CA2405704C - Analogues de bombesine utilises dans le traitement du cancer - Google Patents

Analogues de bombesine utilises dans le traitement du cancer Download PDF

Info

Publication number
CA2405704C
CA2405704C CA2405704A CA2405704A CA2405704C CA 2405704 C CA2405704 C CA 2405704C CA 2405704 A CA2405704 A CA 2405704A CA 2405704 A CA2405704 A CA 2405704A CA 2405704 C CA2405704 C CA 2405704C
Authority
CA
Canada
Prior art keywords
peptide
trp
alpha
aib
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2405704A
Other languages
English (en)
Other versions
CA2405704A1 (fr
Inventor
Anand C. Burman
Sudhanand Prasad
Rama Mukherjee
Manu Jaggi
Anu T. Singh
Archna Mathur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Dabur Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dabur Pharma Ltd filed Critical Dabur Pharma Ltd
Publication of CA2405704A1 publication Critical patent/CA2405704A1/fr
Application granted granted Critical
Publication of CA2405704C publication Critical patent/CA2405704C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086—Bombesin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne de nouveaux peptides, en l'occurrence des antagonistes de la bombésine et des peptides du type bombésine, qui sont utiles dans le traitement du cancer. L'invention concerne, en particulier, la conception et la synthèse de ces nouveaux peptides qui comprennent des .alpha.,.alpha.-acides aminés d'une manière spécifique au site. L'invention concerne, en outre, des procédés de génération desdits peptides, des compositions les renfermant et les applications pharmacologiques de ces peptides, notamment dans le traitement et la prévention du cancer.
CA2405704A 2000-02-24 2000-07-31 Analogues de bombesine utilises dans le traitement du cancer Expired - Fee Related CA2405704C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN147/DEL/2000 2000-02-24
IN147DE2000 2000-02-24
PCT/US2000/020873 WO2001062777A1 (fr) 2000-02-24 2000-07-31 Analogues de bombesine utilises dans le traitement du cancer

Publications (2)

Publication Number Publication Date
CA2405704A1 CA2405704A1 (fr) 2001-08-30
CA2405704C true CA2405704C (fr) 2010-11-16

Family

ID=11097032

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2405704A Expired - Fee Related CA2405704C (fr) 2000-02-24 2000-07-31 Analogues de bombesine utilises dans le traitement du cancer

Country Status (4)

Country Link
EP (1) EP1261626A1 (fr)
AU (1) AU2000265053A1 (fr)
CA (1) CA2405704C (fr)
WO (1) WO2001062777A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7173006B2 (en) * 2002-12-23 2007-02-06 Dabur Research Foundation Drug comprising synthetic peptide analogs for the treatment of cancer
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US8420050B2 (en) 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7611692B2 (en) 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7922998B2 (en) 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
BRPI0418194A (pt) * 2003-12-24 2007-04-27 Bracco Imaging Spa compostos peptìdeos liberadores de gastrina aperfeiçoados
AU2008303922A1 (en) * 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of the peptide His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe alone or in combination with the peptide Gly-Ard-Gly-Asp-Asn-Pro-OH as a therapeutic agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU618029B2 (en) * 1987-11-02 1991-12-12 Imperial Chemical Industries Plc Polypeptide compounds
GB8813356D0 (en) * 1988-06-06 1988-07-13 Ici Plc Polypeptide compounds
AU641789B2 (en) * 1990-07-26 1993-09-30 Aventisub Ii Inc. Peptides
US6492330B1 (en) * 1996-08-16 2002-12-10 National Institute Of Immunology Antiangiogenic drugs

Also Published As

Publication number Publication date
CA2405704A1 (fr) 2001-08-30
WO2001062777A1 (fr) 2001-08-30
AU2000265053A1 (en) 2001-09-03
EP1261626A1 (fr) 2002-12-04

Similar Documents

Publication Publication Date Title
JP3957751B2 (ja) 新規ドラスタチン誘導体、その製法及び使用
KR100225679B1 (ko) 노나펩티드 봄베신 길항제
NO321380B1 (no) Heptapeptid analog med oksytocinantagonistaktivitet, fremgangsmate ved fremstilling derav samt anvendelse derav til fremstilling av medikamenter.
KR100286242B1 (ko) 돌라스타틴 유도체
US6489297B1 (en) Vasoactive intestinal peptide analogs
HU218288B (en) Bombesin-antagonistic polypeptide derivatives and pharmaceutical compositions containing them
US20040122013A1 (en) Analogs of nocicettin
CA2405704C (fr) Analogues de bombesine utilises dans le traitement du cancer
US6316414B1 (en) Somatostatin analogs for the treatment of cancer
CN108976287A (zh) 一类阿片和神经肽ff受体多靶点分子bn-9的二硫键环化类似物及其制备方法与应用
JP2001514659A (ja) ドラスタチン−１５誘導体とタキサンとの併用
EP1198478B1 (fr) Analogues de la somatostatine destines au traitement du cancer
CA2405724C (fr) Analogues de la substance p destines au traitement du cancer
US6596692B1 (en) Substance P analogs for the treatment of cancer
US6989371B1 (en) Bombesin analogs for treatment of cancer
JP2004002331A (ja) 肝臓癌の治療
EP2198878A1 (fr) Antagonistes de bombésine en polypeptide
EP1593686B1 (fr) Peptides antinéoplastiques
TWI237029B (en) Vasoactive intestinal peptide analogs
US6949513B2 (en) Polypeptides of covalently linked synthetic bioactive peptide analog(s) for treatment of cancer
JPH09502427A (ja) オキシトシン拮抗薬活性を示すペプチド
CA2008454A1 (fr) Analogue lineaire d'un grp mammalien ou de la bombesine amphibienne biologiquement actif
CA2405689A1 (fr) Analogues peptidiques vasoactifs intestinaux

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed