CA2444257A1 - Methods and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry - Google Patents
Methods and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry Download PDFInfo
- Publication number
- CA2444257A1 CA2444257A1 CA002444257A CA2444257A CA2444257A1 CA 2444257 A1 CA2444257 A1 CA 2444257A1 CA 002444257 A CA002444257 A CA 002444257A CA 2444257 A CA2444257 A CA 2444257A CA 2444257 A1 CA2444257 A1 CA 2444257A1
- Authority
- CA
- Canada
- Prior art keywords
- electrodes
- ions
- ion
- filter
- flow path
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/165—Electrospray ionisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
- G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Health & Medical Sciences (AREA)
- Plasma & Fusion (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83649501A | 2001-04-17 | 2001-04-17 | |
| US09/836,495 | 2001-04-17 | ||
| US4097402A | 2002-01-07 | 2002-01-07 | |
| US10/040,974 | 2002-01-07 | ||
| US10/123,030 | 2002-04-12 | ||
| US10/123,030 US6690004B2 (en) | 1999-07-21 | 2002-04-12 | Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry |
| PCT/US2002/012210 WO2002083276A1 (en) | 2001-04-17 | 2002-04-17 | Methods and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2444257A1 true CA2444257A1 (en) | 2002-10-24 |
Family
ID=27365820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002444257A Abandoned CA2444257A1 (en) | 2001-04-17 | 2002-04-17 | Methods and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1387724A4 (de) |
| JP (1) | JP4063676B2 (de) |
| CN (1) | CN1585666A (de) |
| AU (1) | AU2002257177B2 (de) |
| CA (1) | CA2444257A1 (de) |
| IL (1) | IL158386A0 (de) |
| WO (1) | WO2002083276A1 (de) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024201029A1 (en) * | 2023-03-31 | 2024-10-03 | The University Of Liverpool | Differential mobility spectrometer and analysis method |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7148477B2 (en) | 1999-07-21 | 2006-12-12 | Sionex Corporation | System for trajectory-based ion species identification |
| US6690004B2 (en) | 1999-07-21 | 2004-02-10 | The Charles Stark Draper Laboratory, Inc. | Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry |
| US7098449B1 (en) | 1999-07-21 | 2006-08-29 | The Charles Stark Draper Laboratory, Inc. | Spectrometer chip assembly |
| US7005632B2 (en) | 2002-04-12 | 2006-02-28 | Sionex Corporation | Method and apparatus for control of mobility-based ion species identification |
| US7057168B2 (en) | 1999-07-21 | 2006-06-06 | Sionex Corporation | Systems for differential ion mobility analysis |
| US6815669B1 (en) | 1999-07-21 | 2004-11-09 | The Charles Stark Draper Laboratory, Inc. | Longitudinal field driven ion mobility filter and detection system |
| US6806463B2 (en) | 1999-07-21 | 2004-10-19 | The Charles Stark Draper Laboratory, Inc. | Micromachined field asymmetric ion mobility filter and detection system |
| US7129482B2 (en) | 1999-07-21 | 2006-10-31 | Sionex Corporation | Explosives detection using differential ion mobility spectrometry |
| US7091481B2 (en) | 2001-08-08 | 2006-08-15 | Sionex Corporation | Method and apparatus for plasma generation |
| US6727496B2 (en) | 2001-08-14 | 2004-04-27 | Sionex Corporation | Pancake spectrometer |
| AU2003201232A1 (en) * | 2002-02-08 | 2003-09-02 | Ionalytics Corporation | Faims with non-destructive detection of selectively transmitted ions |
| US7122794B1 (en) | 2002-02-21 | 2006-10-17 | Sionex Corporation | Systems and methods for ion mobility control |
| AU2003298597A1 (en) | 2002-10-12 | 2004-05-25 | Sionex Corporation | NOx MONITOR USING DIFFERENTIAL MOBILITY SPECTROMETRY |
| JP2007524964A (ja) * | 2003-06-20 | 2007-08-30 | ブリガム・ヤング・ユニバーシティ | イオン移動度分析及びイオントラップ質量分析のための単一装置 |
| CA2539484A1 (en) | 2003-09-17 | 2005-03-31 | Sionex Corporation | Solid-state flow generator and related systems, applications, and methods |
| CA2547389A1 (en) * | 2003-11-25 | 2005-06-09 | Sionex Corporation | Mobility based apparatus and methods using dispersion characteristics, sample fragmentation, and/or pressure control to improve analysis of a sample |
| EP1735613A4 (de) * | 2004-02-02 | 2009-03-11 | Sionex Corp | Kompaktes probenanalysesystem und diesbezügliche verfahren mit kombinierten chromatographie- und mobilitätsspektrometrietechniken |
| US6967326B2 (en) * | 2004-02-27 | 2005-11-22 | Lucent Technologies Inc. | Mass spectrometers on wafer-substrates |
| GB0503010D0 (en) * | 2005-02-14 | 2005-03-16 | Micromass Ltd | Mass spectrometer |
| US8440968B2 (en) | 2005-02-14 | 2013-05-14 | Micromass Uk Limited | Ion-mobility analyser |
| EP1864315B1 (de) * | 2005-04-01 | 2016-03-30 | Micromass UK Limited | Massenspektrometer |
| WO2006127974A1 (en) * | 2005-05-24 | 2006-11-30 | Sionex Corporation | Combined mass and differential mobility spectrometry |
| US7977627B2 (en) * | 2006-01-10 | 2011-07-12 | Smith Detection-Watford Limited | Ion selection apparatus and method |
| JP5362586B2 (ja) * | 2007-02-01 | 2013-12-11 | サイオネックス コーポレイション | 質量分光計のための微分移動度分光計プレフィルタ |
| CN101688848A (zh) * | 2007-02-05 | 2010-03-31 | 卓漂仪谱公司 | 离子迁移谱仪与方法 |
| GB0708391D0 (en) * | 2007-05-01 | 2007-06-06 | Smiths Detection Watford Ltd | Detection and spectrometers |
| US7863562B2 (en) * | 2007-06-22 | 2011-01-04 | Shimadzu Corporation | Method and apparatus for digital differential ion mobility separation |
| CN101082594B (zh) * | 2007-07-06 | 2010-12-15 | 清华大学 | 物质成分测定装置 |
| CN101738417B (zh) * | 2009-12-08 | 2012-09-05 | 清华大学 | 基于冷场电子检测生化物质的芯片及检测方法 |
| US8389930B2 (en) * | 2010-04-30 | 2013-03-05 | Agilent Technologies, Inc. | Input port for mass spectrometers that is adapted for use with ion sources that operate at atmospheric pressure |
| CN102479664A (zh) * | 2010-11-30 | 2012-05-30 | 中国科学院大连化学物理研究所 | 一种平板式离子迁移谱 |
| CN102478545A (zh) * | 2010-11-30 | 2012-05-30 | 中国科学院大连化学物理研究所 | 一种平板式差分式离子迁移谱 |
| EP2786400B1 (de) * | 2011-11-29 | 2017-01-18 | Dh Technologies Development Pte. Ltd. | Verfahren zur massenanalyse unter verwendung von differentialmobilitätsspektrometern |
| CN103163206A (zh) * | 2011-12-19 | 2013-06-19 | 中国科学院大连化学物理研究所 | 一种复合电离源差分式离子迁移谱 |
| JP6346567B2 (ja) * | 2011-12-28 | 2018-06-20 | マイクロマス・ユーケー・リミテッド | 液相試料の急速蒸発イオン化を行うためのシステムおよび方法 |
| CN102636553B (zh) * | 2012-03-23 | 2014-05-28 | 哈尔滨工业大学（威海） | 纸基电喷雾离子迁移谱分析方法 |
| CN102683151B (zh) * | 2012-05-15 | 2015-01-28 | 中国科学院合肥物质科学研究院 | 一种选择控制反应离子的化学电离质谱仪 |
| CN102723254B (zh) * | 2012-06-20 | 2015-07-22 | 清华大学 | 平板型高场非对称波形离子迁移谱仪的聚焦装置及方法 |
| JP5997650B2 (ja) * | 2013-04-15 | 2016-09-28 | 株式会社日立ハイテクノロジーズ | 分析システム |
| FI124792B (fi) | 2013-06-20 | 2015-01-30 | Helsingin Yliopisto | Menetelmä ja laite näytekaasuvirtauksen partikkelien ionisoimiseksi |
| CA2932671A1 (en) * | 2013-12-31 | 2015-07-09 | Dh Technologies Development Pte. Ltd. | Vacuum dms with high efficiency ion guides |
| CN106687808B (zh) * | 2014-07-07 | 2019-08-20 | 纳米技术分析责任有限公司 | 用于分析时变气流的便携式电子系统 |
| JP6350391B2 (ja) * | 2015-05-22 | 2018-07-04 | 株式会社島津製作所 | 放電イオン化検出器 |
| JP6456863B2 (ja) * | 2016-03-04 | 2019-01-23 | 株式会社日立ハイテクノロジーズ | イオン移動度分離部を備える分析装置 |
| JP6926544B2 (ja) * | 2016-08-05 | 2021-08-25 | 株式会社リコー | 洗浄用空気作成装置及び計測システム |
| CN107357835B (zh) * | 2017-06-22 | 2020-11-03 | 电子科技大学 | 一种基于主题模型和遗忘规律的兴趣预测挖掘方法及系统 |
| GB2566326A (en) * | 2017-09-11 | 2019-03-13 | Owlstone Inc | Ion mobility filter |
| CN109884157B (zh) * | 2017-12-06 | 2021-06-15 | 中国科学院大连化学物理研究所 | 一种新型正负离子快速切换的离子探测器 |
| JP7102733B2 (ja) * | 2018-01-04 | 2022-07-20 | 株式会社リコー | イオン検出装置及び電界非対称波形イオン移動度分光分析システム |
| CN108760637B (zh) * | 2018-07-13 | 2023-11-21 | 金华职业技术学院 | 一种研究分子光异构化的装置 |
| CN110596401B (zh) * | 2019-09-11 | 2024-05-14 | 宁波盘福生物科技有限公司 | 用于蛋白质检测的高场不对称波形离子淌度装置及方法 |
| GB202004961D0 (en) | 2020-04-03 | 2020-05-20 | Micromass Ltd | De-clustering guide |
| CN117702086A (zh) * | 2023-11-29 | 2024-03-15 | 北京印刷学院 | 一种电喷雾原子层气相沉积制膜装置 |
| CN117976515B (zh) * | 2023-12-31 | 2025-11-25 | 宁波华仪宁创智能科技有限公司 | 离子化装置和方法 |
| CN119510546A (zh) * | 2024-11-20 | 2025-02-25 | 山东省分析测试中心 | 一种质谱检测芯片制备系统与方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5420424A (en) * | 1994-04-29 | 1995-05-30 | Mine Safety Appliances Company | Ion mobility spectrometer |
| US5838003A (en) * | 1996-09-27 | 1998-11-17 | Hewlett-Packard Company | Ionization chamber and mass spectrometry system containing an asymmetric electrode |
| US6124592A (en) * | 1998-03-18 | 2000-09-26 | Technispan Llc | Ion mobility storage trap and method |
| US6066848A (en) * | 1998-06-09 | 2000-05-23 | Combichem, Inc. | Parallel fluid electrospray mass spectrometer |
| DE69927983T2 (de) * | 1998-08-05 | 2006-08-24 | National Research Council Canada, Ottawa | Verfahren zur trennung und anreicherung von isotopen in der gasphase |
| AU6363400A (en) * | 1999-07-21 | 2001-02-13 | Exatec, Llc. | Method of promoting uniform process conditions in pecvd reactor for batch production of glazing panels |
| US6495823B1 (en) * | 1999-07-21 | 2002-12-17 | The Charles Stark Draper Laboratory, Inc. | Micromachined field asymmetric ion mobility filter and detection system |
| US6815668B2 (en) * | 1999-07-21 | 2004-11-09 | The Charles Stark Draper Laboratory, Inc. | Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry |
| EP1266395A2 (de) * | 2000-03-14 | 2002-12-18 | National Research Council of Canada | Tandem faims / ionenfalle-apparatur und verfahren |
-
2002
- 2002-04-17 AU AU2002257177A patent/AU2002257177B2/en not_active Ceased
- 2002-04-17 WO PCT/US2002/012210 patent/WO2002083276A1/en not_active Ceased
- 2002-04-17 CN CN02812130.9A patent/CN1585666A/zh active Pending
- 2002-04-17 JP JP2002581074A patent/JP4063676B2/ja not_active Expired - Lifetime
- 2002-04-17 CA CA002444257A patent/CA2444257A1/en not_active Abandoned
- 2002-04-17 IL IL15838602A patent/IL158386A0/xx unknown
- 2002-04-17 EP EP02726767A patent/EP1387724A4/de not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024201029A1 (en) * | 2023-03-31 | 2024-10-03 | The University Of Liverpool | Differential mobility spectrometer and analysis method |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1387724A4 (de) | 2006-03-15 |
| JP4063676B2 (ja) | 2008-03-19 |
| IL158386A0 (en) | 2004-05-12 |
| JP2004529467A (ja) | 2004-09-24 |
| AU2002257177B2 (en) | 2004-11-25 |
| WO2002083276A1 (en) | 2002-10-24 |
| EP1387724A1 (de) | 2004-02-11 |
| CN1585666A (zh) | 2005-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |