CA2446254C - Nouvelles compositions synergetiques de vitamines, de mineraux et d'oligoelements pour stimuler l'elimination des depots de lipide intracellulaire - Google Patents

Nouvelles compositions synergetiques de vitamines, de mineraux et d'oligoelements pour stimuler l'elimination des depots de lipide intracellulaire Download PDF

Info

Publication number: CA2446254C
Authority: CA; Canada
Prior art keywords: vitamin; trace; vitamins; minerals; elements
Prior art date: 2002-04-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA2446254A

Other languages

English (en)

Other versions

CA2446254A1 (fr

Inventor

Ravi Shrivastava

M. Hema Belani

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-19

Filing date

2003-10-22

Publication date

2012-01-03

2002-04-19 Priority to FR0204905A priority Critical patent/FR2838645B1/fr

2003-10-17 Priority to AU2003254759A priority patent/AU2003254759B2/en

2003-10-22 Application filed by Individual filed Critical Individual

2003-10-22 Priority to CA2446254A priority patent/CA2446254C/fr

2003-10-24 Priority to JP2003364492A priority patent/JP2005126379A/ja

2005-04-22 Publication of CA2446254A1 publication Critical patent/CA2446254A1/fr

2012-01-03 Application granted granted Critical

2012-01-03 Publication of CA2446254C publication Critical patent/CA2446254C/fr

2023-10-22 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 63
229940088594 vitamin Drugs 0.000 title claims abstract description 56
229930003231 vitamin Natural products 0.000 title claims abstract description 56
235000013343 vitamin Nutrition 0.000 title claims abstract description 56
239000011782 vitamin Substances 0.000 title claims abstract description 56
229910052500 inorganic mineral Inorganic materials 0.000 title claims abstract description 52
235000010755 mineral Nutrition 0.000 title claims abstract description 52
239000011573 trace mineral Substances 0.000 title claims abstract description 51
235000013619 trace mineral Nutrition 0.000 title claims abstract description 51
239000011707 mineral Substances 0.000 title claims abstract description 49
230000003834 intracellular effect Effects 0.000 title claims abstract description 39
150000002632 lipids Chemical class 0.000 title claims abstract description 37
230000002195 synergetic effect Effects 0.000 title claims abstract description 36
230000008030 elimination Effects 0.000 title abstract description 18
238000003379 elimination reaction Methods 0.000 title abstract description 18
235000005911 diet Nutrition 0.000 claims abstract description 13
230000037396 body weight Effects 0.000 claims abstract description 11
230000037213 diet Effects 0.000 claims abstract description 9
230000003387 muscular Effects 0.000 claims abstract description 4
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 48
239000011777 magnesium Substances 0.000 claims description 41
239000010949 copper Substances 0.000 claims description 37
239000011701 zinc Substances 0.000 claims description 37
AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 36
239000011669 selenium Substances 0.000 claims description 34
OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 33
AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 28
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 28
229960002477 riboflavin Drugs 0.000 claims description 28
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 27
229910052749 magnesium Inorganic materials 0.000 claims description 27
235000001055 magnesium Nutrition 0.000 claims description 27
235000019155 vitamin A Nutrition 0.000 claims description 26
239000011719 vitamin A Substances 0.000 claims description 26
235000019165 vitamin E Nutrition 0.000 claims description 25
239000011709 vitamin E Substances 0.000 claims description 25
229910052725 zinc Inorganic materials 0.000 claims description 25
235000016804 zinc Nutrition 0.000 claims description 25
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 24
229930003427 Vitamin E Natural products 0.000 claims description 24
229910052802 copper Inorganic materials 0.000 claims description 24
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 24
229940046009 vitamin E Drugs 0.000 claims description 24
235000019164 vitamin B2 Nutrition 0.000 claims description 23
239000011716 vitamin B2 Substances 0.000 claims description 23
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 22
BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 22
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 22
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 22
229940045997 vitamin a Drugs 0.000 claims description 22
229910052711 selenium Inorganic materials 0.000 claims description 21
229930003471 Vitamin B2 Natural products 0.000 claims description 20
235000019159 vitamin B9 Nutrition 0.000 claims description 19
239000011727 vitamin B9 Substances 0.000 claims description 19
229930003761 Vitamin B9 Natural products 0.000 claims description 17
239000000546 pharmaceutical excipient Substances 0.000 claims description 14
239000004615 ingredient Substances 0.000 claims description 12
235000006796 hypocaloric diet Nutrition 0.000 claims description 6
230000006372 lipid accumulation Effects 0.000 claims description 6
238000011282 treatment Methods 0.000 claims description 6
239000002537 cosmetic Substances 0.000 claims description 5
230000000378 dietary effect Effects 0.000 claims description 5
235000016709 nutrition Nutrition 0.000 claims description 5
230000000968 intestinal effect Effects 0.000 claims description 4
230000001989 choleretic effect Effects 0.000 claims description 3
235000021025 protein-rich diet Nutrition 0.000 claims description 3
208000008589 Obesity Diseases 0.000 claims description 2
235000020824 obesity Nutrition 0.000 claims description 2
230000035924 thermogenesis Effects 0.000 claims description 2
239000008845 cholagoga Substances 0.000 claims 1
229940124571 cholagogue Drugs 0.000 claims 1
230000037356 lipid metabolism Effects 0.000 claims 1
230000004936 stimulating effect Effects 0.000 claims 1
230000000694 effects Effects 0.000 abstract description 16
238000002360 preparation method Methods 0.000 abstract description 15
230000007812 deficiency Effects 0.000 abstract description 6
238000000034 method Methods 0.000 abstract description 5
235000001916 dieting Nutrition 0.000 abstract description 4
230000037228 dieting effect Effects 0.000 abstract description 4
239000007788 liquid Substances 0.000 abstract description 4
239000007787 solid Substances 0.000 abstract description 4
230000000699 topical effect Effects 0.000 abstract description 4
230000001739 rebound effect Effects 0.000 abstract description 3
238000011160 research Methods 0.000 abstract description 3
239000013585 weight reducing agent Substances 0.000 abstract 1
RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 26
229940091258 selenium supplement Drugs 0.000 description 20
241000196324 Embryophyta Species 0.000 description 16
XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 16
239000000284 extract Substances 0.000 description 16
239000002775 capsule Substances 0.000 description 15
LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 13
229960001948 caffeine Drugs 0.000 description 13
VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 13
239000000419 plant extract Substances 0.000 description 13
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 12
239000000047 product Substances 0.000 description 12
239000000843 powder Substances 0.000 description 11
210000004027 cell Anatomy 0.000 description 9
235000015872 dietary supplement Nutrition 0.000 description 9
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 description 8
239000005751 Copper oxide Substances 0.000 description 8
OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 8
OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 8
235000013734 beta-carotene Nutrition 0.000 description 8
239000011648 beta-carotene Substances 0.000 description 8
TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 8
229960002747 betacarotene Drugs 0.000 description 8
229910000431 copper oxide Inorganic materials 0.000 description 8
235000019152 folic acid Nutrition 0.000 description 8
239000011724 folic acid Substances 0.000 description 8
229960000304 folic acid Drugs 0.000 description 8
239000000395 magnesium oxide Substances 0.000 description 8
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 8
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 8
235000019192 riboflavin Nutrition 0.000 description 8
239000002151 riboflavin Substances 0.000 description 8
239000000126 substance Substances 0.000 description 8
238000012360 testing method Methods 0.000 description 8
239000011787 zinc oxide Substances 0.000 description 8
OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 8
BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 7
DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 7
235000015927 pasta Nutrition 0.000 description 7
239000011781 sodium selenite Substances 0.000 description 7
229960001471 sodium selenite Drugs 0.000 description 7
235000015921 sodium selenite Nutrition 0.000 description 7
235000013311 vegetables Nutrition 0.000 description 7
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
230000001413 cellular effect Effects 0.000 description 6
239000011521 glass Substances 0.000 description 6
239000011785 micronutrient Substances 0.000 description 6
235000013369 micronutrients Nutrition 0.000 description 6
NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 6
ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 6
DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 6
150000003722 vitamin derivatives Chemical class 0.000 description 6
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 5
244000019459 Cynara cardunculus Species 0.000 description 5
235000019106 Cynara scolymus Nutrition 0.000 description 5
239000011575 calcium Substances 0.000 description 5
230000002354 daily effect Effects 0.000 description 5
239000001963 growth medium Substances 0.000 description 5
235000014347 soups Nutrition 0.000 description 5
235000019160 vitamin B3 Nutrition 0.000 description 5
239000011708 vitamin B3 Substances 0.000 description 5
230000004580 weight loss Effects 0.000 description 5
YDDUMTOHNYZQPO-UHFFFAOYSA-N 1,3-bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-4,5-dihydroxycyclohexanecarboxylic acid Natural products OC1C(O)CC(C(O)=O)(OC(=O)C=CC=2C=C(O)C(O)=CC=2)CC1OC(=O)C=CC1=CC=C(O)C(O)=C1 YDDUMTOHNYZQPO-UHFFFAOYSA-N 0.000 description 4
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
SITQVDJAXQSXSA-CEZRHVESSA-N Cynarin Natural products O[C@@H]1C[C@@](C[C@H](O)[C@H]1OC(=O)C=Cc2ccc(O)c(O)c2)(OC(=O)C=Cc3cccc(O)c3O)C(=O)O SITQVDJAXQSXSA-CEZRHVESSA-N 0.000 description 4
YDDUMTOHNYZQPO-RVXRWRFUSA-N Cynarine Chemical compound O([C@@H]1C[C@@](C[C@H]([C@@H]1O)O)(OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C(O)=O)C(=O)\C=C\C1=CC=C(O)C(O)=C1 YDDUMTOHNYZQPO-RVXRWRFUSA-N 0.000 description 4
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 4
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
229930003451 Vitamin B1 Natural products 0.000 description 4
229930003537 Vitamin B3 Natural products 0.000 description 4
LXNHXLLTXMVWPM-UHFFFAOYSA-N Vitamin B6 Natural products CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 4
230000035508 accumulation Effects 0.000 description 4
238000009825 accumulation Methods 0.000 description 4
235000016520 artichoke thistle Nutrition 0.000 description 4
229960005069 calcium Drugs 0.000 description 4
229910052791 calcium Inorganic materials 0.000 description 4
229950009125 cynarine Drugs 0.000 description 4
YDDUMTOHNYZQPO-BKUKFAEQSA-N cynarine Natural products O[C@H]1C[C@@](C[C@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)(OC(=O)C=Cc3ccc(O)c(O)c3)C(=O)O YDDUMTOHNYZQPO-BKUKFAEQSA-N 0.000 description 4
229910052742 iron Inorganic materials 0.000 description 4
229960003512 nicotinic acid Drugs 0.000 description 4
235000020733 paullinia cupana extract Nutrition 0.000 description 4
RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 4
229960003495 thiamine Drugs 0.000 description 4
235000010374 vitamin B1 Nutrition 0.000 description 4
239000011691 vitamin B1 Substances 0.000 description 4
235000019158 vitamin B6 Nutrition 0.000 description 4
239000011726 vitamin B6 Substances 0.000 description 4
229940011671 vitamin b6 Drugs 0.000 description 4
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 3
229920001202 Inulin Polymers 0.000 description 3
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
229930003779 Vitamin B12 Natural products 0.000 description 3
244000273928 Zingiber officinale Species 0.000 description 3
UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 3
239000004927 clay Substances 0.000 description 3
FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 3
229940108928 copper Drugs 0.000 description 3
239000007933 dermal patch Substances 0.000 description 3
229940079593 drug Drugs 0.000 description 3
239000003814 drug Substances 0.000 description 3
235000013305 food Nutrition 0.000 description 3
239000000499 gel Substances 0.000 description 3
235000003642 hunger Nutrition 0.000 description 3
238000000338 in vitro Methods 0.000 description 3
JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 3
229940029339 inulin Drugs 0.000 description 3
239000011630 iodine Substances 0.000 description 3
229910052740 iodine Inorganic materials 0.000 description 3
229940091250 magnesium supplement Drugs 0.000 description 3
239000002609 medium Substances 0.000 description 3
230000007102 metabolic function Effects 0.000 description 3
239000002366 mineral element Substances 0.000 description 3
230000000144 pharmacologic effect Effects 0.000 description 3
239000011591 potassium Substances 0.000 description 3
229910052700 potassium Inorganic materials 0.000 description 3
235000018102 proteins Nutrition 0.000 description 3
102000004169 proteins and genes Human genes 0.000 description 3
108090000623 proteins and genes Proteins 0.000 description 3
231100000331 toxic Toxicity 0.000 description 3
230000002588 toxic effect Effects 0.000 description 3
235000019163 vitamin B12 Nutrition 0.000 description 3
239000011715 vitamin B12 Substances 0.000 description 3
235000021468 vitamin B8 Nutrition 0.000 description 3
235000013618 yogurt Nutrition 0.000 description 3
KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
244000099147 Ananas comosus Species 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
240000006432 Carica papaya Species 0.000 description 2
235000009467 Carica papaya Nutrition 0.000 description 2
244000298479 Cichorium intybus Species 0.000 description 2
235000007542 Cichorium intybus Nutrition 0.000 description 2
240000000560 Citrus x paradisi Species 0.000 description 2
241001634499 Cola Species 0.000 description 2
235000016795 Cola Nutrition 0.000 description 2
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
241000283973 Oryctolagus cuniculus Species 0.000 description 2
240000003444 Paullinia cupana Species 0.000 description 2
235000000556 Paullinia cupana Nutrition 0.000 description 2
240000004808 Saccharomyces cerevisiae Species 0.000 description 2
206010040880 Skin irritation Diseases 0.000 description 2
241000209140 Triticum Species 0.000 description 2
235000021307 Triticum Nutrition 0.000 description 2
229930003268 Vitamin C Natural products 0.000 description 2
235000006886 Zingiber officinale Nutrition 0.000 description 2
230000009471 action Effects 0.000 description 2
239000000853 adhesive Substances 0.000 description 2
230000001070 adhesive effect Effects 0.000 description 2
210000001789 adipocyte Anatomy 0.000 description 2
230000033228 biological regulation Effects 0.000 description 2
229960002685 biotin Drugs 0.000 description 2
235000020958 biotin Nutrition 0.000 description 2
239000011616 biotin Substances 0.000 description 2
230000003915 cell function Effects 0.000 description 2
239000000731 choleretic agent Substances 0.000 description 2
239000006071 cream Substances 0.000 description 2
231100000433 cytotoxic Toxicity 0.000 description 2
230000001472 cytotoxic effect Effects 0.000 description 2
235000012869 dehydrated soup Nutrition 0.000 description 2
235000013399 edible fruits Nutrition 0.000 description 2
230000006870 function Effects 0.000 description 2
235000008397 ginger Nutrition 0.000 description 2
239000008187 granular material Substances 0.000 description 2
229940094952 green tea extract Drugs 0.000 description 2
235000020688 green tea extract Nutrition 0.000 description 2
230000001939 inductive effect Effects 0.000 description 2
VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical compound [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 description 2
230000007794 irritation Effects 0.000 description 2
210000003205 muscle Anatomy 0.000 description 2
239000001103 potassium chloride Substances 0.000 description 2
235000011164 potassium chloride Nutrition 0.000 description 2
235000019171 pyridoxine hydrochloride Nutrition 0.000 description 2
239000011764 pyridoxine hydrochloride Substances 0.000 description 2
229960004172 pyridoxine hydrochloride Drugs 0.000 description 2
230000009467 reduction Effects 0.000 description 2
230000035807 sensation Effects 0.000 description 2
235000019615 sensations Nutrition 0.000 description 2
210000002966 serum Anatomy 0.000 description 2
230000036556 skin irritation Effects 0.000 description 2
231100000475 skin irritation Toxicity 0.000 description 2
239000008247 solid mixture Substances 0.000 description 2
230000003867 tiredness Effects 0.000 description 2
208000016255 tiredness Diseases 0.000 description 2
235000021470 vitamin B5 (pantothenic acid) Nutrition 0.000 description 2
235000019154 vitamin C Nutrition 0.000 description 2
239000011718 vitamin C Substances 0.000 description 2
239000002699 waste material Substances 0.000 description 2
235000007119 Ananas comosus Nutrition 0.000 description 1
241001474374 Blennius Species 0.000 description 1
GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
229920001661 Chitosan Polymers 0.000 description 1
235000005979 Citrus limon Nutrition 0.000 description 1
244000131522 Citrus pyriformis Species 0.000 description 1
235000015438 Cola nitida Nutrition 0.000 description 1
241001634496 Cola nitida Species 0.000 description 1
ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
241000195480 Fucus Species 0.000 description 1
229920000569 Gum karaya Polymers 0.000 description 1
ZMJBYMUCKBYSCP-UHFFFAOYSA-N Hydroxycitric acid Chemical compound OC(=O)C(O)C(O)(C(O)=O)CC(O)=O ZMJBYMUCKBYSCP-UHFFFAOYSA-N 0.000 description 1
208000035150 Hypercholesterolemia Diseases 0.000 description 1
240000007049 Juglans regia Species 0.000 description 1
235000009496 Juglans regia Nutrition 0.000 description 1
241000220225 Malus Species 0.000 description 1
244000237986 Melia azadirachta Species 0.000 description 1
235000013500 Melia azadirachta Nutrition 0.000 description 1
102000014171 Milk Proteins Human genes 0.000 description 1
108010011756 Milk Proteins Proteins 0.000 description 1
241000978725 Mimosa tenuiflora Species 0.000 description 1
231100000140 OECD 401 Acute Oral Toxicity Toxicity 0.000 description 1
KIECCKFSGCJGTM-UHFFFAOYSA-N O[Se](O)=O.[SeH2] Chemical compound O[Se](O)=O.[SeH2] KIECCKFSGCJGTM-UHFFFAOYSA-N 0.000 description 1
206010033307 Overweight Diseases 0.000 description 1
241000700159 Rattus Species 0.000 description 1
241000934878 Sterculia Species 0.000 description 1
240000004584 Tamarindus indica Species 0.000 description 1
235000004298 Tamarindus indica Nutrition 0.000 description 1
244000269722 Thea sinensis Species 0.000 description 1
229930003571 Vitamin B5 Natural products 0.000 description 1
229930003316 Vitamin D Natural products 0.000 description 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
239000013543 active substance Substances 0.000 description 1
231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
230000002730 additional effect Effects 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
UNMLVGNWZDHBRA-UFAVQCRNSA-N alpha-L-Fucp-(1->3)-[alpha-D-Manp-(1->6)-[beta-D-Xylp-(1->2)]-beta-D-Manp-(1->4)-beta-D-GlcpNAc-(1->4)]-D-GlcpNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O[C@H]3[C@H]([C@@H](O)[C@H](O)[C@@H](CO[C@@H]4[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)O3)O[C@H]3[C@@H]([C@@H](O)[C@H](O)CO3)O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O UNMLVGNWZDHBRA-UFAVQCRNSA-N 0.000 description 1
239000003125 aqueous solvent Substances 0.000 description 1
238000013142 basic testing Methods 0.000 description 1
229940125388 beta agonist Drugs 0.000 description 1
238000009835 boiling Methods 0.000 description 1
FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
239000004227 calcium gluconate Substances 0.000 description 1
229960004494 calcium gluconate Drugs 0.000 description 1
235000013927 calcium gluconate Nutrition 0.000 description 1
229960002079 calcium pantothenate Drugs 0.000 description 1
NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 1
244000309466 calf Species 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
230000003197 catalytic effect Effects 0.000 description 1
238000004113 cell culture Methods 0.000 description 1
239000013553 cell monolayer Substances 0.000 description 1
229940059958 centella asiatica extract Drugs 0.000 description 1
235000013339 cereals Nutrition 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000012790 confirmation Methods 0.000 description 1
235000000639 cyanocobalamin Nutrition 0.000 description 1
239000011666 cyanocobalamin Substances 0.000 description 1
RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 1
210000000805 cytoplasm Anatomy 0.000 description 1
230000001086 cytosolic effect Effects 0.000 description 1
231100000135 cytotoxicity Toxicity 0.000 description 1
KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
235000013325 dietary fiber Nutrition 0.000 description 1
235000021004 dietary regimen Nutrition 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000002934 diuretic Substances 0.000 description 1
230000001882 diuretic effect Effects 0.000 description 1
235000006694 eating habits Nutrition 0.000 description 1
230000002500 effect on skin Effects 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
229960002179 ephedrine Drugs 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
230000003203 everyday effect Effects 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
238000009472 formulation Methods 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
235000009569 green tea Nutrition 0.000 description 1
230000036541 health Effects 0.000 description 1
230000003054 hormonal effect Effects 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
230000006872 improvement Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
238000011835 investigation Methods 0.000 description 1
239000002085 irritant Substances 0.000 description 1
231100000021 irritant Toxicity 0.000 description 1
239000000231 karaya gum Substances 0.000 description 1
235000010494 karaya gum Nutrition 0.000 description 1
229940039371 karaya gum Drugs 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
235000021239 milk protein Nutrition 0.000 description 1
235000006180 nutrition needs Nutrition 0.000 description 1
235000003715 nutritional status Nutrition 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
239000001814 pectin Substances 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
230000035515 penetration Effects 0.000 description 1
-1 pharmaceutical Substances 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
230000035479 physiological effects, processes and functions Effects 0.000 description 1
239000003075 phytoestrogen Substances 0.000 description 1
229940013712 pineapple extract Drugs 0.000 description 1
235000013997 pineapple juice Nutrition 0.000 description 1
239000004033 plastic Substances 0.000 description 1
238000000275 quality assurance Methods 0.000 description 1
238000012216 screening Methods 0.000 description 1
230000035946 sexual desire Effects 0.000 description 1
210000003491 skin Anatomy 0.000 description 1
239000002904 solvent Substances 0.000 description 1
235000013599 spices Nutrition 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
210000004003 subcutaneous fat Anatomy 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
229940042585 tocopherol acetate Drugs 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
229940100640 transdermal system Drugs 0.000 description 1
210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
235000009492 vitamin B5 Nutrition 0.000 description 1
239000011675 vitamin B5 Substances 0.000 description 1
235000011912 vitamin B7 Nutrition 0.000 description 1
235000019166 vitamin D Nutrition 0.000 description 1
239000011710 vitamin D Substances 0.000 description 1
150000003710 vitamin D derivatives Chemical class 0.000 description 1
229940046008 vitamin d Drugs 0.000 description 1
235000020234 walnut Nutrition 0.000 description 1
230000036642 wellbeing Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Inorganic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nutrition Science (AREA)
Food Science & Technology (AREA)
Obesity (AREA)
Birds (AREA)
Diabetes (AREA)
Mycology (AREA)
Hematology (AREA)
Polymers & Plastics (AREA)
Pediatric Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Child & Adolescent Psychology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Cosmetics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA2446254A 2002-04-19 2003-10-22 Nouvelles compositions synergetiques de vitamines, de mineraux et d'oligoelements pour stimuler l'elimination des depots de lipide intracellulaire Expired - Fee Related CA2446254C (fr)

Priority Applications (4)

Application Number	Priority Date	Filing Date	Title
FR0204905A FR2838645B1 (fr)	2002-04-19	2002-04-19	Nouvelles compositions synergiques de vitamines, de mineraux et d'oligo-elements pour stimuler l'elimination des lipides intracellulaires
AU2003254759A AU2003254759B2 (en)	2002-04-19	2003-10-17	New synergetic compositions of vitamins, minerals and trace-elements to stimulate the elimination of intra-cellular lipid deposits
CA2446254A CA2446254C (fr)	2002-04-19	2003-10-22	Nouvelles compositions synergetiques de vitamines, de mineraux et d'oligoelements pour stimuler l'elimination des depots de lipide intracellulaire
JP2003364492A JP2005126379A (ja)	2002-04-19	2003-10-24	細胞内脂質沈着の排出を刺激するためのビタミン類、ミネラル類および微量元素の新規な相乗作用性組成物

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
FR0204905A FR2838645B1 (fr)	2002-04-19	2002-04-19	Nouvelles compositions synergiques de vitamines, de mineraux et d'oligo-elements pour stimuler l'elimination des lipides intracellulaires
AU2003254759A AU2003254759B2 (en)	2002-04-19	2003-10-17	New synergetic compositions of vitamins, minerals and trace-elements to stimulate the elimination of intra-cellular lipid deposits
CA2446254A CA2446254C (fr)	2002-04-19	2003-10-22	Nouvelles compositions synergetiques de vitamines, de mineraux et d'oligoelements pour stimuler l'elimination des depots de lipide intracellulaire
JP2003364492A JP2005126379A (ja)	2002-04-19	2003-10-24	細胞内脂質沈着の排出を刺激するためのビタミン類、ミネラル類および微量元素の新規な相乗作用性組成物

Publications (2)

Publication Number	Publication Date
CA2446254A1 CA2446254A1 (fr)	2005-04-22
CA2446254C true CA2446254C (fr)	2012-01-03

Family

ID=34714413

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2446254A Expired - Fee Related CA2446254C (fr)	2002-04-19	2003-10-22	Nouvelles compositions synergetiques de vitamines, de mineraux et d'oligoelements pour stimuler l'elimination des depots de lipide intracellulaire

Country Status (4)

Country	Link
JP (1)	JP2005126379A (fr)
AU (1)	AU2003254759B2 (fr)
CA (1)	CA2446254C (fr)
FR (1)	FR2838645B1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1598063A1 (fr) *	2003-10-22	2005-11-23	Ravi Shrivastava	Compositions synergiques de vitamines, de minéraux et d'oligo-éléments pour stimuler l'élimination des lipides intracellulaires
FR2883472B1 (fr) *	2005-03-23	2010-09-03	Rocher Yves Biolog Vegetale	Utilisation d'un acide chlorogenique en tant qu'un actif amincissant
WO2007089267A1 (fr) *	2006-02-03	2007-08-09	Jr Chem, Llc	Traitement anti-vieillissement utilisant des préparations de cuivre et de zinc
US8491937B2 (en) *	2007-02-15	2013-07-23	Wyeth Llc	Stability in vitamin and mineral supplements
DE112020001186A5 (de) *	2019-03-11	2022-03-17	Gerhard Hermann	Nahrungsergänzungsmittel

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1356370A (en) *	1972-03-06	1974-06-12	Howard A N	Methods and formulations for the treatment of obesity
US4298601A (en) *	1972-03-06	1981-11-03	Technutra, S.A.	Method and formulations for the treatment of obesity
JPS5592645A (en) *	1978-12-29	1980-07-14	Yoshiko Saeki	Food composition
US5340315A (en) *	1991-06-27	1994-08-23	Abbott Laboratories	Method of treating obesity
JPH08259461A (ja) *	1995-03-24	1996-10-08	Snow Brand Milk Prod Co Ltd	脂質代謝改善剤
FR2733418B1 (fr) *	1995-04-28	1997-08-01	Ravi Shrivastava	Nouvelles associations comprenant du (-) hydroxycitrate et presentant notamment de nouvelles activites therapeutiques
FR2747307B1 (fr) *	1996-04-11	1998-07-10	Ravi Shrivastava	Application a titre de medicament des ceramides et compositions notamment pharmaceutiques les renfermant
FR2747308B1 (fr) *	1996-04-11	1998-07-10	Shrivastava Ravi	Association de margousier, de (-) hydroxycitrate et de ceramides et compositions les renfermant
FR2754820B1 (fr) *	1996-10-22	1999-10-22	Ravi Shrivastava	Le (-)hydroxycitrate de magnesium, procede de preparation, applications, et compositions notamment pharmaceutiques le renfermant
FR2801214B1 (fr) *	1999-11-24	2002-09-20	Ravishekhaz Shrivastava	Utilisation en combinaison de nouvelles compositions solides et non solides pour traiter la dilatation abdominale
JP2004515508A (ja) *	2000-12-16	2004-05-27	アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	化合物の健康促進組成物

2002
- 2002-04-19 FR FR0204905A patent/FR2838645B1/fr not_active Expired - Fee Related
2003
- 2003-10-17 AU AU2003254759A patent/AU2003254759B2/en not_active Ceased
- 2003-10-22 CA CA2446254A patent/CA2446254C/fr not_active Expired - Fee Related
- 2003-10-24 JP JP2003364492A patent/JP2005126379A/ja active Pending

Also Published As

Publication number	Publication date
CA2446254A1 (fr)	2005-04-22
FR2838645B1 (fr)	2004-05-28
AU2003254759A1 (en)	2005-05-05
JP2005126379A (ja)	2005-05-19
AU2003254759B2 (en)	2009-09-03
FR2838645A1 (fr)	2003-10-24

Legal Events

Date	Code	Title	Description
2008-06-25	EEER	Examination request
2017-12-04	MKLA	Lapsed	Effective date: 20171023

Publication	Publication Date	Title
Navarra	2014	The encyclopedia of vitamins, minerals, and supplements
US20200113982A1 (en)	2020-04-16	Composition and Uses Thereof
WO2018112475A1 (fr)	2018-06-21	Compositions énergisantes et procédés
CA2446254C (fr)	2012-01-03	Nouvelles compositions synergetiques de vitamines, de mineraux et d'oligoelements pour stimuler l'elimination des depots de lipide intracellulaire
TWI612905B (zh)	2018-02-01	一種用以對抗環境壓力之影響、改善免疫力及改善活力，同時處理維生素與礦物質缺乏症，而沒有高劑量營養補充品之不良副作用的多維生素／礦物質組配物
US20180169071A1 (en)	2018-06-21	Nutritional supplement composition
WO2006021930A2 (fr)	2006-03-02	Composition aux herbes aphrodisiaques pour les femmes, comprimes ou capsules comprenant cette composition et procede d'auto-administration de ladite composition
US20050266096A1 (en)	2005-12-01	New synergetic compositions of vitamins, minerals and trace-elements to stimulate the elimination of intra-cellular lipid deposits
US7371415B1 (en)	2008-05-13	Method and composition for improving sexual fitness
KR101100904B1 (ko)	2012-01-02	세포내 지질 부착물 제거를 자극하는 비타민, 미네랄 및미량원소로 이루어진 새로운 상승작용성 조성물
KR100441308B1 (ko)	2004-07-21	다이어트 인삼복합음료 및 그 제조방법
JP2001321126A (ja)	2001-11-20	食品組成物
CN100488519C (zh)	2009-05-20	一种治疗痛经的药物及其制备方法
HK1085655A (en)	2006-09-01	Synergic compositions comprising vitamins, minerals and trace elements to stimulate removal of intracellular lipids
EP1598063A1 (fr)	2005-11-23	Compositions synergiques de vitamines, de minéraux et d'oligo-éléments pour stimuler l'élimination des lipides intracellulaires
RU2722728C1 (ru)	2020-06-03	Набор для контроля аппетита и нормализации веса тела и способ его применения
FR2849601A1 (fr)	2004-07-09	Nouvelles compositions synergiques de boissons stimulant le metabolisme cellulaire pour ameliorer l'efficacite des extraits de plantes
NZ545751A (en)	2009-06-26	A water drink with supplements to alleviate the effects of ageing
WO2003097077A1 (fr)	2003-11-27	Nouvelles formes de dosage pour substances tirees de varietes d'agrumes
US20240358785A1 (en)	2024-10-31	Dietary and food supplement composition for weight loss and appetite reduction and use thereof
AU2009100176A4 (en)	2009-04-09	Nutritional supplements for coffee
AU2006200036B8 (en)	2014-02-27	Vitamin composition, methods and applications
US20250275998A1 (en)	2025-09-04	Compositions for promoting longevity and methods of using the same
CN101474299B (zh)	2013-08-28	用于降低血糖与血脂和治疗糖尿病的药物组合物
JP2017529314A (ja)	2017-10-05	冷え症等の全身症状改善用経口組成物