CA2451932C - Pyrrolopyrimidines as protein kinase inhibitors - Google Patents

Info

Publication number

CA2451932C

CA2451932C CA002451932A CA2451932A CA2451932C CA 2451932 C CA2451932 C CA 2451932C CA 002451932 A CA002451932 A CA 002451932A CA 2451932 A CA2451932 A CA 2451932A CA 2451932 C CA2451932 C CA 2451932C

Authority

CA

Canada

Prior art keywords

alkyl

ny1y2

compound according

heteroaryl

group

Prior art date

2001-06-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• 150000004944 pyrrolopyrimidines Chemical class 0.000 title description 4
• 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
• 239000003909 protein kinase inhibitor Substances 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 180
• 150000003839 salts Chemical class 0.000 claims abstract description 51
• 239000002253 acid Substances 0.000 claims abstract description 33
• 239000000203 mixture Substances 0.000 claims abstract description 33
• 229940002612 prodrug Drugs 0.000 claims abstract description 16
• 239000000651 prodrug Substances 0.000 claims abstract description 16
• 150000001204 N-oxides Chemical class 0.000 claims abstract description 15
• 239000012453 solvate Substances 0.000 claims abstract description 14
• 125000000217 alkyl group Chemical group 0.000 claims description 74
• -1 cyclic acetal Chemical class 0.000 claims description 61
• 125000001072 heteroaryl group Chemical group 0.000 claims description 41
• 125000003118 aryl group Chemical group 0.000 claims description 38
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 29
• 125000005843 halogen group Chemical group 0.000 claims description 29
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 29
• 229910052739 hydrogen Inorganic materials 0.000 claims description 27
• 239000001257 hydrogen Substances 0.000 claims description 27
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 23
• 125000001041 indolyl group Chemical group 0.000 claims description 23
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 21
• 125000003342 alkenyl group Chemical group 0.000 claims description 20
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 20
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 19
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 18
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 14
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• 125000003710 aryl alkyl group Chemical group 0.000 claims description 13
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• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
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