CA2425368A1 - New sulphoxybenzamides - Google Patents

New sulphoxybenzamides Download PDF

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Publication number
CA2425368A1
CA2425368A1 CA002425368A CA2425368A CA2425368A1 CA 2425368 A1 CA2425368 A1 CA 2425368A1 CA 002425368 A CA002425368 A CA 002425368A CA 2425368 A CA2425368 A CA 2425368A CA 2425368 A1 CA2425368 A1 CA 2425368A1
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Canada
Prior art keywords
represent
independent
another
groups
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002425368A
Other languages
French (fr)
Other versions
CA2425368C (en
Inventor
Ralf Anderskewitz
Kurt Schromm
Franz Birke
Hans Michael Jennewein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
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Individual
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Publication of CA2425368A1 publication Critical patent/CA2425368A1/en
Application granted granted Critical
Publication of CA2425368C publication Critical patent/CA2425368C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/22—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings
    • C07C305/24—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The invention relates to novel sulfoxybenzamides of formula (I), wherein: Z0 represents a group selected among formulas -X1-(CH2)r-X2- and -CR4R5-; A1 an d A2, independent of one another, represent a 1,4-phenylene group or 1,3- phenylene group optionally substituted by one or more halogen atoms, C1-C8 alkyl groups, C2-C8 alkenyl groups, C1-C8 alkyl halide groups or by C1-C8 alkoxy groups; Z1 and Z2, independent of one another, represent a group of formula -X3-(CH2)8-X4- or a single bond; m and n, independent of one another , represent 0 or 1, and; radicals R1, R2, R3, R4, R5, X1, X2, X3, X4, r and s have the meanings cited in the description. The invention also relates to a method for producing these novel compounds and to their use as medicaments, especially as leukotriene B4(LTB4) antagonists.
CA002425368A 2000-10-24 2001-10-19 New sulphoxybenzamides Expired - Fee Related CA2425368C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10052333.1 2000-10-24
DE10052333A DE10052333A1 (en) 2000-10-24 2000-10-24 New sulfooxybenzamides
PCT/EP2001/012127 WO2002034715A1 (en) 2000-10-24 2001-10-19 Benzamidine derivatives comprising a sulfate group serving as ltb4 antagonists

Publications (2)

Publication Number Publication Date
CA2425368A1 true CA2425368A1 (en) 2003-04-08
CA2425368C CA2425368C (en) 2008-12-09

Family

ID=7660637

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002425368A Expired - Fee Related CA2425368C (en) 2000-10-24 2001-10-19 New sulphoxybenzamides

Country Status (8)

Country Link
EP (1) EP1332128A1 (en)
JP (1) JP3917516B2 (en)
AU (1) AU2002210558A1 (en)
CA (1) CA2425368C (en)
DE (1) DE10052333A1 (en)
MX (1) MXPA03003465A (en)
PE (1) PE20020542A1 (en)
WO (1) WO2002034715A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7262223B2 (en) 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
CN101022796B (en) * 2004-07-14 2013-02-27 炎症研究中心有限公司 Method for inhibiting tumor metastasis
DE602005019897D1 (en) * 2005-07-08 2010-04-22 Leopold Franzens Uni Innsbruck Use of extracts and ingredients from Leontopodium to increase cholinergic function
CN100402494C (en) * 2005-08-25 2008-07-16 江苏吴中苏药医药开发有限责任公司 Myoinositol sulfate aluminium , its preparation method and oral compositions and uses
JP2014515734A (en) 2011-03-16 2014-07-03 クリエイティブ セラポーティクス ゲーエムベーハー Substituted diphenyl derivatives
WO2018207950A1 (en) 2017-05-12 2018-11-15 横山　茂之 Class a gpcr-binding compound modifier

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2129526A1 (en) * 1992-02-05 1993-08-06 Franz Birke Novel amidine derivatives, their preparation and their use as medicaments with ltb4 antagonistic effect
DE19546452A1 (en) * 1995-12-13 1997-06-19 Boehringer Ingelheim Kg New phenylamidine derivatives, process for their preparation and their use as medicaments
DE19636689A1 (en) * 1996-09-10 1998-03-12 Boehringer Ingelheim Kg New benzamidine derivatives

Also Published As

Publication number Publication date
DE10052333A1 (en) 2002-05-02
AU2002210558A1 (en) 2002-05-06
JP3917516B2 (en) 2007-05-23
JP2004512322A (en) 2004-04-22
EP1332128A1 (en) 2003-08-06
MXPA03003465A (en) 2004-12-06
WO2002034715A1 (en) 2002-05-02
CA2425368C (en) 2008-12-09
PE20020542A1 (en) 2002-07-16

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