CA2425368A1 - New sulphoxybenzamides - Google Patents

New sulphoxybenzamides Download PDF

Info

Publication number
CA2425368A1
CA2425368A1 CA002425368A CA2425368A CA2425368A1 CA 2425368 A1 CA2425368 A1 CA 2425368A1 CA 002425368 A CA002425368 A CA 002425368A CA 2425368 A CA2425368 A CA 2425368A CA 2425368 A1 CA2425368 A1 CA 2425368A1
Authority
CA
Canada
Prior art keywords
represent
independent
another
groups
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002425368A
Other languages
French (fr)
Other versions
CA2425368C (en
Inventor
Ralf Anderskewitz
Kurt Schromm
Franz Birke
Hans Michael Jennewein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2425368A1 publication Critical patent/CA2425368A1/en
Application granted granted Critical
Publication of CA2425368C publication Critical patent/CA2425368C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/22—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings
    • C07C305/24—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The invention relates to novel sulfoxybenzamides of formula (I), wherein: Z0 represents a group selected among formulas -X1-(CH2)r-X2- and -CR4R5-; A1 an d A2, independent of one another, represent a 1,4-phenylene group or 1,3- phenylene group optionally substituted by one or more halogen atoms, C1-C8 alkyl groups, C2-C8 alkenyl groups, C1-C8 alkyl halide groups or by C1-C8 alkoxy groups; Z1 and Z2, independent of one another, represent a group of formula -X3-(CH2)8-X4- or a single bond; m and n, independent of one another , represent 0 or 1, and; radicals R1, R2, R3, R4, R5, X1, X2, X3, X4, r and s have the meanings cited in the description. The invention also relates to a method for producing these novel compounds and to their use as medicaments, especially as leukotriene B4(LTB4) antagonists.
CA002425368A 2000-10-24 2001-10-19 New sulphoxybenzamides Expired - Fee Related CA2425368C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10052333A DE10052333A1 (en) 2000-10-24 2000-10-24 New sulfooxybenzamides
DE10052333.1 2000-10-24
PCT/EP2001/012127 WO2002034715A1 (en) 2000-10-24 2001-10-19 Benzamidine derivatives comprising a sulfate group serving as ltb4 antagonists

Publications (2)

Publication Number Publication Date
CA2425368A1 true CA2425368A1 (en) 2003-04-08
CA2425368C CA2425368C (en) 2008-12-09

Family

ID=7660637

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002425368A Expired - Fee Related CA2425368C (en) 2000-10-24 2001-10-19 New sulphoxybenzamides

Country Status (8)

Country Link
EP (1) EP1332128A1 (en)
JP (1) JP3917516B2 (en)
AU (1) AU2002210558A1 (en)
CA (1) CA2425368C (en)
DE (1) DE10052333A1 (en)
MX (1) MXPA03003465A (en)
PE (1) PE20020542A1 (en)
WO (1) WO2002034715A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7262223B2 (en) 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
CN101022796B (en) * 2004-07-14 2013-02-27 炎症研究中心有限公司 Method for inhibiting tumor metastasis
ATE460173T1 (en) * 2005-07-08 2010-03-15 Leopold Franzens Uni Innsbruck USE OF EXTRACTS AND INGREDIENTS FROM LEONTOPODIUM TO INCREASE CHOLINERGIC FUNCTION
CN100402494C (en) * 2005-08-25 2008-07-16 江苏吴中苏药医药开发有限责任公司 Myoinositol sulfate aluminium , its preparation method and oral compositions and uses
CN103492365A (en) 2011-03-16 2014-01-01 创新治疗有限公司 Substituted diphenyl derivatives
WO2018207950A1 (en) 2017-05-12 2018-11-15 横山　茂之 Class a gpcr-binding compound modifier

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2124002C1 (en) * 1992-02-05 1998-12-27 Берингер Ингельхейм КГ Amidine derivatives, mixture of their isomers or separate isomers and salts, pharmaceutical composition showing antagonistic effect with respect to leukotriene-b4
DE19546452A1 (en) * 1995-12-13 1997-06-19 Boehringer Ingelheim Kg New phenylamidine derivatives, process for their preparation and their use as medicaments
DE19636689A1 (en) * 1996-09-10 1998-03-12 Boehringer Ingelheim Kg New benzamidine derivatives

Also Published As

Publication number Publication date
MXPA03003465A (en) 2004-12-06
AU2002210558A1 (en) 2002-05-06
JP2004512322A (en) 2004-04-22
DE10052333A1 (en) 2002-05-02
PE20020542A1 (en) 2002-07-16
CA2425368C (en) 2008-12-09
WO2002034715A1 (en) 2002-05-02
JP3917516B2 (en) 2007-05-23
EP1332128A1 (en) 2003-08-06

Similar Documents

Publication Publication Date Title
AU4306796A (en) Novel 3,5-dioxo-(2h,4h)-1,2,4-triazine derivatives, their preparation and use as drugs
GB2365430B (en) Acylphosphine photoinitiators and intermediates
BG106340A (en) Substituted oxoazaheterocyclyl compounds
SE0103836D0 (en) Novel compounds
YU40997A (en) New oxadiazoles, processes for their preparation
ATE316083T1 (en) ADAMANTANDE DERIVATIVES
MXPA02011370A (en) Substituted iminoazines.
WO2004048340A8 (en) Sinomenine and sinomenine compounds, synthesis and use
MXPA02004448A (en) Imidazopyridine derivatives as phosphodiesterase vii inhibitors.
EP0996037A3 (en) Polyvinyl acetals having imido groups and use thereof in photosensitive compositions
PL345448A1 (en) Substituted phenyl uracils
MY145079A (en) 1-substituted-4-nitroimidazole compound and method for preparing the same
CA2425368A1 (en) New sulphoxybenzamides
AP2001002188A0 (en) 5HT1 antagonists for antidepressant therapy.
BG104232A (en) Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ol, a method for their preparation and their use as medicaments
TR200402546T4 (en) Process for preparing taxane derivatives.
IT1293777B1 (en) PROCESS FOR THE PREPARATION OF TETRAAZAMACROCYCLES
SE9904128D0 (en) Novel compounds
AU6876896A (en) Carbamoylcarboxamides
GB9806409D0 (en) Processes for preparing intermediates
CA2337586A1 (en) Alkylation process and novel hydroxyphenylbenztriazoles
WO2001051486A3 (en) Process and intermediates for the preparation of imidazopyridines
MY128754A (en) Substituted 3-aryl-3-carboxyalkyl glutaramides, method for preparing same by 4-aryl-4-cyanoheptane dicarboxylic acid cyclisation, and use thereof for preparing 3-aryl-3-hydroxyalkylpiperidines
TW200504159A (en) Monoazo compound and process for making same
AU2003256091A1 (en) 1,2,4-triazole derivative, method for preparing the same, and pharmaceutical composition containing the same

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed