CN1585666A - 用于电喷雾增强的高电场非对称离子淌度光谱测定仪的方法和装置 - Google Patents

用于电喷雾增强的高电场非对称离子淌度光谱测定仪的方法和装置 Download PDF

Info

Publication number
CN1585666A
CN1585666A CN02812130.9A CN02812130A CN1585666A CN 1585666 A CN1585666 A CN 1585666A CN 02812130 A CN02812130 A CN 02812130A CN 1585666 A CN1585666 A CN 1585666A
Authority
CN
China
Prior art keywords
ion
electrode
filter
electrodes
flow path
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN02812130.9A
Other languages
English (en)
Chinese (zh)
Inventor
拉安安·A·米勒
欧金琼·G·纳泽罗
加里·A·埃斯曼
埃吉尼·克里洛维
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Charles Stark Draper Laboratory Inc
Original Assignee
Charles Stark Draper Laboratory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/123,030 external-priority patent/US6690004B2/en
Application filed by Charles Stark Draper Laboratory Inc filed Critical Charles Stark Draper Laboratory Inc
Publication of CN1585666A publication Critical patent/CN1585666A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CN02812130.9A 2001-04-17 2002-04-17 用于电喷雾增强的高电场非对称离子淌度光谱测定仪的方法和装置 Pending CN1585666A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US83649501A 2001-04-17 2001-04-17
US09/836,495 2001-04-17
US4097402A 2002-01-07 2002-01-07
US10/040,974 2002-01-07
US10/123,030 2002-04-12
US10/123,030 US6690004B2 (en) 1999-07-21 2002-04-12 Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry

Publications (1)

Publication Number Publication Date
CN1585666A true CN1585666A (zh) 2005-02-23

Family

ID=27365820

Family Applications (1)

Application Number Title Priority Date Filing Date
CN02812130.9A Pending CN1585666A (zh) 2001-04-17 2002-04-17 用于电喷雾增强的高电场非对称离子淌度光谱测定仪的方法和装置

Country Status (7)

Country Link
EP (1) EP1387724A4 (de)
JP (1) JP4063676B2 (de)
CN (1) CN1585666A (de)
AU (1) AU2002257177B2 (de)
CA (1) CA2444257A1 (de)
IL (1) IL158386A0 (de)
WO (1) WO2002083276A1 (de)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101082594B (zh) * 2007-07-06 2010-12-15 清华大学 物质成分测定装置
CN102237249A (zh) * 2010-04-30 2011-11-09 安捷伦科技有限公司 适于在大气压下操作的离子源的质谱仪用输入端口
CN102478545A (zh) * 2010-11-30 2012-05-30 中国科学院大连化学物理研究所 一种平板式差分式离子迁移谱
CN102479664A (zh) * 2010-11-30 2012-05-30 中国科学院大连化学物理研究所 一种平板式离子迁移谱
CN102636553A (zh) * 2012-03-23 2012-08-15 哈尔滨工业大学（威海） 纸基电喷雾离子迁移谱分析方法
CN101738417B (zh) * 2009-12-08 2012-09-05 清华大学 基于冷场电子检测生化物质的芯片及检测方法
CN102683151A (zh) * 2012-05-15 2012-09-19 中国科学院合肥物质科学研究院 一种选择控制反应离子的化学电离质谱仪
CN102723254A (zh) * 2012-06-20 2012-10-10 清华大学 平板型高场非对称波形离子迁移谱仪的聚焦装置及方法
CN103163206A (zh) * 2011-12-19 2013-06-19 中国科学院大连化学物理研究所 一种复合电离源差分式离子迁移谱
CN101680857B (zh) * 2007-05-01 2015-06-10 史密斯探测-沃特福特有限公司 包括用于滤波的间隔电极的离子迁移率光谱仪
CN105122051A (zh) * 2013-04-15 2015-12-02 株式会社日立高新技术 分析系统
CN105308715A (zh) * 2013-06-20 2016-02-03 赫尔辛基大学 用于对样品气体流的粒子离子化的方法和装置
CN105874331A (zh) * 2013-12-31 2016-08-17 Dh科技发展私人贸易有限公司 使用高效离子导向器的真空dms
CN106168614A (zh) * 2015-05-22 2016-11-30 株式会社岛津制作所 放电离子化检测器
CN106885838A (zh) * 2007-02-05 2017-06-23 卓漂仪谱公司 离子迁移谱仪与方法
CN107357835A (zh) * 2017-06-22 2017-11-17 电子科技大学 一种基于主题模型和遗忘规律的兴趣预测挖掘方法及系统
CN108603860A (zh) * 2016-03-04 2018-09-28 株式会社日立高新技术 具备离子迁移率分离部的分析装置
CN108760637A (zh) * 2018-07-13 2018-11-06 金华职业技术学院 一种研究分子光异构化的装置
CN109270155A (zh) * 2011-12-28 2019-01-25 英国质谱有限公司 用于液相样品的快速蒸发电离的系统和方法
CN110006985A (zh) * 2018-01-04 2019-07-12 株式会社理光 离子检测装置及其制造方法、faims系统
CN106687808B (zh) * 2014-07-07 2019-08-20 纳米技术分析责任有限公司 用于分析时变气流的便携式电子系统
CN110596401A (zh) * 2019-09-11 2019-12-20 宁波盘福生物科技有限公司 用于蛋白质检测的高场不对称波形离子淌度装置及方法
CN119510546A (zh) * 2024-11-20 2025-02-25 山东省分析测试中心 一种质谱检测芯片制备系统与方法

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7129482B2 (en) 1999-07-21 2006-10-31 Sionex Corporation Explosives detection using differential ion mobility spectrometry
US7057168B2 (en) 1999-07-21 2006-06-06 Sionex Corporation Systems for differential ion mobility analysis
US7005632B2 (en) 2002-04-12 2006-02-28 Sionex Corporation Method and apparatus for control of mobility-based ion species identification
US7098449B1 (en) 1999-07-21 2006-08-29 The Charles Stark Draper Laboratory, Inc. Spectrometer chip assembly
US6806463B2 (en) 1999-07-21 2004-10-19 The Charles Stark Draper Laboratory, Inc. Micromachined field asymmetric ion mobility filter and detection system
US6815669B1 (en) 1999-07-21 2004-11-09 The Charles Stark Draper Laboratory, Inc. Longitudinal field driven ion mobility filter and detection system
US6690004B2 (en) 1999-07-21 2004-02-10 The Charles Stark Draper Laboratory, Inc. Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry
US7148477B2 (en) 1999-07-21 2006-12-12 Sionex Corporation System for trajectory-based ion species identification
US7091481B2 (en) 2001-08-08 2006-08-15 Sionex Corporation Method and apparatus for plasma generation
US6727496B2 (en) 2001-08-14 2004-04-27 Sionex Corporation Pancake spectrometer
AU2003201232A1 (en) * 2002-02-08 2003-09-02 Ionalytics Corporation Faims with non-destructive detection of selectively transmitted ions
US7122794B1 (en) 2002-02-21 2006-10-17 Sionex Corporation Systems and methods for ion mobility control
US7019291B2 (en) 2002-10-12 2006-03-28 Sionex Corporation NOx monitor using differential mobility spectrometry
EP1651949A4 (de) * 2003-06-20 2010-01-20 Univ Brigham Young Einzelvorrichtung zur ionenmobilitäts- und ionenfallen-massenspektrometrie
US7223970B2 (en) 2003-09-17 2007-05-29 Sionex Corporation Solid-state gas flow generator and related systems, applications, and methods
EP1690074A2 (de) 2003-11-25 2006-08-16 Sionex Corporation Auf mobilität beruhende vorrichtung und verfahren unter verwendung von dispersionseigenschaften, probenfragmentierung und/oder druckkontrolle zur verbesserung der analyse einer probe
WO2005074584A2 (en) * 2004-02-02 2005-08-18 Sionex Corporation Compact sample analysis systems and related methods using combined chromatography and mobility spectrometry techniques
US6967326B2 (en) * 2004-02-27 2005-11-22 Lucent Technologies Inc. Mass spectrometers on wafer-substrates
US8440968B2 (en) 2005-02-14 2013-05-14 Micromass Uk Limited Ion-mobility analyser
GB0503010D0 (en) * 2005-02-14 2005-03-16 Micromass Ltd Mass spectrometer
EP1864315B1 (de) * 2005-04-01 2016-03-30 Micromass UK Limited Massenspektrometer
US8581178B2 (en) 2005-05-24 2013-11-12 Dh Technologies Development Pte. Ltd. Combined mass and differential mobility spectrometry and associated methods, systems, and devices
JP5250424B2 (ja) * 2006-01-10 2013-07-31 スミスズ ディテクション−ワトフォード リミテッド イオン選択装置および方法
JP5362586B2 (ja) * 2007-02-01 2013-12-11 サイオネックス コーポレイション 質量分光計のための微分移動度分光計プレフィルタ
US7863562B2 (en) * 2007-06-22 2011-01-04 Shimadzu Corporation Method and apparatus for digital differential ion mobility separation
US8890062B2 (en) 2011-11-29 2014-11-18 Dh Technologies Development Pte. Ltd. Differential mobility spectrometer and methods thereof
JP6926544B2 (ja) * 2016-08-05 2021-08-25 株式会社リコー 洗浄用空気作成装置及び計測システム
GB2566326A (en) * 2017-09-11 2019-03-13 Owlstone Inc Ion mobility filter
CN109884157B (zh) * 2017-12-06 2021-06-15 中国科学院大连化学物理研究所 一种新型正负离子快速切换的离子探测器
GB202004961D0 (en) 2020-04-03 2020-05-20 Micromass Ltd De-clustering guide
GB202304891D0 (en) * 2023-03-31 2023-05-17 Univ Liverpool Apparatus and method
CN117702086A (zh) * 2023-11-29 2024-03-15 北京印刷学院 一种电喷雾原子层气相沉积制膜装置
CN117976515B (zh) * 2023-12-31 2025-11-25 宁波华仪宁创智能科技有限公司 离子化装置和方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420424A (en) * 1994-04-29 1995-05-30 Mine Safety Appliances Company Ion mobility spectrometer
US5838003A (en) * 1996-09-27 1998-11-17 Hewlett-Packard Company Ionization chamber and mass spectrometry system containing an asymmetric electrode
US6124592A (en) * 1998-03-18 2000-09-26 Technispan Llc Ion mobility storage trap and method
US6066848A (en) * 1998-06-09 2000-05-23 Combichem, Inc. Parallel fluid electrospray mass spectrometer
WO2000008456A1 (en) * 1998-08-05 2000-02-17 National Research Council Canada Method for separation and enrichment of isotopes in gaseous phase
US6815668B2 (en) * 1999-07-21 2004-11-09 The Charles Stark Draper Laboratory, Inc. Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry
US6495823B1 (en) * 1999-07-21 2002-12-17 The Charles Stark Draper Laboratory, Inc. Micromachined field asymmetric ion mobility filter and detection system
WO2001008455A1 (en) * 1999-07-21 2001-02-01 Exatec, Llc. Method of promoting uniform process conditions in pecvd reactor for batch production of glazing panels
EP1273029B8 (de) * 2000-03-14 2006-01-11 National Research Council Canada Faims apparatur und verfahren mit lasergestützter ionisationsquelle

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106885838A (zh) * 2007-02-05 2017-06-23 卓漂仪谱公司 离子迁移谱仪与方法
CN101680857B (zh) * 2007-05-01 2015-06-10 史密斯探测-沃特福特有限公司 包括用于滤波的间隔电极的离子迁移率光谱仪
CN101082594B (zh) * 2007-07-06 2010-12-15 清华大学 物质成分测定装置
CN101738417B (zh) * 2009-12-08 2012-09-05 清华大学 基于冷场电子检测生化物质的芯片及检测方法
CN102237249A (zh) * 2010-04-30 2011-11-09 安捷伦科技有限公司 适于在大气压下操作的离子源的质谱仪用输入端口
CN102237249B (zh) * 2010-04-30 2016-08-17 安捷伦科技有限公司 适于在大气压下操作的离子源的质谱仪用输入端口
CN102478545A (zh) * 2010-11-30 2012-05-30 中国科学院大连化学物理研究所 一种平板式差分式离子迁移谱
CN102479664A (zh) * 2010-11-30 2012-05-30 中国科学院大连化学物理研究所 一种平板式离子迁移谱
CN103163206A (zh) * 2011-12-19 2013-06-19 中国科学院大连化学物理研究所 一种复合电离源差分式离子迁移谱
CN109270155A (zh) * 2011-12-28 2019-01-25 英国质谱有限公司 用于液相样品的快速蒸发电离的系统和方法
CN109270155B (zh) * 2011-12-28 2021-09-10 英国质谱有限公司 用于液相样品的快速蒸发电离的系统和方法
CN102636553B (zh) * 2012-03-23 2014-05-28 哈尔滨工业大学（威海） 纸基电喷雾离子迁移谱分析方法
CN102636553A (zh) * 2012-03-23 2012-08-15 哈尔滨工业大学（威海） 纸基电喷雾离子迁移谱分析方法
CN102683151A (zh) * 2012-05-15 2012-09-19 中国科学院合肥物质科学研究院 一种选择控制反应离子的化学电离质谱仪
CN102723254A (zh) * 2012-06-20 2012-10-10 清华大学 平板型高场非对称波形离子迁移谱仪的聚焦装置及方法
CN105122051B (zh) * 2013-04-15 2017-07-04 株式会社日立高新技术 分析系统
CN105122051A (zh) * 2013-04-15 2015-12-02 株式会社日立高新技术 分析系统
CN105308715A (zh) * 2013-06-20 2016-02-03 赫尔辛基大学 用于对样品气体流的粒子离子化的方法和装置
CN105308715B (zh) * 2013-06-20 2018-03-06 赫尔辛基大学 用于对样品气体流的粒子离子化的方法和装置
US9916972B2 (en) 2013-06-20 2018-03-13 University Of Helsinki Method and device for ionizing particles of a sample gas flow
CN105874331A (zh) * 2013-12-31 2016-08-17 Dh科技发展私人贸易有限公司 使用高效离子导向器的真空dms
US10697944B2 (en) 2014-07-07 2020-06-30 Nanotech Analysis S.R.L. Portable electronic system for the analysis of time-variable gaseous flows
CN106687808B (zh) * 2014-07-07 2019-08-20 纳米技术分析责任有限公司 用于分析时变气流的便携式电子系统
CN106168614B (zh) * 2015-05-22 2017-12-19 株式会社岛津制作所 放电离子化检测器
CN106168614A (zh) * 2015-05-22 2016-11-30 株式会社岛津制作所 放电离子化检测器
CN108603860A (zh) * 2016-03-04 2018-09-28 株式会社日立高新技术 具备离子迁移率分离部的分析装置
CN108603860B (zh) * 2016-03-04 2020-12-15 株式会社日立高新技术 具备离子迁移率分离部的分析装置
CN107357835A (zh) * 2017-06-22 2017-11-17 电子科技大学 一种基于主题模型和遗忘规律的兴趣预测挖掘方法及系统
CN107357835B (zh) * 2017-06-22 2020-11-03 电子科技大学 一种基于主题模型和遗忘规律的兴趣预测挖掘方法及系统
CN110006985A (zh) * 2018-01-04 2019-07-12 株式会社理光 离子检测装置及其制造方法、faims系统
CN110006985B (zh) * 2018-01-04 2022-09-20 株式会社理光 离子检测装置及其制造方法、faims系统
CN108760637A (zh) * 2018-07-13 2018-11-06 金华职业技术学院 一种研究分子光异构化的装置
CN108760637B (zh) * 2018-07-13 2023-11-21 金华职业技术学院 一种研究分子光异构化的装置
CN110596401A (zh) * 2019-09-11 2019-12-20 宁波盘福生物科技有限公司 用于蛋白质检测的高场不对称波形离子淌度装置及方法
CN110596401B (zh) * 2019-09-11 2024-05-14 宁波盘福生物科技有限公司 用于蛋白质检测的高场不对称波形离子淌度装置及方法
CN119510546A (zh) * 2024-11-20 2025-02-25 山东省分析测试中心 一种质谱检测芯片制备系统与方法

Also Published As

Publication number Publication date
EP1387724A4 (de) 2006-03-15
CA2444257A1 (en) 2002-10-24
EP1387724A1 (de) 2004-02-11
WO2002083276A1 (en) 2002-10-24
IL158386A0 (en) 2004-05-12
JP4063676B2 (ja) 2008-03-19
AU2002257177B2 (en) 2004-11-25
JP2004529467A (ja) 2004-09-24

Similar Documents

Publication Publication Date Title
CN1585666A (zh) 用于电喷雾增强的高电场非对称离子淌度光谱测定仪的方法和装置
US6690004B2 (en) Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry
US8217344B2 (en) Differential mobility spectrometer pre-filter assembly for a mass spectrometer
JP2004529467A6 (ja) エレクトロスプレーを使用する高電界非対称イオン移動度分光分析方法および装置
AU2002257177A1 (en) Methods and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry
US20110101214A1 (en) Coupling differential mobility based ambient pressure ion prefiltering and ion focusing at low flow rates for a portable mass spectrometer
US8415619B2 (en) Methods and systems for mass spectrometry
CN102449727B (zh) 具有微分离子迁移率谱仪和质谱仪的离子分析装置及使用方法
US6815669B1 (en) Longitudinal field driven ion mobility filter and detection system
CN1225006C (zh) 纵向场驱动场致非对称离子迁移过滤器和检测系统
US20070272852A1 (en) Differential mobility spectrometer analyzer and pre-filter apparatus, methods, and systems
US20040232325A1 (en) Pancake spectrometer
CN101036213A (zh) 离子迁移率谱仪
US20230268170A1 (en) Devices and processes for mass spectrometry utilizing vibrating sharp-edge spray ionization
US11092569B1 (en) Apparatus and methods for detection of molecules
US11796505B2 (en) Ion mobility spectrometer with center rod
WO2000050880A2 (en) Improvements in or relating to microfluidic sample preparation and mass spectrometry
WO2025045339A1 (en) Improvements in and relating to ion spectrometry
WO2025045340A1 (en) Improvements in and relating to ion spectrometry

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication