CA2438501C - Cellules souches adultes totipotentes, sources de ces cellules, procedes d'obtention et de maintien de ces dernieres, procedes de differentiation de ces cellules, procedes d'utilisation correspondants et cellules derivees des cellules susmentionnees - Google Patents
Cellules souches adultes totipotentes, sources de ces cellules, procedes d'obtention et de maintien de ces dernieres, procedes de differentiation de ces cellules, procedes d'utilisation correspondants et cellules derivees des cellules susmentionnees Download PDFInfo
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- CA2438501C CA2438501C CA2438501A CA2438501A CA2438501C CA 2438501 C CA2438501 C CA 2438501C CA 2438501 A CA2438501 A CA 2438501A CA 2438501 A CA2438501 A CA 2438501A CA 2438501 C CA2438501 C CA 2438501C
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Abstract
L'invention se rapporte à des méthodes et à des compositions de circularisation de séquences cibles dans un échantillon. Plus précisément, des oligonucléotides à ligature sont employés afin d'être hybridés sélectivement avec la séquence cible de manière à ce que cette dernière puisse être ligaturée à l'intérieur d'une séquence cible circulaire fermée. L'amplification en cercle roulant peut alors être appliquée directement sur la séquence cible afin de procéder ultérieurement à la détection et à l'analyse.
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26878601P | 2001-02-14 | 2001-02-14 | |
| US60/268,786 | 2001-02-14 | ||
| US26906201P | 2001-02-15 | 2001-02-15 | |
| US60/269,062 | 2001-02-15 | ||
| US31062501P | 2001-08-07 | 2001-08-07 | |
| US60/310,625 | 2001-08-07 | ||
| US34338601P | 2001-10-25 | 2001-10-25 | |
| US60/343,836 | 2001-10-25 | ||
| PCT/US2002/004652 WO2002064748A2 (fr) | 2001-02-14 | 2002-02-14 | Cellules souches adultes totipotentes, sources de ces cellules, procedes d'obtention et de maintien de ces dernieres, procedes de differentiation de ces cellules, procedes d'utilisation correspondants et cellules derivees des cellules susmentionnees |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2438501A1 CA2438501A1 (fr) | 2002-08-22 |
| CA2438501C true CA2438501C (fr) | 2014-09-16 |
Family
ID=27500956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2438501A Expired - Lifetime CA2438501C (fr) | 2001-02-14 | 2002-02-14 | Cellules souches adultes totipotentes, sources de ces cellules, procedes d'obtention et de maintien de ces dernieres, procedes de differentiation de ces cellules, procedes d'utilisation correspondants et cellules derivees des cellules susmentionnees |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7838289B2 (fr) |
| EP (2) | EP1367899A4 (fr) |
| JP (1) | JP2004529621A (fr) |
| CA (1) | CA2438501C (fr) |
| IL (4) | IL157332A0 (fr) |
| WO (1) | WO2002064748A2 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU214445U1 (ru) * | 2022-07-21 | 2022-10-28 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Курская государственная сельскохозяйственная академия имени И.И. Иванова" | Универсальный зевник для животных |
Families Citing this family (169)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040242520A1 (en) * | 1997-09-06 | 2004-12-02 | Mayo Foundation For Medical Education And Research, A Minnesota Corporation | Expression of immonogenic substances |
| US8062675B2 (en) | 1999-07-07 | 2011-11-22 | Angioblast Systems, Inc. | Mesenchymal precursor cell |
| US7670628B2 (en) * | 1999-07-07 | 2010-03-02 | Angioblast Systems, Inc. | Mesenchymal precursor cell |
| AUPQ147799A0 (en) * | 1999-07-07 | 1999-07-29 | Medvet Science Pty. Ltd. | Mesenchymal precursor cell |
| AU2003901668A0 (en) * | 2003-03-28 | 2003-05-01 | Medvet Science Pty. Ltd. | Non-haemopoietic precursor cells |
| US20050158289A1 (en) * | 1999-07-07 | 2005-07-21 | Simmons Paul J. | Mesenchymal precursor cell and use thereof in the repair of bone defects and fractures in mammals |
| US8147824B2 (en) | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
| US10638734B2 (en) | 2004-01-05 | 2020-05-05 | Abt Holding Company | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
| US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| US8252280B1 (en) | 1999-08-05 | 2012-08-28 | Regents Of The University Of Minnesota | MAPC generation of muscle |
| US8609412B2 (en) | 1999-08-05 | 2013-12-17 | Regents Of The University Of Minnesota | Mapc generation of lung tissue |
| US7291597B2 (en) * | 2000-04-06 | 2007-11-06 | Franco Wayne P | Growth factor therapy mobilization of stem cells into the peripheral blood |
| US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| MXPA03005014A (es) | 2000-12-06 | 2004-09-10 | Robert J Hariri | Metodo para recolectar celulas madres de la placenta. |
| AU2002251935B2 (en) | 2001-02-14 | 2007-11-29 | Celularity Inc. | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| CA2438501C (fr) | 2001-02-14 | 2014-09-16 | Leo T. Furcht | Cellules souches adultes totipotentes, sources de ces cellules, procedes d'obtention et de maintien de ces dernieres, procedes de differentiation de ces cellules, procedes d'utilisation correspondants et cellules derivees des cellules susmentionnees |
| EP2338983B1 (fr) * | 2001-02-14 | 2015-10-07 | Anthrogenesis Corporation | Renovation et repeuplement de tissus decellularises er d'organes preleves sur des cadavres par des cellules souches. |
| DE10144326B4 (de) * | 2001-09-10 | 2005-09-22 | Siemens Ag | Verfahren und System zur Überwachung eines Reifenluftdrucks |
| US9969980B2 (en) * | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| WO2003060082A2 (fr) | 2002-01-14 | 2003-07-24 | The Board Of Trustees Of The University Of Illinois | Utilisation de composes de pyrimidine modifies pour promouvoir la migration et la proliferation de cellules souches |
| US20030228287A1 (en) * | 2002-06-07 | 2003-12-11 | Regents Of The University Of California | Maintenance of islet cells |
| US20040052771A1 (en) * | 2002-07-12 | 2004-03-18 | Lim Sai Kiang | Hemangioblast progenitor cells |
| AU2003248609A1 (en) * | 2002-07-12 | 2004-02-02 | Agency For Science, Technology And Research | Hemangioblast progenitor cells |
| US7422736B2 (en) * | 2002-07-26 | 2008-09-09 | Food Industry Research And Development Institute | Somatic pluripotent cells |
| AU2003250666A1 (en) * | 2002-07-29 | 2004-02-16 | Asahi Kasei Kabushiki Kaisha | Stem cells for treating pancreatic damage |
| BR0305721A (pt) * | 2002-07-31 | 2004-09-28 | Saint Laurent Parfums | Célula-tronco humana, população de células, processo para obtenção de células-tronco, para a produção de células diferenciadas da linhagem mesodérmica, para seleção que permite identificar agentes suscetìveis de apresentar uma atividade lipolìtica e uma atividade insulino-sensibilizante, utilização de uma célula, utilização de células-tronco, composição farmacêutica, célula humana, população celular humana multipotente |
| US9969977B2 (en) * | 2002-09-20 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| US7074561B2 (en) * | 2002-10-22 | 2006-07-11 | Biomerieux, Inc. | Isothermal amplification based assay for the detection and quantitation of alpha-fetoprotein mRNA |
| WO2004087896A2 (fr) * | 2003-03-31 | 2004-10-14 | Pfizer Products Inc. | Mise en croissance et differenciation de cellules souches |
| DE10362002B4 (de) | 2003-06-23 | 2006-10-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Adulte pluripotente Stammzellen |
| CA2530490A1 (fr) * | 2003-06-25 | 2005-01-13 | Stephen F. Badylak | Compositions matricielles conditionnees pour la restauration d'un tissu |
| US7875272B2 (en) | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| ES2569780T3 (es) | 2003-06-27 | 2016-05-12 | DePuy Synthes Products, Inc. | Células posparto derivadas de tejido placentario y métodos de preparación y uso de las mismas |
| US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
| US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
| US8192348B2 (en) * | 2003-07-01 | 2012-06-05 | Regents Of The University Of Minnesota | Engineered blood vessels |
| AU2004280616A1 (en) * | 2003-10-08 | 2005-04-21 | Vet-Stem Inc. | Methods of preparing and using stem cell compositions and kits comprising the same |
| GB0329449D0 (en) * | 2003-12-19 | 2004-01-28 | Omnicyte Ltd | Stem cells |
| WO2005095588A1 (fr) * | 2004-03-31 | 2005-10-13 | Kyoto University | Écorce glutamatergique précurseur de neurone produisant une écorce glutamatergique précurseuse de neurone seule in vivo. |
| EP1737947B9 (fr) * | 2004-04-21 | 2012-04-25 | Regents Of The University Of Minnesota | Generation de tissu pulmonaire des cellules mapc |
| US7622108B2 (en) * | 2004-04-23 | 2009-11-24 | Bioe, Inc. | Multi-lineage progenitor cells |
| US7670596B2 (en) * | 2004-04-23 | 2010-03-02 | Bioe, Inc. | Multi-lineage progenitor cells |
| WO2005112959A2 (fr) | 2004-05-17 | 2005-12-01 | Regents Of The University Of Minnesota | Utilisation de cellules souches de cordon ombilical pour traiter un evenement ischemique |
| US20080064034A1 (en) * | 2004-05-21 | 2008-03-13 | Fraunhofer-Gesellschaft Zur Förderung Der Angewand | Multi-Cellular Test Systems |
| EP1789540B9 (fr) * | 2004-09-03 | 2012-02-22 | Moraga Biotechnology Inc. | Cellules souches de type blastomeres totipotentes non embryonnaires et procedes associes |
| CN101103101B (zh) * | 2004-09-24 | 2012-10-10 | 成血管细胞系统公司 | 增强间充质前体细胞(mpc)的增生和/或存活的方法 |
| EP1797171A1 (fr) * | 2004-09-29 | 2007-06-20 | Cellartis AB | Generation de cellules hepatocytaires a partir de souches derivant de blastocytes humains (hbs) |
| US20090130064A1 (en) * | 2004-10-27 | 2009-05-21 | Vera Rogiers | Differentiation of stem cells and stabilization of phenotypical properties of primary cells |
| JP2008029201A (ja) * | 2004-11-05 | 2008-02-14 | Hidechika Okada | 幹細胞の調整方法と組織治療剤。 |
| US7883535B2 (en) | 2004-11-09 | 2011-02-08 | Institut National D'optique | Device and method for transmitting multiple optically-encoded stimulation signals to multiple cell locations |
| CA2589063C (fr) | 2004-12-23 | 2016-08-09 | DePuy Synthes Products, Inc. | Traitement de la maladie de parkinson et de troubles associes au moyen de cellules derivees postnatales |
| EP1859028B1 (fr) | 2005-02-10 | 2015-12-02 | Regents Of The University Of Minnesota | Cellules endothéliales vasculaires |
| JP2009509911A (ja) * | 2005-05-05 | 2009-03-12 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | リンパ造血組織を定着させるためのmapcまたはそれらの子孫の使用 |
| WO2006121454A2 (fr) * | 2005-05-05 | 2006-11-16 | Regents Of The University Of Minnesota | Utilisation de mapc ou de sa descendance pour peupler des tissus lympho-hematopoietiques |
| AU2005331559B2 (en) * | 2005-05-05 | 2012-04-19 | Regents Of The University Of Minnesota | Use of NK cell inhibition to facilitate persistence of engrafted MHC-I negative cells |
| EP2465924A3 (fr) * | 2005-06-16 | 2013-01-02 | Ramot at Tel-Aviv University Ltd. | Cellules isolées et populations les comportant pour le traitement des maladies du SNC |
| US20080194024A1 (en) * | 2005-07-29 | 2008-08-14 | Mays Robert W | Culture of Non-Embryonic Cells at High Cell Density |
| WO2007025166A2 (fr) | 2005-08-25 | 2007-03-01 | Repair Technologies, Inc. | Dispositifs, compositions et methodes de protection et de reparation de cellules et de tissus |
| EP1957633B1 (fr) | 2005-10-13 | 2013-12-18 | Anthrogenesis Corporation | Immunomodulation realisee avec des cellules souches placentaires |
| US10117900B2 (en) * | 2005-11-09 | 2018-11-06 | Athersys, Inc. | MAPC treatment of brain injuries and diseases |
| US11000546B2 (en) * | 2005-11-09 | 2021-05-11 | Athersys, Inc. | Immunomodulatory properties of MAPCs and uses thereof |
| KR100697326B1 (ko) * | 2005-12-02 | 2007-03-20 | 재단법인서울대학교산학협력재단 | Oct4 발현능을 가지는 제대혈 유래 다분화능 성체줄기세포 및 그의 제조방법 |
| US9175261B2 (en) | 2005-12-16 | 2015-11-03 | DePuy Synthes Products, Inc. | Human umbilical cord tissue cells for inhibiting adverse immune response in histocompatibility-mismatched transplantation |
| US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
| KR20180105266A (ko) | 2005-12-29 | 2018-09-27 | 안트로제네시스 코포레이션 | 태반 줄기 세포 집단 |
| AU2006332679A1 (en) | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
| EP1981515B1 (fr) | 2006-01-23 | 2013-04-24 | Athersys, Inc. | Traitement à base de mapc de lésions et de maladies cérébrales |
| CA3028321C (fr) * | 2006-01-23 | 2022-06-21 | Athersys, Inc. | Traitement a base de mapc de lesions et de maladies cerebrales |
| GEP20135796B (en) | 2006-03-07 | 2013-04-10 | Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation | |
| US20070269411A1 (en) * | 2006-03-10 | 2007-11-22 | Wei Sun | Porous silicon materials and devices |
| KR100871984B1 (ko) | 2006-04-12 | 2008-12-05 | 주식회사 알앤엘바이오 | 태반 조직 유래 다능성 줄기세포 및 이를 함유하는세포치료제 |
| CA2646491A1 (fr) * | 2006-04-17 | 2007-10-25 | Bioe, Inc. | Differenciation des cellules progenitrices a lignees multiples et cellules epitheliales respiratoires |
| US7989204B2 (en) | 2006-04-28 | 2011-08-02 | Viacyte, Inc. | Hepatocyte lineage cells |
| KR100792184B1 (ko) * | 2006-05-12 | 2008-01-07 | 재단법인서울대학교산학협력재단 | 개의 제대혈, 태반 및 개 태아의 심장 유래 다분화능 성체줄기세포, 그 제조방법 및 이를 함유하는 세포 치료제 |
| US20080050814A1 (en) * | 2006-06-05 | 2008-02-28 | Cryo-Cell International, Inc. | Procurement, isolation and cryopreservation of fetal placental cells |
| US20080064098A1 (en) * | 2006-06-05 | 2008-03-13 | Cryo-Cell International, Inc. | Procurement, isolation and cryopreservation of maternal placental cells |
| CA2654716A1 (fr) * | 2006-06-09 | 2007-12-21 | Anthrogenesis Corporation | Niche placentaire et son utilisation pour cultiver des cellules souches |
| US7875453B2 (en) * | 2006-06-14 | 2011-01-25 | Bioe Llc | Differentiation of multi-lineage progenitor cells to hepatocytes |
| US7993918B2 (en) * | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
| KR100818213B1 (ko) | 2006-09-22 | 2008-04-01 | 재단법인서울대학교산학협력재단 | 파골세포 기반 적소 유사 구조에 의해 증식능이 증가된인간 제대혈 유래 다분화능 줄기 세포 및 그 제조방법 |
| KR100818214B1 (ko) | 2006-09-29 | 2008-04-01 | 재단법인서울대학교산학협력재단 | 인간 태반조직의 양막 또는 탈락막 유래 다분화능 줄기세포및 그 제조방법 |
| PL2578081T3 (pl) * | 2006-10-11 | 2016-09-30 | Kompozycje, sposoby i urządzenia do leczenia chorób wątroby | |
| NZ606814A (en) | 2006-10-23 | 2014-10-31 | Anthrogenesis Corp | Methods and compositions for treatment of bone defects with placental cell populations |
| JP2010508854A (ja) * | 2006-11-08 | 2010-03-25 | アルダジェン, インコーポレイテッド | 幹細胞移植の後の生着を改善するための方法 |
| WO2008063675A2 (fr) * | 2006-11-24 | 2008-05-29 | Regents Of The University Of Minnesota | Cellules progénitrices endothermiques |
| CN103356710A (zh) | 2007-02-12 | 2013-10-23 | 人类起源公司 | 利用胎盘干细胞治疗炎性疾病 |
| WO2008101100A2 (fr) * | 2007-02-14 | 2008-08-21 | Indiana University Research And Technology Corporation | Composition pour stimuler la formation de structures vasculaires |
| US8574567B2 (en) * | 2007-05-03 | 2013-11-05 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| EP2607477B1 (fr) | 2007-05-03 | 2020-09-23 | The Brigham and Women's Hospital, Inc. | Cellules souches multipotentes et leurs utilisations |
| TWM322542U (en) * | 2007-05-23 | 2007-11-21 | Universal Scient Ind Co Ltd | Testing machine |
| US8354370B2 (en) * | 2007-06-15 | 2013-01-15 | Garnet Biotherapeutics, Inc. | Administering a biological composition or compositions isolated from self-renewing colony forming somatic cell growth medium to treat diseases and disorders |
| CA2688504A1 (fr) | 2007-06-18 | 2008-12-24 | Children's Hospital & Research Center At Oakland | Procede permettant d'isoler du placenta des cellules souches et progenitrices |
| CA2693827A1 (fr) * | 2007-07-25 | 2009-01-29 | Bioe, Inc. | Differenciation de cellules de progeniteur a multiples lignees en chondrocytes |
| EP2203176B1 (fr) | 2007-09-28 | 2014-11-26 | Anthrogenesis Corporation | Elimination des tumeurs au moyen d'un perfusat placentaire humain et de cellules tueuses naturelles intermediaires provenant d'un placenta humain |
| US20110151447A1 (en) * | 2007-11-06 | 2011-06-23 | Children's Medical Center Corporation | Method to produce induced pluripotent stem (ips) cells from non-embryonic human cells |
| SG187493A1 (en) | 2008-01-18 | 2013-02-28 | Univ Minnesota | Stem cell aggregates and methods for making and using |
| US20090233993A1 (en) * | 2008-03-06 | 2009-09-17 | Burnham Institute For Medical Research | Compositions and methods for inhibiting gsk3 activity and uses thereof |
| GB2467982A (en) * | 2008-05-08 | 2010-08-25 | Coretherapix Slu | Pluripotent adult stem cells |
| US20090291494A1 (en) * | 2008-05-21 | 2009-11-26 | Bioe, Inc. | Differentiation of Multi-Lineage Progenitor Cells to Pancreatic Cells |
| ES2729557T3 (es) | 2008-05-28 | 2019-11-04 | Univ Ramot | Células madre mesenquimatosas para el tratamiento de enfermedades del SNC |
| NZ591292A (en) | 2008-08-20 | 2012-10-26 | Anthrogenesis Corp | Improved cell composition and methods of making the same |
| CA2734237C (fr) | 2008-08-20 | 2019-07-02 | Anthrogenesis Corporation | Traitement d'un accident vasculaire cerebral a l'aide de cellules placentaires isolees |
| SI2331109T1 (sl) | 2008-08-22 | 2013-10-30 | Anthrogenesis Corporation | Postopki in sestavki za zdravljenje okvar kosti s populacijami placentarnih celic |
| GB0818725D0 (en) | 2008-10-13 | 2008-11-19 | Habib Nagy A | Pharmaceutical composition |
| WO2010059828A1 (fr) | 2008-11-19 | 2010-05-27 | Anthrogenesis Corporation | Cellules adhérentes issues de l'amnios |
| US10557116B2 (en) | 2008-12-19 | 2020-02-11 | DePuy Synthes Products, Inc. | Treatment of lung and pulmonary diseases and disorders |
| US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
| US8771677B2 (en) | 2008-12-29 | 2014-07-08 | Vladimir B Serikov | Colony-forming unit cell of human chorion and method to obtain and use thereof |
| CA2753679C (fr) * | 2009-02-27 | 2021-03-02 | Cellular Dynamics International, Inc. | Differenciation de cellules pluripotentes |
| KR100950195B1 (ko) * | 2009-03-20 | 2010-03-29 | 서울대학교산학협력단 | Znf281을 발현하는 제대혈 유래 만능 줄기세포의 분리방법 |
| PL2411504T3 (pl) | 2009-03-26 | 2017-10-31 | Depuy Synthes Products Inc | Komórki ludzkiej tkanki pępowinowej jako terapia choroby Alzheimera |
| AU2010235161B2 (en) | 2009-04-09 | 2015-01-22 | Sangamo Therapeutics, Inc. | Targeted integration into stem cells |
| JP2011010653A (ja) * | 2009-06-05 | 2011-01-20 | Kumamoto Univ | 細胞の分化誘導方法 |
| US20110002897A1 (en) * | 2009-06-11 | 2011-01-06 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
| SG176806A1 (en) * | 2009-07-09 | 2012-01-30 | Centocor Ortho Biotech Inc | Cardiac tissue-derived cells |
| SG10201404280XA (en) * | 2009-07-21 | 2014-10-30 | Abt Holding Co | Use of stem cells to reduce leukocyte extravasation |
| AU2010276264B2 (en) | 2009-07-21 | 2013-09-19 | Abt Holding Company | Use of stem cells to reduce leukocyte extravasation |
| WO2011082339A2 (fr) * | 2009-12-31 | 2011-07-07 | Cedars-Sinai Medical Center | Régénération, rétablissement de la fonction et remplacement de la microvascularisation dans des organes et des tissus |
| CA2787992A1 (fr) | 2010-01-26 | 2011-08-04 | Anthrogenesis Corporation | Traitement de cancers associes aux os utilisant des cellules souches placentaires |
| BR112012021451B8 (pt) | 2010-02-25 | 2021-05-25 | Abt Holding Co | uso de células que apresentam uma eficiência desejada para a expressão e/ou secreção dos fatores pró-angiogênicos vegf, cxcl5 e il8, métodos para construir um banco de células, para desenvolver fármaco, e para aumentar a expressão de um ou mais fatores pró-angiogênicos em uma célula realizado in vitro, e, composição |
| DK2539436T3 (da) | 2010-02-25 | 2021-10-18 | Abt Holding Co | Modulering af makrofagaktivering |
| PL2556145T3 (pl) | 2010-04-07 | 2017-02-28 | Anthrogenesis Corporation | Angiogeneza z zastosowaniem łożyskowych komórek macierzystych |
| KR20130092394A (ko) | 2010-04-08 | 2013-08-20 | 안트로제네시스 코포레이션 | 태반 줄기 세포를 사용한 사르코이드증의 치료 |
| DK2568991T6 (en) | 2010-05-12 | 2019-03-18 | Abt Holding Co | MODULATION OF SPLENOCYTES IN CELL THERAPY |
| US9090878B2 (en) | 2010-06-17 | 2015-07-28 | Katholieke Universiteit Leuven | Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the methods, and methods for using the cells |
| RU2445106C1 (ru) * | 2010-07-01 | 2012-03-20 | Закрытое Акционерное Общество "Фарм-Синтез" | Фармацевтическая композиция, предназначенная для лечения заболеваний центральной и периферической нервной системы сосудистого, травматического, токсического, гипоксического и аутоиммунного генеза |
| RU2428196C1 (ru) * | 2010-07-01 | 2011-09-10 | Закрытое Акционерное Общество "Фарм-Синтез" | Способ получения биологически активного комплекса и биологически активный белково-полипептидный комплекс |
| MX342995B (es) | 2010-07-13 | 2016-10-21 | Anthrogenesis Corp | Métodos de generar células asesinas naturales. |
| WO2012027474A1 (fr) | 2010-08-24 | 2012-03-01 | Regents Of The University Of Minnesota | Culture en suspension non statique d'agrégats cellulaires |
| US9725689B2 (en) | 2010-10-08 | 2017-08-08 | Terumo Bct, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
| US8574899B2 (en) | 2010-12-22 | 2013-11-05 | Vladimir B Serikov | Methods for augmentation collection of placental hematopoietic stem cells and uses thereof |
| US8969315B2 (en) | 2010-12-31 | 2015-03-03 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory RNA molecules |
| CN109749996A (zh) * | 2011-01-12 | 2019-05-14 | 城户常雄 | 获得和维持纯化或富集的哺乳动物神经干细胞群和/或神经祖细胞群的培养方法 |
| CA2830375A1 (fr) | 2011-03-30 | 2012-10-04 | Board Of Regents Of The University Of Texas System | Procedes et compositions de ciblage de cellules adipeuses chez des mammiferes |
| DK2714059T3 (en) | 2011-06-01 | 2019-01-21 | Celularity Inc | TREATMENT OF PAIN WHEN USING PLACENT STAM CELLS |
| WO2012168295A1 (fr) | 2011-06-06 | 2012-12-13 | ReGenesys BVBA | Multiplication de cellules souches dans des bioréacteurs à fibres creuses |
| WO2013055476A1 (fr) | 2011-09-09 | 2013-04-18 | Anthrogenesis Corporation | Traitement de la sclérose latérale amyotrophique au moyen de cellules souches placentaires |
| KR101981450B1 (ko) | 2011-12-23 | 2019-08-28 | 디퍼이 신테스 프로덕츠, 인코포레이티드 | 인간 제대 조직-유래된 세포의 검출 |
| WO2013151725A1 (fr) | 2012-04-05 | 2013-10-10 | The Regents Of The University Of California | Cellules de sérums de régénération et cellules souches mésenchymateuses |
| EP3622960A1 (fr) | 2013-02-05 | 2020-03-18 | Celularity, Inc. | Cellules tueuses naturelles placentaires |
| KR102161726B1 (ko) | 2013-04-12 | 2020-10-06 | 사베리오 라프란체스카 | 이식용 장기의 개선 |
| EP2992088B1 (fr) | 2013-04-30 | 2019-08-21 | Katholieke Universiteit Leuven | Traitement cellulaire des syndromes myélodysplasiques |
| EP3068867B1 (fr) | 2013-11-16 | 2018-04-18 | Terumo BCT, Inc. | Expansion de cellules dans un bioréacteur |
| US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
| EP3198006B1 (fr) | 2014-09-26 | 2021-03-24 | Terumo BCT, Inc. | Alimentation programmée |
| US10683484B2 (en) | 2015-06-12 | 2020-06-16 | National University Of Singapore | Derivation of hepatic stem cells and mature liver cell types and uses thereof |
| WO2017004592A1 (fr) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Croissance cellulaire à l'aide de stimuli mécaniques |
| US10842822B2 (en) | 2015-10-05 | 2020-11-24 | Orig3N, Inc. | Diagnosis and treatment of parkinson's disease based on identification and amelioration of liver dysfunction |
| WO2017127123A1 (fr) | 2016-01-21 | 2017-07-27 | Abt Holding Company | Cellules souches pour la cicatrisation de plaie |
| WO2017205667A1 (fr) | 2016-05-25 | 2017-11-30 | Terumo Bct, Inc. | Expansion cellulaire |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| CA3027428A1 (fr) * | 2016-06-14 | 2017-12-21 | Regents Of The University Of Minnesota | Cellules, tissus et organes genetiquement modifies pour le traitement d'une maladie |
| JP7393945B2 (ja) | 2017-03-31 | 2023-12-07 | テルモ ビーシーティー、インコーポレーテッド | 細胞増殖 |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| EP3873503B1 (fr) | 2018-11-04 | 2024-07-24 | Figene, LLC | Traitement de la cachexie à l'aide de cellules fibroblastiques et produits associés |
| CA3119259A1 (fr) * | 2018-11-09 | 2020-05-14 | Figene, Llc | Effets abscopal regeneratifs |
| US20200246390A1 (en) | 2019-02-01 | 2020-08-06 | Abt Holding Company | Multipotent adult projenitor cells for treatment of ich |
| US11697799B2 (en) * | 2019-04-15 | 2023-07-11 | Ossium Health, Inc. | System and method for extraction and cryopreservation of bone marrow |
| US12648968B2 (en) | 2019-09-09 | 2026-06-09 | Spinalcyte Llc | Fibroblast and fibroblast-immunocyte combinations for treatment of subconcussive- and concussive-associated neurological damage |
| KR20230010625A (ko) | 2020-03-11 | 2023-01-19 | 비트 바이오 리미티드 | 간 세포 생성 방법 |
| EP4229183A4 (fr) | 2020-10-14 | 2024-12-11 | Ossium Health, Inc. | Compositions et procédés d'extraction de cellules souches mésenchymateuses |
| EP4314244B1 (fr) | 2021-03-23 | 2025-07-23 | Terumo BCT, Inc. | Capture et multiplication cellulaire |
| US12152699B2 (en) | 2022-02-28 | 2024-11-26 | Terumo Bct, Inc. | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
| WO2024116114A1 (fr) | 2022-11-30 | 2024-06-06 | Universidade Nova De Lisboa | Modèle cellulaire 3d de rétinopathie diabétique précoce |
| EP4379046A1 (fr) | 2022-11-30 | 2024-06-05 | Universidade Nova De Lisboa | Modèle cellulaire 3d de rétinopathie diabétique précoce |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4965204A (en) | 1984-02-06 | 1990-10-23 | The Johns Hopkins University | Human stem cells and monoclonal antibodies |
| US5130144B1 (en) | 1984-02-06 | 1995-08-15 | Univ Johns Hopkins | Human stem cells and monoclonal antibodies |
| US4714680B1 (en) | 1984-02-06 | 1995-06-27 | Univ Johns Hopkins | Human stem cells |
| US5087570A (en) * | 1988-05-10 | 1992-02-11 | Weissman Irving L | Homogeneous mammalian hematopoietic stem cell composition |
| US5635386A (en) | 1989-06-15 | 1997-06-03 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5197985A (en) * | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
| US5733542A (en) * | 1990-11-16 | 1998-03-31 | Haynesworth; Stephen E. | Enhancing bone marrow engraftment using MSCS |
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| AU4543193A (en) | 1992-06-22 | 1994-01-24 | Henry E. Young | Scar inhibitory factor and use thereof |
| US5654183A (en) | 1992-07-27 | 1997-08-05 | California Institute Of Technology | Genetically engineered mammalian neural crest stem cells |
| US5589376A (en) | 1992-07-27 | 1996-12-31 | California Institute Of Technology | Mammalian neural crest stem cells |
| US5928947A (en) | 1992-07-27 | 1999-07-27 | California Institute Of Technology | Mammalian multipotent neural stem cells |
| GB9308271D0 (en) | 1993-04-21 | 1993-06-02 | Univ Edinburgh | Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method |
| CZ307995A3 (en) | 1993-05-24 | 1996-10-16 | Immunex Corp | Ligands for flt3 receptors |
| WO1995003062A1 (fr) * | 1993-07-21 | 1995-02-02 | Cellpro, Incorporated | Procedes et compositions de prevention du rejet immun de greffons organiques pleins |
| WO1995010599A1 (fr) | 1993-10-15 | 1995-04-20 | The University Of Melbourne | Cellules analogues a des cellules souches embryonnaires |
| US5602301A (en) | 1993-11-16 | 1997-02-11 | Indiana University Foundation | Non-human mammal having a graft and methods of delivering protein to myocardial tissue |
| US6015671A (en) | 1995-06-07 | 2000-01-18 | Indiana University Foundation | Myocardial grafts and cellular compositions |
| US5486659A (en) * | 1994-03-08 | 1996-01-23 | Rosenbush; Stuart W. | Stethoscope protection device and method for using same |
| DE4441327C1 (de) | 1994-11-22 | 1995-11-09 | Inst Pflanzengenetik & Kultur | Embryonale Herzmuskelzellen, ihre Herstellung und ihre Verwendung |
| US5648248A (en) | 1994-12-30 | 1997-07-15 | Boehringer Ingelheim International Gmbh | Methods for producing differentiated cells from immature hematopoietic cells |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5736396A (en) * | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| GB9502022D0 (en) | 1995-02-02 | 1995-03-22 | Abuljadayel Ilham M S | A method for preparing lymphohaematopoietic progenitor cells |
| US5906934A (en) | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
| US6653134B2 (en) | 1995-03-28 | 2003-11-25 | Cp Hahnemann University | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
| US6306575B1 (en) | 1995-06-16 | 2001-10-23 | Stemcell Technologies, Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| CA2191655C (fr) | 1995-12-01 | 2010-01-12 | Terry E. Thomas | Nouvelles compositions anticorps pour l'obtention de preparations hematopoietiques humaines enrichies et de preparations de cellules tumorales |
| US20010012513A1 (en) | 1996-08-19 | 2001-08-09 | University Of Massachusetts | Embryonic or stem-like cell lines produced by cross species nuclear transplantation |
| US6787355B1 (en) | 1996-08-26 | 2004-09-07 | Mcgill University | Multipotent neural stem cells from peripheral tissues and uses thereof |
| AU4984697A (en) | 1996-10-11 | 1998-05-11 | The Texas A & M University System | Methods for the generation of primordial germ cells and transgenic animal species |
| US6090622A (en) | 1997-03-31 | 2000-07-18 | The Johns Hopkins School Of Medicine | Human embryonic pluripotent germ cells |
| US5968829A (en) | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
| WO1999015629A1 (fr) | 1997-09-25 | 1999-04-01 | Cytomatrix, Llc | Procedes et dispositifs de culture a long terme de cellules souches hematopoietiques |
| US6093531A (en) | 1997-09-29 | 2000-07-25 | Neurospheres Holdings Ltd. | Generation of hematopoietic cells from multipotent neural stem cells |
| WO1999027076A1 (fr) | 1997-11-25 | 1999-06-03 | Arc Genomic Research | Cellules souches embryonnaires multipotentes et procedes permettant de les obtenir |
| AU759437B2 (en) | 1998-01-12 | 2003-04-17 | Cold Spring Harbor Laboratory | Extension of cellular lifespan, methods and reagents |
| JP2002517982A (ja) | 1998-04-09 | 2002-06-25 | ブレサゲン リミテッド | 細胞の分化/増殖および維持因子ならびにそれらの使用 |
| WO2001051611A1 (fr) | 2000-01-14 | 2001-07-19 | Bresagen Limited | Production de cellules |
| WO1999061588A1 (fr) | 1998-05-22 | 1999-12-02 | Osiris Therapeutics, Inc. | Production de megacaryocytes par co-culture de cellules souches mesenchymateuses humaines au moyen de cellules cd34+ |
| DE19833476B4 (de) | 1998-07-24 | 2005-08-25 | Huss, Ralf, Dr. | Genetisch modifizierte CD34-Negative, adhärent wachsende hämatopoetische Stammzellen und deren Verwendung in der Gentherapie |
| IL141699A0 (en) | 1998-09-01 | 2002-03-10 | Wisconsin Alumni Res Found | Primate embryonic stem cells with compatible histocompatibility genes |
| AU2707100A (en) | 1998-11-30 | 2000-06-19 | Ivf Sciences Colorado, Inc. | System and sequential culture media for in vitro fertilization |
| US6777231B1 (en) | 1999-03-10 | 2004-08-17 | The Regents Of The University Of California | Adipose-derived stem cells and lattices |
| US20050169896A1 (en) | 1999-05-14 | 2005-08-04 | Henry Ford Health System | Bone marrow transplantation for treatment of stroke |
| AUPQ147799A0 (en) | 1999-07-07 | 1999-07-29 | Medvet Science Pty. Ltd. | Mesenchymal precursor cell |
| CA2379683A1 (fr) | 1999-07-20 | 2001-01-25 | University Of Southern California | Identification d'une cellule multipotente pre-mesenchymale pre-hematopoietique progenitrice |
| JP2003528577A (ja) | 1999-07-29 | 2003-09-30 | バラノヴィッツ,スティーブン | 身体組織の分化転換方法 |
| US8147824B2 (en) | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
| US8075881B2 (en) | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
| US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| US8609412B2 (en) * | 1999-08-05 | 2013-12-17 | Regents Of The University Of Minnesota | Mapc generation of lung tissue |
| EP1226233B1 (fr) * | 1999-08-05 | 2011-06-29 | ABT Holding Company | Cellules souches adultes multipotentes et procede d'isolement |
| US7927587B2 (en) | 1999-08-05 | 2011-04-19 | Regents Of The University Of Minnesota | MAPC administration for the treatment of lysosomal storage disorders |
| EP1218487A2 (fr) | 1999-09-23 | 2002-07-03 | Cell Science Therapeutics | Procedes et dispositifs permettant d'obtenir des cellules de lignee non hematopoietique a partir de cellules de progeniteurs hematopoietiques |
| AU7611500A (en) | 1999-09-24 | 2001-04-24 | Abt Holding Company | Pluripotent embryonic-like stem cells, compositions, methods and uses thereof |
| EP1224259A4 (fr) | 1999-09-27 | 2005-04-27 | Univ Florida | Inversion de diabetes dependant de l'insuline par des cellules souches insulaires, des cellules insulaires progenitrices et des structures de type insulaire |
| JP2003512052A (ja) | 1999-10-15 | 2003-04-02 | アドバンスド セル テクノロジー、インコーポレイテッド | 分化前駆細胞及び系統欠失胚性幹細胞の産生方法 |
| US6280718B1 (en) | 1999-11-08 | 2001-08-28 | Wisconsin Alumni Reasearch Foundation | Hematopoietic differentiation of human pluripotent embryonic stem cells |
| US20010046489A1 (en) | 1999-12-06 | 2001-11-29 | Habener Joel E. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| US6602711B1 (en) | 2000-02-21 | 2003-08-05 | Wisconsin Alumni Research Foundation | Method of making embryoid bodies from primate embryonic stem cells |
| EP1261694B1 (fr) | 2000-02-26 | 2008-01-16 | Artecel, Inc. | CELLULES SOUCHES MULTIPOTENTES PRODUITES A PARTIR DE CELLULES Du STROMA ADIPEUX ET leurs UTILISATIONS |
| US7005252B1 (en) | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
| WO2001068815A1 (fr) | 2000-03-14 | 2001-09-20 | Es Cell International Pte Ltd | Cellules embryonnaires et cellules souches neuronales derivees de celles-ci |
| EP1176189A1 (fr) | 2000-07-21 | 2002-01-30 | Fornix Biosciences N.V. | Cellules de type cellules souches |
| WO2002009650A2 (fr) | 2000-07-31 | 2002-02-07 | New York Medical College | Compositions et procedes destines a la reparation et/ou la regeneration d'un myocarde endommage |
| GB0026252D0 (en) | 2000-10-26 | 2000-12-13 | Univ Edinburgh | Pluripotential stem cells |
| US7560280B2 (en) | 2000-11-03 | 2009-07-14 | Kourion Therapeutics Gmbh | Human cord blood derived unrestricted somatic stem cells (USSC) |
| US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| MXPA03005014A (es) | 2000-12-06 | 2004-09-10 | Robert J Hariri | Metodo para recolectar celulas madres de la placenta. |
| AU2002251935B2 (en) | 2001-02-14 | 2007-11-29 | Celularity Inc. | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| CA2438501C (fr) | 2001-02-14 | 2014-09-16 | Leo T. Furcht | Cellules souches adultes totipotentes, sources de ces cellules, procedes d'obtention et de maintien de ces dernieres, procedes de differentiation de ces cellules, procedes d'utilisation correspondants et cellules derivees des cellules susmentionnees |
| US7056738B2 (en) | 2001-03-23 | 2006-06-06 | Tulane University | Early stage multipotential stem cells in colonies of bone marrow stromal cells |
| KR100449141B1 (ko) | 2001-04-19 | 2004-09-21 | (주)라이프코드 | 간엽 간세포를 신경세포로 분화시키는 방법 |
| US20030003090A1 (en) | 2001-05-31 | 2003-01-02 | Prockop Darwin J. | Directed in vitro differentiation of marrow stromal cells into neural cell progenitors |
| US9969980B2 (en) | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| WO2004050859A2 (fr) | 2002-11-27 | 2004-06-17 | Regents Of The University Of Minnesota | Recombinaison homologue dans des cellules souches adultes multipotentes |
| US20040235165A1 (en) | 2003-05-19 | 2004-11-25 | Darwin Prockop | In vitro differentiation of adult stem cells |
| US8192348B2 (en) | 2003-07-01 | 2012-06-05 | Regents Of The University Of Minnesota | Engineered blood vessels |
| US8426200B2 (en) | 2003-07-02 | 2013-04-23 | Regents Of The University Of Minnesota | Neuronal differentiation of stem cells |
| WO2005021738A1 (fr) | 2003-08-29 | 2005-03-10 | Regents Of The University Of Minnesota | Cellules souches renales et methodes d'isolement, de differenciation et d'utilisation des cellules souches |
-
2002
- 2002-02-14 CA CA2438501A patent/CA2438501C/fr not_active Expired - Lifetime
- 2002-02-14 EP EP02718998A patent/EP1367899A4/fr not_active Withdrawn
- 2002-02-14 EP EP04023157.3A patent/EP1491093B1/fr not_active Expired - Lifetime
- 2002-02-14 JP JP2002565063A patent/JP2004529621A/ja not_active Withdrawn
- 2002-02-14 US US10/467,963 patent/US7838289B2/en not_active Expired - Lifetime
- 2002-02-14 WO PCT/US2002/004652 patent/WO2002064748A2/fr not_active Ceased
- 2002-02-14 IL IL15733202A patent/IL157332A0/xx unknown
-
2003
- 2003-08-11 IL IL157332A patent/IL157332A/en active IP Right Grant
- 2003-08-11 IL IL214623A patent/IL214623A/en active IP Right Grant
-
2005
- 2005-03-21 US US11/084,809 patent/US20050283844A1/en not_active Abandoned
-
2011
- 2011-03-07 US US13/042,205 patent/US20110177595A1/en not_active Abandoned
- 2011-08-11 IL IL214623A patent/IL214623A0/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU214445U1 (ru) * | 2022-07-21 | 2022-10-28 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Курская государственная сельскохозяйственная академия имени И.И. Иванова" | Универсальный зевник для животных |
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| US20110177595A1 (en) | 2011-07-21 |
| IL157332A0 (en) | 2004-02-19 |
| EP1491093A3 (fr) | 2005-05-04 |
| IL157332A (en) | 2011-11-30 |
| WO2002064748A8 (fr) | 2003-04-24 |
| US7838289B2 (en) | 2010-11-23 |
| IL214623A (en) | 2012-10-31 |
| EP1491093A2 (fr) | 2004-12-29 |
| JP2004529621A (ja) | 2004-09-30 |
| WO2002064748A2 (fr) | 2002-08-22 |
| US20050283844A1 (en) | 2005-12-22 |
| CA2438501A1 (fr) | 2002-08-22 |
| US20040107453A1 (en) | 2004-06-03 |
| WO2002064748A3 (fr) | 2003-08-21 |
| EP1491093B1 (fr) | 2013-07-31 |
| EP1367899A2 (fr) | 2003-12-10 |
| IL214623A0 (en) | 2011-09-27 |
| EP1367899A4 (fr) | 2004-07-28 |
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