CA2425368A1 - Nouveaux sulphoxybenzamides - Google Patents

Nouveaux sulphoxybenzamides Download PDF

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Publication number
CA2425368A1
CA2425368A1 CA002425368A CA2425368A CA2425368A1 CA 2425368 A1 CA2425368 A1 CA 2425368A1 CA 002425368 A CA002425368 A CA 002425368A CA 2425368 A CA2425368 A CA 2425368A CA 2425368 A1 CA2425368 A1 CA 2425368A1
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Canada
Prior art keywords
represent
independent
another
groups
formula
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Granted
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CA002425368A
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English (en)
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CA2425368C (fr
Inventor
Ralf Anderskewitz
Kurt Schromm
Franz Birke
Hans Michael Jennewein
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Boehringer Ingelheim Pharma GmbH and Co KG
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Individual
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Publication of CA2425368A1 publication Critical patent/CA2425368A1/fr
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Publication of CA2425368C publication Critical patent/CA2425368C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/22—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings
    • C07C305/24—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La présente invention concerne de nouveaux sulfooxybenzamides de la formule (I) dans laquelle Z<0> est un groupe choisi parmi les formules -X<1>-(CH2)r-X<2>- et -CR<4>R<5>- ; A<1> et A<2> sont indépendamment l'un de l'autre des groupes 1,4-phénylène ou 1,3-phénylène éventuellements substitués par un ou plusieurs atomes halogène, des groupes C1-C8-alkyl, des groupes C2-C8-alcényl, des groupes C1-C8-haloalkyl ou des groupes C1-C8-alkoxy, Z<1> et Z<2> sont indépendamment l'un de l'autre un groupe de formule -X<3>-(CH2)8-X<4>- ou une liaison simple ; et, m et n sont indépendamment l'un de l'autre 0 ou 1, les restes R<1>, R<2>, R<3>, R<4>, R<5>, X<1>, X<2>, X<3>, X<4>, r et s ayant la signification donnée dans le descriptif. L'invention concerne également des procédés de fabrication des composés selon l'invention, et leur utilisation en tant qu'agents pharmaceutiques, en particulier en tant qu'antagonistes de leucotriène B4(LTB4).
CA002425368A 2000-10-24 2001-10-19 Nouveaux sulphoxybenzamides Expired - Fee Related CA2425368C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10052333A DE10052333A1 (de) 2000-10-24 2000-10-24 Neue Sulfooxybenzamide
DE10052333.1 2000-10-24
PCT/EP2001/012127 WO2002034715A1 (fr) 2000-10-24 2001-10-19 Derives benzamidine comportant un groupe sulfate, servant d'antagonistes de ltb4

Publications (2)

Publication Number Publication Date
CA2425368A1 true CA2425368A1 (fr) 2003-04-08
CA2425368C CA2425368C (fr) 2008-12-09

Family

ID=7660637

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002425368A Expired - Fee Related CA2425368C (fr) 2000-10-24 2001-10-19 Nouveaux sulphoxybenzamides

Country Status (8)

Country Link
EP (1) EP1332128A1 (fr)
JP (1) JP3917516B2 (fr)
AU (1) AU2002210558A1 (fr)
CA (1) CA2425368C (fr)
DE (1) DE10052333A1 (fr)
MX (1) MXPA03003465A (fr)
PE (1) PE20020542A1 (fr)
WO (1) WO2002034715A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7262223B2 (en) 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
CN101022796B (zh) * 2004-07-14 2013-02-27 炎症研究中心有限公司 抑制肿瘤转移的方法
ATE460173T1 (de) * 2005-07-08 2010-03-15 Leopold Franzens Uni Innsbruck Verwendung von extrakten und inhaltsstoffen aus leontopodium zur steigerung der cholinergen funktion
CN100402494C (zh) * 2005-08-25 2008-07-16 江苏吴中苏药医药开发有限责任公司 肌醇硫酸酯铝及其制备方法和口服组合物、应用
CN103492365A (zh) 2011-03-16 2014-01-01 创新治疗有限公司 取代的联苯衍生物
WO2018207950A1 (fr) 2017-05-12 2018-11-15 横山　茂之 Modificateur de composé de liaison de gpcr de classe a

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2124002C1 (ru) * 1992-02-05 1998-12-27 Берингер Ингельхейм КГ Производные амидина, смесь их изомеров или отдельные изомеры и их соли, фармацевтическая композиция, обладающая антагонистическим действием в отношении лейкотриена b4
DE19546452A1 (de) * 1995-12-13 1997-06-19 Boehringer Ingelheim Kg Neue Phenylamidinderivate, Verfahren zu ihrer Herstelung und ihre Verwendung als Arzneimittel
DE19636689A1 (de) * 1996-09-10 1998-03-12 Boehringer Ingelheim Kg Neue Benzamidinderivate

Also Published As

Publication number Publication date
MXPA03003465A (es) 2004-12-06
AU2002210558A1 (en) 2002-05-06
JP2004512322A (ja) 2004-04-22
DE10052333A1 (de) 2002-05-02
PE20020542A1 (es) 2002-07-16
CA2425368C (fr) 2008-12-09
WO2002034715A1 (fr) 2002-05-02
JP3917516B2 (ja) 2007-05-23
EP1332128A1 (fr) 2003-08-06

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