CA2413683A1 - Modulateurs cycliques condenses de la fonction du recepteur hormonal nucleaire - Google Patents

Modulateurs cycliques condenses de la fonction du recepteur hormonal nucleaire Download PDF

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Publication number
CA2413683A1
CA2413683A1 CA002413683A CA2413683A CA2413683A1 CA 2413683 A1 CA2413683 A1 CA 2413683A1 CA 002413683 A CA002413683 A CA 002413683A CA 2413683 A CA2413683 A CA 2413683A CA 2413683 A1 CA2413683 A1 CA 2413683A1
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Prior art keywords
alpha
substituted
methanoimidazo
alkyl
dione
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CA002413683A
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Mark E. Salvati
James Aaron Balog
Weifang Shan
Soren Giese
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Bristol Myers Squibb Co
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Individual
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pregnancy & Childbirth (AREA)

Abstract

L'invention concerne des composés cycliques condensés, des procédés d'utilisation de tels composés dans le traitement d'états associés au récepteur hormonal nucléaire, tels que le cancer et les troubles immuns, ainsi que des compositions pharmaceutiques contenant de tels composés.
CA002413683A 2000-06-28 2001-06-20 Modulateurs cycliques condenses de la fonction du recepteur hormonal nucleaire Abandoned CA2413683A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US21439200P 2000-06-28 2000-06-28
US60/214,392 2000-06-28
US28443801P 2001-04-18 2001-04-18
US28461701P 2001-04-18 2001-04-18
US60/284,617 2001-04-18
US60/284,438 2001-04-18
PCT/US2001/019663 WO2002000653A2 (fr) 2000-06-28 2001-06-20 Modulateurs cycliques condenses de la fonction du recepteur hormonal nucleaire

Publications (1)

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CA2413683A1 true CA2413683A1 (fr) 2002-01-03

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CA002413683A Abandoned CA2413683A1 (fr) 2000-06-28 2001-06-20 Modulateurs cycliques condenses de la fonction du recepteur hormonal nucleaire

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EP (1) EP1299385A2 (fr)
JP (1) JP2004515462A (fr)
AU (1) AU2002215609A1 (fr)
BR (1) BR0111869A (fr)
CA (1) CA2413683A1 (fr)
HU (1) HUP0303165A3 (fr)
MX (1) MXPA02012563A (fr)
NO (1) NO20026167L (fr)
NZ (1) NZ523802A (fr)
WO (1) WO2002000653A2 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000264876A (ja) * 1998-09-10 2000-09-26 Sumitomo Chem Co Ltd 縮合複素環化合物
JP2004509072A (ja) 2000-06-28 2004-03-25 ブリストル−マイヤーズ　スクイブ　カンパニー 選択的アンドロゲン受容体モジュレーター並びにその同定、設計及び使用方法
US7001911B2 (en) 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
US20030114420A1 (en) * 2000-06-28 2003-06-19 Salvati Mark E. Fused cyclic modulators of nuclear hormone receptor function
US20040077605A1 (en) 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
JP2004508373A (ja) * 2000-09-07 2004-03-18 バイエル・フアーマシユーチカルズ・コーポレーシヨン 環式および非環式アミジンおよびプロゲステロン受容体結合剤として使用するためのそれらを含有する医薬組成物
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
DE10162375A1 (de) * 2001-12-19 2003-07-10 Bayer Ag Bicyclische N-Aryl-amide
AU2002364082A1 (en) * 2001-12-19 2003-07-09 Bristol-Myers Squibb Company Fused heterocyclic compounds and analogs thereof: modulators of nuclear hormone receptor function
KR20040107482A (ko) * 2002-03-18 2004-12-20 파마시아 코포레이션 알도스테론 수용체 길항물질 및 피브르산 유도체의 혼합물
US7405234B2 (en) 2002-05-17 2008-07-29 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
MXPA05001631A (es) 2002-08-12 2005-08-19 Takeda Pharmaceutical Derivado de benceno fusionado y su uso.
EP1567487A4 (fr) 2002-11-15 2005-11-16 Bristol Myers Squibb Co Modulateurs lies a prolyl uree a chaine ouverte de la fonction du recepteur d'androgene
US7199125B2 (en) 2003-10-02 2007-04-03 Bristol-Myers Squibb Company Spiro-cyclic compounds useful as anti-inflammatory agents
US7820702B2 (en) 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
US7417040B2 (en) 2004-03-01 2008-08-26 Bristol-Myers Squibb Company Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US7625923B2 (en) 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
US8546451B2 (en) 2005-11-28 2013-10-01 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US9409856B2 (en) 2005-11-28 2016-08-09 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
WO2007095423A1 (fr) * 2006-02-10 2007-08-23 Janssen Pharmaceutica N.V. Imidazole ou thiadiazole bicyclique servant de modulateur selectif de recepteur d'androgene
EP2039695A4 (fr) 2006-07-11 2010-09-15 Takeda Pharmaceutical Composé hétérocyclique bicycique et son utilisation
EP2334683B1 (fr) 2008-08-29 2017-03-22 MSD Italia S.r.l. Dérivés hétérocycliques bicycliques saturés en tant qu antagonistes de smo
US9427418B2 (en) 2009-02-23 2016-08-30 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US9624161B2 (en) 2009-02-23 2017-04-18 Gtx, Inc. Estrogen receptor ligands and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996019458A2 (fr) * 1994-12-22 1996-06-27 Ligand Pharmaceuticals Incorporated Composes modulateurs des recepteurs des steroides et procedes d'utilisation
AU728178B2 (en) * 1996-06-27 2001-01-04 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
JP2004509072A (ja) * 2000-06-28 2004-03-25 ブリストル−マイヤーズ　スクイブ　カンパニー 選択的アンドロゲン受容体モジュレーター並びにその同定、設計及び使用方法

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JP2004515462A (ja) 2004-05-27
WO2002000653A3 (fr) 2002-07-25
NO20026167D0 (no) 2002-12-20
HUP0303165A2 (hu) 2003-12-29
EP1299385A2 (fr) 2003-04-09
AU2002215609A1 (en) 2002-01-08
NO20026167L (no) 2002-12-20
NZ523802A (en) 2005-11-25
MXPA02012563A (es) 2003-05-14
WO2002000653A2 (fr) 2002-01-03
HUP0303165A3 (en) 2006-05-29
BR0111869A (pt) 2003-09-23

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