CA2406169C - Derives d'acide nucleique polyamide, et agents et procedes permettant de les preparer - Google Patents
Derives d'acide nucleique polyamide, et agents et procedes permettant de les preparer Download PDFInfo
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- CA2406169C CA2406169C CA2406169A CA2406169A CA2406169C CA 2406169 C CA2406169 C CA 2406169C CA 2406169 A CA2406169 A CA 2406169A CA 2406169 A CA2406169 A CA 2406169A CA 2406169 C CA2406169 C CA 2406169C
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- pna
- pna derivative
- derivative
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P31/12—Antivirals
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- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Polyamides (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
L'invention concerne des dérivés d'acide nucléique polyamide qui portent, en position terminale C ou C et N du tronc d'acide nucléique polyamide, un ou plusieurs restes phosphoryle qui portent quant à eux, éventuellement un ou plusieurs groupes marqueurs ou des groupes de réticulation transversale ou des groupes favorisant l'absorption intracellulaire ou des groupes qui augmentent l'affinité de liaison du dérivé d'ADN pour des acides nucléiques. L'invention concerne par ailleurs un procédé permettant de préparer les dérivés d'acide nucléique polyamide mentionnés ci-dessus, ainsi que leur utilisation comme médicament ou agent diagnostique.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10019135A DE10019135A1 (de) | 2000-04-18 | 2000-04-18 | Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung |
| DE10019135.5 | 2000-04-18 | ||
| PCT/EP2001/004030 WO2001079216A2 (fr) | 2000-04-18 | 2001-04-07 | Derives d"acide nucleique polyamide, agents et procedes permettant de les preparer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2406169A1 CA2406169A1 (fr) | 2001-10-25 |
| CA2406169C true CA2406169C (fr) | 2012-06-19 |
Family
ID=7639143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2406169A Expired - Fee Related CA2406169C (fr) | 2000-04-18 | 2001-04-07 | Derives d'acide nucleique polyamide, et agents et procedes permettant de les preparer |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US6905820B2 (fr) |
| EP (1) | EP1276760B1 (fr) |
| JP (1) | JP4908714B2 (fr) |
| KR (1) | KR100842723B1 (fr) |
| AR (1) | AR032153A1 (fr) |
| AT (1) | ATE344276T1 (fr) |
| AU (1) | AU5479501A (fr) |
| BR (1) | BR0110110A (fr) |
| CA (1) | CA2406169C (fr) |
| CY (1) | CY1105958T1 (fr) |
| DE (2) | DE10019135A1 (fr) |
| DK (1) | DK1276760T3 (fr) |
| ES (1) | ES2275677T3 (fr) |
| IL (2) | IL152288A0 (fr) |
| MX (1) | MXPA02009953A (fr) |
| NO (1) | NO333193B1 (fr) |
| NZ (1) | NZ521988A (fr) |
| PT (1) | PT1276760E (fr) |
| TW (1) | TWI298328B (fr) |
| WO (1) | WO2001079216A2 (fr) |
| ZA (1) | ZA200208344B (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6518017B1 (en) * | 1997-10-02 | 2003-02-11 | Oasis Biosciences Incorporated | Combinatorial antisense library |
| US20030165888A1 (en) * | 2001-07-18 | 2003-09-04 | Brown Bob D. | Oligonucleotide probes and primers comprising universal bases for diagnostic purposes |
| DE60023480T2 (de) * | 1999-04-08 | 2006-07-20 | Gen-Probe Inc., San Diego | Amplifikation und sequenzierung von primer-paaren und deren verwendung |
| DE10019135A1 (de) * | 2000-04-18 | 2001-10-31 | Aventis Pharma Gmbh | Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung |
| TWI286849B (en) * | 2003-03-25 | 2007-09-11 | Nichia Corp | Positive electrode active material for nonaqueous electrolyte secondary battery and nonaqueous electrolyte secondary battery |
| WO2008150832A1 (fr) * | 2007-05-31 | 2008-12-11 | Sanofi-Aventis | Procédés d'analyse pour identifier des agents qui modifient l'activité de nape-fld ou abh4 |
| WO2009044403A2 (fr) * | 2007-10-05 | 2009-04-09 | Juvenis Ltd. | Compositions polymères biodégradables injectables pour la réparation et l'augmentation des tissus mous |
| US20090276700A1 (en) * | 2008-04-30 | 2009-11-05 | Nokia Corporation | Method, apparatus, and computer program product for determining user status indicators |
| US20090276855A1 (en) * | 2008-04-30 | 2009-11-05 | Nokia Corporation | Method, apparatus, and computer program product that provide for presentation of event items |
| US20090276412A1 (en) * | 2008-04-30 | 2009-11-05 | Nokia Corporation | Method, apparatus, and computer program product for providing usage analysis |
| US20090276436A1 (en) * | 2008-04-30 | 2009-11-05 | Nokia Corporation | Method, apparatus, and computer program product for providing service invitations |
| US20090292762A1 (en) * | 2008-05-20 | 2009-11-26 | Nokia Corporation | Method, Apparatus, and Computer Program Product for Publishing Content |
| US20090327434A1 (en) * | 2008-06-30 | 2009-12-31 | Nokia Corporation | Method, Apparatus, and Computer Program Product for Anonymous Polling |
| USD696048S1 (en) * | 2010-08-12 | 2013-12-24 | Sealy Technology, Llc | Mattress |
| JP5990987B2 (ja) * | 2012-04-11 | 2016-09-14 | 株式会社Ihi | 微生物固定方法、および微生物検出方法 |
| JP2015172904A (ja) * | 2014-03-12 | 2015-10-01 | 株式会社東芝 | Ｌｄｏ型電圧レギュレータ、及び、受電装置 |
| WO2016123244A1 (fr) * | 2015-01-27 | 2016-08-04 | Indicator Systems International, Inc. | Conjugués polymères de fluorescéine |
| KR102659194B1 (ko) * | 2016-07-26 | 2024-04-19 | 삼성전자주식회사 | 홀로그래픽 디스플레이 장치용 박형 백라이트 유닛 및 이를 포함하는 홀로그래픽 디스플레이 장치 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989003849A1 (fr) * | 1987-10-28 | 1989-05-05 | Howard Florey Institute Of Experimental Physiology | Conjugues d'oligonucleotide-polyamide |
| DK51092D0 (da) | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| IL112920A (en) * | 1994-03-07 | 2003-04-10 | Dow Chemical Co | Composition comprising a dendritic polymer complexed with at least one unit of biological response modifier and a process for the preparation thereof |
| DE4408528A1 (de) | 1994-03-14 | 1995-09-28 | Hoechst Ag | Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung |
| DE4408531A1 (de) * | 1994-03-14 | 1995-09-28 | Hoechst Ag | PNA-Synthese unter Verwendung einer gegen schwache Säuren labilen Amino-Schutzgruppe |
| AU3999495A (en) * | 1994-10-06 | 1996-05-02 | Buchardt, Dorte | Peptide nucleic acid conjugates |
| ATE206131T1 (de) * | 1995-03-13 | 2001-10-15 | Aventis Pharma Gmbh | Phosphonomonoesternnukleinsäuren, verfahren zu ihrer herstellung und ihre verwendung |
| DE19508923A1 (de) * | 1995-03-13 | 1996-09-19 | Hoechst Ag | Phosphonomonoesternukleinsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung |
| DE19640974A1 (de) * | 1996-10-04 | 1998-04-16 | Bayer Ag | Bausteine für DNA/PNA-Cooligomere |
| DE19757516A1 (de) * | 1997-12-23 | 1999-06-24 | Roche Diagnostics Gmbh | Modifizierte Nukleinsäureanaloga |
| US6326479B1 (en) * | 1998-01-27 | 2001-12-04 | Boston Probes, Inc. | Synthetic polymers and methods, kits or compositions for modulating the solubility of same |
| US6043352A (en) * | 1998-08-07 | 2000-03-28 | Isis Pharmaceuticals, Inc. | 2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides |
| DE10019135A1 (de) * | 2000-04-18 | 2001-10-31 | Aventis Pharma Gmbh | Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung |
| DE10019136A1 (de) * | 2000-04-18 | 2001-10-31 | Aventis Pharma Gmbh | Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung |
-
2000
- 2000-04-18 DE DE10019135A patent/DE10019135A1/de not_active Ceased
-
2001
- 2001-04-07 DK DK01927897T patent/DK1276760T3/da active
- 2001-04-07 KR KR1020027013932A patent/KR100842723B1/ko not_active Expired - Fee Related
- 2001-04-07 IL IL15228801A patent/IL152288A0/xx unknown
- 2001-04-07 AT AT01927897T patent/ATE344276T1/de active
- 2001-04-07 PT PT01927897T patent/PT1276760E/pt unknown
- 2001-04-07 EP EP01927897A patent/EP1276760B1/fr not_active Expired - Lifetime
- 2001-04-07 NZ NZ521988A patent/NZ521988A/xx not_active IP Right Cessation
- 2001-04-07 WO PCT/EP2001/004030 patent/WO2001079216A2/fr not_active Ceased
- 2001-04-07 JP JP2001576814A patent/JP4908714B2/ja not_active Expired - Fee Related
- 2001-04-07 BR BR0110110-2A patent/BR0110110A/pt not_active IP Right Cessation
- 2001-04-07 DE DE50111371T patent/DE50111371D1/de not_active Expired - Lifetime
- 2001-04-07 MX MXPA02009953A patent/MXPA02009953A/es active IP Right Grant
- 2001-04-07 CA CA2406169A patent/CA2406169C/fr not_active Expired - Fee Related
- 2001-04-07 ES ES01927897T patent/ES2275677T3/es not_active Expired - Lifetime
- 2001-04-07 AU AU5479501A patent/AU5479501A/xx not_active Withdrawn
- 2001-04-16 AR ARP010101766A patent/AR032153A1/es unknown
- 2001-04-17 US US09/835,371 patent/US6905820B2/en not_active Expired - Fee Related
- 2001-05-16 TW TW090108986A patent/TWI298328B/zh not_active IP Right Cessation
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2002
- 2002-10-14 IL IL152288A patent/IL152288A/en not_active IP Right Cessation
- 2002-10-15 NO NO20024959A patent/NO333193B1/no not_active IP Right Cessation
- 2002-10-16 ZA ZA200208344A patent/ZA200208344B/en unknown
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2004
- 2004-06-02 US US10/858,658 patent/US20050009073A1/en not_active Abandoned
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2007
- 2007-01-29 CY CY20071100108T patent/CY1105958T1/el unknown
- 2007-09-14 US US11/855,443 patent/US7550582B2/en not_active Expired - Fee Related
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2009
- 2009-05-29 US US12/474,532 patent/US7897346B2/en not_active Expired - Fee Related
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2011
- 2011-01-24 US US13/012,266 patent/US8268560B2/en not_active Expired - Fee Related
Also Published As
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| MKLA | Lapsed |
Effective date: 20150407 |