CA2430531C - Spectrometre de masse - Google Patents
Spectrometre de masse Download PDFInfo
- Publication number
- CA2430531C CA2430531C CA2430531A CA2430531A CA2430531C CA 2430531 C CA2430531 C CA 2430531C CA 2430531 A CA2430531 A CA 2430531A CA 2430531 A CA2430531 A CA 2430531A CA 2430531 C CA2430531 C CA 2430531C
- Authority
- CA
- Canada
- Prior art keywords
- ion guide
- ions
- mass spectrometer
- ion
- equal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000002500 ions Chemical class 0.000 claims abstract description 613
- 238000005040 ion trap Methods 0.000 claims abstract description 18
- 230000001360 synchronised effect Effects 0.000 claims abstract description 14
- 230000001052 transient effect Effects 0.000 claims description 84
- 230000007423 decrease Effects 0.000 claims description 34
- 238000005036 potential barrier Methods 0.000 claims description 15
- 230000004888 barrier function Effects 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 230000004323 axial length Effects 0.000 claims description 10
- 238000004949 mass spectrometry Methods 0.000 claims description 7
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims description 6
- 230000005540 biological transmission Effects 0.000 claims description 5
- 238000010265 fast atom bombardment Methods 0.000 claims description 4
- 238000009616 inductively coupled plasma Methods 0.000 claims description 4
- 238000011144 upstream manufacturing Methods 0.000 claims description 4
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims description 2
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 claims description 2
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims description 2
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 2
- 238000000451 chemical ionisation Methods 0.000 claims description 2
- 230000005684 electric field Effects 0.000 claims description 2
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 238000001698 laser desorption ionisation Methods 0.000 claims 2
- 230000001133 acceleration Effects 0.000 abstract description 16
- 239000007789 gas Substances 0.000 description 28
- 238000004804 winding Methods 0.000 description 12
- 238000001514 detection method Methods 0.000 description 8
- 230000008901 benefit Effects 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- 238000013467 fragmentation Methods 0.000 description 4
- 238000006062 fragmentation reaction Methods 0.000 description 4
- 238000010884 ion-beam technique Methods 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 230000005405 multipole Effects 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 230000010363 phase shift Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000004252 FT/ICR mass spectrometry Methods 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/065—Ion guides having stacked electrodes, e.g. ring stack, plate stack
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
La présente divulgation décrit un spectromètre de masse pourvu d'un guide à ions (1) qui reçoit des ions d'une source d'ions pulsée ou d'un piège à ions, ou bien d'une source d'ions continue. Le guide à ions (1) émet un paquets d'ions. Les impulsions d'ions émises du guide à ions (1) peuvent être synchronisées sur un autre dispositif, comme un détecteur d'ions, un analyseur de masse à temps de vol à accélération orthogonale, un piège à ions ou un filtre de masse.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0212508A GB0212508D0 (en) | 2002-05-30 | 2002-05-30 | Mass spectrometer |
| GB0212508.6 | 2002-05-30 | ||
| GB0308411A GB0308411D0 (en) | 2002-05-30 | 2003-04-11 | Mass spectrometer |
| GB0308411.8 | 2003-04-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2430531A1 CA2430531A1 (fr) | 2003-11-30 |
| CA2430531C true CA2430531C (fr) | 2012-01-10 |
Family
ID=26247074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2430531A Expired - Lifetime CA2430531C (fr) | 2002-05-30 | 2003-05-30 | Spectrometre de masse |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1367633B1 (fr) |
| AT (1) | ATE339011T1 (fr) |
| CA (1) | CA2430531C (fr) |
| DE (1) | DE60308096T2 (fr) |
| GB (1) | GB2391697B (fr) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7071467B2 (en) | 2002-08-05 | 2006-07-04 | Micromass Uk Limited | Mass spectrometer |
| GB2400488B (en) * | 2002-08-05 | 2005-02-23 | Micromass Ltd | Mass spectrometer |
| GB0514964D0 (en) | 2005-07-21 | 2005-08-24 | Ms Horizons Ltd | Mass spectrometer devices & methods of performing mass spectrometry |
| GB0416288D0 (en) * | 2004-07-21 | 2004-08-25 | Micromass Ltd | Mass spectrometer |
| GB0426900D0 (en) | 2004-12-08 | 2005-01-12 | Micromass Ltd | Mass spectrometer |
| CA2595631C (fr) * | 2005-01-17 | 2014-04-22 | Micromass Uk Limited | Spectrometre de masse |
| DE102005021836A1 (de) * | 2005-05-11 | 2006-11-16 | Geoforschungszentrum Potsdam | Verfahren und Vorrichtung zum massenselektiven Ionentransport |
| GB0511333D0 (en) * | 2005-06-03 | 2005-07-13 | Micromass Ltd | Mass spectrometer |
| DE102006016896B4 (de) * | 2006-04-11 | 2009-06-10 | Bruker Daltonik Gmbh | Orthogonal-Flugzeitmassenspektrometer geringer Massendiskriminierung |
| CA2656197C (fr) * | 2006-07-10 | 2015-06-16 | John Brian Hoyes | Spectrometre de masse |
| DE102006040000B4 (de) * | 2006-08-25 | 2010-10-28 | Bruker Daltonik Gmbh | Speicherbatterie für Ionen |
| GB0624993D0 (en) | 2006-12-14 | 2007-01-24 | Micromass Ltd | Mass spectrometer |
| GB201104665D0 (en) | 2011-03-18 | 2011-05-04 | Shimadzu Res Lab Europe Ltd | Ion analysis apparatus and methods |
| CN107658203B (zh) | 2011-05-05 | 2020-04-14 | 岛津研究实验室（欧洲）有限公司 | 操纵带电粒子的装置 |
| GB201117158D0 (en) * | 2011-10-05 | 2011-11-16 | Micromass Ltd | Ion guide |
| GB201118270D0 (en) | 2011-10-21 | 2011-12-07 | Shimadzu Corp | TOF mass analyser with improved resolving power |
| EP3892990A1 (fr) | 2013-03-06 | 2021-10-13 | Micromass UK Limited | Échelles de séparation de mobilité d'ions optimisées pour ions ciblés |
| US9552970B2 (en) | 2013-03-06 | 2017-01-24 | Micromass Uk Limited | Time shift for improved ion mobility spectrometry or separation digitisation |
| GB201304037D0 (en) * | 2013-03-06 | 2013-04-17 | Micromass Ltd | Optimised ion mobility separation timescales for targeted ions |
| GB201304039D0 (en) * | 2013-03-06 | 2013-04-17 | Micromass Ltd | Time shift improved IMS digitisation |
| US9196467B2 (en) | 2013-03-11 | 2015-11-24 | 1St Detect Corporation | Mass spectrum noise cancellation by alternating inverted synchronous RF |
| GB201621587D0 (en) * | 2016-12-19 | 2017-02-01 | Shimadzu Corp | A transport device for transporting charged particles |
| EP3561853A1 (fr) | 2018-04-26 | 2019-10-30 | Tofwerk AG | Ensemble de guide d'ions |
| US12089932B2 (en) | 2018-06-05 | 2024-09-17 | Trace Matters Scientific Llc | Apparatus, system, and method for transferring ions |
| GB201819372D0 (en) | 2018-11-28 | 2019-01-09 | Shimadzu Corp | Apparatus for analysing ions |
| US11114290B1 (en) | 2020-05-07 | 2021-09-07 | Thermo Finnigan Llc | Ion funnels and systems incorporating ion funnels |
| US11581179B2 (en) | 2020-05-07 | 2023-02-14 | Thermo Finnigan Llc | Ion funnels and systems incorporating ion funnels |
| US11605532B2 (en) | 2021-05-27 | 2023-03-14 | Tofwerk Ag | Method and ion guide assembly for modulating a stream of ions |
| EP4095525B1 (fr) | 2021-05-27 | 2024-12-18 | Tofwerk AG | Procédé et ensemble de guide d'ions pour moduler un flux d'ions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206506A (en) * | 1991-02-12 | 1993-04-27 | Kirchner Nicholas J | Ion processing: control and analysis |
| US6011259A (en) * | 1995-08-10 | 2000-01-04 | Analytica Of Branford, Inc. | Multipole ion guide ion trap mass spectrometry with MS/MSN analysis |
| DE19628179C2 (de) * | 1996-07-12 | 1998-04-23 | Bruker Franzen Analytik Gmbh | Vorrichtung und Verfahren zum Einschuß von Ionen in eine Ionenfalle |
| CA2626383C (fr) * | 1998-05-29 | 2011-07-19 | Craig M. Whitehouse | Spectrometrie de masse avec guides d'ions multipolaires |
| EP1212778A2 (fr) * | 1999-08-26 | 2002-06-12 | University Of New Hampshire | Spectrometre de masse a plusieurs etapes |
| US6545268B1 (en) * | 2000-04-10 | 2003-04-08 | Perseptive Biosystems | Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis |
| GB2375653B (en) * | 2001-02-22 | 2004-11-10 | Bruker Daltonik Gmbh | Travelling field for packaging ion beams |
| CA2391140C (fr) * | 2001-06-25 | 2008-10-07 | Micromass Limited | Spectrometre de masse |
-
2003
- 2003-05-30 EP EP03253412A patent/EP1367633B1/fr not_active Expired - Lifetime
- 2003-05-30 DE DE60308096T patent/DE60308096T2/de not_active Expired - Lifetime
- 2003-05-30 CA CA2430531A patent/CA2430531C/fr not_active Expired - Lifetime
- 2003-05-30 AT AT03253412T patent/ATE339011T1/de not_active IP Right Cessation
- 2003-05-30 GB GB0312480A patent/GB2391697B/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1367633A2 (fr) | 2003-12-03 |
| GB2391697A (en) | 2004-02-11 |
| CA2430531A1 (fr) | 2003-11-30 |
| EP1367633A3 (fr) | 2004-06-23 |
| GB2391697B (en) | 2004-07-28 |
| EP1367633B1 (fr) | 2006-09-06 |
| GB0312480D0 (en) | 2003-07-09 |
| ATE339011T1 (de) | 2006-09-15 |
| DE60308096D1 (de) | 2006-10-19 |
| DE60308096T2 (de) | 2007-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20230530 |