CA2413683A1 - Modulateurs cycliques condenses de la fonction du recepteur hormonal nucleaire - Google Patents

Modulateurs cycliques condenses de la fonction du recepteur hormonal nucleaire Download PDF

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Publication number
CA2413683A1
CA2413683A1 CA002413683A CA2413683A CA2413683A1 CA 2413683 A1 CA2413683 A1 CA 2413683A1 CA 002413683 A CA002413683 A CA 002413683A CA 2413683 A CA2413683 A CA 2413683A CA 2413683 A1 CA2413683 A1 CA 2413683A1
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Prior art keywords
alpha
substituted
methanoimidazo
alkyl
dione
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CA002413683A
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Mark E. Salvati
James Aaron Balog
Weifang Shan
Soren Giese
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Bristol Myers Squibb Co
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Individual
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

L'invention concerne des composés cycliques condensés, des procédés d'utilisation de tels composés dans le traitement d'états associés au récepteur hormonal nucléaire, tels que le cancer et les troubles immuns, ainsi que des compositions pharmaceutiques contenant de tels composés.
CA002413683A 2000-06-28 2001-06-20 Modulateurs cycliques condenses de la fonction du recepteur hormonal nucleaire Abandoned CA2413683A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US21439200P 2000-06-28 2000-06-28
US60/214,392 2000-06-28
US28461701P 2001-04-18 2001-04-18
US28443801P 2001-04-18 2001-04-18
US60/284,438 2001-04-18
US60/284,617 2001-04-18
PCT/US2001/019663 WO2002000653A2 (fr) 2000-06-28 2001-06-20 Modulateurs cycliques condenses de la fonction du recepteur hormonal nucleaire

Publications (1)

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CA2413683A1 true CA2413683A1 (fr) 2002-01-03

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CA002413683A Abandoned CA2413683A1 (fr) 2000-06-28 2001-06-20 Modulateurs cycliques condenses de la fonction du recepteur hormonal nucleaire

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EP (1) EP1299385A2 (fr)
JP (1) JP2004515462A (fr)
AU (1) AU2002215609A1 (fr)
BR (1) BR0111869A (fr)
CA (1) CA2413683A1 (fr)
HU (1) HUP0303165A3 (fr)
MX (1) MXPA02012563A (fr)
NO (1) NO20026167D0 (fr)
NZ (1) NZ523802A (fr)
WO (1) WO2002000653A2 (fr)

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JP2000264876A (ja) * 1998-09-10 2000-09-26 Sumitomo Chem Co Ltd 縮合複素環化合物
BR0111298A (pt) * 2000-06-28 2005-05-10 Bristol Myers Squibb Co Moduladores seletivos dos receptores de andrógenos e métodos para identificação, projeto e uso dos mesmos
US7001911B2 (en) 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
US20030114420A1 (en) * 2000-06-28 2003-06-19 Salvati Mark E. Fused cyclic modulators of nuclear hormone receptor function
US20040077605A1 (en) 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
WO2002020526A2 (fr) * 2000-09-07 2002-03-14 Bayer Pharmaceuticals Corporation Amidines cycliques et acycliques et compositions pharmaceutiques contenant ces composes utilises comme agents de liaison de recepteur de progesterone
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
DE60228330D1 (de) * 2001-12-19 2008-09-25 Bristol Myers Squibb Co Kondensierte heterocyclische verbindungen und deren analoga; modulatoren der funktion von nukleären hormonrezeptoren
DE10162375A1 (de) * 2001-12-19 2003-07-10 Bayer Ag Bicyclische N-Aryl-amide
JP2005523302A (ja) * 2002-03-18 2005-08-04 ファルマシア・コーポレーション アルドステロン受容体アンタゴニストおよびフィブリン酸誘導体の併用
US7405234B2 (en) 2002-05-17 2008-07-29 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
BR0313405A (pt) 2002-08-12 2005-07-12 Takeda Pharmaceutical Compostos, métodos para preparar um composto e para prevenir e/ou tratar câncer, prodroga, medicamento, modulador do receptor de androgênio, agente para prevenir e/ou tratar hipogonadismo ou pertubação climatérica masculina, osteoporose e câncer, e, uso de um composto
US7632858B2 (en) 2002-11-15 2009-12-15 Bristol-Myers Squibb Company Open chain prolyl urea-related modulators of androgen receptor function
US7199125B2 (en) 2003-10-02 2007-04-03 Bristol-Myers Squibb Company Spiro-cyclic compounds useful as anti-inflammatory agents
US7820702B2 (en) 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
US7417040B2 (en) 2004-03-01 2008-08-26 Bristol-Myers Squibb Company Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US7625923B2 (en) 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
US8546451B2 (en) 2005-11-28 2013-10-01 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US9409856B2 (en) 2005-11-28 2016-08-09 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
ES2377667T3 (es) * 2006-02-10 2012-03-29 Janssen Pharmaceutica N.V. Heterociclos de imidazol bicíclico o de tiadiazol útiles como moduladores selectivos de receptores de andrógenos
EP2039695A4 (fr) 2006-07-11 2010-09-15 Takeda Pharmaceutical Composé hétérocyclique bicycique et son utilisation
AU2009286528B2 (en) 2008-08-29 2014-07-17 Msd Italia S.R.L. Saturated bicyclic heterocyclic derivatives as Smo antagonists
US9427418B2 (en) 2009-02-23 2016-08-30 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US9624161B2 (en) 2009-02-23 2017-04-18 Gtx, Inc. Estrogen receptor ligands and methods of use thereof

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EP1043325B1 (fr) * 1994-12-22 2004-06-16 Ligand Pharmaceuticals Incorporated Composés modulateurs des récepteurs des stéroides et procédés d'utilisations
JP2000513362A (ja) * 1996-06-27 2000-10-10 リガンド・ファーマスーティカルス・インコーポレーテッド アンドロゲン受容体モジュレーター化合物及び方法
BR0111298A (pt) * 2000-06-28 2005-05-10 Bristol Myers Squibb Co Moduladores seletivos dos receptores de andrógenos e métodos para identificação, projeto e uso dos mesmos

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HUP0303165A2 (hu) 2003-12-29
NO20026167L (no) 2002-12-20
WO2002000653A2 (fr) 2002-01-03
JP2004515462A (ja) 2004-05-27
BR0111869A (pt) 2003-09-23
NO20026167D0 (no) 2002-12-20
WO2002000653A3 (fr) 2002-07-25
MXPA02012563A (es) 2003-05-14
HUP0303165A3 (en) 2006-05-29
AU2002215609A1 (en) 2002-01-08
EP1299385A2 (fr) 2003-04-09
NZ523802A (en) 2005-11-25

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