CA2438520C - Derives de phtalazinone-piperidine en tant qu'inhibiteurs de pde4 - Google Patents

Derives de phtalazinone-piperidine en tant qu'inhibiteurs de pde4 Download PDF

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CA2438520C
CA2438520C CA2438520A CA2438520A CA2438520C CA 2438520 C CA2438520 C CA 2438520C CA 2438520 A CA2438520 A CA 2438520A CA 2438520 A CA2438520 A CA 2438520A CA 2438520 C CA2438520 C CA 2438520C
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salts
compound
solvates
hydrates
formula
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CA2438520A1 (fr
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Gerhard Grundler
Beate Schmidt
Geert Jan Sterk
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Takeda GmbH
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Nycomed GmbH
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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Abstract

Composés représentés par la formule (I) dans laquelle les substituants donnés possèdent les significations indiquées dans la description, ces composés étant de nouveaux inhibiteurs efficaces de PDE4.
CA2438520A 2001-02-15 2002-02-14 Derives de phtalazinone-piperidine en tant qu'inhibiteurs de pde4 Expired - Fee Related CA2438520C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01103496 2001-02-15
EP01103496.4 2001-02-15
PCT/EP2002/001547 WO2002064584A1 (fr) 2001-02-15 2002-02-14 Derives de phtalazinone-piperidine en tant qu'inhibiteurs de pde4

Publications (2)

Publication Number Publication Date
CA2438520A1 CA2438520A1 (fr) 2002-08-22
CA2438520C true CA2438520C (fr) 2011-10-04

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ID=8176497

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Application Number Title Priority Date Filing Date
CA2438520A Expired - Fee Related CA2438520C (fr) 2001-02-15 2002-02-14 Derives de phtalazinone-piperidine en tant qu'inhibiteurs de pde4

Country Status (22)

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US (3) US6953853B2 (fr)
EP (1) EP1362044A1 (fr)
JP (1) JP4301812B2 (fr)
KR (1) KR20030074817A (fr)
CN (1) CN1524080A (fr)
AU (1) AU2002234634B2 (fr)
BG (1) BG108124A (fr)
BR (1) BR0207278A (fr)
CA (1) CA2438520C (fr)
CZ (1) CZ20032491A3 (fr)
EA (1) EA200300836A1 (fr)
EE (1) EE05386B1 (fr)
HR (1) HRP20030636B1 (fr)
HU (1) HUP0303193A3 (fr)
IL (1) IL156812A0 (fr)
MX (1) MXPA03007310A (fr)
NO (1) NO325245B1 (fr)
NZ (1) NZ527424A (fr)
PL (1) PL363391A1 (fr)
SK (1) SK11382003A3 (fr)
WO (1) WO2002064584A1 (fr)
ZA (1) ZA200306815B (fr)

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HRP20030636B1 (en) 2001-02-15 2012-05-31 Nycomed Gmbh Phthalayinone-piperidino-derivatives as pde4 inhibitors
MXPA04002562A (es) * 2001-09-19 2004-05-31 Altana Pharma Ag Combinacion de un pde-4 y nsaid.
HRP20050197A2 (en) * 2002-08-10 2006-06-30 Altana Pharma Ag Piperidine-n-oxide-derivatives
WO2004018449A1 (fr) * 2002-08-10 2004-03-04 Altana Pharma Ag Derives de piperidine utilises comme inhibiteurs de la phospodiesterase-4 (pde4)
JP2005538140A (ja) * 2002-08-10 2005-12-15 アルタナ　ファルマ　アクチエンゲゼルシャフト Ｐｄｅ４インヒビターとしてのピペリジン−ピリダゾン及びフタラゾン
CA2494650A1 (fr) * 2002-08-10 2004-03-04 Altana Pharma Ag Derives de pyridazinone utilises comme inhibiteurs de pde4
US20060148804A1 (en) * 2003-01-14 2006-07-06 Jurgen Braunger Pde4 inhibitors for the treatment of neoplasms of lymphoid cells
WO2004098606A1 (fr) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition comprenant un inhibiteur de la pde4 et shuil-1r ii
WO2004098578A2 (fr) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition comprenant un inhibiteur de la pde4 et un antagoniste du tnf?
WO2004098605A1 (fr) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition pharmaceutique comprenant un inhibiteur de pde4 et il-1 trap
WO2004098633A1 (fr) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition comprenant un inhibiteur de la pde-4 et un antagoniste du tnf-alpha
WO2004103407A2 (fr) * 2003-05-22 2004-12-02 Altana Pharma Ag Composition contenant un inhibiteur de pde4 et un inhibiteur de pde5
WO2005023253A1 (fr) * 2003-09-05 2005-03-17 Altana Pharma Ag Utilisation d'inhibiteurs de pde4 pour le traitement du diabete sucre
AU2005210042B2 (en) * 2004-02-04 2011-04-21 Takeda Gmbh 2-(piperidin-4-yl) -4, 5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
US20080227790A1 (en) * 2004-02-04 2008-09-18 Altana Pharma Ag Pyridazinone Derivatives and their Use as Pde4 Inhibitors
WO2005075457A1 (fr) * 2004-02-04 2005-08-18 Altana Pharma Ag Derives de phtalazinone utilises en tant qu'inhibiteurs de pde4
AU2006222060B2 (en) 2005-03-08 2011-09-01 Takeda Gmbh Roflumilast for the treatment of diabetes mellitus
ZA200804550B (en) 2005-11-09 2009-08-26 Combinatorx Inc Methods, compositions, and kits for the treatment of medical conditions
CA2637245A1 (fr) * 2006-01-17 2007-07-26 Signal Pharmaceuticals, Llc Inhibiteurs de tnf.alpha., de pde4 et de b-raf, compositions comprenant ces inhibiteurs et methodes d'utilisation associees
ES2378281T3 (es) * 2006-07-05 2012-04-10 Nycomed Gmbh Combinación de atorvastatina con un inhibidor de fosfodiesterasa 4 para el tratamiento de neumopatías inflamatorias
AR064424A1 (es) * 2006-12-20 2009-04-01 Glaxo Group Ltd Derivados sustituidos de 1-oxo-ftalazinas y 1-oxo-pirido-piridazinas,composiciones farmaceuticas que los contienen y usos para prevenir y/o tratar enfermedades inflamatorias y alergicas del tracto respiratorio.
SI2148876T1 (sl) 2007-05-16 2012-01-31 Nycomed Gmbh Pirazolonski derivati kot PDE4 inhibitorji
AR074318A1 (es) 2008-11-14 2011-01-05 Nycomed Gmbh Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.
EP2721030B1 (fr) * 2011-06-17 2015-12-16 Takeda GmbH Nouveaux dérivés de phthalazinone-pyrrolopyrimidinecarboxamides
EP2804603A1 (fr) 2012-01-10 2014-11-26 President and Fellows of Harvard College Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation
EP3165224A1 (fr) 2015-11-09 2017-05-10 Albert-Ludwigs-Universität Freiburg Utilisation d'inhibiteurs de pde4 pour la prophylaxie et/ou la thérapie de la dyslipoproteinémie et des troubles apparentés
JP6820717B2 (ja) 2016-10-28 2021-01-27 株式会社日立ハイテク プラズマ処理装置
CN113121417A (zh) * 2019-12-30 2021-07-16 苏州盛迪亚生物医药有限公司 一种新型哌啶衍生物及其药物用途
WO2021192210A1 (fr) 2020-03-27 2021-09-30 株式会社日立ハイテク Procédé de production d'un semi-conducteur

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US20050234062A1 (en) 2005-10-20
US7531540B2 (en) 2009-05-12
HUP0303193A2 (hu) 2003-12-29
HRP20030636B1 (en) 2012-05-31
HUP0303193A3 (en) 2007-08-28
EE200300311A (et) 2003-10-15
US20070129373A1 (en) 2007-06-07
HRP20030636A2 (en) 2005-06-30
PL363391A1 (en) 2004-11-15
US7179810B2 (en) 2007-02-20
BG108124A (bg) 2004-08-31
CN1524080A (zh) 2004-08-25
NO325245B1 (no) 2008-03-10
NO20033618L (no) 2003-10-15
EE05386B1 (et) 2011-02-15
WO2002064584A1 (fr) 2002-08-22
EA200300836A1 (ru) 2004-02-26
US20040067946A1 (en) 2004-04-08
CZ20032491A3 (cs) 2004-01-14
JP2004518727A (ja) 2004-06-24
JP4301812B2 (ja) 2009-07-22
SK11382003A3 (sk) 2004-01-08
ZA200306815B (en) 2004-06-17
US6953853B2 (en) 2005-10-11
CA2438520A1 (fr) 2002-08-22
KR20030074817A (ko) 2003-09-19
BR0207278A (pt) 2004-02-10
IL156812A0 (en) 2004-02-08
NZ527424A (en) 2005-02-25
MXPA03007310A (es) 2003-12-04
NO20033618D0 (no) 2003-08-14
EP1362044A1 (fr) 2003-11-19
AU2002234634B2 (en) 2007-07-26

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