggtgc actgagcaca 19560 gacgctgctc ctgttcaccc tcgagcgcct aactaataag tcctaagctc aaatcacaga 19620 agtccagggt gctgccattt ctttttgaaa aacatcccag aggaaagaag ctccgcggag 19680 agttcctgaa atgcagagag ccagagaagc cgaaatgatg aaaagtcagg tactgtttcc 19740 cttcctgctg tctttgttct gcggggccat ctcccagcag atccgataca cgattccaga 19800 ggagctagcc aacggctcac gggtggggaa acttgccaag gatctggggc tcagtgtccg 19860 ggagttgcca actcgaaaac tgcgggttag tgcagaggat tatttcaacg ttagtttgga 19920 gagcggggat ttgttagtga acggtaggat agatcgagag aagatttgcg gaaggaaact 19980 tgagtgtgca ctagaattcg aaacggtcgc tgaaaaccca atgaatgttt tccacgtggt 20040 tgttgtaatc caagatatta atgacaatgc accacgtttc gttgcaaaag gcattgactt 20100 agaaatttgt gagtcagcct tacccggggt aaaattctct ctggattctg ctcaagatgc 20160 agatgtggaa ggcaattcac tgaagttata caccatcaac cccaatcaat acttctctct 20220 gtcaacgaag gaaagtcctg atggaagtaa atatccggta ttactgctgg aaaaacctct 20280 agacagggaa catcagagct ctcatcgctt aatcctgact gccatggatg gcggggaccc 20340 gcctctaagc ggcaccaccc atatctggat ccgagttacg gatgccaatg ataatgctcc 20400 cgtgtttagc caggaggtat acagggttag cctccaagaa aacgtaccgt ggggaacctc 20460 cgtgctgcgg gtgatggcca cagaccagga tgagggcatt aatgcagaga tcacctatgc 20520 cttcctcaat tccccaataa gtaccagcct cttcaatctc aatccaaata ctggcgacat 20580 cacaaccaat ggcacattgg attttgaaga gacaagtaga tatgtgttga gtgtggaagc 20640 taaggatgga ggagtacaca cagctcactg taatgttcaa atagaaattg ttgacgagaa 20700 tgacaatgcc ccagaggtga cattcatgtc cttctctaac cagattccag aggattcaga 20760 ccttggaact gtaatagccc tcataaaagt gcgagacaag gattctgggc aaaatggcat 20820 ggtgacatgc tatactcagg aagaagttcc tttcaaatta gaatccacct cgaagaatta 20880 ttacaagctg gtgattgctg gagccctaaa ccgggagcag acagcagact acaacgtcac 20940 aatcatagcc accgacaagg gcaaaccagc cctttcctcc aggacaagca tcaccctgca 21000 catctccgac atcaacgaca atgcacctgt tttccatcag gcctcctatg tggtccacgt 21060 gtctgagaac aacccacctg gcgcctccat tgcacaagta agcgcctccg acccggattt 21120 gggacccaac ggcagagtct cctactctat tctggccagt gacctggagc cgcgggagct 21180 gttgtcctac gtgtccgtga gcccgcagag cggggtggtg ttcgcgcagc gcgccttcga 21240 ccacgagcag ctgcgcgcct tcgagctcac actgcaggcc agggaccagg gctcccccgc 21300 gctcagcgcc aacgtgagcc tgcgcgtgtt ggtgggcgac ctcaatgaca atgcgccacg 21360 ggtgctgtac cccgcgctgg ggcctgatgg ctccgccctc ttcgatatgg tgccacgcgc 21420 cgcagagccc ggctacctgg tgaccaaggt ggtggcggtg gacgcagact caggacacaa 21480 cgcttggctg tcctaccacg tgctgcaggc cagcgagccc gggctcttca gcctggggtt 21540 gcgcacgggt gaggtgcgca cagcgcgtgc cttgggcgac agggacgcgg cccgccagcg 21600 cctgctggtc gctgtgcgtg atggaggaca gccgccactc tccgccaccg ccacgctgca 21660 cctaatcttc gcggatagcc tgcaagaggt attgccagac ctcagcgacc gccctgagcc 21720 ctctgacccc cagacggaac tgcagtttta cctggttgtg gccttggcct tgatctcagt 21780 gctctttctc ctcgcggtga ttctagcgat cgccctgcgc ctgcgacgtt cctccagcct 21840 cgacactgag ggctgctttc aaaccggtct ctgctccaag tctgggcccg gggttcctcc 21900 caaccacagc gaggggactt tgccctattc ctacaatcta tgtattgcct ctcattctgc 21960 aaagacagag tttaattctc tcaacctgac accggaaatg gctccccctc aggatctgct 22020 gtgtgatgat ccttctatgg ttgtatgtgc cagtaatgaa gatcacaaaa tcgcttatga 22080 cccttctttg tcttcgcacg tgagtttctg caaatctagt taaattttat atatggcggc 22140 cgggcgcggt ggctcaagcc tgtaatccca gcacttaacc aggctgaggc aggtggatca 22200 cttgaggtca ggagtttgag accagcatag ccaagatggt aaaacccggt ctactaaaat 22260 tacaaaaatt agttgggtgt ggtggcacgc gcctgtagtc ccagttactc aggaagctga 22320 gacaggagga tcgcttgagc ccgggaggtg gagattgtag tgagccaaga gtgtgccact 22380 gcactccagc ctgggtgatg ggagggaaac tgtctaaaaa aacaaacaaa caaaaattat 22440 atattgcatt ttcttctcat tggtgtataa gtaattttga ttttctttca ttgttctagt 22500 gatggtatct actgcgggag ggggtactag atagatggag attgctttct tgattgctca 22560 gtagtcttgg caatttaatt ttcaatcttt actgttggca tttctgtatg gttggcaaat 22620 cttgctaaag agacctgttt cctagatgtt aacacttagt aatagcagtg ccttttctta 22680 gttgatatgc aatactatat tttcaagtca ttttattctt agctctttat aaatgtattt 22740 agagttcttc ccacccaagt taaagttcat caattacatt aattatgtaa ttgatgtaat 22800 tatgtattaa tgtaattatg taattaatgt aatcttcatc aattacattc tagtttgtct 22860 ttttgcagca acatgtatgt ttaatacagc cttccaatta ttaagactct taacactttg 22920 tctcatcaca agtagcaaat attgtccaat tttatatttg catcactaac tttgagtcaa 22980 tattattccc actctataat ttcagtcaat gatatttcat aattttctta accattccta 23040 aattatttgt ttttatgctc tttctatttt gtctctatta aaacaaagaa tgtaatgaac 23100 atttgggttt ataaagcgtt ttccatactt cttgtttctt tagtgtagat ttctgaggaa 23160 ttagttaaat ctataaacat gttgagattt ttttaatgca tactgtcaaa tttatttcca 23220 aacatcttat ttcacctctc aatcatccgc agtttgtgcg gtctttgagg attgtgaaaa 23280 acacgtttaa tctactctct caaagtctga gggtttttaa attctgtata gctaatgccc 23340 ttttgtatga gtcatttcta ctgctaattg ttaagtgagg aataagctta agaactgatg 23400 tactgcttta tctcaaattt tcacagatta gtaaattact gtaagtattc ataagaaaga 23460 aagcgatggc acatgcaatg ataatccatg ttcggctacc aaaacatttc cttttactgg 23520 ctatttctaa aatgagagct aaagtaaagt tagaaattgt aaaataatac tgaatgtgtc 23580 atgtgaaaaa atcactaaac tattatctgc actttatagt tattcagtct aacttttctt 23640 tttatttctt ttttattttt aagatcagag ttatttaccc attgttttag gctttgcatt 23700 tgaactggtc attcatgaaa cattgaaagg tttcataaaa attactactc tatgaaaggt 23760 attgttctaa agattgagaa cacattgtga acaagatagt catatgcata gcttgtggcc 23820 aagaatctac tgtacacaaa attaaggagc aaattctctt cccaaaccta ttatcctatt 23880 tgtcaatctc atttgtacag ggtaaggcta actcttgaac agtaggtgag ttttttgcaa 23940 gggaattgaa gcattgcccc aggttctaga gggtcaactc ctgtgaggaa acttgttact 24000 gcataaattg ggactaaagc cagacctcca agttcctgtc ccactgtctt ttcacttatc 24060 tgtctcatcc atttttcaag tccacctttg tctttaggag agataattat gtccctcaca 24120 caatacgcta tactgagaat gggctgtggg gatgaacaat gtgaaaactg aaaagaggaa 24180 gaacacatct taggaaaaaa atcgtcatat tttctctaag aaaataaata acttcataaa 24240 gtttattgta caggaagact tggatcattc ttgaattttc attgcaaatc aaaaacagga 24300 atttgacttt attatcttgg gagaaatagg aatagaaaag tgtataaaaa ataaactttt 24360 tttaaccaag aataaattgc agtaacaggt taagactctg ggtgtcgctg ttcaccaatc 24420 agggggaaaa gacaaaccag aaatttaatc agaatcacaa gatttctgca gcacaaagca 24480 ctggctctgg agctttatga aagcttcaag cggaagccct gagagctctg gctgtgaatg 24540 cactttattt tggacccaga agatcctggg gctcctcagg cctcgacaga gggaaaaccg 24600 aagcacaggc gactccgcgg cggggttgta atggcggcgc ctcctgctcg cccagaccac 24660 acccggctgc tccagatctg ccttctcctg ggggttctgg tggaaatcag ggccgaacag 24720 attctctact cggtgtttga ggagcaggaa gaaggctcag tggtgggcaa catcgccaag 24780 gacctggggt tggcgccccg ggagctggcg gagcgcggag tccgcatcgt ctccagaggt 24840 aggacgcagc ttttcgccct gaacccgcgc agcggcacct tggtcaccgc gggtaggata 24900 gacagggagg agctctgcga cagatctcca aactgtgtga caaacctgga gattcttcta 24960 gaagatacag tgaagatttt gcgggtagag gtggaaataa tcgatgttaa tgataaccca 25020 cccagttttg ggacagaaca gagggaaata aaagttgctg aaaatgaaaa tcctggggca 25080 agatttcctc ttcctgaagc ttttgatccg gatgtaggtg taaactccct gcagggttac 25140 cagctcaact caaacggtta cttttccctg gacgtgcaaa gtggggccga tgggattaag 25200 tacccagagc tggtgctgga acgcgctcta gatcgcgagg aagaggcggt tcaccacctc 25260 gttctcacgg ccttcgatgg aggtgacccg gttcgctctg gcactgccag gattctcata 25320 atacttgtgg ataccaacga taatgctccc gtgttcactc agcccgagta ccacgtaagt 25380 gttcgtgaga acgttcctgt aggcactcgg ctactcaccg taaaagccac tgatccagat 25440 gaaggagcca atggagacgt gacgtattct ttccggaaag taagagacaa aatatcacag 25500 ctatttcagt tgaattctct gagtggggat ataacaatat tggggggtct agattatgag 25560 gactctggat tctatgacat agatgtagaa gcccatgatg ggcctggtct ccgagctaga 25620 agcaaggtac tggtgacagt tctggatgaa aatgacaacg caccagaagt cacagttaca 25680 tctctcacca gctcagtcca ggaatcttct tccccgggta cagtaattgc acttttcaac 25740 gtgcatgaca gtgactcagg aggaaatggc ctagtcacat gttctattcc agataatctg 25800 ccattcacac ttgaaaagac ctatggaaat tattatcggt tgttgacaca cagaacactg 25860 gacagggaag aagtctcaga atataacatc actgtaactg ccactgacca gggaactcct 25920 ccactgtcta cagaaactca tatttcactg caagtgatgg acatcaatga caacccaccc 25980 actttccctc atgcttccta ctctgcttac attcctgaaa acaaccccag aggagcctcc 26040 atcttatcta tgactgctca agaccctgac agtggtgaca atgcccgaat cacttactcc 26100 ctggccgaag acaccttcca gggtgcacct ctgtcctcct atgtctccat caactccaat 26160 acagggatcc tatatgctct ttgctccttc gactatgagc agtttagaga cctgcagctg 26220 ctgatgacag ccagtgacag tggagaccct ccactcagca gcaatgtgtc actgagcctc 26280 tttgtgctgg accagaacga caatgtccct gagatcctgt accccacctt ccctactgat 26340 ggctccactg gtgtggagct ggcaccccgc tccgcagatt ccggctacct ggtgaccaaa 26400 gtggtggcag tggacagaga ctcaggtcag aatgcctggc tgtcctacag cctactcaag 26460 tccagcgagc cgggactatt tgcagtgggg ctgcacacag gcgaggtgcg caccgcacgg 26520 gccctgctgg acagagacgc gctcaagcag aggcttgtag tggtcgtcca ggaccatggc 26580 cagccccctc tctcggccac cgtcacactc actgtggctg tggccgacag catcccagat 26640 gtcctggctg acttgggcag cctcaagcct tcagcagacc cagacgactc gggcctcaca 26700 ctctatctcg tggtggcagt ggccgctgtc tcctgcgtct tcctggcttt tgtcacggtg 26760 ctgctagcac tcaagctgag acgctggcac aagtcacgcc tgcttcacgc tgaaggcagc 26820 aggttggcag gtgtgcctgc ctcgcacttt gtgggcgtgg acggggttcg ggctttcctg 26880 cagacctatt cccacgaggt ctccctcacc gcggactcgc ggaagagtca cctgatcttc 26940 tcccaaccca gctatgcaga cacgctcatc agccgggaga gttgtgagaa aagcgagcct 27000 cttctgataa ctcaggattt acttgaaaca aaaggagacc ctaatcttca ggtgagtcaa 27060 tcttataata gatcatacca cactgaaata tagacaaaga gttgtgtaaa tgtctctcat 27120 tttatatgta atatatcaaa taaagttgcc tcttttaata ttttattgct ttaaagaaaa 27180 ctggtggatg accttccaat aatgatcaac agtatttacc acacaaaaat gttgtttatt 27240 acttatcctt tttggtcttc attcagttgt agtttcagcc agaattttct aattttacaa 27300 ctctgagcca cctcatttcc ttaaatttcc ttttctgtgc tgggtgtggt ggctcacacc 27360 tgtaatccta acactttggg agtgtgagga ggacggattg cctgagctca ggagttcgag 27420 accagtctgg gcaacatggt gaaacccagt ctctactaaa atacaaaaag ttagctaggc 27480 gtggtggtgt gtgcccgtag tcccagctac cctggaggct gaggcatgag aattgcttga 27540 acctgggagg cagaggttgc aatgagctga gatcatgaca ctgtactcca gcctgggcaa 27600 cagagcaagc ctctgtctcc aaaaagtaaa ataaaataaa gtaaaataaa gaataaattt 27660 ccttttctct taggtgttcc tgaaaagata caagagacct gtaaaataga aggcaattgt 27720 gtaaattcac atttacaata ttctttctca tgaagctatt gttggatctg gactgagggt 27780 tttttaattt cctattttca cactctacca tgctttgctt gaagtttact tttccttcct 27840 tgaaagggta ttttccatta taacaggcaa cgtcaattta agaatactgg caatttgtga 27900 gtttaacttt tagatataac tttaacagga tattttctca atgaactggt atatttcaaa 27960 tattttcttg ttgctgttct gagatgcacc agaagtgact atgtgtgatt cctctggtgc 28020 actcctgtga ttatgagaaa tatttccaag ctaatttcag tcatatataa gtagattcta 28080 ggagtaactt taataatttt taaattgctt atcatgacat cactattgag actttcttga 28140 tttccaagga aaatataagt ttttggagtc ttttctcttg tcatcatgtg agcctctttc 28200 aaaggttgag ttacttgggt tctggactga tatgatttac gctgcttagt aaggtggcct 28260 catccctatt gctacaaatt gctttcagat atttctgtca tcatgtggct ctgggattat 28320 tttatatgag ggaaaatatt ttgtgtgtag gggatataca acacttttgt tctttgtgct 28380 ttcatttagg ttctgtgaga attcaaaatt catgaatgca tatgcttaca caaattagtg 28440 taatttgata actggaagtt gtagtgatag actgtggaat atgcctcaat ttgacttaca 28500 aaggagagtt ttagtttcta catggttttg tattcataga aagttgtggt gcaatacata 28560 gagtaagctg gaatatgata tgatgcagtt acctggcttg gggagcagaa agcagaaata 28620 acaagtgaat gttgagagac aacttacatc tgaggagaga ttgtttaaag taattaagcc 28680 ataaaatata atttggaaat gctcaattgg tctgaaactg tgtcaagcat attcaggtgt 28740 tggcattagg aatatattcc agaatgagag tgccacatgt tttaaaggcc taggaaagca 28800 gtagataatt tataacctaa aatcaaattt tttaaaaaat gtgtttttgt tagaatgggc 28860 agtgggtttc ttttagcaaa taacaatttt gattaaacaa attgttgtat attcatatta 28920 cggactacta gataactata ttatgggcca ctagataact ataagaaata aataggaaag 28980 ctctctatgt actgatatga tctttaagat ataacaacta aaaaagcaat gtgcagaata 29040 tggtatgttg tatgcttaca tttgtgtaaa gaaggagaca gaatatttat aaaaatccgt 29100 tgccctatac aagacatatc tccggaagga tacctaagaa actttaacac tcatttcccc 29160 tgtgaaagca tttctcctca tctaaagcag agatgaaagg aagaacctat gctgaatgca 29220 tcttttgaat ttggaactat atgaatattt cacatatttt aaaacaaatg aagactttat 29280 aaattaaaaa agaaaagaaa agaaaaaagt tcttagcaaa tattgacaag ccattagtgc 29340 agtttcctga gaaaacctct gagcgtcgct gttggtcaaa agaacgaaga gaagcgtttg 29400 ggagcctctt agaggggaac ttcctgcaca aaccaaccac acagagaagg ccagtataga 29460 ttcggaaaca gaaaacaaaa gcaggaaaag tgaccttagc ccggattctg ccatccccgg 29520 aaggcttatt cctcctatgg gcaaaggagc aaagggagcc agaagatgaa agcgagctca 29580 gggaggtgcg ggctggtgcg gtggctgcag gtactgttgc ccttcctgtt gtctttgttc 29640 cccggggctc tcccagtcca gatccgctat tcaattccag aggagctggc caaaaactcg 29700 gtcgtaggaa acctcgccaa ggatctgggg ctcagcgtcc gggacttgcc agcccggaag 29760 ctgcgggtta gcgcggagaa ggaatatttc acagtaaacc cagaaagcgg agacttactt 29820 gtgagtgaca gaatagaccg agaacagata tgcgggaagc agcctctgtg tgttctggat 29880 ttcgatactg tcgctgaaaa tccactaaat attttctaca tagcagtaat tgtgcaggat 29940 ataaatgata ataccccgct attcaaacag actaagatta atttaaaaat tggcgaatcc 30000 actaagccag gtacaacatt tccacttgac ccagccctgg attcagatgt tggtcctaac 30060 tcactacaaa gataccacct taatgacaac gagtactttg atctcgctga gaaacagact 30120 ccagatggtc gtaaatatcc tgagttgatt ctaaaacact ctctggacag agaagagcac 30180 agtttacatc aattggtcct cacagctgtg gatggcggag acccacctca aagtggcacg 30240 acccaaatcc gaatcaaagt cacggatgcc aacgataacc ctccagtgtt cagccaggac 30300 gtgtacaggg tcaccctgag ggaggacgtg ccgccgggct tctttgtgct tcaagtgaca 30360 gccaccgacc gggatgaagg cataaacgca gagatcacct actcctttca taatgtggac 30420 gaacaagtga aacacttttt caacttaaat gaaaaaacag gagaaatcac gacaaaggat 30480 gatttggatt ttgagattgc aagtagttac actctgagta tcgaagcaaa agatcctgga 30540 gatctagcag cccactgcag tatccaagtt gaaattcttg atgacaacga ttgtgcacct 30600 gaagttattg tgacttcagt atctactccc ctaccggagg attcgccacc aggaacagtg 30660 atcgccttga taaaaacgag agacagagac tctggagaaa atggagaagt ttactgccaa 30720 gtgttgggaa atgccaagtt tattttgaaa tcttcctcaa agaactatta caaactagtg 30780 acagacggcg ctctggaccg ggaggagatc ccagaataca atctcaccat cacagccacc 30840 gacgggggca agccgcccct ctcctccagc ataattgtca ccctgcacat ctccgacgtc 30900 aacgataatg ccccagtttt ccaacagact tcctacatgg ttcacgtggc agagaacaat 30960 cctcctggcg cctctatcgc tcaaatcagt gcctctgacc ctgacttggg ccccagtggc 31020 caagtttcct actccatcgt agcgagcgac ctgaagccgc gggagatttt atcctacgtg 31080 tccgtgagcg cgcagagcgg ggtggtgttc gcgcagcgcg ccttcgatca tgagcagctg 31140 cgcgccttcg agctcacact gcaggcccgc gaccagggct cgcccgcgct cagcgccaac 31200 gtgagcctgc gcgtgttagt gggcgacctc aatgacaatg cgccacgggt gctgtacccc 31260 gcgctggggc ctgatggctc cgccctcttc gatatggtgc cacgcgccgc agagcccggc 31320 tacctggtga ccaaggtggt ggcggtggac gcagactcag gacacaacgc ttggctgtcc 31380 taccacgtgc tgcaggccag cgagcccggg ctcttcagcc tggggttgcg cacgggtgag 31440 gtgcgcacag cgcgtgcctt gggcgacagg gacgcggccc gccagcgcct gctggtcgct 31500 gtgcgtgatg gaggacagcc gccactctcc gctacggcca cgctgcacct aatcttcgcg 31560 gatagcctgc aagaggtatt gccagacctc agcgaccgcc gggagccctc tgacccccag 31620 gcaaaactgc agttttacct ggttgtggcc ttggccttga tctcagtgct cttcttcctc 31680 gcggtgattc tggcaatctc cctgcgcctg cgactctctt ccaggtcaga tgcttgggac 31740 tgttttcagc ctggtctcag ctccaagcct ggacctgggg ttctccccaa ttacagtgag 31800 ggtacattgc cctattccta caacctgtgt gttgcctcac aatcagccaa gacagagttc 31860 aattttctga acataacccc ggaattggtt cccgcgcaag atctcgtctg tgacaatgcc 31920 tcttgggaac aaaatacaaa tcatggagcc gctggggtcc cttttgcctc agatactatt 31980 ttgaaggtga gctttaatta atttattttc acttctggtt ttattgtttc acctaatttg 32040 ggtaggaagt tccactgcgt atttctttgt ctgtgagtta gatttggcca atgttgtgcc 32100 ttaattgtct taatcttatc taactgaatt ttaagtgttt tctctctgaa gtgtgagatt 32160 tatttaccca tgattgcaaa cctttatcac atgagatatt gcactgtatt tctttttctt 32220 cctcatcttt acattacttc tctctgcaga tttgttgcta ttgagacttt aggcaattag 32280 tttcaccttc aggctctttg ttattcaaat tttagtttta cttcctctta gaatcataat 32340 acttcagagt aaagagagtc ttcattttag taggctttgg aaattgggaa acaaagaaga 32400 aagacttttg cataatggca tggcttgtta atcacagggc atgggtagga cattgtccca 32460 ttgacttgaa gaccaacact cagtaagcta aatgtcttgg aatcacaaat gtatttctaa 32520 aggacaggca atgtttgagg tctgaggtgt ctgctagaaa gagtgcattt aacaaatgtg 32580 agaaatcatt ctctaacatg cattttaaca aattgctctt aagaaaaact acacattgag 32640 aaaaatctta caacctatgt tcacatcatt ttctacaaaa tattacttaa aactttgctt 32700 ttgaatttcc taattatata gaatttttat tttcttagtt ttctatgaaa gtgttattaa 32760 ataaaatgac tttctgaaat gtccattttt ttcaatcaag aggtttttct atttctgttg 32820 tcatataaag atgatagcag taaatatctg tctcaacata gaaaggtcac tcagtacttc 32880 tcgacaagta tctgctcatg ctttcctgca tggatgatga aataaaaccc catcctccac 32940 agttactata ctggttgtca ctggaactac aaatatttga acatggtaat agaaaaacat 33000 aaaaatgcat agttaaccca actcaaacgc tgtctgagat agtggagaga ctttctcaaa 33060 gtcctcacaa gtaacaaaga tctttatttc ttctgcatat gacagctaat ataacttaca 33120 taaatcagta ggcctgtttg gaaaggtgca tggagaactg ggtttgtttc cttggtattc 33180 ttatatgcaa ataagcacgt tttcctaaat ttatcctaat aaggagatga aatcttgaat 33240 cctacaaagg taagaatttg aatgtcctaa tttaatggac taaatataga taagaggtaa 33300 ataaaggaca taggctcccc cgatgacgca ttaaataaaa tttttgtaag gtattgagat 33360 ctaataatca tattgatctc agggattgtg gaagtcttgc tattcagaat taaagctgaa 33420 ttaacggtca taaacaacgc tacacagtta aacattaagg atatggcaac attattagaa 33480 ataaaattat aactaaactt aggagaaata aaaatggaat ttgatgcagt cactggttag 33540 gactctgagt gtcgctgttg accaaagtgg gaaagaagct gccgcagagg cgacccgact 33600 ctgctccctc catactaaac acacagacca gacaagctcc tacgaaaagc caacgctcca 33660 cgcccatttt cgtcagggaa tatgtaccca tcggctttag ataaataagg aaacagcagg 33720 ctgaaccaga actaagagaa aattgggcag agagaaggca atggcgagtc cacctagggg 33780 ctggggctgc ggagagctgc tgctgccctt catgctcctg gggacgctgt gcgagccagg 33840 atccgggcag atccgctact cgatgccgga ggagctggac aaaggctcct tcgtcggcaa 33900 catagccaag gaccttgggc tggagcccca ggagctggcg gagcgcggag tccgcatcgt 33960 ctccagaggt aggacgcagc tttttgccct gaacccgcga agcggcagct tggtcaccgc 34020 gggcaggata gaccgggagg agctctgcgc tcagagccca ctgtgtgtgg tgaactttaa 34080 catcttggtt gagaacaaaa tgaaaattta tggagtagaa gtagaaataa tcgatattaa 34140 tgataacttc ccgcgtttcc gggatgaaga gttaaaagta aaagttaatg aaaatgcggc 34200 tgcagggaca cggttagtgc ttcccttcgc gcgggatgcg gatgtgggtg tgaactctct 34260 ccggagttac cagctcagct ccaatctgca cttctctctg gatgtggtaa gcggaactga 34320 tggacaaaag tatccggagc tggtgttgga acagccccta gaccgcgaga aagagactgt 34380 tcacgacctc ctcctcacag ctttagatgg cggagacccg gtactctccg gcaccacgca 34440 catccgtgtt acggtcctcg acgcaaacga caatgcgccc ctgttcaccc catccgagta 34500 cagcgtgagt gttccagaga acatacctgt gggcactcgg ctgctcatgc taaccgccac 34560 ggatccagat gagggaataa acgggaaatt gacctactct tttcgcaatg aagaagaaaa 34620 aatttcggag actttccaac ttgattccaa cctgggggaa atctcaactc tacaatcact 34680 ggactatgaa gaatccagat tctacctcat ggaagtggta gctcaggatg gaggcgctct 34740 tgttgccagc gctaaggtgg tggtcacagt acaggacgtg aatgacaatg cccccgaagt 34800 gatcctcacc tctctgacca gttcgatctc tgaagactgt cttcccggaa ctgtaatcgc 34860 gctgtttagc gtacatgatg gtgattctgg agaaaatggt gagattgcat gctctattcc 34920 taggaatttg ccttttaaat tggagaagtc agttgataat tactatcacc tattaacaac 34980 tagggacctg gacagagaag agacttcaga ttataatatc actttaaccg tcatggacca 35040 tggaaccccg cccctctcta cagaaagcca catccccttg aaagtagcag acgttaatga 35100 caacccaccc aatttccctc aagcctccta ctccacctct gtcacagaaa acaatcccag 35160 aggtgtctct atcttctctg tgacagccca tgaccccgac agcggcgaca acgctcgagt 35220 cacctactcc ctggctgaag acacatttca gggggcgccc ttgtcctcct atgtatccat 35280 taactctgac accggtgtcc tgtatgctct gagatccttc gactatgagc agttgagaga 35340 cctacagttg tgggtgacag ccagcgacag tgggaaccct ccacttagca gcaacgtgtc 35400 gctgagcctg tttgtgctgg accagaacga caatacgcct gagatcctgt accccgccct 35460 ccccacagac ggttccacgg gcgtggagct ggcgcctcgc tccgcagaac ctggctacct 35520 ggtgaccaag gtggtagcgg tggacaaaga ttcaggccag aacgcctggc tgtcctaccg 35580 cctgcttaag gccagcgagc caggactctt tgcggttggg ctgcacacgg gcgaggtgcg 35640 cacagcgcga gccctgctgg acagagacgc gctcaagcag agcctcgtgg tggccgtcga 35700 agaccatggc cagccccctc tgtcagccac cttcacggtc accgttgccg tggccgacag 35760 gatccctgac atcctggctg acctaggcag tatcaagacc cccattgacc ctgaggatct 35820 ggacctcaca ctctatcttg tggtggcagt ggctgcagtc tcctgcgtct tcctggcctt 35880 cgtcatcgtg ctgctggtgc tcagactgag gcgctggcac aagtcacgcc tgcttcaggc 35940 tgaaggcagc aggttggcgg gtgtgcccgc ctcgcacttt gtgggcgtgg atggggttcg 36000 ggctttcctg cagacctatt cccacgaggt ctccctcacc gcggactcga ggaagagtca 36060 cctgatcttt ccccagccca actacgcaga cacgctcctt agtgaagaga gctgtgagaa 36120 aagcgagcct cttctgatgt ctgataaggt agatgcaaac aaagaagaac ggcgagttca 36180 ggttagtttt ctctttcggt aaggatgacc agaacatttt catttgtttc ctttttcatg 36240 tttctgtcat attcagaatc agctagttat gtaaatagtg gaacattatt tgctgtattg 36300 gagattaatt ttttttatat aattcatgct ttctccattt gttttcaaat tctgttttgg 36360 gaagtctagc tgatatctgt agacttaagt gaaacaaata ccttaaagga aagtggttaa 36420 atataatcat tttacccaaa tattttgtta tattggaact gcagttctat taatagaaaa 36480 gatgttttat ttattcaaat tgttagatat attgttctct tttgagtgtc tgcctagaca 36540 ccattagtga atgtgttttg gaaaggataa tgtataggac tgatatttta gtctacctga 36600 aatttgttta aggaaataat ttacagtatt tacataaatc agtggaaagg tacagagaac 36660 ttctgggtca taaatatcag aaaagaggcc gggtgcggtg gctgacgcct gtaatcccag 36720 cactttggga ggctgaggtg ggcggatcac gaggtcagga gatcgagacc atcctggcta 36780 acacggtgaa accctgttct actaaaaata caaaaaatta gccgggcgtg gtggcaggcg 36840 cctgtagtcc cagctactcg gaaggctgag gcaggagaat ggggtgaacc cgggaggagg 36900 agcttgcagt aagccgagat cgcgccactg cactccagcc tgggagacag aacgagactc 36960 cgtctcaaaa taaataaata aataaataaa taaataaata aatatcagaa aagtagataa 37020 aatttatatt aatgataaca tgtagcattc taaagtctgg aaagtttgtg ttaagccatg 37080 tagttattgg atatgtgggc ttgttgagag aagaaatcag tgtaaaggaa ccttaaggtt 37140 gggcttcgtt ctgtgatgta aagcctccag agagttacat actgctgcac tcaataaatg 37200 taaatatgtc acacacctgg catcttctgt tatagataaa ccctttactt attagaatca 37260 atacctactg caatgttagc gtttctttaa gtgtaggtgc aattcttctt tattacttga 37320 gtttaaggtt gtatttgaaa aaaaaagaac tcaacttaaa gatggttcaa aattttaaat 37380 ttcatatcta acgtatgtgc tcatcttaaa ttaatagatt tgtcttaatg aaatactggc 37440 ctatgtgcct caaattccag gaggatgtgt tatgtaatga aagaactact atatttccct 37500 tctgcatctg atttgctgaa gatgattttc agatgtttct tattaaaata ttcttaatcc 37560 ttcaaatttt gtacttttaa aaccttgagc atcagcttca aataatgact aaataagggg 37620 aaaaggtaat aaaatattac aaatgggata gtaagctaca ttactcaacc acatgaaagg 37680 ttaattgaca cattaaagaa cctaagacca cttgattttt attttttaaa cactgttaaa 37740 gagcattcaa gtatatctat atctatatac atatacacac acatatatat acacacatat 37800 atatacacac atacacacac acaaacacac atacatacac acatggacat tctgaccaaa 37860 atgtaaaatg tacaaactca ccgaatagtg aatgcatcca aagagtaaca agagaatcta 37920 tacagtaggt gtcgacatta ttcactccta tgtgaaaact tgcttttcca ttttttttaa 37980 aagaaaatgt tatatgcttc ttagggtaag gtgtttggga aaaaagtaaa ggttatagat 38040 ttgggtacat ttcttctgag ttaaatgttt tgtgcaatgg aaaaatatct ttaaaccctc 38100 tataaactac taacagacta taaaatgctt gatccataca ttttgaatgt atgtactgta 38160 tataccatat acttttaaat atctgaatct ttagttttat atgtgttctg aagaataatt 38220 tttcatacta attgaagtgt tcatacaatg aacacttggc attgtgttgg aaggcacttg 38280 ctttggaatg ttttggagca aagtcttgag tcagttatat ttttgatgtt tgtataaagg 38340 tgacaatgag tgtctgtcta gaattctggt tactgtgagt agtttaagat gctataatgc 38400 ttttccacta taaggtgaat tcggtgtgga actcattgct tattgctgca cacttgccta 38460 gttttagagt aacaatacat tatgtaggct aaagataatt tctttaggaa gattttctgg 38520 tttgaaaatg gaattaaaac tgtaagacac ctgtcagaaa catggaaaat ggcatgttat 38580 tgaccaggga aaagtgtaaa taacaaaaag ttaggattat cagatggtaa actggggacc 38640 aaggaaaagt ggacaggaag attacttata taattaaata atataattat aaggacttac 38700 aattcactcc ccaatcctaa taacgcatca ttgttaggct acttgagaag aaacagtaca 38760 tttcaggaca attgtgatgt agtatgaaaa aacatccttt gtaaaagttt ttcatttggg 38820 ccagggtggt tcatgactat aatcccagca atttgggacg ctgaggtggg aggattgctt 38880 aaagccaggt gttctagccc agcctgggca acatagtgaa accccacctc tatagaaaaa 38940 aaaagttttc aatcatactt atttaattaa aagtagacac ttggaaacaa aggaaaagag 39000 accctcttgc tttttactat acttctattt tataaggtca atcatttcct cattaccttt 39060 aacttctttt ggggggagat aataaagata aaagagaaga aagtgaaaca tagaataaaa 39120 ctaaaagcta tgacattata acttttagaa gttagaagta aaggaaatag aatgcaataa 39180 gaatacacgt gaagctgata tttcaagcct ctttatacta cgtcttctgc catcaccaaa 39240 aatagcttcc atttgtatga ttttctatgt attattttat ttggccctca tttctactag 39300 agtaagcaga gaagatatta ttatgaccat tttatgaaaa tggaaactaa aaacgtgacg 39360 ggattgagca agattatctc tgccctttga caagtaaaag gtacttgatt tggatggata 39420 aagctcaaat taaaagaaat aacagactaa agatatagta agtatattta atgtttttta 39480 aaagtccttt taaaatggga agaaagtatc actatcagta cactgccgat ttttctccta 39540 actagctcct tatttggagc tgatttagtc accattactg cagttctgca gcagaggcgc 39600 cgggtgccgc tcttggctag tgctgtgcaa aatattggct cctcccgctg cagccagctc 39660 ggaagaaaag tgcactctct atcaggcttc ctgcagcgga gacacccatt agagaaccca 39720 agcacaaaga caaagcaaat agttggtcct gctcggagaa ctcttgggat tatttaaaga 39780 tctcctctcc tcggatttag aaaggcaaag gcgcagagag cgggatggga aatagctccg 39840 gatggagggg cccagcaggg cagaggcgaa tgctatttct cttcctgctc tctttgttag 39900 accaggctct ctccgaaccg atccgctacg ctattcccga ggagctggac aggggctcgc 39960 tggtagggaa cctcgccaag gacctggggt ttggcgtggg ggatttacct actaggaacc 40020 tgcgggttat tgcagagaag aaattcttta ccgtgagccc cgaaaatggg aacttacttg 40080 tgagcgaccg tatagaccga gaggagattt gtggcaagaa gtcgacgtgt gttctggaat 40140 ttgaaatggt tgctgaaaag cctttaaact tttttcatgt aactgtgctg atccaggata 40200 ttaacgacaa cccaccgacc tttagccaaa atatcactga gctggaaatc agcgaactgg 40260 ctctcactgg agccacattt gccctggaat ctgcgcaaga tcctgatgta ggtgtcaatt 40320 cgctgcagca gtactacctc agccctgatc cgcacttctc tttgattcag aaggagaacc 40380 tggatggcag taggtaccca gagctagtac tgaaagcacc cctggacagg gaagagcagc 40440 cacatcacca cctggtcctc acagctgtgg atgggggcga gccctccaga agctgtacca 40500 cccagatcag ggtaattgtc gcagatgcaa atgataaccc cccagtattt actcaggaca 40560 tgtacagggt caatgttgca gagaacctgc ccgctggctc ctccgtatta aaagtgatgg 40620 ccattgacat ggatgagggc atcaatgccg aaatcatcta tgccttcatc aatattggca 40680 aggaagtgag acaactgttc aagctggaca gtaaaacggg ggaactcacc actattggag 40740 aactggactt tgaagagaga gatagctaca caattggggt ggaagcaaag gatggtggac 40800 atcacactgc atattgtaaa gtacagatag atatttcaga tgaaaatgac aatgccccgg 40860 agataaccct ggcttctgaa tcccaacata tacaagaaga tgctgagctg gggactgccg 40920 ttgccctgat caaaacacat gatctagatt ctggatttaa tggagaaatc ctatgccaac 40980 taaaaggaaa cttccccttt aaaatcgttc aagataccaa aaacacatac aggttggtga 41040 cagatggagc cctggaccgg gagcagatcc cagaatacaa tgtgacgatc acagctaccg 41100 acaaaggcaa tccaccgctc tcctccagca agaccatcac tctgcacatc cttgatgtca 41160 acgacaacgt tcccgttttc caccaggcct cctacaccgt gcatgtagct gagaacaatc 41220 cgcctggagc ctccattgcg catgtcagag cctcggatcc cgacttggga cctaatggcc 41280 ttgtctccta ctacatcgtg gccagtgacc tggagccgcg ggagctgtcg tcctacgtgt 41340 ccgtgagcgc gcggagcggg gtggtgttcg cgcagcgagc cttcgaccac gagcagctgc 41400 gtgccttcga gctcactctg caggcccgcg accagggctc gcctacgctc agcgccaacg 41460 tgagcctgcg cgtgttggtg gacgaccgca acgacaatgc accgctggtg ctgtacccag 41520 ctctggggcc cgaaggctct gcgctcttcg atatggtgcc gcgctctgca gagcctggct 41580 acctggtgac caaggtggtg gcggtggacg cagactcggg atacaacgcc tggctgtcct 41640 accacattgt gcaggccagc gagcccgggc tgttcagcct gggcctgcgc acgggtgagg 41700 tgcgcacggc gcgtaccttg ggcgacaggg aggccgcccg ccagcgcctg ctggtcactg 41760 tgcgtgatgg aggacagcag cctctttcag ccaccgtcat gctgcaccta atcttcgcag 41820 atagcttgca agagatacaa cctgacctta gcgaccgccc cactccctct gaccctcagg 41880 cggagctaca gtttcaccta gtagtggcgt tggccttgat ctcagtgctc ttcctcctcg 41940 cggtgattct ggcaatctcc ctgcgcctgc gatgctcctc cagacccgcc actgagggct 42000 actttcagcc tggtgtctgc ttcaagactg tacctggagt tctccccacc tacagcgaaa 42060 ggactttgcc ttattcctac aatccgtgtg ctgcctcaca ttcctcaaac accgagttta 42120 aatttctcaa tataaaggct gaaaatgctg caccacaaga tcttctatgt gatgaagcct 42180 cttggtttga aagtaatgac aatccagaaa tgccttctaa ttcaggcaat ttgcaaaagg 42240 tgagtttctt caaacctttc cttccataaa tataattggg tttcaattca ttgatttaga 42300 gataaaaaga atacagatta aatattccct gattacatta ttttattgat tttctggtgt 42360 agagtagggt gtctaggaaa ttctttgtag aatttcctgt agaatatctg tgttgcagtt 42420 gttctttcat agaaagcctc cttttgatag tcttgaaact tttcttaatc ctaatacact 42480 ataatctgaa acatttttaa tacagtatta tctcacactg tcattttcag acatatctat 42540 ccagaattag acccaaatcc tcacaattaa gtggtttact tagttttaat gcagtcaatc 42600 ctaaaatata tgaaacatta tgtatatctt aacacatttt taatgtaacc tgtatataat 42660 atttttactt ccctttgcat gtttttaaaa gtatacacag atgttgccta tgtcagggca 42720 gtttttaact tctatgctaa tcaaaagaaa taatggcatc taaaatggca actcttgtaa 42780 tgggcactgt aatgaattgg ttcaaaatgt gtttgtgtag catatgcctg tagtcccagc 42840 tactcgggag gctgaggtgg gaggatccct tgatcccagg aggtagcagc tgcaatgagc 42900 tataattgtg cccctgcact ctagcctggg agacagagcg agactttgtc tccaaaaaag 42960 tgtttgtggt tgttggtacc cttactgaaa atgggactag cataaatggt ggtgaaatgt 43020 gatgataatt caaaatttac agaagattgt aatattattt ctgttcccca aggtcctaag 43080 agatattttc ataaaaatga atggtaaact tcagagaaca tttaaaatta ttcaaaataa 43140 tctcttacac tcttctaaat gcttcattat cttggggagg gaaatattat gagtgtcatc 43200 tctgcagatt tagcagaaat aaaatcctct gtgtgatagt ttcacaaaac gatgcagtat 43260 taagttagga ctctaagcgt cgctgttgac caacctgggc aagaaaatca acggaaactc 43320 aagttacatc ctccaacaac aaagcaaatt agacgggaaa gcaggaaagc tgtgcagaaa 43380 ttctgacctg aaacgcttcg catccggtct ctgcttgttg aaggaccttc accgctattt 43440 ctgagaagag caaaagtgat gcagatctgt tcttcctctt cttaatccca gagaagttcc 43500 taataagcca gtaatggcgc ctccgcagag gcatccgcag cgcagcgagc aggtcctgct 43560 cctcacgctc ctggggacgc tgtggggggc cgcggcagcg cagatccgct actctattcc 43620 cgaggagctg gagaaaggct ccttcgtagg caacatcgtc aaggatctgg gactggagcc 43680 ccaggagttg gcggagcacg gagtccgcat cgtctccaga ggtaggatgc agcttttctc 43740 tctgaatccg cgaaacggca gcttggtcac cgcgggtagg atagaccgcg aggagctctg 43800 tgctcagagc ccgcggtgtc tggtgagttt taacatcctt gtcgaggata aactgaatct 43860 ttatcccgtg gaagtggaaa tagtggacat taatgacaat acaccccgat tcttaaagga 43920 agaattggaa gtgaaaattc tcgaaaacgc agctccatcc tctcgttttc cactaatgga 43980 ggtctatgac cctgatgtgg gaatgaactc ccttcaggga tttaagctca gtggtaatag 44040 tcacttctca gtggacgtgc aaagcgaagc ccatgggccc aagtacccgg agctggtgct 44100 ggagggcaca ctggaccggg aaggagaagc cgtttaccgc ctggtcctta ctgccatgga 44160 tggcggcgac cctgtccgct caagcgtcgc ccaaattctg gtaacagttc tagatgtgaa 44220 tgacaacact ccaatgttta ctcagcctgt ctaccgtgta agtgttcctg aaaacctgcc 44280 agtaggcaca ccagtgttgg cagtgactgc caccgaccag gatgaaggag tccacgggga 44340 agtaacttat tcctttgtga agattacaga aaagatctca caaattttct gtttgaatgt 44400 tttgactgga gaaatttcaa cttctgcaaa tctagactat gaggactcga gtttttatga 44460 gctgggtgtt gaagcccggg atgggccagg tcttcgagac agagcgaaag tcttaataac 44520 tatcttggat gtcaatgata atgtaccaga agtggttgtt acatctggaa gcagaacaat 44580 tgctgaaagt gcacctccag gaacagtaat cgcccttttt caagtgttcg atcgagactc 44640 tggcctgaat ggcctggtaa cctgttccat cccgagaagt ctcccatttg aattggaaaa 44700 atcagttggc aattattatc gattagtgac aaatgcagct ctagaccggg aagaggtatt 44760 cttgtacaac atcactgtga cagccacgga caaaggaaca ccacctctgt ctacagaaac 44820 aatcatctct ctaaatgtgg cagacaccaa cgacaacccg cccaccttcc cccattcatc 44880 ctactcagtc tatgtccttg aaaacaaccc caggggtgcc tccatcttct ctgtgaatgc 44940 actggaccct gacgtggacc agaacgccca agtctcctac tcactggcag aagacaccct 45000 ccagggggcg cccctgtcct cctacgtgtc catcaactcc gacactggga ttctgtacgc 45060 cctgcgctcc ttcgactatg agcagttgag agacctacag ctgtgggtga cagccagcga 45120 cagcggggac ccgcctctta gcagcaacgt gtcactgagc ctgtttgtgc tggaccagaa 45180 tgacaatgcg cccgagatcc tgtaccccgc cctccccaca gacggttcca ctggcgtgga 45240 gctggcgccc cgctccgcag agcccggcta cctggtgacc aaggtggtgg cggtggacag 45300 agactcgggc cagaacgcct ggctgtccta ccgcctgctc aaggccagcg agccaggact 45360 tttctcagtg ggcctgcaca cgggcgaggt gcgcacggcg cgcgccctgc tggacagaga 45420 cgcgctcaag cagagcctag tggtggccgt ccaggaccac ggccagcccc ctctctccgc 45480 cactgtcacg ctcaccgtgg ccgtggccga caggatcccc gacatcctgg ccgacctggg 45540 cagcctcgag ccctccgcca aacccaacga ttcggacctc actctgtacc tggtggtggc 45600 ggtggccgcg gtctcctgcg tcttcctggc cttcgtcatc gtgctgctgg cgctcagact 45660 gcagcgctgg cacaagtcac gcctgctgca ggcttcggga ggtggcttag cgagcatgcc 45720 cggctcgcac tttgtgggcg tggaaggggt tcgggctttc ctgcagacct attcccacga 45780 ggtctcactc actgcagact cgcgtaagag tcatctgatt ttcccccagc ccaactatgc 45840 cgacacgctt atcaaccagg agagctatga gaaaagcgag cctcttctga taactcagga 45900 tttacttgaa acgaaaggag aacccaggca acttcaggtg agtttctttc cgcctaagcg 45960 ggaagagtaa tctgatcttc ccgcaaccca actaatcaga caggctcatc agctagatcg 46020 gctgttatag aagcgaacct cttttggtac aggaagattc gtgattttgt aaagtggaag 46080 actcccttgt tcaggtgagg gtatcgtttt tttttttttt tttttttgag acggagtctc 46140 gctctgtcgc ccaggccgga ctgcggactg cagtggcgca atctcggctc actgcaagct 46200 ccgcttcccg ggttcacgcc attctcctgc ctcagcctcc ctagtagctg ggactacagg 46260 cgcccgccac cgcgcccggc taattttttt gtatttttag tagagacggg gtttcacctt 46320 gttagccagg atggtctcga tctcctgacc tcatgatcca cccgcctcgg cctcccaaag 46380 tgctgggatt acaggcgtga gccaccgcgc ccggccgagg gtatcgtttt tattggttga 46440 caggaaaatt caagattgtc tttgattagt gcttagtttt cttagccctt tgcagagagt 46500 cacataattc taatgttttt cttttatatc aaaagaatgt tctgaagtct taattttgtg 46560 ggggaaaata atgcatgtcc tagtttttct ttacctttct cttcttggca aactatttgt 46620 gtcttggatt gagtacatct cgtttcttag gttttttcct actatgtgac atttgtaagg 46680 ttctttcttt ttctaatgtg ggaaaaaaaa taaccttaat ttaggtcagt gttaaagatc 46740 aagatcttgg ttttagctag catggtggtt cacgcctgta atcccacctc ttcaggaggc 46800 tgaggcagga ggatcccttg agaccaggag tttgagacca gcctgggtga ctctgtctct 46860 accaaaaaga aaaaaaagta gccagatgtg tggcgtacac ctgtagtccc agctactcga 46920 gaagctctga taggaggatt gcttaagtcc aggggtatga ggctgcagtg agatataatt 46980 gtgtcactgc accctagcct gggagacaga atgagacttt ttctctctct ctctcaaaaa 47040 aaaaaaaaga ttttgttttt tctcagtgtt acttgataac tataaacgac agacgttcat 47100 acaagagatc tttcaccttt actacttagg aatcaaaaat tatttttgaa aagataagaa 47160 tcattggtaa ctgcagcagg ggacaccaga tctttggtgt taaaagacct gaataacatt 47220 cctgtaacta tctgttattt acttgggcca gttacaatcg ccattatctt ccaattaaaa 47280 ttaagattta aaagacttct cttatcagag ataggatccc cctctgttgc ccagtctgga 47340 gtaaaaatcc acctgtaact gctgcttata gagtgtgtat ccagggcaac ttgaatctat 47400 gttcctgggt tgcaatccta aagcttggct caaataagct ctacttatat tattttttaa 47460 aacaagactt tccttatcta tctgactcaa attctaagaa aataatttta taactttttt 47520 tcaaactcta aagcagcata gtgaacacgt atttgttgac atcaccatta ttataattat 47580 tgggttgtta acaataacta agcaccgatg ctgtgtgcct actacagtgt cttttgcata 47640 ctgtgtgcct gatagtattt aagagtgaaa atggccgggt gcggtggctc atgcctgtaa 47700 tcccaacact ttgggaggcc aaggcaggca tctcacgaag tcaggagttc gagaccagcc 47760 tgaccaacat ggtgaaaccc cgtctctact aaaaatacaa aaattagcca ggtggggtgg 47820 catgggcctg taatcgcagc tactcgggag gctgaggcag gagaatcgct tgaacccatg 47880 aggcagaggt tgcagtgagc caagatcgtg ccactgcact ccagtctggg tgacagagcg 47940 agactctgtc tcaaaaaata ataatgataa ttaataaata aagagtgaac atgaatttta 48000 aaacatgctc ggtagtgtct gcttacagga catatctcta aaaatagatg actgactggt 48060 gaatgggaga acaaatgtta atgaggttca aataaaaatt taaatatttt agcattttaa 48120 cccagacaat aaggctttca tcatatagga actctttatt gaaatatttc aagaaaaaag 48180 ggattatcat ttagaagact gattagtctt atttattatg actgaaatgt gcaaacagaa 48240 tcattgtttc atgaacagaa aacagcagag tttttgactg tcaatgatgt tcgaatagaa 48300 aatggatcac taaggagata ggagattctg ttatcgacag tcttcaaaag taagttgatg 48360 gccctggaat gaatggagta caggggattc tctaatttga tgacttgttg aactacatta 48420 tagtcaagat ttttctccag tcatgagttg gaagattcta caatctggtg gtattataga 48480 atggattggc cacttgtgca tctgaatttg ttatgaatgt gtaagaaaaa agcaattgag 48540 aagatacctt gaaaataaat gagaacctcc tttgtaacct gactttgtca gtcttcttaa 48600 agataacatt gagttgatgt gtttttaaat aagctgctaa gagtaatatg tgtttttctg 48660 aaccaatatt gtggtattta catttaagga attgttatag atttatttat ttcaagtttc 48720 caaaggtata tacctaaaca agagatctaa tcatacacat cttcaaagct cattttcttg 48780 tatctttgtg atataatttg ataaaataac aattttaaac aacttgaatc ttggatatta 48840 gtctcatgag ttagatgggc tgttatacat atgattattt cataaactct gaaagtgtga 48900 atgttatttt actatactac caatttggga tgttaaacta catcttgagc atttgttgtt 48960 atagggaaag ctcactaact acttttcatg gagatcaggc tggtttattt tattctctta 49020 ttacctgtga ccatttcatt taaacaaata aaatatttct ctgatggaaa aactaccaac 49080 ttctactctc acaaaagtca ttcactcatg tggactgacc aactgttaaa catcctggca 49140 gtcatggaat ttgctaagtt atggctaaat gaggttcttt aatccacctg caatacagat 49200 cattaataat aagataggct atctgaggtt ttgagagttc agtatagaat tttgaagcat 49260 caggaaaaaa aactaccaaa ttattgtctt attcttattt tatggtctgt gaaagcctct 49320 tttttttttt tttttttttt tttttttttg tcagagtctt gctctgtctc ccaggctgga 49380 atgcagtggt gtgatctctg ctcactgcaa cttcctcctc ctgggttcaa gcgattctcc 49440 tgcctcagcc tcccaagtag ctgggattac aggtgcatgc caccatgcct agctaatttt 49500 catactttta gtagagatgg ggttttacca tgatggccag gctggtctca aactcctgac 49560 cttaagtgat ccacccgcct cagcctctca aagggctggg attacaggca tgagccactg 49620 agcccggcct gaaaggcatt catttctgat caggcttctg ttgaggtggc aattgtcaaa 49680 ggggaaggag taaaatctca gaggagaaac attggaagat acctatatct ttgcttgaga 49740 atgaaaatct aaatggaact tcaaagaact gttttgttgt ttgtttttta gaaaaaaaag 49800 tcccaaaaaa gaaaagagag aagataatca attcgatgcc caggaagcca aatagacttt 49860 acatagaatt ctttttaatg caaccaaaca aatggtcagg attcttccca atatctcagt 49920 caacaataat atacactctt taaactatga aatgatttca atttgataca atgagcttat 49980 gttagatttt attaaacata tcttggcggt ctagtaaaga tctttaatat ttaattttat 50040 gatgttcgat aacttagaaa atgtgaatgc tagagacaat gaagccattt actccatagg 50100 gtatgtatgc tttgtgttcg gagtagtcta taatttaatt taactagctc ttatttcctt 50160 ttctccaaag aaggtaccaa gacactataa attaattgag acttttttaa aacagtagaa 50220 taagaaacaa atgtgagatg aaactatgaa ttttgaggca tcaggtaaaa atggatcaag 50280 acattgagag ctataacctc caaacatgaa agtttgtttg aaaatatcta caagtgctta 50340 cattgtttaa taatcataca ctttgcttgc ctcaacaaga agttcaaaag tactattaaa 50400 caaatagaat ttaactccag tttacagaat tcatctataa tacctctatt agttccttta 50460 aacaaaattt atctactttg tgaatgcaaa gataactatg gattattttg atagatcaaa 50520 acagaatgtc cttcaaagtg ttccctgtat tctggagcaa tgccaccaga aagcagaaat 50580 aggttactta ggagcctccc acaaaacgaa gttaagcttt cttagtgtta gttctggatt 50640 ctcctcctgg ttccaccaac tactctccag gacctagaag aatttacaaa ccaagactgt 50700 ttcttgccag gtctttattc cagagcaggt cattctcttt tattctgcaa ctatgtgaaa 50760 ggagctttct tttctttctg ctagcagagg gtagcctcgg atccatcaat aatttagttt 50820 tactctatca acatcagtgg agagacgagt acctctaagg atcctgtcag gacagtcctg 50880 cattttgctc aaatgctgtc tagagatccc tgttttctca attacactag aatagagtag 50940 gatgaagatt tgaattgcat actaggatga agacttgaat tgaattgcat aatgaaaaga 51000 atcagccaat ccattatcca gtttcttatg aattcacagc ccagtaggat ctctgcagat 51060 ttctgccttc tgtagaaaat gggttgcttc tatagctgat tgctgcagcc aagacaaaca 51120 acgatttctt tctttttttc tcacaagact gggagtgaga atatttggat tccgacattg 51180 ttctactact atataatcaa taatcaggaa caaggcaagg caattccctc tttctttctt 51240 tctttctttc ttcttctttt tttttttttt ttttttttgg cagagttttg ctcttgttgt 51300 ccaggctgga gtgcaatggt gtgatctcgg ctcaccacaa cctccacctc ccgggttcaa 51360 gcgattttcc tgcctcagcc tcctgagtag ctgggattac aggcgcgcgc caccacgccc 51420 ggataatttt gtatttttag tagagacggg gtttctccat gttggtcagg ctggtctcaa 51480 gctcccgacc tcaggtgatc cgcccgcctc ggcctcacaa agtgtgggat tacaggcgtg 51540 agcaacagca cctggccccc cctctcattt tttaaacggt taaaatgaag gtgttagacc 51600 gtctctaagg ttctatacaa tcaaaaattt attaaaatag gtctatatat tttacaacaa 51660 ttttgacttt ctgaatcttg catcatggtg tctagaacat atgtgttcaa ttaatactga 51720 attaattaaa atttatatac actgatgtaa atattttcta agtaaaatct ttcatatgta 51780 tttaaataaa atttaccttt ttgccttcaa taactgattt tcccatgtgc aataacgtgt 51840 gagtcagtgc ccaaaagagt cacttgaaag ttgcaaggca aagcagtttt ttaaaaatta 51900 tctaagatta tcaaacaccg gtccatgaac actgttgcat taattcagtg tcttaaaatg 51960 gatttttaat tatcagggat atctagagca aagaaatcta acagggaaat tttgaaagat 52020 gaaacaattt tctatgaaat cagtgtattg tgtgcatcaa tgtggtgcag taacttagta 52080 aggactcaca gcgccgctgt tcaccaacca gggaaaaatg gtgcgagaga tcccacagaa 52140 accaccgagt tttacagcac agagaaacga cagattgcga taagccctct tccaggctgc 52200 actaaactca agcctctatc ctgctggatt ctgagctccc cttcctaaga cagaggggtc 52260 cacccggata cacccgcatt ctgaagcact tcccgagatc ggcgcctaag caagagaagc 52320 aggacgacta tggcggctca gccgaggggc ggggactaca gaggattctt cctgctctcc 52380 atcctcctgg ggaccccctg ggaagcctgg gcaggacgta ttctctactc cgtgtcggag 52440 gagacggaca aagggtcctt tgtgggagac atcgccaagg acctggggct ggagccccgg 52500 gagctggcgg agcgcggagt ccgcatcatc tccagaggta ggacgcagct tttcgccctg 52560 aaccagcgca gcggcagctt ggtcactgcg ggcaggatag accgggaaga gatctgcgct 52620 cagagtgcgc ggtgtctggt aaactttaac atcctgatgg aagataaaat gaatctttac 52680 cctatagacg tggaaataat agatattaat gacaacgttc caagattctt gacggaagaa 52740 ataaatgtaa aaataatgga gaatacagct cctggggttc ggtttccgtt aagcgaggct 52800 ggggatccag atgtgggcac gaactccctc cagagttacc agctcagccc caatcgccac 52860 ttctccctgg ctgtgcaaag tggagacgat gaaactaagt acccggaact ggtgctggag 52920 cgggtgctgg accgggagga agagcgggtt caccacctgg tcctcacagc ctctgatggc 52980 ggcgacccgc cccgatccag caccgcccac atccaggtga cagtggtgga tgtgaatgac 53040 cacacgcctg tcttctctct gcctcagtac caagtaactg tccccgagaa tgtgccagtg 53100 ggtacaagac tgctcacggt acatgctatc gacctggacg agggagtcaa tggggaagtg 53160 acatattctt ttcggaaaat aactcctaaa cttccaaaga tgtttcatct gaactcgctt 53220 acaggagaaa tatcaacttt agaaggatta gattatgaag aaactgcctt ctatgaaatg 53280 gaggttcagg ctcaagatgg tcctggtagt ctgacaaagg caaaagtact gatcacagtt 53340 ttagatgtaa atgataatgc tccagaagtg actatgacgt ctttaagtag ctcaatccct 53400 gaagacacac ctcttgggac agtcattgct cttttctacc tacaagacag agattctgga 53460 aagaatggtg aggtgacctg caccattcca gaaaacctac cttttaaatt agaaaaatca 53520 atagataatt attatagatt ggtcacaacc aaaaacttgg accgggaaac actctctttg 53580 tataacatca cactgaaagc cacagatggt ggaactcctc ccttgtccag ggaaactcac 53640 atattcatgc aggtggcaga caccaacgat aacccaccca ccttccccca ctcatcctac 53700 tcagtctaca tcgctgagaa caaccccaga ggggcctcca ttttcttagt gactgcacag 53760 gaccacgaca gtgaggataa tgcccagatc acttattcct tggccgaaga caccatccag 53820 ggggctccag tgtcctccta tgtctccata aactctgaca ctggagtcct gtacgcgctg 53880 caatcctttg attatgagca gttgagagaa ctacaactaa gagtgactgc acatgacagc 53940 ggggacccgc ctctcagcag caacatgtca ctgagcctgt tcgtgctgga ccagaatgac 54000 aacccgcccg agatcctgta cccggccctc cccacagatg gttctactgg catggagctg 54060 gcaccccgct ccgcagagcc cggctacctg gtgaccaagg tggtggcggt ggacaaagat 54120 tcaggccaga acgcctggct gtcatacctc ctgcttaagg ccagcgagcc aggactcttt 54180 gcggttgggc tgtacacggg cgaggtgcgc acggctcggg ccctgctgga cagagatgcc 54240 ctcaagcaga gcctcgtggt ggccgtccag gaccacggtc agcctcctct gtcagccacc 54300 gtcacactca ccgtggctgt ggctgacagc atccccgaag tcttggccga cctgggcagc 54360 cttgagccct ccgacggtcc ttacaactat gacctcacgt tgtacctggt ggtggcggtg 54420 gccacagtct cctgcgtctt cctagccttc gtcctcgtac tgctggcgct caggctgcgg 54480 cgctggcaca agtcacgcct gctgcaggct tcagaaggtg gcttggcgaa cgtgcccacc 54540 tcgcactttg tgggcatgga cggggtgcag gctttcctgc agacctattc ccatgaggtc 54600 tccctcaccg cggactctcg gaagagtcac ctgatcttcc cccagcccaa ctatgtagac 54660 atgctcatca gccaggagag ctgtgagaaa aatgattctt tgctaacatc cgtagatttt 54720 caggaatgta aagaaaacct gccaagtatt caggtgagcc cagcccttcc tttatttcca 54780 tgaggaattt atttgcatga tatttctcta ttattttgca aaacaaatgt tttgaaaata 54840 gggatttaaa aaactttata gaggtaaaaa tgagtttacc agtttccttc agtggtgaca 54900 ctttaatata gaacacatag gatatagtat ttctttagtg aaagcctatg gacaagatta 54960 tgaatatgtg gactatcaca ttttataatt tccacctact ttccaatcta tgttccaacc 55020 tactttctta actcatatat tttatacatt ggaatgaatc gagtctttca tattgcacaa 55080 ggttagcagg aataaaacac acctcagctg tcttctcagg attctcttta gcattcaaat 55140 atgtaaaagg ttctgaaaga tttcttccat gtgaagattt ttttctgtgg ctgattctgc 55200 ctccatgtac ctcagcttgg tggtcctaaa aaatcttgat tgcttcttga cctatttaca 55260 gtataatcat ttattaatgg ggtggtagta gaaggttgga tttatgccta aagaatgaaa 55320 tgtgtgtgta tcacacttca ctaagatcta tatcaaagac agacatcaag tctaatgcca 55380 cactaaaggc catcggacaa aaccaataaa atatgtcaaa taaaatgtca ttttaagtgt 55440 tgtaattggc atttgtgaca taggcaatta catgttttaa cagagaattc cagtatgttg 55500 ttttagtggt acagccagat gaagtgtgtc tgtgggctat caaagtggga gattggggat 55560 actggctttg tttcaactgt ctcacgtact caaaccttag accatcttat gtacacagat 55620 cctagaccag tagttgattt tatttattag gtctactgaa aaattcagtt ggaaataacc 55680 caatctggga ttaactactt ccatattctt ttgtataaca ttttagtaaa gctcagtata 55740 tcaagtgatt gtcatccaga aggggtggat gacaaggtaa tcttgattcc agagaccttt 55800 gagtattaat taaaaacaca cttttagcca ggtatggtgt tgcaagctgt agcccacctg 55860 catgggaggc tgaggcaaga ggacagcttg aacccaagaa ttggaggccc acctagataa 55920 tataacaaga ctctgtctct tcaaaaaaag actcttttta gactagtgtt gtatttggta 55980 gtattttgca catgatagac tctgtacaat agtgtggggg atacattttt tttttttgac 56040 atggagtctc gctctgtcac ccaggctgga tacattttac aagttctgca gtgttcacat 56100 ttcagatgta caatcacttg gggtagaaga caatgttgct gacaccaaca atgttactga 56160 gggaagatcc tatggcagaa ctacggttat aaggtatttt gtaaaagaaa atctcctgac 56220 caaaatttat tagatgcata aaattgtttt taagcaatgg agagacataa tcactaaact 56280 cagtgagcta ttgcaatcaa actttccagg gattgtttcc ttcaattcag aggtcaccaa 56340 ggaatgtaaa ataagtgcag aggtaggaag cagtgcttca gtgcagcaga tctcagtgac 56400 tttgtgtttt gaggctatgt attatccccc tgataacttt gaagatgaat gttgtatttc 56460 ataaccagta aaataattgt gtaatgagga gaggagtagg ctactgcctg tgatcatcga 56520 aatgagaatc acataatatt cctgtaatga aatcactgaa actattggga agggggtgta 56580 tttgaagata agtataaatt gcaccttcta aaaggcaatt ttggtattac tgatactctc 56640 cggaaaaagt tgaaataaat caacttggag gtacttagaa aagtggagaa aatgttagga 56700 acaatgaaag aaagataaaa tgtatccagt atatttctaa tgagtaagta tggaaaatta 56760 ctgtactctg agacggttta ggccaagtct gtgttatggc tatctttata tagatagtgc 56820 atgtttgaag attggggaaa gcttatgtca ataaatgttt atgtacttaa tctacatgat 56880 ttgcctaaaa atcctcaaag ttgggatgaa ggcattccta agagtacatt tttagacgtc 56940 attaaatata cagacgtatc cacgtagttt ttgttctttc agttaggcac acaattataa 57000 ttattgcact ggttaacttg aagcagcaga ggctgtagtt tcctagtgct gactctgggc 57060 gccgctgttg gccaaagtgg agagcttggc gctccagatc tcctcgcgca gccgcagcgc 57120 gctttccagg gcagccccag ctcagactcc ccagcgccag cctttacacc gcttcctcct 57180 cggaaaaaga agaatttttt cttgaactgg aactgcaact aaagtccgtt cggagatcca 57240 aaaatctgca atacagaggt tatttgtaac ccggcgtctc caggctggtg agcaagctga 57300 ggagagcaag agggatgggg agcggcgccg gggagctggg ccgggctgag aggctgccag 57360 tgctctttct cttcctgctg tctttgttct gcccggcgct ctgtgagcag atccgctaca 57420 ggattcccga ggaaatgccc aagggctccg tagtggggaa cctcgccacg gacctggggt 57480 tcagcgtcca ggagttaccg actcgaaaac tgcgcgtcag ttcggagaag ccttacttca 57540 ccgtgagcgc agagagcggg gagttgcttg tgagcagcag gctagacagg gaggagatat 57600 gcgggaagaa gccagcttgt gctctggaat ttgaggctgt tgctgaaaat ccactgaact 57660 tttatcacgt gaatgtggag atcgaggaca ttaatgacca cacgccaaaa ttcacgcaaa 57720 attcctttga gctgcaaata agtgagtctg cacagcctgg cacacgattt atattaggat 57780 ctgcccatga tgcggatatt ggtagcaaca cactgcagaa ttaccaactc agtcccagtg 57840 atcatttctc actgataaat aaagagaaat cagatggcag taaataccct gagatggtat 57900 tgaagacacc tttggacaga gaaaagcaga aatcctacca cttgactttg actgccttgg 57960 actttggagc tccaccccta agcagcactg cacagataca cgttctagtg actgatgcca 58020 atgataatgc tccagtgttc agtcaagacg tatacagggt gagcctttca gaaaacgtgt 58080 acccggggac cacggtgcta caggtgactg ccacggacca ggatgagggt gtcaatgccg 58140 agattacttt ctctttcagt gaagctagcc agatcaccca atttgacctg aactctaaca 58200 ccggggaaat tactgtttta aatacattag attttgaaga agtcaaagaa tattccatag 58260 ttttggaagc aagggacggt ggaggaatga ttgcgcaatg cacagtggag gtagaagtca 58320 tagatgaaaa tgacaacgcc ccagaagtga tattccagtc tctacccaac ctaattatgg 58380 aggacgccga gctgggaaca catattgctt tgctcaaagt ccgtgacaag gattccagac 58440 acaatggaga agtgacttgt aaattggaag gtgatgttcc atttaaaata ttaacttctt 58500 caagaaacac gtataaatta gtgacagatg ctgttctaga ccgcgagcag aatccagagt 58560 acaatataac cgttacggca acagatcggg gcaagcctcc cctctcctcc agttccagca 58620 tcaccctgca cattggtgat gtaaatgaca acgctccggt tttctcacag tcttcctata 58680 tagtccacgt ggccgagaac aacccgcctg gagcctctat ttcacaagtc agggcttctg 58740 atccggactt ggggcccaac ggccaagtct cttactgcat catggccagt gacctggagc 58800 agcgggagct gtcatcctac gtgtccataa gcgcggagag cggggtggtg ttcgcgcagc 58860 gcgccttcga ccacgagcag ctgcgcgcct tcgaactcac actgcaggcc cgcgaccagg 58920 gctcgccagc gctcagcgcg aacgtgagcc tgcgcgtgtt agtggacgac cgcaacgaca 58980 atgcgccacg ggtgctgtac cccgcgctgg gtcccgacgg ctctgcgctc ttcgatatgg 59040 tgccgcacgc tgcagagcct ggctacttgg tgaccaaggt agtggcggtg gacgcagact 59100 caggacacaa cgcctggctg tcctaccacg tgctgcaggc tagcgagccc gggctcttca 59160 gcctggggct gcgcacgggc gaagtgcgca cagcgcgtgc cttaggcgac agggacgccg 59220 tccgccagcg ccttctggtc gccgtgcgtg acggtggaca gccaccactc tcggccactg 59280 ccacgttgca cctggtcttc gccgacagct tgcaggaggt gctgccggat atcactgacc 59340 gccccgaccc ctctgacctc caggctgagc tgcagtttta cctagtggtg gccttggcct 59400 tgatctcagt gctcttcctc gtggccatga ttctggccat tgccttgcgc ctgcgacgct 59460 cctccagccc cgcctcctgg agctgcttcc agcctggtct ctgtgttaaa tccgaatccg 59520 tggttccccc caactacagc gaggggactt tgccttattc ctacaatcta tgtgttgcac 59580 atacaggaaa gacggagttt aatttcctaa aatgtagtga gcagttgagt tcaggacaag 59640 acatactttg cggtgattca tctggggcct tatttccact ttgtaattcc agtgaattga 59700 cttcccatca ggtgagtttc ctttaagtat aatttaatgc tcattgccta cccatttctc 59760 catattcaca agaaaatata catatttgca ggaaaatata taatttttag atgtcatgga 59820 tcattttagg aaagttgtag tcagttaaaa agctgtcata tcattctaca aaggaggagt 59880 aaagtaggag caattgtgtg gcccaacatt tgtttgtttt ttagccaagc ttagatttat 59940 aaagcaatga gggtgtggtt ttaaccacaa agtgaaagtg ttagacagtt gttggctctc 60000 tcctaaaaag tgaatgagat ttttcctata cattttcctt cttgttgact aatatatgat 60060 gaatactttt ttcagcttgg atataccata aatataaaaa taataaagcc aaagaattta 60120 agctaaaatt caacactttt cttaactaat ttaactggta tggtctccat agtagtccac 60180 tgttttgttt cctgtgttaa cttccctttt gtttcaaaag ctcttagaat aaggagtcaa 60240 ctggattttt atgtccatgg accccttgtg attatatgca gtgtacgctg tgtgtgcgtg 60300 tgtgtgtgtg tgtgtgtgag agagatcctt ttacttagaa aaaggtctac tatgctcatt 60360 agaagatcaa aagcagattc tccttacttg taacatagga gtttcaggat taatctgtat 60420 tcaagctcat tctatatcct tcatcaaaga aaagacaatg ttttgtgtct gttgtccctc 60480 tcacacacag ccctaatata taatgtgtaa ctgccttatc tgcagcccta aactaatata 60540 gctagaggtc ttctaatcat tctcctacct ctaggaaaga aatatagtct tgaaaactgc 60600 caatctggtg tgcatacaaa atatatacaa aataccaagg aacattatat gagccttttg 60660 ctaggtatat ctaagcaact gcttcagtta atggccactt tacaaattgc tgaaagaagg 60720 aaacgtcttt cgattctttt ttttttcttt tttttttttt gagacagagt ctctgtctgt 60780 tactcaggct gtagtgcagt ggcacaatga tagctccctc cagcctcaaa ctcctgggct 60840 caagcattcc ttctgcatca gcctcctgac tagctggaac tcaggctcat gccaccagac 60900 ctggctaatt tttctgtttt cagtagagaa aatattttct ttcactaatt taactggtat 60960 ggtttccatt gtctacccag ttttccatat gcataagaaa atatattcac aggaaaatat 61020 aaagttttca gatttcatga gtggttttaa gaaagtttta gtcagtgaaa aaactatcat 61080 accagtcttc aaaggaaggg tgaaataagt tcatctgcta cgttgcccag gctggtcttg 61140 aagggaaaca gacttttttg tagtcatact tatcctttgg cttcttagta agtattatat 61200 agtcattact ttttgcagtt ttttagatca aagtgttaat gtaggtaaag ttaattttag 61260 aatatatgta aaagtcaagt ctgctttaaa tttaatcatc tctttggtga aagggatggg 61320 atggagcttt gctttttatc atatattcat ctgtaccttt caagtattca aatagaaaaa 61380 tataaacaat gtaaataaaa tagcaaaaca atgtaatatc tcataaaact gcaatggtaa 61440 aagcatttat cctattgaaa ttccacaatt tttatttgaa aatattatcg acatgtaatt 61500 caagtggcat ttagaagaat aatttaaaag caacaactct atagaaagct tgtaaaatga 61560 ttaagtagtt taaaccaaat aaaacaattt ctgagtcagt catctccagt aggtctattt 61620 tagtctcaag ataaattcat ttctggtgac aactgaagtt cttagttatt tgttagtata 61680 tattggagac atttacaata aagcttagag cacaatggga aatgaaagta tcatgttttt 61740 tttaagacca aatgtattgc agaaatgtga gtaatttaat ccgatgctac aatctgatca 61800 ttctgatcta atctgatcat ttaataacac taaataaaac cttcatctca cattctttgg 61860 ctgtttcttt taaaatatgg gtttacggat aaatcaaata aattcaaaac aaagtaataa 61920 gcaaatgatt tttttttctc agtaatctag tagagtatta catttagaag taatctgtat 61980 ctcagtgcag taactattta ggactgtaag cgccgctgtt cacctactgg aagacaaatg 62040 caaccgaaaa cactcagatc tcacacctca cgaagacccg cagatgccac aaactaactg 62100 ctggactgca gcgaaacccg acccctgttt ggaggcactc caggtttccg gaggattgtc 62160 atctccatag ctgcggcaag aaactaaata agacccattt atgcacagtg aagattctga 62220 gaggattctg cagcaaaaca acaatggccg ctccacagag tcgccccaga cgcggcgagc 62280 tgatcctgct gtgcgcgctg ctgggaacgc tgtgggaaat cgggagggga cagattcgct 62340 actctgtgcc agaagagacg gacaaaggct ccttcgtggg taatatctcc aaggacctgg 62400 ggctggaccc ccggaagctg gcgaagcacg gagtccgtat cgtctccaga ggtaggacgc 62460 agctctttgc tctgaacccg cgcagcggca gcttgatcac cgcgggcagg atagatcggg 62520 aggagctctg cgctcagagc ccgcggtgtc tgataaatat taacaccctg gttgaggata 62580 aaggaaaact ctttggggta gaaatagaaa taattgatat taacgataat aacccaaaat 62640 tccaggtcga agatctagaa gtaaaaatta acgaaatcgc ggttcctgga gcacgttatc 62700 cactcccaga agctgttgac ccggatgtgg gcgtgaactc cctccagagc taccagctca 62760 gccccaatca ccacttctcc ctggacgtgc agactggaga caatggagcc ataaacccag 62820 agctggtgct ggagcgcgcc ctggacaggg aggaagaggc tgctcaccac ctggtcctca 62880 cggcctcgga tggcggcaag ccgcctcgct ctagcacagt gcgcatccac gtgacagtgt 62940 tggatacaaa tgacaatgcc ccggtttttc ctcacccgat ttaccgagtg aaagtccttg 63000 agaacatgcc cccaggcacg cggctgctta ctgtaacagc cagcgacccg gatgagggaa 63060 tcaacggaaa agtggcatac aaattccgga aaattaatga aaaacaaact ccgttattcc 63120 agcttaatga aaatactggg gaaatatcaa tagcaaaaag tctagattat gaagaatgtt 63180 cattttatga aatggaaata caagccgaag atgtgggggc acttctgggg aggaccaaat 63240 tgctcatttc ggtggaagat gtaaatgaca atagaccaga agtgatcatt acgtctttgt 63300 ttagcccagt gttagaaaat tctcttcccg ggacagtaat tgccttcttg agtgtgcatg 63360 accaagactc tggaaagaat ggtcaagttg tctgttacac acgtgataat ttacctttta 63420 aattagaaaa gtcaataggt aattattata gattagtgac aaggaaatat ttggaccgag 63480 aaaatgtctc tatctacaat atcacagtga tggcctcaga tctaggaaca ccacctctgt 63540 ccactgaaac tcaaatcgct ctgcacgtgg cagacattaa cgacaaccct cctactttcc 63600 ctcatgcctc ctactcagcg tatatcctag agaacaacct gagaggagcc tccatctttt 63660 ccttgactgc acacgacccc gacagccagg agaatgccca ggtcacttac tctgtgaccg 63720 aggacacgct gcagggggcg cccctgtcct cgtatatctc catcaactct gacaccggtg 63780 tcctgtatgc gctgcaatct ttcgactatg agcagatccg agacctgcag ctactggtaa 63840 cagccagcga cagcggggac ccgcccctca gcagcaacat gtcactgagc ctgttcgtgc 63900 tggaccagaa tgacaacgcg cccgagatcc tgtaccccgc cctccccaca gacggttcca 63960 ctggcgtgga gctggcgccc cgctccgcag agcgtggcta cctggtgacc aaggtggtgg 64020 cggtggacag agactcgggc cagaacgcct ggctgtccta ccgcctgctc aaggccagcg 64080 agccgggact cttctcggtg ggtctgcaca cgggcgaggt gcgcacggcg cgagccctgc 64140 tggacagaga tgcgctcaag cagagcctcg tggtggccgt ccaggaccat ggccagcccc 64200 ctctctccgc cactgtcacg ctcaccgtag ccgtggctga cagcatcccc gaagtcctga 64260 ccgagttggg cagtctgaag ccttcggtcg acccgaacga ttcgagcctt acactctatc 64320 tcgtggtggc agtggctgcc atctcctgtg tcttcctcgc ctttgtcgct gtgcttctgg 64380 ggctcaggct gaggcgctgg cacaagtcac gcctgctcca ggattccggt ggcagattgg 64440 taggcgtgcc tgcctcacat tttgtgggtg ttgaggaggt acaggctttc ctgcagacct 64500 attcccagga agtctccctc accgccgact cgcggaagag tcacctgatc tttccccagc 64560 ccaactacgc agacatgctc atcagtcagg agggctgtga gaaaaatgat tctttgttaa 64620 catccgtaga ttttcatgaa tataagaatg aagctgatca tggtcaggtg agtttagttc 64680 tttgcttgct tttaatttcc agatgaattt tatttggcat aaattatgtt ttgaaaaaca 64740 ttgtgaagat agttgaaaat aatttttaag gtgtatcaca gagttttggg tttattttgg 64800 tggtgttact ataaaattga actctaatag tcataggtta ttgtttcatt tgcttttaaa 64860 cgacttggaa aagattgttc aaccatttta agccttccag tattttattc ctattatcac 64920 tcattcactt aagaagtagc tacccgtcca tactggtaat tttgctattg tttgtgtgtg 64980 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tatcccaaac tagaacttca 65040 gaaaattatc aagaagtcta aagccttgtt attagcttag caaaagtaaa atatatctca 65100 gaatttttag ggttatgttt agcatttgaa cctgtaacta ggctcttgta gatttcttca 65160 ctttaaacct cttttctgag ccctgtttct gtaccagtgc ccttcaaaac tttaatactt 65220 cttaccatcc ttcaaaacat gaacaaactt taaagatgga tcttggtggg agatgagact 65280 ggttactaaa tattaagtat gtgagtcagt ggtcacctgg gctccatgcc catggagaca 65340 tgaaatctaa agcctagaat gtccattgct cccccaaaca aaaaacaaaa gcaaaaacat 65400 tagatctgaa ttaaaatgta attttaaact gttgaaagtg acttttgtaa aatatgtaag 65460 aacatatttc aatacaattc caattagctg tttcggttgt gcattgatgt gaagtggtga 65520 gaatgttgat attaagaacc aatgtttcag gtacacaagt tctaaataag ctgatcaatt 65580 caattaaagt tattcagtct tggctggaca cagtgcctca tgtctgaaat cccagcactt 65640 tgggaggctg gggcaggagg accgcttgag ccccgggggt ttgaaactgc agtgagctat 65700 gatcatgcca ctgcactcca gcctaggtgg cagaactaga ccctgtctct aaaaaaacta 65760 ttattaggcc gggtgcggtg gctcacgcct gtaatcccag cactttggga gactgaggtg 65820 ggtggatcac ctgaggtcag gagttcaaga tcagcctggc aaacatggtg aaaccccgtc 65880 tctactaaaa actacaaaaa ttagccaggc atggtggcat gcgcctgtgg tcccagctac 65940 tcgggaggct gaggcagaag aatcacttga acccgggagg tggaggttgc agtgagcctc 66000 gatcctgtca ctgcactcca gcctgggcaa cagggtgaga ctccgtctca aaaaaaaaaa 66060 aaactaatat taatagtaaa aactcggtat aggctatcca ttattgtatt cctgcatacc 66120 ttcttgtagc atttgaataa agctaatacc tgaattgatt gttgtaaggt agaagtagat 66180 gacccaataa atgtttgtta ttaatgaaaa ggacatttcc taaggattgt gtagtgttct 66240 actgtatggt gcatattcag tggagtggga gttaacttca tagtttgtgt accatttgga 66300 tgcacatttg agaggacaac atattattgg cactttgcaa ttttaaaaac tcggatgaaa 66360 gttgccctgg taggaaagaa aatccttact ctccctaaaa atgttggcta gttgttttta 66420 ttaatctgac aaatggacta aagaaggttg accaatgtcc acaaatttat gtaaatgaac 66480 ttatgagctt catttatcca attccaaagt catttcagat aggataataa tgcaatccac 66540 tagaatatcc ctttgtacct tgtattgcag aatagataag catttcccca ataactctta 66600 agaatgaatt tatgtactgt aaaagatatg acataagaga agtattttga gatatgaaga 66660 agagcaacgt agtagggtat atcatttctt agctacatca tatgggcagt atacttgaat 66720 gaatatttcc tgaagtagaa gagtaaagaa aaattatttt tataaagaat gttaatatag 66780 tcaggaagag gagatgtttg gggattggta taaaattgcc acaactttac aaaatagttt 66840 taaatagtat agatttccct aatatgtgta atataaaaca ctagaaatat tggggagttg 66900 gaaatcatag aaatgaacag aagaatgata aaattgtttc catagctaat aaaaaatgaa 66960 tttttgaaat cagtatagta tgaaggctct gagagcaaga actgtatcat attaattatt 67020 atattgccag tgacaagggc aatacttagt tctagctaag agttcaaggt atgtttgcag 67080 aatggtgaaa gaatggacca atgtatgcag gtttgtataa aaacccaacg tgatatttct 67140 aacaatttgg aaaacagaga aagatacctt aaagaagttg ttataatttt ttattaagta 67200 tatggacgta aaaacttggc ttgttaagtt aggcacacaa aaacaattac tgcactggtt 67260 aacttgaagc cgcagaggct gtagtttcct agtgctgact ctgggcgccg ctgttggcca 67320 aagtgcagag cttggcgctc cagatctcct cgcgcagccg cagcgcgctt tccagggcag 67380 ccccagctca gactccccag cgccggcctt tacaccgctt cctcctcgga aaaagaatcg 67440 tttcctaaac tggaactgga actaaagccc gttcggagat ccaaaaatct acaatacaga 67500 ggttatttgt aacctggcgt ctccaggctg gtgagcaagc tgaggagagc aagagggatg 67560 gggagcggcg ccggggagct gggccgggct gagaggctgc cagtgctctt tctcttcctg 67620 ctgtctttgt tctgcccggc gctctgtgag cagatccgct acaggattcc cgaggaaatg 67680 cccaagggct ccgtagtggg gaacctcgcc acggacctgg ggttcagcgt ccaggagtta 67740 ccgactcgaa aactgcgcgt cagttcggag aagccttact tcaccgtgag cgcagagagc 67800 ggggagttgc ttgtgagcag caggctagac agggaggaga tatgcgggaa gaagccagct 67860 tgtgctctgg aatttgaggc tgttgctgaa aatccactga acttttatca cgtgaatgtg 67920 gagatcgagg acattaatga ccacacgcca aaattcacgc aaaattcctt tgagctgcaa 67980 ataagtgagt ctgcacagcc tggcacaaga tttatactag aagtagcaga agatgcagat 68040 attggcttaa actctctgca gaagtataaa ctctctctta acccaagttt ctcattaata 68100 attaaggaga aacaggatgg tagtaaatac ccggaactgg cactggagaa aaccttagac 68160 cgggaacaac agagttacca tcgtttagtc ctgactgcct tggacggtgg acatccaccc 68220 ctaagcggca ccactgagct ccggatccag gtaaccgacg ccaatgataa tcccccggta 68280 ttcaaccgag acgtgtacag agtcagcctt cgggaaaacg tgccaccagg caccactgtg 68340 ttgcaagtgt cagccactga ccaagacgag ggcatcaact cagaaattac ttattccttc 68400 tacagaaccg ggcaaatctt tagtctgaat tcaaagagcg gagaaattac cactcaaaag 68460 aaactggatt ttgaagagac caaggaatat tcaatggttg tagaagggag ggatggtggt 68520 ggactggttg cacaatgtac agttgaaatt aatattcaag atgaaaatga caatagccca 68580 gaagttacat tccattctct acttgaaatg attctggaaa acgcggtgcc tggaacacta 68640 attgctttga tcaaaataca tgaccaagat tctggggaaa atggggaggt taattgtcaa 68700 ttacaaggcg aagtcccttt taagattatc tcttcatcca aaaattcgta taagttggta 68760 acagatggaa ccctagaccg agagcaaacc ccggagtaca atgtcaccat cacagccaca 68820 gacaggggca agccgcccct ctcctccagc ataagcgtca tcctacatat cagagacgtc 68880 aacgataacg ctccggtttt ccaccaggcg tcctacttag tcagtgtacc cgaaaacaac 68940 cctcctgggg cctccatcgc gcaagtctgc gcctcggacc tggacttggg gttgaacggc 69000 caagtctcct actctatcat ggccagcgac ctagagcctc tggcactggc ctcttacgtg 69060 tccatgagcg cgcaaagtgg ggtggtgttc gcgcagcgcg cctttgacta cgagcagctg 69120 cgcaccttcg aactcacact acaggcccgc gaccagggct cgcctgcgct cagcgcaaac 69180 gtgagcctgc gcgtgttggt gggcgaccga aacgacaacg caccgcgggt gctgtacccc 69240 gcgctgggtc ccgacggctc tgcgctcttc gatatggtgc cgcgcgctgc agagcccggc 69300 tacctggtga ccaaggtagt ggccgtggac gcagactcag gacacaacgc ctggctgtcc 69360 taccacgtgc tgcaggctag cgagcccggg ctcttcagcc tggggctgcg cacaggagag 69420 gtgcgcacag cgcgtgcctt gggcgacagg gacgcggccc gccagcgcct gctggttgct 69480 gtgcgtgatg gtggacagcc gccactctcc gccaccgcca cgctgcactt ggtctttgct 69540 gacagcttgc aggaggtgct gccggatatc actgaccgcc ctgtaccctc tgacccccag 69600 gctgagctgc agttttacct agtggtggcc ttggccttga tctcagtgct cttcctcctg 69660 gccgtgattc tggccgttgc cttgcgcctg cgacgctcct ccagccctgc cgcctggagc 69720 tgcttccaac ctggtctctg tgtcaagtct ggacctgtgg ttccccccaa ctacagtcag 69780 gggactttgc cttattccta caacctatgt gttgcacata caggaaagac ggagtttaat 69840 ttcctaaaat gtagtgagca attgagttca ggacaagaca tactttgtgg tgattcatct 69900 ggggccttat ttccactttg taattccagc gagtcgactt cccatcctga gttggtgagt 69960 ttcatttatg tctattcttt ttcattaccc acccaatttt ctgtatttac atgaaactat 70020 cgtacatttt caagtccaat gagttgtctt agggaagtca gagctgctca gaaagctgtc 70080 ctaccattct ttaagaggag cagtaaattg tgagttttta tgtcgcataa aagaagtagc 70140 cttatagatt tacaaagtag tgagagtttg ctcttagctt cctctctagc aaaaacattt 70200 ggtgcgtttt tttgtcctct ttctcaaagc taatgaattt tacctattcg ttgtctcatt 70260 ctttaacatg tttatatttt attgtatgta gataaaccat taaatttaat gtatgtaatc 70320 atttaattca tcttttaaag caaagaaact gctagtagat gtctttcttc actgatttca 70380 ctggtagttt tcatctcttt cttatgttcc tcatatatgc tttcttattc ctacctaatg 70440 gatttatgat tttttgaatc tcctaaaatt ttattaaaaa tactatatgt tggctgggtg 70500 cagtggctca tgcctgtaat cccagcactt tgggaggccg aggcggttgg atcacatggt 70560 caggagttca agaccagcct gggcaatatg gtgaaaaccc gtctctacta aaaatacaaa 70620 aattagctgg gtgtggtggc gggcgcctgt aatcccagct actcaggagg ctaagacagg 70680 agaattgctt gaacctggca ggtggaggtt gcggtgagcc gagatcactc cattgcattc 70740 cagcctgggc aacaagagca aaactccatc tcaaaaaaaa ggaaggagaa ggagaggaag 70800 aagaagaaaa atactacatg ttatgtgtat gagagagaaa gagagagact gattcactga 70860 acttagaagg tccaaatcat ccaaataatt ttctaagttt atccaggttt tcttggatgc 70920 aaaatccttt tccacctcta tataattacc agaagaaact tacaaaaaaa aggaaatgct 70980 attgcctgaa tttctcttgc tcggaatcct gacatattct tgaagaaggg gaaaaagaca 71040 ccggatttgt cttatcgttt ggagctttaa atataaatga ctggatgttt tctcaacatc 71100 cttgtaggat ggaaggtgaa tacaggatta ttccattttt aagacaaaaa ctactagtct 71160 tgtgtacata caaagctccc attacatggt ataagtcttt tgcttggttt cccttagtat 71220 gtgattcagt aaatgggttc cttacaaagt gctgagattt cttataatac cacttacttt 71280 taacctttca gtagttttct ttgttgtata ttttgtgttc tttttcccaa attattatat 71340 aagtttaagt gatgcttaga ataatgttta agaccacttt aaaattgcat aatttattga 71400 tgaaggatta aaatagaaac ttgcttttca gtgtatatgc atttgaatca ttgaaacaca 71460 gtctgtgcat gcattacata ttcacattaa aaaactaagc atttttgaaa tagcagaaaa 71520 gtttaagcaa ttacaaaaat gtgaaaattt ccaactttaa tcctgttaat atttagcaat 71580 attaggcgag aacatctgta actattgctg aattaatatt acttttataa tacaaaaatt 71640 taaaataaac gtttttccag gaattttatc atcaaaataa accccagaaa ataatttcaa 71700 agtggataat ctatccttat atatgtatta atacaattat atattttaca tttacaaata 71760 tataggtata aaaattaaaa atgaatgtac ttccaaacaa gattgcacat aaaaattact 71820 tcagaaaatt gttaagatac acagaaaaaa ttgaagcatc ataaaaagga aattataata 71880 gtttacatat ctagaaatag agtgcaaagt tctaccaaga ataagaataa attaatatta 71940 agcaatggtt tgtgatttta taatacactt acagaaattt tattccactt tatttacaac 72000 tcagatatct aaaaaataga ttgcttttga aatacaaatg caagaaacaa ttggagaaat 72060 ctaaaatcat aattagaaga gagtagtgtt ttctttatca gccatctgat ataatgttac 72120 acatcagtgg gtgtagtaac ggcttaggac tctgagcgcc gctgttgatc aactctaagc 72180 gaaaatcagg actccatccg gatttccagt tctgcggcta cacaaaaccc ggcagatacc 72240 acaaacctgc tcccaggctg cagcaaaact cagcctcttt cttctaagga aaagatcacc 72300 atactttgca gggtggaaga aagaacctga tgaagcagcg cgcacagaga tccttttgag 72360 aaaattccaa agcgaggcag caatggcagc tccaaccaaa tgccagctcc gcggaagatt 72420 agtcctgcta tgctcgctcc tggggatgct atgggaggcc agggccagtc agattcgcta 72480 ctcagtgcct gaagagacag aaaagggcta tattgtgggc aacatctcca aggacctggc 72540 tctggagccc cgggagctgg cggagcgccg agtccgcatc gtctctagag gtaggacgca 72600 gcttttctct ctgaacccgc gcagcggcac cttggtcacc gcgggtagga tagaccggga 72660 ggagctctgt gctcagagcc cgcggtgtct ggtgaacttt aaagtcctgg ttgaagacag 72720 agtgaaactg tacggaatag aaatagaagt aactgatatt aacgacagcg ccccaaagtt 72780 ccaggccgaa agtctggaag taaaaattaa cgaaatcgcg gttcctggag cacgttatcc 72840 acttccagaa gctattgatc cggatgttgg cgtgaactcc ctccagagct accagctcag 72900 ccccaatcac cacttctccc tgaacgtgca gactggagac aatggagcca taaacccaga 72960 gctggtgctg gagcgcgccc tggacaggga ggaggcaact gcccaccacc tggtcctcac 73020 ggcctcggat ggcggcgagc cgcgtcgctc cagcacagtg cgcatccatg tgacagtgtt 73080 ggatacaaat gataatgccc cggtttttgc tcaacggatt taccgagtta aagtccttga 73140 gaacgtgccc ccaggcacct ggctgcttac tgcaacagcc agcgacctgg atgagggaat 73200 caacggaaaa gtggcataca aattctggaa aattaatgaa aaacaatctc tgctattcca 73260 gcttaatgaa aatactgggg aaatatcaac agcaaaaagt ctagattatg aagaatgttc 73320 attttatgaa atggaaatac aagctgaaga tggtggggga ttgaaagggt ggacaaaagt 73380 gctcatttcg gtggaagatg taaatgacaa tagacctgaa gtgaccatta catctctgtt 73440 tagcccagtg agagaagacg cacctcaggg aacagtaatt cttcttttca atgctcatga 73500 ccgagactcc gggaagaatg gtcaagttgt ctgttctatc caggagaatc tatcttttac 73560 attagaaaat tcagaagaag attattacag attgttgacg gcccaaattc ttgaccgaga 73620 aaaagcctca gaatataata tcacggtgac tgcaacagac agaggaactc cgcccctgtc 73680 cacagaaatt cacatcaccc tgcaagtgac tgacatcaat gataatccac ctgctttctc 73740 tcaagcctcc tactcagtct acctcccgga aaacaacgcc agaggtactt ccatcttctc 73800 cgtgattgcc tatgaccctg atagcaatga gaattctaga gttatttact ccttggcaga 73860 ggataccatc caagggtctc ctctctccac ctatgtctct attaactcag acactggtgt 73920 gctgtatgct ctgtgctcct ttgactatga gcagtttaga gatttgcaaa tgcaggtgac 73980 ggcaagtgac agtggaagcc caccacttag cagcaatgtg tcattgagac tgtttgtttt 74040 ggaccagaat gacaatgccc cagaaatcct gtaccctgcc ctccccactg atggttctac 74100 tggtgtggag ctggcacccc gctctgcaga gcctggctac ctggtgacca aggtggtggc 74160 agtggacaga gactcaggcc agaatgcttg gctctcctac cgcctattca aggccagtga 74220 gccagggctc ttctcggtgg ggctgcacac aggtgaagtg cgcacagctc gggccctgct 74280 agatagagat gcgctcaaac agagccttgt ggtggctgta caggaccatg gccagccccc 74340 tctctcggcc actgtcacgc tcacagtagc catagctgac agcatcccag acatcctggc 74400 tgacctgggc agtcttcaga tccctgcaga cctggaggcc tcagacctta ccctctacct 74460 cgttgtggct gtggcagtcg tctcctgtgt cttcctcacc ttcgttatca cgctgctggc 74520 cctcaggctg aggcactggc actcctcgca tctgctgcgg gctaccagtg atgggttggc 74580 tggtgtgccc acctcacact ttgtgggtgt agatggggtt cgagctttcc tacagaccta 74640 ttctcaggag ttctccctca ccgctgactc aaggaagagt cacctgatct tcccccagcc 74700 caactatgca gacacactca tcagccagca gagctgtgag aaaaatgagc ctttgtgcgt 74760 ctctgttgat tccaagtttc ctatagaaga cacccctttg gttccggtga gttcattttt 74820 tttctttctt tcttttcttt ttttgttttt tgttttgttt tgtttttgag acagagtctt 74880 actctgttac ccaggctgga atgcagtggt gtgatctcgg ctcattgcaa cctccgcctc 74940 ccaaattcaa gcgattctcc tgcctcagcc tcccaagtag agtagctggg actagagtag 75000 agtagctggg actacaggcc tcccaagtag aataactggg actacaggca cgtgccacca 75060 cgcccggcta attttttgtg tgtttttagt agagacgggg tgtcaccatg ttggccaggc 75120 tggtcttgaa ttcctaacct caagtgatcc acccacctca gcctcccaaa gcactgggat 75180 tacaggcgtg agccactgcg cctggccctt aactttctat tatagttagc tttctcttta 75240 actgtctgta cttaaggtag tataagttga tatcagtgtg tttctcatca cttttcactg 75300 ggcctaattg ttgctccaac actgaaagga ggcatttatt agttatattt gctgatataa 75360 ctttcatgtt ctcataataa ttaacctgct gtcaacgtaa accatacttc atggggtagc 75420 tctcagcctg cattgatgtg ggctttttgg gtagggttgc ttcattggtt gcagtggact 75480 catatcataa aattcttact cctttttttt tttttttaag agatgggggt gtcattctgt 75540 tgtccagggt ggaatgcagt ggtgtgggta aagcttactg cagtctcaat ctcctgggct 75600 tatgcaatcc tcccacctca gccttcacag tagctaggac tgaggtggga gggctagcaa 75660 gctatgttgc ccagactggt ctcaaacgat cttcctgctt cagtttccca aagcactggg 75720 tgaggtgtga accacctcac ccagcaaatt cttactccta cgatcattta ttcaggtcat 75780 actatgtttg taagggtaaa ctgataaaaa ggtaaatgta ttcttcttag agaaacagct 75840 gaaagcccag atttattgct tctattcttc catttctatg acaggaaaac acctctttga 75900 ggttatattt ttcagatcac aagtgtgtaa agtctgtttg tgtttacaga tattttctga 75960 cgaagattca aacttcagtt atccacttcc aaaccctagt aaaccaattt tttcccttta 76020 atggtgaaag ttgtcacatc ttttattctc atatcttcaa aggtcttaat ttcctaatgc 76080 tttaatgtta aattatggag aatagtagga cattcttctt ttctatagta tatgcttgct 76140 caagagaagt ttctaagact ggacactgtg aaatgacaaa acaaggaatt aaaaatattt 76200 ctctcactta tatattattt ctggctcaat tctccaactt ttgagtctag aaatgaactt 76260 gcatatcaga tataatttaa gaaaatattc tcaggaactg ctgggaagat tctaaaacta 76320 ttttactgtt tttagctata aggaagagaa taatgtatta tttaatgtta ttttaaacat 76380 agtgttgttt caaatagtaa ataacatttc acaagacatt tgaaaataag ctttgaagtt 76440 gactcaaaat tctatgctaa acatgtgatc catagataca ctgatgactg ctggcatttc 76500 tgtggaaatg aagaattgtt ttatttgttt gtaattattt gggtttcagt tgctttattt 76560 ttaagaaaaa aaagctgaag tgtctgggaa tcctttatga catacagaca ttttaattat 76620 ttcaaacacg ttttccccct taagtgggta gcaaaaaaaa taaagcatac ttcaggctca 76680 tatttttaac catgcaacaa gaaaattgtt acaatttctg ttctgaggag tagccttcat 76740 acttagtatt tataaatatt gaaatgtatg ttaatttggg gaaaacataa cagatatcca 76800 tgaaggcttg tatgtcatgg taggtagtta ctattcgata ccacaaaaat gtctcttgcc 76860 cttaaaacca gaacacgagg ctcaccagac agatgactga atggagtatg gaaaatcttt 76920 atttctgttt ttcttaggct atgtaggact taacttattg tgcattggta acagattgta 76980 gaacataagc tgaaagataa aattcttgac cttaatgtct catcttaaaa agaagcattg 77040 gttgacattc tatatctcgt attacttaaa aataatgggg gagcgcagta tatattaaac 77100 aaagattggc tttgtggtga tcattgttga aggtggggtg atggctatgt gaaggttcac 77160 tatatatact ccctactgtt gtataagttt gaaattgtgc ataatagatt tatttaaaac 77220 acaaagcata gaaatatcta ctataatatt atggtgagag caaaatttga gggggatgta 77280 cacctgcatt ttcgaagaat atatacattt cggagaccga attcaaaatg aaaaaccggg 77340 ctgctgtccc gcacggagcc tctgggcgcc gctgtcggcc agtgcagagc aagcgctgac 77400 gccggggatc cgtcagcctc tggcctggga ttccctgcgc agccaacaac agaaagaaga 77460 aaaccagctc ccacacagag cctcccggct gcgcagacct ttcccagcac agcggattgc 77520 cagctccgag acccgggact cctcctgtcc tgggccgaat gctcttttag cgcggtagag 77580 tgcactttct ccaactggaa aagcggggac ccagcgagaa cccgagcgaa cgatgggagg 77640 gagctgcgcg cagaggcgcc gggccggccc gcggcaggtg ctatttcctt tgctgctgcc 77700 tttgttctac cccaccctga gtgagccgat ccgctactcg attccggagg agctggccaa 77760 gggctcggtg gtggggaacc tcgctaagga tctagggctc agtgtcctgg atgtgtcggc 77820 tcgcaagctg cgagtgagcg cggagaagct gcacttcagc gtagacgcgg agagcgggga 77880 cttacttgtg aagaaccgaa tagaccgtga gcaaatatgc aaagagagaa gaagatgtga 77940 gttgcaattg gaagctgtgg tggaaaatcc tttaaatatt tttcatgtca ttgtggtgat 78000 tgaggatgtt aatgaccacg cccctcaatt tgataaaaag gaaatacatt tagaaatttt 78060 cgaatctgca tccgctggta cacgactatc gcttgaccct gccacggatc ctgatataaa 78120 cataaactca attaaagatt ataagataaa ctctaatcct tatttttcat taatggttag 78180 agttaattcc gatggtggca aatacccaga gttatctctg gagaaactcc tagaccggga 78240 agaacagaga tctcatagct tgatattgac tgccttggac ggaggggacc caccaagaag 78300 tgccaccgct cacatagaaa tttctgtcaa ggataccaat gataaccccc cggttttcag 78360 cagagacgaa tatagaatta gtcttagtga aaatctgccc cctgggtccc ctgtgttgca 78420 agtgacagcc actgaccagg atgagggggt caatgctgag ataaactact acttccgaag 78480 cactgcccag agcacaaaac atatgttctc attggatgag aaaacaggta tgattaagaa 78540 taaccagtca tttgattttg aagatgtaga aaggtacacc atggaagtgg aagcgaagga 78600 cggaggtggt ctctctaccc agtgtaaagt aatcatagaa atccttgatg aaaacgacaa 78660 cagcccagaa ataatcatca cttctctctc tgatcagatt ttggagaatt cacctccagg 78720 aatggttgtt gccctcttca aaacacggga tctggatttc ggaggaaatg gagaagtcag 78780 gtgtaatata gaaacagaca ttccattcaa gatttattct tcttccaata actactacaa 78840 actggtgaca gatggagccc tggaccgaga gcagacacca gaatacaatg tcaccatcgt 78900 agccactgac aggggcaagc cgcctctttc ttccagtaga agcatcacct tgtatgtcgc 78960 tgacatcaac gacaacgccc cagttttcga ccagacgtcc tacgtggtcc acgtggccga 79020 gaacaacccg ccaggagcct ccattgcgca agtgagcgcc tctgacccgg atttggggct 79080 caatggccac atctcctact ctatagtggc gagtgaccta gagcccctgg cggtgtcgtc 79140 atacgtgtca gtgagcgcgc agagcggggt ggtgttcgcg cagcgcgcct ttgatcacga 79200 gcagctgcgc gccttcgcgc tcacgctgca ggcccgcgac cacggctcgc ccacgctcag 79260 cgccaacgtg agcctgcgcg tgttggtggg agaccgcaat gacaacgcac cgcgggtgct 79320 gtacccagct ctgggtcctg acggctccgc gttcttcgat atggtacctc gctctgcaga 79380 gcccggctac ctagtgacta aggtggtagc ggtggacgcc gactcgggac acaacgcctg 79440 gctgtcctac cacgtgctgc aggccagtga gcccggactc ttcagcctgg ggctgcgcac 79500 tggggaggtg cgcacggctc gagccttagg cgacagggac gcagcccgcc agcgcctgct 79560 ggtcgctgtg cgtgacggtg gacagccgcc actctctgcc accgccacgc ttcatctggt 79620 cttcgcagac aacttgcaag agatactgcc agacctcagc gaccgccctg tactctctga 79680 cccccaggct gaactgcagt tttacctggt ggtggccttg gccttaatct cagtgctctt 79740 cctcctcgcc gtgattctgg ccattgcctt gcgcctgcga cgctctctca gccctgctac 79800 ttgggactgc ttccatcctg gtctctgtgt caagtctgga cctgtagttc cccccaacta 79860 cagtgagggg actttgcctt attcttataa tctgtgcatt gcacatacgg gtacaaaaga 79920 gtttaatttc ctaaaatgca gtgtgcccct acattccaat gaagacatgg tttgcagtgt 79980 ttctcctgga gccttaattc cacctcatgg tggggaggat ttgacttcac atcctgagac 80040 tctgacttcg gtgagtttct cttttttgtg tgtgatttat ctaatagtct actagtttct 80100 catattttag gcatactact ttattttcat atctagaatc atatgtttaa aatccatagc 80160 tttttacaat attttctcaa tgttttttca attatagttt tcactatgta tttggttcat 80220 aagttgctct atctttttgt aaaataatgt caccagactg aagatatttt gtctttgtct 80280 tttttttttt tttttttttt tgagatggag tctcgcactg ttgcctaggc tggagtgcag 80340 tggcgtgatc tctgctcact gcaacctccg ccttctgggt tcaagcgatt ctcctgcctc 80400 agcctcccaa gtagctggga ttactggtgc ccctcaccac agctaaattt tttgtatttt 80460 tagtagacat ggggtttcac tatgtcgacc aggctgttca gaaactcctg tcctcgtgat 80520 cctcccacct tggcctctca aagtgctggg attacaggcg tgagccacaa tattttgtca 80580 agttctgact atcgaacaga agcagtggtc ttggcatcta agaaaacaaa caagtaacct 80640 atctattcaa atttgcgaag acttagtgaa tttacgatat cttatttata tatttttaaa 80700 gcctaaaaat attcagaaga caggcccagt ggctcacacc tataatcaca gcactttgat 80760 aggctgaatc ggaaagtatc acttgagccc aagaattgag accagcctgg gcaatatagg 80820 gagacccccc atctctacta aaacaacaac aacaaaaaaa aacattagca gagtgtggta 80880 gcattcccct gtggtcccag ctacttggga ggctgagctg ggtggattgc ttggtcctgg 80940 gaggtcaagg ttgcagtgag ccctgatctt gccactgcac tccagcctgg gcgacagagt 81000 gcgaccctgt ctctaaaata aataaataaa tatgcaggca gggccaagtg tgctgtaatc 81060 ccagcacttt gggaggtgga ggtggagaat ctcttgagcg caggaatttg agaccagcct 81120 gggcaacaca gggagactcc atcgctacag aacatttaaa aattagcagg gtgtggtggc 81180 acatgcctgt ggtctcagct actctggtgg ctgtggtggg agaatcgctt gagcccagga 81240 agtctaggct gcagtgagct gtctaggtga cagagtgaga ccctgtctca aaaaaaaaag 81300 acatttctaa gaaataaatg aaatactatt gcctttgcac tcagtctctg tctctgattc 81360 tctgatagaa gatttttgaa gaaaaaagat aaaatctttg aagagttcta tacttggaag 81420 gcatagtgac ataaacactt ctgaacatcc tgttctctgt gtgaaagaag tgaacttcta 81480 taccctttgc atttgaggga acaattgcta ctgggttgat gggcacacac agttgaagat 81540 atgtgaacca ctggactttg gcctctgata caaactgcct aagagaagag attatttata 81600 ctggtattaa tgctctgatg aaaacaggtc atttgacata aacacttact tgttaaaaac 81660 ctatatcact acatctaact ttgttttcta aaacttttag tacttcaaat tctacgtatt 81720 tcttttctca ttacaatgca aacagtttaa tttgcaactg taatatatgt tcattttagt 81780 ttgtgattac ctgcttaatc atttaaatag gtccatttaa cttgtatccc tgtaagataa 81840 agtatgtttt acacaaaaag gttaattaag gctcagtaaa actattctag aagagtactt 81900 taaaaacctc ttacacaatc ctaagctaaa taagtttaat gaattaagta gttacaatta 81960 taaagcttca gagtgaatta tctcatgagt ttatttaata taatctttgt atgaatgtat 82020 actaaataaa attggcctat tcaaatcaca attttaaatt ataagacttt tctgaattta 82080 cctagacact aatatgacct aaaataagta ttatttacct tttattaaag tgtgtacatt 82140 tctgttggga aaacgtgttg caaatatata tttaaccaaa cattatcttg aaatatttac 82200 aatattttca ctccacttta tcacacctcc cctaagaaac ctacatatag taaattattt 82260 aaagatagga gtggagaaac caaagaatct atgtaaaata taataatcca acagaatagt 82320 ttactttcca ttgcatgtat cacttgggtg cagtaacttc ttaggactct gagcgccgct 82380 gttcacctac taggagagaa aacgcagcca gagctcaatc cggattctca gggcttcaac 82440 tacacaagcc ccacaaaccg gctgctgggc tgcagggaag ctcactccag aatttaaagt 82500 gcccaggcta cagagacacc ctgaagccac agaaagacaa aggaaccggt tgaaacacac 82560 aacgtgtcca gtgaggactt tgcagaattc tgtaaccaga ctacaatggc cgctcaaagg 82620 aatcgctcaa aggaatcaaa ggattgcagc gggctggtcc tgctctgcct tttcttcggg 82680 attccatggg aggctggagc ccggcagatc tcctactcaa ttcctgagga attagagaaa 82740 ggctctttcg tgggcaacat ctccaaggac ttgggtctgg cgccccggga gctggcggag 82800 cgcggagtcc gcatagtctc cagaggtagg acgcagcttt tctctctgaa cccgcgcagc 82860 ggcagcttga tcaccgcggg caggatagac cgggaggagc tctgcgctca gagcgcgcgg 82920 tgcgtggtga gttttaatat ccttgtggaa gacagggtga aactttttgg gatagaaata 82980 gaagtaactg atatcaatga caatgctcca aaattccaag cagaaaatct agacgtaaaa 83040 attaatgaaa atgtcgctgc gggaatgcgt tttcctctcc cggaagctat tgatccggat 83100 gtgggcgtga actccctgca gagctatcag ctcagcccca ataagcactt ctccctaaga 83160 gttcagagcc gtgccaatgg cgtcaagtac ccggagctgg tactggagca ctccctagat 83220 cgcgaggaag aggccattca ccacctggtc ctcaccgcct ccgacggggg tgaccctctc 83280 cgatctggca ctgtccttgt cagtgtgact gtcttcgatg caaatgacaa cgcgccggtc 83340 ttcaccttgc cagaataccg agtgagtgtt cctgagaatt tgcctgtggg cactcagctg 83400 ctgacagtca cagccaccga cagggacgaa ggtgccaatg gagaagtgac atattcattc 83460 cgaaaattac ctgacacgca attgttgaag ttccaactaa acaaatatac tggagaaata 83520 aaaatatcag aaaatctaga ttatgaagaa accggtttct atgaaataga aatacaagca 83580 gaagatggag gagcatatct tgcaactgca aaagtgttga ttacagtaga agatgtaaat 83640 gacaacagtc cagagctgac catcacgtct ctatttagtc cagtgactga agattcacct 83700 ctgggaacag tcgtagccct tttaaatgtg catgatttag actctgagca gaatggacag 83760 gtaacctgtt ccattttggc gtatctacca tttaaattag aaaagtccat tgacagttat 83820 tacagattgg tgatacacag agcccttgac agggaacagg tatcctctta caatatcaca 83880 gtgacagcca cagatggggg aagtcctcct ctatcaacgg aagctcactt tatgctacaa 83940 gtggcagata tcaatgacaa cccacctacc ttctctcaag tctcctactt tacctatatc 84000 ccagagaaca acgccagggg tgcctccatc ttctcagtga cagcgctgga cccggacagc 84060 aaagagaatg cccagattat ttactccctg gctgaagaca ccatccaggg ggtacctctg 84120 tcctcataca tatccatcaa ctcagacact ggcgtcctgt atgcactcag atccttcgac 84180 tatgagcagt ttcatgagct acagatgcag gtgacagcca gcgacagcgg ggatcctcca 84240 ctcagcagca acgtgtcgtt gagcctgttt gtgctggacc agaacgacaa tgcgcccgag 84300 atcctgtacc ccgccctccc cacagacggt tccacaggcg tggagctggc gccccgctcc 84360 gcagagcccg gctacctggt gaccaaggtg gtggcggtgg acagagactc cggccagaac 84420 gcctggctgt cctaccgtct gctcaaggcc agcgagccgg gactcttcgc ggtgggggag 84480 cacacgggcg aggtgcgcac ggcgcgagcc ctgctggaca gagacgcgct caagcaaagc 84540 ctcgtagtgg ccgtccagga ccacggccag ccccctctct ccgccactgt cacgctcacc 84600 gtggccgtgg ccgacagcat cccccaagtc ctggcggacc tcggcagctt cgagtctcca 84660 gctaactctg aaacctcaga cctcactctg tacctggtgg tagcggtggc cgcggtctcc 84720 tgcgtcttcc tggccttcgt catcgtgctg ctggcgcaca ggctgcggcg ctggcacaag 84780 tcacgcctgc tgcaggcttc aggaggcggc ttgacaggtg tgtccggctc gcactttgtg 84840 ggcgtggacg gggttcgggc tttcctgcag acctattccc acgaggtctc tctcaccgcg 84900 gactcgcgaa agagtcacct gatcttcccc cagcccaatt atgcggacac gctcatcagc 84960 caggagagct gtgagaaaaa cgatcctttg tctttgttag atgattcgaa gtttcctata 85020 gaggataccc cattggttcc agtgagtttt attttcattt ttacttttgt taaaaaaaaa 85080 aagattggtt tttactttga agtttgcggc atgatggtgg aaagtgtaaa tgctaaaaca 85140 ctgatgagta gaatttgatg tttattaagg tttttttttt tttttttttt tttttttttt 85200 ttactttctg gtaaaattca cctagtctca atcaaggcct atatatcata aggctttgtt 85260 atgattagct ttgcagaacc ttgtagttta tagtgttgtt gagtacaata ttgacaattc 85320 ctaagacaga cttccataca gaagtgcctg tcaatttata tttcctcctg ggtggtcaca 85380 tattgaaact ccagcccctt aagcaaccct cttgttctga aggcaggtct ggtaagaata 85440 ggtaagtatc agaaagaaat cacctctgga aacacaaccc aaatccaaga atactcaatg 85500 cagttcttcc caaggagaag ggcaataggc ctttttcaaa ctacatttta tatatttttc 85560 aatctatact ttgtggtgat agttgcagtt gaatatacta agtttttcat taatattgaa 85620 ttaacaattt atttataaca atgtatgctt agatttttcc agccctattt ataactgata 85680 acactgcagt atcctttttg catacaattc tctaatttca cactgctatg tggaagatat 85740 agcattttaa tttaactttc attgctcaat agggatcctg aggaggctat agagggtgaa 85800 attaagaata tttgggattc tgcttttgtc ttttttgtta aattttctag tgactaaggc 85860 tgaaagtaaa tatgggttgg gaagacagat aaatttgtac atgttcccga gaacaggagc 85920 aagagatata tgacaaagct atttcagtgg ctctttaatg tataaggagg caaacacctg 85980 aaactctgaa aactctgaaa ttgagaggca aaataaactt agagtcaaga aagaaatgcc 86040 atttctgcag atcagaatat aaacaccaac cacagctgta aaaaagaaaa gaatatatgc 86100 aacgaaggga aattatataa acaaaggatc attggaggta ctgatgagtt catttagttc 86160 aatgaaaata gtgacgtatt aggtagatct cttaatttta ttactagtat tctactaaat 86220 gtggtagtat aaagtcaaaa agcattccga agtttctcaa gacccttata attccatgat 86280 ttttttcagg tcagtcaaca tttgttgaat gataggtctg tggaaggaaa gcacactctt 86340 tagggtcata gttattaact attaaaccat tgaaactatt attttatatt tgtgttaatg 86400 agagtcaaaa ttattgtgca ttcatctcaa ataattctat tattttgaaa aatacaggtt 86460 ttttttttaa aaaaaactgc tcttgacatt gtagctattg tgagaaaata ttttgattat 86520 aattatttaa aagcaataca ggacaccctg gatgatggta atgactaggg caatggttgc 86580 attccagtac ttaagtatga aataaggaat tattactttc tgggtgaata taggctagaa 86640 ttgaagacaa aaaaatttgt tgcttatctt cagtacttcc agcttcatag ataattactc 86700 ttaaaaggaa caagaatgac tgcctctgga tggaggaatt ggatagcaat gggccgtggg 86760 ataggagacc tataaacctt catgctatat tattttgtgc ctttttaaat tttgaagaaa 86820 aaatattcat ttattcaaga tatatgtaaa ttcagtaaat aaaaagatat gatagttatg 86880 accaagtgga aatatatttc ctgatgtaaa aggaatcact gaggaaaaag attaaaatat 86940 tttggctgtc aactcgtagt ttaaaaaaaa ttccttgaaa gaggtagaga aaagtcaagt 87000 tgcagtccca cacagagcct ctgggcgccg ccgtcggcca gtgcagagca agcgctgacg 87060 ccggggatcc ctcagcctct agcctgggat tccctgcgca gccaacaaca gaaaagaaaa 87120 ccagctccca cacagaggct cccggctgcg cagaccttgc ccagcacacc agattgccag 87180 ctccgagacc cgggactcct cctgtcctgg gccgaatgct cttttagcgc ggtagagtgc 87240 actttctcca actggaaaag cggggaccca gcgagaaccc gagcgaacga tgggagggag 87300 ctgcgcgcag aggcgccggg ccggcccgcg gcaggtacta tttcctttgc tgctgccttt 87360 gttctacccc acgctgtgtg agccgatccg ctactcgatt ccggaggagc tggccaaggg 87420 ctcggtggtg gggaacctcg ctaaggatct agggcttagt gtcctggatg tgtcggctcg 87480 cgagctgcga gtgagcgcgg agaagctgca cttcagcgta gacgcgcaga gcggggactt 87540 acttgtgaag gaccgaatag accgtgagca aatatgcaaa gagagaagaa gatgtgagtt 87600 gcaattggaa gctgtggtgg aaaatccttt aaatattttt catgtcattg tggtgattga 87660 ggatgttaat gaccacgccc ctcaattccg gaaagatgaa ataaacttag aaatcagtga 87720 atccgtcagc ctggggatgg gaacaattct tgagtctgca gaagatcctg atattagtat 87780 gaattcgctg agcaaatacc aactaagtcc taacgagtat ttctcattgg tggagaaaga 87840 caatcctgat ggtggcaaat atccagaatt agtattgcag aagactctgg accgagaaac 87900 gcagagcgct caccacttgg tactgaccgc cttagatggt ggggaccctc cccgaagcgg 87960 tactgctcag ataagaatcc tggtaataga tgccaatgac aaccccccag tgttcagcca 88020 ggacgtgtac agggttagcc ttcgggaaga cgtgcctcca ggcacctcca tcctgagagt 88080 gaaggccact gaccaggacg agggcatcaa ctcagagatc acttattcct tctttggtgt 88140 ggctgacaaa gctcagcacg tgttctctct ggattacact acaggaaaca ttctaactca 88200 gcagcctttg gattttgaag aagtagaaag atatacgata aacatagaag caaaagaccg 88260 aggatctctc tcaacacggt gtaaagtaat tgtagaagtt gtagacgaaa acgacaacag 88320 cccagaaata atcatcacgt cactctctga tcagattatg gaggattccc ctccaggagt 88380 ggttgttgcc ctcttcaaaa cacgggacca agactcaggg gaaaatgggg aagtcaggtg 88440 tagcttaagt agaggtgttc catttaagat tcattcttct tctaataatt actacaagct 88500 agtaacagat gaggccctgg atcgggagca gaccccagag tacaacgtca ccatcgcagc 88560 cacagacagg ggcaagcctc cgttatcctc cagcaaaacc ataaccctgc acattactga 88620 cgtcaatgac aacgcgccgg ttttcggaca gtcagcctac ctggtccacg tgccagaaaa 88680 caaccagccg ggtgcctcca tagcgcaagt cagtgcctct gacccagact tcgggctcaa 88740 cggccgtgtc tcctactctc tcattgccag cgacctggag tcacgaacgc tgtcgtccta 88800 cgtgtccgtg agcgcgcaga gcggggtggt gttcgcgcag cgcgccttcg accacgagca 88860 gctgcgcacc ttcgagctca cgctgcaggc ccgcgaccag ggctcgcccg cgctcagcgc 88920 caatgtgagc ctgcgcgtgt tggtgggcga ccgtaacgac aacgcaccgc gggtgctgta 88980 ccctgcgctg ggtcccgacg gctccgcgct cttcgacaca gtgccgcggg ccgcgcagcc 89040 aggctacctg gtgaccaagg tggtggccgt ggacgcggac tcggggcaca atgcctggct 89100 gtcctaccac gtggtgcagg ccagtgagcc cgggctcttc agcctggggc tgcgaacagg 89160 cgaggtgcgc atggtgcgtg ctttgggtga caaggactcg gtccgccagc gcctgctagt 89220 cgctgtaaga gatggaggac agccacccct ttcagccact gccacgctgc acctggtgtt 89280 cgcagatagc ttgcaagagg tactgccgga tttcagcgac catcccacac cctctgactc 89340 ccaggctgag atgcagtttt acctggtggt ggccttggcc ttgatttctg tgctctttct 89400 cctcgcggtg attctagcta ttgctctacg cctgcgacag tctttcagcc ctactgcagg 89460 agactgcttt gagtcagttc tctgctccaa gtccggacct gtgggtcccc ccaactacag 89520 tgagggaacg ttgccctatg cctataattt ttgtgtgcct ggggatcaaa tgaatccaga 89580 atttaatttt ttcacatctg ttgatcattg tccagccaca caagataacc tcaacaaaga 89640 tagcatgcta ctggctagca ttttaactcc cagcgttgaa gcagataaga agattcttaa 89700 acaggtaagt atttaaaaat gtatttaatc ctttttatat tacaatatgc caatatattc 89760 caatatagtg gtattatttt aagattctag ataacttctt catagagttc gcaaaatata 89820 ggtcaaattt atggttatca ttattaaaac aaaagtttaa attaaatgcc tcagtcttcc 89880 tactattcaa agacatttta aagcaaacta catgggtaat ctccggtgac atttttatga 89940 agtaaaatac ctttcggtta aaaatataaa atacaggtat atttttacgg catggtattt 90000 taattgaaac cctgatgcta ctcaattttt ctcaagtatt tcatcttcat ttactcaata 90060 aaggaacctt gtaagaatta tagttaggca tcctacctga tgattttatc gggaccgtat 90120 tatttccact tccagaaatg tcgttccttt cagtcggtta aaatcaattg gaaccaacta 90180 caacctacaa gttttcagct ccagtaatat tttgaaaact ttttaaaaat taagcaagcc 90240 cttttaataa ttactccttt cgcaggtgtt cttggtaaag ttttaacgtc acataatgta 90300 agtattgtgt atcatcgttt ttaagctcta caaatacgtg tgattcacaa aggtgagcgt 90360 aatcatttct tctggaattt cttagtcgtt gcaataataa gaatgggctc taggcgccgc 90420 tgctcaccaa tcagggaatg ggaagctgcg cgccattgag tccctccctc ccccgcctct 90480 accacacaaa gcggaatgag atggatactc acagatcctg acactggaga cttagaagta 90540 ttttccttcg ctttctgata tattttggat gtagtcggcc taggacttca tagatacata 90600 agccgattca caaccaacca gctcgagaaa ccgcggaata tcggcttaga gcctgccatg 90660 gcgaatcggc tacagcgcgg ggaccgcagt cggctgctgc tgctgctgtg cattttcctg 90720 gggacgctgc gggggttccg ggccaggcag atccgatatt cggtgccaga agagaccgaa 90780 aagggctcct tcgtgggcaa tatctccaag gacctggggc tggagccccg ggagctggcg 90840 aagcgcggag tccgcatcgt ctccagaggg aagacacagc ttttcgctgt gaatccgcga 90900 agcggcagct tgatcacggc aggcaggata gaccgggagg agctctgtga gacggtgtcc 90960 tcctgttttt taaatatgga acttctcgtg gaagacacct tgaagattta cggagtggag 91020 gtggaaataa tagatattaa tgataacgcc cccagcttcc aggaggacga agtggagata 91080 aaagtcagtg agcacgcaat tcctggggcg cgatttgctc ttcctaatgc tagggatcca 91140 gatgtgggcg tgaactccct ccagagctac cagctcagcc ctaataatta cttttccttg 91200 caactgcggg gcagaacgga tggggccaag aatccagagc tagtactgga gggaagcctg 91260 gaccgagaga aagaggctgc tcacctgctc ctcctcacag ctttagatgg aggcgatccc 91320 atccgaaagg gcgcagttcc cattcgtgtg gtggtcctcg atgtaaatga tcacatccca 91380 atgtttacac agtccgtata tcgcgtgagt gttccagaaa acatcagctc cggaactcgg 91440 gtgctgatgg ttaatgcaac ggatccagac gagggaatca acggggaagt aatgtattca 91500 tttcggaaca tggaaagcaa ggcttctgaa atattccaat tggattcaca aactggagaa 91560 gttcaagtac gggggtctct ggattttgaa aaatatagat tctatgagat ggaaattcaa 91620 ggccaagatg gtggaggtct ctttaccacc acgacgatgt tgatcactgt tgtggatgtg 91680 aatgataacg ctccagaaat aactatcacc tcttctatta attcaattct ggaaaactct 91740 cctccaggta cagtgattgc tcttctaaat gtgcaagatc aagattctgg agaaaatggt 91800 caagtctcct gttttattcc taaccacctg ccttttaaat tagaaaagac ttatggaaat 91860 tattacaaat tgataacaag cagagtgctg gacagggagt tggtccagag ctacaatata 91920 acgttgacag ccacagacca gggaagcccg cctttgtctg cagaaactca tgtctggctg 91980 aatgtggcag atgacaacga taaccctccc gtttttcctc actcctctta ctctgcctac 92040 attcccgaaa acaaccccag gggtgcctcc atcttctcag tgaccgccct cgacccggac 92100 agcaaacaga atgccctggt cacttactct ctgacggatg acactgtcca gggggtgcct 92160 ctgtcctcct atgtctctat taactccaac actggtgttc tctatgccct acaatccttc 92220 gactatgagc agtttcgaga cttagaactg agagtgatag cacgtgacag cggggacccg 92280 cccctcagca gcaacgtgtc gctgagcctg ttcgtgctgg accagaacga caatgcgccc 92340 gagatcctgt accctgccct ccccacagac ggctccactg gcgtggagct ggcgccccgc 92400 tctgcggaac ctggctacct ggtgaccaag gtggttgcgg tggacaaaga ttcaggccag 92460 aacgcctggc tgtcctatcg cctgcttaag gccagcgagc cgggactctt cgcggtgggg 92520 gagcacacgg gcgaggtgcg tacagcgcgg gcactgctgg acagagacgc gctcaagcag 92580 agcctcgtgg tggccgtcca ggaccacggc cagccccctc tctcggccac cgtcacgctc 92640 accgtggctg tggccgacag catccccgaa gtcctggcgg acctcggcag cctcgagtct 92700 ctggctaact ctgaaacctc agacctctcg ctgtacttgg tggtggcggt ggccgcagtc 92760 tcctgcatct tcctggtctt tgtcatcgtg ctgctggcac tcaggctgtg gcgctggcat 92820 aagtcacgcc tgctgcaggc ttctgaaggc gggttggcag gtatgcccac gtcacatttt 92880 gtaggcgtgg acggggtaca ggctttcctg caaacctatt cccacgaggt ctctctcatt 92940 gcggactcgc agaagagtca cctgattttc ccccagccca actatgggga cacgctcatc 93000 agccaggaga gctgtgagaa aagcgagcca ctcttgatag ctgaagactc agctatcatt 93060 ttaggcaaat gtgacccgac aagtaatcag gtgagattta tttctctgcc tcctaattgt 93120 tggtgtcttg gcacaagtct tttaaggaga tgttttttga gcctgttatg aaaactgttt 93180 gggggggggg tggggcggca tatatttagt tcatatatat ttagagcaat acatgtgagt 93240 tttactttgc ctttcatgag attacgataa tctttcagaa cgtttttgtg aaagtcattt 93300 ttcaatcttg gcatattttc ttttgatttc aaaggggcca ttcaactatg ctggtttggt 93360 ttgaagtaag ttgaatttta gtattatttt tctattatca gtgtatgagg ctctcaattt 93420 attatatata gatacaaatt aatgattcac aaacactttt tatttccatt tcaattttgc 93480 tgtgccttca ctgatttgta gttatattcc accattattt gctattactg ctaatgttca 93540 aattttgatc ctgttgattt aatagcatgc tccctctagc tctccttctc atctatctat 93600 ctatacacat gcacacacac ttatacacgt aagcttttct ctgagcaatt ttattttgat 93660 tcttggtggc tggtaatatg cttagatcct gttgactatt tcaactttgt ctcatttctt 93720 catcctatca acacagacat attgactggc ttttaactac tggatttcct tgggagataa 93780 aatttagatc acattttttc ttaagctcta gatgtctttt ccattactat ggtgaagtta 93840 cattgactgt tctgaggaaa taattgaatt attgaactgg tattatttcc ttttattctt 93900 ttactttggt gtctgtgttt gtatgtatgg aaggtttttt aatgtagtaa atccatatat 93960 agaaataact tgattttgat tcagtgcttc tcaaaaacct attttcaaat gtgctaaaga 94020 tgtctacaga tttattcaaa tagagtagtt tgtgaatata taaatagatt gaaggtattt 94080 ggactttaat taaactgatt tagctagtat ccttctggct atttttttgt tcattttcag 94140 tgtagttggg agtcatagat tccttctttc tttctttata aggtcattct tatggcaaat 94200 agtacattca gttcttttat tcagaccaac ttgttattga agcttgatag ttgcctgaca 94260 tacatgttat ctgaagcaat gtctaggaaa gccaaatgag gaaaggagac ttatctaggg 94320 tttttgatca caggaatcat ttccataatc aattcagtca acactctcac atcacttcta 94380 ggtatttgcc ccaaattact tggatattta tgttcccttt caagtttagt tttctcattt 94440 aggaatttac cttatgtcat tagttgtaaa ctgactatct agggctcgga caaaaataat 94500 ttcaactgta ggaaaggcaa gtcttccaac agatgcctac atttttcttg aagtcaagaa 94560 aaatgttcag gtattttgag catctaggga taggatttat acttgtggaa ttccaaactg 94620 agaaaaatga tgtaaggcat tgtactttga ctggaattag ttaaataaaa aggatatgag 94680 gtatttggct gggaaaagga gattgttcca tattataaaa cctcatctaa actaacttcc 94740 caagatcgtg gagaacaaaa aggaagggtt ggctttgaaa tgtgatatta agagggttat 94800 gttgattcgg aggtagtgat aaagttctgt taaggtataa catatagtcc cattaaatag 94860 aggataaaaa taaaacacca tcacatttca tgttattaat tcctatggca acctactagg 94920 ctataccttt atattctctt tatgatgaaa catgaaacaa taatcctttt cagaaacctc 94980 ttttataagt gataagaagg gtttggctaa ctttattctg aatatgccct atatagcttt 95040 cagtgctcct ccagttttct ctgataaaac taggaggaaa attatctgca catcagattg 95100 aaaataatac tgcatatcat ttcatagtgg tcaaaatttt cccataccac ttgatgggga 95160 tgttttccca caaggttttt gttctacaac aggagagaag actttgccta gttcttccaa 95220 tatgtgcatt gcttctgctt agaaaaaaac aaacttttaa attctctttg ctgggttaat 95280 gactgttcta tagattccca tctctaagga atcttctttg gtagtaaaca ctggaaaaca 95340 gtcactacga aaactcataa aatgtctagt ttcctataca ttagtccaac acatcagtct 95400 aattctgaat cccattgaat tagcaaaggc ttccggctgc agttttctaa atagactcag 95460 agccctgctg ttggccaatg tgctgcaaga actggagcct gggatctacc aggacgatat 95520 tctgttcagt cacagaagca agtcggagag tggccaagac ttgggctttc tgctcctgca 95580 aatctgattc catacggatt ggggtgccct caaactggga gcattgagtt ttctatgtat 95640 ggaagtaaat attttaaaag cactttgtga aacattttct cttaacgtcg gagactgcag 95700 caacgcatgg gaaggatggg aaacagggtg aagcagagaa gcaggacccg gcagtggcaa 95760 gcactcttcc ctttcctgct gcctttgttc tgcggggcac cctcggagca gatccgctac 95820 tctattccag aagaaacggt ccagggctcc gtggtgggga accttgcgga ggacatgcgg 95880 ctgcatgttc aggatttatt gacctgaaac cttagagtta gtgcagagaa acaatacttt 95940 accgtgaaca cggagaatgg gaacatactt gtgagtgaca gaatagatcg agagtcactg 96000 tcttcaaaat cctctgtgtc atacccttag agattgtagc agagaatcct ctaaatgttt 96060 ttcacataaa tgtgatgata gaagatataa atgataaccc acctcatttt ccccaaaata 96120 gcattgtttt acaaatcaat gaactagcaa ttccaggcat tcggtttggc ctggaatctg 96180 ctatagatgc agatgtaggg cctcactctc tccagagtta ccagctcagt tctaatgaac 96240 atttctctct gatgatggac aagactaaag gcaagaacgc tccagaatta gtgctggaga 96300 agcccctggg ccaggagcaa cagagctctc atctcctggt cctggaagca atggacatgg 96360 gtgacccagt cccaactggc actgctgcaa ttcaaattga ggtcactgat gccaacgata 96420 atgccccagt ttttagccag gatgtataca aagtcagcct tagagagaat gtgcccccag 96480 gcacctctgt actaaaggtg acagccactg accaggatga gggtgtcaat gcggagatca 96540 cctactcttt caaatcccta cgagatgata ttggaaatat gtttgtgcta gaccatcaaa 96600 atggggaaat taaatccaaa gacttaatag acttcgaatt tcgtagcagt tataccatga 96660 gagtagaagc taaggatggt ggaggcatga ccagcgaatg taaaattata ctagaaatcc 96720 tagatgagaa tgacaatgcc ccagacgtgg tttttacttc agtgtccagt tctgtaactg 96780 aggacgcaga accctggacg gtgatcactc tgttcaaaac acatgataaa gattcgagag 96840 aaaatgggga ggttacatgc ctcataaacg aaagagttcc ttttagaatc gaatcttccg 96900 ccaataatga ctataagctt gtaacagatg ggaccctgga ttgggagcgg atcccggagt 96960 acaacgtcac catcactgcc actgacaagg gcaagcctcc gctctcatcc agcacaagcc 97020 tcaccctacg cattggtgaa gtcaacgaca atgctccggt tttccaccaa gtctcctacg 97080 tggtccacgt ggccgaaaac aaccttcccg gagcctccat cccacaagtc agcgcctctg 97140 acctggacct agggctgaat ggccaagtct cctactccat cgttaccact gacttggagc 97200 tgcgggcact gtcgtcctac gtgtccgtga gcgcacagag cggggtggtg gtcgcgcagc 97260 gtgccttcga ccacgagcag ctgtgcgcct tcgagctcac gatgcaggcc cacgaccagg 97320 gctcgcccgc gctcagcgcc aacatgagcc ggcgcatgtt ggtgggcgac ctcaatgaca 97380 atgtgccgcg ggtgctgtac cccgcgctgg ggcccgatgg ctccgcactc ttcgatatag 97440 tgccacgcgc cgcagagtcc ggctacctgg tgaccaaggt ggtggcggtg gacgcagatt 97500 cgggacacaa cgcttggctg tcctaccacg tgctgcaggc catcgagccc gggcttttca 97560 gcctggggct gcacacggga acctgctggt tgctgtgcgt gacggaggac agccgccgct 97620 ctctgcgccg ctacgcttca cctagtcttc gcagacagcc tgcaggaggc actgccagac 97680 ttcagtgaca gtcctgtgcc ctctgattcc caagcaaagc tgcagattta cctggtcgtg 97740 gccttggcct tgatttctat gctcttcttc ctcgcagtga ttttggcggt cgccttgcac 97800 ctgcgatgct cttccagccc ctctgcctgg ggttgctttc accctggtct ctgttctaag 97860 actagaccag gggtttttcc caactacaat gagggaactt tgctttattc ctgcaatctg 97920 tatgttccct cggattctag aaaaagaaga tttaattttc tcaccatgac accagaaaca 97980 gtccccccac aagatctttc taatgaagtt tctctggtag caagcttcac tgaagagaat 98040 aacaagataa gctctaactc tgttgctcct actcacgtga gttccaatga atgtctttca 98100 tttacaaatg gatgaggttt aattttcaaa ccaatatttt ggcaagaaaa tcttaaacat 98160 attatatcta ctattgcttc aggtttgttt gcccactctt aatatttcct gttcctttct 98220 gtgtgggcca gtaacttcat tattagcttt catgtatttt tgaaacattt tcaccatttt 98280 tacgggagac tttttttttt tttggacgga gtctcgctct gtggtccagg ctggagtgca 98340 gtggcatgat ctcggctcac tgcaagctct gccttccggg ttctggccat tctcccgcct 98400 cagcctcccg ggtagctggg actacaggcg cccgccacca cgcccggcta attttttgca 98460 tttttagtac agacggggtt tcaccgtgtt agccaggatg gtctcgattt cctgacctcg 98520 tgatctgccc gcctcggcct cccaaagtgc tgggattata ggcgtgagcc actgcacccg 98580 gcccggagac attgtttata cacacacaca cacacacaca cacacacaca cacacgtgtg 98640 aaaagtgggt attatgatac tgctgtcatt gagatatttt aattgaggaa taaatttttt 98700 tcctgtgatg tttcttggga catcaatatt tgagtatata aggctttttc tttaatccat 98760 taactataaa ttttgaagaa aatgcatgag aaaatggaga aaatgtgttt tttttttaaa 98820 aaaaattgag attaaggtct cattatgttg cccaggctgg actcaaactc ttgggctaca 98880 gtaatcctcc cacctcaatc tccagagtag ctgagactac agttgcctga aactgtgcct 98940 ggcagagaaa aaagcttaaa aaaataagaa catggtaatg atttgataat attcagttac 99000 atttactttt gattcttgta attcaagtaa actcaatttt atgtctgata ttttctcaca 99060 gctacctata tatttcttcc caatttaaaa tatattattt tattttatgc ctagcaaata 99120 tctttacagt ataaatattt acgctcatga aagtacgtag ccagttattt cttagggaga 99180 attttttccc tatattttga tgggcttcca aaagtattac cagtaattct cagtaattac 99240 aattaggtca gttacccagg aaaaggtaag tctgtaacat tctttggact accaattttc 99300 ttttactaag tttcctgaac aataaatatt tttgaaatat aatgtattaa tagaattctg 99360 gagtacttcc attatttcca gtcaatgcaa gttggaatgc ttctacttta tgctaaaaat 99420 attaatgttt ctttttcact tgggttcttg ttaagtgtga ttctgataat gtatacaatc 99480 acatatcatt tttaggtttc cataatatca tgaaaatttg atttttaagc gttacatgtc 99540 aacaacctgg taaagtaatc cttccattca ggatcattca aggaatctat ttaaaaatat 99600 tttccccaaa ttatagctga atcagaaagt ttaaattatt atattatatg atttgtcaaa 99660 aagagaaact cctagggaga catctccata ataggtgtgt tgggggaaca gtaatctcaa 99720 agcagatgca ctaacattat aagattaaaa tcattgttta tagaaacttc caattcattt 99780 aaaagctcat tggggaaaaa aaagctcatt gggaaaaaaa aaaaaagctc actaaagttt 99840 ctattaaagc gaatacggta gatttccatc cccttttgaa gaacagtagg tggagctatt 99900 taagatataa aaacgaaata tcctttctgg gagttcaaga ttgtgcagta attggttagg 99960 actctgagcg ccgctgttca ccaatcgggg agagaaaagc ggagatcctg ctcgccttgc 100020 acgcgcctga agcacaaagc agatagctag gaatgaacca tccctgggag tatgtggaaa 100080 caacggagga gctctgactt cccaactgtc ccattctatg ggcgaaggaa ctgctcctga 100140 cttcagtggt taagggcaga attgaaaata attctggagg aagataagaa tgattcctgc 100200 gcgactgcac cgggactaca aagggcttgt cctgctggga atcctcctgg ggactctgtg 100260 ggagaccgga tgcacccaga tacgctattc agttccggaa gagctggaga aaggctctag 100320 ggtgggcgac atctccaggg acctggggct ggagccccgg gagctcgcgg agcgcggagt 100380 ccgcatcatc cccagaggta ggacgcagct tttcgccctg aatccgcgca gcggcagctt 100440 ggtcacggcg ggcaggatag accgggagga gctctgtatg ggggccatca agtgtcaatt 100500 aaatctagac attctgatgg aggataaagt gaaaatatat ggagtagaag tagaagtaag 100560 ggacattaac gacaatgcgc cttactttcg tgaaagtgaa ttagaaataa aaattagtga 100620 aaatgcagcc actgagatgc ggttccctct accccacgcc tgggatccgg atatcgggaa 100680 gaactctctg cagagctacg agctcagccc gaacactcac ttctccctca tcgtgcaaaa 100740 tggagccgac ggtagtaagt accccgaatt ggtgctgaaa cgcgccctgg accgcgaaga 100800 aaaggctgct caccacctgg tccttacggc ctccgacggg ggcgacccgg tgcgcacagg 100860 caccgcgcgc atccgcgtga tggttctgga tgcgaacgac aacgcaccag cgtttgctca 100920 gcccgagtac cgcgcgagcg ttccggagaa tctggccttg ggcacgcagc tgcttgtagt 100980 caacgctacc gaccctgacg aaggagtcaa tgcggaagtg aggtattcct tccggtatgt 101040 ggacgacaag gcggcccaag ttttcaaact agattgtaat tcagggacaa tatcaacaat 101100 aggggagttg gaccacgagg agtcaggatt ctaccagatg gaagtgcaag caatggataa 101160 tgcaggatat tctgcgcgag ccaaagtcct gatcactgtt ctggacgtga acgacaatgc 101220 cccagaagtg gtcctcacct ctctcgccag ctcggttccc gaaaactctc ccagagggac 101280 attaattgcc cttttaaatg taaatgacca agattctgag gaaaacggac aggtgatctg 101340 tttcatccaa ggaaatctgc cctttaaatt agaaaaatct tacggaaatt actatagttt 101400 agtcacagac atagtcttgg atagggaaca ggttcctagc tacaacatca cagtgaccgc 101460 cactgaccgg ggaaccccgc ccctatccac ggaaactcat atctcgctga acgtggcaga 101520 caccaacgac aacccgccgg tcttccctca ggcctcctat tccgcttata tcccagagaa 101580 caatcccaga ggagtttccc tcgtctctgt gaccgcccac gaccccgact gtgaagagaa 101640 cgcccagatc acttattccc tggctgagaa caccatccaa ggggcaagcc tatcgtccta 101700 cgtgtccatc aactccgaca ctggggtact gtatgcgctg agctccttcg actacgagca 101760 gttccgagac ttgcaagtga aagtgatggc gcgggacaac gggcacccgc ccctcagcag 101820 caacgtgtcg ttgagcctgt tcgtgctgga ccagaacgac aatgcgcccg agatcctgta 101880 ccccgccctc cccacggacg gttccactgg cgtggagctg gctccccgct ccgcagagcc 101940 cggctacctg gtgaccaagg tggtggcggt ggacagagac tccggccaga acgcctggct 102000 gtcctaccgt ctgctcaagg ccagcgagcc gggactcttc tcggtgggtc tgcacacggg 102060 cgaggtgcgc acggcgcgag ccctgctgga cagagacgcg ctcaagcaga gcctcgtagt 102120 ggccgtccag gaccacggcc agccccctct ctccgccact gtcacgctca ccgtggccgt 102180 ggccgacagc atcccccaag tcctggcgga cctcggcagc ctcgagtctc cagctaactc 102240 tgaaacctca gacctcactc tgtacctggt ggtagcggtg gccgcggtct cctgcgtctt 102300 cctggccttc gtcatcttgc tgctggcgct caggctgcgg cgctggcaca agtcacgcct 102360 gctgcaggct tcaggaggcg gcttgacagg agcgccggcg tcgcactttg tgggcgtgga 102420 cggggtgcag gctttcctgc agacctattc ccacgaggtt tccctcacca cggactcgcg 102480 gaagagtcac ctgatcttcc cccagcccaa ctatgcagac atgctcgtca gccaggagag 102540 ctttgaaaaa agcgagcccc ttttgctgtc aggtgattcg gtattttcta aagacagtca 102600 tgggttaatt gaggtgagtt tatatcaaat cttctttctt tttttttttt aattgctctg 102660 tctcccaagc tggaatgcag cggtacgatc atagctcact gcagcctcaa actcctaggc 102720 tcaagcaatt atcccacctt tgcctccggt gtaacaggga ctacaggtgc aagccaccta 102780 ctgtctgcct atctatctat ctatctatct atctatctat ctatctatct atctattact 102840 ttcttgtaca gacaggagtc tcactatgtt gagcaggctg atctgaaact tgggctcagg 102900 ctagcctcct gcttctccct cccaaactgc tgggattaca ggcgtgaacc acagtgcccc 102960 gcccttatca gatattcttt tctggctggg cgcggtggct cacgcctgta atcccagtac 103020 tttgggaggc cgaggcgggt ggatcacctg aggttgggag tttgagacca gcctgaccaa 103080 catggagaaa ccccgtctat actaaaaaaa tacaaaatta gccgggcgtg gtggtgcatg 103140 tctgtaatcc cagctacttg ggaggctgag tcaggagaat tgctttaacc tgggaggtgg 103200 aggttgcaat gagctgagat tgtgccattg cactccagcc tgggcaacaa gagtgaaact 103260 ctatctcaaa aaaaaaaaaa aaaaacttta tcctctagtt tcatccattg atgacacttg 103320 ctttaatcac ttattacaat cacctccaaa tgaagatttt ataattccat tgtttcttct 103380 acagttgtta attggctttc taccttgaag aagagtttta tattctctat atatgtttgt 103440 ttctatgatt ctggaagcat ggttttctat tttattcaat ggcctgtaat ctgttaatat 103500 caattattta ttttgatgct gaaattgtcc caggattggc ctttgggact ccctttaggc 103560 tgatttctat gtcctttctg ttacagcaag cttgggatta tatccaagat ttgtaattcc 103620 aatgtactta cttctgtcag tgtaaacaaa gtacgatttc tggactagat gacttgggca 103680 ttgtggggga ggtggaaatt agaggtattc tctgtttttc ctgtaggatc ttgcatttct 103740 tcctcttgct gcttgtctct ttgtgtcggg aacaggcccc ccaaaatctg gccataaact 103800 ggccccaaaa ctggccataa acaaaatctc tgcagcactg tgacatgttc atgatggccg 103860 taatgcccat gctggaaggt agtgggttta ccggaatgag ggcaaggaac acctggcccg 103920 cccagggcag aaaactgctt aaaggtgttc ttaaaccaca aacaatagca tgagtgatct 103980 gtgccttaag gacatgcccc tgctgcagat aactacctca atccatccct ttatttccgc 104040 ccatctcttc gtttcccata agggatactt ttagttaatc taatatctat agaaatgatg 104100 ctaatgactg gcttgctgtt aataaatatg tgggtaaatc tctgttcagg gctctcagct 104160 ctgaaggcta tgagacccct gattccccac ttcacacttc taaaaaaaaa aaaatttttt 104220 tttctgagct tggagaaata tatcccttag tacacttggc atttataaag cagacatcaa 104280 taaatttata tatatgtgac agataccaac aacaatccag tccccttccc tcatacctta 104340 tttatgtaca tatattttat ataatagata taatttatta acaatttata aaattacttt 104400 gttaatactc tatatcattt tctagctgaa tttatcaatg ataatgctct tttcccactt 104460 ttattttttt cccattgacc atgcagcagt tttgtgtaga ccgtctgata acaactgatc 104520 tgtttatcta ggggggagaa atctaattca atggaaaata taaataaaat tgtgataaac 104580 ttttgtaaat agagtggctt ttaactacac ttgagatggc tagcaaattc ataaagtgaa 104640 tttactttct ttcaaagttc agtaattctt tctggccatt agggatatgt ccatttatac 104700 tttctcagta tcccaagtca tttcatggtt ttaaatcatt catgaacttc caaatatagt 104760 gaatttattt cttctgcatt taaaatttta tcacttaaat atacaatata ccgtattgcc 104820 atgacgaaaa atggtaaaga ctatttttca cttctgttat gcatttcatt aatacgatat 104880 ctgtatgtgt ttccaagtta gacatttctt ttgcccattt cctacactaa tgatactaat 104940 gatgactttg tggaatattc agaattaaca aaatgtgttt tgagtgcttt ttttagtact 105000 ggggcaaatt tgcagtaata tcgcctgctt tttacattaa attccccata acttttacaa 105060 ctatgggaaa atttctgaaa cgtgcacaga ttccaagtgt tttctgagaa ctttatgctt 105120 attgtagagt ggttacagac actgaatgct aaagtgtatt actctttgaa aagcattgct 105180 tgatttcttt tggtgaattc tgtaaaggtg cagggaaaca taacgtccca attatttttt 105240 ctttcttctt tgtttgctgc ctatctactt tgaaagatac aatagttaaa acccagaaaa 105300 gagattggaa accccttaga gaatgaaaga catccaaggg ctctaaaatg cggcagttgc 105360 tgcttctgag accaaaaaag ggggcaaaat atagagtgtg tggttctact tgtgtgattt 105420 tttgaaagaa agtatttgaa tttatctaaa aatactaaat ttgtatttac attagttttc 105480 aaatagaatt taataagtac agtgttctat aggtaatatt gagagaaata gaggacaatg 105540 aaacctctct cctccatcat cttgtatgaa ctaccaaaat gtttatcata tggacagttc 105600 tcatatatag tcaaatagaa agaaagacat aataggaaaa caaatgactt gggaaactaa 105660 gctaacatgg tctaattatt ctgacctctg ctcacctaac ttgatttagg aacaaatcat 105720 tgagagttag agcatgaata gtcaagactg ttagaccata tctcaaatat cagtgacttc 105780 aatcaactat gtttccagtt taagctgaat aggctttatt aaatagttgt tgaatgaatg 105840 gataaacaaa taatgtactc tggggattac ctgataccag gattctgaat tttcagatgt 105900 atcatagaag gatagcagct ttgcaattag gtaaattgtt aactgtgtca cctttagcaa 105960 gttatttaat ctctttgagc ttcagcaaag taggaataat catatctaat ttgaaaggtc 106020 gtggtgatgg ctagggctaa caaaaatctg attcacaaca tgcaattaat taacagtagc 106080 catttttagt ggttgaccaa aaaaaggatt tatattttca atgccagcac actcgatgtt 106140 ctgttgggaa aaataataat gatttttgtg tgcttctcca tatggtataa tggaatgatt 106200 tgtggatgga aataaaactg ttctaaaatt tttgtgacag ctggtttaaa aatcttaagt 106260 gcctaggcac attcttgatt gagaagccac agttttaggc cataaaagat gggggaaaga 106320 tttttatatg agacaatttt gtgagtgtta ctttttcttt gtctgaacca tagtgaaatc 106380 taaacaagga tcttgtgaaa cttattttaa agaagcagtt tacttcaatg ggatcttaga 106440 taatttcacc agaaaatgga tcaccgaaac cagaaggctg gtgatcatta tttggtttgg 106500 gccatataag aattgaaact aacggcttag ctttaggatt tttaggacac ttgttgataa 106560 tttaggattc ataattaaca tatgtgttga ttgttttctg agactaactg ggcaatgggt 106620 ttggatgtgt ttacatttat tctgattcca gtcataaaat tatgtcaagg actttccttg 106680 tctttttatg tgtatgacag atgtgtatgt atccatttca tctaacaagt taaagcgttc 106740 agctataatt taaaatttgt agcttcactg ttttatagta cctaaaattg gaatgtaatc 106800 agtcagaaga cattcatcca ctgctttcat tccagaagta ttatgctttt tgaagcagca 106860 atagcatagg aatgttgagg agactatact atacttttat agcatattta atctcgtaga 106920 tcacttttca atgaattata aggctgatga caaatgagca aattgtatca gttttcttta 106980 tgacatgtaa cagagtatag ctgtgatcat gaattggata gttctggtgt aaaaatctgc 107040 tttatcccca tataagatgt caggttcaga aaagcaaaca catagtttcg aagagatgtt 107100 gatcaaactg atgaggctaa atctcaagaa agagacacag ttaccctcta atgttacact 107160 ttgagttcac cttttttttt ttttttgaga cagagtctca atctgtcgcc aagctggagt 107220 gcagtggcac tatcttggct cactgcaacc tctgcctcct gggttcatgc tattctcctg 107280 ccttagcctc ccgagtagct gggactacag gcacacgcca ccacacccag ctaatttttg 107340 tatttttagt agagatgggg tttcaccata ttggccagaa tggtcttgat ctcttgatct 107400 tgggatgcac ccaccccacc tcagcctccc aaatagctga gattacaggt gtgagccacc 107460 atgcccgacc actttgagtt cacttttaag aaaccatact taatggaaaa ttaccagtaa 107520 cagggcatac tgtttaggat gcattcctaa aatattaatg gcaaaagata gccagcctat 107580 ggcaaagcta attggaaaaa atattttata aaggatgaga cttctggata ccatatggga 107640 agggctctgg ttcaggaaaa tgtttttaaa aaactgtcat tgaagagacc atagaatcaa 107700 acaaaataat ttaatctgta tgtaaaagaa gttggtacca ccataatttt tcttatacat 107760 gtcatataag gatctactct gtgtattgtc attgagggca gatataattt cttagttcat 107820 cattaactct ctgaagtatt tcacacagta gtttgtacac cttctaagta ctcaatacaa 107880 tgcttgagtt caattattgg aaagtggtct cttggagaaa aaagaatcat agtgcaaaac 107940 caattatttt acatggactt ttcctctata tctaagccct aataagaggc agctgtctga 108000 tatacataca tacatacata catatatata tatatatata tatatatata tatatatata 108060 tatatacaca cacacacaca catatatgta tatatatatt tggagtaggg gatggagtct 108120 tgctctgtca cccaggctgg agtgcaagtg gtgtgatctc agctcactgc aacctctgcc 108180 tcctgggttc aagcgattct cctgcctcag cctctccagt agctgggatt acaggcgcct 108240 gtcaccatgc ccagctaatt ttttaaaata tttttagtag agacagagtt tcatcaagtt 108300 ggccaggctg ctcttgaact cctgacctca ggtgatccac ctgccttggc ctcccaaagt 108360 gctgggatta taggcatgag ccaccgcacc ctgccaactg tctgacttat cttaaaaggc 108420 taaggacctg gtttgtttgt caaattttga aaatagatgc ctcagttcat aagatttcca 108480 tattgtgtgg caggcgcctg taatcccagc tactcaggag gctgaggcaa gagaatcact 108540 tgaacccggg agacagaggt tgcagtgagc tgagatcacg ccactgcact ccagcctggg 108600 cgacatagtg agactctgac aaaaaaaaaa aaaaatccat atgtgaaaat tcttagaagc 108660 ttcctataca atttcagctg aagattcagc caacagttca ttctgagact gtgttccatg 108720 gaaaaagtaa agcccaggca tggaagtggg aatggaaaga aagattctaa gcctacaaat 108780 actcaaacat caagaagaaa taaaaataag tcatcacttc gacttcatgt gctaacatca 108840 ctgaggttat aaattcccag gaatatttta ttgcgggagc aagactgcac tgctgccttt 108900 cagcttgcaa attccagtga gaaacgtctt tctctctgct ctcaactaac tctacagaac 108960 gctgtcctct catttcttca ggctgcagtt ctagagtagg gactcagagt gccactgttg 109020 gccagtctgg aaacagagat aaatgagcca atccccagac attccggctt ggtggctttt 109080 ctaatttcat ggaatgcaaa tccaagagca gacccacaac attcctatta tggctcctag 109140 ttctacaaat tataagcagg aacggaacgg atttacaggc aatgagttca gctccttctt 109200 ggctggagat tctataatcc aagaagagtt tgaaaagggg cttatttggg ctggagcagc 109260 agcaactcta actgtggaaa aggtggggaa tggtgctgga ctgacagtct gggtagaacc 109320 aaggcgacta ctgcctcctt tcctgctatt tctatcctgc tgggcattct ctatgatgca 109380 gatccgttat tcagtcctag aggagctggc caagagtttg gtggtgggaa accttgccaa 109440 ggatctggga ctcagtgtcg aggacatgcc cacttgaaag cttcgggtta atgctgagga 109500 ataatacttc attctaagtg gggaaagtgg agacttactt gtgaatgact gaatggatca 109560 ggagcagata cgccccccaa ttatagcttg ggccataacg ctttgaaata gttgaaggcc 109620 aggcatggtg gctcacacct gtaatcccag cactttggga ggccgaggcg agcagattac 109680 gaggtcagga gttcgagacc agcctgacca acatagtgaa accctgtctc tactaaaaat 109740 acaaaaatta ctgggcatgg tggtgcaggc ctataatcct agctactcgg ggggccgagg 109800 caggagaatc gcttgaaccc gagaggcaat cgcaccactg cactccagcc tgggtgacag 109860 agcaaggcgc catctcaaaa aaaatgaaca aacggtagtt gaaaattctt taaatgtttt 109920 tcacattaat atggagattc aggatatgaa gaatcatgca ccacggttca gcaggaatgt 109980 tattaagtta cgtatctctg agtttaccca gctggaacaa gatttgcaac agaacctgca 110040 gaagatcctg atgttgagag aaattcctta caaaattatc accttagcag caactctata 110100 tttctctttg aagtaaaagt gaccaacagt ggaaagacat atgttgatcc tgtgttagag 110160 aagctgcttg actaggaaaa gcagagctcc catcccttag tgctagcagc cttagacggc 110220 cccccaacaa agcagcatca ctcaactcct gatcctattg gttgaagcca atgacaaccc 110280 tgtgttcatc taggatgtgt acagcgtcgg ccttcaggaa gatgtgcatc cgggcactcc 110340 tgtgctgaga gtgagggcca ccaaccagga ctagagtgtc aaggcagaga tcacatatgg 110400 cttcacaacc cagagtaccc atatctagtt tggccttgat caaatagtgg agaaatgaaa 110460 actttaagta cattggactt ttaaagattt ttaatttcca tggttttggt agcaagtgac 110520 agagagggac tcattgtcca gtgtacagtt gagaccgaat ttctagaaga taatgacaat 110580 atcctagagg cgatttttac ttctaattcc acaatgattc ccaaagattc tgcaccttgg 110640 acagtaatca ctgtccagga tttaaatcac aagatcttta aatcacaaga tctggattcg 110700 ggagaaaacg aggtcacatg tctgatataa gaaaatgcac cttgagaaaa atcttcctcc 110760 aataattaac tacatgcttg taacaaatgg ggccgtggac caggaacaga cccaaggtat 110820 aacatcagca tcactgccac tgacagaggc aaaccaaccc tctcgtccag cccaagcatc 110880 accctactca ttggcgatgc caacgacaat gctctggttt tctaccaggc ctcctacgtc 110940 gtccacgtgg ccaagaacaa tcttcccaaa gcctccatag tgtgcaagta gacacctcca 111000 acctagactt gggacccaac agccaagttc cctattccat cgtggccagt gacctggagc 111060 cacaggcgct gtgattctag gtgtccttga gcgcacagtg cgccttcgac caagagcagc 111120 cgcgagcctt caagctcacg ctgcaggccc gcgaccagga ctagctcgcg ctcggcgtca 111180 acgtgagcct gcgcgtgttg gtggacgacc tgaatgacaa cgcaccgcgg gtgctgtacc 111240 ccagctctgg agcgcaatgg cttcgcgctc ttggatatgg tgctgcacgc cgcggagcct 111300 ggctacctgg tcaccaaggt ggtggctgta gacgcagatg tgagacacaa tgcgtggctg 111360 tcctaccacg tgctgcaggc cagcaagccc aggctcttca gcctggaatg cgcaccgacg 111420 aggtgctgac agctcgcacg atgggccaca ggaaagcgac tcgccagcgc ctactggtcg 111480 cggtgcactg cggtggacag ccgctcctct cgctaccgcc acgtcaccac cactaccgcc 111540 cctcgtcgcc gacagcctgc aggagactct gccagacctc agcgatcact ctgcaaagct 111600 acagcctgaa tccaaaatta atttatatct ggtgattgcc ttagctttaa tttccttttt 111660 attcttcctg attgcattgt ttgtgctggt tttaaagtgc cgaagacccc aaaatgatcc 111720 tgtctgagtc tttcccacgg atgtctatcc cgcgctaagc cccaggtttc tgggtaactg 111780 tagctctatg atgccatatt cctaccaggt gtgtgcttct cctacgaatc cagggctgag 111840 tgaacttctt ttttgaatcc ctacccctca ggactcaata gcagtttcac tgcagaaagc 111900 cccttgggga aggggatgat tgtgattatt ctaattgctt gggcagaatc cactctccaa 111960 ggtgaaaaat tcttgatgaa actaagttca gtcacaagca ggttttcttc tagcattaaa 112020 tattttcaga gatctcagta aaaagcattt ctagcagcaa gaccaaaggc ctaagatgag 112080 aaatatttgg catggtgagc ttgagggaca gtagtcaggc agacaagagt atcagacatg 112140 ccagagcatt tggggcctgt aggtaaggag catgttttga ttatatatat ttgtatgtgt 112200 ttgattatat tttataattt tactttgata ttcaaattgt actgatccaa aaataaggga 112260 gggacaaatc ttggccattg tagtatgaga gatgtaaatt tacaactcag aatccctgct 112320 tatcacttct ccttcagcac acaactgttt cattttctat ttaagaaact tcctctcact 112380 gcaaaaagac attctggctg ataaagttag cctataattt cagtaaatct aagaatatga 112440 ctaatggaag ttgccagacc taaactttga aaattattgt tccactgaag agcgtcttat 112500 gactgagtgt tccagtctcc ttctcaagct gaaccttgct tttcaaacca gattaagaac 112560 actatcataa gttatactgc attttatttc cctacccatg tccactgcat cattctctat 112620 agtacaaaga gcttgtctcg ccaggcgcat ctataatctt agcactttgg ggcgccaagg 112680 cgggtggatc acttgagccc aggagtttga gaccagcctg gacagcatgg caaaaaccca 112740 tctctacaaa aaaaaaaaac aaaaattaac aaggtttagt ggtccatgcc tgtggtctca 112800 gctacttggg aggctgaggt gtgaggatca cctgagtctg gggagattga agctgcagtg 112860 agctgtggtt gcgctcctgt actccagtct gggtgacaga attagaccct gtcccaaaac 112920 aaacaaacaa ataaagagct tctctcctta tgacttattt aaagcttggg aaattgttcc 112980 aattcaaatg ctttaaatgg acttgagcta aaacagaatg tggtatatga aatgttctta 113040 taatcaggtg attgtaaaaa ttgatccaga taatgttagc atagcatttt actgaactag 113100 tagtttacaa acacttcaaa aattatagaa taacatttgc atataaaatt cctcatacat 113160 ttccctatca gtgaattgga agcttacaat atacaatatt accaaaaaga caaaaaaaat 113220 gaaaaggaaa cagttacctt tggaaaacat aattaggtaa aatgggtaat atggaaagtc 113280 tgaaaactga aaaaattact gataagtcaa gagaaaagga atattagtag gaaaattcat 113340 aaaagtgtgt ctgactactc acagcaggtt tccttattgg tatgtattct gtggtccatc 113400 taagctatgt taattttatt ttaaatgcta cctgggtatt ggcttctaaa aggaattcag 113460 taaatcagat aatttggcat cttcaatcta gattctgatg ctcacctgaa aagtctgcta 113520 aggattggaa accaagaaaa gtgaagtatc tcaacagata tgtgtcactt gtgtgtactg 113580 gatttttttt tttttttttt tttttttttt ttttttttga gatggagttt cactcttgtt 113640 gcccaggctg gagtgcaatg gcatgctctc ggctcactgc aacctccgcc tcccaggttc 113700 aagtgattct cctgcctcag cctccctagt agctaggatt acaggcatgt gccaccacgc 113760 ccagctaatt ttgtattttt agtagagacg gggtttctcc atgttggtca ggctagtctt 113820 gaactcccaa cctcaggtga tcttccctcc ttggcctccc aaagtgctgg gattacaggc 113880 atgagtcact gcgcccggtc gcgtactgga tttatattgt gtaatacttt gctctagcag 113940 tatagtaggt gagacagtga ctgtgtctag tgagcaaaag gcacttattt gacacttttg 114000 actcttcctt tctacttacc ttatttaaaa ttgatttttg catgtggcat gatgcaccag 114060 ttcattgagg taggggttga agttatttcc catttttttc aataccattt attaaaaata 114120 ttttcctctt tctgttgaat ttgcttggtg cctttgttga aagtcatttc actgatatat 114180 gtagttctat ttctatattc ttgatcatgt ttcatttgtc tattctttta ctaatagcac 114240 actgtctcaa ttattgtagc tttatagtaa gtcttgctac aaagtcttac tacaggacaa 114300 agcttgtagg atttttgaat gggatggcat tgcatctata cctttatcag ggaaagaggg 114360 aaggagggag gaggatcatc ttaacaatat tgacacttca aatccatgaa catggtatat 114420 atttccattt aattaggtct ttaatttctc tcagctatgt tgtatagttt tcagtgtaga 114480 gaggtcatgt atatttctca ttaaattgtc cctacatatt tgatgttttc taatgttatt 114540 gtaaatagta tttttaaaat tgtatcttct aattgttcat ttctagttta cagaaaaatg 114600 aaaaactatg tttttatgta ttctatatgc ttttgaaaag taagaggtgc aaagtgctct 114660 attcttacac tatattgtgt gagaatataa gtcgaaacca ctctgcataa gttcaggctt 114720 ccattctctt cagtttgtag gttgagagaa cccatccaga aacagtaaac attggtgtct 114780 gcccaagtct ggtcctgggt ggttcattca ttcatttaca taacaaatat ttattaactg 114840 tctgctatat gcaaggcact gacctatgga ctaaggatgc agcaatgaac aaggcatata 114900 tgattcctga gttaatgggc cctattctaa tacatgatat tttacaggtc tgataaaagc 114960 caacaaggag aaatacaaaa gcactaagag aaagcttata gtagggaagc ttcgcctaat 115020 ctgaaggtca aggaaggctt tctttttttc ggaaagtgat atttagagag atgaatagat 115080 taataggatg agtagaagtt atctaggtaa caaggaaagt aaaaaagaaa ttgtcaggca 115140 gaggaaatag catgtgtaaa gatcttttta aaaaataaaa ggtgtgactc aagcaattta 115200 aaagggctag ggaggctaga aacagaaaat aaatagatga aactaataag gcagggagag 115260 ccttgtaaat cacacttaaa attctggatt ttgttctaaa tacccttgta cttaggagct 115320 attaaaatat tttaaacaag gcagtgacaa gatatttgaa ttattaagct tactctggct 115380 gctatatgga gaattgattt atgagggtta taaatagaaa taggaagata agataggaga 115440 ctatggcaat attcctggta agaaatggaa gaagagctgg cttggattaa aggggaggca 115500 gtggatgtag aaataaatgg atgaattata gatatattta ggaaatgggt tcaataagac 115560 ttaataatgg aataggtgga atataaattt catgagggca gggggtgttt tgtttattat 115620 tatattccta ggtgtctgaa aatattgttg tgttgcctgg caagtggtag atcttcagtg 115680 aaatattatt aactgaataa atacaatgga taaatgggga gcagggatta agagtgattc 115740 ctgggtttcc acattaagga actggatgga caaagctacc atttgatgag aatggaagac 115800 taaagaatga tagatttaag agaaatcgag ttgagttcca gccatgttca tttgaaggat 115860 ctgagaaaca gtgcagatat tcagtgtgtg attagacata tggtcatcat tctttttttt 115920 ttttgagatg gagtctcgct ctgtcaccca ggctggagtg cagtggccct atctctgctc 115980 actgcaatct ctgcctccca ggttcaagtg attcttctgc ctcagcctcc tgagtagctg 116040 ggactacagg cgtgcaccac cacgcctggc taatttttgt atttttagta caagacagca 116100 tttcaccata ttggccaggc tggtctcgaa ctctgatctg cccgcctcgg cctcccaaag 116160 tgtggggatt acaggcgtga gccaccgcgc ccagccggtt accattcttt tactctgagt 116220 tcttccattg tgatcatcta gtcagatggg tagatcctta taaggctgag cataataagc 116280 ttcctgatag ctctacactg gtatgttttg gggttcatgg ctgagctact tttgtgtttt 116340 atttatcttc ctgatctctt tttcactgta agaaacatcc agcacccagg gaaatttgct 116400 gtctaattca tactccactc ttcagactag tcctagtgtt cagttttgtt ttgttttttt 116460 tctgtgtctg gaattctatt aaaatgtgtc aggctgtttt aatttttgtt gtttaatttt 116520 ctttcacatg attatatgtg ctccatggat ttttttgttt gtttgttttt tgtttttgtt 116580 tttgtttaag cggggtcttg ctcttgtcgc gcaggctgga gtgcaatggc ttgatctcgg 116640 ctcactgcaa cctccgcctc ccgggttcaa gtgattcttc tgtctcagcc tcccaagtag 116700 ctgggactac aggcacatgc caccacaccc ggctaatttt tgtattttta gtagagacgg 116760 gtttcatcat attggtcagg ctggtctcaa actcctgacc ctggtgatct gcccacctcg 116820 gcctcccaaa gtgctgggat tacaggcgtg agccaccgca cccggaggaa atttttaacc 116880 tcagtttttc ttcaccatct gtaaaactgc atagaaggaa tgtttaggat aaaagatgca 116940 taacaatcat aacaaaattg ttgggtttta atgttatgag tacacttgga ggattctatg 117000 tccacacata ccttaaacat cctatagagt ccttagcatt ttaaagttga aaccaacagt 117060 atgaatgatg gtagaatttt cccccccagg aagttagaac tgttccatat cttgatagag 117120 ggatgggtta taaggatgta cacattttcc aaaactcatt gaacttaaga gtcttgcatg 117180 tgactgtata taaattatac tttaattgaa aataaattta agaaaataaa attggctggg 117240 cgtggtggct cacgcctgta atcccagtgc tttgggaggc cgaggtgggt gaatcatctg 117300 aggtcaggag ttcgagacca gcctggccaa catggtgaaa ctctgtctcc actaaaaata 117360 caaaaattag ctgggcatgg tggcggacac ctataatccc agctactcgg gaggctgagg 117420 catgagaatc gcttgaaccc aggaggtgga ggttgcagtg agccaagatc atgccattgc 117480 tctccagcct gggcaacatg aacgaaatgc catcttaaaa aaaaaaaatt aaaagaaaag 117540 aaaattagcc tcccccaccc tcactatacc tcagactcac ccctgaaaga tcactactat 117600 tcatccctgg ttatgtacac ttacaaacat tttctgtgtg tatgcgaatg tatgtgtggg 117660 gttttctttg cacaacagga tcattttaca gtatatatac tgttgtgcaa cttgctcttt 117720 ccacttaata tctcaaggaa tcttttcttt gaatctttat agccatgtac ctcaatctta 117780 gtagttttct ttattttatt tttgaatagg aaatacattt acatggtttt aaaaatcaaa 117840 acaatatact atgtatatat tgagaagtct gacttccatc cctatcctac tcctattcca 117900 cccttgcttc ctcctgtccc ctgtaggtaa acattttata actttattaa gcatcctgtc 117960 agcatttctt atgcaaatat gtacatatat ttttatttcc ccattttttt tacaaaaaga 118020 taaaatacta tacaccactt tatatcttcc tttcttcaca ttatatcctt taaaaatatt 118080 tccatattgg ccgggcgcgg tggctcacgc ctgtaatcgc agcactttgg gaggccgagg 118140 cgggaggatc acgaggtcag gagatcgaga ccatcctggc taacacggtg aaaccccgtc 118200 tgtactaaaa atacaaaaaa aaaaattagc caggcgtgat ggcgggcgcc tgtagtccca 118260 gctactctgg aggctgaggc aggagaatgg cgtgaacctg ggaggcggag cttgcagtga 118320 gccgagatcg tgccactgca ctccagcctg ggcgacagag caagactgca actcaaaaaa 118380 acaaacaaac aaacaaaaaa gaacttccat attaatatat agaaagctgt tttttttaac 118440 agttgcttag cattcctttg gattattaac cagtctcata aatgagcgct attgaatagc 118500 cctgtaccta catcagtttt tacatatgca gtatatcttt gggatgaatt cccagaaatg 118560 gaattgaaat tgctgggtca aagaggaaat aggtgtaatt ttcttaggta ttttcacaag 118620 aagtgttaat tctaactttc tgttttgaaa tgatttcaaa ttttcaaagg agttgcaaga 118680 attgtacaaa gaactgtatc tccttcaccc ggatgcaccg ggtgaattat atgtattata 118740 taattgtatc tgtaggccag gtgcagtggc tcactcctgt aatcccagca ctttgggagg 118800 ctgaggcagg tggattactt gaggccagga gttcaagacc agcctggcca acatgataaa 118860 actccatctc tactaaaaat acaaaaatta gccaggcctg gtaccccatg cctaagggtg 118920 aggcatgaga aatgcttgaa cctgggaggc ggaggttgca gtgagccgag atcgcaccac 118980 tgcactccag cctgggcgac agagcaagac tctgtctcaa aaaaaaaaaa aaaaaaagta 119040 aaaaagtttt ttaaaaagat gtatctatat atacatattt acatacacac ccaagtgtgt 119100 atgtatatat gtttgtgtgt atgtacacaa acacattatt tttatatgat atgatttttt 119160 tatgacatga ttatttttat gacatttgag agtaagttgt agaaattatg tttctttatt 119220 cctaaatacc tcattgtgta tttcctaaca aggacattct tttatataat taaattttaa 119280 taataaaaat cagaaaattt aacatcaatg caatataatt atttagccta tagtccatat 119340 ttaaattcta ccatacctta tagtatattt tactatacct catagtaatt ttttttagtc 119400 caaaatatca cacattgcat ttagttgcca tgtctctttt tttttttttt ttttgagaca 119460 gggtctcact ctttcgccca ggctggaatg cagtggtatg atcttggctc actgcaacct 119520 ccgcctccca ggttcaaatg attctcctgc cttagcctcc tgagtagctg ggactacagg 119580 catgtgccac cacactccca ccacacccag ctaatttttg tatttttagt agagacaagg 119640 tttcactatg ttggccaggc tagtcttgaa ctcctgacct caagtgatct gcccacctca 119700 gctaagtgct gggattacag gcgtgagcca ccatgtgtgg cctagttgcc atgtctcttt 119760 aatctacttt aatctgaaac agttcctcag ccttgtttgt ttatatgaaa ctgacatttg 119820 taaagactag aagccatttg tcttgtataa tgcctttaat ttatatttgt tttatgtttc 119880 ctcgtgattt tatatataga gtttgtttgt ttgtttgtct gtttgtttgt tttgagatgg 119940 agtctcattc ttgtcaccca ggctggaatg cagtggcgca gtctcggctc actgcaactt 120000 ctgcctccca ggttcaagca attctcctgc ctcagcctcc tgagtagctg ggattacaga 120060 tgcctgccac catgcctggc taatttttgt acttttagta gaaacggggt tttgccatgt 120120 tgcccaggat ggtctccaac tcctgacctc aggtgatccg cccgccttgg cctcccaaag 120180 tgccgggatt acaggcatga gccaccgtgc ccggacctca tgattgtatt tatttattta 120240 tttaatatta ttattattat tttttttttt ttgagatggg gtcttgctct gtcacccagg 120300 ctggtgtgca gtggtgcgat atcggctcac tgcaaccgct gcctcccaga ttcaagcaat 120360 tctcctacct cagcctccca agtagctggg attacaggca tgtgccacca cacccggcta 120420 atttttttgt atttttttta gtagagacga ggtttcacca tattggccag gctggtctcg 120480 aactcctgac cttgtgatcc acccaccttg acctcccaaa gtgttgggat tacaggcgtg 120540 agccaccaca cccagcctta tgattgtatt tagactagac atttttttgg tagtatatta 120600 tttagccatt gctgtgtaac aaattatccc aaaacttagt ggcttaaaag aagcatttat 120660 tatctcataa attttgtgga tcaggactgg gtatagcttt gctgagtgcc tctgcctcaa 120720 agtcttacaa ggcagcaatt aaagtgtcac ctaaggctat tgtcttatct gaagggtcaa 120780 cagaggatgg atccgcttct aatctctctc acatagttaa tggcaaaatt aagttccttg 120840 tggattgtta gactaagggt tccagttcct tgctggttgt tagcttgagg tctacctcag 120900 ttccttgcca tgtggacctc catagggcaa ccagcttctg ttagagcaag taaaggagag 120960 tgccagagag ggcaaatgtg atgaaagcca caatcttttt ataaacctaa ttttgaaagt 121020 gacatacaag gctaggcatg gtggctcaaa cctgtaattc cagcactctg agaggccaag 121080 gagggtggac tgcttgagcc caggagttca agaccagcct gggtaacatg acaaaaccct 121140 gcctctacta aaaatacaaa aattagctgg tctggtggtg catgcctata gtcccagcta 121200 ctcaggaggc tgaggccaga gaattgcttg aacccaggag gcggaggtta cagtgagccg 121260 agatcacacc actccactcc agcctaggcc acagaatgaa accctgtcaa gaaagaaagg 121320 aaggaacaag ggagggaggg aggaaggaag ggaggtaggg aggcagggaa agaccgagaa 121380 agtgacatac catcattttt gctgtagttt gttcattaga agcaaaatca cttggtccag 121440 cccacactct ggggagatga ttttctaact ccatttgtaa taacttattc tacttttatt 121500 agttggcatt atacagtaag aaagagcttt cttttctctt cttatttatt catatatggc 121560 tcatgtgttt tttccaatga gttatattct attactaaca ttttttattt tgacctcaaa 121620 ttgttttaga tgttaccaat aagaacctct tcaagctggt tcttgtgtcc ttttgccata 121680 actctctcat tttcttgaac cctttcttac tttctgatat aagaaaatat tagagactca 121740 tactttcctt gttccagttc tgagatgaac catttatcca aaagccttgc ttcattttag 121800 tagggaatag tatttagaaa ctaagatctg ggtgtgaggt atgctcactg ctaatgggct 121860 gtcactgttt ctaggccttg tcagcagacg gagctaggaa aaacacacat aaacacaccc 121920 atatttatat ttgtacacac actccctcaa aatcgtgagt tcatattgat acctccagtt 121980 ctggttcttc ctagccttcc ccctttccat ctttgtattt ttattttcca acagtaagaa 122040 ccctggctcc cagtgctatg aatatattta ctcatttgct ccatccactg cactccagcc 122100 taggccacag aatgaaaccc tgtcaagaaa gaaaggaagg aatgagggag ggagggagag 122160 aggaagagag agaaggaaga aggaagggag ggagggaaaa ctgagaaagt aacataccat 122220 catttttgct gtagtttgtt cataagaagc aaaatcactt ggtccagccc acactctggg 122280 gagatgattt tctaactcca tttgtaataa tttattccac ttttattagt tggcattata 122340 cagtaagaaa gagctgctga agatttgctt gcaattggtt gtctttaaac tgagggtata 122400 ttgtcaaagt actgtgctga aaagttacct gtagtatagt tatgtgattc attaaaataa 122460 agtttgtttc tattatgtgc agttttagag ttttgccaca ctctggttga ttagtatatt 122520 ttctgttgct tttttgtttt gttttgtttt gttttgtttt tgagataggg tctcgctatg 122580 tcacccaggc tggagtccag tggtacaatc acagctcact gcagcctcaa cctcgtgcac 122640 ttaagcgatc ctcccacctc agcctcccaa atagctgggg ctgcaagtgc acaccaccat 122700 gactggctaa ttttttaatt atttatttat ttatttattt attttagaga tggggtctca 122760 ctatgtttcc ccaggctgac cctgaactcc tggggtcaag tgatcctcct gccttagcct 122820 ccaagtgctg gtattacagg cataagccac cacacctagc ctagtattct tttttgaata 122880 tgtaaaacat taacataaag tcaaaactat taaaaaaagg tgtactcaga aaattgtcat 122940 tcctccccta taccttctgc ctcattcaca ccacactctg tagataatcg atttcattag 123000 tttgtggttt atcctcactg tgtttctttt tgcaaaacgc aaaaacaaaa cctatacata 123060 tttatatttt cttatgtcct cttctttctt acacaaaagg taacacacta tgtaggtagt 123120 cctggctttg aacagtttca ctataaaaat atttgttact acagcttaaa taacataagt 123180 ctcctaaaaa taattcaaat tttagttacc atggtatatt aactttgagt agttccataa 123240 aggacaaact tggctgctag cccttcagtc cacagagcac tttgaaaata acagatgagc 123300 aaaataatgt ggccaatcac atgacttctt tcaaagtatg tcagtgatca gtcactgtgt 123360 gcctataatt tagttcatgc acagacagca aagcatgtag ttgtgttgcc ttccagtgat 123420 aaacccacat aacattttag aaaaatgtat taagaattgg ccagcaaaga taaaagtgca 123480 gcaaagaaac aaaagtgata atgttttcag tgaaatttga attgaacata aatggagtta 123540 tagaagaaat agctgaccat gggaatgttc acactgctac tttcaagaat ctctagaagg 123600 gcagctaaag gagcttagtg aaggtgaatt tattgacatg aatgagaaaa gtaattgtga 123660 tgaaaaggat gaagatgtcc cagagaaagt aatgccagca aaaacttcac attaaaggaa 123720 ctctcagata tttcaaagca ttgaaacctc caagaataaa taaaatgttg gaagttgatc 123780 caaacttaga aaggagtatg gcaacttgtc aagatgaaga aaaggtgctt attccttttt 123840 atttatttat ttagagacag agtttcactc ttgttgccca ggctggagtg caatggcatg 123900 atctcagctc accgcaacct ccacctcctg gattcaggca gttctcctgc ctcagcctcc 123960 caagtagctg agattacagg catgtgccac cacgcccggc taattttgta tttttagtag 124020 agacagggtt tctccatgtt ggtcaggctg gtctcgaacc cccaacctca ggtgatctgc 124080 ccacctcggc ctcccaaaac actgggatta caggcatgag ccaccatgct ccacctgctt 124140 attccatatt atatgttata ggatgaaaag aggccaaact aatcttgaca tgttttttac 124200 aaggaaataa tcctccatgg ttctaatttt tttttttttt tttttttttt tttttgagac 124260 agagtcgcgc tctgtcaccc aggctggagt gcagtggcac gatcttggct cactgctagc 124320 accgcctccc gggttcacgc cattctcctg cctcagcctc ccgagtagct gggactacag 124380 gcgccggcca ccacgcctgg ctaatttttt aaaaaatatt tttagtagag acggggtttc 124440 accgtgttag ccaggatggt ctcgatctcc tgacctcgtg atccgcccgc ctcggcctcc 124500 caaagtgctg ggattacagg cttgagccac tgcgcccggt gggtctaatg ttttaaatta 124560 cactgtgtta aataaatatt agtttgttgg tttttttttt agttttttta tttctctaca 124620 aatttacaac caataagagt ttttaatgct ttgacaaaaa atgttaaagg tcatagtaca 124680 atcgcatttc ttcccattga ttattaacat cactttacat agtttcatct tgcattagca 124740 attttgtgtg tgtgtttgtg gttttaagga gcggagagtt taataggcaa gaaggaaggg 124800 agaagacaga aggaaggagc tcccccttac agagacagag ggagcggggc tccaaaagag 124860 gaggtcccca tctaccgcgg ataccagcca ggtatatatg cagaggctgg tggaggtgat 124920 gtctgatttg catagggctc aggggattgg tttgaccagg catatcattc acgtagcccg 124980 agaaaaagct ggccctccca ccccagcctt ttaatatgca aacgtagggc gccatggatg 125040 ttctaaacac gtggagatat gtggggggca gccatgtggc caggaacttg tggggcaagg 125100 gcaagaaggc tgtgggaatc gccaagttga atggacctag tttctaatgg cctgcatttg 125160 catatcaaag gttgctggcc tggctcctag agccggggct ttaaaagaaa cttttccgga 125220 gatgctttaa aaaatgaaaa cttcccaagg accccttttc ctgtctatct gcataaaata 125280 atttctttta ttatttattt atttatttat ttatttattt atttatttat ttatttattt 125340 attttgagac ggagtctcgc tctgtcgccc aggctggagt gcagtggcgc gatctcagct 125400 cactgcaagc tccgcctctc gggttcatgc cattctcctg cctcagcctc ccgagtagct 125460 gggactacag gcgcccacca ccacgtccgg ctaatttttt gtattttcag tagagacggg 125520 atttcaccgt gttagccagg atggtctcca tctcctgacc tcctgatccg cccgcctcgg 125580 cctcctaaag tgctgggatt acagaataat ttcttaataa ctcctaccac attcctccct 125640 gtggcgatat caaactaact gctgttagga ggctttgggc gaccattgct tctggctact 125700 tcctgctgaa aaggggcgtc taatggagaa cagcagctag ggctcctcct ggggttgatc 125760 taagggtcct cggaagaatg gcgtccatgt gtggttcagt ttacagcacc gtttggagtt 125820 tgattgcttc taggcgagaa gaaacaattc aagttatagt attgagtata cagagtccaa 125880 atatcaatac aagacatata agcaagagag tgcttaataa aggggttaac caattccata 125940 aagaagactg gaagtaatta aagagggatt gtagccactc ggggctgaag cccacatttt 126000 ccctgagcct gtcaataatt ttgatttgat ttttaagtcc ctgtagattt gcctcttctt 126060 tactacaggt gttaatccca aagaagcatg tttcatttaa aaatgcatta ctggccaggc 126120 gtggtggctc gcgcctgtaa tcccagcact ttgggaggct gaggcgggag catcatgagg 126180 tcaggagttt gagaccagcc tggcctacat ggcaaaaccc catctctact aaaaatacaa 126240 aaaattagcc atcgtggtag tgggcgcctg taatcccagc taattgggag gctgaggcag 126300 gagaatcgct tgaacccggg aggcagaggt tgcagtgagc cgagatcgca ccactgcact 126360 ccagcctggg caacagagca aaactccatc tcaaaacaaa acaaacaaac aaacaaacaa 126420 aaactgcatt actaaatcca ataaaaagtc ctagtagact cagtgatagt aaaactttca 126480 tgcttccttt ttgccagtaa ctattatccc tgctataagg atactaatta agcaaaatac 126540 gacagcaatg gaaactctgt ccaatatttc agttagaagg tgctaccatg gataacccta 126600 ttgcaaatag tagagtgagg aaagcagttc ccacaaatgt ggtgtggtag gtaatttcca 126660 tctaaaattt tacttgccaa catatagaat tcccctctgt gggcctacga agttccttgg 126720 ttttattttc ccaaacaaag aaacctccgg gttacaggta ccttacttac tttcattacc 126780 tggcacaatt tgcaaaataa ttgcccagaa ctagcatatt gattcacatt ttcacattac 126840 ccatcccttt ttccccccca ccaagctgca gaagatcacc acttgattca caggaataag 126900 cagggccagg gttagtctaa aatgtaggca aaaagcttaa aaacaattaa tgagactagg 126960 gtttaatgac aaatgtatga taagctttgg agcaaaattt ttctctccag tcctcatttt 127020 tggtaaaaac taattatgaa tgaactttaa tcttatactt ggcctgatta tttgcatgaa 127080 gtgcagcaag aatggttatt tctacatagg acttttggat tggctttgat gaaacactgt 127140 tccacaagga atttcagatt agacttttaa agctgagccc agacatgggt ttgtatcctc 127200 taatacctgt gagttgggtt atcctctcct cttgaggtcc caagataaac tcagagcttc 127260 cagacctgtt agaaagtgac attcttcact gaccacaggt taggaaccct gtgtggggac 127320 tgtgtagaca aggtgtgagg ccagttctcc ccaaggggct tttattggct ctgcatgtca 127380 agcttgattc cttaaaggga aacacaccct ttcagttaaa gccttggcaa aataaccggt 127440 ttttccaatt gtgttctgtt gacaaagaaa aatggattct tgctgcactg atgcgaacaa 127500 ctatattgcc gtaagttaag agtacttaca gatagtctcc aaattttaga ggaaccaggc 127560 agagaaaaat gaacatgctc caaattttgt tcacagtagt ataccttact tgattattaa 127620 aggccataaa tagtttaaaa taagtttcct ttcccagtcc atgcaccaaa atgatacggc 127680 tctgatgagt ggaggaacaa cagggttcct ggtcctcatg ctggtttaga taaaatgaca 127740 cagacacatg tggagtggtt ttaaggagtg gagagtttaa taagcaagaa ggaagggaga 127800 agagagaagg aagacgctcc cccttgcaga gacggagcgg gggttccaaa gctgaaagag 127860 gaggtccccc acattaacaa tttttaaaat accgtacaac tgcagaaaat gaggactgcc 127920 tgtacatact gtttgacact ttgttttttt ttttaactta tcaactttat tttgtttgtt 127980 tgttttggtt ttgggttttt gtttgtttgt ttgttttgga gacgagtctc actctgtcag 128040 ccaggctgga gtgcagtggc acaatcccag ctcactgcaa cctccacctc tcgggttcaa 128100 gcaattctac tgcctcagcc tcccgagtag ctgggattac aggtattcgc caccacatcc 128160 agctattggt tttggttttt gagacagggt cttgctgtgt cacacaggct ggagtgcagt 128220 ggtgtgatct cagctcactg caacctctgc ctcccaggct caagtgatcc tcccacctca 128280 gccttccaag tagctgggac tacaggcatg cacaccatgc gcagctaatt ttttctattt 128340 tttgtggaga cggggtctca ctatgttgct taggttggtc acaaattcac agcctcaagc 128400 agtcctcctg cctcaccctc ccaaagtgct gggattacag gcatgagcca ccacatccag 128460 ccttaccagc tatattgaag tataatttat ataacataaa atttgccttt taaaattata 128520 cagtgcaatg cattttgaca attgtttaca tctgtgtaac caccatgcaa tcaaaatata 128580 gaacatttct ataaccttca aaagttccct catgcccctt tgcaatcaat tcactacttc 128640 tccagctcca ggcaacaact ggtctgcttc ctgtcactat aaattagtgt tgcctctttc 128700 agaatttcat ctaaatggaa tcctataaca tatactattt tgtatccatc ttcttttact 128760 ccaaagttct tgaaattcat tcatgttcct gtgtgtatca gcagcgtgtt ccatttgatt 128820 gttgagcagt attgcattgt gtggatatat cacaatgtgt tcattcattc aactgttggt 128880 ggacatttga gttgtgtcca gtttagtgct attctgaatt aaagtgatgt gaacaatcat 128940 gtacaagtat ttttgtaggc atattttttt tatttctctt ggataaatac cccaaaacag 129000 aattgttttg ggggtcatat gaaatgggaa gtatatgctt aactttataa gaagctgcca 129060 aactattttt caaaatggta atatcacttt acattttcat gagcaatgca taaagcgttc 129120 cgcttgctac attttctcac caatgcttcc tattgtcaat tttttaaatt ttagcaattc 129180 tagtgggtgt gtgatactat ctcattgaag tttcaactgt ttttccctgt tgactagaga 129240 cactgagcaa cttttcatgt gttgtctatt tgtatatctt cttgaagcat tcgttcatct 129300 ttaactgagc tgaacgcctt cttaaaattg agctatggga gttttaaaat atatccttgt 129360 agctgggcgt gatggcaggt gcctgtaatc ccagctactc aggaggctga gacaggagaa 129420 tcgcttgaac ccaggaggcg gaggttgcag tgagccgaga ctgcaccact gcactccagc 129480 ctgggcaaca gagtgagact tcatctaaaa aataataatt atacatgtaa ttatatatga 129540 tttttatata tgtaatatat atattcttga tgtgagctct ttgtcacata catattttgt 129600 ggatatttta tcccagacta tgacttgtct tttcattttc ttagttgtgt cttttgaaga 129660 gcagaagatg taattttgat aaagcccaat ttattttttc ttttatagtt tgtatttctt 129720 atgtcctatt caaaaactcc ttgcctactg aaaacttatg atgattttct cctatatttt 129780 cttttagaag ttttatagtt ttaccattta taatttggtc tatgaatcct tttgagttga 129840 tgtttatgta tggtgtatgg tgtgaggtaa caatgaagat tcatattttt ttccaaagga 129900 atatccaatt gtctctttgg aaaaatatgc tgagaaggct atcttttccc caccaaataa 129960 tcttagcacc ttaatcaaaa atcatttggc catggacata tgtaggtgtg ggttttttct 130020 gggctctctg tgttagatgg atagatagac agatacagat atataactgt gtttacacat 130080 atgtaactgt aaacacagtt atatatctat atatccacca acagttgaat gagaataaac 130140 tattgttata agcatatata cacattgtat atatatgtgt acatatacat attgcatatg 130200 tatgtataca tatatacaca caaagtatat atatgtatgt atacatatat acacacttaa 130260 agtaatggcc tccagttcga tccaagttgc tgcaaaggac attatttcat gccttttcgt 130320 ggctgagtaa tattccatgg tgtatatata tatatgtgtg tgtgtatata tatgtattat 130380 gtatatatat atgtgtgtgt gtgtgtgtgt gtgtatatat atatatgtgt atatatatat 130440 accacatttt ctttatccac tcattagtcg atggggactt aggttggttt cacatttttg 130500 caattgtgaa ttgtgctgct ataaacatat gtgtccaagt gtctttttca tataattact 130560 tattttcctt tgggtagata cccaatagtg ggattgctgg attgaatggt agatctgttt 130620 tttgctcttt agagaatctc catactgttt tccatagagg ttgtactaat ttatattccc 130680 agcagcaatg tgtaagtgtt ctcttttccc cacatccaca ccaacatcta ttgttttttg 130740 actttttaat aatggccatt cttgcaggac caaggtggta gctcgttgtg gttttaattt 130800 gcattttcct gatgattagc gatgttgagc attttttcat atgtttgtgg gccatttgta 130860 taccttcttt tgagaaatgg ctatttgtgt cctttgccta ctttttaatg ggattgtgtt 130920 ttatttttct tggtgatttg ttagttcctt gtagattctg gatactagtc ctttgtcaga 130980 tgtgtacttt gcaaagataa tattttggat gttatatttc cattataatt tagttcaaag 131040 tattttctaa tacaccttgc aatttcttct ttgacccatg gattatttta aagtttgtta 131100 ttttgtttgt ttattttgag acagagtttc actttttttg cccaggctgg agtgcagtgg 131160 cacaatcccg gctcccagat tcaagcgatt ctcctgcctc agcctcccaa gtagctggga 131220 ttacaggtgc ccaccaccac acccagctaa tttttttttc tttttttttt gagacagagt 131280 tttgctcttg ttgcccaggc tggagtgcaa tggcacgatc tcggctcact gcaacctctg 131340 cctcctgggt tccagcaatt ctcctgcctc aacctcctga gtagctggga ttccaggcat 131400 atgccaccac gccaggctaa ttttgtattt ttaatagaga cggggtttct tcatgttggt 131460 caggcgggtc ttgaactccc gacctcaggt gatctgcccg ccttggcctc ccaaaatgct 131520 gggattacag gcatgagcca ctgcacccag tccaattttt tgtattttta gtagagatgg 131580 ggtttcatca tgttggccag gctggtcttg aactcctgac ctcaggtgat ccgcctgcct 131640 cggcctccca aagtgcaggg attacaggta tgagccacca tgaccagcct aaagtgtatt 131700 gtttagtcac caaatatgta agtattaccc aaatatattt gtcactgatt tctaatttaa 131760 ttgtattgtg atccaaaaat atacattgta tagtttctat tcttttaaat tcgttaacat 131820 ttcttttatg gcacagaata tggtctatct tggtgagtgt tgcttacaca caactgtgta 131880 actgaaaact gtgtattctg cttctcgtgg ttgttgtatc ctataattgt caactagatc 131940 aagttagtaa gagtgttgtt cagtgatctt ttcttcttca gtgtttactg tatttgctaa 132000 tcccatccag tgaagtttcc atttcatata ttgtattttt cacttttaga agttccattt 132060 gactctttca tttccatcct caattatctt catatttttc tttaaatttt tgagcacatt 132120 tataatggag gttttaaagt ccttgtctgc taattttgtc acctctgtaa ttcctatgat 132180 gattttcttc ctggcttggg gtcataattt gttgcttatt tgcatgtcta ataatgtttt 132240 tattggacag cagacattgt aaatgttata tttttgagtg tttggatttt gtctttcttt 132300 aagaactatt gcagtttgtt ttggaaggct attatgtttt ttgcagatca ggttgatctt 132360 ttcaaggctt gtttttaagc tttgttagga caggtctgta gtaacttttg ccttgggcta 132420 atttagacct accacttaat tctgactttt ttgattaatc tgagtgttca gcagggtctc 132480 tttattatgg ctaaatgaaa ttcaaacatt ttccagccct atgtgaccat caagaattca 132540 gctaatagct ccctggcagt tcttcgccca gctgcagaaa agtgtcagtg cactctatgt 132600 atgctcagat tattatttag ccaaagactt ggggatccat attaatattc ctggagttct 132660 ttgtgtagct ccattctctt tagtactcta tcccataaat tctggctgcc tcaatctcct 132720 aatctcccca aactctaata tctattcctc aactcagcaa aaccatggtg ttattcttgg 132780 atttcccctt tcctgcccca cagtctgaaa gttgtctcca ggcaaaaaaa atggagatcc 132840 tagtttgcgg atcctcattt ccttctcctt tttttttttt tttttttttt ttttttgaga 132900 tggagtctcg ctctgtcacc caggctggag tgacgtggcg tgatctcggc ttactagaaa 132960 ctccggctcc cgggttcatg ccattctcct gcctcagcct cccgagtagc tgggactaca 133020 ggtgcctgcc accatgcccg gctaattttt tgtattttgt ttagtagaga cggggtttca 133080 ccgtgttagc caggatggtc tggatgacct cgtgatctgc tcacctcggc ctccaaaagt 133140 gctgggatta caggcatgag ccaccgcgcc cggcctgctt ctcttctctt atgggttaga 133200 atcctgcact gtcttttgaa caaatgtcta aaagctttta tcacacattt tgatccactt 133260 cccagttgtt atagtggtat atctggtttc acatgactga aaggaaaagt tttcaccttg 133320 ctttttgtac taataatata tcctggaaat cattctatat aaatttatag aaatcttcat 133380 ttttaaaata gcttcataaa actccattgt aaaaaccagg tgcagtggct catgcttgta 133440 atcccacact ttgggaggcc aaggcgggtg gatcacctga ggtcaggagt tcaaggccag 133500 cctggccaac atggtgaaac tccgtctcta ctaaaaatac aaaaattagc tgggtgtggt 133560 ggtgggcgcc tgtagtccca gctacttgga aggctgaggc aggagaattg cttgatttca 133620 ggaggcggag attgcagtga gctgagattg cgccactgca ctccagcctg ggctacagag 133680 cgagactccg tctaaaaaaa aaaaaaagca aaaaaaaaaa ctccattgta tgtgcacata 133740 tcattatctg ttcaacccat ctatgacttg tcatttaggt agtttccatc caatattttt 133800 gcaatataaa aaatgctaat gaagaacctg agatatatat atatctatat atatagatat 133860 atatgtttgt tgttgttgtt gttatttttg aagtatgtac gtataataaa ttcctaatag 133920 tgtgattgct gcatcataag gtaaaggcat atgtagtttt gttaaatata gctattcccc 133980 atcttgcatt cctacaaata gatgagaatg tccattgtcc catagtctcc tttgcagagt 134040 atattgtcaa gctttttaat tgttgccaac ctgatgggta aaaagatatc tccaaataat 134100 tttaattaaa atttctctta ttatgaatga ggttaaatag tttttcatat gtttaaaagc 134160 cagtttatat ctttttgttt ttttagagac aggaatcttg ttctgttgcc caggccaaat 134220 tgcagtgatg cagtcatagc tcactgtagc ctcgcactcc tgggctcaag caatcctcct 134280 accttagcct cccaagtagc taggactaca gatggatgcc accatgtcca gctaattttt 134340 ttattttttt gtagagatgt gaggtctcac tatgttgccc aggcttgtct tgaactactg 134400 gcttcaagtg atcctcccac ctcagcctcc caaagtgcta agattacagc catgaaccac 134460 cacaaatgac cctatatatt tttttgaatt gtctgttcat gtcttatttt catttttcta 134520 gtagtttttt ttttaagtgt tttagcctaa atttgtaaaa agtttagggg atatatgaag 134580 ggactctaaa tgtttatgaa gaaatttaat taaaagataa aaataaaaat ataagcttta 134640 tttttcaaca tgagctccat caagttcaag gcacttttgt aagcaatgat actagccatt 134700 tagttcaccc ctaaagaact gagagtcctg ggaatttagc catgtcaatg cagtattttt 134760 tatattggtt actgaagaaa aaatgggtgc cctttaaagt tgtaagatta ggaacaaaaa 134820 caagtcagaa gaagccaaat cagcactgaa aggtgggcac ttaatgatta cccaagaaaa 134880 ctctcaccaa attgcccttg cttcatgaga ggaatgagcg ggagcattgt cgtggtcagg 134940 aaggattctg gggaagtttt cccaggcatt ttttctgctg aagctttggt aactttctca 135000 aaacactctc ataataatca gatcttatca ctctttggcc ctccaggaag tcaaccagca 135060 aaatgctttg aacatcccaa aaaagcgctt gccatgacat ttgctcttga ccagtctgct 135120 tttgcattgg tcaaatgcca ccacttccac ctcttgtgct ttgttttcag gatcagactg 135180 gtaaagtcat gtttcatctc ttgttacagt tttttttttt ttaagaaacc cttcaggatc 135240 ttgatcacat ttgtttaaaa tttcaactga ggctgggccc agtggctcat gcctgtaatc 135300 ccagcacttt gggaggccga ggcgggcaaa tcacgaggtc aggatttcga gtccatcctg 135360 gctaacatgg tgaaacccca tctctactaa aaatacaaaa aattagccgg gcatggtggc 135420 aggcacctgt agtcccagct actcgggagg gtgaggcagg agaacggcat gaacccagga 135480 gacggagctt gcagtgagct gatatcatgc cactgcactc cagcctgggc aacagagtga 135540 gactccagct caaaaaaaaa atcaagtgaa aactctggtc ttaaactgca gctgatctat 135600 tttattttta ttttttttca gacacagcct tgctctgtta cccaggctgg agtgcagtgg 135660 caccatcatg gctcaatgca gccttggcct cgtgagctca agcaatcttc ccacctcagg 135720 ctcccaagta gctgggacta caggcacatg ctaccatgcc tggataattt ttttgcagct 135780 aatctagatg taatggtttt ggcacccatc taatggaaag tttgctcaac tttaattttt 135840 cagtcagaat tgtgtaagct gaaccgagat gtctatggtg ttggctattg tttctgctgt 135900 taattgtagg tcttctttaa ttagagcaca gacaagatca ttttttttcc tcccaaattg 135960 atgtagatgg tcttttgctg tgggcttcat cttcaacatt gtctcatccc ttcttaaaac 136020 aagctagcta cttgtaaact gccgttttct ttggagcatt gtctccataa acttttcaca 136080 aaacatcagt gatttcaccg ttcttccact caagcttcat cataaatttg atgtctgttc 136140 ttgtttccat tttagcagaa ttcatgttac tctgataggg gctcttttca aactgttatc 136200 ttattcttct tagtgcctca aactagatcc tattcagaca tggtataaca agttagtatg 136260 ggtttatttt ggtgcaagaa atattttgaa atccacacat ttttttcata atatgcattt 136320 tccatgaagt ttttgaaaac tccttgtatt aggaatatta gtcctttgtc cagtaaacag 136380 actgcaaata ttttctcaca gctcatcatt taccttttgg catttttttg caatgcaatt 136440 tttttccctt tgtttttgtt ttttgtgtaa tgaatcaatg ttttcttttt tttttttttt 136500 tagaccaagt ctcactctgt cacacaggct ggagtacaat ggtgcaatct cagctcactg 136560 caacctctgc ctcccaggtt caagtgattc tcatctctca gcctcccaag tagctgggat 136620 tacaggcaca tgccaccatg cctggctaat ttttgtattt ttagtagaga tggggtttca 136680 ccatgttggc caggctggtc tcgaactctt gacctcaagt gatccactca cctcggcctc 136740 ccacagtgct gggattagag acgtaagcca ctgcccccgg ccaaatcaac gttttcttat 136800 attgcattta ggttttaagt catagttaga aagcctttcc ccacacctag gttatagaaa 136860 cattcattac ttttttcttc cagtgctagt acttgcatgg tttttggttt ccacatttag 136920 atccctgatc taattggagt ttattctttt gtgtgctgag atatggatct gattatatct 136980 tttttcccaa atggctatcc agttgtccca atgccattta ttaagcactt catctttgtc 137040 ccagtgattt gagatagcat ctttatcatg taccaaactt ctatagtgcc agaagatttt 137100 tatttttttt agacagggtc tggctctgtt gcccaggctg gagtgtagtg gcacaatccc 137160 agctcgctgc aacctccgcc tcacatgctc aagtgcccgc acctcagcct ctcaagtagc 137220 tgggactaca ggcacatgcc accacaccag gctgattttt atattttttt gtagaatgag 137280 atttcaccat gttgcccagg ctggtctcaa actcctgagc tcaagaaatc cgcccacctc 137340 agcctcccaa aatgctagga ttacaagcat gagccaccac acccggctgc cagaaaattt 137400 taatgatcag aaaaccacaa ttctttcttc ctctgttata tgttgaagta aaatacttca 137460 tttagaaaac taagccgggc acagtggctc acacctgtaa tcccagcact ttgggaggtt 137520 gaggcaggca gatcacctga ggttaggagt ttgagaccag cctggccaac atggtgaaac 137580 cctgtctctg ctaaaaatag aaaaatttgc tgggcatggt ggcgggtgcc tgtaattcca 137640 gctacttggg aggatgaggt aggagaattg cctgaacctg ggaggcagag gttgtggtga 137700 gccgagacca cgccattgca ccccagcctg ggcaacaaga gcaacggtaa actccatctc 137760 aaaaaaaaaa aaaaaaaaag aaagaaaaaa gaaataactc agccatacaa ggctacccat 137820 ttggtgagaa ctaataataa gttagatagc aaggtaatag caaaatgtgg gtgcaaaatt 137880 aaagcaagtt atttctgagg agaatgtagg tctcatggaa gattttcatg tggacaaatt 137940 tagtaaattt tttgcaggta gtttcctgac atatttaaca tttgtgatat agtaaacaat 138000 aagaaggtac taaaggctgg gcgcggtggc tcacgcctgt aatcccagca ctttgggagg 138060 ccgaggtggg cggatcacaa ggtcaggaga tcaagaccat cctggctaac acggtgaaac 138120 cccgtctcta ctaaaaatat aaaaagttag ctgggcgtgg tggcgggtgc ctgtagtccc 138180 agctactcgg gaggctgagg caggagaatg gcgtgaaccc gggaggcgga acttgcagtg 138240 agccaagatc aagccactgc actccagcct gggcaacaga gcgagactcc atctcaaaaa 138300 taataataat aataataagg tactaatatg atccagacta gaagagaata gcactaaaat 138360 gggagatggg gtaaacctgt ggtttttttt accttaggct tttgacttcc aaaattattg 138420 tttttgctgg gtgcggtggg tcactcctgt aatcccagca ctttgggagg ccaaggtggg 138480 aggattgctt gagcctagga gtttgagacc attctaggca acaaagcaag aacctgtctc 138540 taaaaaaatt taaaaattag ccagaaatgg tggcacatgt ctgtagtccc agctacttgg 138600 gaggctgagg caagaggatt gcttgagcct tttgaagttg aggcttcagt gagccatgat 138660 caccccactg cactccagct tgggcaacag agcaagaccc catctcaaaa aataaaacaa 138720 aatagactgg gcacgatggc tcacgcctgt aatcccacca ctttgggagg ctgaggtgga 138780 tggatcatga ggtaaagaga tcgagaccat cctggccaac atggtgaaac cccgtttcta 138840 ctaaaaatat aaaacttagc tgggcgtggt ggtgcacacc tgtagtctca gctactcggg 138900 aggctgaggc aggagaatcg cttgaacccg ggaggtggag gttgcagtga gccaagattg 138960 tgccactgca ctccagcctg gcgacagagt gagactctgt ctctaaataa ataaataaat 139020 aaaacaaaat aagtaaaata aaataaatgt ttgtagttcc aaaatatttt gatgacataa 139080 tttcttcttg ttctaataaa actacatatg cattggtcct atgacctagt aatcacacta 139140 ttaggaattt atcataaata cacacctcaa aaattacaaa aatacatata taccagctta 139200 tttattacag cgttatttgt aattgcaaaa acattgtaga tagaatggag gtcacataaa 139260 acttattctt aagattcaga ccgggtgcaa tggctcacgc ctgtaatctc ggcactttgg 139320 gaagccgagg caggcagacc acccgaggtc aggagtttga gaccagcctg gccagcatgg 139380 tgaaacccca tctgtaccaa aaatacaaaa attagctggt cgtcgtggca cgcctgtaat 139440 cccagctact cgggatgctg aggcgcgaga actgtttgaa ccccggaggc agagactgta 139500 gtgatctgag atcatgccac tacattccag tctgagcaac agagcaagac ttcgtctcaa 139560 aaaaaaagat catagatcat cttatcaaat caaagtatgc aaaatattca agtaaacttc 139620 agataaatat gaaggctaaa ccattcagct tcttcaccaa acccttgaat gtcccacctg 139680 tctaaatgga gatacatgtt tgtttgattt attggttaac tgtttttatt ccatttttcc 139740 tcaaatgatc ccataatttg accttaggaa gctgttcaaa tagacacatt aggttgaatg 139800 gaaagactac tcgatgatat ttaggatttt aagaggattt tatgtatttt ttccttgtgt 139860 gcaataattt aatagcatct tgaataggat tttctgatat tactaaccct ctgggaataa 139920 tattaggtaa ttagacagtt agctaatatt aaaatatgta tcaggtaata tttattgaga 139980 gtttcctctg tgccaagcag gatcaacttc ataggcaggc gacctgtgcg gggacacagg 140040 gcttcatgct tagataggcc cccttgcttt gaaggcccct accctttggt tagggctctg 140100 ctgttaccat cttgaaattc ttaataattt ttattttatt tttttgagtc agggtcttgc 140160 tctgtcgccc tggctggagt gcagtggact cactacagtc ttgaattcct gggctcaagc 140220 aatcctccca cttcagcctt ctgagtagtt aggacgacaa acacacgcca ccatgctcag 140280 ataagttttt tgtttgtttg tttttttgtt tttgtttttg ttttttgtag agatgggact 140340 gtccctatgt tgctcaggct ggtctcaaat tcctggcctc aagtgatcct cccacctcag 140400 cctcccaaag tgctgggact acaggcatga gccactgtgc ctggtcaatc atttttatta 140460 acaagcccaa gccctctttt tttttttttt ttttttgaga cagggtctcc ctctgttgtc 140520 caggctagag tgcagtggtg cgatcttacc ttcactgcaa cctctgcctc ctgggttcaa 140580 gtgattctcc tggctcagcc tccctagtag ctggaattac aggcacccac ccccatgcct 140640 ggcaattttt ttgtattttt agtagagatg gggtttcacc atgttggcaa ggctggtctc 140700 aaactcctga cctcaagtga tccacccaac tcggcctccc aaagtgctgg gattacaggt 140760 atgatccact gcgcccggcc tccaagcccc ctatttttat tttgcactga ccctacaagt 140820 tacgtagcta ggcttagtta tgtttttagc aaggaaagtg tataatctca tgtacctttt 140880 gaaagattac tcaggtctct gcatgtgaaa tggaatttag ggaatgcaag agagggagta 140940 aaaataacag cgaggaagct atgatagcat ttaaggttgc tttgactcag gggtagcagt 141000 agatagggta agtaattgat agtttcaaaa tatattttgg gagtagtaag cattggtatg 141060 gattagtaat atactggatg tggggatgca gaaaaaaata ttaaaaatta cttctgaaat 141120 tctggctgga atagaagtgc cacttaccag gtaaggaagg ttggagacat aacatatttg 141180 agggtgtggt caaaagatga gtttgacatt atgctatgtc atataaaaga catataaaag 141240 actacctatt ttataattcc tttttaataa aatattcaga aaaagcaaaa ctgtggttgc 141300 ctgaggctga agctaggaag attgactaca gacaagcatg agggaaattt tgggggtgat 141360 gagagttttc taaaactgga ttgtggggtt ggttgcatta ctgtataaat ttattaaaaa 141420 tccctgcatc gtataggggc actatattgt atgtagaaag ctgtgaaaag attttaaaaa 141480 tgattgacat gtctgtggtt atatcaatga gtactattat tattcccatt ttatacataa 141540 agaaaataaa agagaagtta aaaataaaag tttcatggtt acatagctac taggtgtaat 141600 atccagtatt ggaatttgaa tctttttgac actaagacct tactctcgat catataatac 141660 attcactttc tattttaaag ttatattata gccgggcaca gtggctcaca cctgtaatcc 141720 cagcactttg ggaagccgag gcaggcagat cacgaggttg ggagatcgag accatcctgg 141780 ctaacacggt gaaaccccgt ctccactaaa aatagaaaaa attagccagg cgtggtggca 141840 cgcacctgta tcccagctac tagggaggct gaggcaggag aatcgcttga acccagaagg 141900 cagagcttgc agtgagacga gatcgtgcca ctgcactcca gcctgggtga cagagtgaga 141960 caccatctca agaaaaaaaa aattatatta taaatgctgc atctcattgg tcagaagctc 142020 tcttgaaatt ataaaacaaa gaagaaaaaa gataaagact gggaaattgt gttgaatcag 142080 tatataaatc ctgtatactg gtccttccat ttcccctaga aataagtgat acaggccagg 142140 cgctgtggct cacacctgta atcccagcac tttgggaggc ggaggctggc agatcacctg 142200 aggttgggag ttcaagatca gcctgaccaa catggagaaa cccccgtctc tactaaaaat 142260 agaaaattag ctgggcatgg tggcacatgc ctgtattccc agctactcgg gaggctgagg 142320 caggagaatt gcttgaaccc aagaggagga ggttgtggtg agccaagatt atgccattgc 142380 actccagcct ggggaacaag agtgaaactc aaaaaaaaaa aaaaaaagaa agaaaaagaa 142440 aaagaaagaa ggaaggaagg aaggaaagaa agaaagaagt gatacaacaa gttacagcat 142500 ctttgtttat tatccactgt gagttgtatt accacacttt acttggctct ttggcaaact 142560 atattatctc ttcagatcac tagggctagg aaggcccact ggtaacttga aggagtaaat 142620 gtatcttcta aaaaatgctt acttccaggg agattggatc cacacaagtg aatacatata 142680 tagtccttag tgtatgctat gattatttta ctatgtcagt agcataaaga ttgctatatt 142740 aataagcatt aagtgcctgc tgtgctagac agtgaggatg caagtggcca ccaaaatagc 142800 atggtccctg ccctcctgga gcttcttttt ttcttcttca gtgggggaag cagatacttt 142860 gcttatgcaa aaataattat aaaatttaaa gttgtgccaa gttcaatgga aaaaatataa 142920 ggtgttctga gagagcataa caaaggatcc tggttttaac tggggcctaa tggaagacct 142980 ctattaggaa ataacattta aactaagacc agacagacct gtagaaatta gcaaagcaaa 143040 gggagggagg aaaaagcagc tttcctggca aaggaacaat ttgtgtgaag gccctgagac 143100 agggaagggc tggggttctg accaccctcc aagtggtgca atggaatata gtgagagagg 143160 gagaagacat gagaacttgg atactatgca aaggatttgg tattttaatt caagagcagt 143220 atgatgctac tgaggagcag ctggacaatt gtgtgatcca attaaaattt taggaagatg 143280 aacctcgcta ttgtggagaa tgcatacaca agggttctgt tggttcatga agaggtctta 143340 agaaaactat gagctgggtg cagtagctca ggcctgtagt cccatctact tagaagtctg 143400 aggcgggagg atcccttgag cccaaggagc tggaagttac agtgagctat gattattcca 143460 ctgtactcca gcctggatga cagagcgaga tcctgcctca gaaacaaaaa ccaaaaaaca 143520 aacaacaaca aaaacaacaa caacgaaaat ctcagaaaac tacaggcctt attatcaaga 143580 aaatgacagg ccttattatt gagaaaacta cttacatttt taaaagctga ttttcaaaaa 143640 ccagattgtg aattaagtga tgctgaatag gggaaaaaaa gactgataaa ccagtgtatc 143700 tctgaataac ccactagatc agtgcttgtc aaactttaat gtgttttcaa atcaccctga 143760 tgttttgtta aaatgtaagt catgtctcag taggtctaga ggagggcatt tctgcatttc 143820 taacaagctc cccggtgatg cctagaccat tggtcctcac actttgagta gcaagtgatt 143880 gggctatact ctttattcta aattctaaat gtattctatc ttctaatgcc tatcagccct 143940 cttgctggtc tggctaatta tcaaacttga gcatttaaaa ctgggggttt tcagagatta 144000 attgaagtgt taaagacatg gaaatatagg tcacatatgg cttttcatct cttccggaaa 144060 tatcctatat atccttactt cttttctacc tacctaacct atgtgcctac cccttcactt 144120 atgttcaagg ttctattata cttcaaaagg actctatgca atcaaagtga tgtccaagac 144180 aaatatacag aaatagtatg aggctctaac actttacatc taatggagtg gtttgcatca 144240 ttaattgagg cttactctgt gccaggcact ttacctgcct tcttcattta ataggatagg 144300 agcaggaact cttagaggtt catttcttgt tcaaggatat acatctcatc tctggcttat 144360 atcacagtgg actcttttat tcactatcct aatcattata attttgtttg gtgacaacaa 144420 ttctaaatgc agaaaagtta aggctcttta ttctgtgact aaaggctttg tattttctaa 144480 agatttgtgg agctttgctg ccattatttc aataatttta taaagatcct aggtggtaaa 144540 taggcctggc tttttttctt tttgaaatct tctccgtctt cttcttcatt agcagtgcaa 144600 cttcttgtgg catatggtac ccaagatctt gggaaaagga ttgatcaagt aaagggaaac 144660 gatagagaga gtgtgctcta caactgagat catgctcctt gtgaaagaca gggtagggaa 144720 atttcttatt gctccctggt tcttaagaaa tgagagctaa caatgacatc cagttttaaa 144780 agaaataaaa tctgaattgt acttttaaat tttataagcc agagttaaac caatagattg 144840 taactcctgc taatttgata gtagctccag ataatgagga agtgacaggg aatgctaatt 144900 tcatttggta agagataaaa ctgaaattat taatgtctcc acggaaatgc taaatgcctc 144960 cttacaagta gggtccggct aattgtctgt cttccaacaa gccagatttg ttggtgtttt 145020 tccagacaat gttgtgtagt tttcggtttg gttcgatccc ctttcttgtg atcaaagaaa 145080 gtgattcaaa tgtttaatga gtcttgattt ggattggaga cttgcagaac ggctagcctc 145140 acagccccaa ggctggcttt ccctaaggta ggtttcctat gcaccgatac tggcaaggcg 145200 ctttggctgg aaactctgga aggaagccaa aggaaagtga agttcctggc gctagcgcgt 145260 gtcctgctca gagagcccgg cgctagctca ttcttcgtgc agttattggc tgggactctg 145320 tgtgccgctg tcggccaatg aagacgctgg agatcgggcc cctgcccgtc ccctttctgc 145380 gccccgggat gaggcagaga ctgaacagcc ggcgagcaaa tcaacggcat ccagaaagcc 145440 atgtcggact cggcgcccag cgcccaagcg ctaacccgct gaaagtttct cagcgaaatc 145500 tcagggacga tctggacccc gctgagagga actgcttttg agtgagatgg tcccagaggc 145560 ctggaggagc ggactggtaa gcaccgggag ggtagtggga gttttgcttc tgcttggtgc 145620 cttgaacaag gcttccacgg tcattcacta tgagatcccg gaggaaagag agaagggttt 145680 cgctgtgggc aacgtggtcg cgaaccttgg tttggatctc ggtagcctct cagcccgcag 145740 gttccgggtg gtgtctggag ctagccgaag attctttgag gtgaaccggg agaccggaga 145800 gatgtttgtg aacgaccgtc tggatcgaga ggagctgtgt gggacactgc cctcttgcac 145860 tgtaactctg gagttggtag tggagaaccc gctggagctg ttcagcgtgg aagtggtgat 145920 ccaggacatc aacgacaaca atcctgcttt ccctacccag gaaatgaaat tggagattag 145980 cgaggccgtg gctccgggga cgcgctttcc gctcgagagc gcgcacgatc ccgatgtggg 146040 aagcaactct ttacaaacct atgagctgag ccgaaatgaa tactttgcgc ttcgcgtgca 146100 gacgcgggag gacagcacca agtacgcgga gctggtgttg gagcgcgccc tggaccgaga 146160 acgggagcct agtctccagt tagtgctgac ggcgttggac ggagggaccc cagctctctc 146220 cgccagcctg cctattcaca tcaaggtgct ggacgcgaat gacaatgcgc ctgtcttcaa 146280 ccagtccttg taccgggcgc gcgtcctgga ggatgcaccc tccggcacgc gcgtggtaca 146340 agtccttgca acggatctgg atgaaggccc caacggtgaa attatttact ccttcggcag 146400 ccacaaccgc gccggcgtgc ggcaactatt cgccttagac cttgtaaccg ggatgctgac 146460 aatcaagggt cggctggact tcgaggacac caaactccat gagatttaca tccaggccaa 146520 agacaagggc gccaatcccg aaggagcaca ttgcaaagtg ttggtggagg ttgtggatgt 146580 gaatgacaac gccccggaga tcacagtcac ctccgtgtac agcccagtac ccgaggatgc 146640 ccctctgggg actgtcatcg ctttgctcag tgtgactgac ctggatgctg gcgagaacgg 146700 gctggtgacc tgcgaagttc caccgggtct ccctttcagc cttacttctt ccctcaagaa 146760 ttacttcact ttgaaaacca gtgcagacct ggatcgggag actgtgccag aatacaacct 146820 cagcatcacc gcccgagacg ccggaacccc ttccctctca gcccttacaa tagtgcgtgt 146880 tcaagtgtcc gacatcaatg acaaccctcc acaatcttct caatcttcct acgacgttta 146940 cattgaagaa aacaacctcc ccggggctcc aatactaaac ctaagtgtct gggaccccga 147000 cgccccgcag aatgctcggc tttctttctt tctcttggag caaggagctg aaaccgggct 147060 agtgggtcgc tatttcacaa taaatcgtga caatggcata gtgtcatcct tagtgcccct 147120 agactatgag gatcggcggg aatttgaatt aacagctcat atcagcgatg ggggcacccc 147180 ggtcctagcc accaacatca gcgtgaacat atttgtcact gatcgcaatg acaatgcccc 147240 ccaggtccta tatcctcggc caggtgggag ctcggtggag atgctgcctc gaggtacctc 147300 agctggccac ctagtgtcac gggtggtagg ctgggacgcg gatgcagggc acaatgcctg 147360 gctctcctac agtctcttgg gatcccctaa ccagagcctt tttgccatag ggctgcacac 147420 tggtcaaatc agtactgccc gtccagtcca agacacagat tcacccaggc agactctcac 147480 ggtcttgatc aaagacaatg gggagccttc gctctccacc actgctaccc tcactgtgtc 147540 agtaaccgag gactctcctg aagcccgagc cgagttcccc tctggctctg ccccccggga 147600 gcagaaaaaa aatctcacct tttatctact tctttctcta atcctggttt ctgtggggtt 147660 tgtggtcaca gtgttcggag taatcatatt caaagtttac aagtggaagc agtctagaga 147720 cctataccga gccccggtga gctcactgta ccgaacacca gggccctcct tgcacgcgga 147780 cgccgtgcgg ggaggcctga tgtcgccgca cctttaccat caggtgtatc tcaccacgga 147840 ctcccgccgc agcgacccgc tgctgaagaa acctggtgca gccagtccac tggccagccg 147900 ccagaacacg ctgcggagct gtgatccggt gttctatagg caggtgttgg gtgcagagag 147960 cgcccctccc ggacaggtaa ggtttagcaa gtcatgcttg accctgttag tgctttttta 148020 ttcctacatc atattgagga aggaatggag ctgttttttt agtgatgaag atgttttcct 148080 ggtgatgcat tcacactttc aactggccct tcctagatca aagttagtgc ctttgtgaga 148140 tggtggcctg ccagagtgtg gtttgtggtc ccatttcagg gggaagatac ttgactcatc 148200 tgtggaccta attcacatcc tcagcactct tttgctatca caactaacca atcttgctaa 148260 gggatggtta agctaaaaca caagatctca gcgatcagag tttagcttgg tatcatttac 148320 attaggaata agctgctgga tacctctaac cagtggcagc ttctaggaat acaaaaacta 148380 cctcattcct ccacctttca agtgattgtg acatttgtat taaaactaat agctttttga 148440 taattttcct ttgtttatac agatcgtgta cctcattctc agataatttt ttatgaatga 148500 aatgaaattc caggcatcct ttaaatttta tttcaagcat tctactggaa atgatgtgca 148560 ccctgcttac aaaatatttt taccttataa cagtaatgca tgtttgctag aaaattcaga 148620 aaatacagaa aagtatttaa aaaattaaaa ctataatctc caaacccaaa gataaccatt 148680 tttaattata aaagtaataa tttatttcaa aaataaatct aggcaaccca agaaaacata 148740 aagtagccag actcagtggt gtgcacctgt agttcttgct gctcagtgcc tgaggtggga 148800 ggattgcttg agcccaggag ttctgggctg tggtgcacta tgctgatcaa ttgatcaatc 148860 cactgtctgc actaagttca gcatgaatac agtgacctct tgggagggca ggaccatcag 148920 gttgcctaaa gaggggtgaa ctggcccagg ttggaagtgg agaaggtcaa aactgctgtg 148980 ctatccagta gtgggatgac atctgtgaat agccactgca ctccagccta ggcaatatag 149040 ggaaaccatg tctctttaac aataacaaca acaacaacaa caatcccaga aactacaaaa 149100 ggagagtctt tttggtgcct ccagtgttag tccctgtcct tccagcctta tttttcttaa 149160 gtatatgcac aatgtgaaag gtagataaat tcatatcctt agacaggtaa agcattcatt 149220 aattcagggt ggtatgcaag gatactatcc aaggcatggt atccatgcaa ggtgactgca 149280 aggcctttgc cctggagaga accctataca tactctcaac tgtaggagaa acactgttat 149340 tttgttactc agtgcatcat tgctatcaac tcttggattt ggcagttagt caaatgaggt 149400 tctaccattt accaactagg agtctgtggc caagttactc aatctccttt ctaagcctct 149460 tcctcatatg caaaaaggga ataataagtg ttttataaga ttcatgcatg atataatgta 149520 tgcaaagtgt ttagcatggt gcctggcata tcataactgt taaacaatta ttagccagct 149580 cctagcattt tgggaggctg aggcaggcgg attgcttgag gccagcagtt caagaccagc 149640 ctgagcgaca tagtgagatc ctgtctctac aaaaaaaaaa aaaaatgtgt tttcattagc 149700 tgggtgtgtt ggcatgcacc tgtggtacca gctacttggg aggctgaagt gggagaattg 149760 cttgagcctg ggaggttgaa gctacagtca gctgtgattg caccactaca cttcaaccat 149820 ggcaatagag tgagaccctg tctcaaaaaa aaaaattatc agctattact ataattattt 149880 ttattagttc ctcactcacc taaaatctca aacacacctt agaaatacac atatgagaac 149940 aaccaaaaat gacaaagtag aagcacatat gaaaaggcta agaaagcatg aaagccagca 150000 agaaataact gccgctcttc tggtcagcct ggaaagcaac tggcattttc cctagaacaa 150060 tgttttcaaa cttggttgca cattaaaatc acctagagac cttttaaaaa ttctgaaacc 150120 caggccacac cccgacaaat gaaagcacag tctctggggg tgggacatag gcatcatttt 150180 ttgaaggtcc ccacttgatc ctaatgtgca gacaaatttg aaaaccacag ctttgggagg 150240 ctgaggtggg tggatcataa gatcaggagt ttgagaccag cctggccaat atggtgaaac 150300 cccgtctcta ctaaaaatgc aaacattagc tgggcatggt ggcgcatacc tgtagtccca 150360 gctactctag aggctgaggc ggaagcatca gtgagggaga atcagtgaac ccaggatgtg 150420 gaagtttcag tgagcccaga tcacaccact gcactccagc ctgggcgaca gagcgagact 150480 ccacctcaaa aacaaaaaga aagaaagaaa aaagaaaagc agtactctgg aacctaccaa 150540 tccatcattt agcatatttg tgaagtaaag tgttattctg gtatttgcag aaccagaatc 150600 cagctttatt gggccaggcc caattttttt aaaaaacatg gtaaggtctc ccagccttaa 150660 agtattacat agcatagctc taaaagatca ctgtaggaag acataaaatg gtatttcagt 150720 catctaaggg aaaaaccttc ctaaagcact agcccctgga caactattat ttaaacatct 150780 acagctgttc aatagatatt gggttctttt tggagggatg tgacaaaatt cttgtataat 150840 tagattgtga tgatgattgt atcagtttag tacatgtaaa tacactgaaa accattggat 150900 tatacacttt aaatatgtga tttgcatggt atgtgaatta tgtctcagta aaaatctaga 150960 gatggggctg ggctcagtgg ctcacgcctg taatcccagt acttagggag gctgaggcca 151020 gcggatcacc tgaggccagg agttcaagac cggcctggcc aacatggtga aacttcatct 151080 ctactaataa tacaaaaatc aggccgggcc tggtggctca cgcctgtaat cccagcactt 151140 tgggaggcgg aggcgggcgg atcacgaggt caggagtcca agaccagcct ggccaacatg 151200 gtgaaacccc gtctctacta aaaatacaaa aattcaccag gcgtggtggc tgaggcagga 151260 gaatcgcttg atggtggagg ttgcagtgag ccgagatcgc gccactgcac tccagcctgg 151320 gtgaaagagc gaaactccat ctcaaaaaaa aaaaaaaaaa aaaaatcagc cagatgtggt 151380 ggcaggtgcc tgtagtcaca gctacttggg aggttgaagc aggagaatcg ctttatctca 151440 ggaagcagag gttgcagtga gccaagatca tgctgttgca ttccagcctg ggcaacaaga 151500 acaaaactca ctccatctca aaaaaaaaaa aaaaatatct agagatggga gaatcatatg 151560 gctggcataa aaaggtcaag tcaaagatat gtaagattaa ggctttacga tgctccagtt 151620 ctagtaaaac agaccaggta cttgttttgg tgtgaaattg ccaatataag tatagtactg 151680 tacatattag ttgtttagct taggtaagtc ttttaatctc tttaaactcc agtttcctca 151740 tctataaaat aaagagaata tctactttgc aaacttgttg tgagagtgaa aagtaatgca 151800 tataaagtcc ctgtatggag caagtactca ataactattt gttgaactaa aaatgataat 151860 actgatattc accatttatt agcatcccta tgtgccagac actgtaaaca attaaaagtt 151920 atcattctgg tacccagagt acagtatgag acagacatgc aaaaaaaaaa aaaaaaaaag 151980 ataatggaga tctgcatagc ataagatgca gtgggaccaa acgggaaaaa acacctaaat 152040 gagcctggag aaaggaagaa atgatagagg tggtgatgct tgagctatga tctaaaggtt 152100 gagtagtagc ttgtcagaca gtaaagggga aaggacaggg cagggagggg ccattgcaag 152160 aaattccatg cagagggatt atggtatttc attatcactg aaccttaaac tgtgtgtgtg 152220 gccgggtacg gtggctcatg cctgtaatcc tagcactttg ggaggccaag gtgggcagat 152280 cacttgaggt caggagtttg aaaccagcct ggccaacatg gtgaaacctc atctctatta 152340 aaaatacaaa aaattagcca ggtgtggttg tgggtgcctg taattccagc tacttgagca 152400 gctacttgag aggtcgaggc aggagaattg cttgaacccg ggaggcagag gttgcaatga 152460 gctggtgtca ggccactgca ctccagcatg ggcaacagag agagactcca tctcaaaaaa 152520 aaagtgtgcg tgtaaaacag acagtctttg taggagatga ggtgaagcaa gtaggcagga 152580 gttagatcct gagttacctt tgggccaagc caaggagttt ttattttatt ccatatagat 152640 gacagtcact gcagaaattt gaactgatat gcatatatca tgaggttttt ttgttttaga 152700 aatattattc tgtcagtcat aagtgaaggg actggggaca ttgggactgg aggcaaagag 152760 atcttatctc tttgcaatag tttgaaagct attgcaatat ttgaagagaa gattgataaa 152820 tgcttgaacc agcacagtgg cagtacagat ggagggagct gactacaata aaatcatcag 152880 gacttgttga ttgacatgat ataggaagtg agggacaggg atgagtcaag gctgatcccc 152940 ctagatcctg actaaggaag ctgggtggtt gacagtgcca ttcacagaga cagtgaattc 153000 tggcataaac acctaatagg tcaggctggt ttacacctcc atcattccca tgggagaagg 153060 tatagagggg tgtgtgtttg tgtgtgtgtg tgtgtgtgta aaagaacaca gaaagccaga 153120 ttcctctttt tgacaccaga atattggttc ccaccatagt caaaaggata ttcctgagga 153180 tcgaggcttg gaaaaatatt ggggaaggat aagaactcca gttgttgctg ctttttttgg 153240 cagccagtgt aacctaggta aggacttggt tgaattaaga aatttcatgt ccagatcagg 153300 atggattttt ctatttctct gagctctggt gtgtttccca ctcagattgc aggtcgtagg 153360 tacctacggt gtgaattgtg ttgtgtttct gtgcttgtgc aagggagtag ctaggttgct 153420 gggaggtctg gatgagggtg ggggtggggt gagatcaagt ctccagctcc aagaggtccc 153480 ctggggctaa gtgaaaagct tgctcttttg aaatggtctt cgttggtaat taacaaaaga 153540 tcaagaatac cttggtgtca gataaaggga atttgtaggc acaatgctgt tggtagctga 153600 tctcaatcat tcaaggaagc tattaaatct atgaacatta gcattctgcc aggtaaagag 153660 atctggtcct tagcacctcc cagacacact gattctttac tgttttgaaa catctccctc 153720 tcctggcttc ctccaccccg cttccatact gtccttgaaa tcaatgaatg gtaatttagt 153780 gtatctagtg tatcactagc aaatgtctga ataagaaagg tttggtttcc gctgtgtctc 153840 ctgttacaat gagaacatgt actgcataaa tttaattggc tacgttaatg tgtaagcctt 153900 ttctgcaaag agatggatcc gtttctgaat attctgcaga agggcagagt tttgagtata 153960 tggcagtggt tctaattagc agttgctcca atacaatcag actgagacgg aagctactca 154020 tttagaatac tggttgatga caacactggc ttgaacaaag tgaccactct ccaatggcta 154080 ctctccctct cagtgggccg caggttgcta gggctcaggc tgtggctgtt ttccccgccg 154140 aaaaggggcg gggtcagtcg gtgtgttagg aaaaaaaatg tatatatata tatatgttgt 154200 ctgcctcccc acagagataa caacccgtgg aaaaacatgc cgttgagcgg gaggaaggcg 154260 aaaagatagg ctgggttttt tggggggtgg gggagcgtgg aggatagggt gggctttttc 154320 ccctccaatg ctgcgacgca ttaaccctgc tgctgttggg acgttctctg ctcagcctat 154380 tggctgagcc cgggagccgc tgtctgccaa tcgggtggtg aaaggcagac aaatctaccc 154440 cgccaccagc aaaaacggcg cgtaaccctt gcggcgccgg ccgaaccgcg ccagagctgg 154500 cgcggggaaa gggagatagg tgtctccagc tgctgtggct gtttggggcg ggtcggcttc 154560 atccgcgtct caggagcaag tagagaatta gcgggcggca gcaatgctcc gcaaggtgag 154620 aagctggaca gaaatctggc ggtgggctac ccttttgttc ctcttttacc acctgggtta 154680 cgtttgtggg cagatccgct acccggtccc agaggagtca caggaaggga cttttgtagg 154740 gaatgtcgct caagatttcc tgctggatac ggacagtctg tcagctcgca ggctgcaggt 154800 cgctggagag gtgaaccaaa gacacttccg tgtggatttg gacagcggag ccctgctcat 154860 caagaaccca atcgaccgag aggcactgtg tgggctcagt gccagctgca tcgtgcccct 154920 ggagtttgtc accgaaggtc ctttggaaat gtaccgagca gaggtagaga tcgtagatgt 154980 gaatgatcac gccccccgtt ttccgcggca gcagctggac ttggaaattg gggaggcagc 155040 tcctccagga cagcgtttcc cgttggaaaa ggctcaggat gcagatgtgg ggagcaattc 155100 gattagcagc tataggctga gctccaatga acactttgca ctggatgtga agaagcgcag 155160 cgacggcagc ctggtcccag agctgctcct ggagaagcct ttggatcgag agaagcaatc 155220 ggactaccgc ctggtgctga ctgctgtcga tggagggaac ccgccgagat ctggcaccgc 155280 agagctccgg gtatccgtgc tggacgtaaa cgacaacgcc ccagccttcc agcaatccag 155340 ctacaggatt agtgtgttgg agagcgcacc agcgggcatg gtgctcatcc agctcaatgc 155400 ctcagacccg gacctgggtc ccagtggtaa cgtcaccttt tatttcagtg gtcatacccc 155460 tgatcgtgta agaaacctct ttagcctgca ccccactact ggaaagctta ctcttttggg 155520 gcccctagac tttgagagtg agaattacta tgaatttgat gtgcgggctc gcgatggggg 155580 ttctccagcc atggagcaac attgcagcct tcgagtggat ctgctggacg taaatgacaa 155640 tgccccttac atcacagtga cctcagagct tggaaccctc cccgagagtg cagaacctgg 155700 cactgtggtg gcacttatca gtgtgcagga tccagactca gggtcaaacg gagatgtgag 155760 cctccgcatt cctgaccact tgccatttgc cctcaagtct gccttcagga accagttctc 155820 cctggtgact gctggaccct tggatcgaga ggccaaatct agctatgaca tcatggtcac 155880 tgcttctgat gctgggaacc ctcctctcag tacccacaga actattttcc tcaatatttc 155940 agatgtgaat gataatccac cctctttctt tcagaggtca catgaggtgt ttgttcctga 156000 gaacaatcgc ccaggggacc tgctttgctc ccttgcagcc tctgacccag actctggctt 156060 gaatgcgctt atctcctact cactcctgga gcccaggaat cgagatgtat cagcttcctc 156120 tttcatctct ctgaaccccc agacaggagc tgttcatgct actcgatcct ttgactatga 156180 gcaaacccag acactgcagt ttgaggtgca ggcccgggat cggggcaacc caccccttag 156240 cagcactgta acagttcgtc tatttgtgct ggacctcaat gacaatgctc cagctgtgct 156300 ccgtcctcgg gcccggcctg gttccttatg tccccaagca ctgcctccat cagttggtgc 156360 tggccaccta atcacaaagg tgactgctgt ggacttggat tcaggttaca atgcttgggt 156420 ttcctatcag ctcctggagg ccccagatcc cagcctgttt gcagtctctc gatatgctgg 156480 ggaggtgcgg acggctgttc ctatcccagc tgacctccca ccacagaagc tggtcattgt 156540 ggtaaaggat agtggtagtc caccactctc tacctctgtt actctcttag tgtccttaga 156600 ggaagacact catccagttg tcccagatct tcgagaatct tcagctccaa gggaaggaga 156660 atctcgtcta accctctact tggctgtgtc cctagtggca atttgctttg tctcctttgg 156720 ctcattcgtg gcactactct ctaagtgtct tcgtggggca gcctgtggag tcacatgctt 156780 tcctgctggc acctgtgcct gtctcaccag atctcgaagg agggaggggc ttcccccttc 156840 caatgggatc ctccgaatcc agctagggtc agatgaccct atcaagtttg ttgatgtggg 156900 aggccactct catggctgta cacccttggc ttctgcaccc actcggagtg atagcttcat 156960 gatggtgaag tcacccagtg cacctatggc aggggagcct gttcgcccaa gctgcccacc 157020 ctctgatctt ctctatgggc tagaggtgag acctttgcag gctcaacaaa tgcttgaggg 157080 ttattctgat ccaggcatat ggctaggcca tgtcctagag agtactggcc tctcagtaag 157140 tgcccatagt gatgtcacca tttttgtaag aggtaactat gtggtagacg ctgtgctttg 157200 taactgtttc gtgaattaac cagagttgtc acagtttagc attgggggcg ggtcatgcct 157260 atatctgagt aagaaatgaa agtaattggt gatcaagagc caggctgttg tggaagcatg 157320 atgatggaat gtgggagcac aggaggctac agtgcacagg gtacagtgca ccaggcagtc 157380 acttggacaa aggtggctgt tttctctact cttcctgaaa gaggggatca gattctgaag 157440 taccttaact ctaggttacc atttcccaag ggattgaggg gaaataaaat ctttgtctcc 157500 cagtatctag tacactgtga agggacctct ctatttgaaa catagagaca gcagaaagag 157560 gagagaacta aaggaataga gaggcacgca tcagagtggt ggcatagatc ttttggtctg 157620 ggtcttagga ctcatatcaa gtccctactg gggatttgaa ctagatgcgg taaattggaa 157680 ggttggggcg ggttggtcat cacctttgga aaaaacagta agtgaaatca cttatgtcag 157740 aaaactggtt tacagttggc tgattcatag aaacagccac cctgtgcatc tttaagttga 157800 gttctcctga atttggtgaa accatgaaac ctagaagcca agccatccat gcttggcctc 157860 tgaccaccct cctgggtgac ctgattcagc cccagaaatg ttcccctacc caaaaactgt 157920 aacactcatt ccacatttgg ggtctggggt gtcagaaaag ctaagtccca tgtcagctga 157980 cattgagatt tccgcaaagc attgctggag agtcagggca agactttaca aggttcttac 158040 taatcttttc tctcacctta gcagcattca gcaggatggg ggagggtggg ggaatacatg 158100 ggctttgcct ctcccagaag gacaagattt tgctggttca agcaaagtgg tggaagcttc 158160 tgaagtcatg caggaagttg ctgggacaga acgctgagga gttttgtatc actttgtctt 158220 ccctgttgag taccatctga gctgtcaaac tttgctgcca agggggctga atcaacctgc 158280 agcacgaagt gagtggggag gtaggaagct tctgtgacac agatttgcag cctgtgttcc 158340 caaggtttcc aggattgagg aaactccata attggttgag agcacacaga ctttttggcc 158400 aatcagactc agagctgagg tgggagatct gctcttccag cccgcctctc ctcctccagc 158460 tccccagctc cactcaaatt cagctcccct cccccctgcc cacccccgcc actcggtgac 158520 taagaactgc tgcaagcagg caaacctccg agcagttttt aagaggctgg aaggagacat 158580 aagagacttc agctgctgca ttccaagccc tgggtctacc ttggagacag gacagcacag 158640 acttactctc cacaaaggga cttctgggtc atggggccca agacactccc acagctcgct 158700 gggaaatggc aagtgctgtg catgttgtcc ttgtgctgct ggggctgggt gtctgggcag 158760 cttcgttact cagtggtgga ggagtctgag ccggggacgc tggtggggaa tgttgctcag 158820 gatctgggct taaagatgac agatctgttg agccggcggc tgcaattggg ctctgaggag 158880 aatgggcgct atttttccct gagcttgatg agtggtgccc tggcagtgaa tcaaaagatt 158940 gaccgagaaa gcctatgtgg agccagcacc agctgcctgc tgccagtgca ggtggtgact 159000 gaacaccccc tggagctaat ccgtgtagag gtagagatcc tggatctcaa tgacaactct 159060 cctagctttg ccacccctga gcgagagatg cgcatctcag aatcagcagc atctggggca 159120 cgattcccac tggacagtgc ccaggatccg gatgtgggca ccaatactgt gagcttttac 159180 actctaagcc ccaacagcca cttctctctg aatgtgaaga ccctaaaaga tgggaagcca 159240 ttcccagagc tggtgctaga gcagcagctg gatcgtgaag cccaggcaag acatcagctg 159300 gtgcttactg ctgtggatgg ggggacccca gcccgctcag ggaccaccct tatctctgtc 159360 atcgtgctgg acatcaatga taatgctcca accttccaat cctcagttct acgtgtggga 159420 atcccagaga atgcacccat tggtactctg ctgctccgcc tcaatgccac tgatccagac 159480 gagggcacca acggccaact agactattct tttggagacc acacatctga ggcagtgcgg 159540 aacctctttg gcctagaccc tagcagtggg gcaatccatg tgttgggtcc catagacttt 159600 gaggagtcac gtttctatga aattcatgca agagcccgtg accagggaca gcctgccatg 159660 gagggccact gtgtgattca agtggatgtg ggggatgtca atgacaatgc cccagaggtg 159720 ctattggcct ctttggccaa ccctgtccta gagagcacac cagtgggcac agtagtgggg 159780 ttgtttaatg tgcgagaccg ggactcaggt agaaatggtg aagtgagcct tgatatctct 159840 ccggacctgc catttcagat taagccttct gagaaccact actcgctgct aaccagccag 159900 cctttggacc gggaggccac atcccactat atcatcgagc tgctggccag cgatgctggt 159960 tcaccttccc tacacaaaca tctcaccatc aggctcaaca tttcagatgt caatgacaat 160020 gcaccccgct tcaaccagca gctttacact gcttacatcc tagaaaaccg gcctccgggc 160080 tcccttcttt gcactgtggc tgcctcagat ccagacactg gggataatgc ccgcctcacc 160140 tactccattg taggaaatca ggttcaggga gccccagcct cctcctttgt gtatgtcaac 160200 ccagaggatg gacggatctt tgcccagcgt acctttgact atgaattgct gcagatgctg 160260 cagattgtgg tgggggttcg agactccggc tctcccccat tgcatgccaa cacatctctg 160320 catgtgtttg tcctagacga gaatgataat gccccagctg tgctgcaccc acggccagac 160380 tgggaacact cagcccccca gcgtctccct cgctctgctc ctcctggctc cttggtcacc 160440 aaggtgacag ccgtggatgc tgatgcaggc cacaatgcgt ggctctccta ctcactgttg 160500 ccacagtcca cagccccagg actgttcctc gtgtctacac acactggtga ggtgcgcaca 160560 gcccgggcct tactggagga tgactctgac acccagcagg tggtggtcct ggtgagggac 160620 aatggtgacc cttcactctc ctccacagcc acagtgctgc tggttctgga ggatgaggac 160680 cctgaggaaa tgcccaaatc cagtgacttc ctcatacacc ctcctgagcg ttcagacctt 160740 accctttacc tcattgtggc tctagcgacc gtcagtctct tatccctagt caccttcacc 160800 tttctgtcag cgaagtgcct tcagggaaac gcagacgggg acgggggtgg agggcagtgc 160860 tgcaggcgcc aggactcacc ctccccggac ttctataagc agtccagccc caacctgcag 160920 gtgagctcgg acggcacgct caagtacatg gaggtgacgc tgcggcccac agactcgcag 160980 agccactgct acaggacgtg cttttcaccg gcctcggacg gcagtgactt cacttttcta 161040 agacccctca gcgttcagca gcccacagct ctggcgctgg agcctgacgc catccggtcc 161100 cgctctaata cgctgcggga gcggagccag gtgaggggct cggcgccgcc ccgggcgacc 161160 cctgggggcg gcactggaga agccgcccgt cctcataagg gattgaactt gcatccactc 161220 ctctccggcc ggcttggtcg ctggctgcgc tccacccgat tctcgggatc attggaccgt 161280 ttgcgcgaaa ccagagtggc cgattaaggg atggggctcc gagcaccggg ggtggtggcg 161340 actgtgggcg aggggaggtg ggaccgaccc ccacccctac actcaaaaaa ggccggggcc 161400 tccttcgagc ttccggtgaa tttcgggcga tttccgcggg tgtcgggggt cccgggagga 161460 ggcagtcaca gatccacccc tgcagccagc ctcctaggcg ccggctccgg cacgcttcgc 161520 cggtctgtag atttcctctt cgatttctcc ccagctccca gcatctgtga cttcactgtt 161580 accctcccta tccccgcatc acccaaccgc acctgtctgc gggacttagg tgtgcgcgcg 161640 gggctcatgc gtgtcctccc tgctggccac ccccacggcc cacacaagtt gcacgggctc 161700 gccacgcccc gccaacacgt gcgcggacgc acgcacgcac tcctcgcacg tgggcttacg 161760 cgaataccag ctttcactgc cactcgctcg cggccagatt cacaggcctg ttccggtcca 161820 ctcgcagctc ccctctgccg ctccctccgc cgggctcagg agtactcgta gctgattgtg 161880 cgcgcctgag ggtcccagat cgcggccgcc caggaccagg cgaggactcc ggagcctcct 161940 ctcacctctc ccacctgcgc cccgggctgg gccgggtcgc ctggggggcg gcctgagcga 162000 ggcgcggggc caggagcgct ggagcgactg ccgctctaag tgccgggcgg gcaggactct 162060 acgatccttg ggccagaggt ccggatggtc ccgggactcc gtctcaaggg tcggcgaccc 162120 ctcaacccag aagcctcgag caggcggaca ggcagagctg cccagtggcc gaggcgcggc 162180 agggctccgc gttgggcgag tgagtgagcc tctataggac agcaggactg ggactccagt 162240 ggcaccagcg gccccttcct cccgcaggaa gtgaaagcct cgagcgccct ggctctcaac 162300 ccccagagat acaggctttt ggcgccgtcg tgatcacaat gtgcccagcg atctagggtc 162360 agagatttgg aggtgaccaa actatctgac actctaacaa gtcctgtctc ctctggcaga 162420 tggaaagcta taggctctgc cagatgccag ggtgccctta tgtgtgagga aactacaata 162480 gtaaaaaaca caagtttctc caactccagg agcttttatt caaaatatat caatgcctaa 162540 ctctgctcct aggactgtat tttgaaacac ccccaggtga ttttgatagc tgattgagag 162600 aaacttacta tataactcct ttgagaacct catctcattt gctcttccca ccattgctgt 162660 tggctaggta ctaacatgcc tctcttataa cagcttcaca gaggtcaagt gacttgctca 162720 agttcacaga gcaagtaaga gagattctaa cccctgtcta actccagaat gtgtgctttt 162780 aatttcttgg cacttggaac tttaaaagct tgaggacagg agaggggagt tgcctctgct 162840 gggattttgc ttctgctggg atggggcaag ggtggggttc cttccctttt aggaccttac 162900 atgtggggaa agtcttctgt ggctcctcat ttctgagcag tccccgcagc gcaaacttgg 162960 ccagttatcc ttttggagat tgagttcccc cagctccgtt tcctcctatc acaatcactg 163020 catttccatg tagattctgc tgtgtctaag aatacagtgg ctgagggctg gccatccctg 163080 tgcccttctc catggcagcc ccagaatggt gctggtgact cccgatacac ctggaatgct 163140 aggtttctgg gttctgctca tatcactgcc acctgtgagc cttgagtgag ccactggcag 163200 ttccggagct tccttctccc tggagtaatc tgagatactc acactctctg cttctgggag 163260 caagtatgag tattaattac cagcccaccc cagaaccagt gaggaggtgg ctctaggagt 163320 gctccatgag agtgtgtgat gggataacac accccctgga aagaccagaa gggactcagg 163380 aatgaagtgg ctggccagag ccccacacct tcagctaggt gggagatggc tacacatcag 163440 ccccttggga gccctggaga cttagttggc cctgcttgga ggctgtggga gctggatccc 163500 tccccgctgc atcccttcca tttttctccg tctcagacag agcagccttg ttctcttctc 163560 cttagtcaca gaccattgtc tggcacggag ttctaggggt gagaagtgtc ccgggacttg 163620 gatgccccgc aaaggcccaa tctggcatga ctcctaaatt aataatgtat ttagctgtgg 163680 gaagagattc ttgcaagcca agggcccaga gaagatgtcc ctgtgaatgt gtcactgcac 163740 aacctggcac caaaagggtt accaagaaca gcagccatct tgctgcagag gatgctttgt 163800 tcccagctga ggagttgaat aaattcattc tagggctggt agaattctca ttgaaaagcc 163860 tcctttgcca ctttaggggg ctttgtctgc acctcttccc ccagttccac agaagatgcc 163920 ttcagtcctt gaattttggc tcaggagttc tgactctggg ggcagggagg aaggggccat 163980 ttctttagga aaggagtctc agcttgctca ctgtggtcag atgaaatgtg atttatctct 164040 tggtttctgg tacctcagac ctctgagacc tgaggtgtat tttgtctttg gagatgagtc 164100 cacccctgcc ccctcttagt ccgttttctt ctctgtgccc actcccctcc ttctctcccg 164160 gcccatccct aggggctcgg gtgacattct aacttctcac gggtactcag cccctttccc 164220 tctgttttct ccacagcaag ccccgcccaa cacggactgg cgtttctctc aggcccagag 164280 acccggcacc agcgggtagg tgactgattc tccagcccac cctcttctct gcggcatttt 164340 ctcagggatg acgtgggagg agatggggga gggcccagca tttgctacag atggcttctc 164400 cctcagtttg agatcccagg gaggtcttgg tgtgcggggg gctggcacac agaccccgga 164460 aggaagaggc gactgccctg actgttcagg aagctcaatt cacatgcttg ccccttccct 164520 cctcgccacg accggcacct tttcctatcc cctgagggca ctgtggaacc aaaggatggt 164580 cttaagctgg tctctgggtg aaagcgaggc tttctatgcc catgtactgc ctaaccccct 164640 cccctgagtt gagctgggct ccattatgac ctggggctca ggcagaaaag catttgaccg 164700 gaggaggcgg tccgcactca gcgcctcctc cagagcctcc agagccgagg ctgactgcag 164760 cctggggaga gtggaggcag cacagctgga ggtggaactg aggaaggact gggcggggca 164820 tggagcaggc ccccttctcc ggcccctcct cccactgtcc tctgccccta cttgtcctgc 164880 tctctgtctg tggggtctcc gtgtctctgc ccctttttct tgagtttccg tctttgccac 164940 tttctcttac ctctcagtcc ttccctcagt ctctatctcg ctttgcaatc tctgcctctc 165000 cctctcttct ccatctctgt cttagcttcc gtcttgattg ctgcacctca gcctcagtcc 165060 ctttcatttg tctacttgca ttgatctgtg ccgcccactg tgcctgccat ggcataagtg 165120 ctcaataaat gtggagtgag taactacacg ggacccttag tctctttctc cttctctatc 165180 tctgcctccc tgtccttgtc ctggacctct tttctgtttc tcctttcacc gtttcctagc 165240 gccttgtgtt cttctatccc cagcctctat gtttctctgt ctctcactat ttctgctttc 165300 ctctctgttc tttgtctctc tttgtctctg tctctgtata tctttctttg tctctgtctc 165360 tggtctctgt gcctgttgtc tttttctgcc tctttctctg ttactctttc tttatctctc 165420 tttttctttt atcttgtctt ttttctctga gcctctgtct ctgtctctca tttttttgtg 165480 cttgtgggca agccagcaca cacaaccccc cacccaccac ccaccaacac cccgctctct 165540 tccttccctg cccctcacac actgagcctt tgatcgcagc tctccaccag acaccctccc 165600 atccaagcag ccccagctgc tcatttcaat ctggtatgaa ttcctgctga gacaggaacc 165660 ccctgcgggc tgaaggggag ggaaacttca gcagaaagac cttcagttgg tctgagcaga 165720 gtgggatagg ctctgcgcca ggcctcccag ttagaagtca ggagcctgga ggagtctcag 165780 agcccaggga gagaagcagg agcttgggcc accttaccct acctcctcaa tggttgagta 165840 cttgctgtcc acatttgcca agttgctaca gatgctgagc ttccaagagt tatctttccc 165900 ccatcctgca accaaccaaa cccttgttgc cacaaggacc caggagccct tggtgtatgg 165960 cagagattcc agcttctggg catgcacagt cctgtcaccc attttaggaa cgcaaagcgc 166020 ttcttagaag gcccctaaaa agcagcagat caaaaggctt gggctgccct tgcccttcct 166080 ttgaccccag ctgttgtcct tctccctgct ggccttgcca accttctcat aagttatcca 166140 ttaagtcatt aatgtattca ttcgttcatt tattcaacaa atatttatcg agcatctact 166200 atgagcaggg ccctgtgcta aacattgggc tataggagtg aacaagtaga tgtgatccca 166260 gaactcatag gcttccagac cagcagagga gactgaaaat ttgcaacaag taacacttaa 166320 aaaaaaaaaa aaaggctggg cactgtggtt cacgcctgta atcccagcac tttgggaggc 166380 caaggtgggt agatcacttg aggtcagggg tttgagacca gcctggcagc caacatggtg 166440 aaaccccatc tcgattaaaa atacaaaaat tagccaggcg tggtggcagg cacctgtaat 166500 cccagcgact taggaggctg aggcagaact gcttgaaccc ggaaggcaga ggttgcagtg 166560 agctgagatc acgaaaaaaa aataatctag ccacaaatca cagtaagttc tgagaggcag 166620 agaacaatgt gagtgtaatg ggggggggaa gatcagagaa ggcttctagg aggaggtgac 166680 attgagaagt tctaggccat ttatgttccc tctacctacc accaccccag gccatacact 166740 ggctttgaag cagaattcac cattgaacct ggaagcccca ccaactgcct ctcatgtgtc 166800 ctctggggtg agcaccttac ccctgcctca actcccattc catcaaatga gaggcttagt 166860 ggcctggaat acatgtggga gctcttggag atatggagga gaaggtgcgg aacctctctc 166920 tctctcctct ctctgcttcc ttagttaact tgtggaggat gcaacaaacc tttttttttt 166980 ttttttttag acagagtctt gctctgttgc ccaagctgga gtgcagtggt gcgatcttgg 167040 ctcactgcaa cctctgcctg ccaggttcaa gcgattctcc tgcctcagcc tcccgagtag 167100 ctgggacagc aggtgtgcac caccacaccc agctcatttt tgtattttta gtagagatgg 167160 gtttcgccac gttggccagg ctggtttcaa actccccgac ctcaactgat ccacctgctt 167220 cagcttccca aagtgctaga attacaggtg tgatcgcccc cggccacaac aaacattttt 167280 gattcagcgg ctccaaagtg aaataagcgt taggatctag tccagtaact tcaacttctc 167340 tccttcattc attcaacaaa tggtcagtga gcactttctg ttggccaggc agtgttctcg 167400 atgtgggagg cccctgccct caaggagttt acagtgcact gaaggagaca aatattgacc 167460 aaataattac aaaaataaat gtgagactga aactgtcata agtgctaggt agaattgtat 167520 ctggtggtgt gggcgtataa tagggatttg atttagggag caggaggaca tcctggaaat 167580 gaagttgtgc tgagatctga aagacaaata caaattaacc agctaaagaa aagaaggaag 167640 agcattccag atggtcaggc ataccagctt caaagcaggg ctggtgttga gttcttcagt 167700 aaacttggtt caagatcaag ccagctctgg gtcacactgc ctacacagaa ggaagagcat 167760 tccaaatggg aaaagcctat gcaaaagcct tgtggtgagg cctcctggga tcaagggaat 167820 ggcagggagt tttctctttg ctggcactgg agtgagggga tgaagaggag aggttccttt 167880 tatccagtct aaccctggtt ccagccttct gttgatgccc tgcctcactc cctccccacc 167940 atcttgccca ctgccctcca gcctggtctg gtcagacaca ccagcttcaa agcagggcta 168000 gtattgagtt cttcagtaaa cttggttcaa gttcaagtca gcactgggtc acactgccta 168060 gacagaagga agaagacctg gccaggtgtg gtggctcacg cctgtaatcc cagcactttg 168120 ggaggctgag gtgggtggat cacctgaggt caggagtttg agaccagcct ggccaacatg 168180 atgaaacccc atctctagta aaaatacaaa atattagcca ggtgtggtgg tgcacacctg 168240 tagtcccagc tactcaggag gctgaggcag gggaatcgct tgaacccagg aggcggaggt 168300 tgcagtgagc tgagatcaca ccactgcact ccagtctggg tgacagagcg agactccatc 168360 aggaaagaaa gaaagaaaaa gagagagagg gagggaggga gggaaggaag gaaggaagga 168420 aggaaggaag gaaggaagga aggaaggaag gaaggaagaa aagaaagaaa aagggagaaa 168480 aaatgaagaa gacttacatt ctgaagttcc tgcttggcac atgcttctcc tccccaccac 168540 tatcccttct caggtcatcc tttgggtgtc tgatcccaat agctgttgtc tcaagctctg 168600 agcccagcaa accatttccc ccttcttagg ctgtaaccca ggccctgccc tgcagctgtc 168660 cccagcctct gcacaaagag tctccatttg gtccctagac tgttctctga tggctccaca 168720 ctaccatccc tcctctgaga gacagtatcc ctgctctctc tcagtttggg cagtcattca 168780 acaaacaaat agcaacttaa tttttttcca cttataaaat agtacatgct cattatagaa 168840 acatgaaaaa tagaaaaaaa attaaaagga aaaccaccca tcattttaca atctagggag 168900 aaccaccacc aactacagtt taatatgaaa catttcaaat atgtacaaaa gtagagagaa 168960 tggtgtcatg aacctgtatg ataccactat ccagcttcaa ctaatgcctt atcttgtttc 169020 acctatatcc ctacccttat cctgtccttg gattcttttg aagcaaatct cagacatcat 169080 ataatttcat cttggtctcc accatcttta acagatgact tttttttttt tttttttttt 169140 tggagacaga gtctcactct cttgcccagg ctgtggcaca atctcagctc actgcagcct 169200 tcgcctcccg ggttcaagca attctcatgc ttcagcctcc taagtagcta ggattacagg 169260 tgtgcaccac cacacacagc taatattttg tattttcagt acaaacaggg tttcgccatg 169320 ttggccaggc tggtcttgaa ctcctggcct caagtgatcc accctcctcg gcctcccaaa 169380 atgttgggat tacaggtgtg agccaccttg cccggccaga tgattctttc ataaggtcca 169440 cattttatat ttgagtgagt gtctcttaag tatcttaatg ctcttttaat gtaaaagact 169500 tcccctccat cttccatttt tgcaatttat ttgttgaatc cctgcctttt catatatatc 169560 tttctaaact tttctttgtg taatcaaaga acatgcatga gcttcatttt tatttttatt 169620 tatttattta tttatttatt tatttattta tttattgata cgtagccttg ctctgtcacc 169680 caggctggac tgcagtggcg caatctcggc tcactgcaag ctccgcctcc caggttcacg 169740 ccatgctcct gcctcagcct ccagaatagc tgggactaca ggcgcccact accacgcccg 169800 gctaattatt ttgtattttt agtagagacg gggtttcacc gtgttagcca ggatggtctc 169860 gatctcctga cctcgtgatc cgcccgcctc ggcctcccaa agtgctggga ttacaggcgt 169920 gagccaccgc gcctggccga gcttcatttt aaaaaaatct cattcaccta aataagttgt 169980 tcacaaactt gtcacacttt catgtgacac tttattcaca tattaagaac tgttattccc 170040 agtcatacgg tacatttcct actagttttt taaaaatagc aactgaggcc atactgtcca 170100 acagaattat agcttttttc ttctttgcag tgtatcatga gaatttcccc atgtctttca 170160 aaattcttcc caagtcattt gcagagtaac tcctcttatg aatatacata ttattttaca 170220 gaataagtcc tcatatgaat atacatatta tttttctaat gctaatgggc ttttgctaca 170280 ttagaaaaca tacacattca tttacaattt tttttttttg agacagtctc gctctgtctc 170340 caggctgggg tgcagtggcg ccatctcggc tcactgcaag ctccacctcc tgggttcaag 170400 caattctcct gcctcagcct cctgagtagc tgggactaca ggcacgcgcc accacgccca 170460 gctaattttt gtatttttag tagagacggg gtttcaccat gttgaccagg atggtctcaa 170520 tctcttgacc tcgtgatccg cctgcctcag cctccctaag tgctgggatt acaggtggga 170580 gccaccatcc ccagcctcat ttacatttta acacaattaa attcagggtg ttgtcagggt 170640 gacttcctag atttctcagt tttttgagca tgatgtaggg agtattttat tatagtccag 170700 tctatgggat attcccttat acacacacac acacacacac acacacacac acacacacac 170760 acaccccaaa ctcaataggg caagaaccat attcatcatc tcttaaatcc taggtcctgt 170820 cacaggccac tgcttggaaa atagttgact aaatgtagtc catttcttcc atttttactt 170880 ttcactattc cccaaatcct ggaagagtcc ctcatatctg ctgctggggc tccaaggcct 170940 ccaagctgaa gcccagtacg ttgttgtgca taagatcata ggccctggaa tcatattagg 171000 ctggctttca ggttgcaact ctaccagttc cagctgtgtg actctggtat agtctctcaa 171060 cctctctgag ccctgttttc atctgttgga aaatatagat aatcacaaca cttatctgca 171120 gggtgattcc gaggataaaa aagacaaata tattacccag tcagcttaga ataggaagct 171180 ctcagtaaat ggttaaaaaa gaggtctctc tccctctgct catctcttac ccagcttcac 171240 ataattggca gcccacccac ctgtttggcc ctcaaccttc aaccatttcc caggacgcct 171300 ccttacactc ctgatcatca tggttccaac cccactgttc cactcagctt tgttccctca 171360 acaccactgc tccctgtgac aggtcatcct cctaacctct ggcatctggt cccgttgtct 171420 ccctgacaac ccgcatgctc tcctccctgc aacccccgcc gcttgcctgc tctccctact 171480 ttattcccat tagccccctt cacctggggc tgagaacacc tggccttgac cctgcaccct 171540 cagccaggcc cacagagctc agtcgggccg gaagtaagga ccccagatat tcagttgagg 171600 aatttaacat taatacaata atatagaatc caccagcaga ttttcataaa tgttctgtgt 171660 gttcttttat cctttttttt aatccaggat tttatcaagg agcatagatt gcatttggtt 171720 gtcacgtctt tcctctcctt taatctggag ccagctccca gtctttttat ttttttaatg 171780 acatggatat ttttaaagag tccaggccag ttgtacttta aaatgtcccc gaacctggat 171840 ttgctggcta ttctctgatg gttagattca gattacacac cttggtagga atacttcccg 171900 cagcatcaca ctgggactca tctaacgtcg gcctgtccca ctatcagtga tgccgagttt 171960 gttcgtgtgg taaaaacagt gtcccagatc tctccattat aaaaatatat ttttataaag 172020 atattttaaa atatttgtga aaatataagt aatctgtgga tgatactttg agataggcag 172080 caacccttca tgcaatttta gtattccctg atgatccttg cctgtatctg tttttacatc 172140 agtgattaca aagcggtgat gttctgtcat tccttctaca tgtatttgct ggtattcttc 172200 tgaaaattac ctggatgatt tcttcagatt taaattcact gtcttttcct tggggaagcc 172260 tggactggct gagctgccta accctgactc tctgtctttt tttttttttt gacagggagt 172320 ctagctctgt tgccaggctg gagtgcagtg gcaaccttca cctcctgggt tcaagcgatt 172380 ctcctgcctc agcctcccaa gtagctggga ttacaggcgt gtgccaccat gcccggttaa 172440 tttttttttt ttaatatcta ttttagttga gacagggttt caccatgttg gtcagaatgg 172500 tctcgatctc ctgacctcgt ggtctgcccg cccctgcctc tcttcatacc ctctggtagc 172560 ccctgacaca gcccatggca agtatcacaa ttgcaattac tctattgtgt aattatttaa 172620 aatcagcctc tcagtgccca ccatgagcac cgtaaagatg gacagtttct atcatactca 172680 cagccacaac cccagcacct ggctctgtgt ctggtacata gaaattgctc aagaaagaat 172740 tgttggaggg gcgcggtggc tcacgcctgt aattccagca ctttgggaag cggaggcagg 172800 tggatcatga ggtcaggagt tcgaaaccaa cctggccaat atggtgaaac cccatctcta 172860 ctaaaaatac aaaaattcgc tgggcatggt ggcatgtgtg cacttgtcgt cccagctgct 172920 caagaggctg aggcaggaga atcacttgaa cctgggaggc agaggttgca gtgagccgag 172980 atcgcgccac tgtactccag cctgggtgac agagcgagac tccagctcaa aaaaaaaaaa 173040 aaaagaaaaa agaaaagaaa taattattga atcaatggaa acagaattac aactcttccc 173100 acttttggga aggagaattg agattcctgc tttccccttc aaccctagct ttatgtttgt 173160 tgtgatggta tagaggtcac acatggcagc cttgtgtctg ttcttaggct gagttcatct 173220 acttagggac ggggaatccc agattgggca aaaccaaaag cagggacaga ccttggaaaa 173280 attgtaaagc agttcttggt tgtgctcacc caccatgaca aaatatgcac acacacaacg 173340 caacacacac acagacattt tcatgccttc aaggcctacc ctacagcctt tcccatggtg 173400 ccaaaccctt cttcttacct tacagtcact taactgtctc tgctggtctc ttcccactca 173460 tttaggcaac aaatatttat tgaaaaactt ctctgagcca gatggtgcca aacagttacc 173520 taaagggcag actgtgtgtg tgccagggct gtttcccgcc aacactcccc tgcaaattga 173580 aataatttca tccttggaaa ttcaaaaaaa tcatgaaaat tgtcactgtg ggaaaattcc 173640 aagtagagct gaaccttcta agaagcagag agttcttctt atggtttagt atttttttaa 173700 attatgaatc atttcatgtt ttttcaacac tcggagtttc taaaagtctc acttaggtcc 173760 aagtgctagg ctttgtgcta ggtgcttcag taggaagcag gtggagtcgc tgcctcacag 173820 aagccagtgt ggtggaggaa cagacaggca ctacaacagc tgcagtgtga ctagtgccat 173880 gtggggcagc cgctgggatg ggagtacagt ggaggcacct gcccagtctg agtggatctc 173940 ctctgatata ttttattcgt gtcatcatgg caaatgttgg gggactggca ttctagggaa 174000 caccatctgc ccaggattca cagcaagagg gaacttgagg gataggaaag tgcaccttgg 174060 aaaaggtttg atgatagagt gtttgagggc ggggggtggg ggttcttgta aaataggagg 174120 ggcaggttct tctatggccg tggattttac tctgagggct taggaagcca ttgaatttta 174180 gaaatttctt ctccctgctc cagggtctct tggggcctcc tacatctccc cctaggtacc 174240 tcctaggtcc ccactttttc tctagctctg gaacattctc ttccatttcc caccttcaca 174300 gtcctctgga gaaggtctga tctccctcac tatgacagga agccaggctc tctcatggtg 174360 ggtgggggaa tgcactatgt tcaatgcatt ggaccagcct ggccaacatg gtgaaacccc 174420 gtctgtacta aaaatacaaa aattagcctg gcacagtggc aggtgcctgt catcccagct 174480 acttgggaga ctgaggcagg agaatcgctt gaacccagga ggtggatgtt gcaatgagcc 174540 aagatcgcgc cactgcactc cagcctggat gacagagtaa gaccctgtct aaaacaaaaa 174600 gaaaaaagca tcggaggcag caaagagctg gtttgaggga ctgacttgtg ggattctggc 174660 ttctgaagga ttgtagaagt gcctcctacc ttgctgagag aaacaggtct tgggcatggg 174720 gtagggttag ggtactaggt ttgggagccc tgggagagga caggaggggc atgagctgtg 174780 ccggcctggg agtctgtgct caccatccta ctctctcccc agctcccaaa atggcgatga 174840 caccggcacc tggcccaaca accagtttga cacagagatg ctgcaagcca tgatcttggc 174900 gtccgccagt ggtaagtggt gtcagtgtgt gtatggaaga gtgggagacc tggggttctg 174960 gggtgcatct cacagccacc atgcccacgg actggatgtc aaacctgtgt agtttctcca 175020 gatctttcgg caggtctgaa aggacccaca attccaaaca taaagcctgg aattgtggct 175080 aaggaacagc agaggggttg ggggtcctgg gatgcctgga ggagagcgaa caaggaaaag 175140 actcatggag ggaatagtgg ttacaagtct agctctggaa tgggacagtg tagctcaggt 175200 cctagctctg ctactatcct tgggacttgg atcgacttgc tcaatctctc taaacctcag 175260 tttcctcagc ctagaaagtg gggacaggga ccccaaaggg ttgttgtaga gattaaatga 175320 gatgatacca caaagcatag agttctgggc ctggcgcttg gaagccctca agcaatgaaa 175380 gtgggtgtag aaatccccag ccgagagaac acctcctctt tatgcgaggc tcctcttttg 175440 ctgcccctaa ctccagagta ggattctggt tttcccataa ggttgactaa gggcttcctt 175500 tgtaatagag attcggctag tggtggttgt ccctgaagag tcactagggc ccagagcagg 175560 agaagaagaa tatcatttgt ccttaagagc acagcctaag ctgggcgtgg tggctcacgc 175620 ctgtaatccc agcactttgg gaagctgagg caggaggatc atgaggtcag gagttcgaaa 175680 ccggcctggc caacatagtg aaaccctgtc tctactaaaa atacaaaaat tagctgggca 175740 tggtggtgcg tgcctgtagt cccagctact tgggaggctg aggcaggaga atcgcttgaa 175800 cctgggaggt ggctgtggtg agcagaaaat cgcaccactg cactccagcc tgggcaacag 175860 tctcgctctg tctcaaaaaa aaaaaaaaaa aaaaagagca caggctttag aggcaggcca 175920 atctggattc aaatcctggc acctggcacc accacttagc aatgagtcct taggtaagtt 175980 attaaacccc ctcggtttca cttactatta atgggcacag tattaacgga tctcattgtg 176040 gtgttaccag ggccaaatgc aagtccctca gcacaggatt ggcagagagt aagggcacaa 176100 tatattatta tctttgctga cccaaacccg ttttttactg ggtagaaagc agaattagaa 176160 taatgcctat taataaagac tagcttctgg agcagcaaat cctgggctta taaggaggct 176220 ggcagaggat caaggcattg ccctatatca tgaactgata gccctgccct ccagcatgtc 176280 tggaggactg gtgggtagag aaccaggtga aatcacaaga agcactgtca tcacacctgg 176340 gcacatacta aacaaacttt aggggcctcc tgtcaatgaa tcctctcaat agctctgcaa 176400 ggcaggtctg atttctcaca ctcgacagat gagagaaccg agaaggcact tgccccaggg 176460 tcctcagttt tgagctgcca agctgaggtt ctaacctggc tcaactccta agtttatgct 176520 ctttctacta tagggaccat ggctgccttt ggatccagcc tcggcttctc tattacctga 176580 gcaggatgag aggctgtcct cttcctcgag ctctgcttta ttcttccaga tcagggttgc 176640 cagataaaat acaggatgcc cagttacagt tgaatgtcag ataaacagca agtactattt 176700 cagcataagt cagtctcaaa tgttgcatga gacataatgt actaaaaaaa aaaatgctca 176760 ttgtttacct gaaattcaaa tttaactggg agccctgtac ttttatttac taaatctggc 176820 aactctaccc cagatgtctg tgaggttaag tggggccagg cctacagctg acggaaggac 176880 agagagagag gtggcaggga ctgctggcct cctgaggcag agctgtccca ggtctggtgg 176940 ggctatgatt ccagagaggc cagagactga gtatgaaagt ggcaggcggc tgggtctgag 177000 gagatgccaa gttggcctct tgagggaaat aaacaggtat atttagctgt tgtggccttg 177060 cgccctgagg ccaggaagca gctttttagc ctaaatccag atgttaaaaa cagaaatgaa 177120 atcagtattt atggccccaa accctccaag caagtcatgc agctcgttcc cctgtcaagg 177180 cctcccacct ttggcccaca cagggcctga ccctcgtcta agcctgcgcc ctggggaacg 177240 gaccctgggg gtggaggtgg tgggtcaggc cctgctctca ctttcacacc cgcttcctag 177300 ccctgaaacc agagaggttc ctgaagtcca gcccagccag gcctgtgggg ctgctgagag 177360 gggttaagta agagggagag taaaaaccga cacttgggag gaggctttta aaataaacat 177420 ctgcggggag ggatgctctc aaggaggctg cggtttgcag ctcagccagc tgtgttccag 177480 ctaatcagcc tccttgggct actctggagt tgctgccttg gccctgggat ggggtaggtt 177540 aagaggacag agggaggtca gggagctggg ggctgagttt ccctgagtag aggctggcac 177600 aggagagaag gcatcacccc cacctcgtcc aggccagaag atgtccagct tcttgaggct 177660 ctcctaagtc tgcctctcct gggaccaaga gaaaatcccg gtccttgacc aaggtgggcc 177720 ttggggggag tggggtgtag agggaggggc actggagaac tgactctaca gaaagtcaaa 177780 gctggcaatc caacttcttc ccctcagatt tatagatggg aaaacaggct tgagccacgc 177840 agagacttga ccaagctcac acagttcctt agtggcagag cagagcaaat attctctttc 177900 ttttacattc tggatttcca tatcttctct ccctcctggt ccagcccaac ctcagggcac 177960 cccccacgag gtgggcgggg gatggctttg tcacttgcac ccactcgggg tgctactcag 178020 agatcttggg tgcacatagg acgtgggtgg gccgagcttc tagctactcc gtcaggccct 178080 tcctgtcatt ctgtctctgc ctcccttctc cctgcttctc cgtgttcctc ctcattcttt 178140 tctgtgtgca gggagactac accccccacc ccgctctttc tctggcgcct ctgaggtccc 178200 ccctctagcc cctaaatcac tctggaatcc tggctctttg aagccagatc tgggcccccc 178260 tcccctaccc cttccattcc caggctggga aaggctgaag aggctgacgg ctggagggga 178320 gggggcgggg cggtggcgga tctggcttcc ttttggagtt aattagggaa aacagagaaa 178380 tgtcagcgga atgaaagggc tgggggtggg ggccagctgg ggtaggagag gaggaagtgg 178440 gcagctgctc cctcccactc aacccctctc ccccgccccc agaaagctct cagctccggg 178500 gatttgcgac atgaaatggg ggctgtagaa acctgagcgc tggtgcgtga agagaaaaac 178560 cgaggcgcat cccggctctc ccctcccgtg tgccctcctc ctcttatgcc ggcttgaaaa 178620 tatttcctgt ctctctattt ctcaatccct ggttgatgtc ccaggattac tcagcctctc 178680 cggctttagt cactctcgct acccgctccc agggtccagg gtggaggcag agggaggctg 178740 ggagagaagc tctactgcca gctgggcctg ggctggcctg ggcatccctg aggttttaac 178800 tgtctcctaa ccacagagga tctcagggcc tccagcagcg agccccaatg agtcaaactc 178860 ttgtttcctc ctctcccacc cccgacccag tcagggcagg tgaggggtag aggtgatggc 178920 atgctggatg tgacggtgtt gatgatgtat tgcacaggat gaagcaccat ctcatttagt 178980 cctcacagca gccttcacag tgcgtacaaa tcagctggca attccgagag gctgcattct 179040 aaacaagttc ctgggtgatg ctgagccagg gccagagtgt ggacttctct gggccccagt 179100 ttcttcttct gtacagtggg acgttggact ggaggtgctg tctgatgtca cctagctgtg 179160 gcactctgag cctgtgccta aagtgtccct gagatgtcta gtccccgaga tcatcatctc 179220 ctcagcttca tagagccgag ctcttctcca tcttctctct acctcccatt cactcagaac 179280 agggataagg tccaagctgc tggtggtgat ggtgactgac tgtcccttcc agcatgcgct 179340 taggtacact tgggcctgaa tgcccctcta acaaatgcta ccgggtatgg ccttggtcct 179400 tctaacactt ggttccctca tctgtaaaat gagggtcata ccacatagct ggctgggctg 179460 ttatgtagag gttaaaagtg attgtgcatg tgaagcatcc agcagagtgc ctggcacaca 179520 gtaggtgctc aaatgctgtt ttgaaataca aaaattagct gggctagtgg tgtgcacctg 179580 taatctcagc tactcaggag gttgaggcag gagaatcact tgagcccagg aggcagaggt 179640 tgcagtgagc cgggatcgcg ccactgcact ccaggctggg cgacagagca ggactccatc 179700 ttaaaaaaaa aaaaaaaaaa atgctgtttt gaaatggagg cttggaagag cactcttcac 179760 ccccacccca cacacttact aacggaacta ccgaatctct actcgtgcca ggccttgctt 179820 ggcaaaggct aggggcatgt aaagccatgg tttcatggct gctgccctcc aggagcccat 179880 ggtctagtgt gggagtcaga ggctcccttg agaaagccag ggcaaggaac tgagagcccg 179940 tgtcacagcc ctgagagaaa taccagcgaa tgtgttttga gcacttacat ctaccaggca 180000 ctattttacg tacctgacat acattttctt atttagcatt cactaaaacc agaagaggtg 180060 gttaccatta tcatccccat tttgcagatg agaaaactga agtggcataa ggaggttagg 180120 tagacttgcc caggatcaca gtgagtaagg aaaggagcta ggaatcaaac ctagactttc 180180 tcactccaga gcctcttaac ctctaccctc aactcttgtg aagagagact accttggtga 180240 cccctatatt cccagtgctc agcgtggtca aggcccaggg tgctgtatag gcattcatta 180300 actgctgggg atataagaca gtgactgttg aggaccctaa gtttagctcc cacctgatct 180360 tcctctgtct ctgcagaagc tgctgatggg agctccaccc tgggaggggg tgccggcacc 180420 atgggattga gcgcccgcta cggaccccag ttcaccctgc agcacgtgcc cgactaccgc 180480 cagaatgtct acatcccagg cagcaatgcc acactgacca acgcagctgg caagcgggat 180540 ggcaaggccc cagcaggtgg caatggcaac aagaagaagt cgggcaagaa ggagaagaag 180600 taacatggag gccaggccaa gagccacagg gcggcctctc cccaaccagc ccagcttctc 180660 cttacctgca cccaggcctc agagtttcag ggctaacccc cagaatactg gtaggggcca 180720 aggccatgct ccccttggga aacagaaaca agtgcccagt cagcacctac cccttccccc 180780 ccagggggtt gaatatgcaa aagcagttcc gctgggaacc cccatccaat caactgctgt 180840 acccatgggg gtagtggggt tactgtagac accaagaacc atttgccaca ccccgtttag 180900 ttacagctga actcctccat cttccaaatc aatcaggccc atccatccca tgcctccctc 180960 ctccccaccc cactccaaca gttcctcttt cccgagtaag gtggttgggg tgttgaagta 181020 ccaagtaacc tacaagcctc ctagttctga aaagttggaa gggcatcatg acctcttggc 181080 ctctcctttg attctcaatc ttcccccaaa gcatggtttg gtgccagccc cttcacctcc 181140 ttccagagcc caagatcaat gctcaagttt tggaggacat gatcaccatc cccatggtac 181200 tgatgcttgc tggatttagg gagggcattt tgctaccaag cctcttccca acgccctggg 181260 gaccagtctt ctgttttgtt tttcattgtt tgacgtttcc actgcatgcc ttgacttccc 181320 ccacctcctc ctcaaacaag agactccact gcatgttcca agacagtatg gggtggtaag 181380 ataaggaagg gaagtgtgtg gatgtggatg gtgggggcat ggacaaagct tgacacatca 181440 agttatcaag gccttggagg aggctctgta tgtcctcagg ggactgacaa catcctccag 181500 attccagcca taaaccaata actaggctgg acccttccca ctacataata gggctcagcc 181560 caggcagcca gctttgggct gagctaacag gaccaatgga ttaaactggc atttcagtcc 181620 aaggaagctc gaagcaggtt taggaccagg tccccttgag aggtcagagg ggcctctgtg 181680 ggtgctgggt actccagagg tgccactggt ggaagggtca gcggagcccc agcaggaagg 181740 gtgggccagc caggccattc ttagtccctg ggttggggag gcagggagct agggcaggga 181800 ccaaatgaac agaaagtctc agcccaggat ggggcttctt caacagggcc cctgccctcc 181860 tgaagcctca gtccttcacc ttgccaggtg ccgtttctct tccgtgaagg ccactgccca 181920 ggtccccagt gcgcccccta gtggccatag cctggttaaa gttccccagt gcctccttgt 181980 gcatagacct tcttctccca cccccttctg cccctgggtc cccggccatc cagcggggct 182040 gccagagaac cccagacctg cccttacagt agtgtagcgc cccctccctc tttcggctgg 182100 tgtagaatag ccagtagtgt agtgcggtgt gcttttacgt gatggcgggt gggcagcggg 182160 cggcgggctc cgcgcagccg tctgtccttg atctgcccgc ggcggcccgt gttgtgtttt 182220 gtgctgtgtc cacgcgctaa ggcgaccccc tcccccgtac tgacttctcc tataagcgct 182280 tctcttcgca tagtcacgta gctcccaccc caccctcttc ctgtgtctca cgcaagtttt 182340 atactctaat atttatatgg ctttttttct tcgacaaaaa aataataaaa cgtttcttct 182400 gaaaagctga a 182411 <210> 218 <211> 11915 <212> DNA <213> Homo sapiens <220> <223> C21orf57 <400> 218 gcgcgcggag ctgcgtgggg gaaggaaacg gcgcccctgg cgccggccca gcccccacgc 60 tcaccgtctc gccccaggac cccgaggccc gcgctgccca ctggcccctc ggaaagactt 120 gaggcgcaag cacaggctgc tgccgcgaca ctcagcgctg cgcaccgcgg gcagaaaacg 180 ccgcggaccg acttccggtt cgctcagcac taccggattc cgccccgccc gctgcgatcc 240 ggttccgctc cccacaaccc gctctgtggc ggggcttccg gtcgggaggg tccgcccgct 300 ctcgcgtcct ttgctgggtc cagacaccgg tacgtccggg cgggttttta gtctcccaag 360 cgagagcgtc gcattcaccc gcgtgggtct gcgggcgccc cagaccccag aggacccggc 420 ccccaacgct tacctgtccc ctctcctgtc cctcccccat tccagcccct tctctcccca 480 gccgttgccc ctccccgcac cccgccgcgt ccgcgcgcct ctctccgcgc gcacccccaa 540 cccgccccct tttctctggg aaccgctcct tccgctccgc ccgcctggag tccttctggc 600 cggattccgc ggcatccttc catagaccct cgttgttgct tcctccttgt ggtaaatgta 660 aattccctta agattttcaa tcagttccac caaataaagt gatctgattg cgcgtgcatc 720 tgtattttta cagaccgtat tatcacttgt actgattggt cttctcttac actttaaccc 780 caggttccgt tgcaaacatt tttaaagggc tggttattct tcctgaaatg agtttggtga 840 ttagaaatct gcagcgagtc atccccatca ggagagcgcc acttcgcagt aagatcgaga 900 ttgtaaggag gattttagga gtgcagaaat ttgacctggg gatcatctgt gttgacaaca 960 agaatattca gcacattaat agaatctaca gagatagaaa tgtcccaacc gatgtgcttt 1020 cttttccatt tcatgaggta aaaaaaaaat gttcctcttc ttgtctagcc catcttccca 1080 gagtaaattt cctgtcgttt tgttttgttt tgttttgttt tttaattgag acggagtctt 1140 gctctgtcac ccaggctgga gtgcagtggt gcgatctcgg ctcactgcaa cctcccttcc 1200 tggttcaagt gattcttttg cctcagcctc cccagtaggt gggaccacag atgctggcca 1260 ccacgcctgg ctaatttttt tttgtcagta tttttagtag agacgggggt tttaccatgt 1320 tggccaggct gctcctgaac tgatctcagg tgatctgcct gcctcgggct tcccagagtg 1380 ttgggattac aggcgtgagc cagagcaccc ggcctaaatt tcatgtatta attatattat 1440 aggctaggct ccatggtgcc tataagtata tatgttacag acatgatttt taattttaat 1500 tttgaaaatt ttcaaatata cacaaaagta gagagagcag tatattcagc ctccactgat 1560 cgaggcccat cacccagagt ctacaattac actggtaacc cagcaggaaa aagaaaggtg 1620 acagccgagc gcgatggctc atacccataa tcccagcact ttgggagccc gaggcgggtg 1680 gttcacctga ggtcaggagt tcgagatcag cctggccaac atggtgaaac cctgcctcta 1740 ctaaaaacac aaagaattag ctgggtgtgg ttgtgccggg cgggaggtgg aggggggcac 1800 ctataatcct agctacctgg gaggctgagg caggagaatc gcttgaaccc cagagatgga 1860 ggttgcagtg agctgagatc acaccattgc actccagcct gggcaagaag agcgaaactc 1920 tgtctcagga aaaaaaaaag aaaagaaaaa ggtgactagc gtccaccccc cttcccctcc 1980 taatgctctc agtgaattag aagagagaag caaactgctt ctgcaatatt tttgcagttt 2040 taagtgggat tcgttaatga atatgtgcac attggaaaaa ttaaaacaac actgaaaata 2100 aacagactgg ggtaaatatt tccaacaaac tcaatgtaat agcagtcagg ttattatcta 2160 cattctgtag atgacttcat tcaaggcttc ccacattgta gcagcaggaa ttggagcaat 2220 cctttgggaa agcaacttgg catttcaaac acatgtatcc tttagtcctg tggtgacaca 2280 cccaagacaa taaaccaaaa ggcagaagag gccgggtgca gtggctcacg cctgtaatcc 2340 cagcactttg ggaggccgag gtgggtggat cacgatgtca ggaattcaag accatcctgg 2400 ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa aagttagctg ggtgtggtgg 2460 catttgcctg taatcccagc tactcgggag gctgaggcag gaaaatctct tgaaccagga 2520 agtcggaggt tgcagtgagc tgagattgca ccactgcact ccagcctggc gacagagcga 2580 gactccgtct caaaaagaaa aaaaaaaaaa gaagaaaaga aaatgctgaa tcacgtaaaa 2640 atgtattgaa atgttaattt attggctggg cctataatcc cagcactttg ggaagctaag 2700 gtgggaggat cacttgagcc caggagttca agaccagtct gggcaacatg gtcaaacctt 2760 gtttctacaa aaaataaaaa caacaattag ccgggcatgg tggtgtgcag agctgtcgtc 2820 ccagctactc aggaggctaa ggtgagagga tcgcctgagc tcaagaaact gaggctgcag 2880 tgagccaaga ctgcacctct gcactccacc ctgggccaca gagtaacacc ctttttcaaa 2940 aaaaaagtta ccattttctg taataggaaa ataagaggag catcctaaat atccagccat 3000 aggtgactgg cttagtgtga acagtcctta actaagtgga ctggtcttta tagtctttat 3060 gtggaaaatg tgaaagactc tttaggacaa aataccaagt ggaaagaaca ggaatataca 3120 gtcgtgtcca tgtgatgatt taactctgta gaagttgtgg atctgcgtga ttctgcattg 3180 ggagggatga aagaaatgaa aagccatttg acaaggtgat agcaacctaa acaaacaggc 3240 ttttaaagaa aaggatgttt atttgggata gagcattgca gtgaaaatac atgccacatg 3300 ccatagtaga ctgtgtggat attcgcatat tcagggaggt aaaggaaggc aagggttttg 3360 tttttttttt tttttttgag acggaggctt gctctgtcac ccaggctgga gtgcaatggc 3420 acaatctcgg ctcactgcaa cctccacctc tcaggtccaa gcgattctcc tgcttcagcc 3480 tcccgagtag ctgggattac aggcgcccac caccacatct ggctaatttt tttttttttg 3540 tatttttagt aaagttgggg tttcaccatg ttggccaagc tggtctagaa ctcctgacct 3600 caggtgatct acccgcctct gccttccaaa gtgctgggat tacaggcgtg agccactgag 3660 ccccgcctgg caaaggtttt taaaggaaaa aaacataatt gttttgagat aatgatcctt 3720 ggttgcaaag atcaataaca agattaatgt ccgtccaagg ttagacaggc agttgctggg 3780 cagattatcc ttgcagaagt ttctgtgtgc gtgtaaggtt gtcatagcct ttgtgcaagg 3840 ttgcagtttt gtgtgtgtgt aaggttgtca tagcctttgt gcaaggttgc agtttcgtgt 3900 gtgtgtgtaa ggttgtcata gcctttgtgc aaggttgcag ttttgtatgt gtgtaaggtt 3960 gtcatagcct ttgttgcagt ttttgccatc tttagtgaca gtttttgtta tcaggcatgg 4020 aagtatgaga atcctctctt catagctttc cccagctcta tttgtcaggt tttttggttt 4080 gtttgtataa ccctaatggc tccattttta ttctgacaaa ttcctttttt tttttgagac 4140 ggagtcttgc tctgtcagcc aggctgaagt gcaatggcgc agtctagggg ctcactgcaa 4200 cctccgcctc ccaggttcaa gcgattctcc tgcctcagcc tcccgagtag ctggggttac 4260 aggcatgtgc catcacacct ggctaatttt tgtattttta gtagagatgg ggtttcacca 4320 tgttggtcag gctggtgtca aacccctgac ctcttgatct gcccgcctcg gcctcccaaa 4380 gtgctgggat tacagctgtg agccaccacg cctggctatt ctgacaattt tcacaatgga 4440 aacaatttag ggcacttgtg tacggttggc tgggcaaccc acccgccaca ggcccagctg 4500 ccactctggc ctgagacatg catcttaaga gtgatttggg tggctggcac agtggctcac 4560 gcctgtaatc ccagcactct gggaggctga ggcaggcaga tcacctgagg tcaggagttc 4620 gagaccagcc tgacccatat gatgaaaccc catctctact aaaaaataca aaaattaggc 4680 cagacgcggt ggctcacgcc tgtaatccca gcactttcgg aggccaaggc gggtggatca 4740 cctgaggttg ggagtttgag accagcctga ccaacacgga gaaacccagt ctctactaaa 4800 aatacaaaat tagccgggcg tggtggcgca tgcctgtagt cccagctact cgggaggctg 4860 aggcaggaga attgcttgaa cccaggaggc ggacactcca gcctgggcaa caagagggaa 4920 actctgtctc aggaaaaaaa aaaaaaaaag aaatacaaaa attagctggg cacggtggca 4980 tgcacctgta atcccagcta ctcaggaggc tgagacagga gaatcacttg aacccgggag 5040 gcagaggttg cagtgagccg agatcgcgcc attccactgc agcctgggca acaagagtga 5100 aactccgtct caaaaaaaaa aaaaaaaaaa gtgatttggc tcagagataa gtgcttattt 5160 gccttgggat taaccaggat gaaacctgtc aacctgtggt tgggttacgt ttcctgttct 5220 ctaagtctac atttcctcat tttttagcat ctgaaagcag gtgaatttcc ccagcctgat 5280 tttccagatg actacaattt gggagacatt ttcctaggag tggagtatat cttccatcag 5340 tgtaaagaaa atgaagatta caatgacgtc ctgactgtaa gcggggatgc tgaaatcata 5400 taacctggct catggaacat gggccttgca aaggggtcaa gatcacaacc ctgcatccat 5460 gtgtgtccgt gggtaccgta agggctactg ggggaagaac ctgtaagcag ggtgtgagga 5520 gcacccaggc tgggtaggga ctgcatgccc catgccacag ttgaaggagg gagagaacac 5580 gctgtgaaaa cacagaagct cccagagaag ccttctcagc ttttatctct ggagtagagc 5640 agactatgtt gagctaacac agacctgctg aatcagcttc tttctgagct gccagaagta 5700 cagaagttgg agcctccacc accttccaga tctgtttctc ctcagtgtaa tccacctatg 5760 ggttcttcct gcccactgca cagacaaaac caattcactg caattgtggt attgcagtag 5820 agaaagagtt taacacagag ctagccaagc agaaaggctg gagttattat tcaactcaat 5880 ctcccagaga actcagaggc tacagtttct acaggcaatt tggcaggcag gggctaggga 5940 atgcctgctg ctgatcggct gcagacggac catggggtgt caacgatttt tgtcccctga 6000 gtccgcctct gcgtggagcc acgggatcag ctgagtcatg agtctcaggt ccaggtggag 6060 tctgtaggtt gccagaactc aaaagtctga aaaacatccc aaaagaccat tcttaggttg 6120 tactattgac gttatcttat tggggagcaa ttggggcggt cacaaatctc gtgacctctg 6180 gctgcgtgag tcctgagcag tagggaatta cagcagggca agctggggaa gcaaggcctg 6240 cgggctggtt ctcctcagga cacctacatc tgagcagaat tcaggcccct cccatcatcc 6300 taatcttgtg gcccttcaca agcttcacag aggtggcttc ggtcttgagc aaggagggga 6360 ttcgttttag ggagggatga ttactattct tgatttaaag ttaaactcta gattaaattc 6420 ctcccgtggt tagcttggcc tgtgcccggg actgagtggg gacagccacg caagttaaac 6480 tctagattaa attcctcccg cggttagcct gacccgtgcc cgggactcag tggggacagc 6540 cacgcaagtt aaactctaga ttaaattcct cccgcggtta gcctgacccg tgcccgggac 6600 tcagtgggga cagccacgca agttagactc tagattaaat tcctcccgcg gttagcctga 6660 cccgtgcccg ggactcagtg gagtcagcca cacaagttaa actctagatt aaattcctcc 6720 cgcggttagc ctgacccgtg cccgggactc agtggagtca gccacgcaag ttaaactcta 6780 gattaaattc ctcccgcggt tagcctgacc cgtgcccggg actcagtggg gacagccaca 6840 caagttagac tctagattaa attcctcccg cggttagcct gacccgtgcc cgggactcag 6900 tggggacagc cacacaagtt aaactctaga ttaaattcct cccgcggtta gcctgacctg 6960 tgcccgggac tcagtgggga cagccacgca agttaaactc tagattaaat tcctcccgcg 7020 gttagcctga cccgtgcccg ggactcagtg gagtcagcca cacaagttaa actctagatt 7080 aaattcctcc cgcggttagc ctgacccgtg cccgggactc agtggggaca gccacgcaag 7140 ttaaactcta gattaaattc ctcccgcggt tagcctgacc cgtgcccggg actcagtggg 7200 gacagccaca caagttaaac tctagattaa attcctcccg cggttagcct gacccgtgcc 7260 cgggactcag tggagtcagc cacgcaagtt agactctaga ttaaattcct cccgcggtta 7320 gcctgacccg tgcccgggac tcagtggagt cagccacaca agttagactc tagattaaat 7380 tcctcccgcg gttagcctga cccgtgcccg ggactcagtg gggacagcca cacaagttag 7440 actctagatt aaattcctcc cgcggttagc ctgacccgtg cccgggactc agtggagtca 7500 gccacgcaag ttagactcta gattaaattc ctcccgcggt tagcctgacc cgtgcccggg 7560 actcagtggg gacagccacg caagttagac tctagattaa attcctcccg cggttagcct 7620 gacccgtgcc cgggactcag tggagtcagc cacgcaagtt agactctaga ttaaattcct 7680 cccgcggtta gcctgaccca tgcccgggac tcagtgggga cagccacgca agttagactc 7740 tagattaaat tcctcccgcg gttagcctga cccgtgcccg ggactcagtg gggacagcca 7800 cacaagttag actctagatt aaattcctcc cgcggttagc ctgacccgtg cccgggactc 7860 agtggagtca gccacgcaag ttagactcta gattaaattc ctcccgcggt tagcctgacc 7920 cgtgcccggg actcagtgga gtcagccaca caagttagac tctagattaa attcctcccg 7980 cggttagcct gacccgtgcc cgggactcag tggagtcagc cacacaagtt aaactctaga 8040 ttaaattcct cccgcggtta gcctgacctg tgcccgggac tcagtggagt cagccacaca 8100 agttaaactc tagattaaat tcctcccgcg gttagcctga cccgtgcccg ggactcagtg 8160 gagtcagcca cgcaagttag actctagatt aaattcctcc cgcggttagc ctgacccgtg 8220 cccgggactc agtggagtca gccacgcaag ttaaactcta gattaaattc ctcccgcggt 8280 tagcctgacc cgtgcccggg actcagtggg gacagccaca caagttaaac tctagattaa 8340 attcctcccg cggttagcct gacccgtgcc cgggactcag tggggacagc cacgcaagtt 8400 agactctaga ttaaattcct cccgcggtta gcctgacccg tgcccgggac tcagtggagt 8460 cagccacaca agttaaactc tagattaaat tcctcccgcg gttagcctga cccgtgcccg 8520 ggactcagtg gggacagcca cgcaagttag actctagatt aaattcctcc cgcggttagc 8580 ctgacccgtg cccgggactc agtggagtca gccaccccag acctctctca ctgttatcat 8640 ttttgcacag gtggtttcag cagcttgatg ccaaaaaaaa aaaaaaaaaa ggaaaagcat 8700 tctgaaaagc catgtatgag tgaatcatac ttaacttggc ctcctttggc tgcacagcca 8760 tgccctgaat cgcccttgtg gatccaagtg catctgtgtg gcttgaggca gagcttccca 8820 gccagaccca gtgtgaaagg atgggacggc cacacaggaa cctgggcccc aactgctccc 8880 tccagacctg ggtgggactt gcccgccatg cacaccctgc tggggaagag ggagtttctg 8940 agagtgacag gaagtggccc agccggagat tcagccctgg gatctctgtg gccagcaact 9000 gtgggcgggg gggtatgtgg acatctgctt ccattttccc caaacctaag attctgttcc 9060 ctggtcttcc cctggcattt cttcctcggg cccagagccc tctccttggg gctccctatt 9120 accctgaggg gagggccagc ccaccagccc aggaccccat cctcatagcc acaggccagg 9180 ccagctctgc tcagggctgg ctctcagctg cactctccat ctaccctgcc ttgtcctcca 9240 tgtctccagg cacctcccgc cagccccaag gatacccacc tcccagacct ccctcttccc 9300 tccacccaaa ccccagggga gtgctacccc tatggcccat gtggctccat aaaccccctt 9360 ggtgctgtgc ctgctcaggg tccacaggcc ctccctcctc ttcctcctcc tcctcctctt 9420 cccccagctc tgggctccat ccgggtgccc ctcccctgtg ggctttaatc cagccctctc 9480 tccaggggga catggcgact gtgggtcttc ctgactcacc agcagctgca cctccctccg 9540 cctccgcctt catacctctc ccgcactccc tgtgctgcct gtgccccaaa gctctaccca 9600 gagtgttcag taaaatcagg ggccaccgga ggccccatcc tgactggggg ttggacctgg 9660 ggtgtgggct gtgcgcttgc ctcgtccctc ttagggcagg gaggccaccc ctggccggtg 9720 ccccactgcc ccaccacccc gtggcaccca cccctcccca cttcttcata ttccatcccc 9780 ccttgcccat tgctcctgcg gctgggcagt tccatcctgg gggcccctcc ccagcacagt 9840 gctggcccag acagcaatcc acgttgacta aagactctca aaggggcttg cttgctttcc 9900 attttagatg gaagggaact gaagctgagt gcctgtaatt cctgcccagg ggtctcacag 9960 caaccctggg gtcctgcagc cacataccaa gagcagcctg tggccctggg gtggccctga 10020 aggggcaggt tcctgtgggg tcatcctctg agccggttta aaattattct gacaggtgac 10080 ggccacccac ggactctgtc acttgctggg attcacacac ggcacggagg cagagtggca 10140 gcaggtaagg agcccatcca tcccactacc gagggggtgc gtgggggaag gaggctcccc 10200 caggcccctg ccagccccca ccctccatct tgaccgcccc cgcaggaact ggacctcaga 10260 cctgcccttg taaaaatgac acagatgttt gctttcaaca ccgggctccc caaatacttc 10320 cagctgaatg tgttcactaa ggaaagcggt ctgagtgcag aggccgagag ccacagctga 10380 cactagcacg tggcgcttgg tcaaaaaggt ccaatcagct agagactagg ccagacccag 10440 ggcggaggcg ggagctctgc gtggagtgag ttccgggttg gtttcctcca gacccatgcg 10500 ctccgcctac ggaggcccac gtgggctccg gtccacatgg ttaacacgca cgcaagcccg 10560 tgttgggagc aaactgcttc tctgaaagtc atgaaaaacc tttttcatta aaaaaagaaa 10620 aagtttggcc gggcgcagtg gctcacgcct gtaatcccag cactttggga ggccgaggca 10680 ggcggatcaa ctgaggttgg gagttcgcga ccagcctggc caacatggag aaaccctgtc 10740 tctactaaaa atacaaaatt agctgggcct ggtggtgcat gcctgtaatc ccagctactc 10800 aggaggctga ggcaggagaa tcgcttgaac ccaggaggcg gaggttgtgg ttagccgaga 10860 gatcgcgtca ttgcactcca gcctgggcaa caagagtgaa agtccgtctc aaaaagaaaa 10920 agaaaaagtt ggccaggcgc agtggctcac gcctgtaatc ccagcacttt gggaggccga 10980 ggagggtgga tcacttgagg tcaggagttc aagaccagtc tggccaacat ggtgaaaccc 11040 ggtctctact aaaaacgcaa agattagccg ggcgtggtgg tgggcgcctg taatcccagc 11100 tacaggggag gctgaggcag gagaatcgct tgaacccggg aggtggaggt tgcagtgagc 11160 cctcctcccc tcctccccct tcccttccca cctcccatgc ccccctttct tcctcccact 11220 cccctcccga ggccccgctt attctcccgg cctgtggcgg ttcgtgcact cgctgagctc 11280 aggttctggt gaaggtgccc ggagccgggt cccgccttcg gcctgagcta gagccgcgcg 11340 ggcggccggc ttcccccaaa ccctgtggga ggggcatccc gaggaggcga ccccagagag 11400 tggggcgcgg acaccttccc tggggagggc cagcgcgctt ccttccttcc agatgttcca 11460 gaaggagaag gcggtgctgg acgagctggg ccgacgcacg gggacccggc tgcagcccct 11520 gacccggggc ctcttcggag ggagctgagg gccgcgttcc ttctgaaagc gggacgcggg 11580 aggggtggag gctgcgggga gccggggtcg cacacgaata aataacgaat gaacgtacga 11640 ggggaacctc ctcttatttc cttcacgttg catcgggtat ttttcgttat tgtaaataaa 11700 acggttccga gccgtggcat cgagagggcg tctggagttc agggaacgcg tggcccccgc 11760 ccgggagcac cgcgcagcgc tcgcctctcg cccttcaagg gggtccctgc ccggagcctg 11820 cgcccccgga gaggaagggg ctcgaggggc ttgggtgccg cagcgcgtcc ttccgtagaa 11880 aaggcttgcg tcagtatttc ctgcttttac ctcct 11915 <210> 219 <211> 93 <212> DNA <213> Homo sapiens <220> <223> C21orf57 DMR <400> 219 cgagccgtgg catcgagagg gcgtctggag ttcagggaac gcgtggcccc cgcccgggag 60 caccgcgcag cgctcgcctc tcgcccttca agg 93 <210> 220 <211> 95 <212> DNA <213> Homo sapiens <220> <223> PCDHGA1 DMR <400> 220 agcgactgcc gctctaagtg ccgggcgggc aggactctac gatccttggg ccagaggtcc 60 ggatggtccc gggactccgt ctcaagggtc ggcga 95 <210> 221 <211> 92 <212> DNA <213> Homo sapiens <220> <223> PCDHGA1 OR <400> 221 gcgatctagg gtcagagatt tggaggtgac caaactatct gacactctaa caagtcctgt 60 ctcctctggc agatggaaag ctataggctc tg 92 <210> 222 <211> 16 <212> DNA <213> Artificial Sequence <220> <223> Primer Chr21DMR2-For <400> 222 cgagccgtgg catcga 16 <210> 223 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> Primer Chr21DMR2-Rev <400> 223 ccttgaaggg cgagagg 17 <210> 224 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Chr21DMR2-Probe <400> 224 cgttccctga actccagacg c 21 <210> 225 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> Primer Chr5DMR-For <400> 225 agcgactgcc gctctaa 17 <210> 226 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> Primer Chr5DMR-Rev <400> 226 tcgccgaccc ttgagac 17 <210> 227 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Chr5DMR-Probe <400> 227 tctggcccaa ggatcgtaga gtcc 24 <210> 228 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Primer Chr5OR-For <400> 228 gcgatctagg gtcagagatt tg 22 <210> 229 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> Primer Chr5OR-Rev <400> 229 cagagcctat agctttccat ctg 23 <210> 230 <211> 28 <212> DNA <213> Artificial Sequence <220> <223> Chr5OR-Probe <400> 230 acactctaac aagtcctgtc tcctctgg 28 <210> 231 <211> 105 <212> DNA <213> Homo sapiens <220> <223> C21orf29 <400> 231 acttgaatag ccaaatgagt cctagaaagc gagagacgag aggggaatga gcgccgaaaa 60 tcaaagcagg ttcccctcct gacaactcca gagaaggcgc atggg 105 <210> 232 <211> 81 <212> DNA <213> Homo sapiens <220> <223> CGI149 <400> 232 cgtccggtga gcctaagacg cgcctttgcc ggggttgccg ggtgtctgcc tctcacttag 60 gtattaggaa ccgtggcaca a 81 <210> 233 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> Primer Chr21DMR3-For <400> 233 acttgaatag ccaaatgagt cct 23 <210> 234 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> Chr21-DMR3-Rev <400> 234 cccatgcgcc ttctctg 17 <210> 235 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> Probe Chr21DMR3 <400> 235 tcccctctcg tctctcgctt tct 23 <210> 236 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Primer Chr21DMR4-For <400> 236 cgtccggtga gcctaaga 18 <210> 237 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Primer Chr21DMR4-Rev <400> 237 ttgtgccacg gttcctaata c 21 <210> 238 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Probe Chr21DMR4 <400> 238 ccgggtgtct gcctctcact ta 22 <210> 239 <211> 106 <212> DNA <213> Homo sapiens <400> 239 cctgggctgt gtctggtccc ggccacgcgt ccctgcagcg tctgagacct tgtggaacac 60 acttgacccg gcgctgggac ggggtcggcc cacacgcacc gccagc 106 <210> 240 <211> 111 <212> DNA <213> Homo sapiens <400> 240 gccccagagc ctcctttcgg ggcgcgaggc ccggcgcgtg tgtacggagt ccagtccccc 60 cagggagtgg ggtgcccgca ccttcttcct ccgcgctcgg agccacaggg g 111 <210> 241 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Primer Chr18DMR1-For <400> 241 cctgggctgt gtctggtcc 19 <210> 242 <211> 16 <212> DNA <213> Artificial Sequence <220> <223> Primer Chr18DMR1-Rev <400> 242 gctggcggtg cgtgtg 16 <210> 243 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> Probe Chr18DMR1 <400> 243 tggaacacac ttgacccggc gct 23 <210> 244 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Primer Chr18DMR2-For <400> 244 gccccagagc ctcctttcg 19 <210> 245 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> Primer Chr18DMR2-Rev <400> 245 cccctgtggc tccgagc 17 <210> 246 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Probe Chr18DMR2 <400> 246 tgcgggcacc ccactccctg 20

Claims (66)

  1. 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법으로서,
    (a) 모체에서 유래한 상이하게 메틸화된 DNA와 혼합된, 태아의 세포 및/또는 태아의 태반으로부터 유래된 DNA를 포함하는, 상기 임신여성으로부터 채취한 시료를 제공하는 단계;
    (b) 메틸화 및 비메틸화 DNA를 상이하게 변형시키는 시약으로 상기 시료에 존재하는 DNA를 처리하는 단계;
    (c) 상기 시료에서 염색체 이수성과 관련된 염색체인 제1 표적 DNA 종의 양을 결정하되, 상기 염색체에 위치하는 둘 이상의 제1 표적의 상이한 메틸화 영역(제1 표적 DMR)에 메틸화가 존재하는지를 상기 시료에서 검출함으로써 결정 ― 여기서, 상기 제1 표적 DMR은 태아의 세포 및/또는 태아의 태반에서 유래한 DNA와 모체 유래 DNA 간에 상이하게 메틸화된 영역이고, 제1 표적 DMR의 DNA의 상기 시약에 의한 변형은 DNA의 메틸화에 감응하고, 상기 제1 표적 DMR 중 하나 이상에서의 메틸화 DNA의 검출량은 상기 시료 내의 상기 제1 표적 DNA 종의 양을 나타냄 ― 하는 단계;
    (d) 상기 시료에서 하나 이상의 기준 염색체인 기준 DNA 종의 양을 결정하되, 상기 기준 염색체(들)에 위치하는 둘 이상의 기준 DMR에 메틸화가 존재하는지를 상기 시료에서 검출함으로써 결정 ― 여기서, 상기 기준 DMR은 태아의 세포 및/또는 태아의 태반에서 유래한 DNA와 모체 유래 DNA 간에 상이하게 메틸화된 영역이고, 상기 기준 DMR의 DNA의 상기 시약에 의한 변형은 DNA의 메틸화에 감응하고, 상기 기준 DMR 중 하나 이상에서의 메틸화 DNA의 검출량은 상기 시료 내의 상기 기준 DNA 종의 양을 나타냄 ― 하는 단계;
    (e) 단계 (c)에서 결정된 양과 단계 (d)에서 결정된 양의 상대적 양(들), 바람직하게는 비율(들)을 결정 ― 여기서, 상기 하나 이상의 상대적 양(들)은 태아 내의 염색체 이수성의 존재 또는 부존재를 지시함 ― 하는 단계를 포함하되,
    상기 단계 (c) 및 단계 (d)에서의 상기 검출은 상기 시료의 동일한 DNA 분취량(aliquot)을 사용하여, 그리고 동일 용기에서, 그리고 상기 제1 표적 DMR 및 상기 기준 DMR에 대해 유효하게 동시에 수행되며, 그리고 (x) 상기 기준 DMR의 적어도 두 개에 대해 동일한 검출 표지(들)를 사용하여서 그리고/또는 (y) 상기 제1 표적 DMR의 적어도 두 개에 대해 상이한 검출 표지(들)를 사용하여서 수행되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  2. 제1항에 있어서, 상기 단계 (e)에서, 상기 상대적 양(들) 또는 비율(들)을 임계값 및/또는 기준 분포와 비교하되, 여기서 하나 이상의 상기 상대적 양(들) 또는 비율(들)이 상기 임계값 및/또는 기준 분포보다 높거나 낮음은 태아 내의 염색체 이수성의 존재를 지시하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  3. 제1항 또는 제2항에 있어서, 상기 기준 DMR 중 2개 이상은 상이한 기준 염색체에 위치하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  4. 제1항 내지 제3항 중 어느 한 항에 있어서,
    (f) 상기 시료에서 총 DNA의 양을 결정하되, 태아의 세포 및/또는 태아의 태반으로부터 유래한 DNA와 모체 유래 DNA 간에 상이하게 메틸화되지 않은 적어도 하나의 타영역(OR)을 검출함으로써 결정 ― 여기서 상기 시약에 의한 OR(들)의 변형은 DNA 메틸화에 감응성이 없음 ― 하는 단계를 추가로 포함하되,
    여기서 상기 단계 (c) 및 단계 (d) 및 단계 (f)에서의 상기 검출은 상기 시료의 동일한 분취량의 DNA를 사용하여 그리고 동일한 용기에서, 그리고 효율적으로는 상기 기준 DMR 및 상기 타영역에 대하여 동시에 이루어지며, 그리고 (x) 상기 기준 DMR의 적어도 2개 이상에 대해 동일한 검출 표지(들)가 사용되고, (y) 상기 제1 표적 DMR의 적어도 두 개에 대해 그리고 상기 OR의 적어도 하나에 대해 상이한 검출 표지(들)가 사용되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  5. 제4항에 있어서, 상기 OR은 하나 이상의 기준 염색체에 위치하되, 바람직하게는 상기 기준 DMR의 적어도 하나와 동일한 기준 염색체에 위치하는 상기 OR의 적어도 하나에 위치하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  6. 제1항 내지 제5항 중 어느 한 항에 있어서,
    (c)' 상기 시료에서 다른 염색체 이수성과 관련된 염색체인 제2 표적 DNA 종의 양을 결정하되, 상기 다른 염색체 이수성에 관련된 염색체에 위치하는 둘 이상의 제2 표적 DMR에 메틸화가 존재하는지를 상기 시료에서 검출함으로써 결정 ― 여기서, 상기 제2 표적 DMR은 태아의 세포 및/또는 태아의 태반에서 유래한 DNA와 모체 유래 DNA 간에 상이하게 메틸화되고, 상기 제2 표적 DMR의 DNA의 상기 시약에 의한 변형은 DNA의 메틸화에 감응하며, 상기 제2 표적 DMR 중 하나 이상에서 메틸화된 DNA의 검출량은 상기 시료 내의 상기 제2 표적 DNA 종의 양을 나타냄 ― 하는 단계;
    (e)' 단계 (c)'에서 결정된 양과 단계 (d)에서 결정된 양의 상대적 양(들), 바람직하게는 비율(들)을 결정 ― 여기서, 상기 상대적 양(들)의 하나 이상은 태아 내의 다른 염색체 이수성의 존재 또는 부존재를 지시함 ― 하는 단계를 포함하되,
    상기 단계 (c) 및 단계 (c)' 및 단계 (d) 및 선택 단계 (f)에서의 상기 검출은 상기 시료의 DNA의 동일 분취량을 사용하여, 그리고 동일 용기에서, 그리고 상기 제1 표적 DMR 및 제2 표적 DMR 그리고 상기 기준 DMR에 대해 유효하게 동시에 수행되며, 그리고 (x) 적어도 두 개의 상기 기준 DMR에 대해 동일한 검출 표지(들)가 사용되고, (y) 적어도 두 개의 상기 제1 표적 DMR 및 적어도 두 개의 상기 제2 표적 DMR에 대해 그리고 선택적 OR(들)에 대해 상이한 검출 표지가 사용되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  7. 제6항에 있어서, 상기 단계 (e)'에서, 상기 상대적 양(들) 또는 비율(들)을 임계값 및/또는 기준 분포와 비교하되, 여기서 하나 이상의 상기 상대적 양(들) 또는 비율(들)이 상기 임계값 및/또는 기준 분포보다 높거나 낮음은 태아 내의 다른 염색체 이수성의 존재를 지시하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  8. 제1항 내지 제7항 중 어느 한 항에 있어서, 상기 단계 (c) 및/또는 단계 (d), 및/또는 선택적 임의 단계 (c)' 및/또는 선택적 임의 단계 (f)에서의 상기 검출 전에 또는 검출의 일부로서, 상기 DMR 및/또는 상기 옵션으로 사용된 OR(들)을 포함하는 각각의 DNA 영역이 증폭되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  9. 제1항 내지 제8항 중 어느 한 항에 있어서, 단계 (c) 및/또는 단계 (d), 및/또는 선택적 임의 단계 (c)' 및/또는 선택적 임의 단계 (f)에서 사용되는 각 검출 표지는 형광, 단백질, 소분자, 또는 방사성 표지로 구성되는 군으로부터 독립적으로 선택되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  10. 제1항 내지 제9항 중 어느 한 항에 있어서, 단계 (c) 및/또는 선택적 임의 단계 (c)'에서의 상기 검출은 상기 제1 표적 DMR 중 하나, 및/또는 선택적 제2 표적 DMR 중 하나에 대해 적어도 하나의 표지처리된 프로브를 사용하는 실시간 정량화 PCR을 포함하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  11. 제1항 내지 제10항 중 어느 한 항에 있어서, 단계 (d)에서의 상기 검출은 상기 기준 DMR 중 하나에 대해 각각 특화된 적어도 2개의 표지처리된 프로브를 사용하는 다중형 실시간 프로브 기반의 정량적 프로브 기반 PCR을 포함하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  12. 이전 청구항들 중 어느 한 항에 있어서 제4항에 종속되는 경우에, 단계 (f)에서의 상기 검출은 상기 OR(들) 중 하나에 특화된 적어도 하나의 표지처리된 프로브를 사용하는 실시간 정량화 PCR을 포함하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  13. 이전 청구항들 중 어느 한 항에 있어서 제4항에 종속되는 경우에, 상기 OR은 상기 기준 DMR 중 적어도 하나의 상류 또는 하류로 약 20bp 내지 20kb 사이에, 그리고/또는 상기 상기 기준 DMR 중 적어도 하나와 동일한 유전자 내에 위치하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  14. 이전 청구항들 중 어느 한 항에 있어서 제4항에 종속되는 경우에, 단계 (f)에서의 상기 검출은 상기 OR들의 적어도 2개를 이용하는 것을 포함하되, 여기서, 바람직하게는, 상기 OR의 수는 단계 (d)에서 사용된 기준 DMR의 수와 동일하고, 보다 바람직하게는, 상기 OR들 중 하나는 단계 (d)에서 사용된 기준 DMR과 동일한 염색체에(특히, 이 기준 DMR의 상류 또는 하류로 약 20bp 내지 약 20kb 사이에) 위치하며, 상기 각각의 OR은 상기 기준 DMR 중의 다른 하나와 동일한 염색체에(특히, 이 기준 DMR의 상류 또는 하류로 약 20bp 내지 약 20kb 사이에) 위치하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  15. 제14항에 있어서, 단계 (f)에서의 상기 검출은 (x) 상기 OR 각각에 대해 동일한 검출 표지(들)를 사용하여 수행되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  16. 제14항 또는 제15항에 있어서, 단계 (f)에서의 상기 검출은 상기 OR 중 하나에 특화된 적어도 하나의 표지처리된 프로브를 사용하는 다중형 실시간 정량화 프로브 기반 PCR을 포함하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  17. 제1항 내지 제16항 중 어느 한 항에 있어서, 상기 검출 단계 (c) 및 단계 (d), 및 선택적 임의 단계 (c)' 및 선택적 임의 단계 (f)는 상기 시료의 DNA의 동일 분취량을 사용하여 그리고 동일한 반응/검출 용기에서, 그리고 유효하게 서로 동시에, 그리고 상기 DMR 및 옵션으로 사용된 OR(들) 각각에 특화된 적어도 하나의 표지처리된 프로브를 사용하는 다중형 실시간 정량화 프로브 기반 PCR에 의해 수행되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  18. 제1항 내지 제17항 중 어느 한 항에 있어서, 상기 시료는 전혈, 부분혈, 소변, 타액, 땀, 눈물, 가래, 젖, 유방 흡인물, 질 분비물, 질 세척물, 및 결장 세척물 중의 군에서 선택된 생물학적 유체이며, 보다 바람직하게는 혈장 또는 혈청 시료인, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  19. 제1항 내지 제18항 중 어느 한 항에 있어서, 태아의 세포 및/또는 태아의 태반으로부터 유래된 상기 DNA 종은 순환 무세포 DNA이고, 상기 시료는 혈장 또는 혈장과 같은 부분혈인, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  20. 제1항 내지 제19항 중 어느 한 항에 있어서, 메틸화 및 비메틸화 DNA를 상이하게 변형시키는 상기 시약은 바이설파이트를 포함하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  21. 제1항 내지 제19항 중 어느 한 항에 있어서, 메틸화 및 비메틸화 DNA를 상이하게 변형시키는 상기 시약은 메틸화 DNA보다 비메틸화 DNA를 선택적으로 분해(digest)시키는 제제를 포함하되, 이 제제는,
    - 적어도 하나의 메틸화 감응성 효소.
    - 적어도 하나의 메틸화 감응성 제한효소. 및/또는
    - AatII, AciI, AclI, AfeI, AgeI, AgeI-HF, AscI, AsiSI, AvaI, BceAI, BmgBI, BsaAI, BsaHI, BsiEI, BsiWI, BsmBI, BspDI, BsrFI, BssHII, BstBI, BstUI, ClaI, EagI, FauI, FseI, FspI, HaeII, HgaI, HhaI, HinPlI, HpaI, Hpy99I, HpyCH4IV, KasI, MluI, NaeI, NarI, NgoMIV, NotI, NotI-HF, NruI, Nt.BsmAI, Nt.CviPII, PaeR7I, PluTI, PmlI, PvuI, PvuI-HF, RsrII, SacII, SalI, SalI-HF, SfoI, SgrAI, SmaI, SnaBI, TspMI, 및 ZraI로 이루어진 군에서 선택된 제제를 포함하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  22. 제1항 내지 제21항 중 어느 한 항에 있어서, 상기 염색체 이수성에 관련된 상기 염색체는 21번 염색체, 18번 염색체, 13번 염색체, X 염색체, 및 Y 염색체로 이루어진 군으로부터 선택되는 인간 염색체, 바람직하게는 21번 염색체, 18번 염색체, 13번 염색체로 이루어진 군으로부터 선택되는 인간 염색체, 가장 바람직하게는 인간의 21번 염색체를 포함하고; 상기 염색체 이수성은 상기 염색체의 이수성, 바람직하게는 상기 염색체의 삼염색체인, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  23. 제22항에 있어서 제6항의 경우에, 다른 염색체 이수성에 관련된 상기 염색체는 21번 염색체, 18번 염색체, 13번 염색체, X 염색체 및 Y 염색체로 이루어진 목록으로부터 선택된 다른 인간 염색체, 바람직하게는 18번 염색체 또는 13번 염색체, 가장 바람직하게는 18번 염색체를 포함하고; 상기 다른 염색체 이수성은 상기 다른 염색체의 이수성, 바람직하게는 상기 다른 염색체의 삼염색체인, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  24. 제23항에 있어서, 상기 염색체 이수성에 관련된 상기 염색체 및 상기 다른 염색체 이수성에 관련된 상기 다른 염색체는 염색체 21번 및 18번, 염색체 21번 및 13번, 염색체 18번 및 13번으로 이루어진 목록 중에서 선택되고; 상기 염색체 이수성 및 상기 다른 염색체 이수성은 각각의 염색체의 이수성, 바람직하게는 각각의 염색체의 삼염색체인, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  25. 제1항 내지 제24항 중 어느 한 항에 있어서, 각각의 기준 염색체는 염색체 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12번, 염색체 14, 15, 16, 17번, 염색체 19번, 염색체 20번, 염색체 22번, 및 염색체 23번으로 이루어진 목록으로부터 독립적으로 선택된 인간 염색체, 바람직하게는 염색체 5번 또는 염색체 12번의 인간 염색체인, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  26. 제25항에 있어서, 하나의 기준 DMR은 인간 염색체 5번에 위치하고 또 다른 기준 DMR은 인간 염색체 12번에 위치하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  27. 제26항에 있어서, 상기 제1 표적 DMR의 각각은 인간 염색체 21번, 염색체 18번, 또는 염색체 13번에, 바람직하게는 염색체 21번에 위치하고; 선택사항으로 상기 제2 표적 DMR의 각각은 인간 염색체 18번 또는 인간 염색체 13번에 위치하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  28. 제1항 내지 제27항 중 어느 한 항에 있어서, 상기 DMR은 태아 DNA에서 과다 메틸화되고 모체 DNA에서 저도 메틸화되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  29. 제1항 내지 제28항 중 어느 한 항에 있어서, 상기 DMR은 상기 시약에 특이적인 적어도 하나의, 바람직하게는 적어도 둘의 메틸화 부위를 포함하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  30. 제1항 내지 제29항 중 어느 한 항에 있어서, 상기 제1 표적 DMR 및/또는 상기 선택적인 제2 표적 DMR은 각각,
    - WO 2011/092592의 EP1, EP2, EP3, EP4, EP5, EP6, EP7, EP8, EP9, EP10, EP11, 및 EP12(서열번호 33~44)로 이루어진 목록 중에서 선택된 것을 포함하여, WO 2011/092592에 개시된 영역 및/또는 유전자; 또는
    - AIRE, SIM2, 및 ERG 중에서 선택된 영역 및/또는 유전자, 또는 이 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열; 또는
    - PDE9A, PPP1R2P2, CBR1, DSCAM, C21orf29, 및 HLCS 중에서 선택된 영역 및/또는 유전자, 또는 이 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열; 또는
    - C21orf57의 영역 및/또는 유전자, 또는 상기 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열; 또는
    - WO 2011/034631의 서열번호 33, 34, 35, 36, 37, 38, 39, 176, 179, 180, 184, 188, 189, 190, 191, 193, 195, 198, 199, 200, 201, 202, 203, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 221, 223, 225, 226, 231, 232, 233, 235, 239, 241, 257, 258, 259, 및 261
    중에서 독립적으로 선택된 영역 및/또는 유전자에 위치하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  31. 제1항 내지 제30항 중 어느 한 항에 있어서, 상기 제1 표적 DMR 및/또는 상기 선택적인 제2 표적 DMR은 각각,
    - VAPA-APCDDI의 영역 및/또는 유전자 또는 이 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열; 또는
    - maspin의 영역 및/또는 유전자 또는 이 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열; 또는
    - WO 2011/034631의 서열번호 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 및 32
    중에서 독립적으로 선택된 영역 및/또는 유전자에 위치하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  32. 제1항 내지 제31항 중 어느 한 항에 있어서, 상기 제1 표적 DMR 및/또는 상기 선택적인 제2 표적 DMR은 각각
    - WO 2011/034631의 서열번호 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 및 20 중에서 독립적으로 선택된 영역 및/또는 유전자에 위치하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  33. 제1항 내지 제32항 중 어느 한 항에 있어서, 상기 기준 DMR은 각각,
    - RASSF1A, TBX3, ZFY, CDC42EP1, PCDHGA1, SOX14, 및 SPN 중에서 선택된 영역 및/또는 유전자, 또는 이 영역 및/또는 유전자로부터 상류 및/또는 하류로 10kbp, 5kbp, 1kbp, 500bp, 250bp, 150bp, 100bp, 또는 50bp를 넘지 않는 DNA 서열; 또는
    - WO 2011/034631의 서열번호 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 및 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 및 163
    중에서 독립적으로 선택된 영역 및/또는 유전자에 위치하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  34. 제1항 내지 제33항 중 어느 한 항에 있어서, 단계 (c) 및 단계 (d), 선택적 임의 단계 (c)' 및 선택적 임의 단계 (f)에서 다수의 결정 세트가 수행되되, 이 결정 세트에 속하는 각 결정은 상기 시료의 DNA의 상이한 분취량을 사용하여 상이한 용기에서 그리고 다수 결정 세트에 속하는 각 결정에 대해 유효하게 동시에 수행되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  35. 제34항에 있어서, 상기 다수 결정 세트는 2 내지 약 50 세트, 특히 2 내지 약 20 세트, 2 내지 약 10 세트, 또는 약 5 내지 약 15 세트이며, 바람직하게는 상기 다수의 결정 세트는 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 및 12 세트 중에서 선택되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  36. 제34항 또는 제35항에 있어서, 단계 (e) 및 선택적 임의 단계 (e)'에서 결정되는 상대적 양(들) 또는 비율(들)은 단계 (c) 및 단계 (d) 그리고 선택적 임의 단계 (c)' 및 선택적 임의 단계 (f)에서 수행된 다수의 결정 세트에 의해 결정되되, 바람직하게는 각 세트에서 결정된 DNA의 평균 양, 특히, 각 세트에서 결정된 DNA 양의 평균값, 중앙값, 또는 최빈값, 바람직하게는 각 세트에서 결정된 DNA 양의 평균값을 사용하여 결정되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  37. 제1항 내지 제36항 중 어느 한 항에 있어서, 상기 방법은 각각 다른 임신여성로부터 채취된 다수의 시료에 대해 수행되고, 각 방법은 별도의 용기에서 수행되며, 다수의 시료들 각각에 대해 유효하게 동시 수행되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  38. 제37항에 있어서, 상기 다수의 시료는 2 내지 약 500개의 시료, 특히, 2 내지 약 200개, 2 내지 약 100개, 또는 약 5 내지 약 150개의 시료이며, 바람직하게는 상기 다수의 시료는 각각 다른 임신여성에게서 채취된 약 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 120, 및 140 개의 시료들 중 선택되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  39. 이전 청구항들 중 어느 한 항에 있어서 제4항에 종속되는 경우에, 상기 각 결정 단계에서, 상기 제1 표적 DNA 종 및 상기 선택적인 제2 표적 DNA 종의 상기 결정된 양의 각각은, 상기 시료의 총 DNA에 대한 상기 제1 표적 DNA 종의 상대 농도, 그리고 상기 시료의 총 DNA에 대한 상기 선택적인 제2 표적 DNA 종의 상대 농도로 표시되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  40. 제1항 내지 제38항 중 어느 한 항에 있어서,
    - 단계 (c)와 단계 (d)에서, 그리고 선택적 임의 단계 (c)'와 선택적 임의 단계 (f)에서 사용된 것과 동일한 DMR에 대하여, 기지의 양의 표준 DNA 시료에서 DNA 양을 결정하는 단계; 그리고
    - 상기 표준 DNA 시료로부터 검출된 신호를, 단계 (c) 및 단계 (d), 그리고 선택적 임의 단계 (c)' 및 선택적 임의 단계 (f)에서 검출된 각각의 신호와 비교하는 단계를 추가로 포함하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  41. 제40항에 있어서, 표준 DNA 시료는 기지 농도의 인간 게놈 DNA 시료인, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  42. 제40항 또는 제41항에 있어서, 상기 각 결정 단계에서,
    상기 제1 표적 DNA 종, 그리고 상기 선택적인 제2 표적 DNA 종 및 상기 기준 DNA 종의 상기 결정된 양의 각각은, 상기 시료 내 상기 DNA 종의 절대적 양으로 표시되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  43. 제1항 내지 제42항 중 어느 한 항에 있어서, 제1 표적 DNA 종의 양은 제1 표적 DMR 중 하나에서의 메틸화 검출량으로부터 결정되고, 제1 표적 DNA 종의 양은 제1 표적 DMR 중 다른 것에서의 메틸화 검출량으로부터 결정되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  44. 제43항에 있어서, 단계 (e)에서 둘 이상의 상대적 량(들), 바람직하게는 비율(들)은 제1 표적 DNA 종의 둘 이상의 양에 대해 결정되되, 각각은 하나 이상의 상기 제1 표적 DMR에 대하여 결정되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  45. 제44항에 있어서, 상기 둘 이상의 상대적 양(들) 또는 비율은 태아 내 염색체 이수성의 존재 또는 부존재를 지시하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  46. 제45항에 있어서 제2항에 종속되는 경우에, 상기 단계 (e)에서, 상기 둘 이상의 상대적 양(들) 또는 비율(들)을 임계값(들) 및/또는 기준 분포(들)와 비교시에, 상기 둘 이상의 상대적 양(들) 또는 비율(들)이 상기 임계값(들) 및/또는 기준 분포(들)보다 높거나 낮은 것은 태아 내의 염색체 이수성의 존재를 지시하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  47. 제1항 내지 제46항 중 어느 한 항에 있어서 제2항에 종속되는 경우에, 임계값 및/또는 기준 분포는 상이한 임신여성으로부터 각각 채취된 다수의 시료로부터 결정되되, 특히, 제37항 내지 제38항 중 어느 한 항에 기재된 방법의 실행에 의해 결정되며;
    선택적으로, 다수의 결정 세트가 단계 (c) 및 단계 (d), 그리고 선택적 임의 단계 (c)' 및 선택적 임의 단계 (f)에서 각 시료에 대해 수행되되, 특히 제34항 내지 제36항 중 어느 한 항에 기재된 방법의 실행에 의해 수행되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  48. 제47항에 있어서, 상기 다수의 시료들의 둘 이상의 그룹이 그룹별로 분석되되, 특히, 각 그룹을 별도의 실행, 분석, 또는 마이크로타이터 플레이트에서 분석되고, 상기 임계값 및/또는 기준 분포는 각 시료들의 그룹으로부터 결정된 양(들) 또는 비율(들)의 정규화에 의해 결정되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  49. 제48항에 있어서, 시료 그룹들 간의 상기 정규화는 시료 특이적 양 또는 비율(특히, 시료에 대해 여러 세트 행해진 결정의 평균값) 및 상기 특정 시료가 속한 동일 그룹 내의 모든 시료에 대해 결정된 양 또는 비율의 평균(예를 들어, 중앙값) 간의 차이를 고려하여 수행되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  50. 제47항 내지 제49항 중 어느 한 항에 있어서, 태아 내의 염색체 이수성의 존재는, 임계값(들) 및/또는 기준 분포(들)와 비교된 하나 이상의 제1 표적 DMR에 대해 결정된 양(들) 또는 비율(들)의 이탈값(outlier)인 해당 태아에 대한 시료 특이적 양 또는 비율에 의해 지시되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  51. 제50항에 있어서, 태아에의 염색체 이수성의 존재는 다음의 (a) 및/또는 (b)에 제시된 위치, 즉, (a) 정배수체인(추정되는) 다수의 다른 태아에 대한 시료 특이적 양 또는 비율이 모여 있는 수치집단의 외부; 및/또는 (b) 염색체 이수성을 갖는 태아들을 나타내는 다수의 다른 시료들 ― 여기서 상기 태아들을 나타내는 상기 다수의 다른 시료들은 약 2~10, 12~15, 16~25, 26~30, 32~40, 42~50, 52~75, 78~100 , 105-125, 130-150, 155-175, 180-200, 205-250, 255-300, 305-350, 355-400, 405-450, 455-500, 및 500개 초과 중에서 선택된 다른 시료들임 ― 에 대한 시료 특이적 양 또는 비율이 모인 수치집단의 내부
    에 모여있는 수치집단에 위치하는 해당 태아에 대한 시료 특이적 양 또는 비율에 의해 지시되는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  52. 제1항 내지 제51항 중 어느 한 항에 있어서, 단계 (b) 이전에, 상기 임신여성에게서 채취한 상기 시료를 처리하여 상기 시료에 존재하는 DNA를 추출하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  53. 제52항에 있어서, 상기 시료에 존재하는 DNA를 추출하는 단계에서는 상기 시료의 전체 무세포 DNA를 추출하거나, 태아 무세포 DNA를 추출 및/또는 농축하는, 임신여성에 수태된 태아의 염색체 이수성을 검출하는 방법.
  54. 임신여성이 임신관련 의학적 증상을 앓고 있는 또는 발병할 위험의 증가를 감지하는 방법으로서, 이 방법은
    (i) 제1항 내지 제53항 중 어느 한 항이 제4항에 종속되는 경우의 상기 방법을 수행하는 단계;
    (ii) 시료에 존재하는 태아 DNA의 적어도 하나의 양, 특히, 절대적 양 또는 상대적 양을 결정하는 단계; 그리고
    (ⅲ) 결정된 태아 DNA의 양을 임계값 및/또는 기준 분포와 비교하는 단계를 포함하되,
    여기서 상기 임계값 및/또는 기준 분포로부터 상기 태아 DNA의 양이 증가 또는 이탈하는 것은 임신여성이 상기 임신관련 의학적 증상을 앓고 있는 또는 발병할 위험이 증가하는 것을 지시하는, 임신여성이 임신관련 의학적 증상을 앓고 있는 또는 발병할 위험의 증가를 감지하는 방법.
  55. 상기 둘 이상의 제1 표적 DMR 중 하나를 검출하기 위한, 제10항에 기재된 둘 이상의 표지처리된 프로브를 포함하는 조성물.
  56. 제55항에 있어서,
    - 제1항 내지 제53항 중 어느 한 항에 기재된 상기 둘 이상의 제1 표적 DMR 중 하나를 증폭시키기 위한 2쌍 이상의 PCR 프라이머쌍(각 쌍이 하나를 증폭시킴); 및/또는
    - 상기 둘 이상의 기준 DMR 중 하나를 검출하기 위한 제11항에 기재된 둘 이상의 표지처리된 프로브(각 프로브가 하나를 검출함); 및/또는
    - 제1항 내지 제53항 중 어느 한 항에 기재된 상기 둘 이상의 기준 DMR 중 하나를 증폭시키기 위한 2쌍 이상의 PCR 프라이머쌍(각 쌍이 하나를 증폭시킴)를 추가로 포함하는 조성물.
  57. 제55항 또는 제56항에 있어서,
    - 제4항 내지 제53항 중 어느 한 항에 기재된 상기 적어도 하나의 OR 중 하나를 증폭시키기 위한 적어도 한 쌍의(바람직하게는 두 쌍의) 다른 PCR 프라이머쌍(각 쌍이 하나를 증폭시킴); 및/또는
    - 상기 적어도 하나의 OR을 검출하기 위한 제12항에 기재된 적어도 하나의(바람직하게는 2개의) 표지처리된 다른 프로브(각 프로브가 하나를 검출함)를 추가로 포함하는 조성물.
  58. 제55항 내지 제57항 중 어느 한 항에 있어서,
    - 상기 둘 이상의 제2 표적 DMR을 검출하기 위한 제10항에 기재된 둘 이상의 표지처리된 다른 프로브(각 프로브가 하나를 검출함); 및/또는
    - 제6항 내지 제53항 중 어느 한 항에 기재된 상기 둘 이상의 제2 표적 DMR 중 하나를 증폭시키기 위한 두 쌍 이상의 다른 PCR 프라이머쌍(각 쌍이 하나를 증폭시킴)을 추가로 포함하는 조성물.
  59. 임신여성이 수태한 태아의 염색체 이수성을 검출하기 위한 그리고/또는 의학적 증상을 앓거나 발병할 위험의 증가를 감지하기 위한 키트로서, 이 키트는
    - 제55항 내지 제58항 중 어느 한 항에 기재된 프라이머 및/또는 프로브의 조합을 포함하고,
    - 선택적으로, (i) 제1항 내지 제53항 중 어느 한 항의 방법을 실시하고 및/또는 제55항 내지 제58항 중 어느 한 항의 조성물을 제조 또는 사용하기 위한 상기 프라이머 및/또는 프로브의 사용 지침이 포함된 인쇄 매뉴얼 또는 컴퓨터 판독가능 메모리; 및/또는 (ii) 제1항 내지 제53항 중 어느 한 항의 방법을 실시하고 및/또는 제55항 내지 제58항 중 어느 한 항의 조성물을 제조 또는 사용하는 데 유용한 하나 이상의 다른 품목, 구성품, 또는 시약을 추가로 포함하는 키트.
  60. 제59항에 있어서,
    - 상기 임신여성으로부터 채취된 조직 시료, 특히, 혈액을 수집 및/또는 저장하는 수단 ― 이 수단은 채혈 수단임; 및/또는
    - 상기 임신여성으로부터 채취된 시료로부터 DNA(바람직하게는 무세포 DNA)를 추출하는 수단 ― 이 수단은 무세포 DNA 추출 키트임; 및/또는
    - 제1항 내지 제53항 중 어느 한 항의 방법의 맥락에서 상기 수단들 중 하나 또는 모두를 식별, 취득, 및/또는 사용하기 위한 지침이 포함된 인쇄 매뉴얼 또는 컴퓨터 판독가능 메모리 중 하나 이상의 구성품을 추가로 포함하는 키트.
  61. 제1항 내지 제53항 중 어느 한 항에 기재된 바와 같이 임신여성에 수태된 태아의 염색체 이수성을 검출하기 위해 임신여성에게서, 모체에서 유래한 상이하게 메틸화된 DNA와 혼합된 태아 및/또는 태아 태반에서 유래한 DNA를 포함하는 시료를 채취하고, 이 시료에 존재하는 DNA를 본 발명 방법에서 일어나는 메틸화된 DNA 및 메틸화되지 않은 DNA를 상이하게 변형시키는 시약으로 처리하는 검출하기 위한 연산을 수행 및/또는 관리하도록 컴퓨팅 시스템을 제어하기 위한 다수의 명령어로 인코딩된 컴퓨터 판독가능 매체를 포함하는 컴퓨터 프로그램 제품에 있어서, 상기 연산은
    - 제1항 내지 제53항 중 어느 한 항의 단계 (c)에 기재된 것과 같이 상기 시료에 존재하는 염색체 이수성에 관련된 염색체인 제1 표적 DNA종의 양을 각각 나타내는 2개의 신호 (i), 및 제1항 내지 제53항 중 어느 한 항의 단계 (d)에 기재된 것과 같이 상기 시료에 존재하는 하나 이상의 기준 염색체인 기준 DNA 종의 양을 나타내는 하나의 신호 (ii)를 수신하는 단계;
    - 수신된 신호 (ii)가 나타내는 기준 염색체의 양에 대한, 수신된 적어도 하나의 신호 (i)이 나타내는 염색체 이수성에 관련된 염색체의 적어도 하나의 상대적 양(들)에 기초하여, 상기 임신여성이 수태한 태아에 염색체 이수성의 존재여부의 유형을 정하는 단계 ― 여기서 적어도 하나는 태아 내의 염색체 이수성의 존재 또는 부존재를 지시함 ― 를 포함하는, 컴퓨터 프로그램 제품.
  62. 제61항에 있어서, 단계 (c) 및 단계 (d)에서 결정된 상기 DNA의 양을 나타내는 신호들은 상기 시료의 동일 분취량을 사용하여 그리고 동일한 용기에서 생성되고, 또 상기 제1 표적 DMR들 및 상기 기준 DMR들에 대해 유효하게 동시에 생성되고, 그리고 선택적으로, (x) 상기 적어도 두 개의 기준 DMR에 대해 동일한 검출 표지(들)를 사용하여서, 그리고 (y) 상기 적어도 두 개의 제1 표적 DMR에 대해 상이한 검출 표지(들)를 사용하여 생성되는, 컴퓨터 프로그램 제품.
  63. 제61항 또는 제62항에 있어서, 상기 연산은 임계값(들) 및/또는 기준 분포(들)와 비교함으로써 상기 유형을 정하되, 여기서 상기 상대적 양(들) 또는 비율(들) 중 하나 이상이 상기 임계값(들) 및/또는 기준 분포(들)보다 높거나 낮은 것은 태아에 염색체 이수성이 존재하는지를 지시하는, 컴퓨터 프로그램 제품.
  64. 제63항에 있어서, 상기 연산은, 상이한 임신여성로부터 각각 채취한 다수의 시료에 관련된 상기 (ⅰ) 및 (ⅱ)의 다수의 신호를 수신함으로써 상기 다수의 시료로부터 상기 임계값(들) 및/또는 기준 분포(들)을 계산하되, 여기서 선택사항으로 상기 다수의 시료는 제1항 내지 제53항 중 어느 한 항의 방법에 의해 하나 이상의 시료 그룹에서 분석되고, 상기 방법은 별도의 용기에서 특정 그룹에 속하는 각 시료에 대해 수행되며, 해당 그룹 내 다수 시료들의 다른 구성 시료와 유효하게 동시에 수행되는, 컴퓨터 프로그램 제품.
  65. 제61항 내지 제64항 중 어느 한 항에 있어서, 상기 연산은,
    - 제4항에 기재된 상기 시료 내의 전체 DNA 양을 나타내는 다른 신호 (iii)을 수신하는 단계; 그리고
    - 적어도 하나의 수신 신호 (i) 및/또는 (ii)와 함께 상기 수신된 신호 (iii)을 고려하여 시료 내에 존재하는 태아 DNA의 양 ― 특히, 절대적 양 또는 상대적 양 ― 을 결정하는 단계를 추가로 포함하는, 컴퓨터 프로그램 제품.
  66. 제65항에 있어서, 상기 연산은,
    - 현재의 상기 태아 DNA의 양을 임계값 및/또는 기준 분포와 비교하여 임신여성이 임신관련 의학적 증상을 앓고 있는 또는 발병할 위험이 증가하는지의 유형을 정하는 단계를 추가로 포함하되, 여기서 상기 임계값 및/또는 기준 분포로부터 상기 태아 DNA의 양이 증가하거나 이탈값을 보이는 것은 임신여성이 상기 임신관련 의학적 증상을 앓고 있는 또는 발병할 위험이 증가하는 것을 지시하는, 컴퓨터 프로그램 제품.
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