CA2425186A1 - Expression, preparation, utilisations et sequence de la proteine hla-g soluble derivee par recombinaison - Google Patents
Expression, preparation, utilisations et sequence de la proteine hla-g soluble derivee par recombinaison Download PDFInfo
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- CA2425186A1 CA2425186A1 CA002425186A CA2425186A CA2425186A1 CA 2425186 A1 CA2425186 A1 CA 2425186A1 CA 002425186 A CA002425186 A CA 002425186A CA 2425186 A CA2425186 A CA 2425186A CA 2425186 A1 CA2425186 A1 CA 2425186A1
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- recombinant protein
- seq
- sequence
- amino acid
- acid sequence
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Cette invention se rapporte à des procédés pour produire et utiliser la protéine HLA-G soluble recombinée. Cette protéine HLA-G soluble recombinée modifie les réactions immunitaires contre les tissus, les organes, les foetus et les embryons qui sont génétiquement distincts de l'organisme recevant ou possédant un tel matériau antigénique. Des formes préférées de cette protéine contiennent des séquences possédant une homologie de séquence d'au moins 70 % avec des formes naturelles de HLA-G. Plus spécifiquement, chaque forme recombinée de HLA-G produite et utilisée par les procédés faisant l'objet de cette invention doit contenir une séquence possédant une homologie de séquence d'au moins 70 % avec l'intron 4 exprimé par le gène HLA-G et au moins une séquence possédant une homologie de séquence d'au moins 70 % avec l'un des domaines .alpha. exprimés par le gène HLA-G. Des formes préférées de cette invention contiennent une isoforme qui contient le domaine .alpha.1, le domaine .alpha.2, le domaine .alpha.3 et l'intron 4, et une seconde isoforme qui contient le domaine .alpha.1, le domaine .alpha.3 et l'intron 4. Plus préférablement, ces séquences contiennent une séquence peptidique d'aide à la purification et un peptide signal.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23276100P | 2000-09-15 | 2000-09-15 | |
| US60/232,761 | 2000-09-15 | ||
| PCT/US2001/029228 WO2002022784A2 (fr) | 2000-09-15 | 2001-09-17 | Expression, preparation, utilisations et sequence de la proteine hla-g soluble derivee par recombinaison |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2425186A1 true CA2425186A1 (fr) | 2002-03-21 |
Family
ID=22874459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002425186A Abandoned CA2425186A1 (fr) | 2000-09-15 | 2001-09-17 | Expression, preparation, utilisations et sequence de la proteine hla-g soluble derivee par recombinaison |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1328290A2 (fr) |
| AU (1) | AU2001292773A1 (fr) |
| CA (1) | CA2425186A1 (fr) |
| WO (1) | WO2002022784A2 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007011044A1 (fr) * | 2005-07-15 | 2007-01-25 | Kyushu University, National University Corporation | Composition pharmaceutique comprenant un dimere hla-g lie disulfide et procede de fabrication de ce dimere hla-g lie disulfide |
| EP2184297A1 (fr) * | 2008-11-07 | 2010-05-12 | Hla-G Technologies | Polypeptides HLA-G et leurs utilisations pharmaceutiques |
| EP2264067A1 (fr) * | 2009-06-18 | 2010-12-22 | Hla-G Technologies | Multimères de HLA-G alpha 1 et leurs utilisations pharmaceutiques |
| CN102574905A (zh) * | 2009-06-18 | 2012-07-11 | Hla-G科技公司 | HLA-Gα1多聚体及其药学用途 |
| EP2730588A1 (fr) | 2012-11-12 | 2014-05-14 | Intelectys | Anticorps et fragments de ceux-ci dirigés contre le domaine alpha-3 de protéine HLA-G, procédés et moyens pour leur préparation et leurs utilisations |
| TW201829463A (zh) | 2016-11-18 | 2018-08-16 | 瑞士商赫孚孟拉羅股份公司 | 抗hla-g抗體及其用途 |
| AR114789A1 (es) | 2018-04-18 | 2020-10-14 | Hoffmann La Roche | Anticuerpos anti-hla-g y uso de los mismos |
| US11208487B2 (en) | 2018-09-27 | 2021-12-28 | Tizona Therapeutics | Anti-HLA-G antibodies, compositions comprising anti-HLA-G antibodies and methods of using anti-HLA-G antibodies |
| MX2023007133A (es) | 2020-12-17 | 2023-06-27 | Hoffmann La Roche | Anticuerpos anti-hla-g y uso de estos. |
-
2001
- 2001-09-17 CA CA002425186A patent/CA2425186A1/fr not_active Abandoned
- 2001-09-17 EP EP01973167A patent/EP1328290A2/fr not_active Ceased
- 2001-09-17 WO PCT/US2001/029228 patent/WO2002022784A2/fr not_active Ceased
- 2001-09-17 AU AU2001292773A patent/AU2001292773A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001292773A1 (en) | 2002-03-26 |
| WO2002022784A2 (fr) | 2002-03-21 |
| EP1328290A2 (fr) | 2003-07-23 |
| WO2002022784A3 (fr) | 2002-06-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |